Ludmil Alexandrov

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-3596-4515 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Los Alamos National Lab, Los Alamos, NMPostdoctoral training08/2017Theoretical Biology and Biophysics
    University of Cambridge, Cambridge, UKPhD09/2014Computational Biology
    University of Cambridge, Cambridge, UKMPhil09/2010Computational Biology
    Neumont University, Salt Lake City, UTBS03/2007Computer Science
    Collapse Awards and Honors
    NIEHS2020Outstanding New Environmental Scientist Award
    David and Lucile Packard Foundation2019Packard Fellowship for Science and Engineering
    V Foundation for Cancer Research2019Abeloff V Scholar
    The International Academy for Medical and Biological Engineering2018Early Career Award
    Genetics Society2018The Balfour Prize Lecture
    Alfred P. Sloan Foundation2018Alfred P. Sloan Research Fellowship in Computational & Evolutionary Molecular Biology
    Los Alamos National Lab2016Postdoctoral Distinguished Performance Award
    EACR and Oxford University Press2016Carcinogenesis Young Investigator Award
    SciLifeLab and Science magazine2015Prize for Young Scientists in Genomics and Proteomics
    Fred Hutchinson Cancer Research Center2015Harold M. Weintraub Award
    Los Alamos National Lab2015  - 2017J. Robert Oppenheimer Distinguished Postdoctoral Fellow
    Forbes Magazine2014Forbes as 30 under 30

    Collapse Overview 
    Collapse Overview
    I am a Professor at UC San Diego, holding joint appointments in the Department of Bioengineering and the Department of Cellular and Molecular Medicine. My scientific pursuits focus on harnessing the vast information contained in large-scale omics datasets to deepen our understanding of the mutagenic and non-mutagenic processes that drive cancer initiation and progression. I aim to leverage this knowledge to identify novel cancer prevention strategies and to engineer innovative approaches for targeted treatment. Additionally, I am passionate about developing next generation of artificial intelligence (AI) approaches to address inequalities in precancer interception, cancer diagnosis, and cancer care.
    Collapse Websites

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Preclinical evaluation of avutometinib and defactinib in high-grade endometrioid endometrial cancer. Cancer Med. 2024 Sep; 13(17):e70210. Hartwich TMP, Mansolf M, Demirkiran C, Greenman M, Bellone S, McNamara B, Nandi SP, Alexandrov LB, Yang-Hartwich Y, Coma S, Pachter J, Santin AD. PMID: 39240189; PMCID: PMC11378359.
      View in: PubMed   Mentions:
    2. CarD-T: Interpreting Carcinomic Lexicon via Transformers. medRxiv. 2024 Aug 14. O'Neill J, Reddy GA, Dhillon N, Tripathi O, Alexandrov L, Katira P. PMID: 39185518; PMCID: PMC11343268.
      View in: PubMed   Mentions:
    3. The genomic landscape of 2,023 colorectal cancers. Nature. 2024 Aug 07. Cornish AJ, Gruber AJ, Kinnersley B, Chubb D, Frangou A, Caravagna G, Noyvert B, Lakatos E, Wood HM, Thorn S, Culliford R, Arnedo-Pac C, Househam J, Cross W, Sud A, Law P, Leathlobhair MN, Hawari A, Woolley C, Sherwood K, Feeley N, Gül G, Fernandez-Tajes J, Zapata L, Alexandrov LB, Murugaesu N, Sosinsky A, Mitchell J, Lopez-Bigas N, Quirke P, Church DN, Tomlinson IPM, Sottoriva A, Graham TA, Wedge DC, Houlston RS. PMID: 39112709.
      View in: PubMed   Mentions:    Fields:    
    4. Enhanced precision in immunotherapy. Nat Cancer. 2024 Aug; 5(8):1136-1138. Bergstrom EN, Alexandrov LB. PMID: 39134713.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Deep Learning Artificial Intelligence Predicts Homologous Recombination Deficiency and Platinum Response From Histologic Slides. J Clin Oncol. 2024 Jul 31; JCO2302641. Bergstrom EN, Abbasi A, Díaz-Gay M, Galland L, Ladoire S, Lippman SM, Alexandrov LB. PMID: 39083703.
      View in: PubMed   Mentions:    Fields:    
    6. Detecting HRD in whole-genome and whole-exome sequenced breast and ovarian cancers. medRxiv. 2024 Jul 14. Abbasi A, Steele CD, Bergstrom EN, Khandekar A, Farswan A, Mckay RR, Pillay N, Alexandrov LB. PMID: 39040162; PMCID: PMC11261949.
      View in: PubMed   Mentions:
    7. Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK. bioRxiv. 2024 Jun 28. Korenjak M, Temiz NA, Keita S, Chavanel B, Renard C, Sirand C, Cahais V, Mayel T, Vevang KR, Jacobs FC, Guo J, Smith WE, Oram MK, Tabaran FA, Ahlat O, Cornax I, O'Sullivan MG, Das S, Nandi SP, Cheng Y, Alexandrov LB, Balbo S, Hecht SS, Senkin S, Virard F, Peterson LA, Zavadil J. PMID: 38979250; PMCID: PMC11230374.
      View in: PubMed   Mentions:
    8. The mutagenic forces shaping the genomic landscape of lung cancer in never smokers. medRxiv. 2024 May 17. Díaz-Gay M, Zhang T, Hoang PH, Khandekar A, Zhao W, Steele CD, Otlu B, Nandi SP, Vangara R, Bergstrom EN, Kazachkova M, Pich O, Swanton C, Hsiung CA, Chang IS, Wong MP, Leung KC, Sang J, McElderry J, Yang L, Nowak MA, Shi J, Rothman N, Wedge DC, Homer R, Yang SR, Lan Q, Zhu B, Chanock SJ, Alexandrov LB, Landi MT. PMID: 38798417; PMCID: PMC11118654.
      View in: PubMed   Mentions:
    9. The evolution of lung adenocarcinoma precursors is associated with chromosomal instability and transition from innate to adaptive immune response/evasion. Res Sq. 2024 May 15. Hu X, Zhu B, Vokes N, Fujimoto J, Rojas Alvarez FR, Heeke S, Moreira AL, Solis LM, Haymaker C, Velcheti V, Sterman DH, Pass HI, Cheng C, Lee JJ, Zhang J, Wei Z, Wu J, Le X, Ostrin E, Toumazis I, Gibbons D, Su D, Fukuoka J, Antonoff MB, Gerber DE, Li C, Kadara H, Wang L, Davis M, Heymach JV, Hannash S, Wistuba I, Dubinett S, Alexandrov L, Lippman S, Spira A, Futreal AP, Reuben A, Zhang J. PMID: 38798564; PMCID: PMC11118701.
      View in: PubMed   Mentions:
    10. Geographic variation of mutagenic exposures in kidney cancer genomes. Nature. 2024 May; 629(8013):910-918. Senkin S, Moody S, Díaz-Gay M, Abedi-Ardekani B, Cattiaux T, Ferreiro-Iglesias A, Wang J, Fitzgerald S, Kazachkova M, Vangara R, Le AP, Bergstrom EN, Khandekar A, Otlu B, Cheema S, Latimer C, Thomas E, Atkins JR, Smith-Byrne K, Cortez Cardoso Penha R, Carreira C, Chopard P, Gaborieau V, Keski-Rahkonen P, Jones D, Teague JW, Ferlicot S, Asgari M, Sangkhathat S, Attawettayanon W, Swiatkowska B, Jarmalaite S, Sabaliauskaite R, Shibata T, Fukagawa A, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Bartlett JMS, Albert M, Phouthavongsy L, Ashton-Prolla P, Botton MR, Silva Neto B, Bezerra SM, Curado MP, Zequi SC, Reis RM, Faria EF, de Menezes NS, Ferrari RS, Banks RE, Vasudev NS, Zaridze D, Mukeriya A, Shangina O, Matveev V, Foretova L, Navratilova M, Holcatova I, Hornakova A, Janout V, Purdue MP, Rothman N, Chanock SJ, Ueland PM, Johansson M, McKay J, Scelo G, Chanudet E, Humphreys L, de Carvalho AC, Perdomo S, Alexandrov LB, Stratton MR, Brennan P. PMID: 38693263; PMCID: PMC11111402.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    11. The Complexity of Tobacco Smoke-Induced Mutagenesis in Head and Neck Cancer. medRxiv. 2024 Apr 17. Torrens L, Moody S, de Carvalho AC, Kazachkova M, Abedi-Ardekani B, Cheema S, Senkin S, Cattiaux T, Cortez Cardoso Penha R, Atkins JR, Gaborieau V, Chopard P, Carreira C, Abbasi A, Bergstrom EN, Vangara R, Wang J, Fitzgerald S, Latimer C, Diaz-Gay M, Jones D, Teague J, Ribeiro Pinto F, Kowalski LP, Polesel J, Giudici F, de Oliveira JC, Lagiou P, Lagiou A, Vilensky M, Mates D, Mates IN, Arantes LM, Reis R, Podesta JRV, von Zeidler SV, Holcatova I, Curado MP, Canova C, Fabianova E, Rodríguez-Urrego PA, Humphreys L, Alexandrov LB, Brennan P, Stratton MR, Perdomo S. PMID: 38699364; PMCID: PMC11065003.
      View in: PubMed   Mentions:
    12. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. Proc Natl Acad Sci U S A. 2024 Apr 23; 121(17):e2321898121. Bellone S, Jeong K, Halle MK, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich TMP, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Quick CM, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov LB, Siegel ER, Choi J, Schlessinger J, Santin AD. PMID: 38625939; PMCID: PMC11046577.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. APOBEC shapes tumor evolution and age at onset of lung cancer in smokers. bioRxiv. 2024 Apr 03. Zhang T, Sang J, Hoang PH, Zhao W, Rosenbaum J, Johnson KE, Klimczak LJ, McElderry J, Klein A, Wirth C, Bergstrom EN, Díaz-Gay M, Vangara R, Colon-Matos F, Hutchinson A, Lawrence SM, Cole N, Zhu B, Przytycka TM, Shi J, Caporaso NE, Homer R, Pesatori AC, Consonni D, Imielinski M, Chanock SJ, Wedge DC, Gordenin DA, Alexandrov LB, Harris RS, Landi MT. PMID: 38617360; PMCID: PMC11014539.
