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    Christian Metallo

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-534-8209
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Role of p62 in metabolic reprograming of the tumor stroma in prostate cancer
      NIH/NCI R01CA218254Aug 1, 2017 - Jul 31, 2022
      Role: Co-Principal Investigator
      Exploiting Metabloic Defects in Tumors with Mutant IDH1 and IDH2
      NIH/NCI R01CA188652Jul 1, 2014 - Jun 30, 2019
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin ER, Seifert EL, Metallo C, Brody JR, Winter JM. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. Cancer Res. 2017 Aug 15; 77(16):4460-4471. PMID: 28652247.
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      2. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo C, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 Apr 03; 216(4):1091-1105. PMID: 28254829.
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      3. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo C. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2016 Dec 26. PMID: 28034771.
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      4. Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo C, Lamia KA. CRY2 and FBXL3 Cooperatively Degrade c-MYC. Mol Cell. 2016 Nov 17; 64(4):774-789. PMID: 27840026.
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      5. Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo C, Snyder NW, Andrews AJ, Wellen KE. ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep. 2016 Oct 18; 17(4):1037-1052. PMID: 27760311.
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      6. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo C, Shaw RJ. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct; 22(10):1108-1119. PMID: 27643638.
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      7. Cordes T, Metallo C. Tracing insights into human metabolism using chemical engineering approaches. Curr Opin Chem Eng. 2016 Nov; 14:72-81. PMID: 28480159.
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      8. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo C. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 Aug 9; 16(6):1536-47. PMID: 27477285.
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      9. Wallace M, Metallo C. PGC1a drives a metabolic block on prostate cancer progression. Nat Cell Biol. 2016 May 27; 18(6):589-90. PMID: 27230528.
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      10. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo C. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 1; 291(27):14274-84. PMID: 27189937.
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      11. Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo C, Guertin DA. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016; 7:11365. PMID: 27098609.
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      12. Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, Schmidt S, Metallo C, Dranka BP, Schwartz B, DeBerardinis RJ. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature. 2016 Apr 14; 532(7598):255-8. PMID: 27049945.
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      13. Parker SJ, Metallo C. Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics. Mol Cell. 2016 Jan 21; 61(2):185-6. PMID: 26799763.
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      14. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo C. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. PMID: 26571352.
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      15. Lussey-Lepoutre C, Hollinshead KE, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, Favier J, Tennant DA. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. Nat Commun. 2015; 6:8784. PMID: 26522426.
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      16. Badur MG, Zhang H, Metallo C. Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance. Biotechnol J. 2015 Oct; 10(10):1600-11. PMID: 26289220.
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      17. Parker SJ, Metallo C. Metabolic consequences of oncogenic IDH mutations. Pharmacol Ther. 2015 Aug; 152:54-62. PMID: 25956465.
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      18. Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo C, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Curr Opin Biotechnol. 2015 Aug; 34:189-201. PMID: 25731751.
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      19. Ahn CS, Metallo C. Mitochondria as biosynthetic factories for cancer proliferation. Cancer Metab. 2015; 3(1):1. PMID: 25621173.
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      20. Metallo C. Preface. Methods Enzymol. 2015; 561:xv-xvi. PMID: 26358911.
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      21. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo C. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 6; 56(3):425-35. PMID: 25458843.
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      22. Sourjik V, Metallo C. Editorial overview: Systems biology: Advances in multi-scale systems biology applications. Curr Opin Biotechnol. 2014 Aug; 28:vi-viii. PMID: 24996482.
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      23. Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo C. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of Mammalian cells. Mol Cell. 2014 Jul 17; 55(2):253-63. PMID: 24882210.
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      24. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo C. IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. PMID: 24755473.
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      25. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo C, Haddad GG. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 2014 Feb; 3(1):42-54. PMID: 24567903.
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      26. Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo C, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 2013 May 30; 497(7451):633-7. PMID: 23665962.
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      27. Hiller K, Wegner A, Weindl D, Cordes T, Metallo C, Kelleher JK, Stephanopoulos G. NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data. Bioinformatics. 2013 May 1; 29(9):1226-8. PMID: 23479350.
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      28. Metallo C, Vander Heiden MG. Understanding metabolic regulation and its influence on cell physiology. Mol Cell. 2013 Feb 7; 49(3):388-98. PMID: 23395269.
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      29. Hiller K, Metallo C. Profiling metabolic networks to study cancer metabolism. Curr Opin Biotechnol. 2013 Feb; 24(1):60-8. PMID: 23206561.
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      30. Metallo C. Expanding the reach of cancer metabolomics. Cancer Prev Res (Phila). 2012 Dec; 5(12):1337-40. PMID: 23151806.
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      31. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo C, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct; 8(10):839-47. PMID: 22922757.
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      32. Vacanti NM, Metallo C. Exploring metabolic pathways that contribute to the stem cell phenotype. Biochim Biophys Acta. 2013 Feb; 1830(2):2361-9. PMID: 22917650.
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      33. Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo C, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol. 2011; 76:325-34. PMID: 22262476.
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      34. Walther JL, Metallo C, Zhang J, Stephanopoulos G. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Metab Eng. 2012 Mar; 14(2):162-71. PMID: 22198197.
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      35. Metallo C, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2012 Jan 19; 481(7381):380-4. PMID: 22101433.
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      36. Gaglio D, Metallo C, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol. 2011; 7:523. PMID: 21847114.
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      37. Grassian AR, Metallo C, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011 Aug 15; 25(16):1716-33. PMID: 21852536.
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      38. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo C, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Sep; 43(9):869-74. PMID: 21804546.
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      39. Hiller K, Metallo C, Stephanopoulos G. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics. Curr Pharm Biotechnol. 2011 Jul; 12(7):1075-86. PMID: 21466455.
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      40. Metallo C, Vander Heiden MG. Metabolism strikes back: metabolic flux regulates cell signaling. Genes Dev. 2010 Dec 15; 24(24):2717-22. PMID: 21159812.
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      41. Hiller K, Metallo C, Kelleher JK, Stephanopoulos G. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. Anal Chem. 2010 Aug 1; 82(15):6621-8. PMID: 20608743.
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      42. Metallo C, Ji L, de Pablo JJ, Palecek SP. Directed differentiation of human embryonic stem cells to epidermal progenitors. Methods Mol Biol. 2010; 585:83-92. PMID: 19907998.
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      43. Metallo C, Azarin SM, Moses LE, Ji L, de Pablo JJ, Palecek SP. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. Tissue Eng Part A. 2010 Jan; 16(1):213-23. PMID: 19686061.
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      44. Metallo C, Walther JL, Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol. 2009 Nov; 144(3):167-74. PMID: 19622376.
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      45. Metallo C, Vodyanik MA, de Pablo JJ, Slukvin II, Palecek SP. The response of human embryonic stem cell-derived endothelial cells to shear stress. Biotechnol Bioeng. 2008 Jul 1; 100(4):830-7. PMID: 18306423.
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      46. Metallo C, Azarin SM, Ji L, de Pablo JJ, Palecek SP. Engineering tissue from human embryonic stem cells. J Cell Mol Med. 2008 Jun; 12(3):709-29. PMID: 18194458.
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      47. Metallo C, Ji L, de Pablo JJ, Palecek SP. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells. 2008 Feb; 26(2):372-80. PMID: 17962700.
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      48. Metallo C, Mohr JC, Detzel CJ, de Pablo JJ, Van Wie BJ, Palecek SP. Engineering the stem cell microenvironment. Biotechnol Prog. 2007 Jan-Feb; 23(1):18-23. PMID: 17269664.
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      49. Xie L, Metallo C, Warren J, Pilbrough W, Peltier J, Zhong T, Pikus L, Yancy A, Leung J, Aunins JG, Zhou W. Large-scale propagation of a replication-defective adenovirus vector in stirred-tank bioreactor PER.C6 cell culture under sparging conditions. Biotechnol Bioeng. 2003 Jul 5; 83(1):45-52. PMID: 12740932.
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      50. Xie L, Pilbrough W, Metallo C, Zhong T, Pikus L, Leung J, Aunins JG, Zhou W. Serum-free suspension cultivation of PER.C6(R) cells and recombinant adenovirus production under different pH conditions. Biotechnol Bioeng. 2002 Dec 5; 80(5):569-79. PMID: 12355468.
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