Christian Metallo

Title(s)Adjunct Professor, Bioengineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Non-essential amino acids and sphingolipid diversity in cancer progression
    NIH R01CA234245Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator
    Metabolic role of the neuronal Na+-dependent citrate transporter implicated in epilepsy
    NIH R21NS104513May 15, 2018 - Apr 30, 2021
    Role: Co-Principal Investigator
    Role of p62 in metabolic reprograming of the tumor stroma in prostate cancer
    NIH R01CA218254Aug 1, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Exploiting Metabloic Defects in Tumors with Mutant IDH1 and IDH2
    NIH R01CA188652Jul 1, 2014 - Jun 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 05; 10(14):eadl0389. Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. PMID: 38569044; PMCID: PMC10990287.
      View in: PubMed   Mentions:    Fields:    
    2. Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond. Cold Spring Harb Perspect Med. 2024 Mar 19. Lim EW, Metallo CM. PMID: 38503499.
      View in: PubMed   Mentions:    Fields:    
    3. Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection. bioRxiv. 2024 Mar 03. Greene TT, Jo Y, Macal M, Fang Z, Khatri FS, Codrington AL, Kazane KR, Chiale C, Akbulut E, Swaminathan S, Fujita Y, Fitzgerald-Bocarsly P, Cordes T, Metallo C, Scott DA, Zuniga EI. PMID: 38464328; PMCID: PMC10925345.
      View in: PubMed   Mentions:
    4. EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth. Cancer Discov. 2024 Jan 25; OF1-OF22. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. PMID: 38270272.
      View in: PubMed   Mentions:    Fields:    
    5. Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain. Prostaglandins Leukot Essent Fatty Acids. 2024 Jan 22; 201:102607. O'Sullivan A, Brady E, Lafferty L, O'Shea F, O'Regan Z, Meurs N, Baldini M, Gengatharan J, Metallo CM, Wallace M. PMID: 38277883.
      View in: PubMed   Mentions:    Fields:    
    6. EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. Cancer Discov. 2024 Jan 19. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteiza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. PMID: 38241033.
      View in: PubMed   Mentions:    Fields:    
    7. Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nat Commun. 2023 Dec 13; 14(1):8075. Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J. PMID: 38092754; PMCID: PMC10719313.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines. 2023 Oct 19; 11(10). Zhang J, Keibler MA, Dong W, Ghelfi J, Cordes T, Kanashova T, Pailot A, Linster CL, Dittmar G, Metallo CM, Lautenschlaeger T, Hiller K, Stephanopoulos G. PMID: 37893215; PMCID: PMC10604529.
      View in: PubMed   Mentions:
    9. Methionine and H2S alter cancer-immune dialogue. Nat Metab. 2023 09; 5(9):1456-1458. Joulia E, Metallo CM. PMID: 37537368.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Sources and Sinks of Serine in Nutrition, Health, and Disease. Annu Rev Nutr. 2023 08 21; 43:123-151. Handzlik MK, Metallo CM. PMID: 37307855; PMCID: PMC10783795.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress. Sci Adv. 2023 05 03; 9(18):eadf0138. Kuna RS, Kumar A, Wessendorf-Rodriguez KA, Galvez H, Green CR, McGregor GH, Cordes T, Shaw RJ, Svensson RU, Metallo CM. PMID: 37134162; PMCID: PMC10156121.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    12. iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function. J Clin Invest. 2023 05 01; 133(9). Eade KT, Ansell BRE, Giles S, Fallon R, Harkins-Perry S, Nagasaki T, Tzaridis S, Wallace M, Mills EA, Farashi S, Johnson A, Sauer L, Hart B, Diaz-Rubio ME, Bahlo M, Metallo C, Allikmets R, Gantner ML, Bernstein PS, Friedlander M. PMID: 37115691; PMCID: PMC10145939.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. EGFR + lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. bioRxiv. 2023 Apr 17. Kuhlmann-Hogan A, Cordes T, Xu Z, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy SR, Nobari M, Cheng GZ, Shaw R, Leibel SL, Metallo CM, Politi K, Kaech SM. PMID: 37131637; PMCID: PMC10153136.
      View in: PubMed   Mentions:
    14. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8). Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. PMID: 36821378; PMCID: PMC10104905.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease. Mol Metab. 2023 06; 72:101716. Green CR, Bonelli R, Ansell BRE, Tzaridis S, Handzlik MK, McGregor GH, Hart B, Trombley J, Reilly MM, Bernstein PS, Egan C, Fruttiger M, Wallace M, Bahlo M, Friedlander M, Metallo CM, Gantner ML. PMID: 36997154; PMCID: PMC10114224.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity. PNAS Nexus. 2023 Apr; 2(4):pgad105. Heyden KE, Fiddler JL, Xiu Y, Malysheva OV, Handzlik MK, Phinney WN, Stiles L, Stabler SP, Metallo CM, Caudill MA, Field MS. PMID: 37077889; PMCID: PMC10109189.
      View in: PubMed   Mentions:
    17. Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism. J Biol Chem. 2023 05; 299(5):104611. Trieger GW, Pessentheiner AR, Purcell SC, Green CR, DeForest N, Willert K, Majithia AR, Metallo CM, Godula K, Gordts PLSM. PMID: 36931394; PMCID: PMC10164900.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
      View in: PubMed   Mentions:    Fields:    
    19. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. Nature. 2023 02; 614(7946):118-124. Handzlik MK, Gengatharan JM, Frizzi KE, McGregor GH, Martino C, Rahman G, Gonzalez A, Moreno AM, Green CR, Guernsey LS, Lin T, Tseng P, Ideguchi Y, Fallon RJ, Chaix A, Panda S, Mali P, Wallace M, Knight R, Gantner ML, Calcutt NA, Metallo CM. PMID: 36697822; PMCID: PMC9891999.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    20. Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia. Nat Aging. 2022 12; 2(12):1159-1175. Laurila PP, Wohlwend M, Imamura de Lima T, Luan P, Herzig S, Zanou N, Crisol B, Bou-Sleiman M, Porcu E, Gallart-Ayala H, Handzlik MK, Wang Q, Jain S, D'Amico D, Salonen M, Metallo CM, Kutalik Z, Eichmann TO, Place N, Ivanisevic J, Lahti J, Eriksson JG, Auwerx J. PMID: 37118545.
      View in: PubMed   Mentions: 6  Translation:HumansAnimals
    21. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    22. Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. Eur Heart J. 2022 09 21; 43(36):3477-3489. Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, Kaur B, Feyen DAM, Diecke S, Snyder MP, Metallo CM, Mercola M, Karakikes I. PMID: 35728000; PMCID: PMC9794189.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. 1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells. J Lipid Res. 2022 10; 63(10):100281. Cordes T, Kuna RS, McGregor GH, Khare SV, Gengatharan J, Muthusamy T, Metallo CM. PMID: 36115594; PMCID: PMC9587408.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    24. Acetate reprograms gut microbiota during alcohol consumption. Nat Commun. 2022 08 08; 13(1):4630. Martino C, Zaramela LS, Gao B, Embree M, Tarasova J, Parker SJ, Wang Y, Chu H, Chen P, Lee KC, Galzerani DD, Gengatharan JM, Lekbua A, Neal M, Knight R, Tsukamoto H, Metallo CM, Schnabl B, Zengler K. PMID: 35941112; PMCID: PMC9359997.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    25. Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. Nat Metab. 2022 05; 4(5):524-533. He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. PMID: 35655024; PMCID: PMC9744384.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    26. The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. Cell Rep. 2022 05 10; 39(6):110792. Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo HH, Elemento O, Martin ML, Cordes T, Thompson TC, Metallo CM, Moscat J, Diaz-Meco MT. PMID: 35545049; PMCID: PMC9136538.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    27. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. Mol Metab. 2022 07; 61:101504. Casanova-Vallve N, Duglan D, Vaughan ME, Pariollaud M, Handzlik MK, Fan W, Yu RT, Liddle C, Downes M, Delezie J, Mello R, Chan AB, Westermark PO, Metallo CM, Evans RM, Lamia KA. PMID: 35470095; PMCID: PMC9079800.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    28. Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in PolgD257A mice. Sci Adv. 2021 Oct 15; 7(42):eabj4077. Lim EW, Handzlik MK, Trefts E, Gengatharan JM, Pondevida CM, Shaw RJ, Metallo CM. PMID: 34652935; PMCID: PMC8519573.
      View in: PubMed   Mentions: 3     Fields:    
    29. Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas. iScience. 2021 Oct 22; 24(10):103149. Parekh U, McDonald D, Dailamy A, Wu Y, Cordes T, Zhang K, Tipps A, Metallo C, Mali P. PMID: 34646987; PMCID: PMC8496177.
      View in: PubMed   Mentions: 1  
    30. NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions. Cell Rep. 2021 09 14; 36(11):109701. Kumar A, Cordes T, Thalacker-Mercer AE, Pajor AM, Murphy AN, Metallo CM. PMID: 34525352; PMCID: PMC8500708.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    31. Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response. Clin Cancer Res. 2022 01 01; 28(1):187-200. Yebra M, Bhargava S, Kumar A, Burgoyne AM, Tang CM, Yoon H, Banerjee S, Aguilera J, Cordes T, Sheth V, Noh S, Ustoy R, Li S, Advani SJ, Corless CL, Heinrich MC, Kurzrock R, Lippman SM, Fanta PT, Harismendy O, Metallo C, Sicklick JK. PMID: 34426440; PMCID: PMC8738129.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    32. PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. Dev Cell. 2021 06 07; 56(11):1661-1676.e10. Ravi A, Palamiuc L, Loughran RM, Triscott J, Arora GK, Kumar A, Tieu V, Pauli C, Reist M, Lew RJ, Houlihan SL, Fellmann C, Metallo C, Rubin MA, Emerling BM. PMID: 33984270; PMCID: PMC9012263.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children. J Pediatr Gastroenterol Nutr. 2021 04 01; 72(4):e90-e96. Sawh MC, Wallace M, Shapiro E, Goyal NP, Newton KP, Yu EL, Bross C, Durelle J, Knott C, Gangoiti JA, Barshop BA, Gengatharan JM, Meurs N, Schlein A, Middleton MS, Sirlin CB, Metallo CM, Schwimmer JB. PMID: 33399331; PMCID: PMC8842839.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    34. Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease. Nat Metab. 2021 03; 3(3):366-377. Eade K, Gantner ML, Hostyk JA, Nagasaki T, Giles S, Fallon R, Harkins-Perry S, Baldini M, Lim EW, Scheppke L, Dorrell MI, Cai C, Baugh EH, Wolock CJ, Wallace M, Berlow RB, Goldstein DB, Metallo CM, Friedlander M, Allikmets R. PMID: 33758422; PMCID: PMC8084205.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    35. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 2021 05 10; 39(5):678-693.e11. Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. PMID: 33740421; PMCID: PMC8119368.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    36. Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase. Metabolites. 2021 Feb 18; 11(2). Cordes T, Metallo CM. PMID: 33670656; PMCID: PMC7922098.
      View in: PubMed   Mentions: 18  
    37. Microbiota control of maternal behavior regulates early postnatal growth of offspring. Sci Adv. 2021 01; 7(5). Lee YM, Mu A, Wallace M, Gengatharan JM, Furst AJ, Bode L, Metallo CM, Ayres JS. PMID: 33514556; PMCID: PMC7846171.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Exploring the evolutionary roots and physiological function of itaconate. Curr Opin Biotechnol. 2021 04; 68:144-150. Cordes T, Metallo CM. PMID: 33296743.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    39. Tolerance to graded dosages of histidine supplementation in healthy human adults. Am J Clin Nutr. 2020 11 11; 112(5):1358-1367. Gheller ME, Vermeylen F, Handzlik MK, Gheller BJ, Bender E, Metallo C, Aydemir TB, Smriga M, Thalacker-Mercer AE. PMID: 32766885.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    40. TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell Metab. 2020 12 01; 32(6):1012-1027.e7. Huh JY, Reilly SM, Abu-Odeh M, Murphy AN, Mahata SK, Zhang J, Cho Y, Seo JB, Hung CW, Green CR, Metallo CM, Saltiel AR. PMID: 33152322; PMCID: PMC7710607.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    41. Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. Mol Metab. 2021 01; 43:101106. Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE. PMID: 33122122; PMCID: PMC7691553.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    42. A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells. J Am Chem Soc. 2020 10 21; 142(42):17887-17891. Rudd AK, Mittal N, Lim EW, Metallo CM, Devaraj NK. PMID: 33044062; PMCID: PMC8849011.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling. Cancer Metab. 2020; 8:22. Gaglio D, Bonanomi M, Valtorta S, Bharat R, Ripamonti M, Conte F, Fiscon G, Righi N, Napodano E, Papa F, Raccagni I, Parker SJ, Cifola I, Camboni T, Paci P, Colangelo AM, Vanoni M, Metallo CM, Moresco RM, Alberghina L. PMID: 33005401; PMCID: PMC7523077.
      View in: PubMed   Mentions: 7  
    44. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    45. Serine restriction alters sphingolipid diversity to constrain tumour growth. Nature. 2020 10; 586(7831):790-795. Muthusamy T, Cordes T, Handzlik MK, You L, Lim EW, Gengatharan J, Pinto AFM, Badur MG, Kolar MJ, Wallace M, Saghatelian A, Metallo CM. PMID: 32788725; PMCID: PMC7606299.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    46. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020 07 21; 32(3):107925. Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M. PMID: 32697997; PMCID: PMC7437654.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    47. Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus. Neurobiol Dis. 2020 09; 143:105018. Henke C, Töllner K, van Dijk RM, Miljanovic N, Cordes T, Twele F, Bröer S, Ziesak V, Rohde M, Hauck SM, Vogel C, Welzel L, Schumann T, Willmes DM, Kurzbach A, El-Agroudy NN, Bornstein SR, Schneider SA, Jordan J, Potschka H, Metallo CM, Köhling R, Birkenfeld AL, Löscher W. PMID: 32682952.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    48. Escher-Trace: a web application for pathway-based visualization of stable isotope tracing data. BMC Bioinformatics. 2020 Jul 10; 21(1):297. Kumar A, Mitchener J, King ZA, Metallo CM. PMID: 32650717; PMCID: PMC7350651.
      View in: PubMed   Mentions: 9     Fields:    
    49. Cryptochromes Suppress HIF1α in Muscles. iScience. 2020 Jul 24; 23(7):101338. Vaughan ME, Wallace M, Handzlik MK, Chan AB, Metallo CM, Lamia KA. PMID: 32683313; PMCID: PMC7371909.
      View in: PubMed   Mentions: 9  
    50. PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 08 10; 38(2):247-262.e11. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943; PMCID: PMC7423690.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    51. Sub-nanowatt microfluidic single-cell calorimetry. Nat Commun. 2020 06 12; 11(1):2982. Hong S, Dechaumphai E, Green CR, Lal R, Murphy AN, Metallo CM, Chen R. PMID: 32532969; PMCID: PMC7292832.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 04; 22(4):476-486. Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. PMID: 32231310; PMCID: PMC7194135.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    53. Tracing insights into de novo lipogenesis in liver and adipose tissues. Semin Cell Dev Biol. 2020 12; 108:65-71. Wallace M, Metallo CM. PMID: 32201132.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    54. Statins Limit Coenzyme Q Synthesis and Metabolically Synergize with MEK Inhibition in Pancreatic Tumors. Cancer Res. 2020 01 15; 80(2):151-152. Cordes T, Metallo CM. PMID: 31941676.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    55. Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells. Methods Mol Biol. 2020; 2088:51-71. Lim EW, Parker SJ, Metallo CM. PMID: 31893370.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    56. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. Mol Metab. 2020 02; 32:122-135. Cordes T, Lucas A, Divakaruni AS, Murphy AN, Cabrales P, Metallo CM. PMID: 32029222; PMCID: PMC6961711.
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    57. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019 12 19; 76(6):857-871.e9. Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, Wang M, Wu S, Dai Q, Vu H, Zacharias L, DeBerardinis R, Lim E, Metallo C, Boggon TJ, Lonial S, Lin R, Mao H, Pan Y, Shan C, Chen J. PMID: 31586547; PMCID: PMC6925637.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    58. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. N Engl J Med. 2019 10 10; 381(15):1422-1433. Gantner ML, Eade K, Wallace M, Handzlik MK, Fallon R, Trombley J, Bonelli R, Giles S, Harkins-Perry S, Heeren TFC, Sauer L, Ideguchi Y, Baldini M, Scheppke L, Dorrell MI, Kitano M, Hart BJ, Cai C, Nagasaki T, Badur MG, Okada M, Woods SM, Egan C, Gillies M, Guymer R, Eichler F, Bahlo M, Fruttiger M, Allikmets R, Bernstein PS, Metallo CM, Friedlander M. PMID: 31509666; PMCID: PMC7685488.
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    59. Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. Mol Cell. 2019 08 22; 75(4):807-822.e8. Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA. PMID: 31442424; PMCID: PMC7388077.
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    60. Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females. Cell Rep. 2019 05 28; 27(9):2772-2784.e6. Fernandez S, Viola JM, Torres A, Wallace M, Trefely S, Zhao S, Affronti HC, Gengatharan JM, Guertin DA, Snyder NW, Metallo CM, Wellen KE. PMID: 31141698; PMCID: PMC6608748.
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    61. ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. J Lipid Res. 2019 08; 60(8):1379-1395. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. PMID: 31092690; PMCID: PMC6672034.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    62. 3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress. Integr Biol (Camb). 2019 05 01; 11(5):221-234. Velez DO, Ranamukhaarachchi SK, Kumar A, Modi RN, Lim EW, Engler AJ, Metallo CM, Fraley SI. PMID: 31251330; PMCID: PMC6657753.
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    63. Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer Cell. 2019 03 18; 35(3):385-400.e9. Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT. PMID: 30827887; PMCID: PMC6424636.
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    64. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Rep. 2019 01 02; 26(1):192-208.e6. Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. PMID: 30605676; PMCID: PMC6344045.
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    65. Quantifying Intermediary Metabolism and Lipogenesis in Cultured Mammalian Cells Using Stable Isotope Tracing and Mass Spectrometry. Methods Mol Biol. 2019; 1978:219-241. Cordes T, Metallo CM. PMID: 31119666.
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    66. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875; PMCID: PMC6317899.
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    67. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30404018; PMCID: PMC7337229.
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    68. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Rep. 2018 10 23; 25(4):1018-1026.e4. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30355481; PMCID: PMC6613636.
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    69. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018 11; 14(11):1021-1031. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. PMID: 30327559; PMCID: PMC6245668.
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    70. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 09 20; 175(1):101-116.e25. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG. PMID: 30220459; PMCID: PMC6219629.
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    71. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. PMID: 30105314; PMCID: PMC6086353.
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    72. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037; PMCID: PMC6065037.
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    73. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Mol Cell. 2018 02 15; 69(4):699-708.e7. Zhao D, Badur MG, Luebeck J, Magaña JH, Birmingham A, Sasik R, Ahn CS, Ideker T, Metallo CM, Mali P. PMID: 29452643; PMCID: PMC5819357.
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    74. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Mol Cell. 2018 01 04; 69(1):87-99.e7. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S. PMID: 29249655; PMCID: PMC5777230.
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    75. Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease. Metab Eng. 2018 01; 45:95-108. Badur MG, Metallo CM. PMID: 29199104; PMCID: PMC5927620.
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    76. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 2018 01 09; 27(1):195-209.e6. Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. PMID: 29153407; PMCID: PMC5762420.
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    77. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell Metab. 2017 Dec 05; 26(6):817-829.e6. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. PMID: 28988820; PMCID: PMC5718961.
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    78. Engineering approaches to study cancer metabolism. Metab Eng. 2017 09; 43(Pt B):93. Metallo CM, Deberardinis RJ. PMID: 28918847.
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    79. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. Cancer Res. 2017 08 15; 77(16):4460-4471. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin ER, Seifert EL, Metallo CM, Brody JR, Winter JM. PMID: 28652247; PMCID: PMC5922269.
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    80. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. PMID: 28254829; PMCID: PMC5379957.
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    81. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017 09; 43(Pt B):208-217. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. PMID: 28034771; PMCID: PMC5484750.
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    82. CRY2 and FBXL3 Cooperatively Degrade c-MYC. Mol Cell. 2016 11 17; 64(4):774-789. Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM, Lamia KA. PMID: 27840026; PMCID: PMC5123859.
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    83. ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep. 2016 10 18; 17(4):1037-1052. Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE. PMID: 27760311; PMCID: PMC5175409.
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    84. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 10; 22(10):1108-1119. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. PMID: 27643638; PMCID: PMC5053891.
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    85. Tracing insights into human metabolism using chemical engineering approaches. Curr Opin Chem Eng. 2016 Nov; 14:72-81. Cordes T, Metallo CM. PMID: 28480159; PMCID: PMC5417699.
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    86. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 08 09; 16(6):1536-1547. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM. PMID: 27477285; PMCID: PMC4981511.
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    87. PGC1α drives a metabolic block on prostate cancer progression. Nat Cell Biol. 2016 05 27; 18(6):589-90. Wallace M, Metallo CM. PMID: 27230528.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    88. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 01; 291(27):14274-14284. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. PMID: 27189937; PMCID: PMC4933182.
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    89. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016 Apr 21; 7:11365. Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA. PMID: 27098609; PMCID: PMC4844681.
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    90. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature. 2016 Apr 14; 532(7598):255-8. Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, Schmidt S, Metallo CM, Dranka BP, Schwartz B, DeBerardinis RJ. PMID: 27049945; PMCID: PMC4860952.
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    91. Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics. Mol Cell. 2016 Jan 21; 61(2):185-6. Parker SJ, Metallo CM. PMID: 26799763.
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    92. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM. PMID: 26571352; PMCID: PMC4684771.
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    93. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. Nat Commun. 2015 Nov 02; 6:8784. Lussey-Lepoutre C, Hollinshead KE, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, Favier J, Tennant DA. PMID: 26522426; PMCID: PMC4632646.
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    94. Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance. Biotechnol J. 2015 Oct; 10(10):1600-11. Badur MG, Zhang H, Metallo CM. PMID: 26289220; PMCID: PMC4885641.
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    95. Metabolic consequences of oncogenic IDH mutations. Pharmacol Ther. 2015 Aug; 152:54-62. Parker SJ, Metallo CM. PMID: 25956465; PMCID: PMC4489982.
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    96. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Curr Opin Biotechnol. 2015 Aug; 34:189-201. Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. PMID: 25731751; PMCID: PMC4552607.
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    97. Mitochondria as biosynthetic factories for cancer proliferation. Cancer Metab. 2015; 3(1):1. Ahn CS, Metallo CM. PMID: 25621173; PMCID: PMC4305394.
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    98. Metabolic Analysis Using Stable Isotopes. Preface. Methods Enzymol. 2015; 561:xv-xvi. Metallo CM. PMID: 26358911.
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    99. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 06; 56(3):425-435. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM. PMID: 25458843; PMCID: PMC4267523.
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    100. Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell. 2014 Jul 14; 26(1):121-135. Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, Moscat J. PMID: 25002027; PMCID: PMC4101061.
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    101. Editorial overview: Systems biology: Advances in multi-scale systems biology applications. Curr Opin Biotechnol. 2014 Aug; 28:vi-viii. Sourjik V, Metallo C. PMID: 24996482.
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    102. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol Cell. 2014 Jul 17; 55(2):253-63. Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM. PMID: 24882210; PMCID: PMC4106038.
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    103. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM. PMID: 24755473; PMCID: PMC4885639.
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    104. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 2014 Feb; 3(1):42-54. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. PMID: 24567903; PMCID: PMC3929909.
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    105. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 2013 May 30; 497(7451):633-7. Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. PMID: 23665962; PMCID: PMC3810415.
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    106. NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data. Bioinformatics. 2013 May 01; 29(9):1226-8. Hiller K, Wegner A, Weindl D, Cordes T, Metallo CM, Kelleher JK, Stephanopoulos G. PMID: 23479350; PMCID: PMC3634188.
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    107. Understanding metabolic regulation and its influence on cell physiology. Mol Cell. 2013 Feb 07; 49(3):388-98. Metallo CM, Vander Heiden MG. PMID: 23395269; PMCID: PMC3569837.
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    108. Profiling metabolic networks to study cancer metabolism. Curr Opin Biotechnol. 2013 Feb; 24(1):60-8. Hiller K, Metallo CM. PMID: 23206561.
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    109. Expanding the reach of cancer metabolomics. Cancer Prev Res (Phila). 2012 Dec; 5(12):1337-40. Metallo CM. PMID: 23151806.
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    110. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct; 8(10):839-47. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. PMID: 22922757; PMCID: PMC3711671.
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    111. Exploring metabolic pathways that contribute to the stem cell phenotype. Biochim Biophys Acta. 2013 Feb; 1830(2):2361-9. Vacanti NM, Metallo CM. PMID: 22917650.
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    112. Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol. 2011; 76:325-34. Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. PMID: 22262476.
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    113. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Metab Eng. 2012 Mar; 14(2):162-71. Walther JL, Metallo CM, Zhang J, Stephanopoulos G. PMID: 22198197; PMCID: PMC3586220.
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    114. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2011 Nov 20; 481(7381):380-4. Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. PMID: 22101433; PMCID: PMC3710581.
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    115. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol. 2011 Aug 16; 7:523. Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. PMID: 21847114; PMCID: PMC3202795.
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    116. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011 Aug 15; 25(16):1716-33. Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. PMID: 21852536; PMCID: PMC3165936.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    117. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31; 43(9):869-74. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. PMID: 21804546; PMCID: PMC3677549.
      View in: PubMed   Mentions: 582     Fields:    Translation:HumansCells
    118. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics. Curr Pharm Biotechnol. 2011 Jul; 12(7):1075-86. Hiller K, Metallo C, Stephanopoulos G. PMID: 21466455.
      View in: PubMed   Mentions: 24     Fields:    
    119. Metabolism strikes back: metabolic flux regulates cell signaling. Genes Dev. 2010 Dec 15; 24(24):2717-22. Metallo CM, Vander Heiden MG. PMID: 21159812; PMCID: PMC3003187.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    120. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. Anal Chem. 2010 Aug 01; 82(15):6621-8. Hiller K, Metallo CM, Kelleher JK, Stephanopoulos G. PMID: 20608743.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    121. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. Tissue Eng Part A. 2010 Jan; 16(1):213-23. Metallo CM, Azarin SM, Moses LE, Ji L, de Pablo JJ, Palecek SP. PMID: 19686061; PMCID: PMC2810995.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    122. Directed differentiation of human embryonic stem cells to epidermal progenitors. Methods Mol Biol. 2010; 585:83-92. Metallo CM, Ji L, de Pablo JJ, Palecek SP. PMID: 19907998; PMCID: PMC2821706.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    123. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol. 2009 Nov; 144(3):167-74. Metallo CM, Walther JL, Stephanopoulos G. PMID: 19622376; PMCID: PMC3026314.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    124. The response of human embryonic stem cell-derived endothelial cells to shear stress. Biotechnol Bioeng. 2008 Jul 01; 100(4):830-7. Metallo CM, Vodyanik MA, de Pablo JJ, Slukvin II, Palecek SP. PMID: 18306423.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    125. Engineering tissue from human embryonic stem cells. J Cell Mol Med. 2008 Jun; 12(3):709-29. Metallo CM, Azarin SM, Ji L, de Pablo JJ, Palecek SP. PMID: 18194458; PMCID: PMC2670852.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    126. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells. 2008 Feb; 26(2):372-80. Metallo CM, Ji L, de Pablo JJ, Palecek SP. PMID: 17962700.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    127. Engineering the stem cell microenvironment. Biotechnol Prog. 2007 Jan-Feb; 23(1):18-23. Metallo CM, Mohr JC, Detzel CJ, de Pablo JJ, Van Wie BJ, Palecek SP. PMID: 17269664.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    128. Large-scale propagation of a replication-defective adenovirus vector in stirred-tank bioreactor PER.C6 cell culture under sparging conditions. Biotechnol Bioeng. 2003 Jul 05; 83(1):45-52. Xie L, Metallo C, Warren J, Pilbrough W, Peltier J, Zhong T, Pikus L, Yancy A, Leung J, Aunins JG, Zhou W. PMID: 12740932.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
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