Edward Dennis

Title(s)Recall Faculty, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Action of Lipolytic Enzymes
    NIH R35GM139641Jan 1, 2021 - Dec 31, 2025
    Role: Principal Investigator
    LIPIDOMICS BASED DIAGNOSTICS FOR NONALCOHOLIC STEATOHEPATITIS
    NIH R01DK105961Aug 26, 2015 - May 31, 2020
    Role: Principal Investigator
    Impact of Lipidomics Conference Series
    NIH R13GM106571Feb 15, 2014 - Jan 31, 2017
    Role: Principal Investigator
    LIPID MAPS
    NIH U54GM069338Aug 12, 2003 - Jul 31, 2014
    Role: Principal Investigator
    Lipid Maps
    NIH R24GM067877Sep 30, 2002 - Sep 30, 2003
    Role: Principal Investigator
    Regulation of Lipid Mediators in Spinal Microglia and Astrocytes
    NIH R01GM064611Sep 17, 2002 - Jan 31, 2013
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050May 15, 1997 - Mar 31, 2014
    Role: Co-Investigator
    LYSOPHOSPHOLIPASES
    NIH R01GM051606Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    FASEB SUMMER CONFERECE ON PHOSPHOLIPASES
    NIH R13GM047924Jun 1, 1992 - May 31, 1993
    Role: Principal Investigator
    REGULATION OF PROSTAGLANDIN BIOSYNTHESIS IN PARTURITION
    NIH R01HD026171Sep 1, 1989 - Dec 31, 2000
    Role: Principal Investigator
    1989 LIPID METABOLISM GORDON RESEARCH CONFERENCE
    NIH R13DK041231Jul 1, 1989 - May 31, 1990
    Role: Principal Investigator
    Action of Lipolytic Enzymes
    NIH R01GM020501Jun 1, 1977 - Dec 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Omega-3 Versus Omega-6 Fatty Acid Availability is Controlled by Hydrophobic Site Geometries of Phospholipase A2s. J Lipid Res. 2021 Aug 30; 100113. Hayashi D, Mouchlis VD, Dennis EA. PMID: 34474084.
      View in: PubMed   Mentions:    Fields:    
    2. Quality control requirements for the correct annotation of lipidomics data. Nat Commun. 2021 08 06; 12(1):4771. Köfeler HC, Eichmann TO, Ahrends R, Bowden JA, Danne-Rasche N, Dennis EA, Fedorova M, Griffiths WJ, Han X, Hartler J, Holcapek M, Jirásko R, Koelmel JP, Ejsing CS, Liebisch G, Ni Z, O'Donnell VB, Quehenberger O, Schwudke D, Shevchenko A, Wakelam MJO, Wenk MR, Wolrab D, Ekroos K. PMID: 34362906.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications. Circ Genom Precis Med. 2020 12; 13(6):e003019. O'Donnell VB, FitzGerald GA, Murphy RC, Liebisch G, Dennis EA, Quehenberger O, Subramaniam S, Wakelam MJO. PMID: 33196315.
      View in: PubMed   Mentions: 1     Fields:    
    4. Phosphatidylinositol metabolism, phospholipases, lipidomics, and cancer: In Memoriam: Michael J. O. Wakelam (1955-2020). J Lipid Res. 2020 06; 61(6):809-814. Dennis EA, O'Donnell VB. PMID: 33563398.
      View in: PubMed   Mentions:    Fields:    
    5. Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. J Lipid Res. 2020 12; 61(12):1539-1555. Liebisch G, Fahy E, Aoki J, Dennis EA, Durand T, Ejsing CS, Fedorova M, Feussner I, Griffiths WJ, Köfeler H, Merrill AH, Murphy RC, O'Donnell VB, Oskolkova O, Subramaniam S, Wakelam MJO, Spener F. PMID: 33037133.
      View in: PubMed   Mentions: 26     Fields:    
    6. Automated Annotation of Sphingolipids Including Accurate Identification of Hydroxylation Sites Using MSn Data. Anal Chem. 2020 10 20; 92(20):14054-14062. Hartler J, Armando AM, Trötzmüller M, Dennis EA, Köfeler HC, Quehenberger O. PMID: 33003696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. A global lipid map defines a network essential for Zika virus replication. Nat Commun. 2020 07 21; 11(1):3652. Leier HC, Weinstein JB, Kyle JE, Lee JY, Bramer LM, Stratton KG, Kempthorne D, Navratil AR, Tafesse EG, Hornemann T, Messer WB, Dennis EA, Metz TO, Barklis E, Tafesse FG. PMID: 32694525.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15789-15798. Tam VC, Suen R, Treuting PM, Armando A, Lucarelli R, Gorrochotegui-Escalante N, Diercks AH, Quehenberger O, Dennis EA, Aderem A, Gold ES. PMID: 32581129.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Plasma eicosanoids as noninvasive biomarkers of liver fibrosis in patients with nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2020; 13:1756284820923904. Caussy C, Chuang JC, Billin A, Hu T, Wang Y, Subramanian GM, Djedjos CS, Myers RP, Dennis EA, Loomba R. PMID: 32523627.
      View in: PubMed   Mentions:
    10. Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential? Sci Rep. 2020 05 18; 10(1):8161. Venn-Watson S, Lumpkin R, Dennis EA. PMID: 32424181.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. 2-Oxoester Phospholipase A2 Inhibitors with Enhanced Metabolic Stability. Biomolecules. 2020 03 24; 10(3). Koutoulogenis GS, Kokotou MG, Hayashi D, Mouchlis VD, Dennis EA, Kokotos G. PMID: 32213911.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A2 inhibitors. Adv Biol Regul. 2020 05; 76:100719. Mouchlis VD, Mu C, Hammons R, Dennis EA. PMID: 32199750.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    14. Correction to "Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)". ACS Omega. 2019 Jun 30; 4(6):10714. Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. PMID: 31460169.
      View in: PubMed   Mentions:
    15. AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. J Lipid Res. 2019 05; 60(5):937-952. Declèves AE, Mathew AV, Armando AM, Han X, Dennis EA, Quehenberger O, Sharma K. PMID: 30862696.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019 03 28; 62(6):2916-2927. Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G. PMID: 30798607.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. J Med Chem. 2019 02 28; 62(4):1999-2007. Mouchlis VD, Armando A, Dennis EA. PMID: 30615445.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 03 21; 26(3):433-442.e4. Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. PMID: 30661990.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training. Sci Signal. 2019 01 08; 12(563). O'Donnell VB, Dennis EA, Wakelam MJO, Subramaniam S. PMID: 30622195.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    20. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. PMID: 30130298.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Quantitative determination of esterified eicosanoids and related oxygenated metabolites after base hydrolysis. J Lipid Res. 2018 12; 59(12):2436-2445. Quehenberger O, Dahlberg-Wright S, Jiang J, Armando AM, Dennis EA. PMID: 30323111.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Phospholipase A2 catalysis and lipid mediator lipidomics. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 06; 1864(6):766-771. Mouchlis VD, Dennis EA. PMID: 30905345.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. J Lipid Res. 2018 10; 59(10):2001-2017. Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešic M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR. PMID: 30115755.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    24. Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2). ACS Omega. 2018 Aug 31; 3(8):8843-8853. Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. PMID: 30197994.
      View in: PubMed   Mentions:
    25. Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity. J Am Chem Soc. 2018 03 07; 140(9):3285-3291. Mouchlis VD, Chen Y, McCammon JA, Dennis EA. PMID: 29342349.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo. J Am Chem Soc. 2018 01 10; 140(1):235-243. Navratil AR, Shchepinov MS, Dennis EA. PMID: 29206462.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. PMID: 29404441.
      View in: PubMed   Mentions:
    28. Review of four major distinct types of human phospholipase A2. Adv Biol Regul. 2018 01; 67:212-218. Vasquez AM, Mouchlis VD, Dennis EA. PMID: 29248300.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    29. Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res. 2017 12; 58(12):2275-2288. Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S. PMID: 28986437.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    30. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Sci Rep. 2017 08 01; 7(1):7025. Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, Kokotos G. PMID: 28765606.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis. Biochimie. 2017 Oct; 141:86-90. Brown CR, Dennis EA. PMID: 28630010.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. 2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors. Bioorg Med Chem. 2017 02 01; 25(3):926-940. Smyrniotou A, Kokotou MG, Mouchlis VD, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V. PMID: 28034646.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    33. Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma. J Allergy Clin Immunol. 2017 04; 139(4):1379-1383. Sokolowska M, Chen LY, Liu Y, Martinez-Anton A, Logun C, Alsaaty S, Cuento RA, Cai R, Sun J, Quehenberger O, Armando AM, Dennis EA, Levine SJ, Shelhamer JH. PMID: 27826094.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease. J Biol Chem. 2016 Nov 18; 291(47):24431-24448. Dennis EA. PMID: 27555328.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorg Med Chem. 2016 10 01; 24(19):4544-4554. Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. PMID: 27522578.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 10 15; 24(20):4801-4811. Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. PMID: 27320659.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    37. Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships. J Med Chem. 2016 05 12; 59(9):4403-14. Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. PMID: 27087127.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    38. Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages. J Phys Chem B. 2016 08 25; 120(33):8346-53. Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S. PMID: 27063350.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. Membrane and inhibitor interactions of intracellular phospholipases A2. Adv Biol Regul. 2016 05; 61:17-24. Mouchlis VD, Dennis EA. PMID: 26774606.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    40. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug; 15(8):511-23. Dennis EA, Norris PC. PMID: 26139350.
      View in: PubMed   Mentions: 330     Fields:    Translation:HumansAnimalsCells
    41. Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease. J Lipid Res. 2015 Jul; 56(7):1245-7. Dennis EA. PMID: 26031662.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E516-25. Mouchlis VD, Bucher D, McCammon JA, Dennis EA. PMID: 25624474.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    43. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-736. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. PMID: 25598080.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCTClinical Trials
    44. Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids. Biochim Biophys Acta. 2015 Apr; 1851(4):456-68. Astarita G, Kendall AC, Dennis EA, Nicolaou A. PMID: 25486530.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    45. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res. 2015 Jan; 56(1):185-92. Loomba R, Quehenberger O, Armando A, Dennis EA. PMID: 25404585.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    46. Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies. J Lipid Res. 2014 Nov; 55(11):2432-42. Baker PR, Armando AM, Campbell JL, Quehenberger O, Dennis EA. PMID: 25225680.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    47. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25; 57(18):7523-35. Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. PMID: 25152071.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    48. Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12746-51. Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA. PMID: 25139986.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    49. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res. 2014 Nov; 12(11):1677-88. Jiao J, Ishikawa TO, Dumlao DS, Norris PC, Magyar CE, Mikulec C, Catapang A, Dennis EA, Fischer SM, Herschman HR. PMID: 25063587.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    50. Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples. J Chromatogr A. 2014 Sep 12; 1359:60-9. Wang Y, Armando AM, Quehenberger O, Yan C, Dennis EA. PMID: 25074422.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    51. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. PMID: 24613321.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    52. Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophys J. 2014 Feb 18; 106(4):966-75. Kihara Y, Gupta S, Maurya MR, Armando A, Shah I, Quehenberger O, Glass CK, Dennis EA, Subramaniam S. PMID: 24559999.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    53. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. 2014 Jun; 35(6):1310-9. Jiao J, Mikulec C, Ishikawa TO, Magyar C, Dumlao DS, Dennis EA, Fischer SM, Herschman H. PMID: 24469308.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    54. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. PMID: 24376657.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    55. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13; 288(50):35812-23. Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. PMID: 24189069.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    56. Desperately seeking Flexner: time to reemphasize basic science in medical education. Acad Med. 2013 Oct; 88(10):1405-6. Kennelly PJ, Bond JS, Masters BS, Dennis EA, Brenner C, Raben DM. PMID: 24064614.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-214. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. PMID: 24074869.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    58. A lipidomic perspective on inflammatory macrophage eicosanoid signaling. Adv Biol Regul. 2014 Jan; 54:99-110. Norris PC, Dennis EA. PMID: 24113376.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    59. Lipidomics technologies at the end of the first decade and the beginning of the next. Adv Nutr. 2013 Sep 01; 4(5):565-7. Merrill AH, Dennis EA, McDonald JG, Fahy E. PMID: 24038259.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    60. Insertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations. PLoS Comput Biol. 2013; 9(7):e1003156. Bucher D, Hsu YH, Mouchlis VD, Dennis EA, McCammon JA. PMID: 23935474.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    61. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15; 21(18):5823-9. Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. PMID: 23916152.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    62. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res. 2013 Oct; 54(10):2815-30. Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum JL, Koschinsky ML, Tsimikas S. PMID: 23828779.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    63. Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell. 2013 Jul 03; 154(1):213-27. Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A. PMID: 23827684.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    64. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res. 2013 Sep; 54(9):2525-42. Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. PMID: 23776196.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    65. Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. PLoS One. 2013; 8(3):e59267. Hsu YH, Dumlao DS, Cao J, Dennis EA. PMID: 23533611.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    66. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May; 27(5):1939-49. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. PMID: 23382512.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    67. Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics. J Am Chem Soc. 2013 Jan 30; 135(4):1330-7. Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL, McCammon JA, Dennis EA. PMID: 23256506.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    68. Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem. 2013 Jan 18; 288(3):1806-13. Cao J, Burke JE, Dennis EA. PMID: 23209293.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    69. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. J Lipid Res. 2013 Jan; 54(1):127-33. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. PMID: 23089916.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    70. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28; 151(1):138-52. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. PMID: 23021221.
      View in: PubMed   Mentions: 197     Fields:    Translation:AnimalsCells
    71. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. J Lipid Res. 2012 Dec; 53(12):2773-90. van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. PMID: 22969153.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    72. Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. J Biol Chem. 2012 Oct 12; 287(42):35260-35274. Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao JLUM, Dennis EA, Moise AR. PMID: 22923616.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    73. Dietary fish oil substitution alters the eicosanoid profile in ankle joints of mice during Lyme infection. J Nutr. 2012 Aug; 142(8):1582-9. Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hanks JH, Halpin R, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR. PMID: 22695969.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    74. Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8517-22. Norris PC, Dennis EA. PMID: 22586114.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    75. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6721-6. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. PMID: 22493235.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    76. The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6036-41. Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA. PMID: 22492977.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    77. Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism. Mol Cell Proteomics. 2012 Jul; 11(7):M111.014746. Sabidó E, Quehenberger O, Shen Q, Chang CY, Shah I, Armando AM, Andreyev A, Vitek O, Dennis EA, Aebersold R. PMID: 22361236.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    78. Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics. J Chem Inf Model. 2012 Jan 23; 52(1):243-54. Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. PMID: 22196172.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    79. LIPID MAPS-Nature Lipidomics Gateway: An Online Resource for Students and Educators Interested in Lipids. J Chem Educ. 2012 Jan 10; 89(2):291-292. Sud M, Fahy E, Cotter D, Dennis EA, Subramaniam S. PMID: 24764601.
      View in: PubMed   Mentions: 15     Fields:    
    80. Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. J Biol Chem. 2012 Mar 30; 287(14):11469-80. Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K. PMID: 22199362.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    81. The human plasma lipidome. N Engl J Med. 2011 Nov 10; 365(19):1812-23. Quehenberger O, Dennis EA. PMID: 22070478.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    82. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011 Dec; 152(12):2881-2891. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. PMID: 22019135.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    83. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev. 2011 Oct 12; 111(10):6130-85. Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. PMID: 21910409.
      View in: PubMed   Mentions: 272     Fields:    Translation:Humans
    84. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. FASEB J. 2011 Dec; 25(12):4240-52. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S. PMID: 21868473.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    85. High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry. Biochim Biophys Acta. 2011 Nov; 1811(11):648-56. Quehenberger O, Armando AM, Dennis EA. PMID: 21787881.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    86. High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines. Biochim Biophys Acta. 2011 Nov; 1811(11):724-36. Dumlao DS, Buczynski MW, Norris PC, Harkewicz R, Dennis EA. PMID: 21689782.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    87. Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. J Leukoc Biol. 2011 Sep; 90(3):563-74. Norris PC, Reichart D, Dumlao DS, Glass CK, Dennis EA. PMID: 21653236.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    88. Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic α-helix. Biochemistry. 2011 Jun 14; 50(23):5314-21. Cao J, Hsu YH, Li S, Woods VL, Dennis EA. PMID: 21553808.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    89. Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol. 2011 Aug; 205(2):156.e15-25. Quehenberger O, Yamashita T, Armando AM, Dennis EA, Palinski W. PMID: 21621186.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsPHPublic Health
    90. Applications of mass spectrometry to lipids and membranes. Annu Rev Biochem. 2011; 80:301-25. Harkewicz R, Dennis EA. PMID: 21469951.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    91. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17; 285(51):39976-85. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. PMID: 20923771.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    92. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. PMID: 20710028.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    93. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res. 2010 Nov; 51(11):3299-305. Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA. PMID: 20671299.
