Loading...

Hyam Leffert

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0636
La Jolla CA 92093
Phone8/5-34--2354
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of Rochester, Rochester, NYB.A., Cum laude 1965Intellectual History
    Brandeis University, Waltham, MAM.A.1967Biology
    Albert Einstein College of Medicine, Bronx, NYCM.D.1971Medicine
    University of California at San Diego, La Jolla, CAInternship1971Department of Pediatrics
    Oxford University, Oxford, UKMolecular Cancer Genetics1987Sir William Dunn School of Pathology
    Collapse Awards and Honors
    1st Department of Medicine, University of Tokyo1988Honorary International Guest Speaker, Plenary Lectureship "Liver Regeneration and Gene Therapy
    1987American Men and Women of Science
    John Simon Guggenheim Foundation1987  - 1988John Simon Guggenheim Memorial Fellowship
    American Gastroenterological Association1987  - 1988Morton Grossman Research Scholar Award
    CIBA Foundation Symposium, London 1977State of the Art Lecture
    American Association for the Study of Liver Diseases 1976State of the Art Lecture
    Damon Runyon Cancer Memorial Foundation 1972  - 1973Fellow
    National Cancer Institute 1971  - 1972Fellow

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Fate-mapping temporally marked precursor populations to hepatocellular carcinoma
    NIH/NCI R21CA161510Jun 1, 2012 - May 31, 2014
    Role: Principal Investigator
    IKKbeta:Bi-Functional Regulator of Hepatocyte Proliferation
    NIH/NCI R01CA113602Aug 31, 2007 - May 31, 2012
    Role: Principal Investigator
    Properties of Immune-Privileged STO-Progenitor Cells
    NIH/NIAID R21AI067354Jul 15, 2007 - Jun 30, 2010
    Role: Principal Investigator
    National Flow Cytometry and Sorting Research Resource
    NIH P41RR001315Jul 1, 1982 - Mar 31, 2013
    Role: Co-Investigator
    ISOLATION AND ACTION OF ADULT HEPATOCYTE MITOGENS
    NIH/NIDDK R01DK028215Dec 1, 1980 - Jun 30, 1993
    Role: Principal Investigator
    "ISOLATION AND ACTION OF ADULT RAT HEPATOCYTE MITOGENS"
    NIH/NIADDK R01AM028215Dec 1, 1980 - Nov 30, 1986
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Erratum to "N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems" and "High-Affinity Low-Capacity and Low-Affinity High-Capacity N-Acetyl-2-Aminofluorene (AAF) Macromolecular Binding Sites Are Revealed During the Growth Cycle of Adult Rat Hepatocytes in Primary Culture". Toxicol Sci. 2018 05 25. Koch KS, Moran T, Shier WT, Leffert HL. PMID: 29846706.
      View in: PubMed   Mentions:    Fields:    
    2. N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems. Toxicol Sci. 2018 05 01; 163(1):26-34. Koch KS, Moran T, Shier WT, Leffert HL. PMID: 29319795.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. High-Affinity Low-Capacity and Low-Affinity High-Capacity N-Acetyl-2-Aminofluorene (AAF) Macromolecular Binding Sites Are Revealed During the Growth Cycle of Adult Rat Hepatocytes in Primary Culture. Toxicol Sci. 2018 05 01; 163(1):35-44. Koch KS, Moran T, Shier WT, Leffert HL. PMID: 29319817.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics, First Edition. Edited by Tarik Regad, Thomas J. Sayers and Robert C. Rees. Basic Science of Liver Cancer Stem Cells and Hepatocarcinogenesis. 2015; 273-304. Katherine S. Koch and Hyam L. Leffert.. View Publication.
    5. Ectopic expression of CD74 in Ikkß-deleted mouse hepatocytes. Acta Histochem. 2011 Jul; 113(4):428-35. Koch KS, Leffert HL. PMID: 20569972.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010 Mar 16; 17(3):286-97. He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. PMID: 20227042.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    7. Hypothesis: Targeted Ikkß deletion upregulates MIF signaling responsiveness and MHC class II expression in mouse hepatocytes. Hepat Med. 2010 Mar; 2010(2):39-47. Koch KS, Leffert HL. PMID: 23997575.
      View in: PubMed   Mentions:
    8. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):349-54. Koch KS, Maeda S, He G, Karin M, Leffert HL. PMID: 19171122.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Liver cancer stem cells. J Clin Oncol. 2008 Jun 10; 26(17):2800-5. Sell S, Leffert HL. PMID: 18539957.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    10. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 2006 Sep; 119(1):98-115. Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. PMID: 16836618.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005 Jul 01; 121(7):977-90. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. PMID: 15989949.
      View in: PubMed   Mentions: 402     Fields:    Translation:AnimalsCells
    12. Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats. Stem Cells. 2005 Feb; 23(2):186-99. Zhang M, Joseph B, Gupta S, Guest I, Xu M, Sell S, Son KH, Koch KS, Leffert HL. PMID: 15671142.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Derivation and study of human epithelial cell lines resistant to killing by chromium trioxide. J Toxicol Environ Health A. 2004 Jul 09; 67(13):1027-49. Son KH, Zhang M, Rucobo E, Nwaigwe D, Montgomery F, Leffert H. PMID: 15205032.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Unexpected artifacts raise new caution in stem cell culture research. Hepatology. 2004 Jan; 39(1):258. Leffert HL, Sell S. PMID: 14752846.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 2003 Nov; 19(5):725-37. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. PMID: 14614859.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    16. Hepatic progenitor cell lines from allyl alcohol-treated adult rats are derived from gamma-irradiated mouse STO cells. Stem Cells. 2003; 21(4):449-58. Zhang M, Sell S, Leffert HL. PMID: 12832698.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Derivation, characterization, and phenotypic variation of hepatic progenitor cell lines isolated from adult rats. Hepatology. 2002 Feb; 35(2):315-24. Yin L, Sun M, Ilic Z, Leffert HL, Sell S. PMID: 11826404.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    18. Functional pleiotropy of an intramolecular triplex-forming fragment from the 3'-UTR of the rat Pigr gene. Physiol Genomics. 2001 Mar 08; 5(2):53-65. Fabregat I, Koch KS, Aoki T, Atkinson AE, Dang H, Amosova O, Fresco JR, Schildkraut CL, Leffert HL. PMID: 11242589.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Site-specific integration of targeted DNA into animal cell genomes. Gene. 2000 May 16; 249(1-2):135-44. Koch KS, Aoki T, Wang Y, Atkinson AE, Gleiberman AS, Glebov OK, Leffert HL. PMID: 10831847.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Application of green fluorescent protein-protein A fusion protein to western blotting. Methods Enzymol. 1999; 302:264-72. Aoki T, Koch KS, Leffert HL, Watabe H. PMID: 12876778.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Giant hairpins formed by CUG repeats in myotonic dystrophy messenger RNAs might sterically block RNA export through nuclear pores. J Theor Biol. 1998 Jun 21; 192(4):505-14. Koch KS, Leffert HL. PMID: 9680723.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. A simple and rapid immunoassay system using green fluorescent protein tag. J Immunoassay. 1997 Nov; 18(4):321-33. Aoki T, Kaneta M, Onagi H, Takahashi Y, Koch KS, Leffert HL, Watabe H. PMID: 9358339.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    23. Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene. J Mol Biol. 1997 Mar 28; 267(2):229-36. Aoki T, Koch KS, Leffert HL. PMID: 9096221.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    24. Construction of a fusion protein between protein A and green fluorescent protein and its application to western blotting. FEBS Lett. 1996 Apr 15; 384(2):193-7. Aoki T, Takahashi Y, Koch KS, Leffert HL, Watabe H. PMID: 8612822.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. Hepatic Na(+)-K(+)-ATPase enzyme activity correlates with polarized beta-subunit expression. Am J Physiol. 1995 Jul; 269(1 Pt 1):C69-84. Simon FR, Leffert HL, Ellisman M, Iwahashi M, Deerinck T, Fortune J, Morales D, Dahl R, Sutherland E. PMID: 7631761.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene. Nucleic Acids Res. 1995 Apr 11; 23(7):1098-112. Koch KS, Gleiberman AS, Aoki T, Leffert HL, Feren A, Jones AL, Fodor EJ. PMID: 7739889.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest. 1995 Feb; 95(2):803-10. Westwick JK, Weitzel C, Leffert HL, Brenner DA. PMID: 7860764.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. Primary rat hepatocytes express cyclin D1 messenger RNA during their growth cycle and during mitogenic transitions induced by transforming growth factor-alpha. Biochem Biophys Res Commun. 1994 Oct 14; 204(1):91-7. Koch KS, Lu XP, Leffert HL. PMID: 7945397.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. A 43-base-pair complementary DNA sequence homology and triplet repeat motif among putative polymeric immunoglobulin receptor messenger RNAs in regenerating rat liver. Hepatology. 1993 Jul; 18(1):226-8. Koch KS, Fletcher RG, Grond MP, Leffert HL. PMID: 8325615.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    30. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Cancer Res. 1993 May 15; 53(10 Suppl):2279-86. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP, Brenner DA, Leffert HL. PMID: 8485714.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. Activation of activating protein 1 during hepatic acute phase response. Am J Physiol. 1993 Jan; 264(1 Pt 1):G95-103. Hattori M, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. PMID: 8430810.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    32. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):184-92. Koch KS, Lu XP, Brenner DA, Leffert HL. PMID: 1543489.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration. J Biol Chem. 1992 Feb 15; 267(5):2841-4. Lu XP, Koch KS, Lew DJ, Dulic V, Pines J, Reed SI, Hunter T, Leffert HL. PMID: 1310673.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    34. Induction of sodium pump beta 1-subunit mRNA expression during hepatocellular growth transitions in vitro and in vivo. J Biol Chem. 1991 May 15; 266(14):9276-84. Lu XP, Leffert HL. PMID: 1851173.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. Retroviral vector infection and transplantation in rats of primary fetal rat hepatocytes. J Cell Sci. 1991 May; 99 ( Pt 1):121-30. Koch KS, Brownlee GG, Goss SJ, Martinez-Conde A, Leffert HL. PMID: 1661741.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. Mitogens and hepatocyte growth control in vivo and in vitro. In Vitro Cell Dev Biol. 1990 Nov; 26(11):1011-23. Koch KS, Lu XP, Brenner DA, Fey GH, Martinez-Conde A, Leffert HL. PMID: 2276991.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Expression of collagen genes in the liver. Mol Biol Med. 1990 Apr; 7(2):105-15. Brenner DA, Alcorn JM, Feitelberg SP, Leffert HL, Chojkier M. PMID: 2342427.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    38. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Mol Cell Biol. 1990 Feb; 10(2):689-95. Rippe RA, Brenner DA, Leffert HL. PMID: 2105458.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    39. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Adv Second Messenger Phosphoprotein Res. 1990; 24:352-8. Leffert HL, Koch KS, Lu XP, Brenner DA, Karin M, Skelly HF, Rippe RA, Fey G, Chojkier M. PMID: 2169815.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    40. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. J Biol Chem. 1989 Jun 05; 264(16):9583-91. Chojkier M, Brenner DA, Leffert HL. PMID: 2542314.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    41. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. DNA. 1989 May; 8(4):279-85. Brenner DA, Koch KS, Leffert HL. PMID: 2504570.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    42. Do transplanted human livers regenerate? Hepatology. 1989 May; 9(5):789-90. Koch KS, Leffert HL. PMID: 2651271.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Biochemical localization of hepatic surface-membrane Na+,K+-ATPase activity depends on membrane lipid fluidity. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8673-7. Sutherland E, Dixon BS, Leffert HL, Skally H, Zaccaro L, Simon FR. PMID: 2847169.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    44. Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somat Cell Mol Genet. 1987 Jul; 13(4):423-8. Wolff JA, Yee JK, Skelly H, Moores J, Respess J, Friedmann T, Leffert H. PMID: 3484086.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A. 1987 May; 84(10):3344-8. Wolff JA, Yee JK, Skelly HF, Moores JC, Respess JG, Friedmann T, Leffert H. PMID: 3033644.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    46. Rat hepatic (Na+, K+)-ATPase: alpha-subunit isolation by immunoaffinity chromatography and structural analysis by peptide mapping. Biochemistry. 1986 Jul 15; 25(14):4156-63. Hubert JJ, Schenk DB, Skelly H, Leffert HL. PMID: 3017414.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes. J Biol Chem. 1986 Jun 15; 261(17):7929-33. Kruijer W, Skelly H, Botteri F, van der Putten H, Barber JR, Verma IM, Leffert HL. PMID: 3711118.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    48. Hepatic (Na+,K+)-ATPase: a current view of its structure, function and localization in rat liver as revealed by studies with monoclonal antibodies. Hepatology. 1985 May-Jun; 5(3):501-7. Leffert HL, Schenk DB, Hubert JJ, Skelly H, Schumacher M, Ariyasu R, Ellisman M, Koch KS, Keller GA. PMID: 2987099.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    49. Use of a monoclonal antibody to quantify (Na+,K+)-ATPase activity and sites in normal and regenerating rat liver. J Biol Chem. 1984 Dec 10; 259(23):14941-51. Schenk DB, Hubert JJ, Leffert HL. PMID: 6094583.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Inhibitory monoclonal antibodies against rat liver alcohol dehydrogenase. Arch Biochem Biophys. 1984 Dec; 235(2):589-95. Lad PJ, Schenk DB, Leffert HL. PMID: 6393880.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    51. Developmental changes in rat liver alcohol dehydrogenase. Dev Biol. 1984 Oct; 105(2):526-9. Lad PJ, Shoemaker WJ, Leffert HL. PMID: 6383901.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    52. Changes in adenylate cyclase and phosphodiesterase activities during the growth cycle of adult rat hepatocytes in primary culture. Arch Biochem Biophys. 1984 Aug 01; 232(2):679-84. Lad PJ, Blazquez E, Lin M, Leffert HL. PMID: 6087736.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    53. Initiation of cultured rat hepatocyte proliferation does not involve Na+-dependent plasma membrane Ca2+ fluxes. Cell Biol Int Rep. 1984 Apr; 8(4):309-16. Koch KS, Grosse R, Skelly H, Leffert HL. PMID: 6329528.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    54. Rat liver alcohol dehydrogenase. I. Purification and characterization. Anal Biochem. 1983 Sep; 133(2):350-61. Lad PJ, Leffert HL. PMID: 6356985.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    55. Rat liver alcohol dehydrogenase. II. Quantitative enzyme-linked immunoadsorbent assay. Anal Biochem. 1983 Sep; 133(2):362-72. Lad PJ, Leffert HL. PMID: 6356986.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    56. Monoclonal antibodies to rat Na+,K+-ATPase block enzymatic activity. Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5281-5. Schenk DB, Leffert HL. PMID: 6310568.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    57. Selective effects of portal blood diversion and glucagon on rat hepatocyte rates of S-phase entry and deoxyribonucleic acid synthesis. Endocrinology. 1983 Apr; 112(4):1224-32. de Hemptinne B, Leffert HL. PMID: 6339201.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    58. Comparison of liver alcohol dehydrogenases in Fischer-344 and Sprague-Dawley rats. Comp Biochem Physiol B. 1983; 75(2):373-8. Lad PJ, Hubert JJ, Shoemaker WJ, Leffert HL. PMID: 6347508.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    59. Expression of differentiated function by hepatocytes in primary culture: variable effects of glucagon and insulin on gluconeogenesis during cell growth. Differentiation. 1983; 25(2):176-84. Brown JW, Lad PJ, Skelly H, Koch KS, Lin M, Leffert H. PMID: 6363185.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    60. Rat hepatocyte proliferation is stimulated by insulin-like peptides in defined medium. Biochem Biophys Res Commun. 1982 Dec 15; 109(3):1054-60. Koch KS, Shapiro P, Skelly H, Leffert HL. PMID: 6297482.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    61. Amiloride blocks cell-free protein synthesis at levels attained inside cultured rat hepatocytes. Biochem Biophys Res Commun. 1982 Sep 30; 108(2):738-45. Leffert HL, Koch KS, Fehlmann M, Heiser W, Lad PJ, Skelly H. PMID: 7150320.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    62. (Na+,K+)-ATPase: a new assay of Na+-ATPase reveals covert anti-pump antibodies. Anal Biochem. 1982 Sep 01; 125(1):189-96. Schenk DB, Grosse R, Ellisman MH, Bradshaw V, Leffert HL. PMID: 6128943.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    63. An evaluation of cellular lineages in the pathogenesis of experimental hepatocellular carcinoma. Hepatology. 1982 Jan-Feb; 2(1):77-86. Sell S, Leffert HL. PMID: 6172353.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    64. Adult rat hepatocytes in primary culture. VI. Developmental changes in alcohol dehydrogenase activity and ethanol conversion during the growth cycle. Alcohol Clin Exp Res. 1982; 6(1):64-71. Lad PJ, Shier WT, Skelly H, De Hemptinne B, Leffert HL. PMID: 7041687.