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Edward Dennis

Title(s)Professor, Pharmacology
SchoolAcademic Aff
Phone858-534-3055
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    Collapse Research 
    Collapse Research Activities and Funding
    LIPIDOMICS BASED DIAGNOSTICS FOR NONALCOHOLIC STEATOHEPATITIS
    NIH/NIDDK R01DK105961Aug 26, 2015 - May 31, 2019
    Role: Principal Investigator
    Impact of Lipidomics Conference Series
    NIH/NIGMS R13GM106571Feb 15, 2014 - Jan 31, 2017
    Role: Principal Investigator
    LIPID MAPS
    NIH/NIGMS U54GM069338Aug 12, 2003 - Jul 31, 2014
    Role: Principal Investigator
    Lipid Maps
    NIH/NIGMS R24GM067877Sep 30, 2002 - Sep 30, 2003
    Role: Principal Investigator
    Regulation of Lipid Mediators in Spinal Microglia and Astrocytes
    NIH/NIGMS R01GM064611Sep 17, 2002 - Jan 31, 2013
    Role: Principal Investigator
    LYSOPHOSPHOLIPASES
    NIH/NIGMS R01GM051606Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    FASEB SUMMER CONFERECE ON PHOSPHOLIPASES
    NIH/NIGMS R13GM047924Jun 1, 1992 - May 31, 1993
    Role: Principal Investigator
    REGULATION OF PROSTAGLANDIN BIOSYNTHESIS IN PARTURITION
    NIH/NICHD R01HD026171Sep 1, 1989 - Dec 31, 2000
    Role: Principal Investigator
    1989 LIPID METABOLISM GORDON RESEARCH CONFERENCE
    NIH/NIDDK R13DK041231Jul 1, 1989 - May 31, 1990
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Action of Lipolytic Enzymes
    NIH/NIGMS R01GM020501Jun 1, 1977 - Dec 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. Correction to "Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)". ACS Omega. 2019 Jun 30; 4(6):10714. PMID: 31460169.
      View in: PubMed
    2. Declèves AE, Mathew AV, Armando AM, Han X, Dennis EA, Quehenberger O, Sharma K. AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. J Lipid Res. 2019 May; 60(5):937-952. PMID: 30862696.
      View in: PubMed
    3. Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G. ß-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit ß-Cell Apoptosis. J Med Chem. 2019 Mar 28; 62(6):2916-2927. PMID: 30798607.
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    4. Mouchlis VD, Armando A, Dennis EA. Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. J Med Chem. 2019 Feb 28; 62(4):1999-2007. PMID: 30615445.
      View in: PubMed
    5. Feuerherm AJ, Dennis EA, Johansen B. Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis. Arthritis Res Ther. 2019 Jan 21; 21(1):29. PMID: 30665457.
      View in: PubMed
    6. Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 Mar 21; 26(3):433-442.e4. PMID: 30661990.
      View in: PubMed
    7. O'Donnell VB, Dennis EA, Wakelam MJO, Subramaniam S. LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training. Sci Signal. 2019 Jan 08; 12(563). PMID: 30622195.
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    8. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. PMID: 30130298.
      View in: PubMed
    9. Quehenberger O, Dahlberg-Wright S, Jiang J, Armando AM, Dennis EA. Quantitative determination of esterified eicosanoids and related oxygenated metabolites after base hydrolysis. J Lipid Res. 2018 Dec; 59(12):2436-2445. PMID: 30323111.
      View in: PubMed
    10. Mouchlis VD, Dennis EA. Phospholipase A2 catalysis and lipid mediator lipidomics. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun; 1864(6):766-771. PMID: 30905345.
      View in: PubMed
    11. Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešic M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR. MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. J Lipid Res. 2018 Oct; 59(10):2001-2017. PMID: 30115755.
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    12. Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2). ACS Omega. 2018 Aug 31; 3(8):8843-8853. PMID: 30197994.
      View in: PubMed
    13. Mouchlis VD, Chen Y, McCammon JA, Dennis EA. Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity. J Am Chem Soc. 2018 03 07; 140(9):3285-3291. PMID: 29342349.
      View in: PubMed
    14. Navratil AR, Shchepinov MS, Dennis EA. Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo. J Am Chem Soc. 2018 01 10; 140(1):235-243. PMID: 29206462.
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    15. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. PMID: 29404441.
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    16. Vasquez AM, Mouchlis VD, Dennis EA. Review of four major distinct types of human phospholipase A2. Adv Biol Regul. 2018 01; 67:212-218. PMID: 29248300.
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    17. Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S. Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res. 2017 12; 58(12):2275-2288. PMID: 28986437.
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    18. Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, Kokotos G. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Sci Rep. 2017 08 01; 7(1):7025. PMID: 28765606.
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    19. Brown CR, Dennis EA. Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis. Biochimie. 2017 Oct; 141:86-90. PMID: 28630010.
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    20. Smyrniotou A, Kokotou MG, Mouchlis VD, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V. 2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors. Bioorg Med Chem. 2017 02 01; 25(3):926-940. PMID: 28034646.
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    21. Sokolowska M, Chen LY, Liu Y, Martinez-Anton A, Logun C, Alsaaty S, Cuento RA, Cai R, Sun J, Quehenberger O, Armando AM, Dennis EA, Levine SJ, Shelhamer JH. Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma. J Allergy Clin Immunol. 2017 04; 139(4):1379-1383. PMID: 27826094.
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    22. Dennis EA. Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease. J Biol Chem. 2016 Nov 18; 291(47):24431-24448. PMID: 27555328.
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    23. Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorg Med Chem. 2016 10 01; 24(19):4544-4554. PMID: 27522578.
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    24. Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 10 15; 24(20):4801-4811. PMID: 27320659.
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    25. Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships. J Med Chem. 2016 05 12; 59(9):4403-14. PMID: 27087127.
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    26. Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S. Computational Modeling of Competitive Metabolism between ?3- and ?6-Polyunsaturated Fatty Acids in Inflammatory Macrophages. J Phys Chem B. 2016 08 25; 120(33):8346-53. PMID: 27063350.
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    27. Mouchlis VD, Dennis EA. Membrane and inhibitor interactions of intracellular phospholipases A2. Adv Biol Regul. 2016 05; 61:17-24. PMID: 26774606.
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    28. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug; 15(8):511-23. PMID: 26139350.
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    29. Dennis EA. Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease. J Lipid Res. 2015 Jul; 56(7):1245-7. PMID: 26031662.
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    30. Mouchlis VD, Bucher D, McCammon JA, Dennis EA. Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E516-25. PMID: 25624474.
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    31. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-36. PMID: 25598080.
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    32. Astarita G, Kendall AC, Dennis EA, Nicolaou A. Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids. Biochim Biophys Acta. 2015 Apr; 1851(4):456-68. PMID: 25486530.
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    33. Loomba R, Quehenberger O, Armando A, Dennis EA. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res. 2015 Jan; 56(1):185-92. PMID: 25404585.
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    34. Baker PR, Armando AM, Campbell JL, Quehenberger O, Dennis EA. Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies. J Lipid Res. 2014 Nov; 55(11):2432-42. PMID: 25225680.
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    35. Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25; 57(18):7523-35. PMID: 25152071.
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    36. Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA. Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12746-51. PMID: 25139986.
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    37. Jiao J, Ishikawa TO, Dumlao DS, Norris PC, Magyar CE, Mikulec C, Catapang A, Dennis EA, Fischer SM, Herschman HR. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res. 2014 Nov; 12(11):1677-88. PMID: 25063587.
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    38. Wang Y, Armando AM, Quehenberger O, Yan C, Dennis EA. Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples. J Chromatogr A. 2014 Sep 12; 1359:60-9. PMID: 25074422.
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    39. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. PMID: 24613321.
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    40. Kihara Y, Gupta S, Maurya MR, Armando A, Shah I, Quehenberger O, Glass CK, Dennis EA, Subramaniam S. Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophys J. 2014 Feb 18; 106(4):966-75. PMID: 24559999.
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    41. Jiao J, Mikulec C, Ishikawa TO, Magyar C, Dumlao DS, Dennis EA, Fischer SM, Herschman H. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. 2014 Jun; 35(6):1310-9. PMID: 24469308.
