Edward Dennis

Title(s)Professor, Pharmacology
SchoolAcademic Aff
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    Collapse Research 
    Collapse Research Activities and Funding
    NIH/NIDDK R01DK105961Aug 26, 2015 - May 31, 2019
    Role: Principal Investigator
    Impact of Lipidomics Conference Series
    NIH/NIGMS R13GM106571Feb 15, 2014 - Jan 31, 2017
    Role: Principal Investigator
    NIH/NIGMS U54GM069338Aug 12, 2003 - Jul 31, 2014
    Role: Principal Investigator
    Lipid Maps
    NIH/NIGMS R24GM067877Sep 30, 2002 - Sep 30, 2003
    Role: Principal Investigator
    Regulation of Lipid Mediators in Spinal Microglia and Astrocytes
    NIH/NIGMS R01GM064611Sep 17, 2002 - Jan 31, 2013
    Role: Principal Investigator
    NIH/NIGMS R01GM051606Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    NIH/NIGMS R13GM047924Jun 1, 1992 - May 31, 1993
    Role: Principal Investigator
    NIH/NICHD R01HD026171Sep 1, 1989 - Dec 31, 2000
    Role: Principal Investigator
    NIH/NIDDK R13DK041231Jul 1, 1989 - May 31, 1990
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Action of Lipolytic Enzymes
    NIH/NIGMS R01GM020501Jun 1, 1977 - Dec 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Declèves AE, Mathew AV, Armando AM, Han X, Dennis EA, Quehenberger O, Sharma K. AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. J Lipid Res. 2019 Mar 12. PMID: 30862696.
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    2. Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G. ß-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit ß-Cell Apoptosis. J Med Chem. 2019 Mar 12. PMID: 30798607.
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    3. Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 Jan 11. PMID: 30661990.
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    4. O'Donnell VB, Dennis EA, Wakelam MJO, Subramaniam S. LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training. Sci Signal. 2019 Jan 08; 12(563). PMID: 30622195.
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    5. Mouchlis VD, Armando A, Dennis EA. Substrate specific inhibition constants for phospholipase A2 acting on unique phospholipid substrates in mixed micelles and membranes using lipidomics. J Med Chem. 2019 Jan 07. PMID: 30615445.
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    6. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. PMID: 30130298.
      View in: PubMed
    7. Quehenberger O, Dahlberg-Wright S, Jiang J, Armando AM, Dennis EA. Quantitative determination of esterified eicosanoids and related oxygenated metabolites after base hydrolysis. J Lipid Res. 2018 Dec; 59(12):2436-2445. PMID: 30323111.
      View in: PubMed
    8. Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešic M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR. MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. J Lipid Res. 2018 Oct; 59(10):2001-2017. PMID: 30115755.
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    9. Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2). ACS Omega. 2018 Aug 31; 3(8):8843-8853. PMID: 30197994.
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    10. Mouchlis VD, Chen Y, McCammon JA, Dennis EA. Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity. J Am Chem Soc. 2018 03 07; 140(9):3285-3291. PMID: 29342349.
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    11. Navratil AR, Shchepinov MS, Dennis EA. Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo. J Am Chem Soc. 2018 01 10; 140(1):235-243. PMID: 29206462.
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    12. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. PMID: 29404441.
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    13. Vasquez AM, Mouchlis VD, Dennis EA. Review of four major distinct types of human phospholipase A2. Adv Biol Regul. 2018 Jan; 67:212-218. PMID: 29248300.
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    14. Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S. Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res. 2017 12; 58(12):2275-2288. PMID: 28986437.
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    15. Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, Kokotos G. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Sci Rep. 2017 Aug 01; 7(1):7025. PMID: 28765606.
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    16. Brown CR, Dennis EA. Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis. Biochimie. 2017 Oct; 141:86-90. PMID: 28630010.
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    17. Smyrniotou A, Kokotou MG, Mouchlis VD, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V. 2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors. Bioorg Med Chem. 2017 02 01; 25(3):926-940. PMID: 28034646.
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    18. Sokolowska M, Chen LY, Liu Y, Martinez-Anton A, Logun C, Alsaaty S, Cuento RA, Cai R, Sun J, Quehenberger O, Armando AM, Dennis EA, Levine SJ, Shelhamer JH. Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma. J Allergy Clin Immunol. 2017 04; 139(4):1379-1383. PMID: 27826094.
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    19. Dennis EA. Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease. J Biol Chem. 2016 Nov 18; 291(47):24431-24448. PMID: 27555328.
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    20. Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorg Med Chem. 2016 10 01; 24(19):4544-4554. PMID: 27522578; PMCID: PMC5014611 [Available on 10/01/17].
    21. Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 10 15; 24(20):4801-4811. PMID: 27320659.
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    22. Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships. J Med Chem. 2016 05 12; 59(9):4403-14. PMID: 27087127; PMCID: PMC4946799 [Available on 05/12/17].
    23. Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S. Computational Modeling of Competitive Metabolism between ?3- and ?6-Polyunsaturated Fatty Acids in Inflammatory Macrophages. J Phys Chem B. 2016 08 25; 120(33):8346-53. PMID: 27063350.
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    24. Mouchlis VD, Dennis EA. Membrane and inhibitor interactions of intracellular phospholipases A2. Adv Biol Regul. 2016 05; 61:17-24. PMID: 26774606; PMCID: PMC4884535 [Available on 05/01/17].
    25. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug; 15(8):511-23. PMID: 26139350; PMCID: PMC4606863.
    26. Dennis EA. Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease. J Lipid Res. 2015 Jul; 56(7):1245-7. PMID: 26031662.
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    27. Mouchlis VD, Bucher D, McCammon JA, Dennis EA. Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E516-25. PMID: 25624474; PMCID: PMC4330758.
    28. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-36. PMID: 25598080; PMCID: PMC4340319.
    29. Astarita G, Kendall AC, Dennis EA, Nicolaou A. Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids. Biochim Biophys Acta. 2015 Apr; 1851(4):456-68. PMID: 25486530; PMCID: PMC4323855.
    30. Loomba R, Quehenberger O, Armando A, Dennis EA. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res. 2015 Jan; 56(1):185-92. PMID: 25404585; PMCID: PMC4274066.
    31. Baker PR, Armando AM, Campbell JL, Quehenberger O, Dennis EA. Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies. J Lipid Res. 2014 Nov; 55(11):2432-42. PMID: 25225680; PMCID: PMC4617145.
    32. Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25; 57(18):7523-35. PMID: 25152071.
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    33. Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA. Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12746-51. PMID: 25139986; PMCID: PMC4156727.
    34. Jiao J, Ishikawa TO, Dumlao DS, Norris PC, Magyar CE, Mikulec C, Catapang A, Dennis EA, Fischer SM, Herschman HR. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res. 2014 Nov; 12(11):1677-88. PMID: 25063587; PMCID: PMC4233191.
    35. Wang Y, Armando AM, Quehenberger O, Yan C, Dennis EA. Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples. J Chromatogr A. 2014 Sep 12; 1359:60-9. PMID: 25074422; PMCID: PMC4592635.
    36. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. PMID: 24613321; PMCID: PMC4629781.
    37. Kihara Y, Gupta S, Maurya MR, Armando A, Shah I, Quehenberger O, Glass CK, Dennis EA, Subramaniam S. Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophys J. 2014 Feb 18; 106(4):966-75. PMID: 24559999; PMCID: PMC3945033.
    38. Jiao J, Mikulec C, Ishikawa TO, Magyar C, Dumlao DS, Dennis EA, Fischer SM, Herschman H. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. 2014 Jun; 35(6):1310-9. PMID: 24469308; PMCID: PMC4043244.
    39. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145. PMID: 24376657.
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    40. Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13; 288(50):35812-23. PMID: 24189069; PMCID: PMC3861632.
    41. Kennelly PJ, Bond JS, Masters BS, Dennis EA, Brenner C, Raben DM. Desperately seeking Flexner: time to reemphasize basic science in medical education. Acad Med. 2013 Oct; 88(10):1405-6. PMID: 24064614.
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    42. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-214. PMID: 24074869; PMCID: PMC4131699.
    43. Norris PC, Dennis EA. A lipidomic perspective on inflammatory macrophage eicosanoid signaling. Adv Biol Regul. 2014 Jan; 54:99-110. PMID: 24113376; PMCID: PMC3946543.
    44. Merrill AH, Dennis EA, McDonald JG, Fahy E. Lipidomics technologies at the end of the first decade and the beginning of the next. Adv Nutr. 2013 Sep 01; 4(5):565-7. PMID: 24038259; PMCID: PMC3771151.
    45. Bucher D, Hsu YH, Mouchlis VD, Dennis EA, McCammon JA. Insertion of the Ca²?-independent phospholipase A2 into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations. PLoS Comput Biol. 2013; 9(7):e1003156. PMID: 23935474; PMCID: PMC3723492.
    46. Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15; 21(18):5823-9. PMID: 23916152; PMCID: PMC3883354.
    47. Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum JL, Koschinsky ML, Tsimikas S. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res. 2013 Oct; 54(10):2815-30. PMID: 23828779; PMCID: PMC3770094.
    48. Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A. Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell. 2013 Jul 03; 154(1):213-27. PMID: 23827684; PMCID: PMC3753192.
    49. Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res. 2013 Sep; 54(9):2525-42. PMID: 23776196; PMCID: PMC3735949.
    50. Hsu YH, Dumlao DS, Cao J, Dennis EA. Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. PLoS One. 2013; 8(3):e59267. PMID: 23533611; PMCID: PMC3606342.
    51. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May; 27(5):1939-49. PMID: 23382512; PMCID: PMC3633813.
    52. Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL, McCammon JA, Dennis EA. Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics. J Am Chem Soc. 2013 Jan 30; 135(4):1330-7. PMID: 23256506; PMCID: PMC3561773.
    53. Cao J, Burke JE, Dennis EA. Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem. 2013 Jan 18; 288(3):1806-13. PMID: 23209293; PMCID: PMC3548490.
    54. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. J Lipid Res. 2013 Jan; 54(1):127-33. PMID: 23089916.
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    55. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28; 151(1):138-52. PMID: 23021221; PMCID: PMC3464914.
    56. van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. J Lipid Res. 2012 Dec; 53(12):2773-90. PMID: 22969153; PMCID: PMC3494262.
    57. Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao JL, Dennis EA, Moise AR. Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. J Biol Chem. 2012 Oct 12; 287(42):35260-74. PMID: 22923616; PMCID: PMC3471684.
    58. Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hanks JH, Halpin R, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR. Dietary fish oil substitution alters the eicosanoid profile in ankle joints of mice during Lyme infection. J Nutr. 2012 Aug; 142(8):1582-9. PMID: 22695969; PMCID: PMC3397342.
    59. Norris PC, Dennis EA. Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8517-22. PMID: 22586114; PMCID: PMC3365225.
    60. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6721-6. PMID: 22493235; PMCID: PMC3340022.
    61. Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA. The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6036-41. PMID: 22492977; PMCID: PMC3341022.
    62. Sabidó E, Quehenberger O, Shen Q, Chang CY, Shah I, Armando AM, Andreyev A, Vitek O, Dennis EA, Aebersold R. Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism. Mol Cell Proteomics. 2012 Jul; 11(7):M111.014746. PMID: 22361236; PMCID: PMC3394947.
    63. Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics. J Chem Inf Model. 2012 Jan 23; 52(1):243-54. PMID: 22196172.
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    64. Sud M, Fahy E, Cotter D, Dennis EA, Subramaniam S. LIPID MAPS-Nature Lipidomics Gateway: An Online Resource for Students and Educators Interested in Lipids. J Chem Educ. 2012 Jan 10; 89(2):291-292. PMID: 24764601.
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    65. Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K. Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. J Biol Chem. 2012 Mar 30; 287(14):11469-80. PMID: 22199362; PMCID: PMC3322886.
    66. Quehenberger O, Dennis EA. The human plasma lipidome. N Engl J Med. 2011 Nov 10; 365(19):1812-23. PMID: 22070478; PMCID: PMC3412394.
    67. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011 Dec; 152(12):2881-91. PMID: 22019135; PMCID: PMC3347973.
    68. Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev. 2011 Oct 12; 111(10):6130-85. PMID: 21910409.
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    69. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. FASEB J. 2011 Dec; 25(12):4240-52. PMID: 21868473; PMCID: PMC3236632.
    70. Quehenberger O, Armando AM, Dennis EA. High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry. Biochim Biophys Acta. 2011 Nov; 1811(11):648-56. PMID: 21787881; PMCID: PMC3205314.
    71. Dumlao DS, Buczynski MW, Norris PC, Harkewicz R, Dennis EA. High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines. Biochim Biophys Acta. 2011 Nov; 1811(11):724-36. PMID: 21689782; PMCID: PMC3205334.