      View in: PubMed   Mentions: 367     Fields:    Translation:Humans
    94. Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res. 2010 Sep; 51(9):2785-97. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA. PMID: 20574076.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    95. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem. 2010 Aug; 114(4):981-93. Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. PMID: 20492349.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    96. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13; 53(9):3602-10. Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA. PMID: 20369880.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    97. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med. 2010 Mar; 16(3):313-8. Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK. PMID: 20154695.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    98. Application of proteomic marker ensembles to subcellular organelle identification. Mol Cell Proteomics. 2010 Feb; 9(2):388-402. Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. PMID: 19884172.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    99. Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. J Immunol. 2009 Nov 01; 183(9):5644-53. Blaho VA, Buczynski MW, Dennis EA, Brown CR. PMID: 19843949.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    100. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009 Aug 28; 284(35):23652-61. Hsu YH, Burke JE, Li S, Woods VL, Dennis EA. PMID: 19556238.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    101. Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. J Am Chem Soc. 2009 Jun 17; 131(23):8083-91. Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL, McCammon JA, Dennis EA. PMID: 19459633.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    102. An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis. Biophys J. 2009 Jun 03; 96(11):4542-51. Gupta S, Maurya MR, Stephens DL, Dennis EA, Subramaniam S. PMID: 19486676.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    103. Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. J Biol Chem. 2009 Aug 07; 284(32):21599-612. Blaho VA, Buczynski MW, Brown CR, Dennis EA. PMID: 19487688.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    104. 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 01; 17(13):4833-43. Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA, Kokotos G. PMID: 19443224.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    105. Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1. Dennis EA, Witztum JL. PMID: 19346336.
      View in: PubMed   Mentions: 1     Fields:    
    106. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res. 2009 Jun; 50(6):1015-38. Buczynski MW, Dumlao DS, Dennis EA. PMID: 19244215.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    107. TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent. Biochim Biophys Acta. 2009 Oct; 1791(10):975-82. Grkovich A, Armando A, Quehenberger O, Dennis EA. PMID: 19230851.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    108. Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain. 2009 May; 132(Pt 5):1221-35. Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G, David S. PMID: 19218359.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    109. Lipidomics joins the omics evolution. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2089-90. Dennis EA. PMID: 19211786.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    110. Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling. Adv Enzyme Regul. 2009; 49(1):114-20. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Grkovich A, Dennis EA. PMID: 19534028.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    111. Founding, early history, and transformation of the Journal for Lipid Research to an American Society of Biochemistry and Molecular Biology journal. J Lipid Res. 2009 Apr; 50 Suppl:S3-8. Dennis EA. PMID: 19116414.
      View in: PubMed   Mentions: 1     Fields:    
    112. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25; 51(24):8027-37. Baskakis C, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. PMID: 19053783.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    113. Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res. 2009 Apr; 50 Suppl:S9-14. Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. PMID: 19098281.
      View in: PubMed   Mentions: 359     Fields:    
    114. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res. 2009 Apr; 50 Suppl:S237-42. Burke JE, Dennis EA. PMID: 19011112.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    115. Lipidomics analysis of essential fatty acids in macrophages. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov; 79(3-5):123-9. Quehenberger O, Armando A, Dumlao D, Stephens DL, Dennis EA. PMID: 18996688.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    116. Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15; 16(24):10257-69. Antonopoulou G, Barbayianni E, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. PMID: 18993078.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    117. Phospholipase A2 biochemistry. Cardiovasc Drugs Ther. 2009 Feb; 23(1):49-59. Burke JE, Dennis EA. PMID: 18931897.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimals
    118. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 2009 Jan 08; 113(2):447-57. Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. PMID: 18840708.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    119. Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2. J Pept Sci. 2008 Oct; 14(10):1111-20. Antonopoulou G, Magrioti V, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. PMID: 18618424.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    120. A macrophage cell model for selective metalloproteinase inhibitor design. Chembiochem. 2008 Sep 01; 9(13):2087-95. Jacobsen FE, Buczynski MW, Dennis EA, Cohen SM. PMID: 18666306.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    121. A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem. 2008 Nov 07; 283(45):31227-36. Burke JE, Hsu YH, Deems RA, Li S, Woods VL, Dennis EA. PMID: 18753135.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    122. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct; 131(Pt 10):2620-31. López-Vales R, Navarro X, Shimizu T, Baskakis C, Kokotos G, Constantinou-Kokotou V, Stephens D, Dennis EA, David S. PMID: 18718965.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    123. Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry. 2008 Jun 17; 47(24):6451-9. Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. PMID: 18500818.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    124. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. PMID: 18263582.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    125. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2008 Apr 11; 283(15):9820-7. Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL, Dennis EA. PMID: 18211893.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    126. Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2. J Pept Sci. 2007 Oct; 13(10):634-41. Moutevelis-Minakakis P, Neokosmidi A, Filippakou M, Stephens D, Dennis EA, Kokotos G. PMID: 17631670.
      View in: PubMed   Mentions: 6     Fields:    
    127. Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2. J Med Chem. 2007 Aug 23; 50(17):4222-35. Six DA, Barbayianni E, Loukas V, Constantinou-Kokotou V, Hadjipavlou-Litina D, Stephens D, Wong AC, Magrioti V, Moutevelis-Minakakis P, Baker SF, Dennis EA, Kokotos G. PMID: 17672443.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    128. TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells. J Biol Chem. 2007 Aug 03; 282(31):22834-47. Buczynski MW, Stephens DL, Bowers-Gentry RC, Grkovich A, Deems RA, Dennis EA. PMID: 17535806.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    129. Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry. Methods Enzymol. 2007; 432:59-82. Deems R, Buczynski MW, Bowers-Gentry R, Harkewicz R, Dennis EA. PMID: 17954213.
      View in: PubMed   Mentions: 60     Fields:    
    130. The lipid maps initiative in lipidomics. Methods Enzymol. 2007; 432:171-83. Schmelzer K, Fahy E, Subramaniam S, Dennis EA. PMID: 17954217.
      View in: PubMed   Mentions: 49     Fields:    
    131. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. J Biol Chem. 2007 Feb 02; 282(5):2899-910. Harkewicz R, Fahy E, Andreyev A, Dennis EA. PMID: 17135246.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    132. LMSD: LIPID MAPS structure database. Nucleic Acids Res. 2007 Jan; 35(Database issue):D527-32. Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. PMID: 17098933.
      View in: PubMed   Mentions: 296     Fields:    Translation:HumansCells
    133. Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent. J Biol Chem. 2006 Nov 03; 281(44):32978-87. Grkovich A, Johnson CA, Buczynski MW, Dennis EA. PMID: 16950767.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    134. The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta. 2006 Nov; 1761(11):1246-59. Schaloske RH, Dennis EA. PMID: 16973413.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimals
    135. Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides. J Med Chem. 2006 May 04; 49(9):2821-8. Stephens D, Barbayianni E, Constantinou-Kokotou V, Peristeraki A, Six DA, Cooper J, Harkewicz R, Deems RA, Dennis EA, Kokotos G. PMID: 16640343.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    136. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res. 2006 May; 47(5):1097-111. Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, Bowers-Gentry RC, Buczynski MW, Cooper JA, Deems RA, Dennis EA. PMID: 16479018.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    137. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. PMID: 16203828.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    138. PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS. J Lipid Res. 2005 Nov; 46(11):2488-96. Kessen UA, Schaloske RH, Stephens DL, Killermann Lucas K, Dennis EA. PMID: 16150819.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    139. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):223-34. Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. PMID: 16099407.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    140. Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):235-48. Lucas KK, Dennis EA. PMID: 16099408.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    141. Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs. Biochim Biophys Acta. 2005 Jul 15; 1735(2):119-29. Shirai Y, Balsinde J, Dennis EA. PMID: 15967714.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    142. Synthesis and activity of 2-oxoamides containing long chain beta-amino acids. J Pept Sci. 2005 Jul; 11(7):431-5. Constantinou-Kokotou V, Peristeraki A, Kokotos CG, Six DA, Dennis EA. PMID: 15635664.
      View in: PubMed   Mentions: 8     Fields:    
    143. Group IV cytosolic phospholipase A2 mediates arachidonic acid release in H9c2 rat cardiomyocyte cells in response to hydrogen peroxide. Prostaglandins Other Lipid Mediat. 2005 Dec; 78(1-4):55-66. Winstead MV, Lucas KK, Dennis EA. PMID: 16303605.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    144. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. PMID: 15685208.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    145. Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. Biochim Biophys Acta. 2005 Feb 21; 1687(1-3):64-75. Schaloske RH, Provins JW, Kessen UA, Dennis EA. PMID: 15708354.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    146. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. PMID: 15722563.
      View in: PubMed   Mentions: 330     Fields:    Translation:Cells
    147. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76. Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. PMID: 15722561.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    148. Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo. J Med Chem. 2004 Jul 01; 47(14):3615-28. Kokotos G, Six DA, Loukas V, Smith T, Constantinou-Kokotou V, Hadjipavlou-Litina D, Kotsovolou S, Chiou A, Beltzner CC, Dennis EA. PMID: 15214789.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    149. Phospholipid binding and the activation of group IA secreted phospholipase A2. Biochemistry. 2004 Apr 06; 43(13):3907-16. Boegeman SC, Deems RA, Dennis EA. PMID: 15049698.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    150. The ABC's of Group IV cytosolic phospholipase A2. Biochim Biophys Acta. 2004 Mar 22; 1636(2-3):213-8. Lucas KK, Dennis EA. PMID: 15164769.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    151. Localization of group V phospholipase A2 in caveolin-enriched granules in activated P388D1 macrophage-like cells. J Biol Chem. 2003 Nov 28; 278(48):48059-65. Balboa MA, Shirai Y, Gaietta G, Ellisman MH, Balsinde J, Dennis EA. PMID: 12963740.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    152. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem. 2003 Oct 17; 278(42):41326-32. Phillips RM, Six DA, Dennis EA, Ghosh P. PMID: 12915403.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    153. Essential Ca(2+)-independent role of the group IVA cytosolic phospholipase A(2) C2 domain for interfacial activity. J Biol Chem. 2003 Jun 27; 278(26):23842-50. Six DA, Dennis EA. PMID: 12672805.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    154. Bicelles in structure-function studies of membrane-associated proteins. Bioorg Chem. 2002 Dec; 30(6):431-42. Whiles JA, Deems R, Vold RR, Dennis EA. PMID: 12642127.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    155. Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett. 2002 Oct 30; 531(1):2-6. Balsinde J, Winstead MV, Dennis EA. PMID: 12401193.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    156. Expression and function of phospholipase A(2) in brain. FEBS Lett. 2002 Oct 30; 531(1):12-7. Balboa MA, Varela-Nieto I, Killermann Lucas K, Dennis EA. PMID: 12401195.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    157. Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2). J Med Chem. 2002 Jul 04; 45(14):2891-3. Kokotos G, Kotsovolou S, Six DA, Constantinou-Kokotou V, Beltzner CC, Dennis EA. PMID: 12086476.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    158. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 01; 277(9):7010-20. Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. PMID: 11744722.
      View in: PubMed   Mentions: 80     Fields:    Translation:Cells
    159. Novel group V phospholipase A2 involved in arachidonic acid mobilization in murine P388D1 macrophages. J Biol Chem. 1996 Dec 13; 271(50):32381-4. Balboa MA, Balsinde J, Winstead MV, Tischfield JA, Dennis EA. PMID: 8943302.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    Edward's Networks
    Concepts (613)
    Derived automatically from this person's publications.
    _
    Co-Authors (44)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _