Sven Heinz

Title(s)Assistant Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Regensburg, Regensburg, GermanyDiplom09/1996Chemistry
    University of Regensburg, Regensburg, GermanyPh.D.08/2002Chemistry

    Collapse Research 
    Collapse Research Activities and Funding
    How transcription disrupts genome 3D organization
    NIH R01GM129523Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Molecular and genetic analysis of DP103
    NIH F32HL083752Dec 1, 2006 - Nov 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Nat Commun. 2022 Dec 02; 13(1):7444. Cattaneo P, Hayes MGB, Baumgarten N, Hecker D, Peruzzo S, Aslan GS, Kunderfranco P, Larcher V, Zhang L, Contu R, Fonseca G, Spinozzi S, Chen J, Condorelli G, Dimmeler S, Schulz MH, Heinz S, Guimarães-Camboa N, Evans SM. PMID: 36460641.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. MEPP: more transparent motif enrichment by profiling positional correlations. NAR Genom Bioinform. 2022 Dec; 4(4):lqac075. Delos Santos NP, Duttke S, Heinz S, Benner C. PMID: 36267125; PMCID: PMC9575187.
      View in: PubMed   Mentions:
    3. Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches. STAR Protoc. 2021 03 19; 2(1):100363. Troutman TD, Bennett H, Sakai M, Seidman JS, Heinz S, Glass CK. PMID: 33748781; PMCID: PMC7960533.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells. STAR Protoc. 2021 03 19; 2(1):100358. Texari L, Spann NJ, Troutman TD, Sakai M, Seidman JS, Heinz S. PMID: 33718886; PMCID: PMC7921621.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function. Diabetes. 2021 03; 70(3):665-679. Cividini F, Scott BT, Suarez J, Casteel DE, Heinz S, Dai A, Diemer T, Suarez JA, Benner CW, Ghassemian M, Dillmann WH. PMID: 33303689; PMCID: PMC7897348.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. ARTDeco: automatic readthrough transcription detection. BMC Bioinformatics. 2020 May 26; 21(1):214. Roth SJ, Heinz S, Benner C. PMID: 32456667; PMCID: PMC7249449.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020 05; 158(6):1728-1744.e14. Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. PMID: 31982409; PMCID: PMC7252905.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    8. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    9. Identification and dynamic quantification of regulatory elements using total RNA. Genome Res. 2019 11; 29(11):1836-1846. Duttke SH, Chang MW, Heinz S, Benner C. PMID: 31649059; PMCID: PMC6836739.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    10. Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity. 2019 10 15; 51(4):655-670.e8. Sakai M, Troutman TD, Seidman JS, Ouyang Z, Spann NJ, Abe Y, Ego KM, Bruni CM, Deng Z, Schlachetzki JCM, Nott A, Bennett H, Chang J, Vu BT, Pasillas MP, Link VM, Texari L, Heinz S, Thompson BM, McDonald JG, Geissmann F, Glass CK. PMID: 31587991; PMCID: PMC6800814.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    11. Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers. Cell. 2019 10 03; 179(2):373-391.e27. Brigidi GS, Hayes MGB, Delos Santos NP, Hartzell AL, Texari L, Lin PA, Bartlett A, Ecker JR, Benner C, Heinz S, Bloodgood BL. PMID: 31585079; PMCID: PMC6800120.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9172-E9181. Carlin AF, Vizcarra EA, Branche E, Viramontes KM, Suarez-Amaran L, Ley K, Heinz S, Benner C, Shresta S, Glass CK. PMID: 30206152; PMCID: PMC6166801.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    13. Transcription Elongation Can Affect Genome 3D Structure. Cell. 2018 09 06; 174(6):1522-1536.e22. Heinz S, Texari L, Hayes MGB, Urbanowski M, Chang MW, Givarkes N, Rialdi A, White KM, Albrecht RA, Pache L, Marazzi I, García-Sastre A, Shaw ML, Benner C. PMID: 30146161; PMCID: PMC6130916.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    14. Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer. Mol Cell. 2018 06 07; 70(5):842-853.e7. Zhu Q, Hoong N, Aslanian A, Hara T, Benner C, Heinz S, Miga KH, Ke E, Verma S, Soroczynski J, Yates JR, Hunter T, Verma IM. PMID: 29861157; PMCID: PMC6545586.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    15. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T. PMID: 28287406; PMCID: PMC5373891.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    16. Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 2016 10 20; 538(7625):336-343. Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS. PMID: 27762356; PMCID: PMC5313049.
      View in: PubMed   Mentions: 364     Fields:    Translation:AnimalsCells
    17. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016 May 27; 352(6289):aad7993. Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. PMID: 27127234; PMCID: PMC5193222.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    18. Perspectives on Unidirectional versus Divergent Transcription. Mol Cell. 2015 Nov 05; 60(3):348-9. Duttke SH, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. PMID: 26545075; PMCID: PMC4643650.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    19. Exploiting genomics and natural genetic variation to decode macrophage enhancers. Trends Immunol. 2015 Sep; 36(9):507-18. Romanoski CE, Link VM, Heinz S, Glass CK. PMID: 26298065; PMCID: PMC4548828.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nat Immunol. 2015 May; 16(5):485-94. Miller MS, Rialdi A, Ho JS, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre AM, Mitsopoulos P, Madrenas J, Heinz S, Benner C, Young JA, Feagins AR, Basler CF, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I. PMID: 25822250; PMCID: PMC4406851.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    21. The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol. 2015 Mar; 16(3):144-54. Heinz S, Romanoski CE, Benner C, Glass CK. PMID: 25650801; PMCID: PMC4517609.
      View in: PubMed   Mentions: 466     Fields:    Translation:HumansAnimalsCells
    22. Human promoters are intrinsically directional. Mol Cell. 2015 Feb 19; 57(4):674-684. Duttke SHC, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. PMID: 25639469; PMCID: PMC4336624.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    23. Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. Nucleic Acids Res. 2014 Nov 10; 42(20):12570-84. Kaikkonen MU, Niskanen H, Romanoski CE, Kansanen E, Kivelä AM, Laitalainen J, Heinz S, Benner C, Glass CK, Ylä-Herttuala S. PMID: 25352550; PMCID: PMC4227755.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. Effect of natural genetic variation on enhancer selection and function. Nature. 2013 Nov 28; 503(7477):487-92. Heinz S, Romanoski CE, Benner C, Allison KA, Kaikkonen MU, Orozco LD, Glass CK. PMID: 24121437; PMCID: PMC3994126.
      View in: PubMed   Mentions: 190     Fields:    Translation:AnimalsCells
    25. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol Cell. 2013 Aug 08; 51(3):310-25. Kaikkonen MU, Spann NJ, Heinz S, Romanoski CE, Allison KA, Stender JD, Chun HB, Tough DF, Prinjha RK, Benner C, Glass CK. PMID: 23932714; PMCID: PMC3779836.
      View in: PubMed   Mentions: 356     Fields:    Translation:AnimalsCells
    26. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27; 498(7455):511-5. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK. PMID: 23728303; PMCID: PMC3839578.
      View in: PubMed   Mentions: 309     Fields:    Translation:AnimalsCells
    27. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol. 2012 Dec; 13(12):1196-204. Lin YC, Benner C, Mansson R, Heinz S, Miyazaki K, Miyazaki M, Chandra V, Bossen C, Glass CK, Murre C. PMID: 23064439; PMCID: PMC3501570.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    28. Roles of lineage-determining transcription factors in establishing open chromatin: lessons from high-throughput studies. Curr Top Microbiol Immunol. 2012; 356:1-15. Heinz S, Glass CK. PMID: 21744305.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    29. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec; 7(12):e1002401. Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. PMID: 22174696; PMCID: PMC3234212.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    30. Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood. 2011 Aug 25; 118(8):2275-84. Ghani S, Riemke P, Schönheit J, Lenze D, Stumm J, Hoogenkamp M, Lagendijk A, Heinz S, Bonifer C, Bakkers J, Abdelilah-Seyfried S, Hummel M, Rosenbauer F. PMID: 21730352.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    31. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol. 2011 Mar; 25(3):529-45. Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass CK, Evans RM, Witztum JL. PMID: 21273443; PMCID: PMC3045740.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. Blood. 2011 Mar 10; 117(10):2827-38. Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosammam AM, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F. PMID: 21239694; PMCID: PMC3062295.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    33. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass CK. PMID: 21135125; PMCID: PMC3028656.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    34. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010 Dec 15; 29(24):4223-36. Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky JM. PMID: 21045807; PMCID: PMC3018786.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    35. Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol. 2010; 11(6):R63. Klug M, Heinz S, Gebhard C, Schwarzfischer L, Krause SW, Andreesen R, Rehli M. PMID: 20565882; PMCID: PMC2911111.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    36. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. PMID: 20543837; PMCID: PMC2896911.
      View in: PubMed   Mentions: 291     Fields:    Translation:AnimalsCells
    37. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28; 38(4):576-89. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. PMID: 20513432; PMCID: PMC2898526.
      View in: PubMed   Mentions: 5488     Fields:    Translation:AnimalsCells
    38. Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter. BMC Mol Biol. 2006 Nov 29; 7:45. Liddiard K, Welch JS, Lozach J, Heinz S, Glass CK, Greaves DR. PMID: 17134490; PMCID: PMC1698493.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    39. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. J Immunol. 2005 Jun 01; 174(11):7111-22. Rehli M, Sulzbacher S, Pape S, Ravasi T, Wells CA, Heinz S, Söllner L, El Chartouni C, Krause SW, Steingrimsson E, Hume DA, Andreesen R. PMID: 15908341.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    40. Species-specific regulation of Toll-like receptor 3 genes in men and mice. J Biol Chem. 2003 Jun 13; 278(24):21502-9. Heinz S, Haehnel V, Karaghiosoff M, Schwarzfischer L, Müller M, Krause SW, Rehli M. PMID: 12672806.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    41. Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. Genomics. 2002 Apr; 79(4):608-15. Heinz S, Krause SW, Gabrielli F, Wagner HM, Andreesen R, Rehli M. PMID: 11944995.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84. Biochem J. 2000 Mar 15; 346 Pt 3:729-36. Krause SW, Rehli M, Heinz S, Ebner R, Andreesen R. PMID: 10698700; PMCID: PMC1220906.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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