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Conserved metabolic enzymes as vaccine antigens for giardiasis. PLoS Negl Trop Dis. 2022 Apr; 16(4):e0010323.
Ihara S, Miyamoto Y, Le CHY, Tran VN, Hanson EM, Fischer M, Hanevik K, Eckmann L. PMID: 35468132; PMCID: PMC9037923.
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Co-Delivery of Antigens and Adjuvant in Polymeric Nanoparticles Coated with Native Parasite Membranes Induces Protective Mucosal Immunity against Giardia lamblia. J Infect Dis. 2022 Mar 09.
Zhou J, Miyamoto Y, Ihara S, Kroll AV, Nieskens N, Tran VN, Hanson EM, Fang RH, Zhang L, Eckmann L. PMID: 35262728.
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Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics. Front Microbiol. 2022; 13:834008.
Krakovka S, Ribacke U, Miyamoto Y, Eckmann L, Svärd S. PMID: 35222342; PMCID: PMC8866875.
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Colesevelam ameliorates non-alcoholic steatohepatitis and obesity in mice. Hepatol Int. 2022 Apr; 16(2):359-370.
Hartmann P, Duan Y, Miyamoto Y, Demir M, Lang S, Hasa E, Stern P, Yamashita D, Conrad M, Eckmann L, Schnabl B. PMID: 35075592; PMCID: PMC9013343.
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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Science. 2022 Jan 14; 375(6577):214-221.
Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K. PMID: 35025664.
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The fecal mycobiome in non-alcoholic fatty liver disease. J Hepatol. 2022 Apr; 76(4):788-799.
Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Stärkel P, Fouts DE, Schnabl B. PMID: 34896404; PMCID: PMC8981795.
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Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter. Mol Microbiol. 2021 12; 116(6):1489-1511.
Natto MJ, Miyamoto Y, Munday JC, AlSiari TA, Al-Salabi MI, Quashie NB, Eze AA, Eckmann L, De Koning HP. PMID: 34738285; PMCID: PMC8688338.
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K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors. Sci Rep. 2021 10 19; 11(1):20658.
Tago K, Ohta S, Aoki-Ohmura C, Funakoshi-Tago M, Sashikawa M, Matsui T, Miyamoto Y, Wada T, Oshio T, Komine M, Matsugi J, Furukawa Y, Ohtsuki M, Yamauchi J, Yanagisawa K. PMID: 34667224; PMCID: PMC8526694.
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PubMed Mentions:
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Deazapurine Nucleoside Analogues for the Treatment of Trichomonas vaginalis. ACS Infect Dis. 2021 06 11; 7(6):1752-1764.
Natto MJ, Hulpia F, Kalkman ER, Baillie S, Alhejeli A, Miyamoto Y, Eckmann L, Van Calenbergh S, de Koning HP. PMID: 33974405.
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Translation:
HumansAnimals
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Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in Trichomonas vaginalis. J Med Chem. 2021 05 27; 64(10):6608-6620.
Miyamoto Y, Aggarwal S, Celaje JJA, Ihara S, Ang J, Eremin DB, Land KM, Wrischnik LA, Zhang L, Fokin VV, Eckmann L. PMID: 33974434.
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HumansAnimalsCells
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Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods. Mol Biol Cell. 2021 04 15; 32(8):769-787.
Miyamoto Y, Torii T, Terao M, Takada S, Tanoue A, Katoh H, Yamauchi J. PMID: 33596091; PMCID: PMC8108512.
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Translation:
AnimalsCells
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Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis. PLoS Negl Trop Dis. 2020 04; 14(4):e0008224.
Lauwaet T, Miyamoto Y, Ihara S, Le C, Kalisiak J, Korthals KA, Ghassemian M, Smith DK, Sharpless KB, Fokin VV, Eckmann L. PMID: 32302296; PMCID: PMC7190177.
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Translation:
AnimalsCells
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Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature. 2019 11; 575(7783):505-511.
Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B. PMID: 31723265; PMCID: PMC6872939.
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PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection. Adv Ther (Weinh). 2019 Dec; 2(12).
Zhang Y, Miyamoto Y, Ihara S, Yang JZ, Zuill DE, Angsantikul P, Zhang Q, Gao W, Zhang L, Eckmann L. PMID: 32377561; PMCID: PMC7202563.
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PubMed Mentions:
3
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20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11).
O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503; PMCID: PMC6811414.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Evaluation of Peroxides and Chlorine Oxides as Disinfectants for Chemical Sterilization of Gnotobiotic Rodent Isolators. J Am Assoc Lab Anim Sci. 2019 09 01; 58(5):558-568.
Moody LV, Miyamoto Y, Ang J, Richter PJ, Eckmann L. PMID: 31319899; PMCID: PMC6774453.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsPHPublic Health
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Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cells. J Physiol Sci. 2019 Sep; 69(5):741-748.
Hashimoto R, Miyamoto Y, Itoh S, Daida H, Okada T, Katoh Y. PMID: 31256364.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia. Infect Immun. 2019 06; 87(6).
Davids BJ, Liu CM, Hanson EM, Le CHY, Ang J, Hanevik K, Fischer M, Radunovic M, Langeland N, Ferella M, Svärd SG, Ghassemian M, Miyamoto Y, Eckmann L. PMID: 30962402; PMCID: PMC6529650.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase. Cell Rep. 2018 09 11; 24(11):2894-2907.
Wang L, Tanaka Y, Wang D, Morikawa M, Zhou R, Homma N, Miyamoto Y, Hirokawa N. PMID: 30208315.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Validation of Babesia proteasome as a drug target. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):394-402.
Jalovecka M, Hartmann D, Miyamoto Y, Eckmann L, Hajdusek O, O'Donoghue AJ, Sojka D. PMID: 30103207; PMCID: PMC6092455.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. PLoS Negl Trop Dis. 2018 02; 12(2):e0006266.
Das S, Angsantikul P, Le C, Bao D, Miyamoto Y, Gao W, Zhang L, Eckmann L. PMID: 29470490; PMCID: PMC5839590.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia. Antimicrob Agents Chemother. 2017 06; 61(6).
Kim WJ, Korthals KA, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L. PMID: 28396548; PMCID: PMC5444119.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo. Int J Antimicrob Agents. 2016 Dec; 48(6):690-694.
Hopper M, Yun JF, Zhou B, Le C, Kehoe K, Le R, Hill R, Jongeward G, Debnath A, Zhang L, Miyamoto Y, Eckmann L, Land KM, Wrischnik LA. PMID: 27839893; PMCID: PMC5154799.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes. J Allergy Clin Immunol. 2017 Apr; 139(4):1205-1216.e6.
Wang Z, Mascarenhas N, Eckmann L, Miyamoto Y, Sun X, Kawakami T, Di Nardo A. PMID: 27746235; PMCID: PMC5385284.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Social isolation impairs remyelination in mice through modulation of IL-6. FASEB J. 2016 12; 30(12):4267-4274.
Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami SI, Yoshino H, Wanaka A, Kishimoto T. PMID: 27613805.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Microbiota and Alcoholic Liver Disease. Alcohol Clin Exp Res. 2016 08; 40(8):1791-2.
Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B. PMID: 27364225.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia. Front Microbiol. 2015; 6:1208.
Miyamoto Y, Eckmann L. PMID: 26635732; PMCID: PMC4652082.
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PubMed Mentions:
14
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Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury. Alcohol Clin Exp Res. 2015 Dec; 39(12):2313-23.
Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B. PMID: 26556636; PMCID: PMC4712135.
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PubMed Mentions:
35 Fields:
Translation:
Animals
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Arf6 mediates Schwann cell differentiation and myelination. Biochem Biophys Res Commun. 2015 Sep 25; 465(3):450-7.
Torii T, Miyamoto Y, Yamamoto M, Ohbuchi K, Tsumura H, Kawahara K, Tanoue A, Sakagami H, Yamauchi J. PMID: 26277388.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. Mol Biol Cell. 2015 Oct 01; 26(19):3489-503.
Miyamoto Y, Torii T, Takada S, Ohno N, Saitoh Y, Nakamura K, Ito A, Ogata T, Terada N, Tanoue A, Yamauchi J. PMID: 26224309; PMCID: PMC4591693.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. Eur J Med Chem. 2015 Aug 28; 101:96-102.
Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA. PMID: 26117821; PMCID: PMC4550478.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia. Exp Parasitol. 2015 Sep; 156:68-78.
Dann SM, Manthey CF, Le C, Miyamoto Y, Gima L, Abrahim A, Cao AT, Hanson EM, Kolls JK, Raz E, Cong Y, Eckmann L. PMID: 26071205; PMCID: PMC4547885.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J. 2015 Mar; 29(3):1043-55.
Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. PMID: 25466902; PMCID: PMC4422368.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44.
Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. PMID: 24820073; PMCID: PMC4068574.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination. Mol Biol Cell. 2014 May; 25(9):1532-42.
Miyamoto Y, Yamamori N, Torii T, Tanoue A, Yamauchi J. PMID: 24600047; PMCID: PMC4004601.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17564-9.
Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L. PMID: 24101497; PMCID: PMC3808650.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells. Cell Signal. 2013 Jun; 25(6):1379-87.
Miyamoto Y, Torii T, Nakamura K, Takashima S, Sanbe A, Tanoue A, Yamauchi J. PMID: 23517829.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Sci Signal. 2013 Mar 05; 6(265):ra15.
Miyamoto Y, Torii T, Yamamori N, Ogata T, Tanoue A, Yamauchi J. PMID: 23462102.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35.
Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. PMID: 23403423; PMCID: PMC3632933.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimals
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The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination. J Neurosci. 2011 Aug 31; 31(35):12579-92.
Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, Tanoue A. PMID: 21880919; PMCID: PMC6703263.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia. Antimicrob Agents Chemother. 2011 Oct; 55(10):4643-51.
Tejman-Yarden N, Millman M, Lauwaet T, Davids BJ, Gillin FD, Dunn L, Upcroft JA, Miyamoto Y, Eckmann L. PMID: 21825286; PMCID: PMC3186953.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. J Med Chem. 2009 Jul 09; 52(13):4038-53.
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L. PMID: 19480409; PMCID: PMC2766634.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20.
Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. PMID: 16818780.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic Escherichia coli signalling of human colon epithelium in vivo. Cell Microbiol. 2006 May; 8(5):869-79.
Miyamoto Y, Iimura M, Kaper JB, Torres AG, Kagnoff MF. PMID: 16611235.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J Immunol. 2005 Apr 15; 174(8):4901-7.
Iimura M, Gallo RL, Hase K, Miyamoto Y, Eckmann L, Kagnoff MF. PMID: 15814717.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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The adaptor protein Nck1 mediates endothelin A receptor-regulated cell migration through the Cdc42-dependent c-Jun N-terminal kinase pathway. J Biol Chem. 2004 Aug 13; 279(33):34336-42.
Miyamoto Y, Yamauchi J, Mizuno N, Itoh H. PMID: 15187089.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8. Cell Microbiol. 2002 Oct; 4(10):635-48.
Berin MC, Darfeuille-Michaud A, Egan LJ, Miyamoto Y, Kagnoff MF. PMID: 12366401.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells