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Alan Hofmann

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
    NIH R03DK064891Aug 15, 2004 - Jul 31, 2008
    Role: Principal Investigator
    MODELING OF THE ENTEROHEPATHIC CIRCULATION OF BILE ACIDS
    NIH F06TW001036Aug 22, 1986
    Role: Principal Investigator
    BILE ACID METABOLISM IN HEALTH AND DISEASE
    NIH R01DK021506Apr 1, 1978 - Oct 31, 1998
    Role: Principal Investigator
    BILE ACID METABOLISM IN HEALTH AND DISEASE
    NIH R01AM021506Apr 1, 1978 - Mar 31, 1988
    Role: Principal Investigator
    Training Grant in Gastroenterology
    NIH T32DK007202Jul 1, 1976 - Jun 30, 2023
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Reply to: "Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion". J Hepatol. 2021 Feb 20. Keiding S, Frisch K, Hofmann AF. PMID: 33621633.
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    2. Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis. J Hepatol. 2021 Jan; 74(1):58-65. Kjærgaard K, Frisch K, Sørensen M, Munk OL, Hofmann AF, Horsager J, Schacht AC, Erickson M, Shapiro D, Keiding S. PMID: 32717289.
      View in: PubMed   Mentions:    Fields:    
    3. Quantifying the Complexities of Bile Acid Metabolism in Man: Continued Progress. Cell Mol Gastroenterol Hepatol. 2020; 10(1):201-202. Hofmann AF. PMID: 32240639.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Causal Role of Bile Acids in Irritable Bowel Syndrome-Constipation. Clin Gastroenterol Hepatol. 2019 01; 17(1):213-214. Hofmann AF. PMID: 30558894.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther. 2019 01; 49(2):183-193. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R. PMID: 30506692.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    6. Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood. Hepatology. 2019 02; 69(2):666-683. Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R. PMID: 30102412.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    7. Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease. Physiol Rev. 2018 10 01; 98(4):1983-2023. Hegyi P, Maléth J, Walters JR, Hofmann AF, Keely SJ. PMID: 30067158.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    8. Absorption of Unconjugated Bile Acids from the Perfused Jejunum of the Anesthetized Rat: Structure-Activity Relationships and Rate-Limiting Steps. Lipids. 2018 05; 53(5):465-468. Dupas JL, Ho NFH, Hofmann AF. PMID: 30071138.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Plasma Bile Acid Concentrations in Humans: Suggestions for Presentation in Tabular Form. Hepatology. 2018 08; 68(2):787. Hofmann AF, Marschall HU. PMID: 29604219.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Bile Acids and the Microbiome in the Cow: Lack of Deoxycholic Acid Hydroxylation. Lipids. 2018 03; 53(3):269-270. Hofmann AF, Herdt T, Ames NK, Chen Z, Hagey LR. PMID: 29668048.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Chemical Synthesis of Rare Natural Bile Acids: 11a-Hydroxy Derivatives of Lithocholic and Chenodeoxycholic Acids. Lipids. 2018 04; 53(4):403-411. Namegawa K, Iida K, Omura K, Ogawa S, Hofmann AF, Iida T. PMID: 29520792.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. Bile Acid Replacement in Bile Acid Synthesis Defects. J Pediatr Gastroenterol Nutr. 2017 12; 65(6):e134. Hofmann AF. PMID: 28800025.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Two Inborn Errors of Bile Acid Biosynthesis: The Need for Recognition and Treatment by Primary Bile Acid Replacement. J Pediatr Gastroenterol Nutr. 2017 06; 64(6):849-850. Hofmann AF. PMID: 28333767.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Seventy Years of Polyethylene Glycols in Gastroenterology: The Journey of PEG 4000 and 3350 From Nonabsorbable Marker to Colonoscopy Preparation to Osmotic Laxative. Gastroenterology. 2017 03; 152(4):675-680. Fordtran JS, Hofmann AF. PMID: 28147222.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Chemical Synthesis of Uncommon Natural Bile Acids: The 9a-Hydroxy Derivatives of Chenodeoxycholic and Lithocholic Acids. Chem Pharm Bull (Tokyo). 