      View in: PubMed   Mentions:
    14. The Mutographs biorepository: A unique genomic resource to study cancer around the world. Cell Genom. 2024 Mar 13; 4(3):100500. Perdomo S, Abedi-Ardekani B, de Carvalho AC, Ferreiro-Iglesias A, Gaborieau V, Cattiaux T, Renard H, Chopard P, Carreira C, Spanu A, Nikmanesh A, Cardoso Penha RC, Antwi SO, Ashton-Prolla P, Canova C, Chitapanarux T, Cox R, Curado MP, de Oliveira JC, Dzamalala C, Fabianova E, Ferri L, Fitzgerald R, Foretova L, Gallinger S, Goldstein AM, Holcatova I, Huertas A, Janout V, Jarmalaite S, Kaneva R, Kowalski LP, Kulis T, Lagiou P, Lissowska J, Malekzadeh R, Mates D, McCorrmack V, Menya D, Mhatre S, Mmbaga BT, de Moricz A, Nyirády P, Ognjanovic M, Papadopoulou K, Polesel J, Purdue MP, Rascu S, Rebolho Batista LM, Reis RM, Ribeiro Pinto LF, Rodríguez-Urrego PA, Sangkhathat S, Sangrajrang S, Shibata T, Stakhovsky E, Swiatkowska B, Vaccaro C, Vasconcelos de Podesta JR, Vasudev NS, Vilensky M, Yeung J, Zaridze D, Zendehdel K, Scelo G, Chanudet E, Wang J, Fitzgerald S, Latimer C, Moody S, Humphreys L, Alexandrov LB, Stratton MR, Brennan P. PMID: 38325367; PMCID: PMC10943582.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Evaluating topography of mutational signatures with SigProfilerTopography. bioRxiv. 2024 Jan 09. Otlu B, Alexandrov LB. PMID: 38260507; PMCID: PMC10802511.
      View in: PubMed   Mentions:
    16. Nivolumab for Patients With High-Risk Oral Leukoplakia: A Nonrandomized Controlled Trial. JAMA Oncol. 2024 Jan 01; 10(1):32-41. Hanna GJ, Villa A, Nandi SP, Shi R, ONeill A, Liu M, Quinn CT, Treister NS, Sroussi HY, Vacharotayangul P, Goguen LA, Annino DJ, Rettig EM, Jo VY, Wong KS, Lizotte P, Paweletz CP, Uppaluri R, Haddad RI, Cohen EEW, Alexandrov LB, William WN, Lippman SM, Woo SB. PMID: 37971722; PMCID: PMC10654930.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Arsenic is a potent co-mutagen of ultraviolet light. Commun Biol. 2023 12 16; 6(1):1273. Speer RM, Nandi SP, Cooper KL, Zhou X, Yu H, Guo Y, Hudson LG, Alexandrov LB, Liu KJ. PMID: 38104187; PMCID: PMC10725444.
      View in: PubMed   Mentions: 2  Translation:HumansAnimals
    18. Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change. bioRxiv. 2023 Dec 13. Dehkordi SR, Wong IT, Ni J, Luebeck J, Zhu K, Prasad G, Krockenberger L, Xu G, Chowdhury B, Rajkumar U, Caplin A, Muliaditan D, Coruh C, Jin Q, Turner K, Teo SX, Pang AWC, Alexandrov LB, Chua CEL, Furnari FB, Paulson TG, Law JA, Chang HY, Yue F, DasGupta R, Zhao J, Mischel PS, Bafna V. PMID: 38168210; PMCID: PMC10760206.
      View in: PubMed   Mentions:
    19. Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment. Bioinformatics. 2023 12 01; 39(12). Díaz-Gay M, Vangara R, Barnes M, Wang X, Islam SMA, Vermes I, Duke S, Narasimman NB, Yang T, Jiang Z, Moody S, Senkin S, Brennan P, Stratton MR, Alexandrov LB. PMID: 38096571; PMCID: PMC10746860.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    20. Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms. Toxicol Appl Pharmacol. 2024 01; 482:116773. Speer RM, Yu H, Zhou X, Nandi S, Alexandrov L, Guo Y, Hudson LG, Liu KJ. PMID: 38036231; PMCID: PMC10883297.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer. Nat Genet. 2023 10; 55(10):1721-1734. McCann JL, Cristini A, Law EK, Lee SY, Tellier M, Carpenter MA, Beghè C, Kim JJ, Sanchez A, Jarvis MC, Stefanovska B, Temiz NA, Bergstrom EN, Salamango DJ, Brown MR, Murphy S, Alexandrov LB, Miller KM, Gromak N, Harris RS. PMID: 37735199; PMCID: PMC10562255.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator. BMC Genomics. 2023 Aug 21; 24(1):469. Khandekar A, Vangara R, Barnes M, Díaz-Gay M, Abbasi A, Bergstrom EN, Steele CD, Pillay N, Alexandrov LB. PMID: 37605126; PMCID: PMC10440861.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Topography of mutational signatures in human cancer. Cell Rep. 2023 08 29; 42(8):112930. Otlu B, Díaz-Gay M, Vermes I, Bergstrom EN, Zhivagui M, Barnes M, Alexandrov LB. PMID: 37540596; PMCID: PMC10507738.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment. bioRxiv. 2023 Jul 11. Díaz-Gay M, Vangara R, Barnes M, Wang X, Islam SMA, Vermes I, Narasimman NB, Yang T, Jiang Z, Moody S, Senkin S, Brennan P, Stratton MR, Alexandrov LB. PMID: 37502962; PMCID: PMC10369904.
      View in: PubMed   Mentions:
    25. Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023 Jun; 618(7967):1049-1056. Trivedi P, Steele CD, Au FKC, Alexandrov LB, Cleveland DW. PMID: 37316668; PMCID: PMC10424572.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response. Nat Commun. 2023 05 12; 14(1):2744. Pagadala M, Sears TJ, Wu VH, Pérez-Guijarro E, Kim H, Castro A, Talwar JV, Gonzalez-Colin C, Cao S, Schmiedel BJ, Goudarzi S, Kirani D, Au J, Zhang T, Landi T, Salem RM, Morris GP, Harismendy O, Patel SP, Alexandrov LB, Mesirov JP, Zanetti M, Day CP, Fan CC, Thompson WK, Merlino G, Gutkind JS, Vijayanand P, Carter H. PMID: 37173324; PMCID: PMC10182072.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    27. Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. Nature. 2023 04; 616(7958):798-805. Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn AC, Kim H, Jammula S, He Y, Lippman SM, Verhaak RGW, Maley CC, Alexandrov LB, Reid BJ, Fitzgerald RC, Paulson TG, Chang HY, Wu S, Bafna V, Mischel PS. PMID: 37046089; PMCID: PMC10132967.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    28. Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats. Nature. 2023 04; 616(7957):504-509. Li JSZ, Abbasi A, Kim DH, Lippman SM, Alexandrov LB, Cleveland DW. PMID: 37046091; PMCID: PMC10328181.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity. Nat Genet. 2023 04; 55(4):607-618. Mangiante L, Alcala N, Sexton-Oates A, Di Genova A, Gonzalez-Perez A, Khandekar A, Bergstrom EN, Kim J, Liu X, Blazquez-Encinas R, Giacobi C, Le Stang N, Boyault S, Cuenin C, Tabone-Eglinger S, Damiola F, Voegele C, Ardin M, Michallet MC, Soudade L, Delhomme TM, Poret A, Brevet M, Copin MC, Giusiano-Courcambeck S, Damotte D, Girard C, Hofman V, Hofman P, Mouroux J, Cohen C, Lacomme S, Mazieres J, de Montpreville VT, Perrin C, Planchard G, Rousseau N, Rouquette I, Sagan C, Scherpereel A, Thivolet F, Vignaud JM, Jean D, Ilg AGS, Olaso R, Meyer V, Boland-Auge A, Deleuze JF, Altmuller J, Nuernberg P, Ibáñez-Costa A, Castaño JP, Lantuejoul S, Ghantous A, Maussion C, Courtiol P, Hernandez-Vargas H, Caux C, Girard N, Lopez-Bigas N, Alexandrov LB, Galateau-Salle F, Foll M, Fernandez-Cuesta L. PMID: 36928603; PMCID: PMC10101853.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Author Correction: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer. Nat Commun. 2023 Mar 14; 14(1):1424. Zhivagui M, Hoda A, Valenzuela N, Yeh YY, Dai J, He Y, Nandi SP, Otlu B, Van Houten B, Alexandrov LB. PMID: 36918603; PMCID: PMC10014946.
      View in: PubMed   Mentions:    Fields:    
    31. Arsenic is a potent co-mutagen of ultraviolet light. bioRxiv. 2023 Feb 23. Speer RM, Nandi SP, Cooper KL, Zhou X, Yu H, Guo Y, Hudson LG, Alexandrov LB, Liu KJ. PMID: 36865271; PMCID: PMC9980120.
      View in: PubMed   Mentions:
    32. Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator. bioRxiv. 2023 Feb 04. Khandekar A, Vangara R, Barnes M, Díaz-Gay M, Abbasi A, Bergstrom EN, Steele CD, Pillay N, Alexandrov LB. PMID: 36778452; PMCID: PMC9915726.
      View in: PubMed   Mentions:
    33. Author Correction: The repertoire of mutational signatures in human cancer. Nature. 2023 Feb; 614(7948):E41. Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium. PMID: 36697836; PMCID: PMC9931578.
      View in: PubMed   Mentions: 2     Fields:    
    34. Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers. Nat Cancer. 2023 02; 4(2):276-289. Thatikonda V, Islam SMA, Autry RJ, Jones BC, Gröbner SN, Warsow G, Hutter B, Huebschmann D, Fröhling S, Kool M, Blattner-Johnson M, Jones DTW, Alexandrov LB, Pfister SM, Jäger N. PMID: 36702933; PMCID: PMC9970869.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    35. Unraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis syndrome. Front Mol Biosci. 2023; 10:1119900. Bonjoch L, Soares de Lima Y, Díaz-Gay M, Dotti I, Muñoz J, Moreira L, Carballal S, Ocaña T, Cuatrecasas M, Ortiz O, Castells A, Pellisé M, Balaguer F, Salas A, Alexandrov LB, Castellví-Bel S. PMID: 36756361; PMCID: PMC9900627.
      View in: PubMed   Mentions: 2  
    36. DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer. Nat Commun. 2023 01 17; 14(1):276. Zhivagui M, Hoda A, Valenzuela N, Yeh YY, Dai J, He Y, Nandi SP, Otlu B, Van Houten B, Alexandrov LB. PMID: 36650165; PMCID: PMC9845303.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    37. Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis. Nat Commun. 2023 01 05; 14(1):77. Light N, Layeghifard M, Attery A, Subasri V, Zatzman M, Anderson ND, Hatkar R, Blay S, Chen D, Novokmet A, Fuligni F, Tran J, de Borja R, Agarwal H, Waldman L, Abegglen LM, Albertson D, Finlay JL, Hansford JR, Behjati S, Villani A, Gerstung M, Alexandrov LB, Somers GR, Schiffman JD, Rotter V, Malkin D, Shlien A. PMID: 36604421; PMCID: PMC9816166.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    38. Control-independent mosaic single nucleotide variant detection with DeepMosaic. Nat Biotechnol. 2023 06; 41(6):870-877. Yang X, Xu X, Breuss MW, Antaki D, Ball LL, Chung C, Shen J, Li C, George RD, Wang Y, Bae T, Cheng Y, Abyzov A, Wei L, Alexandrov LB, Sebat JL, NIMH Brain Somatic Mosaicism Network, Gleeson JG. PMID: 36593400; PMCID: PMC10314968.
      View in: PubMed   Mentions: 11     Fields:    
    39. Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor. Gynecol Oncol. 2023 02; 169:98-105. Manavella DD, McNamara B, Harold J, Bellone S, Hartwich TMP, Yang-Hartwich Y, Mutlu L, Zipponi M, Demirkiran C, Verzosa MS, Altwerger G, Ratner E, Huang GS, Clark M, Andikyan V, Azodi M, Schwartz PE, Dottino PR, Choi J, Alexandrov LB, Buza N, Hui P, Santin AD. PMID: 36525930; PMCID: PMC9925406.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    40. Somatic 9p24.1 alterations in HPV- head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2213835119. Zhao X, Cohen EEW, William WN, Bianchi JJ, Abraham JP, Magee D, Spetzler DB, Gutkind JS, Alexandrov LB, Cavenee WK, Lippman SM, Davoli T. PMID: 36395141; PMCID: PMC9704728.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    41. Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor. Cell Genom. 2022 Nov 09; 2(11):None. Islam SMA, Díaz-Gay M, Wu Y, Barnes M, Vangara R, Bergstrom EN, He Y, Vella M, Wang J, Teague JW, Clapham P, Moody S, Senkin S, Li YR, Riva L, Zhang T, Gruber AJ, Steele CD, Otlu B, Khandekar A, Abbasi A, Humphreys L, Syulyukina N, Brady SW, Alexandrov BS, Pillay N, Zhang J, Adams DJ, Martincorena I, Wedge DC, Landi MT, Brennan P, Stratton MR, Rozen SG, Alexandrov LB. PMID: 36388765; PMCID: PMC9646490.
      View in: PubMed   Mentions: 88     Fields:    
    42. AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas. JCI Insight. 2022 09 22; 7(18). Ghosh P, Campos VJ, Vo DT, Guccione C, Goheen-Holland V, Tindle C, Mazzini GS, He Y, Alexandrov LB, Lippman SM, Gurski RR, Das S, Yadlapati R, Curtius K, Sahoo D. PMID: 36134663; PMCID: PMC9675486.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. A genetic model for central chondrosarcoma evolution correlates with patient outcome. Genome Med. 2022 08 30; 14(1):99. Cross W, Lyskjær I, Lesluyes T, Hargreaves S, Strobl AC, Davies C, Waise S, Hames-Fathi S, Oukrif D, Ye H, Amary F, Tirabosco R, Gerrand C, Baker T, Barnes D, Steele C, Alexandrov L, Bond G, Genomics England Research Consortium, Cool P, Pillay N, Van Loo P, Flanagan AM. PMID: 36042521; PMCID: PMC9426036.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    44. Mechanisms of APOBEC3 mutagenesis in human cancer cells. Nature. 2022 07; 607(7920):799-807. Petljak M, Dananberg A, Chu K, Bergstrom EN, Striepen J, von Morgen P, Chen Y, Shah H, Sale JE, Alexandrov LB, Stratton MR, Maciejowski J. PMID: 35859169; PMCID: PMC9329121.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    45. Examining clustered somatic mutations with SigProfilerClusters. Bioinformatics. 2022 06 27; 38(13):3470-3473. Bergstrom EN, Kundu M, Tbeileh N, Alexandrov LB. PMID: 35595234; PMCID: PMC9237733.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    46. Signatures of copy number alterations in human cancer. Nature. 2022 06; 606(7916):984-991. Steele CD, Abbasi A, Islam SMA, Bowes AL, Khandekar A, Haase K, Hames-Fathi S, Ajayi D, Verfaillie A, Dhami P, McLatchie A, Lechner M, Light N, Shlien A, Malkin D, Feber A, Proszek P, Lesluyes T, Mertens F, Flanagan AM, Tarabichi M, Van Loo P, Alexandrov LB, Pillay N. PMID: 35705804; PMCID: PMC9242861.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    47. Synergistic activity of neratinib in combination with olaparib in uterine serous carcinoma overexpressing HER2/neu. Gynecol Oncol. 2022 08; 166(2):351-357. Yadav G, Roque DM, Bellone S, Manavella DD, Hartwich TMP, Zipponi M, Harold J, Tymon-Rosario J, Mutlu L, Altwerger G, Menderes G, Ratner E, Buza N, Hui P, Huang GS, Andikyan V, Clark M, Azodi M, Schwartz PE, Alexandrov LB, Santin AD. PMID: 35641325.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    48. An overview of mutational and copy number signatures in human cancer. J Pathol. 2022 07; 257(4):454-465. Steele CD, Pillay N, Alexandrov LB. PMID: 35420163; PMCID: PMC9324981.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    49. Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a poly (adenosine diphosphate [ADP]- ribose) polymerase (PARP) inhibitor. Gynecol Oncol. 2022 07; 166(1):117-125. Tymon-Rosario JR, Manara P, Manavella DD, Bellone S, Hartwich TMP, Harold J, Yang-Hartwich Y, Zipponi M, Choi J, Jeong K, Mutlu L, Yang K, Altwerger G, Menderes G, Ratner E, Huang GS, Clark M, Andikyan V, Azodi M, Schwartz PE, Alexandrov LB, Santin AD. PMID: 35599167.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. Somatic mutational profiles and germline polygenic risk scores in human cancer. Genome Med. 2022 02 11; 14(1):14. Liu Y, Gusev A, Heng YJ, Alexandrov LB, Kraft P. PMID: 35144655; PMCID: PMC8832866.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    51. Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. Nature. 2022 02; 602(7897):510-517. Bergstrom EN, Luebeck J, Petljak M, Khandekar A, Barnes M, Zhang T, Steele CD, Pillay N, Landi MT, Bafna V, Mischel PS, Harris RS, Alexandrov LB. PMID: 35140399; PMCID: PMC8850194.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    52. Unwinding the mutational signatures of a DNA topoisomerase enzyme. Nature. 2022 02; 602(7898):580-581. Abbasi A, Alexandrov LB. PMID: 35140368.
      View in: PubMed   Mentions:    Fields:    
    53. A phase 2 evaluation of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability. Cancer. 2022 03 15; 128(6):1206-1218. Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi DA, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon-Rosario JR, Harold JA, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin JA, Choi J, Santin AD. PMID: 34875107; PMCID: PMC9465822.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCellsCTClinical Trials
    54. Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence. Nat Genet. 2021 11; 53(11):1553-1563. Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, Bergstrom EN, Atkins J, He Y, Khandekar A, Smith-Byrne K, Carreira C, Gaborieau V, Latimer C, Thomas E, Abnizova I, Bucciarelli PE, Jones D, Teague JW, Abedi-Ardekani B, Serra S, Scoazec JY, Saffar H, Azmoudeh-Ardalan F, Sotoudeh M, Nikmanesh A, Poustchi H, Niavarani A, Gharavi S, Eden M, Richman P, Campos LS, Fitzgerald RC, Ribeiro LF, Soares-Lima SC, Dzamalala C, Mmbaga BT, Shibata T, Menya D, Goldstein AM, Hu N, Malekzadeh R, Fazel A, McCormack V, McKay J, Perdomo S, Scelo G, Chanudet E, Humphreys L, Alexandrov LB, Brennan P, Stratton MR. PMID: 34663923.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    55. Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions. JCI Insight. 2021 09 08; 6(17). Gutkind JS, Molinolo AA, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov LB, Wuertz BR, Ondrey FG, Laronde D, Rock LD, Rosin M, Coffey C, Butler VD, Bengtson L, Hsu CH, Bauman JE, Hewitt SM, Cohen EE, Chow HS, Lippman SM, Szabo E. PMID: 34255745; PMCID: PMC8492350.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    56. Genomic and evolutionary classification of lung cancer in never smokers. Nat Genet. 2021 09; 53(9):1348-1359. Zhang T, Joubert P, Ansari-Pour N, Zhao W, Hoang PH, Lokanga R, Moye AL, Rosenbaum J, Gonzalez-Perez A, Martínez-Jiménez F, Castro A, Muscarella LA, Hofman P, Consonni D, Pesatori AC, Kebede M, Li M, Gould Rothberg BE, Peneva I, Schabath MB, Poeta ML, Costantini M, Hirsch D, Heselmeyer-Haddad K, Hutchinson A, Olanich M, Lawrence SM, Lenz P, Duggan M, Bhawsar PMS, Sang J, Kim J, Mendoza L, Saini N, Klimczak LJ, Islam SMA, Otlu B, Khandekar A, Cole N, Stewart DR, Choi J, Brown KM, Caporaso NE, Wilson SH, Pommier Y, Lan Q, Rothman N, Almeida JS, Carter H, Ried T, Kim CF, Lopez-Bigas N, Garcia-Closas M, Shi J, Bossé Y, Zhu B, Gordenin DA, Alexandrov LB, Chanock SJ, Wedge DC, Landi MT. PMID: 34493867; PMCID: PMC8432745.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    57. Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures. DNA Repair (Amst). 2021 Nov; 107:103200. Abbasi A, Alexandrov LB. PMID: 34411908; PMCID: PMC9478565.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    58. Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival. Nat Commun. 2021 07 23; 12(1):4496. Anderson ND, Babichev Y, Fuligni F, Comitani F, Layeghifard M, Venier RE, Dentro SC, Maheshwari A, Guram S, Wunker C, Thompson JD, Yuki KE, Hou H, Zatzman M, Light N, Bernardini MQ, Wunder JS, Andrulis IL, Ferguson P, Razak ARA, Swallow CJ, Dowling JJ, Al-Awar RS, Marcellus R, Rouzbahman M, Gerstung M, Durocher D, Alexandrov LB, Dickson BC, Gladdy RA, Shlien A. PMID: 34301934; PMCID: PMC8302638.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    59. Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers. Am J Epidemiol. 2021 06 01; 190(6):962-976. Landi MT, Synnott NC, Rosenbaum J, Zhang T, Zhu B, Shi J, Zhao W, Kebede M, Sang J, Choi J, Mendoza L, Pacheco M, Hicks B, Caporaso NE, Abubakar M, Gordenin DA, Wedge DC, Alexandrov LB, Rothman N, Lan Q, Garcia-Closas M, Chanock SJ. PMID: 33712835; PMCID: PMC8316614.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    60. Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). William WN, Zhao X, Bianchi JJ, Lin HY, Cheng P, Lee JJ, Carter H, Alexandrov LB, Abraham JP, Spetzler DB, Dubinett SM, Cleveland DW, Cavenee W, Davoli T, Lippman SM. PMID: 33952700; PMCID: PMC8126856.