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    65. Adult rat hepatocytes in primary culture. VII. Proliferative and functional properties of cells from ethanol-intoxicated animals: evidence for a reversible albumin 'production defect'. Alcohol Clin Exp Res. 1982; 6(1):72-9. Lad PJ, Shier WT, Skelly H, de Hemptinne B, Leffert HL. PMID: 7041688.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    66. Rapid development of large numbers of alpha-fetoprotein-containing "oval" cells in the liver of rats fed N-2-fluorenylacetamide in a choline-devoid diet. Gan. 1981 Aug; 72(4):479-87. Sell S, Leffert HL, Shinozuka H, Lombardi B, Gochman N. PMID: 6171471.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    67. The effect of amiloride on hormonal regulation of amino acid transport in isolated and cultured adult rat hepatocytes. Biochim Biophys Acta. 1981 Mar 20; 642(1):88-95. Fehlmann M, Samson M, Koch KS, Leffert HL, Freychet P. PMID: 6261811.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    68. Amiloride inhibits protein synthesis in isolated rat hepatocytes. Life Sci. 1981 Mar 16; 28(11):1295-302. Fehlmann M, Samson M, Koch KS, Leffert HL, Freychet P. PMID: 6164897.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    69. Autoradiography of "oval cells" appearing rapidly in the livers of rats fed N-2-fluorenylacetamide in a choline devoid diet. Carcinogenesis. 1981; 2(1):7-14. Sell S, Osborn K, Leffert HL. PMID: 7273292.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    70. Rapid radioisotopic analysis of glucose synthesis from lactate in primary hepatocyte cultures. Anal Biochem. 1980 Dec; 109(2):284-90. Brown JW, Leffert HL, Sell S, Ho RJ. PMID: 7013563.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    71. Growth control of differentiated adult rat hepatocytes in primary culture. Ann N Y Acad Sci. 1980; 349:111-27. Koch KS, Leffert HL. PMID: 7013607.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    72. Ionic events at the membrane initiate rat liver regeneration. Ann N Y Acad Sci. 1980; 339:201-15. Leffert HL, Koch KS. PMID: 6930831.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    73. Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation. Cell. 1979 Sep; 18(1):153-63. Koch KS, Leffert HL. PMID: 509519.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    74. Hormonal control of rat liver regeneration. Gastroenterology. 1979 Jun; 76(6):1470-82. Leffert HL, Koch KS, Moran T, Rubalcava B. PMID: 220134.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    75. Ionic landmarks along the mitogenic route. Nature. 1979 May 10; 279(5709):104-5. Koch KS, Leffert HL. PMID: 35752.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    76. Liver cells. Methods Enzymol. 1979; 58:536-44. Leffert HL, Koch KS, Moran T, Williams M. PMID: 423789.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    77. Regulation of growth of hepatocytes by sodium ions. Prog Liver Dis. 1979; 6:123-34. Leffert HL, Koch KS. PMID: 396552.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    78. Hepatocyte growth control: in vitro approach to problems of liver regeneration and function. Natl Cancer Inst Monogr. 1978 May; (48):87-101. Leffert HL, Koch KS, Rubalcava B, Sell S, Moran T, Boorstein R. PMID: 219365.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    79. Growth state-dependent phenotypes of adult hepatocytes in primary monolayer culture. Proc Natl Acad Sci U S A. 1978 Apr; 75(4):1834-8. Leffert H, Moran T, Sell S, Skelly H, Ibsen K, Mueller M, Arias I. PMID: 77017.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    80. Procarcinogen activation and hormonal control of cell proliferation in differentiated primary adult rat liver cell cultures. Nature. 1977 May 05; 267(5606):58-61. Leffert HL, Moran T, Boorstein R, Koch KS. PMID: 558527.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    81. Proliferation of hepatocytes. Ciba Found Symp. 1977; (55):61-82. Leffert HL, Koch KS. PMID: 77757.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    82. Expression of an oncodevelopmental gene product (alpha-fetoprotein) during fetal development and adult oncogenesis. Cancer Res. 1976 Nov; 36(11 Pt. 2):4239-49. Sell S, Becker FF, Leffert HL, Watabe L. PMID: 61804.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    83. Present paradoxes in the environmental control of hepatic proliferation. Cancer Res. 1976 Nov; 36(11 Pt. 2):4250-5. Leffert HL, Koch KS, Rubalcava B. PMID: 184931.