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Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism. J Biol Chem. 2023 05; 299(5):104611.
Trieger GW, Pessentheiner AR, Purcell SC, Green CR, DeForest N, Willert K, Majithia AR, Metallo CM, Godula K, Gordts PLSM. PMID: 36931394; PMCID: PMC10164900.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Wnt signaling and the regulation of pluripotency. Curr Top Dev Biol. 2023; 153:95-119.
Sonavane P, Willert K. PMID: 36967203.
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PubMed Mentions: Fields:
Translation:
Cells
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Preface. Curr Top Dev Biol. 2023; 153:xv-xvi.
Yamaguchi TP, Willert K. PMID: 36967204.
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PubMed Mentions: Fields:
-
Enrichment and Detection of Wnt Proteins from Cell Culture Media. Methods Mol Biol. 2022; 2438:123-131.
Sonavane PR, Willert K. PMID: 35147939.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022 01; 21(1):113-124.
Do M, Wu CCN, Sonavane PR, Juarez EF, Adams SR, Ross J, Rodriguez Y Baena A, Patel C, Mesirov JP, Carson DA, Advani SJ, Willert K. PMID: 34667113; PMCID: PMC8742765.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. N Engl J Med. 2021 09 30; 385(14):1292-1301.
Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, Marshall T, Jiang N, Yang X, McEvoy-Venneri J, Stanley V, Anzenberg P, Lang N, Wazny V, Yu J, Virshup DM, Nygaard R, Mancia F, Merdzanic R, Toralles MBP, Pitanga PML, Puri RD, Hernan R, Chung WK, Bertoli-Avella AM, Al-Sannaa N, Zaki MS, Willert K, Reversade B, Gleeson JG. PMID: 34587386; PMCID: PMC9017221.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically. Handb Exp Pharmacol. 2021; 269:3-28.
Sonavane PR, Willert K. PMID: 34463853.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells. Elife. 2020 12 17; 9.
Gumber D, Do M, Suresh Kumar N, Sonavane PR, Wu CCN, Cruz LS, Grainger S, Carson D, Gaasterland T, Willert K. PMID: 33331818; PMCID: PMC7759383.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nat Cell Biol. 2019 06; 21(6):721-730.
Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon CH, Wozniak JM, Barahona R, Kamei CN, Houston J, Carrillo-Terrazas M, Drummond IA, Gonzalez D, Willert K, Traver D. PMID: 31110287; PMCID: PMC6559346.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of Wnt signaling and control. Wiley Interdiscip Rev Syst Biol Med. 2018 Sep; 10(5):e1422.
Grainger S, Willert K. PMID: 29600540; PMCID: PMC6165711.
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PubMed Mentions:
41 Fields:
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WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development. Genes (Basel). 2018 Jan 29; 9(2).
Richter J, Stanley EG, Ng ES, Elefanty AG, Traver D, Willert K. PMID: 29382179; PMCID: PMC5852562.
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PubMed Mentions:
10 Fields:
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Wnt Signaling in Hematological Malignancies. Prog Mol Biol Transl Sci. 2018 01; 153:321-341.
Grainger S, Traver D, Willert K. PMID: 29389522; PMCID: PMC5972548.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells. Nat Commun. 2017 10 18; 8(1):1034.
Huggins IJ, Bos T, Gaylord O, Jessen C, Lonquich B, Puranen A, Richter J, Rossdam C, Brafman D, Gaasterland T, Willert K. PMID: 29044119; PMCID: PMC5647328.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Wnt/β-catenin signaling during early vertebrate neural development. Dev Neurobiol. 2017 11; 77(11):1239-1259.
Brafman D, Willert K. PMID: 28799266; PMCID: PMC5819875.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017 Jun 06; 10(482).
Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH, Zanetti M. PMID: 28588081; PMCID: PMC5962022.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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The role of Wnt signaling in hematopoietic stem cell development. Crit Rev Biochem Mol Biol. 2017 08; 52(4):414-424.
Richter J, Traver D, Willert K. PMID: 28508727; PMCID: PMC6104630.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017 03 13; 40(5):439-452.e4.
Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, Hamada H. PMID: 28292423; PMCID: PMC7974384.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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CRISPR Guide RNA Validation In Vitro. Zebrafish. 2017 Aug; 14(4):383-386.
Grainger S, Lonquich B, Oon CH, Nguyen N, Willert K, Traver D. PMID: 27829120; PMCID: PMC5549792.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Rep. 2016 11 01; 17(6):1595-1606.
Grainger S, Richter J, Palazón RE, Pouget C, Lonquich B, Wirth S, Grassme KS, Herzog W, Swift MR, Weinstein BM, Traver D, Willert K. PMID: 27806298; PMCID: PMC6309681.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13150-13155.
Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson DA, Lu D. PMID: 27799526; PMCID: PMC5135380.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
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Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016 10; 21(10):1417-33.
Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. PMID: 26830142; PMCID: PMC5685528.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Methods to Manipulate and Monitor Wnt Signaling in Human Pluripotent Stem Cells. Methods Mol Biol. 2016; 1481:161-81.
Huggins IJ, Brafman D, Willert K. PMID: 27590161.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 2015 Nov 10; 4.
Kumar N, Richter J, Cutts J, Bush KT, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K. PMID: 26554899; PMCID: PMC4631902.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife. 2015 Jun 30; 4:e07091.
Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, Ghosh P. PMID: 26126266; PMCID: PMC4484057.
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PubMed Mentions:
70 Fields:
Translation:
HumansCells
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A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells. Cell Rep. 2014 Dec 11; 9(5):1770-1780.
Ross J, Busch J, Mintz E, Ng D, Stanley A, Brafman D, Sutton VR, Van den Veyver I, Willert K. PMID: 25464842; PMCID: PMC4335800.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity. Stem Cell Reports. 2014 Dec 09; 3(6):1015-28.
Moya N, Cutts J, Gaasterland T, Willert K, Brafman DA. PMID: 25458891; PMCID: PMC4264562.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1409-14.
Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson DA, Willert K. PMID: 24474766; PMCID: PMC3910637.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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WNT5A encodes two isoforms with distinct functions in cancers. PLoS One. 2013; 8(11):e80526.
Bauer M, Bénard J, Gaasterland T, Willert K, Cappellen D. PMID: 24260410; PMCID: PMC3832467.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells. Stem Cell Reports. 2013; 1(5):464-78.
Brafman DA, Moya N, Allen-Soltero S, Fellner T, Robinson M, McMillen ZL, Gaasterland T, Willert K. PMID: 24286033; PMCID: PMC3841266.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395.
Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. PMID: 23516471; PMCID: PMC3596392.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013 Mar; 20(3):369-81.
Brafman DA, Phung C, Kumar N, Willert K. PMID: 23154389; PMCID: PMC3569984.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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Wnt proteins. Cold Spring Harb Perspect Biol. 2012 Sep 01; 4(9):a007864.
Willert K, Nusse R. PMID: 22952392; PMCID: PMC3428774.
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PubMed Mentions:
189 Fields:
Translation:
HumansAnimalsCells
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Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations. Nat Protoc. 2012 Mar 15; 7(4):703-17.
Brafman DA, Chien S, Willert K. PMID: 22422316.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol. 2012 Apr 01; 364(1):11-21.
Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush KT, Willert K, Farquhar MG, Nigam SK. PMID: 22290330; PMCID: PMC3310225.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Wnt signaling: the β-cat(enin)'s meow. Genes Dev. 2012 Jan 15; 26(2):105-9.
Bauer M, Willert K. PMID: 22279043; PMCID: PMC3273833.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):370-7.
Mulligan KA, Fuerer C, Ching W, Fish M, Willert K, Nusse R. PMID: 22203956; PMCID: PMC3258625.
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PubMed Mentions:
93 Fields:
Translation:
AnimalsCells
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Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials. 2010 Dec; 31(34):9135-44.
Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. PMID: 20817292; PMCID: PMC2949524.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J Biol Chem. 2010 Apr 30; 285(18):13561-8.
Hu T, Li C, Cao Z, Van Raay TJ, Smith JG, Willert K, Solnica-Krezel L, Coffey RJ. PMID: 20177058; PMCID: PMC2859517.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14; 4(12):e8294.
Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson DA. PMID: 20011538; PMCID: PMC2789382.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev. 2009 Oct; 18(8):1141-54.
Brafman DA, Shah KD, Fellner T, Chien S, Willert K. PMID: 19327010.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med. 2009 Sep; 15(9):1046-54.
Lancaster MA, Louie CM, Silhavy JL, Sintasath L, Decambre M, Nigam SK, Willert K, Gleeson JG. PMID: 19718039; PMCID: PMC2895985.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24.
Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat Biotechnol. 2009 Jun; 27(6):567-71.
Eguchi A, Meade BR, Chang YC, Fredrickson CT, Willert K, Puri N, Dowdy SF. PMID: 19448630; PMCID: PMC2694965.
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PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway. Cell Signal. 2008 Dec; 20(12):2317-23.
Soda M, Willert K, Kaushansky K, Geddis AE. PMID: 18804163; PMCID: PMC2677808.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Isolation and application of bioactive Wnt proteins. Methods Mol Biol. 2008; 468:17-29.
Willert KH. PMID: 19099243.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Wnt signaling: is the party in the nucleus? Genes Dev. 2006 Jun 01; 20(11):1394-404.
Willert K, Jones KA. PMID: 16751178.
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PubMed Mentions:
239 Fields:
Translation:
AnimalsCells
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Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. Dev Dyn. 2006 Mar; 235(3):681-90.
Galli LM, Barnes T, Cheng T, Acosta L, Anglade A, Willert K, Nusse R, Burrus LW. PMID: 16425220; PMCID: PMC2566934.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005 Mar; 6(3):314-22.
Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. PMID: 15665828.
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PubMed Mentions:
317 Fields:
Translation:
HumansAnimalsCells
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A proliferative role for Wnt-3a in chick somites. Dev Biol. 2004 May 15; 269(2):489-504.
Galli LM, Willert K, Nusse R, Yablonka-Reuveni Z, Nohno T, Denetclaw W, Burrus LW. PMID: 15110715.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003 May 22; 423(6938):448-52.
Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. PMID: 12717451.
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PubMed Mentions:
851 Fields:
Translation:
AnimalsCells
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A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003 May 22; 423(6938):409-14.
Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL. PMID: 12717450.
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PubMed Mentions:
737 Fields:
Translation:
AnimalsCells
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The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. Nature. 2001 May 17; 411(6835):325-30.
Wilson SI, Rydström A, Trimborn T, Willert K, Nusse R, Jessell TM, Edlund T. PMID: 11357137.
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PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000 Jul; 13(1):15-24.
Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, Grosschedl R. PMID: 10933391.
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PubMed Mentions:
156 Fields:
Translation:
AnimalsCells
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A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development. 1999 Sep; 126(18):4165-73.
Willert K, Logan CY, Arora A, Fish M, Nusse R. PMID: 10457025.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev. 1999 Jul 15; 13(14):1768-73.
Willert K, Shibamoto S, Nusse R. PMID: 10421629; PMCID: PMC316878.
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PubMed Mentions:
122 Fields:
Translation:
Cells
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WNT signaling in the control of hair growth and structure. Dev Biol. 1999 Mar 01; 207(1):133-49.
Millar SE, Willert K, Salinas PC, Roelink H, Nusse R, Sussman DJ, Barsh GS. PMID: 10049570.
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PubMed Mentions:
106 Fields:
Translation:
AnimalsCells
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Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar; 18(3):1248-56.
Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H. PMID: 9488439; PMCID: PMC108837.
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PubMed Mentions:
123 Fields:
Translation:
HumansAnimalsCells
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Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev. 1998 Feb; 8(1):95-102.
Willert K, Nusse R. PMID: 9529612.
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PubMed Mentions:
190 Fields:
Translation:
HumansAnimalsCells
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Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J. 1997 Jun 02; 16(11):3089-96.
Willert K, Brink M, Wodarz A, Varmus H, Nusse R. PMID: 9214626; PMCID: PMC1169927.
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PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
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Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila. Cold Spring Harb Symp Quant Biol. 1997; 62:185-90.
Nusse R, Samos CH, Brink M, Willert K, Cadigan KM, Wodarz A, Fish M, Rulifson E. PMID: 9598351.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells. Neuron. 1993 Nov; 11(5):865-75.
Shackleford GM, Willert K, Wang J, Varmus HE. PMID: 8240810.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Efficient incorporation of human CD4 protein into avian leukosis virus particles. Science. 1990 Dec 07; 250(4986):1421-3.
Young JA, Bates P, Willert K, Varmus HE. PMID: 2175047.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells