Phillipp Hartmann

Title(s)Assistant Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Regensburg, Regensburg, GermanyMD11/2013Medicine
    University of California San Diego, La Jolla, CAPostdoctoral06/2016Gastroenterology
    University of California San Diego, La Jolla, CAResident06/2019Pediatrics
    University of California San Diego, La Jolla, CAFellow07/2022Pediatric Gastroenterology
    University of California San Diego, La Jolla, CAMAS06/2023Clinical Research

    Collapse Overview 
    Collapse Overview
    Dr. Hartmann is an Assistant Professor in Pediatrics at the University of California San Diego and is interested in the role of the intestinal microbiome in various liver diseases, including pediatric metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), as well as obesity. He aims to develop novel diagnostic and therapeutic strategies that will help to design more personalized treatment approaches.

    Collapse Research 
    Collapse Research Activities and Funding
    NIH/UCSD Altman Clinical and Translational Research Institute (ACTRI) KL2TR001444May 1, 2023 - Apr 30, 2026
    Role: Principal Investigator
    Role of Candida albicans for the development of non-alcoholic steatohepatitis
    American Association for the Study of Liver Diseases (AASLD), Pinnacle Award PNC22-159963Jul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator
    Intestinal Mycobiome in Pediatric Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
    NIH/NICHD K12HD000850-36Jul 1, 2020 - Jun 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fecal gelatinase does not predict mortality in patients with alcohol-associated hepatitis. Microb Cell. 2024; 11:328-338. Yang Y, Hartmann P, Schnabl B. PMID: 39206205; PMCID: PMC11350238.
      View in: PubMed   Mentions:
    2. Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. Gut. 2024 Jul 20. Kreimeyer H, Gonzalez CG, Fondevila MF, Hsu CL, Hartmann P, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Gonzalez DJ, Schnabl B. PMID: 39033024.
      View in: PubMed   Mentions:    Fields:    
    3. Do Glucagon-like Peptide Receptor Agonists Cause Postendoscopic Aspiration Pneumonia? Gastroenterology. 2024 Apr 04. Hartmann P. PMID: 38580130.
      View in: PubMed   Mentions:    Fields:    
    4. Collagenous gastritis with elevated fecal calprotectin in a pediatric patient. JPGN Rep. 2024 May; 5(2):152-157. Rodriguez N, Kumar S, Mo J, Hartmann P. PMID: 38756119; PMCID: PMC11093908.
      View in: PubMed   Mentions:
    5. Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Hepatology. 2024 08 01; 80(2):403-417. Yamazaki T, Kouno T, Hsu CL, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Schnabl B, AlcHepNet Investigators. PMID: 38377466; PMCID: PMC11268475.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease. Gut Microbes. 2024 Jan-Dec; 16(1):2307586. Viebahn G, Hartmann P, Lang S, Demir M, Zhang X, Fouts DE, Stärkel P, Schnabl B. PMID: 38298161; PMCID: PMC10841010.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. How to calculate sample size in animal and human studies. Front Med (Lausanne). 2023; 10:1215927. Zhang X, Hartmann P. PMID: 37663663; PMCID: PMC10469945.
      View in: PubMed   Mentions: 8  
    8. Noninvasive biomarkers in pediatric nonalcoholic fatty liver disease. World J Hepatol. 2023 May 27; 15(5):609-640. Jayasekera D, Hartmann P. PMID: 37305367; PMCID: PMC10251277.
      View in: PubMed   Mentions: 4  
    9. Fecal cytolysin does not predict disease severity in acutely decompensated cirrhosis and acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int. 2023 Oct; 22(5):474-481. Hartmann P, Lang S, Schierwagen R, Klein S, Praktiknjo M, Trebicka J, Schnabl B. PMID: 37198098; PMCID: PMC10797562.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. Probiotics, prebiotics, and synbiotics in nonalcoholic fatty liver disease and alcohol-associated liver disease. Am J Physiol Gastrointest Liver Physiol. 2023 07 01; 325(1):G42-G61. Kaufmann B, Seyfried N, Hartmann D, Hartmann P. PMID: 37129252; PMCID: PMC10312326.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Global and national prevalence of nonalcoholic fatty liver disease in adolescents: An analysis of the global burden of disease study 2019. Hepatology. 2023 10 01; 78(4):1168-1181. Hartmann P, Zhang X, Loomba R, Schnabl B. PMID: 37021791; PMCID: PMC10521800.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    12. Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice. Alcohol Clin Exp Res (Hoboken). 2023 May; 47(5):856-867. Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, Hartmann P, Cabré N, Llorente C, Galbert C, Emond P, Sokol H, James M, Chao CC, Gao JR, Perreault M, Hava DL, Schnabl B. PMID: 36871955; PMCID: PMC10795770.