2016 Sep 01; 64(9):1397-402. Iida T, Namegawa K, Nakane N, Iida K, Hofmann AF, Omura K. PMID: 27319285.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Let the Bile Flow! 1.0. Hepatology. 2016 10; 64(4):1387-8. Hofmann AF. PMID: 27178666.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Two Major Bile Acids in the Hornbills, (24R,25S)-3a,7a,24-Trihydroxy-5ß-cholestan-27-oyl Taurine and Its 12a-Hydroxy Derivative. Lipids. 2016 06; 51(6):757-68. Satoh R, Ogata H, Saito T, Zhou B, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Hagey LR, Hofmann AF, Iida T. PMID: 27108034.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Hepatobiliary Secretion Kinetics of Conjugated Bile Acids Measured in Pigs by 11C-Cholylsarcosine PET. J Nucl Med. 2016 06; 57(6):961-6. Sørensen M, Munk OL, Ørntoft NW, Frisch K, Andersen KJ, Mortensen FV, Alstrup AK, Ott P, Hofmann AF, Keiding S. PMID: 26966160.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    19. Novel, major 2a- and 2ß-hydroxy bile alcohols and bile acids in the bile of Arapaima gigas, a large South American river fish. Steroids. 2016 Mar; 107:112-20. Sato née Okihara R, Saito T, Ogata H, Nakane N, Namegawa K, Sekiguchi S, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Raines J, Hagey LR, Hofmann AF, Iida T. PMID: 26768415.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    20. Focused metabolomics using liquid chromatography/electrospray ionization tandem mass spectrometry for analysis of urinary conjugated cholesterol metabolites from patients with Niemann-Pick disease type C and 3ß-hydroxysteroid dehydrogenase deficiency. Ann Clin Biochem. 2015 Sep; 52(Pt 5):576-87. Maekawa M, Shimada M, Ohno K, Togawa M, Nittono H, Iida T, Hofmann AF, Goto J, Yamaguchi H, Mano N. PMID: 25575700.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Gastrolithiasis in prehensile-tailed porcupines (Coendou prehensilis): nine cases and pathogenesis of stone formation. J Zoo Wildl Med. 2014 Dec; 45(4):883-91. Spriggs M, Thompson KA, Barton D, Talley J, Volle K, Stasiak I, Beyea L, Guthrie A, Roda A, Camborata C, Hofmann AF, Hagey LR. PMID: 25632677.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Improved chemical synthesis, X-ray crystallographic analysis, and NMR characterization of (22R)-/(22S)-hydroxy epimers of bile acids. Lipids. 2014 Nov; 49(11):1169-80. Omura K, Ohsaki A, Zhou B, Kushida M, Mitsuma T, Kobayashi A, Hagey LR, Hofmann AF, Iida T. PMID: 25319478.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3297-305. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T. PMID: 25074909.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    24. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res. 2014 Aug; 55(8):1553-95. Hofmann AF, Hagey LR. PMID: 24838141.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    25. A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS. J Lipid Res. 2014 May; 55(5):978-90. Kakiyama G, Muto A, Takei H, Nittono H, Murai T, Kurosawa T, Hofmann AF, Pandak WM, Bajaj JS. PMID: 24627129.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    26. Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids. J Hepatol. 2014 Jun; 60(6):1259-67. Wang L, Hartmann P, Haimerl M, Bathena SP, Sjöwall C, Almer S, Alnouti Y, Hofmann AF, Schnabl B. PMID: 24560660.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. The bile acid TGR5 membrane receptor: from basic research to clinical application. Dig Liver Dis. 2014 Apr; 46(4):302-12. Duboc H, Taché Y, Hofmann AF. PMID: 24411485.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    28. N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish. Steroids. 2014 Feb; 80:15-23. Satoh Née Okihara R, Saito T, Ogata H, Ohsaki A, Iida T, Asahina K, Mitamura K, Ikegawa S, Hofmann AF, Hagey LR. PMID: 24291417.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15; 305(4):G286-94. Wang R, Liu L, Sheps JA, Forrest D, Hofmann AF, Hagey LR, Ling V. PMID: 23764895.