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    42. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145. PMID: 24376657.
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    43. Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13; 288(50):35812-23. PMID: 24189069.
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    44. Kennelly PJ, Bond JS, Masters BS, Dennis EA, Brenner C, Raben DM. Desperately seeking Flexner: time to reemphasize basic science in medical education. Acad Med. 2013 Oct; 88(10):1405-6. PMID: 24064614.
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    45. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-214. PMID: 24074869.
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    46. Norris PC, Dennis EA. A lipidomic perspective on inflammatory macrophage eicosanoid signaling. Adv Biol Regul. 2014 Jan; 54:99-110. PMID: 24113376.
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    47. Merrill AH, Dennis EA, McDonald JG, Fahy E. Lipidomics technologies at the end of the first decade and the beginning of the next. Adv Nutr. 2013 Sep 01; 4(5):565-7. PMID: 24038259.
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    48. Bucher D, Hsu YH, Mouchlis VD, Dennis EA, McCammon JA. Insertion of the Ca²?-independent phospholipase A2 into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations. PLoS Comput Biol. 2013; 9(7):e1003156. PMID: 23935474.
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    49. Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15; 21(18):5823-9. PMID: 23916152.
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    50. Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum JL, Koschinsky ML, Tsimikas S. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res. 2013 Oct; 54(10):2815-30. PMID: 23828779.
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    51. Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A. Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell. 2013 Jul 03; 154(1):213-27. PMID: 23827684.
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    52. Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res. 2013 Sep; 54(9):2525-42. PMID: 23776196.
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    53. Hsu YH, Dumlao DS, Cao J, Dennis EA. Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. PLoS One. 2013; 8(3):e59267. PMID: 23533611.
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    54. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May; 27(5):1939-49. PMID: 23382512.
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    55. Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL, McCammon JA, Dennis EA. Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics. J Am Chem Soc. 2013 Jan 30; 135(4):1330-7. PMID: 23256506.
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    56. Cao J, Burke JE, Dennis EA. Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem. 2013 Jan 18; 288(3):1806-13. PMID: 23209293.
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    57. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. J Lipid Res. 2013 Jan; 54(1):127-33. PMID: 23089916.
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    58. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28; 151(1):138-52. PMID: 23021221.
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    59. van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. J Lipid Res. 2012 Dec; 53(12):2773-90. PMID: 22969153.
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    60. Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao JL, Dennis EA, Moise AR. Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. J Biol Chem. 2012 Oct 12; 287(42):35260-74. PMID: 22923616.
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    61. Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hanks JH, Halpin R, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR. Dietary fish oil substitution alters the eicosanoid profile in ankle joints of mice during Lyme infection. J Nutr. 2012 Aug; 142(8):1582-9. PMID: 22695969.
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    62. Norris PC, Dennis EA. Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8517-22. PMID: 22586114.
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    63. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6721-6. PMID: 22493235.
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    64. Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA. The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6036-41. PMID: 22492977.
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    65. Sabidó E, Quehenberger O, Shen Q, Chang CY, Shah I, Armando AM, Andreyev A, Vitek O, Dennis EA, Aebersold R. Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism. Mol Cell Proteomics. 2012 Jul; 11(7):M111.014746. PMID: 22361236.
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    66. Sud M, Fahy E, Cotter D, Dennis EA, Subramaniam S. LIPID MAPS-Nature Lipidomics Gateway: An Online Resource for Students and Educators Interested in Lipids. J Chem Educ. 2012 Jan 10; 89(2):291-292. PMID: 24764601.
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    67. Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics. J Chem Inf Model. 2012 Jan 23; 52(1):243-54. PMID: 22196172.
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    68. Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K. Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. J Biol Chem. 2012 Mar 30; 287(14):11469-80. PMID: 22199362.
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    69. Quehenberger O, Dennis EA. The human plasma lipidome. N Engl J Med. 2011 Nov 10; 365(19):1812-23. PMID: 22070478.
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    70. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011 Dec; 152(12):2881-91. PMID: 22019135.
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    71. Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev. 2011 Oct 12; 111(10):6130-85. PMID: 21910409.
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    72. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. FASEB J. 2011 Dec; 25(12):4240-52. PMID: 21868473.
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    73. Quehenberger O, Armando AM, Dennis EA. High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry. Biochim Biophys Acta. 2011 Nov; 1811(11):648-56. PMID: 21787881.
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    74. Dumlao DS, Buczynski MW, Norris PC, Harkewicz R, Dennis EA. High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines. Biochim Biophys Acta. 2011 Nov; 1811(11):724-36. PMID: 21689782.
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    75. Norris PC, Reichart D, Dumlao DS, Glass CK, Dennis EA. Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. J Leukoc Biol. 2011 Sep; 90(3):563-74. PMID: 21653236.
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    76. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic a-helix. Biochemistry. 2011 Jun 14; 50(23):5314-21. PMID: 21553808.
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    77. Quehenberger O, Yamashita T, Armando AM, Dennis EA, Palinski W. Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol. 2011 Aug; 205(2):156.e15-25. PMID: 21621186.
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    78. Harkewicz R, Dennis EA. Applications of mass spectrometry to lipids and membranes. Annu Rev Biochem. 2011; 80:301-25. PMID: 21469951.
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    79. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17; 285(51):39976-85. PMID: 20923771.
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    80. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. PMID: 20710028.
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    81. Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol. 2010 Aug; 160(7):1754-64. PMID: 20649577.
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    82. Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res. 2010 Nov; 51(11):3299-305. PMID: 20671299.
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    83. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA. Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res. 2010 Sep; 51(9):2785-97. PMID: 20574076.
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    84. Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem. 2010 Aug; 114(4):981-93. PMID: 20492349.
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    85. Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13; 53(9):3602-10. PMID: 20369880.
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    86. Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med. 2010 Mar; 16(3):313-8. PMID: 20154695.
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    87. Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. Application of proteomic marker ensembles to subcellular organelle identification. Mol Cell Proteomics. 2010 Feb; 9(2):388-402. PMID: 19884172.
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    88. Blaho VA, Buczynski MW, Dennis EA, Brown CR. Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. J Immunol. 2009 Nov 01; 183(9):5644-53. PMID: 19843949.
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    89. Hsu YH, Burke JE, Li S, Woods VL, Dennis EA. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009 Aug 28; 284(35):23652-61. PMID: 19556238.
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    90. Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL, McCammon JA, Dennis EA. Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. J Am Chem Soc. 2009 Jun 17; 131(23):8083-91. PMID: 19459633.
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    91. Gupta S, Maurya MR, Stephens DL, Dennis EA, Subramaniam S. An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis. Biophys J. 2009 Jun 03; 96(11):4542-51. PMID: 19486676.
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    92. Blaho VA, Buczynski MW, Brown CR, Dennis EA. Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. J Biol Chem. 2009 Aug 07; 284(32):21599-612. PMID: 19487688.
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    93. Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 01; 17(13):4833-43. PMID: 19443224.
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    94. Dennis EA, Witztum JL. Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1. PMID: 19346336.
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    95. Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res. 2009 Jun; 50(6):1015-38. PMID: 19244215.
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    96. Grkovich A, Armando A, Quehenberger O, Dennis EA. TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent. Biochim Biophys Acta. 2009 Oct; 1791(10):975-82. PMID: 19230851.
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    97. Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G, David S. Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain. 2009 May; 132(Pt 5):1221-35. PMID: 19218359.
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    98. Dennis EA. Lipidomics joins the omics evolution. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2089-90. PMID: 19211786.
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    99. Grkovich A, Dennis EA. Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling. Adv Enzyme Regul. 2009; 49(1):114-20. PMID: 19534028.
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    100. Dennis EA. Founding, early history, and transformation of the Journal for Lipid Research to an American Society of Biochemistry and Molecular Biology journal. J Lipid Res. 2009 Apr; 50 Suppl:S3-8. PMID: 19116414.
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    101. Baskakis C, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25; 51(24):8027-37. PMID: 19053783.
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    102. Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res. 2009 Apr; 50 Suppl:S9-14. PMID: 19098281.
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    103. Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res. 2009 Apr; 50 Suppl:S237-42. PMID: 19011112.
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    104. Quehenberger O, Armando A, Dumlao D, Stephens DL, Dennis EA. Lipidomics analysis of essential fatty acids in macrophages. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov; 79(3-5):123-9. PMID: 18996688.
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    105. Antonopoulou G, Barbayianni E, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15; 16(24):10257-69. PMID: 18993078.
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    106. Burke JE, Dennis EA. Phospholipase A2 biochemistry. Cardiovasc Drugs Ther. 2009 Feb; 23(1):49-59. PMID: 18931897.
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    107. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. PMID: 18840708.
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    108. Antonopoulou G, Magrioti V, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2. J Pept Sci. 2008 Oct; 14(10):1111-20. PMID: 18618424.
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    109. Jacobsen FE, Buczynski MW, Dennis EA, Cohen SM. A macrophage cell model for selective metalloproteinase inhibitor design. Chembiochem. 2008 Sep 01; 9(13):2087-95. PMID: 18666306.
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    110. Burke JE, Hsu YH, Deems RA, Li S, Woods VL, Dennis EA. A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem. 2008 Nov 07; 283(45):31227-36. PMID: 18753135.
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    111. López-Vales R, Navarro X, Shimizu T, Baskakis C, Kokotos G, Constantinou-Kokotou V, Stephens D, Dennis EA, David S. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct; 131(Pt 10):2620-31. PMID: 18718965.
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    112. Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry. 2008 Jun 17; 47(24):6451-9. PMID: 18500818.
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    113. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. PMID: 18263582.
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    114. Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL, Dennis EA. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2008 Apr 11; 283(15):9820-7. PMID: 18211893.
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    115. Moutevelis-Minakakis P, Neokosmidi A, Filippakou M, Stephens D, Dennis EA, Kokotos G. Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2. J Pept Sci. 2007 Oct; 13(10):634-41. PMID: 17631670.
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    116. Six DA, Barbayianni E, Loukas V, Constantinou-Kokotou V, Hadjipavlou-Litina D, Stephens D, Wong AC, Magrioti V, Moutevelis-Minakakis P, Baker SF, Dennis EA, Kokotos G. Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2. J Med Chem. 2007 Aug 23; 50(17):4222-35. PMID: 17672443.
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    117. Buczynski MW, Stephens DL, Bowers-Gentry RC, Grkovich A, Deems RA, Dennis EA. TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells. J Biol Chem. 2007 Aug 03; 282(31):22834-47. PMID: 17535806.
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    118. Deems R, Buczynski MW, Bowers-Gentry R, Harkewicz R, Dennis EA. Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry. Methods Enzymol. 2007; 432:59-82. PMID: 17954213.
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    119. Schmelzer K, Fahy E, Subramaniam S, Dennis EA. The lipid maps initiative in lipidomics. Methods Enzymol. 2007; 432:171-83. PMID: 17954217.
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    120. Harkewicz R, Fahy E, Andreyev A, Dennis EA. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. J Biol Chem. 2007 Feb 02; 282(5):2899-910. PMID: 17135246.
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    121. Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. LMSD: LIPID MAPS structure database. Nucleic Acids Res. 2007 Jan; 35(Database issue):D527-32. PMID: 17098933.
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    122. Grkovich A, Johnson CA, Buczynski MW, Dennis EA. Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent. J Biol Chem. 2006 Nov 03; 281(44):32978-87. PMID: 16950767.
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    123. Schaloske RH, Dennis EA. The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta. 2006 Nov; 1761(11):1246-59. PMID: 16973413.
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    124. Stephens D, Barbayianni E, Constantinou-Kokotou V, Peristeraki A, Six DA, Cooper J, Harkewicz R, Deems RA, Dennis EA, Kokotos G. Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides. J Med Chem. 2006 May 04; 49(9):2821-8. PMID: 16640343.
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    125. Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, Bowers-Gentry RC, Buczynski MW, Cooper JA, Deems RA, Dennis EA. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res. 2006 May; 47(5):1097-111. PMID: 16479018.
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    126. Greenwood-Van Meerveld B, Venkova K, Hicks G, Dennis E, Crowell MD. Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil. 2006 Jan; 18(1):76-86. PMID: 16371086.
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    127. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. PMID: 16203828.
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    128. Kessen UA, Schaloske RH, Stephens DL, Killermann Lucas K, Dennis EA. PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS. J Lipid Res. 2005 Nov; 46(11):2488-96. PMID: 16150819.
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    129. Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):223-34. PMID: 16099407.
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    130. Lucas KK, Dennis EA. Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):235-48. PMID: 16099408.
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    131. Shirai Y, Balsinde J, Dennis EA. Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs. Biochim Biophys Acta. 2005 Jul 15; 1735(2):119-29. PMID: 15967714.
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    132. Constantinou-Kokotou V, Peristeraki A, Kokotos CG, Six DA, Dennis EA. Synthesis and activity of 2-oxoamides containing long chain beta-amino acids. J Pept Sci. 2005 Jul; 11(7):431-5. PMID: 15635664.
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    133. Winstead MV, Lucas KK, Dennis EA. Group IV cytosolic phospholipase A2 mediates arachidonic acid release in H9c2 rat cardiomyocyte cells in response to hydrogen peroxide. Prostaglandins Other Lipid Mediat. 2005 Dec; 78(1-4):55-66. PMID: 16303605.
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    134. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. PMID: 15685208.
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    135. Schaloske RH, Provins JW, Kessen UA, Dennis EA. Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. Biochim Biophys Acta. 2005 Feb 21; 1687(1-3):64-75. PMID: 15708354.
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    136. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. PMID: 15722563.
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    137. Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76. PMID: 15722561.
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    138. Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL. Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience. 2005; 133(2):543-53. PMID: 15885922.
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    139. Kokotos G, Six DA, Loukas V, Smith T, Constantinou-Kokotou V, Hadjipavlou-Litina D, Kotsovolou S, Chiou A, Beltzner CC, Dennis EA. Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo. J Med Chem. 2004 Jul 01; 47(14):3615-28. PMID: 15214789.
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    140. Boegeman SC, Deems RA, Dennis EA. Phospholipid binding and the activation of group IA secreted phospholipase A2. Biochemistry. 2004 Apr 06; 43(13):3907-16. PMID: 15049698.
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    141. Lucas KK, Dennis EA. The ABC's of Group IV cytosolic phospholipase A2. Biochim Biophys Acta. 2004 Mar 22; 1636(2-3):213-8. PMID: 15164769.
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    142. Balboa MA, Shirai Y, Gaietta G, Ellisman MH, Balsinde J, Dennis EA. Localization of group V phospholipase A2 in caveolin-enriched granules in activated P388D1 macrophage-like cells. J Biol Chem. 2003 Nov 28; 278(48):48059-65. PMID: 12963740.
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    143. Phillips RM, Six DA, Dennis EA, Ghosh P. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem. 2003 Oct 17; 278(42):41326-32. PMID: 12915403.
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    144. Six DA, Dennis EA. Essential Ca(2+)-independent role of the group IVA cytosolic phospholipase A(2) C2 domain for interfacial activity. J Biol Chem. 2003 Jun 27; 278(26):23842-50. PMID: 12672805.
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    145. Whiles JA, Deems R, Vold RR, Dennis EA. Bicelles in structure-function studies of membrane-associated proteins. Bioorg Chem. 2002 Dec; 30(6):431-42. PMID: 12642127.
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    146. Balsinde J, Winstead MV, Dennis EA. Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett. 2002 Oct 30; 531(1):2-6. PMID: 12401193.
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    147. Balboa MA, Varela-Nieto I, Killermann Lucas K, Dennis EA. Expression and function of phospholipase A(2) in brain. FEBS Lett. 2002 Oct 30; 531(1):12-7. PMID: 12401195.
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    148. Kokotos G, Kotsovolou S, Six DA, Constantinou-Kokotou V, Beltzner CC, Dennis EA. Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2). J Med Chem. 2002 Jul 04; 45(14):2891-3. PMID: 12086476.
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    149. Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 01; 277(9):7010-20. PMID: 11744722.
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    150. Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, Hörkkö S, Palinski W, Quehenberger O, Shaw P, Steinberg D, Terpstra V, Witztum JL. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann N Y Acad Sci. 2001 Dec; 947:214-22; discussion 222-3. PMID: 11795269.
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    151. Bernatchez PN, Winstead MV, Dennis EA, Sirois MG. VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. Br J Pharmacol. 2001 Sep; 134(1):197-205. PMID: 11522612.
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    152. Balboa MA, Balsinde J, Dennis EA. Inflammatory activation of prostaglandin production by microglial cells antagonized by amyloid peptide. Biochem Biophys Res Commun. 2001 Jan 19; 280(2):558-60. PMID: 11162555.
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    153. Six DA, Dennis EA. The expanding superfamily of phospholipase A(2) enzymes: classification and characterization. Biochim Biophys Acta. 2000 Oct 31; 1488(1-2):1-19. PMID: 11080672.
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    154. Winstead MV, Balsinde J, Dennis EA. Calcium-independent phospholipase A(2): structure and function. Biochim Biophys Acta. 2000 Oct 31; 1488(1-2):28-39. PMID: 11080674.
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    155. Balsinde J, Balboa MA, Dennis EA. Identification of a third pathway for arachidonic acid mobilization and prostaglandin production in activated P388D1 macrophage-like cells. J Biol Chem. 2000 Jul 21; 275(29):22544-9. PMID: 10811815.
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    156. Balsinde J, Balboa MA, Li WH, Llopis J, Dennis EA. Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. J Immunol. 2000 May 15; 164(10):5398-402. PMID: 10799904.
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    157. Wang A, Johnson CA, Jones Y, Ellisman MH, Dennis EA. Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells. Biochim Biophys Acta. 2000 Apr 12; 1484(2-3):207-14. PMID: 10760470.
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    158. Balsinde J, Balboa MA, Dennis EA. Group IV cytosolic phospholipase A2 activation by diacylglycerol pyrophosphate in murine P388D1 macrophages. Ann N Y Acad Sci. 2000 Apr; 905:11-5. PMID: 10818437.
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    159. Boullier A, Gillotte KL, Hörkkö S, Green SR, Friedman P, Dennis EA, Witztum JL, Steinberg D, Quehenberger O. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem. 2000 Mar 31; 275(13):9163-9. PMID: 10734051.
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    160. Johansen B, Rakkestad K, Balboa MA, Dennis EA. Expression of cytosolic and secreted forms of phospholipase A(2) and cyclooxygenases in human placenta, fetal membranes, and chorionic cell lines. Prostaglandins Other Lipid Mediat. 2000 Mar; 60(4-6):119-25. PMID: 10751642.
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    161. Balsinde J, Balboa MA, Yedgar S, Dennis EA. Group V phospholipase A(2)-mediated oleic acid mobilization in lipopolysaccharide-stimulated P388D(1) macrophages. J Biol Chem. 2000 Feb 18; 275(7):4783-6. PMID: 10671511.
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    162. Dennis EA. Phospholipase A2 in eicosanoid generation. Am J Respir Crit Care Med. 2000 Feb; 161(2 Pt 2):S32-5. PMID: 10673223.
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    163. Bianco ID, Balsinde J, Beltramo DM, Castagna LF, Landa CA, Dennis EA. Chitosan-induced phospholipase A2 activation and arachidonic acid mobilization in P388D1 macrophages. FEBS Lett. 2000 Jan 28; 466(2-3):292-4. PMID: 10682846.
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    164. Hughes P, Dennis E, Whitecross M, Llewellyn D, Gage P. The cytotoxic plant protein, beta-purothionin, forms ion channels in lipid membranes. J Biol Chem. 2000 Jan 14; 275(2):823-7. PMID: 10625613.
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    165. Balboa MA, Balsinde J, Dennis EA. Phosphorylation of cytosolic group IV phospholipase A(2) is necessary but not sufficient for Arachidonic acid release in P388D(1) macrophages. Biochem Biophys Res Commun. 2000 Jan 07; 267(1):145-8. PMID: 10623589.
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    166. Lefkowitz LJ, Shinohara H, Dennis EA. Human group-V phospholipase-A2 expression in Pichia pastoris and its role in eicosanoid generation. Ernst Schering Res Found Workshop. 2000; (31):25-52. PMID: 10943326.
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    167. Balboa MA, Balsinde J, Johnson CA, Dennis EA. Regulation of arachidonic acid mobilization in lipopolysaccharide-activated P388D(1) macrophages by adenosine triphosphate. J Biol Chem. 1999 Dec 17; 274(51):36764-8. PMID: 10593984.
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    168. Lefkowitz LJ, Deems RA, Dennis EA. Expression of group IA phospholipase A2 in Pichia pastoris: identification of a phosphatidylcholine activator site using site-directed mutagenesis. Biochemistry. 1999 Oct 26; 38(43):14174-84. PMID: 10571991.
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    169. Johnson CA, Balboa MA, Balsinde J, Dennis EA. Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells. J Biol Chem. 1999 Sep 24; 274(39):27689-93. PMID: 10488110.
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    170. Balsinde J, Shinohara H, Lefkowitz LJ, Johnson CA, Balboa MA, Dennis EA. Group V phospholipase A(2)-dependent induction of cyclooxygenase-2 in macrophages. J Biol Chem. 1999 Sep 10; 274(37):25967-70. PMID: 10473537.
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    171. Yang HC, Mosior M, Ni B, Dennis EA. Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain. J Neurochem. 1999 Sep; 73(3):1278-87. PMID: 10461922.
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    172. Ghomashchi F, Loo R, Balsinde J, Bartoli F, Apitz-Castro R, Clark JD, Dennis EA, Gelb MH. Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A(2): structure-function studies with vesicle, micelle, and membrane assays. Biochim Biophys Acta. 1999 Aug 20; 1420(1-2):45-56. PMID: 10446289.
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    173. Wang A, Dennis EA. Mammalian lysophospholipases. Biochim Biophys Acta. 1999 Jul 09; 1439(1):1-16. PMID: 10395961.
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    174. Chang MK, Bergmark C, Laurila A, Hörkkö S, Han KH, Friedman P, Dennis EA, Witztum JL. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6353-8. PMID: 10339591.
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    175. Bird DA, Gillotte KL, Hörkkö S, Friedman P, Dennis EA, Witztum JL, Steinberg D. Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6347-52. PMID: 10339590.
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    176. Yang HC, Mosior M, Johnson CA, Chen Y, Dennis EA. Group-specific assays that distinguish between the four major types of mammalian phospholipase A2. Anal Biochem. 1999 May 01; 269(2):278-88. PMID: 10221999.
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    177. Shinohara H, Balboa MA, Johnson CA, Balsinde J, Dennis EA. Regulation of delayed prostaglandin production in activated P388D1 macrophages by group IV cytosolic and group V secretory phospholipase A2s. J Biol Chem. 1999 Apr 30; 274(18):12263-8. PMID: 10212194.
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    178. Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA. A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. Biochim Biophys Acta. 1999 Feb 25; 1437(2):157-69. PMID: 10064899.
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    179. Hörkkö S, Bird DA, Miller E, Itabe H, Leitinger N, Subbanagounder G, Berliner JA, Friedman P, Dennis EA, Curtiss LK, Palinski W, Witztum JL. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J Clin Invest. 1999 Jan; 103(1):117-28. PMID: 9884341.
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    180. Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol. 1999; 39:175-89. PMID: 10331081.
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    181. Balboa MA, Balsinde J, Dillon DA, Carman GM, Dennis EA. Proinflammatory macrophage-activating properties of the novel phospholipid diacylglycerol pyrophosphate. J Biol Chem. 1999 Jan 01; 274(1):522-6. PMID: 9867874.
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    182. Chen Y, Dennis EA. Expression and characterization of human group V phospholipase A2. Biochim Biophys Acta. 1998 Oct 02; 1394(1):57-64. PMID: 9767110.
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    183. Glover J, Grelon M, Craig S, Chaudhury A, Dennis E. Cloning and characterization of MS5 from Arabidopsis: a gene critical in male meiosis. Plant J. 1998 Aug; 15(3):345-56. PMID: 9750346.
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    184. Balsinde J, Balboa MA, Dennis EA. Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):7951-6. PMID: 9653121.
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    185. Lio YC, Dennis EA. Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2. Biochim Biophys Acta. 1998 Jun 15; 1392(2-3):320-32. PMID: 9630702.
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    186. Segelke BW, Nguyen D, Chee R, Xuong NH, Dennis EA. Structures of two novel crystal forms of Naja naja naja phospholipase A2 lacking Ca2+ reveal trimeric packing. J Mol Biol. 1998 May 29; 279(1):223-32. PMID: 9636712.
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    187. Balboa MA, Balsinde J, Dennis EA. Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amnionic WISH cells. J Biol Chem. 1998 Mar 27; 273(13):7684-90. PMID: 9516474.
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    188. Mosior M, Six DA, Dennis EA. Group IV cytosolic phospholipase A2 binds with high affinity and specificity to phosphatidylinositol 4,5-bisphosphate resulting in dramatic increases in activity. J Biol Chem. 1998 Jan 23; 273(4):2184-91. PMID: 9442060.
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    189. Balsinde J, Balboa MA, Dennis EA. Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages. J Biol Chem. 1997 Nov 14; 272(46):29317-21. PMID: 9361012.
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    190. Wang A, Loo R, Chen Z, Dennis EA. Regiospecificity and catalytic triad of lysophospholipase I. J Biol Chem. 1997 Aug 29; 272(35):22030-6. PMID: 9268342.
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    191. Balsinde J, Balboa MA, Dennis EA. Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. J Biol Chem. 1997 Aug 15; 272(33):20373-7. PMID: 9252342.
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    192. Loo RW, Conde-Frieboes K, Reynolds LJ, Dennis EA. Activation, inhibition, and regiospecificity of the lysophospholipase activity of the 85-kDa group IV cytosolic phospholipase A2. J Biol Chem. 1997 Aug 01; 272(31):19214-9. PMID: 9235913.
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    193. Balsinde J, Dennis EA. Function and inhibition of intracellular calcium-independent phospholipase A2. J Biol Chem. 1997 Jun 27; 272(26):16069-72. PMID: 9195897.
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    194. Wang A, Deems RA, Dennis EA. Cloning, expression, and catalytic mechanism of murine lysophospholipase I. J Biol Chem. 1997 May 09; 272(19):12723-9. PMID: 9139730.
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    195. Balboa MA, Balsinde J, Jones SS, Dennis EA. Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells. J Biol Chem. 1997 Mar 28; 272(13):8576-80. PMID: 9079688.
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    196. Balsinde J, Balboa MA, Insel PA, Dennis EA. Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages. Biochem J. 1997 Feb 01; 321 ( Pt 3):805-9. PMID: 9032469.
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    197. Balsinde J, Dennis EA. Function of calcium-independent phospholipase A2 in arachidonic acid metabolism in P388D1 macrophages. Adv Exp Med Biol. 1997; 407:99-103. PMID: 9321938.
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    198. Dennis EA. The growing phospholipase A2 superfamily of signal transduction enzymes. Trends Biochem Sci. 1997 Jan; 22(1):1-2. PMID: 9020581.
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    199. Balsinde J, Dennis EA. Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages. J Biol Chem. 1996 Dec 13; 271(50):31937-41. PMID: 8943239.
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    200. Balboa MA, Balsinde J, Winstead MV, Tischfield JA, Dennis EA. Novel group V phospholipase A2 involved in arachidonic acid mobilization in murine P388D1 macrophages. J Biol Chem. 1996 Dec 13; 271(50):32381-4. PMID: 8943302.
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    201. Pickard RT, Chiou XG, Strifler BA, DeFelippis MR, Hyslop PA, Tebbe AL, Yee YK, Reynolds LJ, Dennis EA, Kramer RM, Sharp JD. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem. 1996 Aug 09; 271(32):19225-31. PMID: 8702602.
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    202. Lio YC, Reynolds LJ, Balsinde J, Dennis EA. Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta. 1996 Jul 12; 1302(1):55-60. PMID: 8695655.
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    203. Balsinde J, Dennis EA. Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages. J Biol Chem. 1996 Mar 22; 271(12):6758-65. PMID: 8636097.
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    204. Balsinde J, Dennis EA. The incorporation of arachidonic acid into triacylglycerol in P388D1 macrophage-like cells. Eur J Biochem. 1996 Feb 01; 235(3):480-5. PMID: 8654391.
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    205. Ackermann EJ, Dennis EA. Mammalian calcium-independent phospholipase A2. Biochim Biophys Acta. 1995 Nov 16; 1259(2):125-36. PMID: 7488632.
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    206. Balsinde J, Bianco ID, Ackermann EJ, Conde-Frieboes K, Dennis EA. Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8527-31. PMID: 7667324.
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    207. Carman GM, Deems RA, Dennis EA. Lipid signaling enzymes and surface dilution kinetics. J Biol Chem. 1995 Aug 11; 270(32):18711-4. PMID: 7642515.
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    208. Bianco ID, Kelley MJ, Crowl RM, Dennis EA. Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide. Biochim Biophys Acta. 1995 Jul 19; 1250(2):197-203. PMID: 7632725.
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    209. Balboa MA, Balsinde J, Dennis EA, Insel PA. A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells. J Biol Chem. 1995 May 19; 270(20):11738-40. PMID: 7538121.
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    210. Reynolds LJ, Kempner ES, Hughes LL, Dennis EA. Inactivation of secretory phospholipase A2 by ionizing radiation. Biophys J. 1995 May; 68(5):2108-14. PMID: 7612854.
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    211. Plesniak LA, Yu L, Dennis EA. Conformation of micellar phospholipid bound to the active site of phospholipase A2. Biochemistry. 1995 Apr 18; 34(15):4943-51. PMID: 7711016.
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    212. Ackermann EJ, Conde-Frieboes K, Dennis EA. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 06; 270(1):445-50. PMID: 7814408.
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    213. Dennis EA. Potential phospholipase A2s involved in inflammatory diseases. Agents Actions Suppl. 1995; 46:35-9. PMID: 7610989.
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    214. Dennis EA, Ackermann EJ, Deems RA, Reynolds LJ. Multiple forms of phospholipase A2 in macrophages capable of arachidonic acid release for eicosanoid biosynthesis. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:75-80. PMID: 7732908.
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    215. Asmis R, Dennis EA. Regulation of prostaglandin E2 production in P388D1 macrophage-like cells. Ann N Y Acad Sci. 1994 Nov 15; 744:1-10. PMID: 7825831.
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    216. Asmis R, Dennis EA. PAF stimulates cAMP formation in P388D1 macrophage-like cells via the formation and secretion of prostaglandin E2 in an autocrine fashion. Biochim Biophys Acta. 1994 Nov 10; 1224(2):295-301. PMID: 7981245.
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    217. Balsinde J, Barbour SE, Bianco ID, Dennis EA. Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):11060-4. PMID: 7972009.
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    218. Dennis EA. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 06; 269(18):13057-60. PMID: 8175726.
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    219. Ackermann EJ, Kempner ES, Dennis EA. Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization. J Biol Chem. 1994 Mar 25; 269(12):9227-33. PMID: 8132660.
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    220. Asmis R, Randriamampita C, Tsien RY, Dennis EA. Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells. Biochem J. 1994 Mar 15; 298 Pt 3:543-51. PMID: 8141766.
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    221. Reynolds LJ, Hughes LL, Yu L, Dennis EA. 1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A2. Anal Biochem. 1994 Feb 15; 217(1):25-32. PMID: 8203736.
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    222. Dennis EA, Krell RD. Summary: the enzymes, accessory proteins, and receptors of leukotriene metabolism and their inhibition and antagonism. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:63-7. PMID: 7771350.
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    223. Barbour SE, Dennis EA. Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells. J Biol Chem. 1993 Oct 15; 268(29):21875-82. PMID: 8408042.
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    224. Yu L, Dennis EA. Effect of polar head groups on the interactions of phospholipase A2 with phosphonate transition-state analogues. Biochemistry. 1993 Sep 28; 32(38):10185-92. PMID: 8399145.
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    225. Plesniak LA, Boegeman SC, Segelke BW, Dennis EA. Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. Biochemistry. 1993 May 18; 32(19):5009-16. PMID: 8494876.
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    226. Reynolds LJ, Hughes LL, Louis AI, Kramer RM, Dennis EA. Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2. Biochim Biophys Acta. 1993 Apr 23; 1167(3):272-80. PMID: 8481388.
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    227. Stafford RE, Zhang YY, Deems RA, Dennis EA. Kinetic analysis and substrate specificity of a lysophospholipase from the macrophage-like cell line P388D1. Biochim Biophys Acta. 1993 Mar 17; 1167(1):43-8. PMID: 8461331.
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    228. Fremont DH, Anderson DH, Wilson IA, Dennis EA, Xuong NH. Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):342-6. PMID: 8419939.
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    229. Davidson FF, Dennis EA. Limitations of phosphatidylcholine/deoxycholate mixtures for the analysis of phospholipase A2 inhibition and activation: illustration with annexins. Biochim Biophys Acta. 1992 Aug 19; 1127(3):270-6. PMID: 1387325.
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    230. Reynolds LJ, Hughes LL, Dennis EA. Analysis of human synovial fluid phospholipase A2 on short chain phosphatidylcholine-mixed micelles: development of a spectrophotometric assay suitable for a microtiterplate reader. Anal Biochem. 1992 Jul; 204(1):190-7. PMID: 1514686.
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    231. Kelley MJ, Crowl RM, Dennis EA. Renaturation of cobra venom phospholipase A2 expressed from a synthetic gene in Escherichia coli. Biochim Biophys Acta. 1992 Jan 09; 1118(2):107-15. PMID: 1730025.
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    232. Dennis EA. The biosynthesis of phospholipids. Methods Enzymol. 1992; 209:1-4. PMID: 1495408.
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    233. Dennis EA, Deems RA, Yu L. Extracellular phospholipase A2. Adv Exp Med Biol. 1992; 318:35-9. PMID: 1636503.
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    234. Yu L, Dennis EA. Critical role of a hydrogen bond in the interaction of phospholipase A2 with transition-state and substrate analogues. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):9325-9. PMID: 1924395.
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    235. Reynolds LJ, Mihelich ED, Dennis EA. Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation. J Biol Chem. 1991 Sep 05; 266(25):16512-7. PMID: 1885583.
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    236. Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991 Apr; 5(7):2068-77. PMID: 1901288.
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    237. Washburn WN, Dennis EA. Suicide-inhibitory bifunctionally linked substrates (SIBLINKS) as phospholipase A2 inhibitors. Mechanistic implications. J Biol Chem. 1991 Mar 15; 266(8):5042-8. PMID: 2002046.
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    238. Glaser KB, Asmis R, Dennis EA. PAF receptor mediated PGE2 production in LPS primed P388D1 macrophage-like cells. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:249-55. PMID: 1847769.
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    239. Stephens D, Dennis E, Toomer M, Holloway J. The diversity of case management needs for the care of homeless persons. Public Health Rep. 1991 Jan-Feb; 106(1):15-9. PMID: 1899934.
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    240. Zhang YY, Deems RA, Dennis EA. Lysophospholipases I and II from P388D1 macrophage-like cell line. Methods Enzymol. 1991; 197:456-68. PMID: 2051937.
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    241. Yu L, Dennis EA. Thio-based phospholipase assay. Methods Enzymol. 1991; 197:65-75. PMID: 2051946.
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    242. Kempner ES, Osborne JC, Reynolds LJ, Deems RA, Dennis EA. Analysis of lipases by radiation inactivation. Methods Enzymol. 1991; 197:280-8. PMID: 2051921.
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    243. Reynolds LJ, Dennis EA. Cobra venom phospholipase A2: Naja naja naja. Methods Enzymol. 1991; 197:359-65. PMID: 2051932.
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    244. Reynolds LJ, Washburn WN, Deems RA, Dennis EA. Assay strategies and methods for phospholipases. Methods Enzymol. 1991; 197:3-23. PMID: 2051923.
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    245. Davidson FF, Dennis EA. Evolutionary relationships and implications for the regulation of phospholipase A2 from snake venom to human secreted forms. J Mol Evol. 1990 Sep; 31(3):228-38. PMID: 2120459.
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    246. Glaser KB, Asmis R, Dennis EA. Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2. J Biol Chem. 1990 May 25; 265(15):8658-64. PMID: 2160463.
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    247. Davidson FF, Lister MD, Dennis EA. Binding and inhibition studies on lipocortins using phosphatidylcholine vesicles and phospholipase A2 from snake venom, pancreas, and a macrophage-like cell line. J Biol Chem. 1990 Apr 05; 265(10):5602-9. PMID: 2138608.
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    248. Yu L, Deems RA, Hajdu J, Dennis EA. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J Biol Chem. 1990 Feb 15; 265(5):2657-64. PMID: 2303420.
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    249. Davidson FF, Dennis EA. Amino acid sequence and circular dichroism of Indian cobra (Naja naja naja) venom acidic phospholipase A2. Biochim Biophys Acta. 1990 Jan 19; 1037(1):7-15. PMID: 2294972.
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    250. Glaser KB, Lister MD, Ulevitch RJ, Dennis EA. Macrophage phospholipase A2 activity and eicosanoid production: studies with phospholipase A2 inhibitors in P388D1 cells. Adv Exp Med Biol. 1990; 275:1-16. PMID: 2239440.
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    251. Dennis EA. Modification of the arachidonic acid cascade through phospholipase A2 dependent mechanisms. Adv Prostaglandin Thromboxane Leukot Res. 1990; 20:217-23. PMID: 2144695.
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    252. Hazlett TL, Deems RA, Dennis EA. Activation, aggregation, inhibition and the mechanism of phospholipase A2. Adv Exp Med Biol. 1990; 279:49-64. PMID: 2096700.
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    253. Dennis EA, Davidson FF. Phospholipase A2 and lipocortin effects. Prog Clin Biol Res. 1990; 349:47-54. PMID: 2144646.
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    254. Davidson FF, Dennis EA. Biological relevance of lipocortins and related proteins as inhibitors of phospholipase A2. Biochem Pharmacol. 1989 Nov 01; 38(21):3645-51. PMID: 2532012.
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    255. Fanni T, Deems RA, Dennis EA. 18O isotope exchange experiments on phospholipase A2 determined by 13C-NMR: monomeric phosphatidylcholine and micellar phosphatidylethanolamine substrates. Biochim Biophys Acta. 1989 Jul 17; 1004(1):134-8. PMID: 2742867.
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    256. Stafford RE, Fanni T, Dennis EA. Interfacial properties and critical micelle concentration of lysophospholipids. Biochemistry. 1989 Jun 13; 28(12):5113-20. PMID: 2669968.
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    257. Lister MD, Glaser KB, Ulevitch RJ, Dennis EA. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. J Biol Chem. 1989 May 25; 264(15):8520-8. PMID: 2498315.
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    258. Barlow PN, Lister MD, Sigler PB, Dennis EA. Probing the role of substrate conformation in phospholipase A2 action on aggregated phospholipids using constrained phosphatidylcholine analogues. J Biol Chem. 1988 Sep 15; 263(26):12954-8. PMID: 3417646.
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    259. Zhang YY, Dennis EA. Purification and characterization of a lysophospholipase from a macrophage-like cell line P388D1. J Biol Chem. 1988 Jul 15; 263(20):9965-72. PMID: 3384824.
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    260. Hazlett TL, Dennis EA. Lipid-induced aggregation of phospholipase A2: sucrose density gradient ultracentrifugation and crosslinking studies. Biochim Biophys Acta. 1988 Jul 01; 961(1):22-9. PMID: 3382690.
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    261. Lister MD, Deems RA, Watanabe Y, Ulevitch RJ, Dennis EA. Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid. J Biol Chem. 1988 Jun 05; 263(16):7506-13. PMID: 3131322.
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    262. Ulevitch RJ, Watanabe Y, Sano M, Lister MD, Deems RA, Dennis EA. Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line. J Biol Chem. 1988 Mar 05; 263(7):3079-85. PMID: 3343241.
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    263. Hazlett TL, Dennis EA. Effect of phospholipids on fluorescence polarization and lifetimes of fluorescein-labeled phospholipase A2. Biochim Biophys Acta. 1988 Feb 04; 958(2):172-8. PMID: 3337833.
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    264. Deems RA, Lombardo D, Morgan BP, Mihelich ED, Dennis EA. The inhibition of phospholipase A2 by manoalide and manoalide analogues. Biochim Biophys Acta. 1987 Feb 14; 917(2):258-68. PMID: 3801502.
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    265. Davidson FF, Dennis EA, Powell M, Glenney JR. Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids. J Biol Chem. 1987 Feb 05; 262(4):1698-705. PMID: 2948959.
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    266. Dennis EA. Micellization and solubilization of phospholipids by surfactants. Adv Colloid Interface Sci. 1986 Nov; 26(2-4):155-75. PMID: 3333134.
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    267. Lombardo D, Fanni T, Plückthun A, Dennis EA. Rate-determining step in phospholipase A2 mechanism. 18O isotope exchange determined by 13C NMR. J Biol Chem. 1986 Sep 05; 261(25):11663-6. PMID: 3745162.
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    268. Davidson FF, Hajdu J, Dennis EA. 1-Stearyl,2-stearoylaminodeoxy phosphatidylcholine, a potent reversible inhibitor of phospholipase A2. Biochem Biophys Res Commun. 1986 Jun 13; 137(2):587-92. PMID: 3755338.
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    269. Plückthun A, DeBony J, Fanni T, Dennis EA. Conformation of fatty acyl chains in alpha- and beta-phosphatidylcholine and phosphatidylethanolamine derivatives in sonicated vesicles. Biochim Biophys Acta. 1986 Mar 27; 856(1):144-54. PMID: 3955032.
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    270. Lombardo D, Dennis EA. Immobilized phospholipase A2 from cobra venom. Prevention of substrate interfacial and activator effects. J Biol Chem. 1985 Dec 25; 260(30):16114-21. PMID: 4066705.
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    271. Dennis E, Berg P. Transcription from a plant gene promoter in animal cells. Nucleic Acids Res. 1985 Nov 25; 13(22):7945-57. PMID: 2866489.
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    272. Hazlett TL, Dennis EA. Aggregation studies on fluorescein-coupled cobra venom phospholipase A2. Biochemistry. 1985 Oct 22; 24(22):6152-8. PMID: 3936540.
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    273. Plückthun A, Dennis EA. Activation, aggregation, and product inhibition of cobra venom phospholipase A2 and comparison with other phospholipases. J Biol Chem. 1985 Sep 15; 260(20):11099-106. PMID: 4030786.
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    274. Plückthun A, Rohlfs R, Davidson FF, Dennis EA. Short-chain phosphatidylethanolamines: physical properties and susceptibility of the monomers to phospholipase A2 action. Biochemistry. 1985 Jul 16; 24(15):4201-8. PMID: 4052390.
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    275. Lombardo D, Dennis EA. Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. J Biol Chem. 1985 Jun 25; 260(12):7234-40. PMID: 3997864.
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    276. Ross MI, Deems RA, Jesaitis AJ, Dennis EA, Ulevitch RJ. Phospholipase activities of the P388D1 macrophage-like cell line. Arch Biochem Biophys. 1985 Apr; 238(1):247-58. PMID: 3985620.
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    277. Kensil CR, Dennis EA. Action of cobra venom phospholipase A2 on large unilamellar vesicles: comparison with small unilamellar vesicles and multibilayers. Lipids. 1985 Feb; 20(2):80-3. PMID: 3838567.
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    278. Hazlett TL, Dennis EA. Affinity chromatography of phospholipase A2 from Naja naja naja (Indian cobra) venom. Toxicon. 1985; 23(3):457-66. PMID: 3927524.
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    279. Jarvis AA, Cain C, Dennis EA. Purification and characterization of a lysophospholipase from human amnionic membranes. J Biol Chem. 1984 Dec 25; 259(24):15188-95. PMID: 6511790.
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    280. Hendrickson HS, Dennis EA. Analysis of the kinetics of phospholipid activation of cobra venom phospholipase A2. J Biol Chem. 1984 May 10; 259(9):5740-4. PMID: 6715371.
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    281. Hendrickson HS, Dennis EA. Kinetic analysis of the dual phospholipid model for phospholipase A2 action. J Biol Chem. 1984 May 10; 259(9):5734-9. PMID: 6715370.
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    282. Lichtenberg D, Robson RJ, Dennis EA. Solubilization of phospholipids by detergents. Structural and kinetic aspects. Biochim Biophys Acta. 1983 May 24; 737(2):285-304. PMID: 6342675.
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    283. Vogel CW, Plückthun A, Podack ER, Dennis EA, Müller-Eberhard HJ. The membrane attack complex of complement and its precursor proteins lack phospholipase activity. Mol Immunol. 1983 Apr; 20(4):377-82. PMID: 6865955.
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    284. Plückthun A, Dennis EA. Role of monomeric activators in cobra venom phospholipase A2 action. Biochemistry. 1982 Apr 13; 21(8):1750-6. PMID: 7082644.
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    285. Plückthun A, Dennis EA. Acyl and phosphoryl migration in lysophospholipids: importance in phospholipid synthesis and phospholipase specificity. Biochemistry. 1982 Apr 13; 21(8):1743-50. PMID: 7082643.
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    286. Adamich M, Dennis EA. Phospholipase a(2) action on membrane surfaces: effect of ionic strength, triton x-100, and melittin. Biophys J. 1982 Jan; 37(1):166-8. PMID: 19431460.
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    287. Vogel CW, Plückthun A, Müller-Eberhard HJ, Dennis EA. Hemolytic assay for venom phospholipase A2. Anal Biochem. 1981 Dec; 118(2):262-8. PMID: 7337224.
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    288. Kensil CR, Dennis EA. Alkaline hydrolysis of phospholipids in model membranes and the dependence on their state of aggregation. Biochemistry. 1981 Oct 13; 20(21):6079-85. PMID: 7197987.
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    289. De Bony J, Dennis EA. Magnetic nonequivalence of the two fatty acid chains in phospholipids of small unilamellar vesicles and mixed micelles. Biochemistry. 1981 Sep 01; 20(18):5256-60. PMID: 7197548.
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    290. Dennis EA, Darke PL, Deems RA, Kensil CR, Plückthun A. Cobra venom phospholipase A2: a review of its action toward lipid/water interfaces. Mol Cell Biochem. 1981 Apr 13; 36(1):37-45. PMID: 7242529.
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    291. Deems RA, Dennis EA. Phospholipase A2 from cobra venom (Naja naja naja). Methods Enzymol. 1981; 71 Pt C:703-10. PMID: 7278679.
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    292. Darke PL, Jarvis AA, Deems RA, Dennis EA. Further characterization and N-terminal sequence of cobra venom phospholipase A2. Biochim Biophys Acta. 1980 Nov 20; 626(1):154-61. PMID: 7459378.
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    293. Barden RE, Darke PL, Deems RA, Dennis EA. Interaction of phospholipase A2 from cobra venom with Cibacron Blue F3GA. Biochemistry. 1980 Apr 15; 19(8):1621-5. PMID: 7378369.
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    294. Roberts MF, Adamich M, Robson RJ, Dennis EA. Phospholipid activation of cobra venom phospholipase A2. 1. Lipid--lipid or lipid--enzyme interaction. Biochemistry. 1979 Jul 24; 18(15):3301-8. PMID: 465468.
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    295. Adamich M, Roberts MF, Dennis EA. Phospholipid activation of cobra venom phospholipase A2. 2. Characterization of the phospholipid--enzyme interaction. Biochemistry. 1979 Jul 24; 18(15):3308-14. PMID: 465469.
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    296. Kensil CR, Dennis EA. Action of cobra venom phospholipase A2 on the gel and liquid crystalline states of dimyristoyl and dipalmitoyl phosphatidylcholine vesicles. J Biol Chem. 1979 Jul 10; 254(13):5843-8. PMID: 582173.
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    297. Robson RJ, Dennis EA. Mixed micelles of sphingomyelin and phosphatidylcholine with nonionic surfactants. Effect of temperature and surfactant polydispersity. Biochim Biophys Acta. 1979 Jun 21; 573(3):489-500. PMID: 465516.
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    298. Adamich M, Dennis EA. Action of cobra venom phospholipase A2 toward lipids of erythrocyte membranes. Prog Clin Biol Res. 1979; 30:515-21. PMID: 531042.
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    299. Adamich M, Voss HF, Dennis EA. Cobra venom phospholipase A2 immobilized to porocus glass beads. Arch Biochem Biophys. 1978 Aug; 189(2):417-23. PMID: 30410.
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    300. Adamich M, Dennis EA. Exploring the action and specificity of cobra venom phospholipase A2 toward human erythrocytes, ghost membranes, and lipid mixtures. J Biol Chem. 1978 Jul 25; 253(14):5121-5. PMID: 670181.
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    301. Shaw JO, Roberts MF, Ulevitch RJ, Henson P, Dennis EA. Phospholipase A2 contamination of cobra venom factor preparations. Biologic role in complement-dependent in vivo reactions and inactivation with p-bromophenacyl bromide. Am J Pathol. 1978 Jun; 91(3):517-30. PMID: 655262.
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    302. Robson RJ, Dennis EA. Characterization of mixed micelles of phospholipids of various classes and a synthetic, homogeneous analogue of the nonionic detergent Triton X-100 containing nine oxyethylene groups. Biochim Biophys Acta. 1978 Apr 20; 508(3):513-24. PMID: 638153.
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    303. Roberts MF, Bothner-By AA, Dennis EA. Magnetic nonequivalence within fatty acyl chains of phospholipids in membrane models: 1H nuclear magnetic resonance studies of the alpha-methylene groups. Biochemistry. 1978 Mar 07; 17(5):935-42. PMID: 580222.
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    304. Roberts MF, Otnaess AB, Kensil CA, Dennis EA. The specificity of phospholipase A2 and phospholipase C in a mixed micellar system. J Biol Chem. 1978 Feb 25; 253(4):1252-7. PMID: 624729.
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    305. Adamich M, Dennis EA. Specificity reversal in phospholipase A2 hydrolysis of lipid mixtures. Biochem Biophys Res Commun. 1978 Jan 30; 80(2):424-8. PMID: 623670.
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    306. Dennis EA. Mechanism of phospholipase A2 action toward mixed micelles of detergent and phospholipids. Adv Exp Med Biol. 1978; 101:165-75. PMID: 665362.
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    307. Lewis RV, Roberts MF, Dennis EA, Allison WS. Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2. Biochemistry. 1977 Dec 13; 16(25):5650-4. PMID: 921957.
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    308. Roberts MF, Deems RA, Dennis EA. Spectral perturbations of the histidine and tryptophan in cobra venom phospholipase A2 upon metal ion and mixed micelle binding. J Biol Chem. 1977 Sep 10; 252(17):6011-7. PMID: 19461.
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    309. Roberts MF, Dennis EA. Proton nuclear magnetic resonance demonstration of conformationally nonequivalent phospholipid fatty acid chains in mixed micelles. J Am Chem Soc. 1977 Aug 31; 99(18):6142-3. PMID: 893884.
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    310. Roberts MF, Deems RA, Dennis EA. Dual role of interfacial phospholipid in phospholipase A2 catalysis. Proc Natl Acad Sci U S A. 1977 May; 74(5):1950-4. PMID: 266715.
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    311. Roberts MF, Deems RA, Mincey TC, Dennis EA. Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity. J Biol Chem. 1977 Apr 10; 252(7):2405-11. PMID: 14964.
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    312. Eaton BR, Dennis EA. Analysis of phospholipase C (Bacillus cereus) action toward mixed micelles of phospholipid and surfactant. Arch Biochem Biophys. 1976 Oct; 176(2):604-9. PMID: 10851.
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    313. Deems RA, Dennis EA. Characterization and physical properties of the major form of phospholipase A2 from cobra venom (Naja naja naja) that has a molecular weight of 11,000. J Biol Chem. 1975 Dec 10; 250(23):9008-12. PMID: 1194273.
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    314. Deems RA, Eaton BR, Dennis EA. Kinetic analysis of phospholipase A2 activity toward mixed micelles and its implications for the study of lipolytic enzymes. J Biol Chem. 1975 Dec 10; 250(23):9013-20. PMID: 1194274.
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    315. Warner TG, Dennis EA. Action of the highly purified, membrane-bound enzyme phosphatidylserine decarboxylase Escherichia coli toward phosphatidylserine in mixed micelles and erythrocyte ghosts in the presence of surfactant. J Biol Chem. 1975 Oct 25; 250(20):8004-9. PMID: 1100627.
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    316. Ribeiro AA, Dennis EA. Proton magnetic resonance relaxation studies on the structure of mixed micelles of Triton X-100 and dimyristoylphosphatidylcholine. Biochemistry. 1975 Aug 26; 14(17):3746-55. PMID: 1174502.
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    317. Ribeiro AA, Dennis EA. PMR relaxation times of micelles of the nonionic surfactant Triton X-100 and mixed micelles with phospholipids. Chem Phys Lipids. 1975 Apr; 14(2):193-9. PMID: 1168549.
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    318. Warner TG, Dennis EA. Phosphatidylserine decarboxylase: analysis of its action towards unsaturated and saturated phosphatidylserine and the effect of Triton X-100 on activity. Arch Biochem Biophys. 1975 Apr; 167(2):761-8. PMID: 235903.
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    319. Dennis EA. Formation and characterization of mixed micelles of the nonionic surfactant Triton X-100 with egg, dipalmitoyl, and dimyristoyl phosphatidylcholines. Arch Biochem Biophys. 1974 Dec; 165(2):764-73. PMID: 4474840.
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    320. Dennis EA. Interaction of enzymes with mixed micelles of phospholipid and detergent: analysis of the phospholipase A2--dipalmitoyl phosphadidycholine--Triton X 100 system. J Supramol Struct. 1974; 2(5-6):682-94. PMID: 4461851.
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    321. Dennis EA. Phospholipase A2 activity towards phosphatidylcholine in mixed micelles: surface dilution kinetics and the effect of thermotropic phase transitions. Arch Biochem Biophys. 1973 Oct; 158(2):485-93. PMID: 4798723.
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    322. Warner TG, Dennis EA. New sensitive assay for phosphatidylserine decarboxylase based on the detection of CO2 from nonradiolabeled phosphatidylserine. J Lipid Res. 1973 Sep; 14(5):595-8. PMID: 4199724.
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    323. Dennis EA. Kinetic dependence of phospholipase A 2 activity on the detergent Triton X-100. J Lipid Res. 1973 Mar; 14(2):152-9. PMID: 4698263.
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    324. Dennis EA, Owens JM. Studies on mixed micelles of Triton X-100 and phosphatidylcholine using nuclear magnetic resonance techniques. J Supramol Struct. 1973; 1(3):165-76. PMID: 4807574.
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    325. Dennis EA, Kennedy EP. Intracellular sites of lipid synthesis and the biogenesis of mitochondria. J Lipid Res. 1972 Mar; 13(2):263-7. PMID: 5016308.
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    326. Dennis EA, Kennedy EP. Enzymatic synthesis and decarboxylation of phosphatidylserine in Tetrahymena pyriformis. J Lipid Res. 1970 Sep; 11(5):394-403. PMID: 5501474.
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    327. Roberts GC, Dennis EA, Meadows DH, Cohen JS, Jardetzky O. The mechanism of action of ribonuclease. Proc Natl Acad Sci U S A. 1969 Apr; 62(4):1151-8. PMID: 5256413.
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    328. Dennis EA, Westheimer FH. The rates of hydrolysis of esters of cyclic phosphinic acids. J Am Chem Soc. 1966 Jul 20; 88(14):3431. PMID: 5946602.
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    329. Dennis EA, Westheimer FH. The geometry of the transition state in the hydrolysis of phosphate esters. J Am Chem Soc. 1966 Jul 20; 88(14):3432-3. PMID: 5946603.
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    330. HEIDER C, DENNIS E. Chlorothiazide potentiation of ganglionic blockade in patients with hypertension. Ann N Y Acad Sci. 1958 Feb 03; 71(4):456-64. PMID: 13583801.
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    331. DENNIS E, FORD R, HERSCHBERGER R, MOYER JH. Pentolinium and hexamethonium combined with Rauwolfia in the treatment of hypertension. N Engl J Med. 1955 Oct 06; 253(14):597-600. PMID: 13266002.
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