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    61. A phase II evaluation of pembrolizumab in recurrent microsatellite instability-high (MSI-H) endometrial cancer patients with Lynch-like versus MLH-1 methylated characteristics (NCT02899793). Ann Oncol. 2021 08; 32(8):1045-1046. Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi DA, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon-Rosario J, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin J, Choi J, Santin AD. PMID: 33932502; PMCID: PMC9465821.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    62. Integrated mutational landscape analysis of uterine leiomyosarcomas. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. PMID: 33876771; PMCID: PMC8053980.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    63. Unraveling the genomic landscape of colorectal cancer through mutational signatures. Adv Cancer Res. 2021; 151:385-424. Díaz-Gay M, Alexandrov LB. PMID: 34148618.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    64. Synchronous, Yet Genomically Distinct, GIST Offer New Insights Into Precise Targeting of Tumor Driver Mutations. JCO Precis Oncol. 2021; 5. Makris EA, Sharma AK, Bergstrom EN, Xu X, de la Torre J, Banerjee S, Nguyen V, Hosseini M, Burgoyne A, Harismendy O, Alexandrov LB, Sicklick JK. PMID: 34250403; PMCID: PMC8232556.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    65. Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Rep. 2021 01 26; 34(4):108670. Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. PMID: 33503434; PMCID: PMC8477897.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    66. St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem. Cancer Discov. 2021 05; 11(5):1082-1099. McLeod C, Gout AM, Zhou X, Thrasher A, Rahbarinia D, Brady SW, Macias M, Birch K, Finkelstein D, Sunny J, Mudunuri R, Orr BA, Treadway M, Davidson B, Ard TK, Chiao A, Swistak A, Wiggins S, Foy S, Wang J, Sioson E, Wang S, Michael JR, Liu Y, Ma X, Patel A, Edmonson MN, Wilkinson MR, Frantz AM, Chang TC, Tian L, Lei S, Islam SMA, Meyer C, Thangaraj N, Tater P, Kandali V, Ma S, Nguyen T, Serang O, McGuire I, Robison N, Gentry D, Tang X, Palmer LE, Wu G, Suh E, Tanner L, McMurry J, Lear M, Pappo AS, Wang Z, Wilson CL, Cheng Y, Meshinchi S, Alexandrov LB, Weiss MJ, Armstrong GT, Robison LL, Yasui Y, Nichols KE, Ellison DW, Bangur C, Mullighan CG, Baker SJ, Dyer MA, Miller G, Newman S, Rusch M, Daly R, Perry K, Downing JR, Zhang J. PMID: 33408242; PMCID: PMC8102307.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    67. Bioinformatic Methods to Identify Mutational Signatures in Cancer. Methods Mol Biol. 2021; 2185:447-473. Islam SMA, Alexandrov LB. PMID: 33165866.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    68. Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator. BMC Bioinformatics. 2020 Oct 07; 21(1):438. Bergstrom EN, Barnes M, Martincorena I, Alexandrov LB. PMID: 33028213; PMCID: PMC7539472.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    69. The mutational signature profile of known and suspected human carcinogens in mice. Nat Genet. 2020 11; 52(11):1189-1197. Riva L, Pandiri AR, Li YR, Droop A, Hewinson J, Quail MA, Iyer V, Shepherd R, Herbert RA, Campbell PJ, Sills RC, Alexandrov LB, Balmain A, Adams DJ. PMID: 32989322; PMCID: PMC7610456.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    70. Strength of immune selection in tumors varies with sex and age. Nat Commun. 2020 08 17; 11(1):4128. Castro A, Pyke RM, Zhang X, Thompson WK, Day CP, Alexandrov LB, Zanetti M, Carter H. PMID: 32807809; PMCID: PMC7431859.
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    71. Author Correction: The evolutionary history of lethal metastatic prostate cancer. Nature. 2020 Aug; 584(7820):E18. Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JMC, Papaemmanuil E, Brewer DS, Kallio HML, Hägnäs G, Annala M, Kivinummi K, Goody V, Latimer C, O'Meara S, Dawson KJ, Isaacs W, Emmert-Buck MR, Nykter M, Foster C, Kote-Jarai Z, Easton D, Whitaker HC, ICGC Prostate UK Group*, Neal DE, Cooper CS, Eeles RA, Visakorpi T, Campbell PJ, McDermott U, Wedge DC, Bova GS. PMID: 32728210.
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    72. The genomic and epigenomic evolutionary history of papillary renal cell carcinomas. Nat Commun. 2020 06 18; 11(1):3096. Zhu B, Poeta ML, Costantini M, Zhang T, Shi J, Sentinelli S, Zhao W, Pompeo V, Cardelli M, Alexandrov BS, Otlu B, Hua X, Jones K, Brodie S, Dabrowska ME, Toro JR, Yeager M, Wang M, Hicks B, Alexandrov LB, Brown KM, Wedge DC, Chanock S, Fazio VM, Gallucci M, Landi MT. PMID: 32555180; PMCID: PMC7303129.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    73. Timing the initiation of multiple myeloma. Nat Commun. 2020 04 21; 11(1):1917. Rustad EH, Yellapantula V, Leongamornlert D, Bolli N, Ledergor G, Nadeu F, Angelopoulos N, Dawson KJ, Mitchell TJ, Osborne RJ, Ziccheddu B, Carniti C, Montefusco V, Corradini P, Anderson KC, Moreau P, Papaemmanuil E, Alexandrov LB, Puente XS, Campo E, Siebert R, Avet-Loiseau H, Landgren O, Munshi N, Campbell PJ, Maura F. PMID: 32317634; PMCID: PMC7174344.
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    74. Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells. Nucleic Acids Res. 2020 02 28; 48(4):1941-1953. Moreno NC, de Souza TA, Garcia CCM, Ruiz NQ, Corradi C, Castro LP, Munford V, Ienne S, Alexandrov LB, Menck CFM. PMID: 31853541; PMCID: PMC7038989.
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    75. The repertoire of mutational signatures in human cancer. Nature. 2020 02; 578(7793):94-101. Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium. PMID: 32025018; PMCID: PMC7054213.
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    76. Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice. Nat Commun. 2020 01 20; 11(1):394. Rose Li Y, Halliwill KD, Adams CJ, Iyer V, Riva L, Mamunur R, Jen KY, Del Rosario R, Fredlund E, Hirst G, Alexandrov LB, Adams D, Balmain A. PMID: 31959748; PMCID: PMC6971050.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsPHPublic Health
    77. The Association of Modifiable Breast Cancer Risk Factors and Somatic Genomic Alterations in Breast Tumors: The Cancer Genome Atlas Network. Cancer Epidemiol Biomarkers Prev. 2020 03; 29(3):599-605. Heng YJ, Hankinson SE, Wang J, Alexandrov LB, Ambrosone CB, de Andrade VP, Brufsky AM, Couch FJ, King TA, Modugno F, Vachon CM, Eliassen AH, Tamimi RM, Kraft P. PMID: 31932411; PMCID: PMC7060119.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    78. Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma. Nat Genet. 2020 01; 52(1):74-83. Noorani A, Li X, Goddard M, Crawte J, Alexandrov LB, Secrier M, Eldridge MD, Bower L, Weaver J, Lao-Sirieix P, Martincorena I, Debiram-Beecham I, Grehan N, MacRae S, Malhotra S, Miremadi A, Thomas T, Galbraith S, Petersen L, Preston SD, Gilligan D, Hindmarsh A, Hardwick RH, Stratton MR, Wedge DC, Fitzgerald RC. PMID: 31907488; PMCID: PMC7100916.
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    79. Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood. 2020 01 02; 135(1):41-55. Li B, Brady SW, Ma X, Shen S, Zhang Y, Li Y, Szlachta K, Dong L, Liu Y, Yang F, Wang N, Flasch DA, Myers MA, Mulder HL, Ding L, Liu Y, Tian L, Hagiwara K, Xu K, Zhou X, Sioson E, Wang T, Yang L, Zhao J, Zhang H, Shao Y, Sun H, Sun L, Cai J, Sun HY, Lin TN, Du L, Li H, Rusch M, Edmonson MN, Easton J, Zhu X, Zhang J, Cheng C, Raphael BJ, Tang J, Downing JR, Alexandrov LB, Zhou BS, Pui CH, Yang JJ, Zhang J. PMID: 31697823; PMCID: PMC6940198.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    80. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    81. Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4. Nat Commun. 2019 12 05; 10(1):5546. Wang Z, Wu VH, Allevato MM, Gilardi M, He Y, Luis Callejas-Valera J, Vitale-Cross L, Martin D, Amornphimoltham P, Mcdermott J, Yung BS, Goto Y, Molinolo AA, Sharabi AB, Cohen EEW, Chen Q, Lyons JG, Alexandrov LB, Gutkind JS. PMID: 31804466; PMCID: PMC6895221.
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    82. Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22730-22736. Zammataro L, Lopez S, Bellone S, Pettinella F, Bonazzoli E, Perrone E, Zhao S, Menderes G, Altwerger G, Han C, Zeybek B, Bianchi A, Manzano A, Manara P, Cocco E, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Angioli R, Raspagliesi F, Scambia G, Choi J, Dong W, Bilguvar K, Alexandrov LB, Silasi DA, Huang GS, Ratner E, Azodi M, Schwartz PE, Pirazzoli V, Stiegler AL, Boggon TJ, Lifton RP, Schlessinger J, Santin AD. PMID: 31624127; PMCID: PMC6842590.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    83. SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events. BMC Genomics. 2019 Aug 30; 20(1):685. Bergstrom EN, Huang MN, Mahto U, Barnes M, Stratton MR, Rozen SG, Alexandrov LB. PMID: 31470794; PMCID: PMC6717374.
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    84. Somatic evolution and global expansion of an ancient transmissible cancer lineage. Science. 2019 08 02; 365(6452). Baez-Ortega A, Gori K, Strakova A, Allen JL, Allum KM, Bansse-Issa L, Bhutia TN, Bisson JL, Briceño C, Castillo Domracheva A, Corrigan AM, Cran HR, Crawford JT, Davis E, de Castro KF, B de Nardi A, de Vos AP, Delgadillo Keenan L, Donelan EM, Espinoza Huerta AR, Faramade IA, Fazil M, Fotopoulou E, Fruean SN, Gallardo-Arrieta F, Glebova O, Gouletsou PG, Häfelin Manrique RF, Henriques JJGP, Horta RS, Ignatenko N, Kane Y, King C, Koenig D, Krupa A, Kruzeniski SJ, Kwon YM, Lanza-Perea M, Lazyan M, Lopez Quintana AM, Losfelt T, Marino G, Martínez Castañeda S, Martínez-López MF, Meyer M, Migneco EJ, Nakanwagi B, Neal KB, Neunzig W, Ní Leathlobhair M, Nixon SJ, Ortega-Pacheco A, Pedraza-Ordoñez F, Peleteiro MC, Polak K, Pye RJ, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Sherlock AG, Stammnitz M, Steenland-Smit AE, Svitich A, Tapia Martínez LJ, Thoya Ngoka I, Torres CG, Tudor EM, van der Wel MG, Vitalaru BA, Vural SA, Walkinton O, Wang J, Wehrle-Martinez AS, Widdowson SAE, Stratton MR, Alexandrov LB, Martincorena I, Murchison EP. PMID: 31371581; PMCID: PMC7116271.
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    85. Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz028. Yost S, Ruark E, Alexandrov LB, Rahman N. PMID: 31360904; PMCID: PMC6649772.
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    86. Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation. Nat Commun. 2019 04 15; 10(1):1749. Brinkman AB, Nik-Zainal S, Simmer F, Rodríguez-González FG, Smid M, Alexandrov LB, Butler A, Martin S, Davies H, Glodzik D, Zou X, Ramakrishna M, Staaf J, Ringnér M, Sieuwerts A, Ferrari A, Morganella S, Fleischer T, Kristensen V, Gut M, van de Vijver MJ, Børresen-Dale AL, Richardson AL, Thomas G, Gut IG, Martens JWM, Foekens JA, Stratton MR, Stunnenberg HG. PMID: 30988298; PMCID: PMC6465362.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    87. Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways. Cancer Cell. 2019 03 18; 35(3):441-456.e8. Steele CD, Tarabichi M, Oukrif D, Webster AP, Ye H, Fittall M, Lombard P, Martincorena I, Tarpey PS, Collord G, Haase K, Strauss SJ, Berisha F, Vaikkinen H, Dhami P, Jansen M, Behjati S, Amary MF, Tirabosco R, Feber A, Campbell PJ, Alexandrov LB, Van Loo P, Flanagan AM, Pillay N. PMID: 30889380; PMCID: PMC6428691.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    88. Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis. Cell. 2019 03 07; 176(6):1282-1294.e20. Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC, Grossmann S, Dawson KJ, Ju YS, Iorio F, Tubio JMC, Koh CC, Georgakopoulos-Soares I, Rodríguez-Martín B, Otlu B, O'Meara S, Butler AP, Menzies A, Bhosle SG, Raine K, Jones DR, Teague JW, Beal K, Latimer C, O'Neill L, Zamora J, Anderson E, Patel N, Maddison M, Ng BL, Graham J, Garnett MJ, McDermott U, Nik-Zainal S, Campbell PJ, Stratton MR. PMID: 30849372; PMCID: PMC6424819.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansCells
    89. Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. 2019 02; 566(7742):E1. Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C, Dirix L, Dronov S, Fatima A, Foekens JA, Gerstung M, Hooijer GKJ, Jang SJ, Jones DR, Kim HY, King TA, Krishnamurthy S, Lee HJ, Lee JY, Li Y, McLaren S, Menzies A, Mustonen V, O'Meara S, Pauporté I, Pivot X, Purdie CA, Raine K, Ramakrishnan K, Rodríguez-González FG, Romieu G, Sieuwerts AM, Simpson PT, Shepherd R, Stebbings L, Stefansson OA, Teague J, Tommasi S, Treilleux I, Van den Eynden GG, Vermeulen P, Vincent-Salomon A, Yates L, Caldas C, Van't Veer L, Tutt A, Knappskog S, Tan BKT, Jonkers J, Borg Å, Ueno NT, Sotiriou C, Viari A, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JWM, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Stratton MR. PMID: 30659290.
      View in: PubMed   Mentions: 8     Fields:    
    90. The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. Mol Cancer Res. 2019 04; 17(4):895-906. Brady SW, Ma X, Bahrami A, Satas G, Wu G, Newman S, Rusch M, Putnam DK, Mulder HL, Yergeau DA, Edmonson MN, Easton J, Alexandrov LB, Chen X, Mardis ER, Wilson RK, Downing JR, Pappo AS, Raphael BJ, Dyer MA, Zhang J. PMID: 30651371; PMCID: PMC8518028.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    91. Stem cell replication, somatic mutations and role of randomness in the development of cancer. Eur J Epidemiol. 2019 May; 34(5):439-445. Perduca V, Alexandrov LB, Kelly-Irving M, Delpierre C, Omichessan H, Little MP, Vineis P, Severi G. PMID: 30623292; PMCID: PMC10654895.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    92. Nonnegative/Binary matrix factorization with a D-Wave quantum annealer. PLoS One. 2018; 13(12):e0206653. O'Malley D, Vesselinov VV, Alexandrov BS, Alexandrov LB. PMID: 30532243; PMCID: PMC6287781.
      View in: PubMed   Mentions: 12     Fields:    
    93. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485; PMCID: PMC6196518.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    94. The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nat Commun. 2018 09 10; 9(1):3667. Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J, Hogan S, Spender LC, South AP, Stratton M, Chelala C, Harwood CA, Proby CM, Leigh IM. PMID: 30202019; PMCID: PMC6131170.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    95. Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science. 2018 08 31; 361(6405). Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE, Anaka M, Davidson S, Zarrei M, Id Said B, Schreiner LC, Marchand R, Sitter J, Gokgoz N, Brunga L, Graham GT, Fullam A, Pillay N, Toretsky JA, Yoshida A, Shibata T, Metzler M, Somers GR, Scherer SW, Flanagan AM, Campbell PJ, Schiffman JD, Shago M, Alexandrov LB, Wunder JS, Andrulis IL, Malkin D, Behjati S, Shlien A. PMID: 30166462; PMCID: PMC6176908.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    96. APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2018 08 22; 10(455). Cho RJ, Alexandrov LB, den Breems NY, Atanasova VS, Farshchian M, Purdom E, Nguyen TN, Coarfa C, Rajapakshe K, Prisco M, Sahu J, Tassone P, Greenawalt EJ, Collisson EA, Wu W, Yao H, Su X, Guttmann-Gruber C, Hofbauer JP, Hashmi R, Fuentes I, Benz SC, Golovato J, Ehli EA, Davis CM, Davies GE, Covington KR, Murrell DF, Salas-Alanis JC, Palisson F, Bruckner AL, Robinson W, Has C, Bruckner-Tuderman L, Titeux M, Jonkman MF, Rashidghamat E, Lwin SM, Mellerio JE, McGrath JA, Bauer JW, Hovnanian A, Tsai KY, South AP. PMID: 30135250.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    97. Genomic patterns of progression in smoldering multiple myeloma. Nat Commun. 2018 08 22; 9(1):3363. Bolli N, Maura F, Minvielle S, Gloznik D, Szalat R, Fullam A, Martincorena I, Dawson KJ, Samur MK, Zamora J, Tarpey P, Davies H, Fulciniti M, Shammas MA, Tai YT, Magrangeas F, Moreau P, Corradini P, Anderson K, Alexandrov L, Wedge DC, Avet-Loiseau H, Campbell P, Munshi N. PMID: 30135448; PMCID: PMC6105687.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    98. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nat Genet. 2018 05; 50(5):682-692. Wedge DC, Gundem G, Mitchell T, Woodcock DJ, Martincorena I, Ghori M, Zamora J, Butler A, Whitaker H, Kote-Jarai Z, Alexandrov LB, Van Loo P, Massie CE, Dentro S, Warren AY, Verrill C, Berney DM, Dennis N, Merson S, Hawkins S, Howat W, Lu YJ, Lambert A, Kay J, Kremeyer B, Karaszi K, Luxton H, Camacho N, Marsden L, Edwards S, Matthews L, Bo V, Leongamornlert D, McLaren S, Ng A, Yu Y, Zhang H, Dadaev T, Thomas S, Easton DF, Ahmed M, Bancroft E, Fisher C, Livni N, Nicol D, Tavaré S, Gill P, Greenman C, Khoo V, Van As N, Kumar P, Ogden C, Cahill D, Thompson A, Mayer E, Rowe E, Dudderidge T, Gnanapragasam V, Shah NC, Raine K, Jones D, Menzies A, Stebbings L, Teague J, Hazell S, Corbishley C, CAMCAP Study Group, de Bono J, Attard G, Isaacs W, Visakorpi T, Fraser M, Boutros PC, Bristow RG, Workman P, Sander C, TCGA Consortium, Hamdy FC, Futreal A, McDermott U, Al-Lazikani B, Lynch AG, Bova GS, Foster CS, Brewer DS, Neal DE, Cooper CS, Eeles RA. PMID: 29662167; PMCID: PMC6372064.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    99. Intra-tumour diversification in colorectal cancer at the single-cell level. Nature. 2018 04; 556(7702):457-462. Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble SJ, Alder C, van de Wetering M, Campbell PJ, Stratton MR, Clevers H. PMID: 29643510.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansCells
    100. The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. Cancer Cell. 2018 04 09; 33(4):607-619.e15. Stammnitz MR, Coorens THH, Gori KC, Hayes D, Fu B, Wang J, Martin-Herranz DE, Alexandrov LB, Baez-Ortega A, Barthorpe S, Beck A, Giordano F, Knowles GW, Kwon YM, Hall G, Price S, Pye RJ, Tubio JMC, Siddle HVT, Sohal SS, Woods GM, McDermott U, Yang F, Garnett MJ, Ning Z, Murchison EP. PMID: 29634948; PMCID: PMC5896245.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    101. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. Nat Commun. 2018 03 13; 9(1):1048. George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Müller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, De Reynies A, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmüller J, Becker C, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soloway MG, Wilkerson MD, Cun Y, McKay JD, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Lemaitre N, Soltermann A, Weder W, Tischler V, Brustugun OT, Lund-Iversen M, Helland Å, Solberg S, Ansén S, Wright G, Solomon B, Roz L, Pastorino U, Petersen I, Clement JH, Sänger J, Wolf J, Vingron M, Zander T, Perner S, Travis WD, Haas SA, Olivier M, Foll M, Büttner R, Hayes DN, Brambilla E, Fernandez-Cuesta L, Thomas RK. PMID: 29535388; PMCID: PMC5849599.
      View in: PubMed   Mentions: 149     Fields:    Translation:Humans
    102. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. Nature. 2018 03 15; 555(7696):371-376. Ma X, Liu Y, Liu Y, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J. PMID: 29489755; PMCID: PMC5854542.
      View in: PubMed   Mentions: 428     Fields:    Translation:Humans
    103. Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines. Leukemia. 2018 04; 32(4):1044-1048. Maura F, Petljak M, Lionetti M, Cifola I, Liang W, Pinatel E, Alexandrov LB, Fullam A, Martincorena I, Dawson KJ, Angelopoulos N, Samur MK, Szalat R, Zamora J, Tarpey P, Davies H, Corradini P, Anderson KC, Minvielle S, Neri A, Avet-Loiseau H, Keats J, Campbell PJ, Munshi NC, Bolli N. PMID: 29209044; PMCID: PMC5886048.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    104. Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. Nat Genet. 2017 10 27; 49(11):1661. Glodzik D, Morganella S, Davies H, Simpson PT, Li Y, Zou X, Diez-Perez J, Staaf J, Alexandrov LB, Smid M, Brinkman AB, Rye IH, Russnes H, Raine K, Purdie CA, Lakhani SR, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JWM, Børresen-Dale AL, Richardson AL, Kong G, Viari A, Easton D, Evan G, Campbell PJ, Stratton MR, Nik-Zainal S. PMID: 29074948.