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    84. Control of hepatic proliferation: a working hypothesis involving hormones, lipoproteins, and novel nucleotides. Metabolism. 1976 Nov; 25(11 Suppl 1):1419-22. Koch KS, Leffert HL. PMID: 185496.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    85. Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. IX. Specific inhibition of DNA synthesis initiation by very low density lipoprotein and possible significance to the problem of liver regeneration. J Cell Biol. 1976 Jul; 70(1):20-32. Leffert HL, Weinstein DB. PMID: 180032.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    86. Thyroid hormone metabolism during liver regeneration in rats. Endocrinology. 1976 May; 98(5):1241-7. Leffert HL, Alexander NM. PMID: 1261517.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    87. Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats. Proc Natl Acad Sci U S A. 1975 Oct; 72(10):4033-6. Leffert H, Alexander NM, Faloona G, Rubalcava B, Unger R. PMID: 172891.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    88. Relationship of the biosynthesis of alpha-fetoprotein, albumin, hemopexin, and haptoglobin to the growth state of fetal rat hepatocyte cultures. Ann N Y Acad Sci. 1975 Aug 22; 259:45-58. Sell S, Skelly H, Leffert HL, Muller-Eberhard U, Kida S. PMID: 54037.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    89. Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. V. Occurrence in dialyzed fetal bovine serum of macromolecules having both positive and negative growth regulatory functions. J Cell Biol. 1974 Sep; 62(3):767-79. Leffert HL. PMID: 4859343.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    90. Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. VII. Hormonal control of DNA synthesis and its possible significance to the problem of liver regeneration. J Cell Biol. 1974 Sep; 62(3):792-801. Leffert HL. PMID: 4859345.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    91. Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. VI. Studies with conditioned medium and its functional interactions with serum factors. J Cell Biol. 1974 Sep; 62(3):780-91. Koch K, Leffert HL. PMID: 4859344.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    92. Alpha1-fetoprotein biosynthesis during the growth cycle of differentiated fetal rat hepatocytes in primary monolayer culture. J Cell Biol. 1974 Jun; 61(3):823-9. Leffert HL, Sell S. PMID: 4134464.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    93. Hepatocyte proliferation and alpha 1-fetoprotein in pregnant, neonatal, and partially hepatectomized rats. Cancer Res. 1974 Apr; 34(4):865-71. Sell S, Nichols M, Becker FF, Leffert HL. PMID: 4814999.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    94. Serum dependent growth of primary cultured differentiated fetal rat hepatocytes in arginine-deficient medium. J Cell Physiol. 1973 Feb; 81(1):113-24. Leffert HL, Paul D. PMID: 4568374.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    95. Studies on primary cultures of differentiated fetal liver cells. J Cell Biol. 1972 Mar; 52(3):559-68. Leffert HL, Paul D. PMID: 4333210.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    96. Stimulation of DNA and protein synthesis in fetal-rat liver cells by serum from partially hepatectomized rats. Proc Natl Acad Sci U S A. 1972 Feb; 69(2):374-7. Paul D, Leffert H, Sato G, Holley RW. PMID: 4501120.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    97. Enrichment culture techniques for selection of cell culture strains with desirable physiological and genetic properties. Acta Endocrinol Suppl (Copenh). 1971; 153:126-36. Sato G, Clark J, Posner M, Leffert H, Paul D, Morgan M, Colby C. PMID: 4325482.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    98. Meningitis and bacteremia after ventriculoatrial shunt-revision: isolation of a lecithinase-producing Bacillus cereus. J Infect Dis. 1970 Dec; 122(6):547-52. Leffert HL, Baptist JN, Gidez LI. PMID: 4992341.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    99. Genetic mapping of a defective bacteriophage on the chromosome of Bacillus subtilis 168. J Virol. 1970 Sep; 6(3):340-3. Garro AJ, Leffert H, Marmur J. PMID: 4991424.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    Hyam's Networks
    Concepts (438)
    Derived automatically from this person's publications.
    _
    Co-Authors (6)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _