Volker Vallon

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9211-2063 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    2025Carl W. Gottschalk Distinguished Lectureship Award, American Physiological Society
    2024Hopfer Lecture, Case Western Reserve University
    2024Steven Hebert Lecturer Award, American Physiological Society
    2023Keynote Lecture, EASD Workshops, Oxford
    2023Keynote Lecture, Membrane Transport, St Andrews
    2022Plenary Lecture, Europhysiology, Copenhagen
    2021Fellow American Physiological Society
    2021Fellow American Society of Nephrology
    2020Plenary Lecture, German Society of Nephrology, Berlin
    2019Visiting Professorship, University of Utah, Salt Lake City
    2007Young Investigator Award for Excellence in Renal Physiology, American Physiological Society
    2006Keynote Lecture, International Society of Hypertension, Tokio
    2006Keynote Lecture. Annual Meeting West Coast Salt and Water Club, Morro Bay
    2004New Investigator Award in Regulatory and Integrative Physiology, American Physiological Society

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of acute kidney injury due to mechanical ventilation
    NIH/NIDDK R01DK136756May 15, 2024 - Apr 30, 2029
    Role: Co-Investigator
    UAB-UCSD O’Brien Center for Acute Kidney Injury Research
    NIH/NIDDK U54 DK137307Sep 1, 2023 - Jun 30, 2028
    Role: Co-Investigator, Director of Kidney Physiology Core
    Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases
    NIH/NIDDK R01DK133930Aug 1, 2023 - May 31, 2028
    Role: Co-Investigator
    Glomerular and tubular function in the diabetic kidney
    NIH/NIDDK R01DK112042Apr 17, 2023 - Mar 30, 2027
    Role: Principal Investigator
    Significance of tubuloglomerular feedback in SGLT1 and SGLT2 inhibition in diabetic kidney disease
    NIH/NIDDK R01DK134616Apr 1, 2023 - Mar 31, 2028
    Role: Co-Investigator (PI VMRF subcontract) (with Boston University)
    Glomerular and tubular function in the recovering kidney
    NIH/NIDDK R01DK132690Jan 1, 2023 - Nov 30, 2027
    Role: Principal Investigator
    Role of Claudin-2 in Calcium Homeostasis and Kidney Stone Disease
    NIH/NIDDK R01DK115727Sep 18, 2019 - Aug 31, 2024
    Role: Co-Investigator (PI UCSD subcontract) (with University of Kansas)
    The Contribution of Kidney Disease to Age-Associated Cognitive Decline
    NIH/NIA RF1AG061296Jul 15, 2019 - Mar 31, 2024
    Role: Co-Investigator (PI UCSD subcontract) (with Salk Institute)
    Role of Tubuloglomerular Feedback in Development of Hypertension in Diabetes
    NIH/NHLBI R01HL142814Apr 1, 2019 - Mar 31, 2023
    Role: Co-Investigator (PI UCSD subcontract) (with University of South Florida)
    UAB-UCSD O’Brien Core Center for Acute Kidney Injury Research
    NIH/NIDDK P30DK079337Aug 1, 2018 - Jul 31, 2023
    Role: Co-Investigator (Director, Renal Physiology) (with University of Alabama Birmingham)
    Glomerular and Tubular Function in the Diabetic Kidney
    NIH/NIDDK R01DK112042May 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Unraveling Kidney Physiology, Pathophysiology & Therapeutics: A Modeling Approach
    NIH/NIDDK R01DK106102May 1, 2016 - Apr 30, 2020
    Role: Co-Investigator (PI UCSD subcontract) (with Duke University)

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. State-of-the-art-review Mechanisms of action of SGLT2 inhibitors and clinical implications. Am J Hypertens. 2024 Jul 17. Vallon V. PMID: 39017631.
      View in: PubMed   Mentions:    Fields:    
    2. Glycolytic lactate in diabetic kidney disease. JCI Insight. 2024 Jun 10; 9(11). Darshi M, Kugathasan L, Maity S, Sridhar VS, Fernandez R, Limonte CP, Grajeda BI, Saliba A, Zhang G, Drel VR, Kim JJ, Montellano R, Tumova J, Montemayor D, Wang Z, Liu JJ, Wang J, Perkins BA, Lytvyn Y, Natarajan L, Lim SC, Feldman H, Toto R, Sedor JR, Patel J, Waikar SS, Brown J, Osman Y, He J, Chen J, Reeves WB, de Boer IH, Roy S, Vallon V, Hallan S, Gelfond JA, Cherney DZ, Sharma K, Kidney Precision Medicine Project, and the CRIC Study Investigators. PMID: 38855868.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system? Nephrol Dial Transplant. 2024 Mar 04. Vallon V. PMID: 38439675.
      View in: PubMed   Mentions: 2     Fields:    
    4. Deletion, but not heterozygosity, of eNOS raises blood pressure and aggravates nephropathy in BTBR ob/ob mice. Nephron. 2024 Feb 01. Kanoo S, Goodluck H, Kim YC, Garrido AN, Crespo-Masip M, Lopez N, Zhang H, Gonzalez-Villalobos RA, Ma LJ, Vallon V. PMID: 38301618; PMCID: PMC11291698.
      View in: PubMed   Mentions:    Fields:    
    5. Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs mouse sperm movement. Mol Reprod Dev. 2024 Jan; 91(1):e23723. Numata S, Oishee MJ, McDermott J, Koepsell H, Vallon V, Blanco G. PMID: 38282316.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Metabolic Communication by SGLT2 Inhibition. Circulation. 2024 03 12; 149(11):860-884. Billing AM, Kim YC, Gullaksen S, Schrage B, Raabe J, Hutzfeldt A, Demir F, Kovalenko E, Lassé M, Dugourd A, Fallegger R, Klampe B, Jaegers J, Li Q, Kravtsova O, Crespo-Masip M, Palermo A, Fenton RA, Hoxha E, Blankenberg S, Kirchhof P, Huber TB, Laugesen E, Zeller T, Chrysopoulou M, Saez-Rodriguez J, Magnussen C, Eschenhagen T, Staruschenko A, Siuzdak G, Poulsen PL, Schwab C, Cuello F, Vallon V, Rinschen MM. PMID: 38152989; PMCID: PMC10922673.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy. Am J Physiol Renal Physiol. 2024 02 01; 326(2):F227-F240. Oe Y, Kim YC, Sidorenko VS, Zhang H, Kanoo S, Lopez N, Goodluck HA, Crespo-Masip M, Vallon V. PMID: 38031729; PMCID: PMC11198975.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. CRRT 2023 Meeting: Targeting Amino Acid Transport to Improve Acute Kidney Injury Outcome. Nephron. 2023; 147(12):774-777. Oe Y, Vallon V. PMID: 37490876; PMCID: PMC10808280.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    9. Did you know how SGLT2 inhibitors protect the kidney? Acta Physiol (Oxf). 2023 08; 238(4):e14011. Layton AT, Vallon V. PMID: 37288493.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function. Am J Physiol Renal Physiol. 2023 06 01; 324(6):F544-F557. Kim YC, Fattah H, Fu Y, Nespoux J, Vallon V. PMID: 37102688; PMCID: PMC10228677.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Responses in Blood Pressure and Kidney Function to Soluble Guanylyl Cyclase Stimulation or Activation in Normal and Diabetic Rats. Nephron. 2023; 147(5):281-300. Patel R, Fu Y, Khang S, Benardeau AM, Thomson SC, Vallon V. PMID: 36265461; PMCID: PMC10115913.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Renoprotective Effects of SGLT2 Inhibitors. Heart Fail Clin. 2022 Oct; 18(4):539-549. Vallon V. PMID: 36216484; PMCID: PMC9558099.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19). Am J Physiol Renal Physiol. 2022 10 01; 323(4):F455-F467. Navarro Garrido A, Kim YC, Oe Y, Zhang H, Crespo-Masip M, Goodluck HA, Kanoo S, Sanders PW, Bröer S, Vallon V. PMID: 35979966; PMCID: PMC9484999.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    14. Corrigendum to Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. "Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration." Kidney Int. 2022;101:541-550. Kidney Int. 2022 Aug; 102(2):448. Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. PMID: 35870819; PMCID: PMC9397148.
      View in: PubMed   Mentions:    Fields:    
    15. SGLT2 inhibitor and loop diuretic induce different vasopressin and fluid homeostatic responses in nondiabetic rats. Am J Physiol Renal Physiol. 2022 09 01; 323(3):F361-F369. Masuda T, Ohara K, Vallon V, Nagata D. PMID: 35900341; PMCID: PMC9423725.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    16. The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1. Kidney Dial. 2022 Jun; 2(2):349-368. Oe Y, Vallon V. PMID: 36380914; PMCID: PMC9648862.
      View in: PubMed   Mentions: 3  
    17. Protecting the Kidney: The Unexpected Logic of Inhibiting a Glucose Transporter. Clin Pharmacol Ther. 2022 09; 112(3):434-438. Vallon V, Kim YC. PMID: 35689828.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans. J Bone Miner Res. 2022 06; 37(6):1170-1178. Sharma S, Katz R, Ginsberg C, Bullen A, Vallon V, Thomson S, Moe OW, Hoofnagle AN, de Leeuw PW, Kroon AA, Houben AJHM, Ix JH. PMID: 35373859; PMCID: PMC9177785.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    19. SGLT2 Inhibition and Uric Acid Excretion in Patients with Type 2 Diabetes and Normal Kidney Function. Clin J Am Soc Nephrol. 2022 05; 17(5):663-671. Suijk DLS, van Baar MJB, van Bommel EJM, Iqbal Z, Krebber MM, Vallon V, Touw D, Hoorn EJ, Nieuwdorp M, Kramer MMH, Joles JA, Bjornstad P, van Raalte DH. PMID: 35322793; PMCID: PMC9269569.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    20. Renal Tubular Handling of Glucose and Fructose in Health and Disease. Compr Physiol. 2021 12 29; 12(1):2995-3044. Vallon V, Nakagawa T. PMID: 34964123; PMCID: PMC9832976.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration. Kidney Int. 2022 03; 101(3):541-550. Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. PMID: 34843754; PMCID: PMC8863629.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    22. Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice. Hypertension. 2021 12; 78(6):1760-1770. Zhang J, Wang X, Cui Y, Jiang S, Wei J, Chan J, Thalakola A, Le T, Xu L, Zhao L, Wang L, Jiang K, Cheng F, Patel T, Buggs J, Vallon V, Liu R. PMID: 34657443; PMCID: PMC8651058.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    23. UAB-UCSD O'Brien Center for Acute Kidney Injury Research. Am J Physiol Renal Physiol. 2021 05 01; 320(5):F870-F882. Curtis LM, George J, Vallon V, Barnes S, Darley-Usmar V, Vaingankar S, Cutter GR, Gutierrez OM, Seifert M, Ix JH, Mehta RL, Sanders PW, Agarwal A. PMID: 33779316; PMCID: PMC8424552.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats. Am J Physiol Renal Physiol. 2021 05 01; 320(5):F761-F771. Thomson SC, Vallon V. PMID: 33645318; PMCID: PMC8174804.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    25. Effects of SGLT2 Inhibitors on Kidney and Cardiovascular Function. Annu Rev Physiol. 2021 02 10; 83:503-528. Vallon V, Verma S. PMID: 33197224; PMCID: PMC8017904.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    26. SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2021 01; 77(1):94-109. Tuttle KR, Brosius FC, Cavender MA, Fioretto P, Fowler KJ, Heerspink HJL, Manley T, McGuire DK, Molitch ME, Mottl AK, Perreault L, Rosas SE, Rossing P, Sola L, Vallon V, Wanner C, Perkovic V. PMID: 33121838.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    27. SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Diabetes. 2021 01; 70(1):1-16. Tuttle KR, Brosius FC, Cavender MA, Fioretto P, Fowler KJ, Heerspink HJL, Manley T, McGuire DK, Molitch ME, Mottl AK, Perreault L, Rosas SE, Rossing P, Sola L, Vallon V, Wanner C, Perkovic V. PMID: 33106255; PMCID: PMC8162454.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    28. A role for tubular Na+/H+ exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol. 2020 10 01; 319(4):F712-F728. Onishi A, Fu Y, Patel R, Darshi M, Crespo-Masip M, Huang W, Song P, Freeman B, Kim YC, Soleimani M, Sharma K, Thomson SC, Vallon V. PMID: 32893663; PMCID: PMC7642886.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    29. A special issue on glucose transporters in health and disease. Pflugers Arch. 2020 09; 472(9):1107-1109. Koepsell H, Vallon V. PMID: 32780191; PMCID: PMC7484381.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome. Nephron. 2020; 144(8):400-412. Kim YC, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, Dhar D, Vallon V. PMID: 32629454; PMCID: PMC8011852.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors? Kidney Int. 2020 09; 98(3):579-589. Hesp AC, Schaub JA, Prasad PV, Vallon V, Laverman GD, Bjornstad P, van Raalte DH. PMID: 32739206; PMCID: PMC8397597.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    32. The tubular hypothesis of nephron filtration and diabetic kidney disease. Nat Rev Nephrol. 2020 06; 16(6):317-336. Vallon V, Thomson SC. PMID: 32152499; PMCID: PMC7242158.
      View in: PubMed   Mentions: 139     Fields:    Translation:Humans
    33. Glucose transporters in the kidney in health and disease. Pflugers Arch. 2020 09; 472(9):1345-1370. Vallon V. PMID: 32144488; PMCID: PMC7483786.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    34. Gene knockout of the Na+-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion. Am J Physiol Renal Physiol. 2020 05 01; 318(5):F1100-F1112. Nespoux J, Patel R, Zhang H, Huang W, Freeman B, Sanders PW, Kim YC, Vallon V. PMID: 32116018; PMCID: PMC7294332.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    35. Renal effects of SGLT2 inhibitors: an update. Curr Opin Nephrol Hypertens. 2020 Mar; 29(2):190-198. Nespoux J, Vallon V. PMID: 31815757; PMCID: PMC7224333.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    36. Osmotic diuresis by SGLT2 inhibition stimulates vasopressin-induced water reabsorption to maintain body fluid volume. Physiol Rep. 2020 01; 8(2):e14360. Masuda T, Muto S, Fukuda K, Watanabe M, Ohara K, Koepsell H, Vallon V, Nagata D. PMID: 31994353; PMCID: PMC6987478.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    37. Renal Effects of Sodium-Glucose Co-Transporter Inhibitors. Am J Cardiol. 2019 12 15; 124 Suppl 1:S28-S35. Thomson SC, Vallon V. PMID: 31741437; PMCID: PMC7258222.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    38. Extracellular Nucleotides and P2 Receptors in Renal Function. Physiol Rev. 2020 01 01; 100(1):211-269. Vallon V, Unwin R, Inscho EW, Leipziger J, Kishore BK. PMID: 31437091; PMCID: PMC6985785.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    39. Effect of renal tubule-specific knockdown of the Na+/H+ exchanger NHE3 in Akita diabetic mice. Am J Physiol Renal Physiol. 2019 08 01; 317(2):F419-F434. Onishi A, Fu Y, Darshi M, Crespo-Masip M, Huang W, Song P, Patel R, Kim YC, Nespoux J, Freeman B, Soleimani M, Thomson S, Sharma K, Vallon V. PMID: 31166707; PMCID: PMC6732454.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    40. Knockout of Na+-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration. Am J Physiol Renal Physiol. 2019 07 01; 317(1):F207-F217. Song P, Huang W, Onishi A, Patel R, Kim YC, van Ginkel C, Fu Y, Freeman B, Koepsell H, Thomson S, Liu R, Vallon V. PMID: 31091127; PMCID: PMC6692722.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    41. How Do Kidneys Adapt to a Deficit or Loss in Nephron Number? Physiology (Bethesda). 2019 05 01; 34(3):189-197. Fattah H, Layton A, Vallon V. PMID: 30968755; PMCID: PMC6734068.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    42. Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion. Am J Physiol Renal Physiol. 2019 06 01; 316(6):F1201-F1210. Nespoux J, Patel R, Hudkins KL, Huang W, Freeman B, Kim YC, Koepsell H, Alpers CE, Vallon V. PMID: 30995111; PMCID: PMC6620597.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    43. Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia. J Am Soc Nephrol. 2019 04; 30(4):578-593. Zhang J, Wei J, Jiang S, Xu L, Wang L, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. PMID: 30867247; PMCID: PMC6442354.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    44. SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1. Am J Physiol Renal Physiol. 2019 01 01; 316(1):F173-F185. Novikov A, Fu Y, Huang W, Freeman B, Patel R, van Ginkel C, Koepsell H, Busslinger M, Onishi A, Nespoux J, Vallon V. PMID: 30427222; PMCID: PMC6383194.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    45. Renal tubular solute transport and oxygen consumption: insights from computational models. Curr Opin Nephrol Hypertens. 2018 09; 27(5):384-389. Layton AT, Vallon V. PMID: 30016311.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    46. Development of SGLT1 and SGLT2 inhibitors. Diabetologia. 2018 10; 61(10):2079-2086. Rieg T, Vallon V. PMID: 30132033; PMCID: PMC6124499.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimals
    47. SGLT2 inhibition and kidney protection. Clin Sci (Lond). 2018 06 29; 132(12):1329-1339. Nespoux J, Vallon V. PMID: 29954951; PMCID: PMC6648703.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    48. Tubular Recovery after Acute Kidney Injury. Nephron. 2018; 140(2):140-143. Fattah H, Vallon V. PMID: 29852498; PMCID: PMC6432909.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    49. Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F653-F664. Masuda T, Watanabe Y, Fukuda K, Watanabe M, Onishi A, Ohara K, Imai T, Koepsell H, Muto S, Vallon V, Nagata D. PMID: 29790389; PMCID: PMC6734084.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    50. The Potential Role of SGLT2 Inhibitors in the Treatment of Type 1 Diabetes Mellitus. Drugs. 2018 May; 78(7):717-726. Fattah H, Vallon V. PMID: 29663292; PMCID: PMC6429906.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    51. Renal Effects of Incretin-Based Diabetes Therapies: Pre-clinical Predictions and Clinical Trial Outcomes. Curr Diab Rep. 2018 04 13; 18(5):28. Thomson SC, Vallon V. PMID: 29654381; PMCID: PMC6426321.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    52. Cardiovascular benefits of SGLT2 inhibition in diabetes and chronic kidney diseases. Acta Physiol (Oxf). 2018 04; 222(4):e13050. Layton AT, Vallon V. PMID: 29424089; PMCID: PMC5867254.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    53. Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol. 2018 08 01; 315(2):F386-F394. Fu Y, Breljak D, Onishi A, Batz F, Patel R, Huang W, Song P, Freeman B, Mayoux E, Koepsell H, Anzai N, Nigam SK, Sabolic I, Vallon V. PMID: 29412698; PMCID: PMC6139528.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    54. SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism. Am J Physiol Renal Physiol. 2018 05 01; 314(5):F969-F984. Layton AT, Vallon V. PMID: 29361669; PMCID: PMC6031905.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    55. Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis. Am J Physiol Renal Physiol. 2018 04 01; 314(4):F643-F657. Layton AT, Edwards A, Vallon V. PMID: 29357444; PMCID: PMC5966763.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    56. Diabetes mellitus: Cardiovascular and renal benefits of SGLT2 inhibition: insights from CANVAS. Nat Rev Nephrol. 2017 09; 13(9):517-518. Vallon V, Thomson SC. PMID: 28781373.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    57. Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F199-F209. Layton AT, Edwards A, Vallon V. PMID: 28331059; PMCID: PMC5582891.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    58. Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives. Diabetes Metab Res Rev. 2017 07; 33(5). Qiu H, Novikov A, Vallon V. PMID: 28099783.
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    59. Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis. Am J Physiol Renal Physiol. 2017 05 01; 312(5):F819-F835. Hallow KM, Gebremichael Y, Helmlinger G, Vallon V. PMID: 28148531; PMCID: PMC5451553.
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    60. Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia. 2017 02; 60(2):215-225. Vallon V, Thomson SC. PMID: 27878313; PMCID: PMC5884445.
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    61. A computational model for simulating solute transport and oxygen consumption along the nephrons. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1378-F1390. Layton AT, Vallon V, Edwards A. PMID: 27707705; PMCID: PMC5210192.
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    62. Solute transport and oxygen consumption along the nephrons: effects of Na+ transport inhibitors. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1217-F1229. Layton AT, Laghmani K, Vallon V, Edwards A. PMID: 27707706; PMCID: PMC5210208.
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    63. SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone. Am J Physiol Renal Physiol. 2017 01 01; 312(1):F65-F76. Yang L, Frindt G, Lang F, Kuhl D, Vallon V, Palmer LG. PMID: 27413200; PMCID: PMC5283884.
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    64. Erratum: Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. Sci Rep. 2016 07 07; 6:28124. Gallo LA, Ward MS, Fotheringham AK, Zhuang A, Borg DJ, Flemming NB, Harvie BM, Kinneally TL, Yeh SM, McCarthy DA, Koepsell H, Vallon V, Pollock C, Panchapakesan U, Forbes JM. PMID: 27389496; PMCID: PMC4936511.
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    65. Tubular Transport in Acute Kidney Injury: Relevance for Diagnosis, Prognosis and Intervention. Nephron. 2016; 134(3):160-166. Vallon V. PMID: 27238156; PMCID: PMC5089910.
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    66. Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. Sci Rep. 2016 05 26; 6:26428. Gallo LA, Ward MS, Fotheringham AK, Zhuang A, Borg DJ, Flemming NB, Harvie BM, Kinneally TL, Yeh SM, McCarthy DA, Koepsell H, Vallon V, Pollock C, Panchapakesan U, Forbes JM. PMID: 27226136; PMCID: PMC4881020.
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    67. Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus. Expert Opin Ther Targets. 2016 Sep; 20(9):1109-25. Song P, Onishi A, Koepsell H, Vallon V. PMID: 26998950; PMCID: PMC5045806.
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    68. Predicted consequences of diabetes and SGLT inhibition on transport and oxygen consumption along a rat nephron. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1269-83. Layton AT, Vallon V, Edwards A. PMID: 26764207; PMCID: PMC4935777.
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    69. Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update. Curr Opin Nephrol Hypertens. 2016 Jan; 25(1):50-8. Novikov A, Vallon V. PMID: 26575393; PMCID: PMC4703043.
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    70. A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans. Naunyn Schmiedebergs Arch Pharmacol. 2015 Aug; 388(8):801-16. Michel MC, Mayoux E, Vallon V. PMID: 26108304; PMCID: PMC5896322.
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    71. Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1343-57. Layton AT, Vallon V, Edwards A. PMID: 25855513; PMCID: PMC4469883.
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    72. Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab Vasc Dis Res. 2015 Mar; 12(2):78-89. Gallo LA, Wright EM, Vallon V. PMID: 25616707; PMCID: PMC5886707.
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    73. PPARγ agonist-induced fluid retention depends on αENaC expression in connecting tubules. Nephron. 2015; 129(1):68-74. Fu Y, Gerasimova M, Batz F, Kuczkowski A, Alam Y, Sanders PW, Ronzaud C, Hummler E, Vallon V. PMID: 25531136; PMCID: PMC4323851.
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    74. Mineralocorticoid-induced sodium appetite and renal salt retention: evidence for common signaling and effector mechanisms. Nephron Physiol. 2014; 128(1-2):8-16. Fu Y, Vallon V. PMID: 25376899; PMCID: PMC4275376.
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    75. Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion. J Biol Chem. 2014 Dec 12; 289(50):34642-53. Xie R, Dong X, Wong C, Vallon V, Tang B, Sun J, Yang S, Dong H. PMID: 25331955; PMCID: PMC4263870.
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    76. The mechanisms and therapeutic potential of SGLT2 inhibitors in diabetes mellitus. Annu Rev Med. 2015; 66:255-70. Vallon V. PMID: 25341005.
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    77. Do tubular changes in the diabetic kidney affect the susceptibility to acute kidney injury? Nephron Clin Pract. 2014; 127(1-4):133-8. Vallon V. PMID: 25343837.
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    78. Intestinal regulation of urinary sodium excretion and the pathophysiology of diabetic kidney disease: a focus on glucagon-like peptide 1 and dipeptidyl peptidase 4. Exp Physiol. 2014 Sep; 99(9):1140-5. Vallon V, Docherty NG. PMID: 25085841; PMCID: PMC4162767.
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    79. Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis. J Am Soc Nephrol. 2014 Oct; 25(10):2159-68. Kumar R, Vallon V. PMID: 24876121; PMCID: PMC4178449.
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    80. Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study. Am J Physiol Renal Physiol. 2014 Jul 15; 307(2):F137-46. Edwards A, Castrop H, Laghmani K, Vallon V, Layton AT. PMID: 24848496; PMCID: PMC4101627.
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    81. Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney. J Am Soc Nephrol. 2014 Sep; 25(9):2067-78. Borsting E, Patel SV, Declèves AE, Lee SJ, Rahman QM, Akira S, Satriano J, Sharma K, Vallon V, Cunard R. PMID: 24676635; PMCID: PMC4147976.
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    82. P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells. Pflugers Arch. 2014 Nov; 466(11):2035-47. Gailly P, Szutkowska M, Olinger E, Debaix H, Seghers F, Janas S, Vallon V, Devuyst O. PMID: 24463702.
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    83. Dipeptidyl peptidase IV inhibitor lowers PPARγ agonist-induced body weight gain by affecting food intake, fat mass, and beige/brown fat but not fluid retention. Am J Physiol Endocrinol Metab. 2014 Feb 15; 306(4):E388-98. Masuda T, Fu Y, Eguchi A, Czogalla J, Rose MA, Kuczkowski A, Gerasimova M, Feldstein AE, Scadeng M, Vallon V. PMID: 24347054; PMCID: PMC3923087.
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    84. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol. 2014 Jan; 306(2):F194-204. Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T. PMID: 24226524; PMCID: PMC3920018.
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    85. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. Am J Physiol Renal Physiol. 2014 Jan; 306(2):F188-93. Rieg T, Masuda T, Gerasimova M, Mayoux E, Platt K, Powell DR, Thomson SC, Koepsell H, Vallon V. PMID: 24226519; PMCID: PMC3920019.
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    86. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013 Jan 15; 304(2):F156-67. Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. PMID: 23152292; PMCID: PMC3543626.
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    87. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol. 2013 Jan; 182(1):96-106. Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V. PMID: 23123217; PMCID: PMC3532715.
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    88. In vivo and ex vivo analysis of tubule function. Compr Physiol. 2012 Oct; 2(4):2495-525. Stockand JD, Vallon V, Ortiz P. PMID: 23720256.
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    89. P2Y receptors and kidney function. Wiley Interdiscip Rev Membr Transp Signal. 2012; 1(6):731-742. Vallon V, Stockand J, Rieg T. PMID: 23145369; PMCID: PMC3490424.
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    90. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am J Physiol Renal Physiol. 2012 Oct; 303(7):F963-71. Rieg T, Gerasimova M, Murray F, Masuda T, Tang T, Rose M, Drucker DJ, Vallon V. PMID: 22832924; PMCID: PMC3469689.
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    91. Acute saline expansion increases nephron filtration and distal flow rate but maintains tubuloglomerular feedback responsiveness: role of adenosine A(1) receptors. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F405-11. Blantz RC, Singh P, Deng A, Thomson SC, Vallon V. PMID: 22622464; PMCID: PMC3433865.
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    92. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1293-9. Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T. PMID: 22338083; PMCID: PMC3362066.
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    93. Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol. 2012 Apr 15; 302(8):C1174-88. Sabolic I, Vrhovac I, Eror DB, Gerasimova M, Rose M, Breljak D, Ljubojevic M, Brzica H, Sebastiani A, Thal SC, Sauvant C, Kipp H, Vallon V, Koepsell H. PMID: 22262063; PMCID: PMC3774553.
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    94. Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney. Annu Rev Physiol. 2012; 74:351-75. Vallon V, Thomson SC. PMID: 22335797; PMCID: PMC3807782.
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    95. Intrinsic control of sodium excretion in the distal nephron by inhibitory purinergic regulation of the epithelial Na(+) channel. Curr Opin Nephrol Hypertens. 2012 Jan; 21(1):52-60. Toney GM, Vallon V, Stockand JD. PMID: 22143248; PMCID: PMC3689579.
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    96. Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney. Am J Physiol Renal Physiol. 2012 Mar 01; 302(5):F540-51. Borsting E, Cheng VP, Glass CK, Vallon V, Cunard R. PMID: 22169011; PMCID: PMC3353644.
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    97. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012 Jan; 61(1):187-96. Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, Parker HE, Gribble FM, Reimann F, Lang F, Wiese S, Sabolic I, Sendtner M, Koepsell H. PMID: 22124465; PMCID: PMC3237647.
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    98. Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport. Clin Exp Nephrol. 2012 Feb; 16(1):73-80. Lang F, Vallon V. PMID: 22038256.
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    99. Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 01; 302(1):R75-83. Thomson SC, Rieg T, Miracle C, Mansoury H, Whaley J, Vallon V, Singh P. PMID: 21940401; PMCID: PMC3349378.
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    100. Pathophysiology of the diabetic kidney. Compr Physiol. 2011 Jul; 1(3):1175-232. Vallon V, Komers R. PMID: 23733640; PMCID: PMC6029262.
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    101. Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F463-75. Vallon V, Rieg T. PMID: 21715471; PMCID: PMC3174559.
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    102. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. PMID: 21616289; PMCID: PMC3236642.
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    103. Anomalous role for dietary salt in diabetes mellitus? Nat Rev Endocrinol. 2011 May 31; 7(7):377-8. Vallon V, Thomson SC. PMID: 21629234; PMCID: PMC3335262.
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    104. Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum. Gastroenterology. 2011 Sep; 141(3):854-63. Tuo B, Wen G, Wei J, Liu X, Wang X, Zhang Y, Wu H, Dong X, Chow JY, Vallon V, Dong H. PMID: 21699784; PMCID: PMC3163800.
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    105. P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R510-8. Rieg T, Gerasimova M, Boyer JL, Insel PA, Vallon V. PMID: 21613580; PMCID: PMC3154711.
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    106. Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol Pharmacol. 2011 Jul; 80(1):147-54. Sweeney DE, Vallon V, Rieg T, Wu W, Gallegos TF, Nigam SK. PMID: 21493727; PMCID: PMC3127534.
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    107. The proximal tubule in the pathophysiology of the diabetic kidney. Am J Physiol Regul Integr Comp Physiol. 2011 May; 300(5):R1009-22. Vallon V. PMID: 21228342; PMCID: PMC3094037.
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    108. Molecular determinants of renal glucose reabsorption. Focus on "Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2". Am J Physiol Cell Physiol. 2011 Jan; 300(1):C6-8. Vallon V. PMID: 21048164; PMCID: PMC3023181.
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    109. SGK, renal function and hypertension. J Nephrol. 2010 Nov-Dec; 23 Suppl 16:S124-9. Lang F, Huang DY, Vallon V. PMID: 21170869; PMCID: PMC4026186.
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    110. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec; 21(12):2059-68. Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. PMID: 20864687; PMCID: PMC3014019.
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    111. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol. 2010 Nov; 21(11):1903-11. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O. PMID: 20813869; PMCID: PMC3014005.
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    112. Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Curr Opin Nephrol Hypertens. 2010 Sep; 19(5):425-31. Vallon V, Sharma K. PMID: 20539226; PMCID: PMC5886710.
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    113. TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1. Am J Physiol Renal Physiol. 2010 Nov; 299(5):F965-72. Morse E, Schroth J, You YH, Pizzo DP, Okada S, Ramachandrarao S, Vallon V, Sharma K, Cunard R. PMID: 20660016; PMCID: PMC2980398.
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    114. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol. 2011 Jan; 22(1):104-12. Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. PMID: 20616166; PMCID: PMC3014039.
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    115. Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C374-80. Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC, Thomson SC. PMID: 20505038; PMCID: PMC2928628.
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    116. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. PMID: 20097874; PMCID: PMC2874475.
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    117. Targeting SGK1 in diabetes. Expert Opin Ther Targets. 2009 Nov; 13(11):1303-11. Lang F, Görlach A, Vallon V. PMID: 19764891; PMCID: PMC2798808.
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    118. The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens. 2009 Sep; 18(5):439-48. Lang F, Artunc F, Vallon V. PMID: 19584721; PMCID: PMC2883450.
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    119. Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F704-12. Vallon V, Schroth J, Lang F, Kuhl D, Uchida S. PMID: 19570885; PMCID: PMC2739704.
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    120. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera DR, Ross RS, Nigam SK. PMID: 19439520; PMCID: PMC2711709.
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    121. Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1. Am J Physiol Regul Integr Comp Physiol. 2009 Jun; 296(6):R1695-701. Boini KM, Graf D, Hennige AM, Koka S, Kempe DS, Wang K, Ackermann TF, Föller M, Vallon V, Pfeifer K, Schleicher E, Ullrich S, Häring HU, Häussinger D, Lang F. PMID: 19369585; PMCID: PMC2692790.
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    122. Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus. Nephron Physiol. 2009; 111(3):p30-8. Vallon V, Schroth J, Satriano J, Blantz RC, Thomson SC, Rieg T. PMID: 19276628; PMCID: PMC2904473.
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    123. Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity. J Am Soc Nephrol. 2009 Apr; 20(4):721-9. Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B, Cunard R, Stockand J. PMID: 19158355; PMCID: PMC2663822.
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    124. SGK1-sensitive renal tubular glucose reabsorption in diabetes. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F859-66. Ackermann TF, Boini KM, Völkl H, Bhandaru M, Bareiss PM, Just L, Vallon V, Amann K, Kuhl D, Feng Y, Hammes HP, Lang F. PMID: 19158347; PMCID: PMC3973646.
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    125. Adenosine receptors and the kidney. Handb Exp Pharmacol. 2009; (193):443-70. Vallon V, Osswald H. PMID: 19639291; PMCID: PMC6027627.
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    126. Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone. Kidney Int. 2008 Dec; 74(11):1373-5. Vallon V. PMID: 19008908; PMCID: PMC2944250.
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    127. ATP and adenosine in the local regulation of water transport and homeostasis by the kidney. Am J Physiol Regul Integr Comp Physiol. 2009 Feb; 296(2):R419-27. Rieg T, Vallon V. PMID: 19020292; PMCID: PMC2643977.
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    128. Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem. 2008 Dec 26; 283(52):36599-607. Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD. PMID: 18981175; PMCID: PMC2605978.
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    129. Micropuncturing the nephron. Pflugers Arch. 2009 May; 458(1):189-201. Vallon V. PMID: 18752000; PMCID: PMC2954491.
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    130. Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F995-F1002. Miracle CM, Rieg T, Mansoury H, Vallon V, Thomson SC. PMID: 18562630; PMCID: PMC2576161.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    131. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol. 2008 Sep; 19(9):1732-40. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. PMID: 18508962; PMCID: PMC2518443.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    132. Effect of adenosine on membrane potential and Ca2+ in juxtaglomerular cells. Comparison with angiotensin II. Kidney Blood Press Res. 2008; 31(2):94-103. Laske-Ernst J, Stehle A, Vallon V, Quast U, Russ U. PMID: 18322364; PMCID: PMC2821438.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    133. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics. 2008 Apr 22; 33(2):180-92. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK. PMID: 18270321; PMCID: PMC3016923.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    134. Adenosine and kidney function: potential implications in patients with heart failure. Eur J Heart Fail. 2008 Feb; 10(2):176-87. Vallon V, Miracle C, Thomson S. PMID: 18242127; PMCID: PMC3151609.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    135. Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F867-73. Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK. PMID: 18216144.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    136. Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F638-44. Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA, Vallon V. PMID: 18199602.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    137. P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F10-27. Vallon V. PMID: 17977905.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    138. Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney. Kidney Blood Press Res. 2007; 30(6):388-99. Miracle CM, Rieg T, Blantz RC, Vallon V, Thomson SC. PMID: 17890869; PMCID: PMC2814144.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    139. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1501-11. Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann J, Köhle C, Kloor D, Gleiter CH, Vallon V, Eltzschig HK, Osswald H. PMID: 17855480.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    140. Functional significance of channels and transporters expressed in the inner ear and kidney. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1187-208. Lang F, Vallon V, Knipper M, Wangemann P. PMID: 17670895.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimals
    141. The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. Kidney Int. 2007 Sep; 72(5):566-73. Rieg T, Vallon V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H. PMID: 17579662.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    142. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov; 21(13):3717-26. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. PMID: 17575258.
      View in: PubMed   Mentions: 106     Fields:    Translation:Animals
    143. Tubuloglomerular feedback responses of the downstream efferent resistance: unmasking a role for adenosine? Kidney Int. 2007 May; 71(9):837-9. Blantz RC, Vallon V. PMID: 17457327.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    144. Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha. J Clin Invest. 2007 Mar; 117(3):773-83. Zhang W, Xia X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone BC. PMID: 17332896; PMCID: PMC1804379.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    145. Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol. 2007 Jan 26; 555(2-3):174-7. Rieg T, Schnermann J, Vallon V. PMID: 17126319.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    146. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev. 2006 Oct; 86(4):1151-78. Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. PMID: 17015487.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansAnimals
    147. Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1264-73. Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, Rajamanickam J, Palmada M, Wulff P, Kuhl D, Vallon V, Lang F. PMID: 17003223.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    148. Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. J Mol Med (Berl). 2006 Sep; 84(9):737-46. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D, Lang F. PMID: 16924469.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    149. Adenosine and kidney function. Physiol Rev. 2006 Jul; 86(3):901-40. Vallon V, Mühlbauer B, Osswald H. PMID: 16816141.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimals
    150. Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance. Diabetes. 2006 Jul; 55(7):2059-66. Boini KM, Hennige AM, Huang DY, Friedrich B, Palmada M, Boehmer C, Grahammer F, Artunc F, Ullrich S, Avram D, Osswald H, Wulff P, Kuhl D, Vallon V, Häring HU, Lang F. PMID: 16804076.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    151. Primary kidney growth and its consequences at the onset of diabetes mellitus. Amino Acids. 2006 Jul; 31(1):1-9. Satriano J, Vallon V. PMID: 16733619.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    152. Renal Ca2+ handling in sgk1 knockout mice. Pflugers Arch. 2006 Jul; 452(4):444-52. Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B, Vallon V, Wulff P, Kuhl D, Palmada M, Lang F. PMID: 16685564.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    153. SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med (Berl). 2006 May; 84(5):396-404. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F, Belaiba RS, Görlach A, Wulff P, Daut J, Dalton ND, Ross J, Flögel U, Schrader J, Osswald H, Kandolf R, Kuhl D, Lang F. PMID: 16604333.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    154. An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest. 2006 Apr; 116(4):1110-6. Thomson SC, Deng A, Wead L, Richter K, Blantz RC, Vallon V. PMID: 16557296; PMCID: PMC1409739.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    155. DOCA-induced phosphorylation of glycogen synthase kinase 3beta. Cell Physiol Biochem. 2006; 17(3-4):137-44. Wyatt AW, Hussain A, Amann K, Klingel K, Kandolf R, Artunc F, Grahammer F, Huang DY, Vallon V, Kuhl D, Lang F. PMID: 16543730.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    156. Ecto-5'-nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F282-8. Huang DY, Vallon V, Zimmermann H, Koszalka P, Schrader J, Osswald H. PMID: 16525161.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    157. Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl-induced metabolic acidosis. Kidney Blood Press Res. 2006; 29(1):36-42. Yao LJ, Leitges M, Vallon V. PMID: 16582576.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    158. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem. 2006 Feb 24; 281(8):5072-83. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK. PMID: 16354673.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    159. KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17864-9. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F. PMID: 16314573; PMCID: PMC1308898.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    160. Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. Am J Physiol Regul Integr Comp Physiol. 2006 Apr; 290(4):R935-44. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff P, Kuhl D, Vallon V, Lang F. PMID: 16284089.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    161. Impaired ability to increase water excretion in mice lacking the taurine transporter gene TAUT. Pflugers Arch. 2006 Feb; 451(5):668-77. Huang DY, Boini KM, Lang PA, Grahammer F, Duszenko M, Heller-Stilb B, Warskulat U, Häussinger D, Lang F, Vallon V. PMID: 16249932.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    162. Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins. J Am Soc Nephrol. 2005 Nov; 16(11):3160-6. Hummler E, Vallon V. PMID: 16192419.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    163. SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol Regul Integr Comp Physiol. 2005 Aug; 289(2):R395-R401. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F. PMID: 16014448.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    164. Expression and insights on function of potassium channel TWIK-1 in mouse kidney. Pflugers Arch. 2005 Dec; 451(3):479-88. Nie X, Arrighi I, Kaissling B, Pfaff I, Mann J, Barhanin J, Vallon V. PMID: 16025300.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    165. Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest. 2005 Jun; 115(6):1651-8. Nijenhuis T, Vallon V, van der Kemp AW, Loffing J, Hoenderop JG, Bindels RJ. PMID: 15902302; PMCID: PMC1090474.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    166. The salt paradox and its possible implications in managing hypertensive diabetic patients. Curr Hypertens Rep. 2005 Apr; 7(2):141-7. Vallon V, Blantz R, Thomson S. PMID: 15748540.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    167. Transport regulation by the serum- and glucocorticoid-inducible kinase SGK1. Biochem Soc Trans. 2005 Feb; 33(Pt 1):213-5. Lang F, Vallon V, Grahammer F, Palmada M, Böhmer C. PMID: 15667310.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    168. Role of Sgk1 in salt and potassium homeostasis. Am J Physiol Regul Integr Comp Physiol. 2005 Jan; 288(1):R4-10. Vallon V, Wulff P, Huang DY, Loffing J, Völkl H, Kuhl D, Lang F. PMID: 15590995.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    169. New insights into the role of serum- and glucocorticoid-inducible kinase SGK1 in the regulation of renal function and blood pressure. Curr Opin Nephrol Hypertens. 2005 Jan; 14(1):59-66. Vallon V, Lang F. PMID: 15586017.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    170. Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine. J Pharmacol Exp Ther. 2005 Apr; 313(1):403-9. Rieg T, Steigele H, Schnermann J, Richter K, Osswald H, Vallon V. PMID: 15590766.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    171. Kidney function in mice: thiobutabarbital versus alpha-chloralose anesthesia. Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct; 370(4):320-3. Rieg T, Richter K, Osswald H, Vallon V. PMID: 15549274.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    172. Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol. 2004 Sep; 15(9):2276-88. Loffing J, Vallon V, Loffing-Cueni D, Aregger F, Richter K, Pietri L, Bloch-Faure M, Hoenderop JG, Shull GE, Meneton P, Kaissling B. PMID: 15339977.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    173. Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol. 2004 Apr; 15(4):885-91. Huang DY, Wulff P, Völkl H, Loffing J, Richter K, Kuhl D, Lang F, Vallon V. PMID: 15034090.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    174. Immunolocalization of protein kinase C isoenzymes alpha, beta I, beta II, delta, and epsilon in mouse kidney. Am J Physiol Renal Physiol. 2004 Aug; 287(2):F289-98. Redling S, Pfaff IL, Leitges M, Vallon V. PMID: 15039141.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    175. Evidence for a role of protein kinase C-alpha in urine concentration. Am J Physiol Renal Physiol. 2004 Aug; 287(2):F299-304. Yao L, Huang DY, Pfaff IL, Nie X, Leitges M, Vallon V. PMID: 15039142.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    176. Functional consequences at the single-nephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice. Pflugers Arch. 2004 May; 448(2):214-21. Vallon V, Richter K, Huang DY, Rieg T, Schnermann J. PMID: 14767772.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    177. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Renal Physiol. 2004 Jan; 286(1):F8-15. Thomson SC, Vallon V, Blantz RC. PMID: 14656757.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    178. Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest. 2003 Dec; 112(12):1906-14. Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, van der Kemp AW, Mérillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJ. PMID: 14679186; PMCID: PMC297001.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    179. Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice. Behav Brain Res. 2003 Oct 17; 145(1-2):179-88. Lang UE, Lang F, Richter K, Vallon V, Lipp HP, Schnermann J, Wolfer DP. PMID: 14529816.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    180. Tubuloglomerular feedback and the control of glomerular filtration rate. News Physiol Sci. 2003 Aug; 18:169-74. Vallon V. PMID: 12869618.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    181. Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view. J Am Soc Nephrol. 2003 Feb; 14(2):530-7. Vallon V, Blantz RC, Thomson S. PMID: 12538755.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    182. Blunted apoptosis of erythrocytes from taurine transporter deficient mice. Cell Physiol Biochem. 2003; 13(6):337-46. Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang F, Häussinger D, Vallon V, Wieder T. PMID: 14631140.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    183. Regulation of channels by the serum and glucocorticoid-inducible kinase - implications for transport, excitability and cell proliferation. Cell Physiol Biochem. 2003; 13(1):41-50. Lang F, Henke G, Embark HM, Waldegger S, Palmada M, Böhmer C, Vallon V. PMID: 12649601.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    184. The salt paradox of the early diabetic kidney is independent of renal innervation. Kidney Blood Press Res. 2003; 26(5-6):344-50. Birk C, Richter K, Huang DY, Piesch C, Luippold G, Vallon V. PMID: 14610339.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    185. Tubuloglomerular feedback. Methods Mol Med. 2003; 86:429-41. Vallon V, Schnermann J. PMID: 12886786.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    186. In vivo studies of the genetically modified mouse kidney. Nephron Physiol. 2003; 94(1):p1-5. Vallon V. PMID: 12806203.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    187. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Pflugers Arch. 2003 Feb; 445(5):601-6. Embark HM, Böhmer C, Vallon V, Luft F, Lang F. PMID: 12634932.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    188. Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest. 2002 Nov; 110(9):1263-8. Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K, Jansen M, Schlünz M, Klingel K, Loffing J, Kauselmann G, Bösl MR, Lang F, Kuhl D. PMID: 12417564; PMCID: PMC151609.
      View in: PubMed   Mentions: 148     Fields:    Translation:Animals
    189. Tubuloglomerular feedback in the kidney: insights from gene-targeted mice. Pflugers Arch. 2003 Jan; 445(4):470-6. Vallon V. PMID: 12548391.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    190. Salt-sensitivity of proximal reabsorption alters macula densa salt and explains the paradoxical effect of dietary salt on glomerular filtration rate in diabetes mellitus. J Am Soc Nephrol. 2002 Jul; 13(7):1865-71. Vallon V, Huang DY, Deng A, Richter K, Blantz RC, Thomson S. PMID: 12089382.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    191. The complex role of nitric oxide in the regulation of glomerular ultrafiltration. Kidney Int. 2002 Mar; 61(3):782-5. Blantz RC, Deng A, Lortie M, Munger K, Vallon V, Gabbai FB, Thomson SC. PMID: 11849425.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    192. Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril. Kidney Blood Press Res. 2002; 25(5):329-40. Pfaff IL, Vallon V. PMID: 12435880.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    193. Human C-peptide acutely lowers glomerular hyperfiltration and proteinuria in diabetic rats: a dose-response study. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jan; 365(1):67-73. Huang DY, Richter K, Breidenbach A, Vallon V. PMID: 11862335.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    194. Role of KCNE1-dependent K+ fluxes in mouse proximal tubule. J Am Soc Nephrol. 2001 Oct; 12(10):2003-2011. Vallon V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, Völkl H, Warth R. PMID: 11562398.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    195. Feedback control of glomerular vascular tone in neuronal nitric oxide synthase knockout mice. J Am Soc Nephrol. 2001 Aug; 12(8):1599-1606. Vallon V, Traynor T, Barajas L, Huang YG, Briggs JP, Schnermann J. PMID: 11461931.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    196. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest. 2001 Jan; 107(2):217-24. Thomson SC, Deng A, Bao D, Satriano J, Blantz RC, Vallon V. PMID: 11160138; PMCID: PMC199175.
      View in: PubMed   Mentions: 96     Fields:    Translation:Animals
    197. Acute renal response to the non-peptide vasopressin V2-receptor antagonist SR 121463B in anesthetized rats. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep; 362(3):201-7. Huang DY, Pfaff I, Serradeil-Le Gal C, Vallon V. PMID: 10997721.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    198. Sodium reabsorption in thick ascending limb of Henle's loop: effect of potassium channel blockade in vivo. Br J Pharmacol. 2000 Jul; 130(6):1255-62. Huang DY, Osswald H, Vallon V. PMID: 10903963; PMCID: PMC1572189.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    199. Adenosine formed by 5'-nucleotidase mediates tubuloglomerular feedback. J Clin Invest. 2000 Jul; 106(2):289-98. Thomson S, Bao D, Deng A, Vallon V. PMID: 10903345; PMCID: PMC314305.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    200. Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. Am J Physiol Renal Physiol. 2000 Jun; 278(6):F1030-3. Vallon V, Verkman AS, Schnermann J. PMID: 10836992.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    201. Postglomerular vasoconstriction induced by dopamine D(3) receptor activation in anesthetized rats. Am J Physiol Renal Physiol. 2000 Apr; 278(4):F570-5. Luippold G, Schneider S, Vallon V, Osswald H, Mühlbauer B. PMID: 10751217.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    202. Role of Na(+)/H(+) exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3. Am J Physiol Renal Physiol. 2000 Mar; 278(3):F375-9. Vallon V, Schwark JR, Richter K, Hropot M. PMID: 10710541.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    203. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol. 1999 Dec; 10(12):2569-76. Vallon V, Richter K, Blantz RC, Thomson S, Osswald H. PMID: 10589696.
      View in: PubMed   Mentions: 156     Fields:    Translation:Animals
    204. Immunolocalization of protein kinase C isoenzymes alpha, beta1 and betaII in rat kidney. J Am Soc Nephrol. 1999 Sep; 10(9):1861-73. Pfaff IL, Wagner HJ, Vallon V. PMID: 10477137.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    205. Eukaliuric diuresis and natriuresis in response to the KATP channel blocker U37883A: micropuncture studies on the tubular site of action. Br J Pharmacol. 1999 Aug; 127(8):1811-8. Huang DY, Osswald H, Vallon V. PMID: 10482911; PMCID: PMC1566186.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    206. Dopamine D3 receptors in the rat kidney: glomerular and tubular actions. Nephrol Dial Transplant. 1999; 14 Suppl 4:24-5. Luippold G, Küster E, Vallon V, Osswald H, Mühlbauer B. PMID: 10463201.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    207. Intratubular application of sodium azide inhibits loop of Henle reabsorption and tubuloglomerular feedback response in anesthetized rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep; 358(3):367-73. Huang DY, Osswald H, Vallon V. PMID: 9774225.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    208. Effect of KATP channel blocker U37883A on renal function in experimental diabetes mellitus in rats. J Pharmacol Exp Ther. 1998 Sep; 286(3):1215-21. Vallon V, Albinus M, Blach D. PMID: 9732381.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    209. Resetting protects efficiency of tubuloglomerular feedback. Kidney Int Suppl. 1998 Sep; 67:S65-70. Thomson SC, Vallon V, Blantz RC. PMID: 9736256.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    210. Luminal signal in tubuloglomerular feedback: what about potassium? Kidney Int Suppl. 1998 Sep; 67:S177-9. Vallon V, Osswald H, Blantz RC, Thomson S. PMID: 9736282.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    211. Eukaliuric natriuresis and diuresis in response to disprocynium24: studies on the tubular site of action. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug; 358(2):238-44. Vallon V, Richter K, Osswald H, Schömig E, Mühlbauer B. PMID: 9750010.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    212. Potassium diet as a determinant for the renal response to systemic potassium channel modulation in anesthetized rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug; 358(2):245-52. Vallon V, Kirschenmann D, Brenner I, Albinus M, Osswald H. PMID: 9750011.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    213. [7-D-ALA]-angiotensin 1-7 blocks renal actions of angiotensin 1-7 in the anesthetized rat. J Cardiovasc Pharmacol. 1998 Jul; 32(1):164-7. Vallon V, Heyne N, Richter K, Khosla MC, Fechter K. PMID: 9676737.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    214. Disprocynium24 induces a dopamine-independent, eukaliuric diuresis and natriuresis in the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec; 356(6):846-9. Mühlbauer B, Luippold G, Vallon V, Spitzenberger F, Russ H, Osswald H, Schömig E. PMID: 9453472.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    215. Potential role of luminal potassium in tubuloglomerular feedback. J Am Soc Nephrol. 1997 Dec; 8(12):1831-7. Vallon V, Osswald H, Blantz RC, Thomson S. PMID: 9402084.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    216. Reduced proximal reabsorption resets tubuloglomerular feedback in euvolemic rats. Am J Physiol. 1997 10; 273(4):R1414-20. Thomson SC, Vallon V, Blantz RC. PMID: 9362307.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    217. Effect of chronic salt loading on kidney function in early and established diabetes mellitus in rats. J Lab Clin Med. 1997 Jul; 130(1):76-82. Vallon V, Kirschenmann D, Wead LM, Lortie MJ, Satriano J, Blantz RC, Thomson SC. PMID: 9242369.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    218. Adenosine and tubuloglomerular feedback. Blood Purif. 1997; 15(4-6):243-52. Osswald H, Mühlbauer B, Vallon V. PMID: 9435952.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    219. Effect of intratubular application of angiotensin 1-7 on nephron function. Kidney Blood Press Res. 1997; 20(4):233-9. Vallon V, Richter K, Heyne N, Osswald H. PMID: 9398028.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    220. Asymmetry of tubuloglomerular feedback effector mechanism with respect to ambient tubular flow. Am J Physiol. 1996 Dec; 271(6 Pt 2):F1123-30. Thomson S, Vallon V, Blantz RC. PMID: 8997385.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    221. Role of adenosine in tubuloglomerular feedback and acute renal failure. J Auton Pharmacol. 1996 Dec; 16(6):377-80. Osswald H, Vallon V, Mühlbauer B. PMID: 9131420.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    222. Activities of nitric oxide in normal physiology and uremia. Semin Nephrol. 1996 May; 16(3):144-50. Blantz RC, Lortie M, Vallon V, Gabbai FB, Parmer RJ, Thomson S. PMID: 8734457.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    223. Increased tubular flow induces resetting of tubuloglomerular feedback in euvolemic rats. Am J Physiol. 1996 Mar; 270(3 Pt 2):F461-8. Thomson SC, Blantz RC, Vallon V. PMID: 8780249.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    224. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. J Clin Invest. 1996 Jan 15; 97(2):413-20. Lortie MJ, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, Satriano J, Insel P, Thomson SC, Blantz RC. PMID: 8567962; PMCID: PMC507032.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    225. Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats. Am J Physiol. 1995 Dec; 269(6 Pt 2):F876-83. Vallon V, Blantz RC, Thomson S. PMID: 8594883.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    226. Interactive control of renal function by alpha 2-adrenergic system and nitric oxide: role of angiotensin II. J Cardiovasc Pharmacol. 1995 Dec; 26(6):916-22. Vallon V, Peterson OW, Gabbai FB, Blantz RC, Thomson SC. PMID: 8606528.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    227. Inhibition of local nitric oxide synthase increases homeostatic efficiency of tubuloglomerular feedback. Am J Physiol. 1995 Dec; 269(6 Pt 2):F892-9. Vallon V, Thomson S. PMID: 8594885.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    228. Alpha 2-adrenoceptors determine the response to nitric oxide inhibition in the rat glomerulus and proximal tubule. J Am Soc Nephrol. 1995 Nov; 6(5):1482-90. Thomson SC, Vallon V. PMID: 8589327.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    229. Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats: effect of sodium and salt restriction. J Am Soc Nephrol. 1995 Apr; 5(10):1761-7. Vallon V, Wead LM, Blantz RC. PMID: 7787143.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    230. Dipyridamole prevents diabetes-induced alterations of kidney function in rats. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb; 349(2):217-22. Vallon V, Osswald H. PMID: 8170506.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
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