      View in: PubMed   Mentions: 1     Fields:    
    105. The driver landscape of sporadic chordoma. Nat Commun. 2017 10 12; 8(1):890. Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP, Teague JW, Shlien A, Futreal PA, Shah S, Bashashati A, Jamshidi F, Nielsen TO, Huntsman D, Baumhoer D, Brandner S, Wunder J, Dickson B, Cogswell P, Sommer J, Phillips JJ, Amary MF, Tirabosco R, Pillay N, Yip S, Stratton MR, Flanagan AM, Campbell PJ. PMID: 29026114; PMCID: PMC5638846.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    106. Evaluating the role of coherent delocalized phonon-like modes in DNA cyclization. Sci Rep. 2017 08 29; 7(1):9731. Alexandrov LB, Rasmussen KØ, Bishop AR, Alexandrov BS. PMID: 28851939; PMCID: PMC5575098.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    107. Genomic Evolution of Breast Cancer Metastasis and Relapse. Cancer Cell. 2017 08 14; 32(2):169-184.e7. Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S, Martincorena I, Alexandrov LB, Van Loo P, Haugland HK, Lilleng PK, Gundem G, Gerstung M, Pappaemmanuil E, Gazinska P, Bhosle SG, Jones D, Raine K, Mudie L, Latimer C, Sawyer E, Desmedt C, Sotiriou C, Stratton MR, Sieuwerts AM, Lynch AG, Martens JW, Richardson AL, Tutt A, Lønning PE, Campbell PJ. PMID: 28810143; PMCID: PMC5559645.
      View in: PubMed   Mentions: 330     Fields:    Translation:Humans
    108. Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Sci Rep. 2017 08 03; 7(1):7199. Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H. PMID: 28775312; PMCID: PMC5543110.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    109. Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discov. 2017 10; 7(10):1116-1135. Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, Myint SS, Thanan R, Nagarajan S, Lim WK, Ng CCY, Boot A, Liu M, Ong CK, Rajasegaran V, Lie S, Lim AST, Lim TH, Tan J, Loh JL, McPherson JR, Khuntikeo N, Bhudhisawasdi V, Yongvanit P, Wongkham S, Totoki Y, Nakamura H, Arai Y, Yamasaki S, Chow PK, Chung AYF, Ooi LLPJ, Lim KH, Dima S, Duda DG, Popescu I, Broet P, Hsieh SY, Yu MC, Scarpa A, Lai J, Luo DX, Carvalho AL, Vettore AL, Rhee H, Park YN, Alexandrov LB, Gordân R, Rozen SG, Shibata T, Pairojkul C, Teh BT, Tan P. PMID: 28667006; PMCID: PMC5628134.
      View in: PubMed   Mentions: 367     Fields:    Translation:HumansCells
    110. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. Nat Commun. 2017 06 23; 8:15936. Behjati S, Tarpey PS, Haase K, Ye H, Young MD, Alexandrov LB, Farndon SJ, Collord G, Wedge DC, Martincorena I, Cooke SL, Davies H, Mifsud W, Lidgren M, Martin S, Latimer C, Maddison M, Butler AP, Teague JW, Pillay N, Shlien A, McDermott U, Futreal PA, Baumhoer D, Zaikova O, Bjerkehagen B, Myklebost O, Amary MF, Tirabosco R, Van Loo P, Stratton MR, Flanagan AM, Campbell PJ. PMID: 28643781; PMCID: PMC5490007.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    111. Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma. JAMA Oncol. 2017 Jun 01; 3(6):774-783. Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S. PMID: 27768182; PMCID: PMC5824324.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    112. Whole-genome landscapes of major melanoma subtypes. Nature. 2017 05 11; 545(7653):175-180. Hayward NK, Wilmott JS, Waddell N, Johansson PA, Field MA, Nones K, Patch AM, Kakavand H, Alexandrov LB, Burke H, Jakrot V, Kazakoff S, Holmes O, Leonard C, Sabarinathan R, Mularoni L, Wood S, Xu Q, Waddell N, Tembe V, Pupo GM, De Paoli-Iseppi R, Vilain RE, Shang P, Lau LMS, Dagg RA, Schramm SJ, Pritchard A, Dutton-Regester K, Newell F, Fitzgerald A, Shang CA, Grimmond SM, Pickett HA, Yang JY, Stretch JR, Behren A, Kefford RF, Hersey P, Long GV, Cebon J, Shackleton M, Spillane AJ, Saw RPM, López-Bigas N, Pearson JV, Thompson JF, Scolyer RA, Mann GJ. PMID: 28467829.
      View in: PubMed   Mentions: 542     Fields:    Translation:HumansCells
    113. A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer. EBioMedicine. 2017 Jun; 20:39-49. Viel A, Bruselles A, Meccia E, Fornasarig M, Quaia M, Canzonieri V, Policicchio E, Urso ED, Agostini M, Genuardi M, Lucci-Cordisco E, Venesio T, Martayan A, Diodoro MG, Sanchez-Mete L, Stigliano V, Mazzei F, Grasso F, Giuliani A, Baiocchi M, Maestro R, Giannini G, Tartaglia M, Alexandrov LB, Bignami M. PMID: 28551381; PMCID: PMC5478212.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    114. Precancer Atlas to Drive Precision Prevention Trials. Cancer Res. 2017 04 01; 77(7):1510-1541. Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, Garber JE, Velculescu VE, Disis ML, Wallace DC, Lippman SM. PMID: 28373404; PMCID: PMC6681830.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    115. Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas. J Pathol. 2017 05; 242(1):10-15. Pilati C, Shinde J, Alexandrov LB, Assié G, André T, Hélias-Rodzewicz Z, Ducoudray R, Le Corre D, Zucman-Rossi J, Emile JF, Bertherat J, Letouzé E, Laurent-Puig P. PMID: 28127763.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    116. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo. Nature. 2017 03 30; 543(7647):714-718. Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB, Rahbari R, Wedge DC, Davies HR, Ramakrishna M, Fullam A, Martin S, Alder C, Patel N, Gamble S, O'Meara S, Giri DD, Sauer T, Pinder SE, Purdie CA, Borg Å, Stunnenberg H, van de Vijver M, Tan BK, Caldas C, Tutt A, Ueno NT, van 't Veer LJ, Martens JW, Sotiriou C, Knappskog S, Span PN, Lakhani SR, Eyfjörd JE, Børresen-Dale AL, Richardson A, Thompson AM, Viari A, Hurles ME, Nik-Zainal S, Campbell PJ, Stratton MR. PMID: 28329761; PMCID: PMC6169740.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansCells
    117. Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26. Hum Mol Genet. 2017 03 15; 26(6):1070-1077. Gudmundsson S, Wilbe M, Ekvall S, Ameur A, Cahill N, Alexandrov LB, Virtanen M, Hellström Pigg M, Vahlquist A, Törmä H, Bondeson ML. PMID: 28158657; PMCID: PMC5409067.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    118. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. Nat Genet. 2017 Mar; 49(3):341-348. Glodzik D, Morganella S, Davies H, Simpson PT, Li Y, Zou X, Diez-Perez J, Staaf J, Alexandrov LB, Smid M, Brinkman AB, Rye IH, Russnes H, Raine K, Purdie CA, Lakhani SR, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Viari A, Easton D, Evan G, Campbell PJ, Stratton MR, Nik-Zainal S. PMID: 28112740; PMCID: PMC5988034.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    119. Mutational signatures associated with tobacco smoking in human cancer. Science. 2016 11 04; 354(6312):618-622. Alexandrov LB, Ju YS, Haase K, Van Loo P, Martincorena I, Nik-Zainal S, Totoki Y, Fujimoto A, Nakagawa H, Shibata T, Campbell PJ, Vineis P, Phillips DH, Stratton MR. PMID: 27811275; PMCID: PMC6141049.
      View in: PubMed   Mentions: 486     Fields:    Translation:HumansAnimalsCells
    120. A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns. Nature. 2016 Oct 20; 538(7625):378-382. Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW, Connor AA, Denroche RE, Liang SB, Brown AM, Kim JC, Wang T, Simpson JT, Beck T, Borgida A, Buchner N, Chadwick D, Hafezi-Bakhtiari S, Dick JE, Heisler L, Hollingsworth MA, Ibrahimov E, Jang GH, Johns J, Jorgensen LG, Law C, Ludkovski O, Lungu I, Ng K, Pasternack D, Petersen GM, Shlush LI, Timms L, Tsao MS, Wilson JM, Yung CK, Zogopoulos G, Bartlett JM, Alexandrov LB, Real FX, Cleary SP, Roehrl MH, McPherson JD, Stein LD, Hudson TJ, Campbell PJ, Gallinger S. PMID: 27732578; PMCID: PMC5446075.
      View in: PubMed   Mentions: 251     Fields:    Translation:Humans
    121. Mutational signatures of ionizing radiation in second malignancies. Nat Commun. 2016 09 12; 7:12605. Behjati S, Gundem G, Wedge DC, Roberts ND, Tarpey PS, Cooke SL, Van Loo P, Alexandrov LB, Ramakrishna M, Davies H, Nik-Zainal S, Hardy C, Latimer C, Raine KM, Stebbings L, Menzies A, Jones D, Shepherd R, Butler AP, Teague JW, Jorgensen M, Khatri B, Pillay N, Shlien A, Futreal PA, Badie C, ICGC Prostate Group, McDermott U, Bova GS, Richardson AL, Flanagan AM, Stratton MR, Campbell PJ. PMID: 27615322; PMCID: PMC5027243.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    122. Germline MC1R status influences somatic mutation burden in melanoma. Nat Commun. 2016 07 12; 7:12064. Robles-Espinoza CD, Roberts ND, Chen S, Leacy FP, Alexandrov LB, Pornputtapong N, Halaban R, Krauthammer M, Cui R, Timothy Bishop D, Adams DJ. PMID: 27403562; PMCID: PMC4945874.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    123. Base changes in tumour DNA have the power to reveal the causes and evolution of cancer. Oncogene. 2017 01 12; 36(2):158-167. Hollstein M, Alexandrov LB, Wild CP, Ardin M, Zavadil J. PMID: 27270430; PMCID: PMC5241425.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    124. Understanding mutagenesis through delineation of mutational signatures in human cancer. Carcinogenesis. 2016 06; 37(6):531-40. Petljak M, Alexandrov LB. PMID: 27207657.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    125. The topography of mutational processes in breast cancer genomes. Nat Commun. 2016 May 02; 7:11383. Morganella S, Alexandrov LB, Glodzik D, Zou X, Davies H, Staaf J, Sieuwerts AM, Brinkman AB, Martin S, Ramakrishna M, Butler A, Kim HY, Borg Å, Sotiriou C, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Sale J, Rada C, Stratton MR, Birney E, Nik-Zainal S. PMID: 27136393; PMCID: PMC5001788.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    126. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. 2016 06 02; 534(7605):47-54. Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C, Dirix L, Dronov S, Fatima A, Foekens JA, Gerstung M, Hooijer GK, Jang SJ, Jones DR, Kim HY, King TA, Krishnamurthy S, Lee HJ, Lee JY, Li Y, McLaren S, Menzies A, Mustonen V, O'Meara S, Pauporté I, Pivot X, Purdie CA, Raine K, Ramakrishnan K, Rodríguez-González FG, Romieu G, Sieuwerts AM, Simpson PT, Shepherd R, Stebbings L, Stefansson OA, Teague J, Tommasi S, Treilleux I, Van den Eynden GG, Vermeulen P, Vincent-Salomon A, Yates L, Caldas C, van't Veer L, Tutt A, Knappskog S, Tan BK, Jonkers J, Borg Å, Ueno NT, Sotiriou C, Viari A, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Stratton MR. PMID: 27135926; PMCID: PMC4910866.
      View in: PubMed   Mentions: 1076     Fields:    Translation:HumansCells
    127. Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents. Nat Commun. 2016 Feb 24; 7:10767. Merlevede J, Droin N, Qin T, Meldi K, Yoshida K, Morabito M, Chautard E, Auboeuf D, Fenaux P, Braun T, Itzykson R, de Botton S, Quesnel B, Commes T, Jourdan E, Vainchenker W, Bernard O, Pata-Merci N, Solier S, Gayevskiy V, Dinger ME, Cowley MJ, Selimoglu-Buet D, Meyer V, Artiguenave F, Deleuze JF, Preudhomme C, Stratton MR, Alexandrov LB, Padron E, Ogawa S, Koscielny S, Figueroa M, Solary E. PMID: 26908133; PMCID: PMC4770084.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    128. The role of structural parameters in DNA cyclization. BMC Bioinformatics. 2016 Feb 04; 17:68. Alexandrov LB, Bishop AR, Rasmussen KØ, Alexandrov BS. PMID: 26846597; PMCID: PMC4743258.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    129. Timing, rates and spectra of human germline mutation. Nat Genet. 2016 Feb; 48(2):126-133. Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Turki SA, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, UK10K Consortium, Hurles ME. PMID: 26656846; PMCID: PMC4731925.
      View in: PubMed   Mentions: 287     Fields:    Translation:HumansCells
    130. Understanding the origins of human cancer. Science. 2015 Dec 04; 350(6265):1175. Alexandrov LB. PMID: 26785464.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    131. Clock-like mutational processes in human somatic cells. Nat Genet. 2015 Dec; 47(12):1402-7. Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, Stratton MR. PMID: 26551669; PMCID: PMC4783858.
      View in: PubMed   Mentions: 484     Fields:    Translation:Humans
    132. A mutational signature in gastric cancer suggests therapeutic strategies. Nat Commun. 2015 Oct 29; 6:8683. Alexandrov LB, Nik-Zainal S, Siu HC, Leung SY, Stratton MR. PMID: 26511885; PMCID: PMC4918743.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    133. The genome as a record of environmental exposure. Mutagenesis. 2015 Nov; 30(6):763-70. Nik-Zainal S, Kucab JE, Morganella S, Glodzik D, Alexandrov LB, Arlt VM, Weninger A, Hollstein M, Stratton MR, Phillips DH. PMID: 26443852; PMCID: PMC4637815.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    134. Subclonal diversification of primary breast cancer revealed by multiregion sequencing. Nat Med. 2015 Jul; 21(7):751-9. Yates LR, Gerstung M, Knappskog S, Desmedt C, Gundem G, Van Loo P, Aas T, Alexandrov LB, Larsimont D, Davies H, Li Y, Ju YS, Ramakrishna M, Haugland HK, Lilleng PK, Nik-Zainal S, McLaren S, Butler A, Martin S, Glodzik D, Menzies A, Raine K, Hinton J, Jones D, Mudie LJ, Jiang B, Vincent D, Greene-Colozzi A, Adnet PY, Fatima A, Maetens M, Ignatiadis M, Stratton MR, Sotiriou C, Richardson AL, Lønning PE, Wedge DC, Campbell PJ. PMID: 26099045; PMCID: PMC4500826.
      View in: PubMed   Mentions: 419     Fields:    Translation:HumansCells
    135. Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet. 2015 Jun; 47(6):689. Cooper CS, Eeles R, Wedge DC, Van Loo P, Gundem G, Alexandrov LB, Kremeyer B, Butler A, Lynch AG, Camacho N, Massie CE, Kay J, Luxton HJ, Edwards S, Kote-Jarai Z, Dennis N, Merson S, Leongamornlert D, Zamora J, Corbishley C, Thomas S, Nik-Zainal S, Ramakrishna M, O'Meara S, Matthews L, Clark J, Hurst R, Mithen R, Bristow RG, Boutros PC, Fraser M, Cooke S, Raine K, Jones D, Menzies A, Stebbings L, Hinton J, Teague J, McLaren S, Mudie L, Hardy C, Anderson E, Joseph O, Goody V, Robinson B, Maddison M, Gamble S, Greenman C, Berney D, Hazell S, Livni N, ICGC Prostate Group, Fisher C, Ogden C, Kumar P, Thompson A, Woodhouse C, Nicol D, Mayer E, Dudderidge T, Shah NC, Gnanapragasam V, Voet T, Campbell P, Futreal A, Easton D, Warren AY, Foster CS, Stratton MR, Whitaker HC, McDermott U, Brewer DS, Neal DE. PMID: 26018901.
      View in: PubMed   Mentions: 3     Fields:    
    136. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015 May 22; 348(6237):880-6. Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S, Wedge DC, Fullam A, Alexandrov LB, Tubio JM, Stebbings L, Menzies A, Widaa S, Stratton MR, Jones PH, Campbell PJ. PMID: 25999502; PMCID: PMC4471149.
      View in: PubMed   Mentions: 782     Fields:    Translation:Humans
    137. The evolutionary history of lethal metastatic prostate cancer. Nature. 2015 Apr 16; 520(7547):353-357. Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JMC, Papaemmanuil E, Brewer DS, Kallio HML, Högnäs G, Annala M, Kivinummi K, Goody V, Latimer C, O'Meara S, Dawson KJ, Isaacs W, Emmert-Buck MR, Nykter M, Foster C, Kote-Jarai Z, Easton D, Whitaker HC, ICGC Prostate Group, Neal DE, Cooper CS, Eeles RA, Visakorpi T, Campbell PJ, McDermott U, Wedge DC, Bova GS. PMID: 25830880; PMCID: PMC4413032.
      View in: PubMed   Mentions: 637     Fields:    Translation:HumansCells
    138. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer. Nat Commun. 2015 Apr 01; 6:6605. Hong MK, Macintyre G, Wedge DC, Van Loo P, Patel K, Lunke S, Alexandrov LB, Sloggett C, Cmero M, Marass F, Tsui D, Mangiola S, Lonie A, Naeem H, Sapre N, Phal PM, Kurganovs N, Chin X, Kerger M, Warren AY, Neal D, Gnanapragasam V, Rosenfeld N, Pedersen JS, Ryan A, Haviv I, Costello AJ, Corcoran NM, Hovens CM. PMID: 25827447; PMCID: PMC4396364.
      View in: PubMed   Mentions: 177     Fields:    Translation:Humans
    139. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 2015 May; 47(5):505-511. Schulze K, Imbeaud S, Letouzé E, Alexandrov LB, Calderaro J, Rebouissou S, Couchy G, Meiller C, Shinde J, Soysouvanh F, Calatayud AL, Pinyol R, Pelletier L, Balabaud C, Laurent A, Blanc JF, Mazzaferro V, Calvo F, Villanueva A, Nault JC, Bioulac-Sage P, Stratton MR, Llovet JM, Zucman-Rossi J. PMID: 25822088; PMCID: PMC4587544.
      View in: PubMed   Mentions: 806     Fields:    Translation:HumansCells
    140. SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene. 2015 Nov 12; 34(46):5699-708. Kanu N, Grönroos E, Martinez P, Burrell RA, Yi Goh X, Bartkova J, Maya-Mendoza A, Mistrík M, Rowan AJ, Patel H, Rabinowitz A, East P, Wilson G, Santos CR, McGranahan N, Gulati S, Gerlinger M, Birkbak NJ, Joshi T, Alexandrov LB, Stratton MR, Powles T, Matthews N, Bates PA, Stewart A, Szallasi Z, Larkin J, Bartek J, Swanton C. PMID: 25728682; PMCID: PMC4660036.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    141. Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet. 2015 Apr; 47(4):367-372. Cooper CS, Eeles R, Wedge DC, Van Loo P, Gundem G, Alexandrov LB, Kremeyer B, Butler A, Lynch AG, Camacho N, Massie CE, Kay J, Luxton HJ, Edwards S, Kote-Jarai Z, Dennis N, Merson S, Leongamornlert D, Zamora J, Corbishley C, Thomas S, Nik-Zainal S, O'Meara S, Matthews L, Clark J, Hurst R, Mithen R, Bristow RG, Boutros PC, Fraser M, Cooke S, Raine K, Jones D, Menzies A, Stebbings L, Hinton J, Teague J, McLaren S, Mudie L, Hardy C, Anderson E, Joseph O, Goody V, Robinson B, Maddison M, Gamble S, Greenman C, Berney D, Hazell S, Livni N, ICGC Prostate Group, Fisher C, Ogden C, Kumar P, Thompson A, Woodhouse C, Nicol D, Mayer E, Dudderidge T, Shah NC, Gnanapragasam V, Voet T, Campbell P, Futreal A, Easton D, Warren AY, Foster CS, Stratton MR, Whitaker HC, McDermott U, Brewer DS, Neal DE. PMID: 25730763; PMCID: PMC4380509.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansCells
    142. Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma. Leukemia. 2015 Jul; 29(7):1612-5. Wagener R, Alexandrov LB, Montesinos-Rongen M, Schlesner M, Haake A, Drexler HG, Richter J, Bignell GR, McDermott U, Siebert R. PMID: 25650088.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    143. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nat Genet. 2015 Mar; 47(3):257-62. Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, Meier B, Gerstung M, Hong Y, Merino DM, Ramakrishna M, Remke M, Arnold R, Panigrahi GB, Thakkar NP, Hodel KP, Henninger EE, Göksenin AY, Bakry D, Charames GS, Druker H, Lerner-Ellis J, Mistry M, Dvir R, Grant R, Elhasid R, Farah R, Taylor GP, Nathan PC, Alexander S, Ben-Shachar S, Ling SC, Gallinger S, Constantini S, Dirks P, Huang A, Scherer SW, Grundy RG, Durno C, Aronson M, Gartner A, Meyn MS, Taylor MD, Pursell ZF, Pearson CE, Malkin D, Futreal PA, Stratton MR, Bouffet E, Hawkins C, Campbell PJ, Tabori U, Biallelic Mismatch Repair Deficiency Consortium. PMID: 25642631.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    144. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife. 2014 Oct 01; 3. Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ. PMID: 25271376; PMCID: PMC4371858.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    145. Fast randomization of large genomic datasets while preserving alteration counts. Bioinformatics. 2014 Sep 01; 30(17):i617-23. Gobbi A, Iorio F, Dawson KJ, Wedge DC, Tamborero D, Alexandrov LB, Lopez-Bigas N, Garnett MJ, Jurman G, Saez-Rodriguez J. PMID: 25161255; PMCID: PMC4147926.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    146. Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. Science. 2014 Aug 01; 345(6196):1251343. Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP, Nik-Zainal S, Alexandrov L, Behjati S, Yates LR, Bolli N, Mudie L, Hardy C, Martin S, McLaren S, O'Meara S, Anderson E, Maddison M, Gamble S, Foster C, Warren AY, Whitaker H, Brewer D, Eeles R, Cooper C, Neal D, Lynch AG, Visakorpi T, Isaacs WB, Veer LV, Caldas C, Desmedt C, Sotiriou C, Aparicio S, Foekens JA, Eyfjörd JE, Lakhani SR, Thomas G, Myklebost O, Span PN, Børresen-Dale AL, Richardson AL, Van de Vijver M, Vincent-Salomon A, Van den Eynden GG, Flanagan AM, Futreal PA, Janes SM, Bova GS, Stratton MR, McDermott U, Campbell PJ, ICGC Breast Cancer Group, ICGC Bone Cancer Group, ICGC Prostate Cancer Group. PMID: 25082706; PMCID: PMC4380235.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansCells
    147. C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Genome Res. 2014 Oct; 24(10):1624-36. Meier B, Cooke SL, Weiss J, Bailly AP, Alexandrov LB, Marshall J, Raine K, Maddison M, Anderson E, Stratton MR, Gartner A, Campbell PJ. PMID: 25030888; PMCID: PMC4199376.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    148. Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature. 2014 Sep 18; 513(7518):422-425. Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, Robinson B, Nik-Zainal S, Campbell P, Goldman N, van de Wetering M, Cuppen E, Clevers H, Stratton MR. PMID: 25043003; PMCID: PMC4227286.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    149. Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer. Nat Genet. 2014 May; 46(5):487-91. Nik-Zainal S, Wedge DC, Alexandrov LB, Petljak M, Butler AP, Bolli N, Davies HR, Knappskog S, Martin S, Papaemmanuil E, Ramakrishna M, Shlien A, Simonic I, Xue Y, Tyler-Smith C, Campbell PJ, Stratton MR. PMID: 24728294; PMCID: PMC4137149.
      View in: PubMed   Mentions: 171     Fields:    Translation:Humans
    150. Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage. Science. 2014 Jan 24; 343(6169):437-440. Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I, Ning Z, Tubio JMC, Werner EI, Allen J, De Nardi AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR. PMID: 24458646; PMCID: PMC3918581.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    151. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet. 2014 Feb; 46(2):116-25. Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J, Alexandrov LB, Van Loo P, Cooke SL, Marshall J, Martincorena I, Hinton J, Gundem G, van Delft FW, Nik-Zainal S, Jones DR, Ramakrishna M, Titley I, Stebbings L, Leroy C, Menzies A, Gamble J, Robinson B, Mudie L, Raine K, O'Meara S, Teague JW, Butler AP, Cazzaniga G, Biondi A, Zuna J, Kempski H, Muschen M, Ford AM, Stratton MR, Greaves M, Campbell PJ. PMID: 24413735; PMCID: PMC3960636.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansCells
    152. Heterogeneity of genomic evolution and mutational profiles in multiple myeloma. Nat Commun. 2014; 5:2997. Bolli N, Avet-Loiseau H, Wedge DC, Van Loo P, Alexandrov LB, Martincorena I, Dawson KJ, Iorio F, Nik-Zainal S, Bignell GR, Hinton JW, Li Y, Tubio JM, McLaren S, O' Meara S, Butler AP, Teague JW, Mudie L, Anderson E, Rashid N, Tai YT, Shammas MA, Sperling AS, Fulciniti M, Richardson PG, Parmigiani G, Magrangeas F, Minvielle S, Moreau P, Attal M, Facon T, Futreal PA, Anderson KC, Campbell PJ, Munshi NC. PMID: 24429703; PMCID: PMC3905727.
      View in: PubMed   Mentions: 490     Fields:    Translation:Humans
    153. Mutational signatures: the patterns of somatic mutations hidden in cancer genomes. Curr Opin Genet Dev. 2014 Feb; 24:52-60. Alexandrov LB, Stratton MR. PMID: 24657537; PMCID: PMC3990474.
      View in: PubMed   Mentions: 228     Fields:    Translation:Humans
    154. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet. 2014 Jan; 46(1):33-8. Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, Tiffen JC, Kober C, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium, Green AR, Massie CE, Nangalia J, Lempidaki S, Döhner H, Döhner K, Bray SJ, McDermott U, Papaemmanuil E, Campbell PJ, Adams DJ. PMID: 24316979; PMCID: PMC3874239.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    155. Signatures of mutational processes in human cancer. Nature. 2013 Aug 22; 500(7463):415-21. Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjörd JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinski M, Imielinsk M, Jäger N, Jones DT, Jones D, Knappskog S, Kool M, Lakhani SR, López-Otín C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K, Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt AN, Valdés-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR. PMID: 23945592; PMCID: PMC3776390.
      View in: PubMed   Mentions: 4751     Fields:    Translation:HumansCells
    156. Specificity and heterogeneity of terahertz radiation effect on gene expression in mouse mesenchymal stem cells. Sci Rep. 2013; 3:1184. Alexandrov BS, Phipps ML, Alexandrov LB, Booshehri LG, Erat A, Zabolotny J, Mielke CH, Chen HT, Rodriguez G, Rasmussen KØ, Martinez JS, Bishop AR, Usheva A. PMID: 23378916; PMCID: PMC3560359.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    157. Binding of nucleoid-associated protein fis to DNA is regulated by DNA breathing dynamics. PLoS Comput Biol. 2013; 9(1):e1002881. Nowak-Lovato K, Alexandrov LB, Banisadr A, Bauer AL, Bishop AR, Usheva A, Mu F, Hong-Geller E, Rasmussen KØ, Hlavacek WS, Alexandrov BS. PMID: 23341768; PMCID: PMC3547798.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    158. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 2013 Jan 31; 3(1):246-59. Alexandrov LB, Nik-Zainal S, Wedge DC, Campbell PJ, Stratton MR. PMID: 23318258; PMCID: PMC3588146.
      View in: PubMed   Mentions: 618     Fields:    Translation:HumansCells
    159. Mutational processes molding the genomes of 21 breast cancers. Cell. 2012 May 25; 149(5):979-93. Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, Jones D, Hinton J, Marshall J, Stebbings LA, Menzies A, Martin S, Leung K, Chen L, Leroy C, Ramakrishna M, Rance R, Lau KW, Mudie LJ, Varela I, McBride DJ, Bignell GR, Cooke SL, Shlien A, Gamble J, Whitmore I, Maddison M, Tarpey PS, Davies HR, Papaemmanuil E, Stephens PJ, McLaren S, Butler AP, Teague JW, Jönsson G, Garber JE, Silver D, Miron P, Fatima A, Boyault S, Langerød A, Tutt A, Martens JW, Aparicio SA, Borg Å, Salomon AV, Thomas G, Børresen-Dale AL, Richardson AL, Neuberger MS, Futreal PA, Campbell PJ, Stratton MR, Breast Cancer Working Group of the International Cancer Genome Consortium. PMID: 22608084; PMCID: PMC3414841.
      View in: PubMed   Mentions: 1023     Fields:    Translation:Humans
    160. The life history of 21 breast cancers. Cell. 2012 May 25; 149(5):994-1007. Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD, Lau KW, Raine K, Jones D, Marshall J, Ramakrishna M, Shlien A, Cooke SL, Hinton J, Menzies A, Stebbings LA, Leroy C, Jia M, Rance R, Mudie LJ, Gamble SJ, Stephens PJ, McLaren S, Tarpey PS, Papaemmanuil E, Davies HR, Varela I, McBride DJ, Bignell GR, Leung K, Butler AP, Teague JW, Martin S, Jönsson G, Mariani O, Boyault S, Miron P, Fatima A, Langerød A, Aparicio SA, Tutt A, Sieuwerts AM, Borg Å, Thomas G, Salomon AV, Richardson AL, Børresen-Dale AL, Futreal PA, Stratton MR, Campbell PJ, Breast Cancer Working Group of the International Cancer Genome Consortium. PMID: 22608083; PMCID: PMC3428864.
      View in: PubMed   Mentions: 739     Fields:    Translation:Humans
    161. Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer. Cell. 2012 Feb 17; 148(4):780-91. Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ, Fu B, Hims M, Ding Z, Ivakhno S, Stewart C, Ng BL, Wong W, Aken B, White S, Alsop A, Becq J, Bignell GR, Cheetham RK, Cheng W, Connor TR, Cox AJ, Feng ZP, Gu Y, Grocock RJ, Harris SR, Khrebtukova I, Kingsbury Z, Kowarsky M, Kreiss A, Luo S, Marshall J, McBride DJ, Murray L, Pearse AM, Raine K, Rasolonjatovo I, Shaw R, Tedder P, Tregidgo C, Vilella AJ, Wedge DC, Woods GM, Gormley N, Humphray S, Schroth G, Smith G, Hall K, Searle SM, Carter NP, Papenfuss AT, Futreal PA, Campbell PJ, Yang F, Bentley DR, Evers DJ, Stratton MR. PMID: 22341448; PMCID: PMC3281993.
      View in: PubMed   Mentions: 157     Fields:    Translation:Animals
    162. Non-thermal effects of terahertz radiation on gene expression in mouse stem cells. Biomed Opt Express. 2011 Sep 01; 2(9):2679-89. Alexandrov BS, Rasmussen KØ, Bishop AR, Usheva A, Alexandrov LB, Chong S, Dagon Y, Booshehri LG, Mielke CH, Phipps ML, Martinez JS, Chen HT, Rodriguez G. PMID: 21991556; PMCID: PMC3184876.
      View in: PubMed   Mentions: 29  
    163. DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases. PLoS One. 2011; 6(5):e19800. Alexandrov BS, Valtchinov VI, Alexandrov LB, Gelev V, Dagon Y, Bock J, Kohane IS, Rasmussen KØ, Bishop AR, Usheva A. PMID: 21625483; PMCID: PMC3098838.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    164. Mammalian stem cells reprogramming in response to terahertz radiation. PLoS One. 2010 Dec 31; 5(12):e15806. Bock J, Fukuyo Y, Kang S, Phipps ML, Alexandrov LB, Rasmussen KØ, Bishop AR, Rosen ED, Martinez JS, Chen HT, Rodriguez G, Alexandrov BS, Usheva A. PMID: 21209821; PMCID: PMC3013123.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    165. DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation. Nucleic Acids Res. 2010 Apr; 38(6):1790-5. Alexandrov BS, Gelev V, Yoo SW, Alexandrov LB, Fukuyo Y, Bishop AR, Rasmussen KØ, Usheva A. PMID: 20019064; PMCID: PMC2847213.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    166. Computer modeling describes gravity-related adaptation in cell cultures. PLoS One. 2009 Dec 16; 4(12):e8332. Alexandrov LB, Alexandrova S, Usheva A. PMID: 20016778; PMCID: PMC2790613.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    167. A nonlinear dynamic model of DNA with a sequence-dependent stacking term. Nucleic Acids Res. 2009 Apr; 37(7):2405-10. Alexandrov BS, Gelev V, Monisova Y, Alexandrov LB, Bishop AR, Rasmussen KØ, Usheva A. PMID: 19264801; PMCID: PMC2673413.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    168. Modelling the magnetic signature of neuronal tissue. Neuroimage. 2007 Aug 01; 37(1):137-48. Blagoev KB, Mihaila B, Travis BJ, Alexandrov LB, Bishop AR, Ranken D, Posse S, Gasparovic C, Mayer A, Aine CJ, Ulbert I, Morita M, Müller W, Connor J, Halgren E. PMID: 17544300.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
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