    72. Norris PC, Reichart D, Dumlao DS, Glass CK, Dennis EA. Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. J Leukoc Biol. 2011 Sep; 90(3):563-74. PMID: 21653236; PMCID: PMC3157897.
    73. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic a-helix. Biochemistry. 2011 Jun 14; 50(23):5314-21. PMID: 21553808.
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    74. Quehenberger O, Yamashita T, Armando AM, Dennis EA, Palinski W. Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol. 2011 Aug; 205(2):156.e15-25. PMID: 21621186; PMCID: PMC3175501.
    75. Harkewicz R, Dennis EA. Applications of mass spectrometry to lipids and membranes. Annu Rev Biochem. 2011; 80:301-25. PMID: 21469951; PMCID: PMC3410560.
    76. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17; 285(51):39976-85. PMID: 20923771; PMCID: PMC3000979.
    77. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. PMID: 20710028; PMCID: PMC2952235.
    78. Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res. 2010 Nov; 51(11):3299-305. PMID: 20671299; PMCID: PMC2952570.
    79. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA. Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res. 2010 Sep; 51(9):2785-97. PMID: 20574076; PMCID: PMC2918461.
    80. Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem. 2010 Aug; 114(4):981-93. PMID: 20492349; PMCID: PMC3994888.
    81. Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13; 53(9):3602-10. PMID: 20369880; PMCID: PMC2865582.
    82. Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med. 2010 Mar; 16(3):313-8. PMID: 20154695; PMCID: PMC2834836.
    83. Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. Application of proteomic marker ensembles to subcellular organelle identification. Mol Cell Proteomics. 2010 Feb; 9(2):388-402. PMID: 19884172; PMCID: PMC2830848.
    84. Blaho VA, Buczynski MW, Dennis EA, Brown CR. Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. J Immunol. 2009 Nov 01; 183(9):5644-53. PMID: 19843949; PMCID: PMC2857380.
    85. Hsu YH, Burke JE, Li S, Woods VL, Dennis EA. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009 Aug 28; 284(35):23652-61. PMID: 19556238; PMCID: PMC2749140.
    86. Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL, McCammon JA, Dennis EA. Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. J Am Chem Soc. 2009 Jun 17; 131(23):8083-91. PMID: 19459633.
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    87. Gupta S, Maurya MR, Stephens DL, Dennis EA, Subramaniam S. An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis. Biophys J. 2009 Jun 03; 96(11):4542-51. PMID: 19486676; PMCID: PMC2711499.
    88. Blaho VA, Buczynski MW, Brown CR, Dennis EA. Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. J Biol Chem. 2009 Aug 07; 284(32):21599-612. PMID: 19487688; PMCID: PMC2755884.
    89. Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 01; 17(13):4833-43. PMID: 19443224; PMCID: PMC2695835.
    90. Dennis EA, Witztum JL. Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1. PMID: 19346336; PMCID: PMC2674715.
    91. Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res. 2009 Jun; 50(6):1015-38. PMID: 19244215; PMCID: PMC2681385.
    92. Grkovich A, Armando A, Quehenberger O, Dennis EA. TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent. Biochim Biophys Acta. 2009 Oct; 1791(10):975-82. PMID: 19230851; PMCID: PMC2743746.
    93. Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G, David S. Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain. 2009 May; 132(Pt 5):1221-35. PMID: 19218359; PMCID: PMC2677793.
    94. Dennis EA. Lipidomics joins the omics evolution. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2089-90. PMID: 19211786; PMCID: PMC2650110.
    95. Grkovich A, Dennis EA. Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling. Adv Enzyme Regul. 2009; 49(1):114-20. PMID: 19534028; PMCID: PMC2888714.
    96. Dennis EA. Founding, early history, and transformation of the Journal for Lipid Research to an American Society of Biochemistry and Molecular Biology journal. J Lipid Res. 2009 Apr; 50 Suppl:S3-8. PMID: 19116414; PMCID: PMC2674755.
    97. Baskakis C, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25; 51(24):8027-37. PMID: 19053783; PMCID: PMC2649009.
    98. Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res. 2009 Apr; 50 Suppl:S9-14. PMID: 19098281; PMCID: PMC2674711.
    99. Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res. 2009 Apr; 50 Suppl:S237-42. PMID: 19011112; PMCID: PMC2674709.
    100. Quehenberger O, Armando A, Dumlao D, Stephens DL, Dennis EA. Lipidomics analysis of essential fatty acids in macrophages. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov; 79(3-5):123-9. PMID: 18996688; PMCID: PMC2643973.
    101. Antonopoulou G, Barbayianni E, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15; 16(24):10257-69. PMID: 18993078; PMCID: PMC2796434.
    102. Burke JE, Dennis EA. Phospholipase A2 biochemistry. Cardiovasc Drugs Ther. 2009 Feb; 23(1):49-59. PMID: 18931897; PMCID: PMC2823292.
    103. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. PMID: 18840708; PMCID: PMC2615656.
    104. Antonopoulou G, Magrioti V, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2. J Pept Sci. 2008 Oct; 14(10):1111-20. PMID: 18618424; PMCID: PMC2678953.
    105. Jacobsen FE, Buczynski MW, Dennis EA, Cohen SM. A macrophage cell model for selective metalloproteinase inhibitor design. Chembiochem. 2008 Sep 01; 9(13):2087-95. PMID: 18666306; PMCID: PMC2826882.
    106. Burke JE, Hsu YH, Deems RA, Li S, Woods VL, Dennis EA. A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem. 2008 Nov 07; 283(45):31227-36. PMID: 18753135; PMCID: PMC2576534.
    107. López-Vales R, Navarro X, Shimizu T, Baskakis C, Kokotos G, Constantinou-Kokotou V, Stephens D, Dennis EA, David S. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct; 131(Pt 10):2620-31. PMID: 18718965; PMCID: PMC2860706.
    108. Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry. 2008 Jun 17; 47(24):6451-9. PMID: 18500818; PMCID: PMC2459553.
    109. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. PMID: 18263582; PMCID: PMC2447632.
    110. Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL, Dennis EA. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2008 Apr 11; 283(15):9820-7. PMID: 18211893; PMCID: PMC2442293.
    111. Moutevelis-Minakakis P, Neokosmidi A, Filippakou M, Stephens D, Dennis EA, Kokotos G. Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2. J Pept Sci. 2007 Oct; 13(10):634-41. PMID: 17631670.
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    112. Six DA, Barbayianni E, Loukas V, Constantinou-Kokotou V, Hadjipavlou-Litina D, Stephens D, Wong AC, Magrioti V, Moutevelis-Minakakis P, Baker SF, Dennis EA, Kokotos G. Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2. J Med Chem. 2007 Aug 23; 50(17):4222-35. PMID: 17672443.
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    113. Buczynski MW, Stephens DL, Bowers-Gentry RC, Grkovich A, Deems RA, Dennis EA. TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells. J Biol Chem. 2007 Aug 03; 282(31):22834-47. PMID: 17535806.
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    114. Deems R, Buczynski MW, Bowers-Gentry R, Harkewicz R, Dennis EA. Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry. Methods Enzymol. 2007; 432:59-82. PMID: 17954213.
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    115. Schmelzer K, Fahy E, Subramaniam S, Dennis EA. The lipid maps initiative in lipidomics. Methods Enzymol. 2007; 432:171-83. PMID: 17954217.
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    116. Harkewicz R, Fahy E, Andreyev A, Dennis EA. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. J Biol Chem. 2007 Feb 02; 282(5):2899-910. PMID: 17135246.
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    117. Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. LMSD: LIPID MAPS structure database. Nucleic Acids Res. 2007 Jan; 35(Database issue):D527-32. PMID: 17098933; PMCID: PMC1669719.
    118. Grkovich A, Johnson CA, Buczynski MW, Dennis EA. Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent. J Biol Chem. 2006 Nov 03; 281(44):32978-87. PMID: 16950767.
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    119. Schaloske RH, Dennis EA. The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta. 2006 Nov; 1761(11):1246-59. PMID: 16973413.
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    120. Stephens D, Barbayianni E, Constantinou-Kokotou V, Peristeraki A, Six DA, Cooper J, Harkewicz R, Deems RA, Dennis EA, Kokotos G. Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides. J Med Chem. 2006 May 04; 49(9):2821-8. PMID: 16640343; PMCID: PMC2544624.
    121. Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, Bowers-Gentry RC, Buczynski MW, Cooper JA, Deems RA, Dennis EA. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res. 2006 May; 47(5):1097-111. PMID: 16479018.
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    122. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. PMID: 16203828.
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    123. Kessen UA, Schaloske RH, Stephens DL, Killermann Lucas K, Dennis EA. PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS. J Lipid Res. 2005 Nov; 46(11):2488-96. PMID: 16150819.
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    124. Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):223-34. PMID: 16099407.
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    125. Lucas KK, Dennis EA. Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):235-48. PMID: 16099408.
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    126. Shirai Y, Balsinde J, Dennis EA. Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs. Biochim Biophys Acta. 2005 Jul 15; 1735(2):119-29. PMID: 15967714.
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    127. Constantinou-Kokotou V, Peristeraki A, Kokotos CG, Six DA, Dennis EA. Synthesis and activity of 2-oxoamides containing long chain beta-amino acids. J Pept Sci. 2005 Jul; 11(7):431-5. PMID: 15635664.
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    128. Winstead MV, Lucas KK, Dennis EA. Group IV cytosolic phospholipase A2 mediates arachidonic acid release in H9c2 rat cardiomyocyte cells in response to hydrogen peroxide. Prostaglandins Other Lipid Mediat. 2005 Dec; 78(1-4):55-66. PMID: 16303605.
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    129. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. PMID: 15685208; PMCID: PMC1576074.
    130. Schaloske RH, Provins JW, Kessen UA, Dennis EA. Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. Biochim Biophys Acta. 2005 Feb 21; 1687(1-3):64-75. PMID: 15708354.
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    131. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. PMID: 15722563.
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    132. Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76. PMID: 15722561.
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    133. Kokotos G, Six DA, Loukas V, Smith T, Constantinou-Kokotou V, Hadjipavlou-Litina D, Kotsovolou S, Chiou A, Beltzner CC, Dennis EA. Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo. J Med Chem. 2004 Jul 01; 47(14):3615-28. PMID: 15214789.
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    134. Boegeman SC, Deems RA, Dennis EA. Phospholipid binding and the activation of group IA secreted phospholipase A2. Biochemistry. 2004 Apr 06; 43(13):3907-16. PMID: 15049698.
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    135. Lucas KK, Dennis EA. The ABC's of Group IV cytosolic phospholipase A2. Biochim Biophys Acta. 2004 Mar 22; 1636(2-3):213-8. PMID: 15164769.
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    136. Balboa MA, Shirai Y, Gaietta G, Ellisman MH, Balsinde J, Dennis EA. Localization of group V phospholipase A2 in caveolin-enriched granules in activated P388D1 macrophage-like cells. J Biol Chem. 2003 Nov 28; 278(48):48059-65. PMID: 12963740.
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    137. Phillips RM, Six DA, Dennis EA, Ghosh P. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem. 2003 Oct 17; 278(42):41326-32. PMID: 12915403.
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    138. Six DA, Dennis EA. Essential Ca(2+)-independent role of the group IVA cytosolic phospholipase A(2) C2 domain for interfacial activity. J Biol Chem. 2003 Jun 27; 278(26):23842-50. PMID: 12672805.
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    139. Whiles JA, Deems R, Vold RR, Dennis EA. Bicelles in structure-function studies of membrane-associated proteins. Bioorg Chem. 2002 Dec; 30(6):431-42. PMID: 12642127.
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    140. Balsinde J, Winstead MV, Dennis EA. Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett. 2002 Oct 30; 531(1):2-6. PMID: 12401193.
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    141. Balboa MA, Varela-Nieto I, Killermann Lucas K, Dennis EA. Expression and function of phospholipase A(2) in brain. FEBS Lett. 2002 Oct 30; 531(1):12-7. PMID: 12401195.
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    142. Kokotos G, Kotsovolou S, Six DA, Constantinou-Kokotou V, Beltzner CC, Dennis EA. Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2). J Med Chem. 2002 Jul 04; 45(14):2891-3. PMID: 12086476.
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    143. Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 01; 277(9):7010-20. PMID: 11744722.
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    144. Balboa MA, Balsinde J, Winstead MV, Tischfield JA, Dennis EA. Novel group V phospholipase A2 involved in arachidonic acid mobilization in murine P388D1 macrophages. J Biol Chem. 1996 Dec 13; 271(50):32381-4. PMID: 8943302.
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