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    30. LC/ESI-MS/MS analysis of urinary 3ß-sulfooxy-7ß-N-acetylglucosaminyl-5-cholen-24-oic acid and its amides: new biomarkers for the detection of Niemann-Pick type C disease. Steroids. 2013 Oct; 78(10):967-72. Maekawa M, Misawa Y, Sotoura A, Yamaguchi H, Togawa M, Ohno K, Nittono H, Kakiyama G, Iida T, Hofmann AF, Goto J, Shimada M, Mano N. PMID: 23751200.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    31. An efficient synthesis of 7a,12a-dihydroxy-4-cholesten-3-one and its biological precursor 7a-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis. Steroids. 2013 Sep; 78(9):927-37. Ogawa S, Zhou B, Kimoto Y, Omura K, Kobayashi A, Higashi T, Mitamura K, Ikegawa S, Hagey LR, Hofmann AF, Iida T. PMID: 23707572.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    32. Ursodeoxycholic acid attenuates colonic epithelial secretory function. J Physiol. 2013 May 01; 591(9):2307-18. Kelly OB, Mroz MS, Ward JB, Colliva C, Scharl M, Pellicciari R, Gilmer JF, Fallon PG, Hofmann AF, Roda A, Murray FE, Keely SJ. PMID: 23507881.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Gastroenterology. 2013 May; 144(5):945-955.e6; quiz e14-5. Setchell KD, Heubi JE, Shah S, Lavine JE, Suskind D, Al-Edreesi M, Potter C, Russell DW, O'Connell NC, Wolfe B, Jha P, Zhang W, Bove KE, Knisely AS, Hofmann AF, Rosenthal P, Bull LN. PMID: 23415802.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    34. A novel varanic acid epimer--(24R,25S)-3a,7a,12a,24-tetrahydroxy-5ß-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster. Steroids. 2012 Nov; 77(13):1510-21. Hagey LR, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann AF, Iida T. PMID: 22986074.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    35. Synthesis of multiply deuterated 3- and 21-monosulfates of allo-tetrahydrocorticosteroids as internal standards for mass spectrometry. Steroids. 2012 Nov; 77(13):1423-37. Mitamura K, Mabuchi T, Nagae K, Nakajima M, Matsumoto R, Fujioka S, Sato K, Satoh née Okihara R, Iida T, Ogawa S, Hofmann AF, Ikegawa S. PMID: 22960650.
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    36. Detection of ?4-3-oxo-steroid 5ß-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 01; 900:24-31. Muto A, Takei H, Unno A, Murai T, Kurosawa T, Ogawa S, Iida T, Ikegawa S, Mori J, Ohtake A, Hoshina T, Mizuochi T, Kimura A, Hofmann AF, Hagey LR, Nittono H. PMID: 22695323.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    37. [N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs. J Nucl Med. 2012 May; 53(5):772-8. Frisch K, Jakobsen S, Sørensen M, Munk OL, Alstrup AK, Ott P, Hofmann AF, Keiding S. PMID: 22454486.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    38. Synthesis of the 3-sulfates of S-acyl glutathione conjugated bile acids and their biotransformation by a rat liver cytosolic fraction. Chem Phys Lipids. 2012 Apr; 165(3):261-9. Mitamura K, Hori N, Mino S, Iida T, Hofmann AF, Ikegawa S. PMID: 22343050.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    39. Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS. Steroids. 2011 Dec 20; 76(14):1609-14. Mitamura K, Hori N, Iida T, Suzuki M, Shimizu T, Nittono H, Takaori K, Takikawa H, Hofmann AF, Ikegawa S. PMID: 22019844.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    40. Herbert Falk: a vital force in the renaissance of bile acid research and bile acid therapy. Dig Dis. 2011; 29(1):23-36. Hofmann AF. PMID: 21691101.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3a,7a,24-trihydroxy-5ß-cholestan-27-oic acid and two epimers (25R and 25S) of 3a,7a-dihydroxy-5ß-cholestan-27-oic acid. Steroids. 2011 Sep-Oct; 76(10-11):1126-35. Hagey LR, Iida T, Ogawa S, Adachi Y, Une M, Mushiake K, Maekawa M, Shimada M, Mano N, Hofmann AF. PMID: 21600907.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Chemical synthesis of the (25R)- and (25S)-epimers of 3a,7a,12a-trihydroxy-5a-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates. Chem Phys Lipids. 2011 Jul; 164(5):368-77. Ogawa S, Mitamura K, Ikegawa S, Krasowski MD, Hagey LR, Hofmann AF, Iida T. PMID: 21554864.
      View in: PubMed   Mentions: 2     Fields:    
    43. Characterization of non-enzymatic acylation of amino or thiol groups of bionucleophiles by the acyl-adenylate or acyl-CoA thioester of cholic acid. Anal Bioanal Chem. 2011 Jun; 400(7):2253-9. Mitamura K, Aoyama E, Sakai T, Iida T, Hofmann AF, Ikegawa S. PMID: 21491109.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    44. Synthesis of the 3-sulfates of N-acetylcysteine conjugated bile acids (BA-NACs) and their transient formation from BA-NACs and subsequent hydrolysis by a rat liver cytosolic fraction as shown by liquid chromatography/electrospray ionization-mass spectrometry. Anal Bioanal Chem. 2011 Jun; 400(7):2061-72. Mitamura K, Sakai T, Nakai R, Wakamiya T, Iida T, Hofmann AF, Ikegawa S. PMID: 21455648.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    45. Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release. Hepatology. 2011 May; 53(5):1784. Hofmann AF. PMID: 21520190.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    46. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology. 2010 Nov; 52(5):1758-68. Denk GU, Maitz S, Wimmer R, Rust C, Invernizzi P, Ferdinandusse S, Kulik W, Fuchsbichler A, Fickert P, Trauner M, Hofmann AF, Beuers U. PMID: 21038414.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    47. COMPLEX EVOLUTION OF BILE SALTS IN BIRDS. . 2010 Oct; 127(4):820-831. Hagey LR, Vidal N, Hofmann AF, Krasowski MD. PMID: 21113274.
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    48. Identification of bile acid S-acyl glutathione conjugates in rat bile by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry. Steroids. 2011 Jan; 76(1-2):68-77. Mitamura K, Hori N, Iida T, Hofmann AF, Ikegawa S. PMID: 20837038.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Hepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters. Drug Metab Dispos. 2010 Oct; 38(10):1723-30. Megaraj V, Iida T, Jungsuwadee P, Hofmann AF, Vore M. PMID: 20643783.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. Zoolog Sci. 2010 Jul; 27(7):565-73. Hagey LR, Lida T, Tamegai H, Ogawa S, Une M, Asahina K, Mushiake K, Goto T, Mano N, Goto J, Krasowski MD, Hofmann AF. PMID: 20608845.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    51. Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. BMC Evol Biol. 2010 May 06; 10:133. Hagey LR, Vidal N, Hofmann AF, Krasowski MD. PMID: 20444292.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    52. Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. Physiol Biochem Zool. 2010 Mar-Apr; 83(2):308-21. Hagey LR, Møller PR, Hofmann AF, Krasowski MD. PMID: 20113173.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    53. Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last. Expert Rev Gastroenterol Hepatol. 2009 Oct; 3(5):461-4. Hofmann AF. PMID: 19817666.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    54. Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Clin Gastroenterol Hepatol. 2009 Nov; 7(11):1151-4. Hofmann AF, Mangelsdorf DJ, Kliewer SA. PMID: 19665580.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    55. Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res. 2010 Feb; 51(2):226-46. Hofmann AF, Hagey LR, Krasowski MD. PMID: 19638645.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    56. Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells. J Cell Mol Med. 2009 Aug; 13(8B):2293-303. Keating N, Mroz MS, Scharl MM, Marsh C, Ferguson G, Hofmann AF, Keely SJ. PMID: 19583809.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    57. Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice. Hepatology. 2009 Jun; 49(6):1972-81. Halilbasic E, Fiorotto R, Fickert P, Marschall HU, Moustafa T, Spirli C, Fuchsbichler A, Gumhold J, Silbert D, Zatloukal K, Langner C, Maitra U, Denk H, Hofmann AF, Strazzabosco M, Trauner M. PMID: 19475687.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    58. Bile acids: trying to understand their chemistry and biology with the hope of helping patients. Hepatology. 2009 May; 49(5):1403-18. Hofmann AF. PMID: 19296471.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    59. Chemical synthesis of 3beta-sulfooxy-7beta-hydroxy-24-nor-5-cholenoic acid: an internal standard for mass spectrometric analysis of the abnormal delta5-bile acids occurring in Niemann-Pick disease. Steroids. 2009 Sep; 74(9):766-72. Kakiyama G, Muto A, Shimada M, Mano N, Goto J, Hofmann AF, Iida T. PMID: 19394355.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    60. Chemical synthesis of bile acid acyl-adenylates and formation by a rat liver microsomal fraction. Steroids. 2009 Sep; 74(9):751-7. Ikegawa S, Ito H, Ohshima M, Maeda M, Hofmann AF, Mitamura K. PMID: 19376146.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    61. Chemical synthesis of N-acetylcysteine conjugates of bile acids and in vivo formation in cholestatic rats as shown by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 01; 877(25):2630-8. Mitamura K, Watanabe S, Sakai T, Okihara R, Sogabe M, Wakamiya T, Hofmann AF, Ikegawa S. PMID: 19346170.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    62. Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. Pancreas. 2009 Mar; 38(2):232-3. Money ME, Hofmann AF, Hagey LR, Walkowiak J, Talley NJ. PMID: 19238028.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    63. In memoriam: Dr. Herbert Falk (1924-2008). Hepatology. 2009 Jan; 49(1):1-3. Hofmann AF. PMID: 19108004.
      View in: PubMed   Mentions: 2     Fields:    
    64. The enterohepatic circulation of bile acids in mammals: form and functions. Front Biosci (Landmark Ed). 2009 Jan 01; 14:2584-98. Hofmann AF. PMID: 19273221.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    65. A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid. J Lipid Res. 2009 Apr; 50(4):651-7. Hagey LR, Kakiyama G, Muto A, Iida T, Mushiake K, Goto T, Mano N, Goto J, Oliveira CA, Hofmann AF. PMID: 19011113.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    66. Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):598-606. Hofmann AF, Loening-Baucke V, Lavine JE, Hagey LR, Steinbach JH, Packard CA, Griffin TL, Chatfield DA. PMID: 18955863.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    67. A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane. Steroids. 2009 Jan; 74(1):81-7. Ogawa S, Kakiyama G, Muto A, Hosoda A, Mitamura K, Ikegawa S, Hofmann AF, Iida T. PMID: 18996406.
      View in: PubMed   Mentions: 3     Fields:    
    68. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci. 2008 Aug; 65(16):2461-83. Hofmann AF, Hagey LR. PMID: 18488143.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimals
    69. Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2008 Jul; 295(1):G54-G62. Monte MJ, Rosales R, Macias RI, Iannota V, Martinez-Fernandez A, Romero MR, Hofmann AF, Marin JJ. PMID: 18467501.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    70. Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res. 2008 Jul; 49(7):1577-87. Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann AF, Krasowski MD. PMID: 18362391.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    71. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27; 51(6):1831-41. Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J. PMID: 18307294.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    72. Production and characterization of a monoclonal antibody to capture proteins tagged with lithocholic acid. Anal Sci. 2008; 24(11):1475-80. Ikegawa S, Yamamoto T, Miyashita T, Okihara R, Ishiwata S, Sakai T, Chong RH, Maeda M, Hofmann AF, Mitamura K. PMID: 18997378.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    73. Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid. J Lipid Res. 2007 Dec; 48(12):2682-92. Kakiyama G, Tamegai H, Iida T, Mitamura K, Ikegawa S, Goto T, Mano N, Goto J, Holz P, Hagey LR, Hofmann AF. PMID: 17785716.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    74. Enhancement of dietary protein digestion by conjugated bile acids. Gastroenterology. 2007 Jul; 133(1):16-23. Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. PMID: 17631126.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    75. Human cecal bile acids: concentration and spectrum. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G256-63. Hamilton JP, Xie G, Raufman JP, Hogan S, Griffin TL, Packard CA, Chatfield DA, Hagey LR, Steinbach JH, Hofmann AF. PMID: 17412828.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    76. Why bile acid glucuronidation is a minor pathway for conjugation of endogenous bile acids in man. Hepatology. 2007 Apr; 45(4):1083-4; author reply 1084-5. Hofmann AF. PMID: 17393523.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    77. Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system. J Org Chem. 2007 Feb 02; 72(3):823-30. Iida T, Ogawa S, Hosoi K, Makino M, Fujimoto Y, Goto T, Mano N, Goto J, Hofmann AF. PMID: 17253801.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    78. Biliary secretion and excretion in health and disease: current concepts. Ann Hepatol. 2007 Jan-Mar; 6(1):15-27. Hofmann AF. PMID: 17297425.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    79. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G290-7. Keely SJ, Scharl MM, Bertelsen LS, Hagey LR, Barrett KE, Hofmann AF. PMID: 16901996.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    80. Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology. 2006 Jul; 44(1):195-204. Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP. PMID: 16799980.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    81. Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. J Lipid Res. 2006 Sep; 47(9):2020-7. Sehayek E, Hagey LR, Fung YY, Duncan EM, Yu HJ, Eggertsen G, Björkhem I, Hofmann AF, Breslow JL. PMID: 16763287.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    82. Nasobiliary drainage for cholestatic pruritus. Hepatology. 2006 May; 43(5):1170-1. Hofmann AF, Huet PM. PMID: 16628631.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    83. Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid. J Lipid Res. 2006 Jul; 47(7):1551-8. Kakiyama G, Iida T, Goto T, Mano N, Goto J, Nambara T, Hagey LR, Schteingart CD, Hofmann AF. PMID: 16648547.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    84. How bile acids confer gut mucosal protection against bacteria. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4333-4. Hofmann AF, Eckmann L. PMID: 16537368.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    85. Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G550-6. Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, Sugiyama Y. PMID: 16474011.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    86. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb; 130(2):465-81. Fickert P, Wagner M, Marschall HU, Fuchsbichler A, Zollner G, Tsybrovskyy O, Zatloukal K, Liu J, Waalkes MP, Cover C, Denk H, Hofmann AF, Jaeschke H, Trauner M. PMID: 16472600.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals
    87. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology. 2005 Dec; 42(6):1391-8. Hofmann AF, Zakko SF, Lira M, Clerici C, Hagey LR, Lambert KK, Steinbach JH, Schteingart CD, Olinga P, Groothuis GM. PMID: 16317695.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    88. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim Biophys Acta. 2005 Dec 30; 1738(1-3):54-62. Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF, Sugiyama Y. PMID: 16332456.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    89. Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G640-9. Rius M, Hummel-Eisenbeiss J, Hofmann AF, Keppler D. PMID: 16282361.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    90. Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis. Hepatology. 2005 Nov; 42(5):1184-93. Combes B, Emerson SS, Flye NL, Munoz SJ, Luketic VA, Mayo MJ, McCashland TM, Zetterman RK, Peters MG, Di Bisceglie AM, Benner KG, Kowdley KV, Carithers RL, Rosoff L, Garcia-Tsao G, Boyer JL, Boyer TD, Martinez EJ, Bass NM, Lake JR, Barnes DS, Bonacini M, Lindsay KL, Mills AS, Markin RS, Rubin R, West AB, Wheeler DE, Contos MJ, Hofmann AF. PMID: 16250039.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    91. Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3beta,7beta-dihydroxy-5-cholen-24-oic acid, and related compounds: unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1. Steroids. 2006 Jan; 71(1):18-29. Iida T, Kakiyama G, Hibiya Y, Miyata S, Inoue T, Ohno K, Goto T, Mano N, Goto J, Nambara T, Hofmann AF. PMID: 16197972.
      View in: PubMed   Mentions: 10     Fields:    
    92. A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res. 2005 Oct; 46(10):2221-32. Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann AF. PMID: 16061950.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    93. Increased deoxycholic acid absorption and gall stones in acromegalic patients treated with octreotide: more evidence for a connection between slow transit constipation and gall stones. Gut. 2005 May; 54(5):575-8. Hofmann AF. PMID: 15831896.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    94. Helicobacter and cholesterol gallstones: do findings in the mouse apply to man? Gastroenterology. 2005 Apr; 128(4):1126-9. Hofmann AF. PMID: 15825095.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    95. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev. 2004 Oct; 36(3-4):703-22. Hofmann AF. PMID: 15554243.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    96. Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G159-67. Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y. PMID: 15297262.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    97. Gallstone disease: physicochemical research sheds new light on an old disease and points the way to medical therapy. J Hepatol. 2004 Aug; 41(2):195-200. Hofmann AF. PMID: 15288466.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    98. Douglas B. McGill, 1929-2004. Gastroenterology. 2004 Jun; 126(7):1890-2. Hofmann AF. PMID: 15188184.
      View in: PubMed   Mentions:    Fields:    
    99. Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat. J Lipid Res. 2004 Mar; 45(3):567-73. Kakiyama G, Iida T, Yoshimoto A, Goto T, Mano N, Goto J, Nambara T, Hagey LR, Hofmann AF. PMID: 14657194.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    100. Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry. Gut. 2003 Sep; 52(9):1239-41. Hofmann AF. PMID: 12912852.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    101. Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med. 2003 Jun; 141(6):411-8. Porter JL, Fordtran JS, Santa Ana CA, Emmett M, Hagey LR, Macdonald EA, Hofmann AF. PMID: 12819639.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    102. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology. 2003 Mar; 37(3):551-7. Lorenzo-Zúñiga V, Bartolí R, Planas R, Hofmann AF, Viñado B, Hagey LR, Hernández JM, Mañé J, Alvarez MA, Ausina V, Gassull MA. PMID: 12601352.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    103. The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease. Liver Int. 2003; 23 Suppl 3:34-8. Zeh N, Rossi SS, Hofmann AF, Steinbach JH, Hagey LR, Oliver D, Stange J, Hassanein T. PMID: 12950959.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    104. Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids. Chem Pharm Bull (Tokyo). 2002 Oct; 50(10):1327-34. Iida T, Hikosaka M, Kakiyama G, Shiraishi K, Schteingart CD, Hagey LR, Ton-Nu HT, Hofmann AF, Mano N, Goto J, Nambara T. PMID: 12372858.
      View in: PubMed   Mentions: 6     Fields:    
    105. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology. 2002 May; 35(5):1031-40. Meng LJ, Wang P, Wolkoff AW, Kim RB, Tirona RG, Hofmann AF, Pang KS. PMID: 11981753.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    106. Cholestatic liver disease: pathophysiology and therapeutic options. Liver. 2002; 22 Suppl 2:14-9. Hofmann AF. PMID: 12220297.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    107. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med. 1999 Dec 13-27; 159(22):2647-58. Hofmann AF. PMID: 10597755.
      View in: PubMed   Mentions: 174     Fields:    Translation:Humans
    108. Bile Acids: The Good, the Bad, and the Ugly. News Physiol Sci. 1999 Feb; 14:24-29. Hofmann AF. PMID: 11390813.
      View in: PubMed   Mentions: 85     Fields:    
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