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Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics. Nat Cardiovasc Res. 2023 Dec; 2(12):1246-1261.
Bradford WH, Zhang J, Gutierrez-Lara EJ, Liang Y, Do A, Wang TM, Nguyen L, Mataraarachchi N, Wang J, Gu Y, McCulloch A, Peterson KL, Sheikh F. PMID: 39196150; PMCID: PMC11357983.
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PubMed Mentions:
7 Translation:
HumansAnimalsCells
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Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct. Circulation. 2023 01 10; 147(2):183-186.
Yu Z, Zhang L, Cattaneo P, Guimarães-Camboa N, Fang X, Gu Y, Peterson KL, Bogomolovas J, Cuitino C, Leone GW, Chen J, Evans SM. PMID: 36622904; PMCID: PMC9988404.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle. Circulation. 2022 02 22; 145(8):586-602.
Wu T, Liang Z, Zhang Z, Liu C, Zhang L, Gu Y, Peterson KL, Evans SM, Fu XD, Chen J. PMID: 34915728; PMCID: PMC8860879.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol. 2022 06; 179(11):2413-2429.
Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB. PMID: 34000062; PMCID: PMC9926932.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 06 01; 131(11).
Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. PMID: 33857019; PMCID: PMC8159691.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction. Circulation. 2020 07 28; 142(4):365-379.
Tang X, Miao Y, Luo Y, Sriram K, Qi Z, Lin FM, Gu Y, Lai CH, Hsu CY, Peterson KL, Van Keuren-Jensen K, Fueger PT, Yeo GW, Natarajan R, Zhong S, Chen ZB. PMID: 32393053; PMCID: PMC7390348.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res. 2020 07 03; 127(2):284-297.
Zhang J, Vincent KP, Peter AK, Klos M, Cheng H, Huang SM, Towne JK, Ferng D, Gu Y, Dalton ND, Chan Y, Li R, Peterson KL, Chen J, McCulloch AD, Knowlton KU, Ross RS. PMID: 32345129; PMCID: PMC7571547.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease. Sci Transl Med. 2020 03 18; 12(535).
Manso AM, Hashem SI, Nelson BC, Gault E, Soto-Hermida A, Villarruel E, Brambatti M, Bogomolovas J, Bushway PJ, Chen C, Battiprolu P, Keravala A, Schwartz JD, Shah G, Gu Y, Dalton ND, Hammond K, Peterson K, Saftig P, Adler ED. PMID: 32188720.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019 09 12; 4(19).
Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V. PMID: 31513548; PMCID: PMC6795397.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 08 06; 10(1):3533.
Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. PMID: 31387997; PMCID: PMC6684604.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. 2019 07 02; 140(1):55-66.
Liu C, Spinozzi S, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimarães-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM, Chen J. PMID: 30982350; PMCID: PMC6889818.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Combinatorial interactions of genetic variants in human cardiomyopathy. Nat Biomed Eng. 2019 02; 3(2):147-157.
Deacon DC, Happe CL, Chen C, Tedeschi N, Manso AM, Li T, Dalton ND, Peng Q, Farah EN, Gu Y, Tenerelli KP, Tran VD, Chen J, Peterson KL, Schork NJ, Adler ED, Engler AJ, Ross RS, Chi NC. PMID: 30923642; PMCID: PMC6433174.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 01 01; 115(1):179-189.
Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. PMID: 29850765; PMCID: PMC6302283.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure. Elife. 2018 12 06; 7.
Pollak AJ, Liu C, Gudlur A, Mayfield JE, Dalton ND, Gu Y, Chen J, Heller Brown J, Hogan PG, Wiley SE, Peterson KL, Dixon JE. PMID: 30520731; PMCID: PMC6298778.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43.
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
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PubMed Mentions:
2 Fields:
-
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306.
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
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PubMed Mentions:
212 Fields:
Translation:
AnimalsCells
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Luma is not essential for murine cardiac development and function. Cardiovasc Res. 2018 Mar 01; 114(3):378-388.
Stroud MJ, Fang X, Zhang J, Guimarães-Camboa N, Veevers J, Dalton ND, Gu Y, Bradford WH, Peterson KL, Evans SM, Gerace L, Chen J. PMID: 29040414; PMCID: PMC6019056.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages. Circ Res. 2018 02 16; 122(4):583-590.
Moore-Morris T, Cattaneo P, Guimarães-Camboa N, Bogomolovas J, Cedenilla M, Banerjee I, Ricote M, Kisseleva T, Zhang L, Gu Y, Dalton ND, Peterson KL, Chen J, Pucéat M, Evans SM. PMID: 29269349; PMCID: PMC5815911.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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A novel method for quantitative myocardial contrast echocardiography in mice. Am J Physiol Heart Circ Physiol. 2018 02 01; 314(2):H370-H379.
Alvarez E, Dalton ND, Gu Y, Smith D, Luong A, Hoshijima M, Peterson KL, Rychak J. PMID: 29127239; PMCID: PMC5867659.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. PMID: 28737513; PMCID: PMC5531406.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Impaired mitophagy facilitates mitochondrial damage in Danon disease. J Mol Cell Cardiol. 2017 07; 108:86-94.
Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED. PMID: 28526246.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 03 02; 20(3):345-359.e5.
Guimarães-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM. PMID: 28111199; PMCID: PMC5337131.
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PubMed Mentions:
235 Fields:
Translation:
HumansCells
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Adipocyte-specific loss of PPARγ attenuates cardiac hypertrophy. JCI Insight. 2016 Oct 06; 1(16):e89908.
Fang X, Stroud MJ, Ouyang K, Fang L, Zhang J, Dalton ND, Gu Y, Wu T, Peterson KL, Huang HD, Chen J, Wang N. PMID: 27734035; PMCID: PMC5053146.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis. PLoS One. 2016; 11(8):e0159971.
Peter AK, Bradford WH, Dalton ND, Gu Y, Chao CJ, Peterson KL, Knowlton KU. PMID: 27486657; PMCID: PMC4972301.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 08; 9(8).
Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton KU, Ross RS, Zhou X, Chen J. PMID: 27502369; PMCID: PMC4979611.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016 06 30; 7:12088.
Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M. PMID: 27357444; PMCID: PMC4931341.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Nat Commun. 2016 06 29; 7:12120.
Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. PMID: 27353086; PMCID: PMC4931343.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016 08 01; 111(3):274-86.
Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. PMID: 27097650; PMCID: PMC4957488.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Selective Life-Long Skeletal Myofiber-Targeted VEGF Gene Ablation Impairs Exercise Capacity in Adult Mice. J Cell Physiol. 2016 Feb; 231(2):505-11.
Tang K, Gu Y, Dalton ND, Wagner H, Peterson KL, Wagner PD, Breen EC. PMID: 26201683.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Lmo7 is dispensable for skeletal muscle and cardiac function. Am J Physiol Cell Physiol. 2015 Oct 01; 309(7):C470-9.
Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton KU, Peterson KL, Lieber RL, Chen J. PMID: 26157009; PMCID: PMC4593772.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15; 107(2):216-25.
Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML. PMID: 25987543; PMCID: PMC4565986.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Normalization of Naxos plakoglobin levels restores cardiac function in mice. J Clin Invest. 2015 Apr; 125(4):1708-12.
Zhang Z, Stroud MJ, Zhang J, Fang X, Ouyang K, Kimura K, Mu Y, Dalton ND, Gu Y, Bradford WH, Peterson KL, Cheng H, Zhou X, Chen J. PMID: 25705887; PMCID: PMC4396479.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39.
Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649; PMCID: PMC4344921.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 01; 307(5):H773-81.
Cowling RT, Yeo SJ, Kim IJ, Park JI, Gu Y, Dalton ND, Peterson KL, Greenberg BH. PMID: 24993042; PMCID: PMC4187391.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34.
Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans SM. PMID: 24937432; PMCID: PMC4071409.
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PubMed Mentions:
337 Fields:
Translation:
AnimalsCells
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The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. PLoS One. 2014; 9(4):e93638.
Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. PMID: 24736439; PMCID: PMC3988038.
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PubMed Mentions:
42 Fields:
Translation:
Animals
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Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 01; 23(5):1134-50.
Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, Sheikh F. PMID: 24108106; PMCID: PMC3919010.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704.
Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC. PMID: 23990245; PMCID: PMC3882740.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation. J Appl Physiol (1985). 2013 May; 114(9):1340-50.
Tang K, Murano G, Wagner H, Nogueira L, Wagner PD, Tang A, Dalton ND, Gu Y, Peterson KL, Breen EC. PMID: 23449936; PMCID: PMC3656431.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB. Circ Res. 2013 Mar 15; 112(6):935-44.
Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown JH. PMID: 23388157; PMCID: PMC3673710.
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PubMed Mentions:
83 Fields:
Translation:
AnimalsCells
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Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 08; 288(6):4252-64.
Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS. PMID: 23266827; PMCID: PMC3567677.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr; 122(4):1209-21.
Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. PMID: 22426213; PMCID: PMC3314469.
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PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
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β1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses. Am J Pathol. 2012 Mar; 180(3):952-962.
Li R, Wu Y, Manso AM, Gu Y, Liao P, Israeli S, Yajima T, Nguyen U, Huang MS, Dalton ND, Peterson KL, Ross RS. PMID: 22248583; PMCID: PMC3349893.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 03; 110(3):456-64.
Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. PMID: 22158707; PMCID: PMC3739283.
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PubMed Mentions:
36 Fields:
Translation:
Animals
-
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest. 2011 Dec; 121(12):4640-54.
Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM. PMID: 22080862; PMCID: PMC3223071.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation. 2011 Dec 13; 124(24):2690-701.
Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton KU. PMID: 22082679; PMCID: PMC3253669.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011 Nov; 7(11):e1002344.
Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. PMID: 22072978; PMCID: PMC3207880.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One. 2011; 6(6):e21571.
Rane AA, Chuang JS, Shah A, Hu DP, Dalton ND, Gu Y, Peterson KL, Omens JH, Christman KL. PMID: 21731777; PMCID: PMC3121880.
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PubMed Mentions:
44 Fields:
Translation:
Animals
-
Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62.
Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. PMID: 21303826; PMCID: PMC3071671.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity. Endocrinology. 2010 Oct; 151(10):4820-9.
Gu Y, Zhang K, Biswas N, Friese RS, Lin DH, Mahata SK, Hoshijima M, O'Connor DT, Peterson KL, Brar BK. PMID: 20668031; PMCID: PMC2946150.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16.
Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. PMID: 20644257; PMCID: PMC2912201.
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PubMed Mentions:
200 Fields:
Translation:
AnimalsCells
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Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 06; 107(3):348-56.
Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, Chen J. PMID: 20538684; PMCID: PMC3684396.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Effects of ACE2 inhibition in the post-myocardial infarction heart. J Card Fail. 2010 Sep; 16(9):777-85.
Kim MA, Yang D, Kida K, Molotkova N, Yeo SJ, Varki N, Iwata M, Dalton ND, Peterson KL, Siems WE, Walther T, Cowling RT, Kjekshus J, Greenberg B. PMID: 20797602; PMCID: PMC2929397.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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Acute effects of urocortin 2 on cardiac function and propensity for arrhythmias in an animal model of hypertension-induced left ventricular hypertrophy and heart failure. Eur J Heart Fail. 2010 Aug; 12(8):797-804.
Meili-Butz S, Bühler K, John D, Buser P, Vale WW, Peterson KL, Brink M, Dieterle T. PMID: 20388649.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Pulmonary artery pressure responses to increased cardiac output in chickens with raised metabolic rate. Comp Biochem Physiol A Mol Integr Physiol. 2010 Aug; 156(4):430-5.
West JB, Fu Z, Gu Y, Wagner HE, Carr JA, Peterson KL. PMID: 20363353; PMCID: PMC2892207.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010 Feb 05; 106(2):354-62.
Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. PMID: 19959778; PMCID: PMC2818826.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15; 19(2):329-41.
Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. PMID: 19864491; PMCID: PMC2796894.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ. 2009 Dec; 16(12):1590-8.
Elia L, Quintavalle M, Zhang J, Contu R, Cossu L, Latronico MV, Peterson KL, Indolfi C, Catalucci D, Chen J, Courtneidge SA, Condorelli G. PMID: 19816508; PMCID: PMC3014107.
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PubMed Mentions:
277 Fields:
Translation:
HumansAnimalsCells
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Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009 Aug 18; 120(7):568-76.
Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM, Chen J. PMID: 19652092; PMCID: PMC2738591.
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34 Fields:
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AnimalsCells
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Spontaneous recanalization of a completely occluded saphenous vein graft two months following acute myocardial infarction with persistent one year patency. J Thromb Thrombolysis. 2009 Jul; 28(1):101-5.
Hu PP, Peterson KL, Tsimikas S. PMID: 19396586; PMCID: PMC2694324.
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Humans
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Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May; 119(5):1230-40.
Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH, Heller Brown J. PMID: 19381018; PMCID: PMC2673879.
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206 Fields:
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AnimalsCells
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Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009 Mar 23; 184(6):923-33.
Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. PMID: 19307602; PMCID: PMC2699149.
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60 Fields:
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AnimalsCells
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Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol. 2009 Apr 15; 587(Pt 8):1755-67.
Olfert IM, Howlett RA, Tang K, Dalton ND, Gu Y, Peterson KL, Wagner PD, Breen EC. PMID: 19237429; PMCID: PMC2683962.
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70 Fields:
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AnimalsCells
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Immediate and sustained blood pressure lowering by urocortin 2: a novel approach to antihypertensive therapy? Hypertension. 2009 Apr; 53(4):739-44.
Dieterle T, Meili-Butz S, Bühler K, Morandi C, John D, Buser PT, Rivier J, Vale WW, Peterson KL, Brink M. PMID: 19204182.
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PubMed Mentions:
8 Fields:
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Animals
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Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet. 2009 Feb 15; 18(4):701-13.
Zheng M, Cheng H, Li X, Zhang J, Cui L, Ouyang K, Han L, Zhao T, Gu Y, Dalton ND, Bang ML, Peterson KL, Chen J. PMID: 19028670; PMCID: PMC2722217.
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58 Fields:
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HumansAnimalsCells
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An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80.
Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658; PMCID: PMC2575833.
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138 Fields:
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AnimalsCells
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Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70.
Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. PMID: 18636119; PMCID: PMC2467382.
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65 Fields:
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HumansAnimalsCells
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Syncoilin is required for generating maximum isometric stress in skeletal muscle but dispensable for muscle cytoarchitecture. Am J Physiol Cell Physiol. 2008 May; 294(5):C1175-82.
Zhang J, Bang ML, Gokhin DS, Lu Y, Cui L, Li X, Gu Y, Dalton ND, Scimia MC, Peterson KL, Lieber RL, Chen J. PMID: 18367591; PMCID: PMC2749034.
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PubMed Mentions:
14 Fields:
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AnimalsCells
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MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007 May; 13(5):613-8.
Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G. PMID: 17468766.
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803 Fields:
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HumansAnimals
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erbB2 is required for G protein-coupled receptor signaling in the heart. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15889-93.
Negro A, Brar BK, Gu Y, Peterson KL, Vale W, Lee KF. PMID: 17043217; PMCID: PMC1635098.
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19 Fields:
Translation:
AnimalsCells
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alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 05; 114(10):1046-55.
Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, Chen J. PMID: 16923756.
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52 Fields:
Translation:
AnimalsCells
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Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science. 2006 Jul 07; 313(5783):94-7.
Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton KU, Chesebro B, Oldstone MB. PMID: 16825571; PMCID: PMC1820586.
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PubMed Mentions:
28 Fields:
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Animals
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Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure. Cardiovasc Res. 2005 Sep 01; 67(4):678-88.
Dieterle T, Meyer M, Gu Y, Belke DD, Swanson E, Iwatate M, Hollander J, Peterson KL, Ross J, Dillmann WH. PMID: 15927173.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Severe calcific aortic stenosis left ventricular afterload and its quantification. J Am Coll Cardiol. 2005 Jul 19; 46(2):299-301.
Peterson KL. PMID: 16022958.
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Humans
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Cardiac catheterization techniques in pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):401-15, vi.
Guillinta P, Peterson KL, Ben-Yehuda O. PMID: 15302360.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest. 2004 Mar; 113(5):727-36.
Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J. PMID: 14991071; PMCID: PMC351313.
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PubMed Mentions:
54 Fields:
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AnimalsCells
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The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3697-702.
Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. PMID: 14990799; PMCID: PMC373525.
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PubMed Mentions:
39 Fields:
Translation:
Animals
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A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. FASEB J. 2004 Mar; 18(3):587-8.
Iwanaga Y, Gu Y, Dieterle T, Presotto C, Del Soldato P, Peterson KL, Ongini E, Condorelli G, Ross J. PMID: 14734637.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart. Gene Ther. 2003 Oct; 10(21):1814-20.
Iwatate M, Gu Y, Dieterle T, Iwanaga Y, Peterson KL, Hoshijima M, Chien KR, Ross J. PMID: 12960971.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function. J Mol Cell Cardiol. 2003 Jun; 35(6):661-70.
Yao M, Dieterle T, Hale SL, Dow JS, Kedes LH, Peterson KL, Kloner RA. PMID: 12788384.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11375-80.
Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J, Chien KR. PMID: 12177436; PMCID: PMC123264.
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PubMed Mentions:
216 Fields:
Translation:
Animals
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Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7734-9.
Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF. PMID: 12032352; PMCID: PMC124337.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May; 8(5):459-65.
Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR, Lee KF. PMID: 11984589.
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295 Fields:
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HumansAnimalsCells
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Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation. 2002 Apr 09; 105(14):1720-6.
Müller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW, Kloner RA. PMID: 11940553.
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42 Fields:
Translation:
AnimalsCells
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Pressure overload hypertrophy and congestive heart failure. Where is the "Achilles' heel"? J Am Coll Cardiol. 2002 Feb 20; 39(4):672-5.
Peterson KL. PMID: 11849867.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 2002 Jan 29; 105(4):502-8.
Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross J. PMID: 11815435.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med. 2001 May; 7(5):591-7.
Pashmforoush M, Pomiès P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR. PMID: 11329061.
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PubMed Mentions:
64 Fields:
Translation:
Animals
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Altered membrane proteins and permeability correlate with cardiac dysfunction in cardiomyopathic hamsters. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1362-70.
Ikeda Y, Martone M, Gu Y, Hoshijima M, Thor A, Oh SS, Peterson KL, Ross J. PMID: 10749734.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. Circulation. 1999 Oct 19; 100(16):1734-43.
Ryoke T, Gu Y, Mao L, Hongo M, Clark RG, Peterson KL, Ross J. PMID: 10525494.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Force-frequency effect is a powerful determinant of myocardial contractility in the mouse. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1283-90.
Palakodeti V, Oh S, Oh BH, Mao L, Hongo M, Peterson KL, Ross J. PMID: 9321817.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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The influence of coronary collateral flow on the assessment of myocardial perfusion by videodensitometry. Cardiovasc Res. 1997 Feb; 33(2):359-69.
Murata K, Bhargava V, Ricou F, Ono S, Kambayashi M, Oh BH, Peterson KL. PMID: 9074700.
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Animals
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Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation. 1996 Sep 01; 94(5):1109-17.
Tanaka N, Dalton N, Mao L, Rockman HA, Peterson KL, Gottshall KR, Hunter JJ, Chien KR, Ross J. PMID: 8790053.
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110 Fields:
Translation:
Animals
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Atheroma morphology and distribution in proximal left anterior descending coronary artery: in vivo observations. J Am Coll Cardiol. 1996 Mar 15; 27(4):825-31.
Kimura BJ, Russo RJ, Bhargava V, McDaniel MB, Peterson KL, DeMaria AN. PMID: 8613610.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Role of intraaortic balloon pump counterpulsation in high risk coronary rotational atherectomy. J Am Coll Cardiol. 1995 Nov 01; 26(5):1270-5.
O'Murchu B, Foreman RD, Shaw RE, Brown DL, Peterson KL, Buchbinder M. PMID: 7594042.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Heterogeneity of vasomotor response to acetylcholine along the human coronary artery. J Am Coll Cardiol. 1995 Apr; 25(5):1046-55.
Penny WF, Rockman H, Long J, Bhargava V, Carrigan K, Ibriham A, Shabetai R, Ross J, Peterson KL. PMID: 7897115.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Increased afterload intensifies asynchronous wall motion and impairs ventricular relaxation. J Appl Physiol (1985). 1993 Jul; 75(1):389-96.
Miura T, Bhargava V, Guth BD, Sunnerhagen KS, Miyazaki S, Indolfi C, Peterson KL. PMID: 8376290.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Evaluation of inotropic effect of endothelin-1 in vivo. J Cardiovasc Pharmacol. 1992 Oct; 20(4):671-7.
Ricou FJ, Murata K, Oh BH, Kambayashi M, Peterson KL. PMID: 1280726.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Chronic major-vessel thromboembolic pulmonary artery obstruction: appearance at angiography. Radiology. 1992 Feb; 182(2):393-8.
Auger WR, Fedullo PF, Moser KM, Buchbinder M, Peterson KL. PMID: 1732955.
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PubMed Mentions:
49 Fields:
Translation:
Humans
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Right and left ventricular function after cardiac transplantation. Changes during and after rejection. Circulation. 1991 Dec; 84(6):2409-17.
Skowronski EW, Epstein M, Ota D, Hoagland PM, Gordon JB, Adamson RM, McDaniel M, Peterson KL, Smith SC, Jaski BE. PMID: 1959196.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Catheter-based intravascular ultrasound imaging of chronic thromboembolic pulmonary disease. Am J Cardiol. 1991 Apr 01; 67(8):749-52.
Ricou F, Nicod PH, Moser KM, Peterson KL. PMID: 2006626.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Intracoronary urokinase for intracoronary thrombus accumulation complicating percutaneous transluminal coronary angioplasty in acute ischemic syndromes. Circulation. 1990 Dec; 82(6):2052-60.
Schieman G, Cohen BM, Kozina J, Erickson JS, Podolin RA, Peterson KL, Ross J, Buchbinder M. PMID: 2242529.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Timing of cardiac surgery in chronic mitral valve disease: implications of natural history studies and left ventricular mechanics. Semin Thorac Cardiovasc Surg. 1989 Oct; 1(2):106-17.
Peterson KL. PMID: 2488415.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Familial aortic dissecting aneurysm. J Am Coll Cardiol. 1989 Mar 15; 13(4):811-9.
Nicod P, Bloor C, Godfrey M, Hollister D, Pyeritz RE, Dittrich H, Polikar R, Peterson KL. PMID: 2647812.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Early diastolic filling dynamics during experimental mitral regurgitation in the conscious dog. Circulation. 1988 Aug; 78(2):390-400.
Katayama K, Tajimi T, Guth BD, Matsuzaki M, Lee JD, Seitelberger R, Peterson KL. PMID: 3396176.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Temporal Fourier transform of digital angiograms for left ventricular regional wall motion analysis. Jpn Circ J. 1988 Jul; 52(7):607-16.
Katayama K, Guth BD, Widmann TF, Lee JD, Seitelberger R, Peterson KL. PMID: 3184433.
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Translation:
Animals
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Hypertrophic cardiomyopathy and sudden death. N Engl J Med. 1988 May 12; 318(19):1255-7.
Nicod P, Polikar R, Peterson KL. PMID: 3362178.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Early changes of right heart geometry after pulmonary thromboendarterectomy. J Am Coll Cardiol. 1988 May; 11(5):937-43.
Dittrich HC, Nicod PH, Chow LC, Chappuis FP, Moser KM, Peterson KL. PMID: 3356839.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Quantitative assessment of regional left ventricular function by densitometric analysis of digital-subtraction ventriculograms: correlation with myocardial systolic shortening in dogs. Circulation. 1988 Feb; 77(2):457-67.
Chappuis F, Widmann T, Guth B, Nicod P, Peterson KL. PMID: 3276410.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Densitometric regional ejection fraction: a new three-dimensional index of regional left ventricular function--comparison with geometric methods. J Am Coll Cardiol. 1988 Jan; 11(1):72-82.
Chappuis FP, Widmann TF, Nicod P, Peterson KL. PMID: 3275707.
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PubMed Mentions:
4 Fields:
Translation:
Humans