      View in: PubMed   Mentions: 8     Fields:    
    13. Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. Cell Host Microbe. 2023 03 08; 31(3):389-404.e7. Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, Huang WJM, Lee J, Lee SM, Carvalho-Gontijo R, Zhang V, Hoffmann JP, Kolls JK, Raz E, Brenner DA, Kisseleva T, LeibundGut-Landmann S, Bacher P, Stärkel P, Schnabl B. PMID: 36893735; PMCID: PMC10039706.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. IgY antibodies against cytolysin reduce ethanol-induced liver disease in mice. Hepatology. 2023 07 01; 78(1):295-306. Cabré N, Hartmann P, Llorente C, Kouno T, Wang Y, Zeng S, Kim HY, Zhang X, Kisseleva T, Iyer S, Kudumala S, Schnabl B. PMID: 36811393; PMCID: PMC10293100.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    15. Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease. Dig Dis Sci. 2023 07; 68(7):3059-3069. Hsu CL, Wang Y, Duan Y, Chu H, Hartmann P, Llorente C, Zhou R, Schnabl B. PMID: 36807831; PMCID: PMC10313731.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Malassezia restricta promotes alcohol-induced liver injury. Hepatol Commun. 2023 02 01; 7(2):e0029. Zeng S, Hartmann P, Park M, Duan Y, Lang S, Llorente C, Wang Y, Cabré N, Fouts DE, Bacher P, Jung WH, Stärkel P, Schnabl B. PMID: 36706195; PMCID: PMC9988279.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    17. Can a mucosal microbiota signature predict disease severity, survival, and disease recurrence in PSC? Hepatology. 2023 03 01; 77(3):709-711. Hartmann P, Schnabl B. PMID: 36626635.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Fungal infections and the fungal microbiome in hepatobiliary disorders. J Hepatol. 2023 04; 78(4):836-851. Hartmann P, Schnabl B. PMID: 36565724; PMCID: PMC10033447.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    19. A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues. Alcohol Clin Exp Res (Hoboken). 2023 01; 47(1):36-44. Crotty K, Anton P, Coleman LG, Morris NL, Lewis SA, Samuelson DR, McMahan RH, Hartmann P, Kim A, Ratna A, Mandrekar P, Wyatt TA, Choudhry MA, Kovacs EJ, McCullough R, Yeligar SM. PMID: 36446606; PMCID: PMC9974783.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Inexpensive, Accurate, and Stable Method to Quantitate Blood Alanine Aminotransferase (ALT) Levels. Methods Protoc. 2022 Oct 14; 5(5). Hartmann P, Schnabl B. PMID: 36287053; PMCID: PMC9610295.
      View in: PubMed   Mentions: 2  
    21. Liver cirrhosis and immune dysfunction. Int Immunol. 2022 09 06; 34(9):455-466. Hasa E, Hartmann P, Schnabl B. PMID: 35792761; PMCID: PMC9447994.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    22. Editorial: The Microbiome in Hepatobiliary and Intestinal Disease. Front Physiol. 2022; 13:893074. Hartmann P. PMID: 35492588; PMCID: PMC9044070.
      View in: PubMed   Mentions: 4  
    23. Intestinal virome in patients with alcohol use disorder and after abstinence. Hepatol Commun. 2022 08; 6(8):2058-2069. Hsu CL, Zhang X, Jiang L, Lang S, Hartmann P, Pride D, Fouts DE, Stärkel P, Schnabl B. PMID: 35368152; PMCID: PMC9315129.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    24. Colesevelam ameliorates non-alcoholic steatohepatitis and obesity in mice. Hepatol Int. 2022 Apr; 16(2):359-370. Hartmann P, Duan Y, Miyamoto Y, Demir M, Lang S, Hasa E, Stern P, Yamashita D, Conrad M, Eckmann L, Schnabl B. PMID: 35075592; PMCID: PMC9013343.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    25. The fecal mycobiome in non-alcoholic fatty liver disease. J Hepatol. 2022 04; 76(4):788-799. Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Stärkel P, Fouts DE, Schnabl B. PMID: 34896404; PMCID: PMC8981795.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    26. Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases. Hepatology. 2022 01; 75(1):219-228. Ginès P, Castera L, Lammert F, Graupera I, Serra-Burriel M, Allen AM, Wong VW, Hartmann P, Thiele M, Caballeria L, de Knegt RJ, Grgurevic I, Augustin S, Tsochatzis EA, Schattenberg JM, Guha IN, Martini A, Morillas RM, Garcia-Retortillo M, de Koning HJ, Fabrellas N, Pich J, Ma AT, Diaz MA, Roulot D, Newsome PN, Manns M, Kamath PS, Krag A, LiverScreen Consortium Investigators. PMID: 34537988.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansPHPublic Health
    27. Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder. Front Physiol. 2021; 12:699253. Hartmann P, Lang S, Zeng S, Duan Y, Zhang X, Wang Y, Bondareva M, Kruglov A, Fouts DE, Stärkel P, Schnabl B. PMID: 34349667; PMCID: PMC8327211.
      View in: PubMed   Mentions: 35  
    28. Complete Absence of the Extrahepatic Biliary Tree in a Newborn With Pigmented Stools. Pediatrics. 2021 07; 148(1). Hartmann P, Carter R, Keller B, Saenz NC, Schwarz KB. PMID: 34398808.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. New Developments in Microbiome in Alcohol-Associated and Nonalcoholic Fatty Liver Disease. Semin Liver Dis. 2021 01; 41(1):87-102. Hartmann P, Schnabl B. PMID: 33957682; PMCID: PMC8163568.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either. Am J Physiol Gastrointest Liver Physiol. 2019 05 01; 316(5):G563-G573. Hartmann P, Chu H, Duan Y, Schnabl B. PMID: 30767680; PMCID: PMC6580239.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    31. Reply to: "Finding fibroblast growth factor 19 during cholestasis: Does x mark the spot? J Hepatol. 2018 12; 69(6):1400-1401. Brandl K, Hartmann P, Jih LJ, Pizzo DP, Schnabl B. PMID: 30301625.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2018 06; 67(6):2150-2166. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 29159825; PMCID: PMC5962369.
      View in: PubMed   Mentions: 125     Fields:    Translation:Animals
    33. Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis. J Hepatol. 2018 08; 69(2):396-405. Brandl K, Hartmann P, Jih LJ, Pizzo DP, Argemi J, Ventura-Cots M, Coulter S, Liddle C, Ling L, Rossi SJ, DePaoli AM, Loomba R, Mehal WZ, Fouts DE, Lucey MR, Bosques-Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross D, Stärkel P, Ho SB, Bataller R, Schnabl B. PMID: 29654817; PMCID: PMC6054564.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    34. Risk factors for progression of and treatment options for NAFLD in children. Clin Liver Dis (Hoboken). 2018 Jan; 11(1):11-15. Hartmann P, Schnabl B. PMID: 29629177; PMCID: PMC5881937.
      View in: PubMed   Mentions: 17  
    35. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30; 127(7):2829-2841. Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. PMID: 28530644; PMCID: PMC5490775.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    36. Tiny RNA with great effects: miR-155 in alcoholic liver disease. J Hepatol. 2016 06; 64(6):1214-6. Hartmann P, Tacke F. PMID: 26948494.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    37. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10; 19(2):227-39. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B. PMID: 26867181; PMCID: PMC4786170.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    38. Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 01; 310(5):G310-22. Hartmann P, Seebauer CT, Mazagova M, Horvath A, Wang L, Llorente C, Varki NM, Brandl K, Ho SB, Schnabl B. PMID: 26702135; PMCID: PMC4773827.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    39. Alcoholic liver disease: the gut microbiome and liver cross talk. Alcohol Clin Exp Res. 2015 May; 39(5):763-75. Hartmann P, Seebauer CT, Schnabl B. PMID: 25872593; PMCID: PMC4402724.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimals
    40. Methods to determine intestinal permeability and bacterial translocation during liver disease. J Immunol Methods. 2015 Jun; 421:44-53. Wang L, Llorente C, Hartmann P, Yang AM, Chen P, Schnabl B. PMID: 25595554; PMCID: PMC4451427.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    41. Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids. J Hepatol. 2014 Jun; 60(6):1259-67. Wang L, Hartmann P, Haimerl M, Bathena SP, Sjöwall C, Almer S, Alnouti Y, Hofmann AF, Schnabl B. PMID: 24560660; PMCID: PMC4028388.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    42. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013 Jul; 58(1):108-19. Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, Ho SB, Schnabl B. PMID: 23408358; PMCID: PMC3695050.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimals
    43. The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease. Front Physiol. 2012; 3:402. Hartmann P, Chen WC, Schnabl B. PMID: 23087650; PMCID: PMC3468817.
      View in: PubMed   Mentions: 60  
    44. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology. 2012 Nov; 143(5):1330-1340.e1. Hartmann P, Haimerl M, Mazagova M, Brenner DA, Schnabl B. PMID: 22841787; PMCID: PMC3482543.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
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