Yun Sok Lee

Title(s)	Associate Professor In Residence, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
ORCID	0000-0001-7967-4734
vCard	Download vCard

Biography

Education and Training

Seoul National University
University of California San Diego

Overview

Interests

Obesity, Diabetes, Insulin Resistance, Immunometabolism, Inflammation, Hypoxia, Adipose Tissue

Websites

Lee Lab Web Homepage

ORNG Applications

Featured Publications

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

HIF-2a drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis. Sci Transl Med. 2024 Sep 11; 16(764):eadi0284. Jeelani I, Moon JS, da Cunha FF, Nasamran CA, Jeon S, Zhang X, Bandyopadhyay GK, Dobaczewska K, Mikulski Z, Hosseini M, Liu X, Kisseleva T, Brenner DA, Singh S, Loomba R, Kim M, Lee YS. PMID: 39259813.

View in: PubMed Mentions:
Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 May; 6(5):880-898. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38605183.

View in: PubMed Mentions: 3 Fields:
Met Metabolism
Translation:Humans Animals Cells
Eating macrophages for a healthy anti-NASH meal. Immunity. 2023 01 10; 56(1):3-5. Lee YS, Olefsky J. PMID: 36630915; PMCID: PMC10441811.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
The Mechanism for Adipose Endotrophin Production. Diabetes. 2022 08 01; 71(8):1617-1619. Lee YS. PMID: 35881834; PMCID: PMC9490353.

View in: PubMed Mentions: Fields:
End Endocrinology
HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity. Diabetes. 2022 07 01; 71(7):1508-1524. Moon JS, Riopel M, Seo JB, Herrero-Aguayo V, Isaac R, Lee YS. PMID: 35472707; PMCID: PMC9233300.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Animals
HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes. JCI Insight. 2021 11 08; 6(21). Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A. PMID: 34747371; PMCID: PMC8663561.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
ANT2 drives proinflammatory macrophage activation in obesity. JCI Insight. 2021 10 22; 6(20). Moon JS, da Cunha FF, Huh JY, Andreyev AY, Lee J, Mahata SK, Reis FC, Nasamran CA, Lee YS. PMID: 34676827; PMCID: PMC8564915.

View in: PubMed Mentions: 4 Fields:
Med Medicine (General)
Translation:Humans Animals
Chronic tissue inflammation and metabolic disease. Genes Dev. 2021 03 01; 35(5-6):307-328. Lee YS, Olefsky J. PMID: 33649162; PMCID: PMC7919414.

View in: PubMed Mentions: 87 Fields:
Mol Molecular Biology
Translation:Humans Cells
Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism. Mol Metab. 2020 11; 41:101039. Riopel M, Moon JS, Bandyopadhyay GK, You S, Lam K, Liu X, Kisseleva T, Brenner D, Lee YS. PMID: 32534258; PMCID: PMC7393408.

View in: PubMed Mentions: 10 Fields:
Met Metabolism
Translation:Humans Animals Cells
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat Rev Endocrinol. 2020 02; 16(2):81-90. Ying W, Fu W, Lee YS, Olefsky JM. PMID: 31836875; PMCID: PMC8315273.

View in: PubMed Mentions: 121 Fields:
End Endocrinology
Translation:Humans Animals Cells
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metab. 2020 01 07; 31(1):162-173.e5. El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. PMID: 31708444; PMCID: PMC7784082.

View in: PubMed Mentions: 41 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Animals Cells
Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Sci Rep. 2019 10 14; 9(1):14779. Lackey DE, Reis FCG, Isaac R, Zapata RC, El Ouarrat D, Lee YS, Bandyopadhyay G, Ofrecio JM, Oh DY, Osborn O. PMID: 31611602; PMCID: PMC6791934.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Animals Cells
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019 07; 5(7):eaaw4176. Lee YS, Riopel M, Cabrales P, Bandyopadhyay GK. PMID: 31281892; PMCID: PMC6609217.

View in: PubMed Mentions: 15 Fields:
Sci Science
Translation:Animals Cells
Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 07; 68(7):1415-1426. Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. PMID: 31010956; PMCID: PMC6609982.

View in: PubMed Mentions: 19 Fields:
End Endocrinology
Translation:Animals Cells
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478; PMCID: PMC6701710.

View in: PubMed Mentions: 109 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Mol Metab. 2019 02; 20:89-101. Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS. PMID: 30553772; PMCID: PMC6358552.

View in: PubMed Mentions: 17 Fields:
Met Metabolism
Translation:Animals Cells
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019 01; 1(1):86-97. Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM. PMID: 31528845; PMCID: PMC6746433.

View in: PubMed Mentions: 48 Fields:
Met Metabolism
Translation:Humans Animals Cells
Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest. 2018 04 02; 128(4):1458-1470. Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky JM, Lee YS. PMID: 29504946; PMCID: PMC5873865.

View in: PubMed Mentions: 18 Fields:
Med Medicine (General)
Translation:Animals Cells
An Integrated View of Immunometabolism. Cell. 2018 01 11; 172(1-2):22-40. Lee YS, Wollam J, Olefsky JM. PMID: 29328913; PMCID: PMC8451723.

View in: PubMed Mentions: 195 Fields:
Cel Cell Biology
Translation:Humans Animals
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 01; 127(3):1019-1030. Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. PMID: 28192375; PMCID: PMC5330737.

View in: PubMed Mentions: 65 Fields:
Med Medicine (General)
Translation:Animals Cells
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Cell Metab. 2015 Jul 07; 22(1):125-37. Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson C. PMID: 26052006; PMCID: PMC4584026.

View in: PubMed Mentions: 90 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals
GPR43 Potentiates β-Cell Function in Obesity. Diabetes. 2015 Sep; 64(9):3203-17. McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM. PMID: 26023106; PMCID: PMC4542437.

View in: PubMed Mentions: 95 Fields:
End Endocrinology
Translation:Humans Animals Cells
Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol Cell Biol. 2015 May; 35(10):1686-99. Kim JI, Huh JY, Sohn JH, Choe SS, Lee YS, Lim CY, Jo A, Park SB, Han W, Kim JB. PMID: 25733684; PMCID: PMC4405637.

View in: PubMed Mentions: 109 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. PMID: 25220417; PMCID: PMC4362785.

View in: PubMed Mentions: 29 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Animals Cells
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-1352. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. PMID: 24906151; PMCID: PMC4114226.

View in: PubMed Mentions: 277 Fields:
Cel Cell Biology
Translation:Animals Cells
Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring). 2014 Mar; 22(3):747-57. Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky JM, Sams A, Klip A. PMID: 24030890.

View in: PubMed Mentions: 86 Fields:
Met Metabolism Nut Nutritional Sciences Phy Physiology
Translation:Humans Animals Cells
Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. PMID: 24030101; PMCID: PMC3861721.

View in: PubMed Mentions: 31 Fields:
Bio Biochemistry Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
The fractalkine/CX3CR1 system regulates β cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. PMID: 23582329; PMCID: PMC3717389.

View in: PubMed Mentions: 70 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol Cell Biol. 2013 Jan; 33(2):328-39. Huh JY, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, Lee DS, Park SH, Seong RH, Choi CS, Kim JB. PMID: 23149942; PMCID: PMC3554106.

View in: PubMed Mentions: 71 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Loss of fibroblast HIF-1α accelerates tumorigenesis. Cancer Res. 2012 Jul 01; 72(13):3187-95. Kim JW, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, Johnson RS. PMID: 22556263; PMCID: PMC4089958.

View in: PubMed Mentions: 43 Fields:
Neo Neoplasms
Translation:Animals Cells
Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans. Mol Cells. 2012 Jan; 33(1):35-41. Alfadda AA, Fatma S, Chishti MA, Al-Naami MY, Elawad R, Mendoza CD, Jo H, Lee YS. PMID: 22134720; PMCID: PMC3887744.

View in: PubMed Mentions: 16 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals
Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes. 2011 Oct; 60(10):2474-83. Lee YS, Li P, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB. PMID: 21911747; PMCID: PMC3178297.

View in: PubMed Mentions: 277 Fields:
End Endocrinology
Translation:Animals
Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation. Mol Endocrinol. 2010 Jul; 24(7):1441-52. Kim AY, Lee YS, Kim KH, Lee JH, Lee HK, Jang SH, Kim SE, Lee GY, Lee JW, Jung SA, Chung HY, Jeong S, Kim JB. PMID: 20444885; PMCID: PMC5417469.

View in: PubMed Mentions: 106 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation. J Biol Chem. 2010 Jul 16; 285(29):22174-85. Lee YS, Choi JW, Hwang I, Lee JW, Lee JH, Kim AY, Huh JY, Koh YJ, Koh GY, Son HJ, Masuzaki H, Hotta K, Alfadda AA, Kim JB. PMID: 20442402; PMCID: PMC2903347.

View in: PubMed Mentions: 55 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochem Biophys Res Commun. 2010 Feb 12; 392(3):323-8. Kim SY, Kim AY, Lee HW, Son YH, Lee GY, Lee JW, Lee YS, Kim JB. PMID: 20060380.

View in: PubMed Mentions: 207 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity. Metabolism. 2010 Sep; 59(9):1241-51. Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K. PMID: 20045538; PMCID: PMC2891233.

View in: PubMed Mentions: 16 Fields:
Met Metabolism
Translation:Humans Animals Cells
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. Am J Physiol Endocrinol Metab. 2009 Apr; 296(4):E812-9. Kim WS, Lee YS, Cha SH, Jeong HW, Choe SS, Lee MR, Oh GT, Park HS, Lee KU, Lane MD, Kim JB. PMID: 19176354.

View in: PubMed Mentions: 97 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. Mol Cell Biol. 2009 Jan; 29(1):20-30. Chung SS, Kim M, Youn BS, Lee NS, Park JW, Lee IK, Lee YS, Kim JB, Cho YM, Lee HK, Park KS. PMID: 18936159; PMCID: PMC2612482.

View in: PubMed Mentions: 81 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. Mol Endocrinol. 2008 Sep; 22(9):2176-89. Lee YS, Kim AY, Choi JW, Kim M, Yasue S, Son HJ, Masuzaki H, Park KS, Kim JB. PMID: 18562625; PMCID: PMC5419460.

View in: PubMed Mentions: 86 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol Cell Biol. 2007 Jan; 27(2):438-52. Lee YS, Sohn DH, Han D, Lee HW, Seong RH, Kim JB. PMID: 17074803; PMCID: PMC1800793.

View in: PubMed Mentions: 21 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. J Mol Biol. 2006 Sep 08; 362(1):66-77. Kim MK, Lee JH, Kim H, Park SJ, Kim SH, Kang GB, Lee YS, Kim JB, Kim KK, Suh SW, Eom SH. PMID: 16901503.

View in: PubMed Mentions: 42 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006 Aug; 55(8):2256-64. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB. PMID: 16873688.

View in: PubMed Mentions: 381 Fields:
End Endocrinology
Translation:Animals Cells
Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation. Mol Endocrinol. 2006 Oct; 20(10):2432-43. Lee HW, Suh JH, Kim AY, Lee YS, Park SY, Kim JB. PMID: 16728531.

View in: PubMed Mentions: 102 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol Cell Biol. 2005 Jun; 25(12):5146-57. Park J, Rho HK, Kim KH, Choe SS, Lee YS, Kim JB. PMID: 15923630; PMCID: PMC1140588.

View in: PubMed Mentions: 73 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Regulation of adipocyte differentiation and insulin action with rapamycin. Biochem Biophys Res Commun. 2004 Sep 03; 321(4):942-8. Cho HJ, Park J, Lee HW, Lee YS, Kim JB. PMID: 15358118.

View in: PubMed Mentions: 53 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol. 2004 Apr; 24(8):3430-44. Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MG, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, Kim JB. PMID: 15060163; PMCID: PMC381668.

View in: PubMed Mentions: 101 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element-binding protein 1c regulates mouse adiponectin expression. J Biol Chem. 2004 May 21; 279(21):22108-17. Seo JB, Moon HM, Noh MJ, Lee YS, Jeong HW, Yoo EJ, Kim WS, Park J, Youn BS, Kim JW, Park SD, Kim JB. PMID: 15037635.

View in: PubMed Mentions: 37 Fields:
Bio Biochemistry
Translation:Animals Cells
Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res. 2003 Dec 15; 31(24):7165-74. Lee YS, Lee HH, Park J, Yoo EJ, Glackin CA, Choi YI, Jeon SH, Seong RH, Park SD, Kim JB. PMID: 14654692; PMCID: PMC291873.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry
Translation:Animals Cells