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    Alan Hofmann

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0063
    CA La Jolla 92093
    Phone858-822-3811
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      DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
      NIH/NIDDK R03DK064891Aug 15, 2004 - Jul 31, 2008
      Role: Principal Investigator
      MODELING OF THE ENTEROHEPATHIC CIRCULATION OF BILE ACIDS
      NIH/FIC F06TW001036Aug 22, 1986
      Role: Principal Investigator
      BILE ACID METABOLISM IN HEALTH AND DISEASE
      NIH/NIDDK R01DK021506Apr 1, 1978 - Oct 31, 1998
      Role: Principal Investigator
      BILE ACID METABOLISM IN HEALTH AND DISEASE
      NIH/NIADDK R01AM021506Apr 1, 1978 - Mar 31, 1988
      Role: Principal Investigator
      GASTROENTEROLOGY TRAINING GRANT
      NIH/NIDDK T32DK007202Jul 1, 1976 - Jun 30, 2017
      Role: Co-Principal Investigator

      Collapse ORNG Applications 
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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hofmann A. Response to Letter to the Editor: Bile Acid Replacement in Bile Acid Synthesis Defects. J Pediatr Gastroenterol Nutr. 2017 Aug 09. PMID: 28800025.
        View in: PubMed
      2. Hofmann A. Let the Bile Flow! 1.0. Hepatology. 2016 Oct; 64(4):1387-8. PMID: 27178666.
        View in: PubMed
      3. Satoh R, Ogata H, Saito T, Zhou B, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Hagey LR, Hofmann A, Iida T. Two Major Bile Acids in the Hornbills, (24R,25S)-3a,7a,24-Trihydroxy-5ß-cholestan-27-oyl Taurine and Its 12a-Hydroxy Derivative. Lipids. 2016 Jun; 51(6):757-68. PMID: 27108034.
        View in: PubMed
      4. Sato née Okihara R, Saito T, Ogata H, Nakane N, Namegawa K, Sekiguchi S, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Raines J, Hagey LR, Hofmann A, Iida T. Novel, major 2a- and 2ß-hydroxy bile alcohols and bile acids in the bile of Arapaima gigas, a large South American river fish. Steroids. 2016 Mar; 107:112-20. PMID: 26768415.
        View in: PubMed
      5. Spriggs M, Thompson KA, Barton D, Talley J, Volle K, Stasiak I, Beyea L, Guthrie A, Roda A, Camborata C, Hofmann A, Hagey LR. Gastrolithiasis in prehensile-tailed porcupines (Coendou prehensilis): nine cases and pathogenesis of stone formation. J Zoo Wildl Med. 2014 Dec; 45(4):883-91. PMID: 25632677.
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      6. Omura K, Ohsaki A, Zhou B, Kushida M, Mitsuma T, Kobayashi A, Hagey LR, Hofmann A, Iida T. Improved chemical synthesis, X-ray crystallographic analysis, and NMR characterization of (22R)-/(22S)-hydroxy epimers of bile acids. Lipids. 2014 Nov; 49(11):1169-80. PMID: 25319478.
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      7. Hofmann A, Hagey LR. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res. 2014 Aug; 55(8):1553-95. PMID: 24838141; PMCID: PMC4109754.
      8. Kakiyama G, Muto A, Takei H, Nittono H, Murai T, Kurosawa T, Hofmann A, Pandak WM, Bajaj JS. A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS. J Lipid Res. 2014 May; 55(5):978-90. PMID: 24627129; PMCID: PMC3995475.
      9. Wang L, Hartmann P, Haimerl M, Bathena SP, Sjöwall C, Almer S, Alnouti Y, Hofmann A, Schnabl B. Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids. J Hepatol. 2014 Jun; 60(6):1259-67. PMID: 24560660; PMCID: PMC4028388.
      10. Duboc H, Taché Y, Hofmann A. The bile acid TGR5 membrane receptor: from basic research to clinical application. Dig Liver Dis. 2014 Apr; 46(4):302-12. PMID: 24411485.
        View in: PubMed
      11. Satoh Née Okihara R, Saito T, Ogata H, Ohsaki A, Iida T, Asahina K, Mitamura K, Ikegawa S, Hofmann A, Hagey LR. N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish. Steroids. 2014 Feb; 80:15-23. PMID: 24291417.
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      12. Wang R, Liu L, Sheps JA, Forrest D, Hofmann A, Hagey LR, Ling V. Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15; 305(4):G286-94. PMID: 23764895.
        View in: PubMed
      13. Ogawa S, Zhou B, Kimoto Y, Omura K, Kobayashi A, Higashi T, Mitamura K, Ikegawa S, Hagey LR, Hofmann A, Iida T. An efficient synthesis of 7a,12a-dihydroxy-4-cholesten-3-one and its biological precursor 7a-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis. Steroids. 2013 Sep; 78(9):927-37. PMID: 23707572.
        View in: PubMed
      14. Hagey LR, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann A, Iida T. A novel varanic acid epimer--(24R,25S)-3a,7a,12a,24-tetrahydroxy-5ß-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster. Steroids. 2012 Nov; 77(13):1510-21. PMID: 22986074.
        View in: PubMed
      15. Muto A, Takei H, Unno A, Murai T, Kurosawa T, Ogawa S, Iida T, Ikegawa S, Mori J, Ohtake A, Hoshina T, Mizuochi T, Kimura A, Hofmann A, Hagey LR, Nittono H. Detection of ?4-3-oxo-steroid 5ß-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 01; 900:24-31. PMID: 22695323.
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      16. Hofmann A. Herbert Falk: a vital force in the renaissance of bile acid research and bile acid therapy. Dig Dis. 2011; 29(1):23-36. PMID: 21691101.
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      17. Hagey LR, Iida T, Ogawa S, Adachi Y, Une M, Mushiake K, Maekawa M, Shimada M, Mano N, Hofmann A. Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3a,7a,24-trihydroxy-5ß-cholestan-27-oic acid and two epimers (25R and 25S) of 3a,7a-dihydroxy-5ß-cholestan-27-oic acid. Steroids. 2011 Sep-Oct; 76(10-11):1126-35. PMID: 21600907.
        View in: PubMed
      18. Ogawa S, Mitamura K, Ikegawa S, Krasowski MD, Hagey LR, Hofmann A, Iida T. Chemical synthesis of the (25R)- and (25S)-epimers of 3a,7a,12a-trihydroxy-5a-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates. Chem Phys Lipids. 2011 Jul; 164(5):368-77. PMID: 21554864.
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      19. Hofmann A. Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release. Hepatology. 2011 May; 53(5):1784. PMID: 21520190.
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      20. Denk GU, Maitz S, Wimmer R, Rust C, Invernizzi P, Ferdinandusse S, Kulik W, Fuchsbichler A, Fickert P, Trauner M, Hofmann A, Beuers U. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology. 2010 Nov; 52(5):1758-68. PMID: 21038414.
        View in: PubMed
      21. Hagey LR, Vidal N, Hofmann A, Krasowski MD. COMPLEX EVOLUTION OF BILE SALTS IN BIRDS. Auk. 2010 Oct; 127(4):820-831. PMID: 21113274.
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      22. Hagey LR, Lida T, Tamegai H, Ogawa S, Une M, Asahina K, Mushiake K, Goto T, Mano N, Goto J, Krasowski MD, Hofmann A. Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. Zoolog Sci. 2010 Jul; 27(7):565-73. PMID: 20608845; PMCID: PMC2901895.
      23. Hagey LR, Vidal N, Hofmann A, Krasowski MD. Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. BMC Evol Biol. 2010 May 06; 10:133. PMID: 20444292; PMCID: PMC2886068.
      24. Hagey LR, Møller PR, Hofmann A, Krasowski MD. Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. Physiol Biochem Zool. 2010 Mar-Apr; 83(2):308-21. PMID: 20113173; PMCID: PMC2845723.
      25. Hofmann A. Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last. Expert Rev Gastroenterol Hepatol. 2009 Oct; 3(5):461-4. PMID: 19817666.
        View in: PubMed
      26. Hofmann A, Hagey LR, Krasowski MD. Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res. 2010 Feb; 51(2):226-46. PMID: 19638645; PMCID: PMC2803226.
      27. Halilbasic E, Fiorotto R, Fickert P, Marschall HU, Moustafa T, Spirli C, Fuchsbichler A, Gumhold J, Silbert D, Zatloukal K, Langner C, Maitra U, Denk H, Hofmann A, Strazzabosco M, Trauner M. Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice. Hepatology. 2009 Jun; 49(6):1972-81. PMID: 19475687; PMCID: PMC3569724.
      28. Hofmann A. Bile acids: trying to understand their chemistry and biology with the hope of helping patients. Hepatology. 2009 May; 49(5):1403-18. PMID: 19296471.
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      29. Mitamura K, Watanabe S, Sakai T, Okihara R, Sogabe M, Wakamiya T, Hofmann A, Ikegawa S. Chemical synthesis of N-acetylcysteine conjugates of bile acids and in vivo formation in cholestatic rats as shown by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 01; 877(25):2630-8. PMID: 19346170.
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      30. Money ME, Hofmann A, Hagey LR, Walkowiak J, Talley NJ. Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. Pancreas. 2009 Mar; 38(2):232-3. PMID: 19238028.
        View in: PubMed
      31. Hofmann A. The enterohepatic circulation of bile acids in mammals: form and functions. Front Biosci (Landmark Ed). 2009 Jan 01; 14:2584-98. PMID: 19273221.
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      32. Hofmann A. In memoriam: Dr. Herbert Falk (1924-2008). Hepatology. 2009 Jan; 49(1):1-3. PMID: 19108004.
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      33. Hagey LR, Kakiyama G, Muto A, Iida T, Mushiake K, Goto T, Mano N, Goto J, Oliveira CA, Hofmann A. A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid. J Lipid Res. 2009 Apr; 50(4):651-7. PMID: 19011113; PMCID: PMC2656658.
      34. Hofmann A, Loening-Baucke V, Lavine JE, Hagey LR, Steinbach JH, Packard CA, Griffin TL, Chatfield DA. Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):598-606. PMID: 18955863.
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      35. Hofmann A, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci. 2008 Aug; 65(16):2461-83. PMID: 18488143.
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      36. Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann A, Krasowski MD. Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res. 2008 Jul; 49(7):1577-87. PMID: 18362391; PMCID: PMC2431107.
      37. Kakiyama G, Tamegai H, Iida T, Mitamura K, Ikegawa S, Goto T, Mano N, Goto J, Holz P, Hagey LR, Hofmann A. Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid. J Lipid Res. 2007 Dec; 48(12):2682-92. PMID: 17785716.
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      38. Hamilton JP, Xie G, Raufman JP, Hogan S, Griffin TL, Packard CA, Chatfield DA, Hagey LR, Steinbach JH, Hofmann A. Human cecal bile acids: concentration and spectrum. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G256-63. PMID: 17412828.
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      39. Hofmann A. Why bile acid glucuronidation is a minor pathway for conjugation of endogenous bile acids in man. Hepatology. 2007 Apr; 45(4):1083-4; author reply 1084-5. PMID: 17393523.
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      40. Hofmann A. Biliary secretion and excretion in health and disease: current concepts. Ann Hepatol. 2007 Jan-Mar; 6(1):15-27. PMID: 17297425.
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      41. Keely SJ, Scharl MM, Bertelsen LS, Hagey LR, Barrett KE, Hofmann A. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G290-7. PMID: 16901996.
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      42. Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann A, Knisely AS, Oude Elferink RP. Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology. 2006 Jul; 44(1):195-204. PMID: 16799980.
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      43. Sehayek E, Hagey LR, Fung YY, Duncan EM, Yu HJ, Eggertsen G, Björkhem I, Hofmann A, Breslow JL. Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. J Lipid Res. 2006 Sep; 47(9):2020-7. PMID: 16763287.
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      44. Hofmann A, Huet PM. Nasobiliary drainage for cholestatic pruritus. Hepatology. 2006 May; 43(5):1170-1. PMID: 16628631.
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      45. Kakiyama G, Iida T, Goto T, Mano N, Goto J, Nambara T, Hagey LR, Schteingart CD, Hofmann A. Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid. J Lipid Res. 2006 Jul; 47(7):1551-8. PMID: 16648547.
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      46. Hofmann A, Eckmann L. How bile acids confer gut mucosal protection against bacteria. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4333-4. PMID: 16537368; PMCID: PMC1450168.
      47. Fickert P, Wagner M, Marschall HU, Fuchsbichler A, Zollner G, Tsybrovskyy O, Zatloukal K, Liu J, Waalkes MP, Cover C, Denk H, Hofmann A, Jaeschke H, Trauner M. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb; 130(2):465-81. PMID: 16472600.
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      48. Hofmann A, Zakko SF, Lira M, Clerici C, Hagey LR, Lambert KK, Steinbach JH, Schteingart CD, Olinga P, Groothuis GM. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology. 2005 Dec; 42(6):1391-8. PMID: 16317695.
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      49. Combes B, Emerson SS, Flye NL, Munoz SJ, Luketic VA, Mayo MJ, McCashland TM, Zetterman RK, Peters MG, Di Bisceglie AM, Benner KG, Kowdley KV, Carithers RL, Rosoff L, Garcia-Tsao G, Boyer JL, Boyer TD, Martinez EJ, Bass NM, Lake JR, Barnes DS, Bonacini M, Lindsay KL, Mills AS, Markin RS, Rubin R, West AB, Wheeler DE, Contos MJ, Hofmann A. Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis. Hepatology. 2005 Nov; 42(5):1184-93. PMID: 16250039.
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      50. Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann A. A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res. 2005 Oct; 46(10):2221-32. PMID: 16061950.
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      51. Hofmann A. Increased deoxycholic acid absorption and gall stones in acromegalic patients treated with octreotide: more evidence for a connection between slow transit constipation and gall stones. Gut. 2005 May; 54(5):575-8. PMID: 15831896; PMCID: PMC1774479.
      52. Hofmann A. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev. 2004 Oct; 36(3-4):703-22. PMID: 15554243.
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      53. Hofmann A. Douglas B. McGill, 1929-2004. Gastroenterology. 2004 Jun; 126(7):1890-2. PMID: 15188184.
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      54. Kakiyama G, Iida T, Yoshimoto A, Goto T, Mano N, Goto J, Nambara T, Hagey LR, Hofmann A. Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat. J Lipid Res. 2004 Mar; 45(3):567-73. PMID: 14657194.
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      55. Hofmann A. Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry. Gut. 2003 Sep; 52(9):1239-41. PMID: 12912852; PMCID: PMC1773777.
      56. Porter JL, Fordtran JS, Santa Ana CA, Emmett M, Hagey LR, Macdonald EA, Hofmann A. Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med. 2003 Jun; 141(6):411-8. PMID: 12819639.
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      57. Lorenzo-Zúñiga V, Bartolí R, Planas R, Hofmann A, Viñado B, Hagey LR, Hernández JM, Mañé J, Alvarez MA, Ausina V, Gassull MA. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology. 2003 Mar; 37(3):551-7. PMID: 12601352.
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      58. Zeh N, Rossi SS, Hofmann A, Steinbach JH, Hagey LR, Oliver D, Stange J, Hassanein T. The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease. Liver Int. 2003; 23 Suppl 3:34-8. PMID: 12950959.
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      59. Iida T, Hikosaka M, Kakiyama G, Shiraishi K, Schteingart CD, Hagey LR, Ton-Nu HT, Hofmann A, Mano N, Goto J, Nambara T. Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids. Chem Pharm Bull (Tokyo). 2002 Oct; 50(10):1327-34. PMID: 12372858.
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      60. Meng LJ, Wang P, Wolkoff AW, Kim RB, Tirona RG, Hofmann A, Pang KS. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology. 2002 May; 35(5):1031-40. PMID: 11981753.
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      61. Hofmann A. Cholestatic liver disease: pathophysiology and therapeutic options. Liver. 2002; 22 Suppl 2:14-9. PMID: 12220297.
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      62. Hofmann A. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med. 1999 Dec 13-27; 159(22):2647-58. PMID: 10597755.
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      63. Hofmann A. Bile Acids: The Good, the Bad, and the Ugly. News Physiol Sci. 1999 Feb; 14:24-29. PMID: 11390813.
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