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Young Chul Kim

Title(s)ASSOC PROJ SCIENTIST (WOS), Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailyck007@ucsd.edu
ORCID ORCID Icon0000-0002-6782-2186 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice. Physiol Rep. 2025 Apr; 13(7):e70217. Goodluck H, Zemljic-Harpf A, Galdino OA, Kanoo S, Lopez N, Kim YC, Vallon V. PMID: 40151088; PMCID: PMC11950634.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. ASK1 limits kidney glucose reabsorption, growth, and mid-late proximal tubule KIM-1 induction when diabetes and Western diet are combined with SGLT2 inhibition. Am J Physiol Renal Physiol. 2025 May 01; 328(5):F662-F675. Crespo-Masip M, Goodluck HA, Kim YC, Oe Y, Roach AM, Kanoo S, Lopez N, Zhang H, Badal SS, Vallon V. PMID: 40152436; PMCID: PMC12178309.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism. Am J Physiol Renal Physiol. 2025 Jan 01; 328(1):F68-F81. Kim YC, Das V, Kanoo S, Yao H, Stanford SM, Bottini N, Karihaloo A, Vallon V. PMID: 39589189; PMCID: PMC11918450.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Western diet exacerbates a murine model of Balkan nephropathy. Am J Physiol Renal Physiol. 2025 Jan 01; 328(1):F15-F28. Oe Y, Kim YC, Kanoo S, Goodluck HA, Lopez N, Diedrich J, Pinto AM, Evensen KG, Currais AJM, Maher P, Vallon V. PMID: 39508839; PMCID: PMC11918359.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Deletion, but Not Heterozygosity, of eNOS Raises Blood Pressure and Aggravates Nephropathy in BTBR ob/ob Mice. Nephron. 2024; 148(9):631-642. Kanoo S, Goodluck H, Kim YC, Garrido AN, Crespo-Masip M, Lopez N, Zhang H, Gonzalez-Villalobos RA, Ma LJ, Vallon V. PMID: 38301618; PMCID: PMC11291698.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Metabolic Communication by SGLT2 Inhibition. Circulation. 2024 03 12; 149(11):860-884. Billing AM, Kim YC, Gullaksen S, Schrage B, Raabe J, Hutzfeldt A, Demir F, Kovalenko E, Lassé M, Dugourd A, Fallegger R, Klampe B, Jaegers J, Li Q, Kravtsova O, Crespo-Masip M, Palermo A, Fenton RA, Hoxha E, Blankenberg S, Kirchhof P, Huber TB, Laugesen E, Zeller T, Chrysopoulou M, Saez-Rodriguez J, Magnussen C, Eschenhagen T, Staruschenko A, Siuzdak G, Poulsen PL, Schwab C, Cuello F, Vallon V, Rinschen MM. PMID: 38152989; PMCID: PMC10922673.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    7. SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy. Am J Physiol Renal Physiol. 2024 02 01; 326(2):F227-F240. Oe Y, Kim YC, Sidorenko VS, Zhang H, Kanoo S, Lopez N, Goodluck HA, Crespo-Masip M, Vallon V. PMID: 38031729; PMCID: PMC11198975.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    8. Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function. Am J Physiol Renal Physiol. 2023 06 01; 324(6):F544-F557. Kim YC, Fattah H, Fu Y, Nespoux J, Vallon V. PMID: 37102688; PMCID: PMC10228677.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19). Am J Physiol Renal Physiol. 2022 10 01; 323(4):F455-F467. Navarro Garrido A, Kim YC, Oe Y, Zhang H, Crespo-Masip M, Goodluck HA, Kanoo S, Sanders PW, Bröer S, Vallon V. PMID: 35979966; PMCID: PMC9484999.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    10. Protecting the Kidney: The Unexpected Logic of Inhibiting a Glucose Transporter. Clin Pharmacol Ther. 2022 09; 112(3):434-438. Vallon V, Kim YC. PMID: 35689828.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration. Kidney Int. 2022 03; 101(3):541-550. Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. PMID: 34843754; PMCID: PMC8863629.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    12. A role for tubular Na+/H+ exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol. 2020 10 01; 319(4):F712-F728. Onishi A, Fu Y, Patel R, Darshi M, Crespo-Masip M, Huang W, Song P, Freeman B, Kim YC, Soleimani M, Sharma K, Thomson SC, Vallon V. PMID: 32893663; PMCID: PMC7642886.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    13. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome. Nephron. 2020; 144(8):400-412. Kim YC, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, Dhar D, Vallon V. PMID: 32629454; PMCID: PMC8011852.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Gene knockout of the Na+-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion. Am J Physiol Renal Physiol. 2020 05 01; 318(5):F1100-F1112. Nespoux J, Patel R, Zhang H, Huang W, Freeman B, Sanders PW, Kim YC, Vallon V. PMID: 32116018; PMCID: PMC7294332.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    15. Effect of renal tubule-specific knockdown of the Na+/H+ exchanger NHE3 in Akita diabetic mice. Am J Physiol Renal Physiol. 2019 08 01; 317(2):F419-F434. Onishi A, Fu Y, Darshi M, Crespo-Masip M, Huang W, Song P, Patel R, Kim YC, Nespoux J, Freeman B, Soleimani M, Thomson S, Sharma K, Vallon V. PMID: 31166707; PMCID: PMC6732454.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    16. Knockout of Na+-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration. Am J Physiol Renal Physiol. 2019 07 01; 317(1):F207-F217. Song P, Huang W, Onishi A, Patel R, Kim YC, van Ginkel C, Fu Y, Freeman B, Koepsell H, Thomson S, Liu R, Vallon V. PMID: 31091127; PMCID: PMC6692722.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    17. Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion. Am J Physiol Renal Physiol. 2019 06 01; 316(6):F1201-F1210. Nespoux J, Patel R, Hudkins KL, Huang W, Freeman B, Kim YC, Koepsell H, Alpers CE, Vallon V. PMID: 30995111; PMCID: PMC6620597.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    18. Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart. Hum Gene Ther. 2019 01; 30(1):10-20. Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn MW, Biessen EAL, Hammond HK. PMID: 30003813; PMCID: PMC6343192.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC Basic Transl Sci. 2018 Apr; 3(2):249-264. Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn WM, Biessen E, Hammond HK. PMID: 30062211; PMCID: PMC6059348.
      View in: PubMed   Mentions: 14  
    20. Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation. PLoS One. 2017; 12(8):e0181282. Gao MH, Lai NC, Giamouridis D, Kim YC, Guo T, Hammond HK. PMID: 28767701; PMCID: PMC5540275.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation. JACC Basic Transl Sci. 2016 Dec; 1(7):617-629. Gao MH, Lai NC, Giamouridis D, Kim YC, Tan Z, Guo T, Dillmann WH, Suarez J, Hammond HK. PMID: 28670631; PMCID: PMC5490496.
      View in: PubMed   Mentions: 10  
    22. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 09 22; 1(15):e88322. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. PMID: 27699250; PMCID: PMC5033760.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 2015 Aug 13; 162(4):780-94. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. PMID: 26276632; PMCID: PMC4538707.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansAnimalsCells
    24. Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice. Hum Gene Ther. 2015 Jun; 26(6):347-56. Lai NC, Gao MH, Giamouridis D, Suarez J, Miyanohara A, Parikh J, Hightower S, Guo T, Dillmann W, Kim YC, Diaz-Juarez J, Hammond HK. PMID: 25760560; PMCID: PMC4492611.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015 Apr; 17(4):500-10. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan KL. PMID: 25751140; PMCID: PMC4380774.
      View in: PubMed   Mentions: 335     Fields:    Translation:HumansAnimalsCells
    26. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015 Jan 09; 347(6218):194-8. Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. PMID: 25567907; PMCID: PMC4384888.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansAnimalsCells
    27. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015 Jan; 125(1):25-32. Kim YC, Guan KL. PMID: 25654547; PMCID: PMC4382265.
      View in: PubMed   Mentions: 1026     Fields:    Translation:HumansAnimals
    28. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. PMID: 25457612; PMCID: PMC4303546.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    29. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014 Jul 01; 5:4241. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. PMID: 24980141; PMCID: PMC4100214.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    30. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. PMID: 24882516; PMCID: PMC4075337.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansAnimalsCells
    31. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013 Jan 17; 152(1-2):290-303. Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL. PMID: 23332761; PMCID: PMC3587159.
      View in: PubMed   Mentions: 451     Fields:    Translation:AnimalsCells
    32. Wnt4 is not sufficient to induce lobuloalveolar mammary development. BMC Dev Biol. 2009 Oct 30; 9:55. Kim YC, Clark RJ, Pelegri F, Alexander CM. PMID: 19878558; PMCID: PMC2777140.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    33. Wnt signaling can substitute for estrogen to induce division of ERalpha-positive cells in a mouse mammary tumor model. Cancer Lett. 2010 Mar 01; 289(1):23-31. Mastroianni M, Kim S, Kim YC, Esch A, Wagner C, Alexander CM. PMID: 19665836; PMCID: PMC2874254.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    34. Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effector. Cancer Res. 2008 Dec 15; 68(24):10145-53. Kim YC, Clark RJ, Ranheim EA, Alexander CM. PMID: 19074881; PMCID: PMC2827297.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation. Oncogene. 2003 Dec 18; 22(58):9243-53. Liu BY, Kim YC, Leatherberry V, Cowin P, Alexander CM. PMID: 14681683.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    36. Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis. Oncogene. 2001 Jan 04; 20(1):16-23. Kim YC, Song KS, Yoon G, Nam MJ, Ryu WS. PMID: 11244501.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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