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Sylvia Evans

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0613C
La Jolla CA 92093
Phone858-822-2452
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of British Colombia

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Developmental Regulatory Genomics of Human Cardiovascular Lineages
    NIH/NHLBI UM1HL128773Aug 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Luma in Cardiac Function and Disease
    NIH/NHLBI R01HL123626Aug 1, 2014 - Jul 31, 2018
    Role: Co-Principal Investigator
    The Role of Dot1L in developing and postnatal heart
    NIH/NHLBI R01HL123747Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Endocardial Pathways Regulated by Tbx20
    NIH/NHLBI R01HL119967Dec 15, 2013 - Nov 30, 2017
    Role: Principal Investigator
    REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
    NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Approaches to Cardiac Regeneration
    NIH/NHLBI DP1HL117649Sep 30, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Approaches to Cardiac Regeneration
    NIH DP1OD006428Sep 30, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Mechanisms of Islet1 Action in Heart Development
    NIH/NHLBI R01HL074066Jul 1, 2003 - Mar 31, 2012
    Role: Principal Investigator
    The Role of Tbox20 in Cardiac Development &Adult Heart
    NIH/NHLBI R01HL070867Jul 1, 2002 - Apr 30, 2011
    Role: Principal Investigator
    Temporal and Spatial BMP Signalling and Cardiogenesis
    NIH/NHLBI R01HL066276Sep 1, 2001 - Aug 31, 2005
    Role: Principal Investigator
    TINMAN HOMOLOGUES AND CARDIAC DEVELOPMENT
    NIH/NHLBI R01HL056892Jan 15, 1998 - Dec 31, 2001
    Role: Principal Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    GENE EXPRESSION IN NORMAL/ABNORMAL CARDIAC DEVELOPMENT
    NIH/NHLBI R29HL046761Apr 1, 1992 - Mar 31, 1997
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stroud MJ, Fang X, Zhang J, Guimarães-Camboa N, Veevers J, Dalton ND, Gu Y, Bradford WH, Peterson KL, Evans S, Gerace L, Chen J. Luma is not essential for murine cardiac development and function. Cardiovasc Res. 2018 Mar 01; 114(3):378-388. PMID: 29040414.
      View in: PubMed
    2. Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans S, Jiang C, Liang X, Sun Y. Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14; 9(2):247. PMID: 29445148.
      View in: PubMed
    3. Moore-Morris T, Cattaneo P, Guimarães-Camboa N, Bogomolovas J, Cedenilla M, Banerjee I, Ricote M, Kisseleva T, Zhang L, Gu Y, Dalton ND, Peterson KL, Chen J, Pucéat M, Evans S. Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages. Circ Res. 2018 Feb 16; 122(4):583-590. PMID: 29269349.
      View in: PubMed
    4. Schafer S, Viswanathan S, Widjaja AA, Lim WW, Moreno-Moral A, DeLaughter DM, Ng B, Patone G, Chow K, Khin E, Tan J, Chothani SP, Ye L, Rackham OJL, Ko NSJ, Sahib NE, Pua CJ, Zhen NTG, Xie C, Wang M, Maatz H, Lim S, Saar K, Blachut S, Petretto E, Schmidt S, Putoczki T, Guimarães-Camboa N, Wakimoto H, van Heesch S, Sigmundsson K, Lim SL, Soon JL, Chao VTT, Chua YL, Tan TE, Evans S, Loh YJ, Jamal MH, Ong KK, Chua KC, Ong BH, Chakaramakkil MJ, Seidman JG, Seidman CE, Hubner N, Sin KYK, Cook SA. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 12 07; 552(7683):110-115. PMID: 29160304.
      View in: PubMed
    5. Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans S, Fowler VM, Chen J. HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 Nov 07; 114(45):11956-11961. PMID: 29078393.
      View in: PubMed
    6. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans S, Chen J. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200. PMID: 28737513.
      View in: PubMed
    7. van Vliet PP, Lin L, Boogerd CJ, Martin JF, Andelfinger G, Grossfeld PD, Evans S. Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Dev Biol. 2017 09 01; 429(1):249-259. PMID: 28669819.
      View in: PubMed
    8. Guimarães-Camboa N, Evans S. Are Perivascular Adipocyte Progenitors Mural Cells or Adventitial Fibroblasts? Cell Stem Cell. 2017 05 04; 20(5):587-589. PMID: 28475883.
      View in: PubMed
    9. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans S, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 04 11; 8(4):1086-1100. PMID: 28410642.
      View in: PubMed
    10. Guimarães-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans S. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 03 02; 20(3):345-359.e5. PMID: 28111199.
      View in: PubMed
    11. Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017 Feb 01; 127(2):569-582. PMID: 28067668.
      View in: PubMed
    12. Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans S, Rao A. Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):E8267-E8276. PMID: 27930333.
      View in: PubMed
    13. Guimarães-Camboa N, Evans S. Redox Paradox: Can Hypoxia Heal Ischemic Hearts? Dev Cell. 2016 11 21; 39(4):392-394. PMID: 27875683.
      View in: PubMed
    14. Liang X, Evans S, Sun Y. Development of the cardiac pacemaker. Cell Mol Life Sci. 2017 04; 74(7):1247-1259. PMID: 27770149.
      View in: PubMed
    15. Boogerd CJ, Aneas I, Sakabe N, Dirschinger RJ, Cheng QJ, Zhou B, Chen J, Nobrega MA, Evans S. Probing chromatin landscape reveals roles of endocardial TBX20 in septation. J Clin Invest. 2016 Aug 01; 126(8):3023-35. PMID: 27348591.
      View in: PubMed
    16. Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans S, Chai G, Goffinet AM, Qu Y, Zhou L. Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons. Cereb Cortex. 2016 07; 26(7):3323-34. PMID: 27170656; PMCID: PMC4898681.
    17. Bolt CC, Negi S, Guimarães-Camboa N, Zhang H, Troy JM, Lu X, Kispert A, Evans S, Stubbs L. Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS One. 2016; 11(4):e0154413. PMID: 27120339; PMCID: PMC4847854.
    18. Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans S, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016 Aug 01; 111(3):274-86. PMID: 27097650; PMCID: PMC4957488 [Available on 08/01/17].
    19. Hirai M, Chen J, Evans S. Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. Genesis. 2016 05; 54(5):286-96. PMID: 26990996; PMCID: PMC5021172.
    20. Hirai M, Cattaneo P, Chen J, Evans S. Revisiting Preadolescent Cardiomyocyte Proliferation in Mice. Circ Res. 2016 Mar 18; 118(6):916-919. PMID: 26987912; PMCID: PMC4800493 [Available on 03/18/17].
    21. Liu Q, Zhang H, Tian X, He L, Huang X, Tan Z, Yan Y, Evans S, Wythe JD, Zhou B. Smooth muscle origin of postnatal 2nd CVP is pre-determined in early embryo. Biochem Biophys Res Commun. 2016 Mar 18; 471(4):430-6. PMID: 26902114.
      View in: PubMed
    22. Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans S, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK. Sall1 transiently marks undifferentiated heart precursors and regulates their fate. J Mol Cell Cardiol. 2016 Mar; 92:158-62. PMID: 26876450; PMCID: PMC4789172.
    23. Boogerd CJ, Evans S. TBX5 and NuRD Divide the Heart. Dev Cell. 2016 Feb 08; 36(3):242-4. PMID: 26859347.
      View in: PubMed
    24. Moore-Morris T, Cattaneo P, Puceat M, Evans S. Origins of cardiac fibroblasts. J Mol Cell Cardiol. 2016 Feb; 91:1-5. PMID: 26748307; PMCID: PMC4764439 [Available on 02/01/17].
    25. Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans S, Fuchs E, Cleveland DW. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6321-30. PMID: 26578792; PMCID: PMC4655534.
    26. Hirai M, Chen J, Evans S. Tissue-Specific Cell Cycle Indicator Reveals Unexpected Findings for Cardiac Myocyte Proliferation. Circ Res. 2016 Jan 08; 118(1):20-8. PMID: 26472817.
      View in: PubMed
    27. Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans S, Braun T, Soler E, Grosveld F, Dobreva G. The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell. 2015 Sep 03; 17(3):287-99. PMID: 26321200.
      View in: PubMed
    28. Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans S. Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest. 2015 Aug 03; 125(8):3256-68. PMID: 26193633; PMCID: PMC4563735.
    29. Moore-Morris T, Guimarães-Camboa N, Yutzey KE, Pucéat M, Evans S. Cardiac fibroblasts: from development to heart failure. J Mol Med (Berl). 2015 Aug; 93(8):823-30. PMID: 26169532; PMCID: PMC4512919.
    30. Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans S, Zambon AC. HIF1a Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08; 33(5):507-21. PMID: 26028220; PMCID: PMC4509618.
    31. Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans S, Cheng H, Chen J. Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 05; 4(5). PMID: 25944877; PMCID: PMC4599425.
    32. Abboud N, Moore-Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi MG, Stefanovic S, Guénantin AC, Evans S, Pucéat M. A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015 Apr 08; 6:6749. PMID: 25851587.
      View in: PubMed
    33. Sinha T, Lin L, Li D, Davis J, Evans S, Wynshaw-Boris A, Wang J. Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development. Dev Biol. 2015 Feb 15; 398(2):177-92. PMID: 25448697; PMCID: PMC4317568.
    34. Moore-Morris T, Tallquist MD, Evans S. Sorting out where fibroblasts come from. Circ Res. 2014 Sep 12; 115(7):602-4. PMID: 25214570; PMCID: PMC4176694.
    35. Ouyang K, Leandro Gomez-Amaro R, Stachura DL, Tang H, Peng X, Fang X, Traver D, Evans S, Chen J. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12; 5:4814. PMID: 25215520.
      View in: PubMed
    36. Liang X, Evans S, Sun Y. Insights into cardiac conduction system formation provided by HCN4 expression. Trends Cardiovasc Med. 2015 Jan; 25(1):1-9. PMID: 25442735.
      View in: PubMed
    37. Chen J, Fu R, Cui Y, Pan J, Li Y, Zhang X, Evans S, Cui S, Liu J. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice. Mol Endocrinol. 2014 Aug; 28(8):1276-90. PMID: 24956377.
      View in: PubMed
    38. Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans S. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34. PMID: 24937432; PMCID: PMC4071409.
    39. Hiriart E, van Vliet P, Dirschinger RJ, Evans S, Puceat M. Cell labeling and injection in developing embryonic mouse hearts. J Vis Exp. 2014 Apr 17; (86). PMID: 24797676; PMCID: PMC4172201.
    40. Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, Zhang X, Evans S, Cui Y, Cui S. LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. BMC Biol. 2014 Mar 27; 12:25. PMID: 24674670; PMCID: PMC4021819.
    41. Banerjee I, Zhang J, Moore-Morris T, Pfeiffer E, Buchholz KS, Liu A, Ouyang K, Stroud MJ, Gerace L, Evans S, McCulloch A, Chen J. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet. 2014 Feb; 10(2):e1004114. PMID: 24586179; PMCID: PMC3930490.
    42. Akiyama R, Kawakami H, Taketo MM, Evans S, Wada N, Petryk A, Kawakami Y. Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the ß-catenin pathway. Dev Biol. 2014 Mar 01; 387(1):37-48. PMID: 24424161; PMCID: PMC3947553.
    43. Moore-Morris T, Pucéat M, Evans S. Targeting cardiac fibroblasts: the pressure is on. Cell Cycle. 2014; 13(17):2647-8. PMID: 25486346; PMCID: PMC4615117.
    44. Lu KM, Evans S, Hirano S, Liu FC. Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):E168-77. PMID: 24351932; PMCID: PMC3890800.
    45. Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans S, Sun Y, Chen J, Liang X. Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013 Oct 16; 11:107. PMID: 24131868.
      View in: PubMed
    46. Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans S, Omens JH, Peterson KL, McCulloch AD, Sheikh F. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 01; 23(5):1134-50. PMID: 24108106; PMCID: PMC3919010.
    47. Zhuang S, Zhang Q, Zhuang T, Evans S, Liang X, Sun Y. Expression of Isl1 during mouse development. Gene Expr Patterns. 2013 Dec; 13(8):407-12. PMID: 23906961; PMCID: PMC4134129.
    48. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans S, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92. PMID: 23873040.
      View in: PubMed
    49. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans S, Gittenberger-de Groot AC, Red-Horse K, Zhou B. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res. 2013 Sep; 23(9):1075-90. PMID: 23797856; PMCID: PMC3760626.
    50. Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans S. HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013 Aug 02; 113(4):399-407. PMID: 23743334; PMCID: PMC4017870.
    51. Huber K, Narasimhan P, Shtukmaster S, Pfeifer D, Evans S, Sun Y. The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells. Dev Biol. 2013 Aug 15; 380(2):286-98. PMID: 23648511.
      View in: PubMed
    52. Kaku Y, Ohmori T, Kudo K, Fujimura S, Suzuki K, Evans S, Kawakami Y, Nishinakamura R. Islet1 deletion causes kidney agenesis and hydroureter resembling CAKUT. J Am Soc Nephrol. 2013 Jul; 24(8):1242-9. PMID: 23641053; PMCID: PMC3736711.
    53. Cunningham TJ, Zhao X, Sandell LL, Evans S, Trainor PA, Duester G. Antagonism between retinoic acid and fibroblast growth factor signaling during limb development. Cell Rep. 2013 May 30; 3(5):1503-11. PMID: 23623500; PMCID: PMC3745640.
    54. Castagnaro L, Lenti E, Maruzzelli S, Spinardi L, Migliori E, Farinello D, Sitia G, Harrelson Z, Evans S, Guidotti LG, Harvey RP, Brendolan A. Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013 Apr 18; 38(4):782-91. PMID: 23601687; PMCID: PMC3652017.
    55. Boogerd CJ, Evans S. To activate or not to activate: the existential dilemma of an enhancer. Circ Res. 2013 Mar 29; 112(7):985-7. PMID: 23538274.
      View in: PubMed
    56. Banerjee I, Moore Morris T, Evans S, Chen J. Thymosin ß4 is not required for embryonic viability or vascular development. Circ Res. 2013 Feb 01; 112(3):e25-8. PMID: 23371905; PMCID: PMC3712119.
    57. Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans S, Graf D, Economides A, Haraguchi R, Moon AM, Yamada G. Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia. PLoS One. 2012; 7(9):e43453. PMID: 23028455; PMCID: PMC3444444.
    58. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans S, Nakano A, Mikkola HK. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 03; 150(3):590-605. PMID: 22863011; PMCID: PMC3624753.
    59. Sinha T, Wang B, Evans S, Wynshaw-Boris A, Wang J. Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol. 2012 Oct 01; 370(1):135-44. PMID: 22841628; PMCID: PMC3432663.
    60. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans S, Dillmann W, Glass CK, Brenner DA. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. PMID: 22566629; PMCID: PMC3386114.
    61. Itou J, Kawakami H, Quach T, Osterwalder M, Evans S, Zeller R, Kawakami Y. Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May; 139(9):1620-9. PMID: 22438573.
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    62. Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans S, Carrier L, Eschenhagen T. Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart. Circ Res. 2012 May 11; 110(10):1303-10. PMID: 22427341.
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    63. Bruggeman BJ, Maier JA, Mohiuddin YS, Powers R, Lo Y, Guimarães-Camboa N, Evans S, Harfe BD. Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc. Dev Dyn. 2012 Apr; 241(4):675-83. PMID: 22354863; PMCID: PMC3302952.
    64. Sakabe NJ, Aneas I, Shen T, Shokri L, Park SY, Bulyk ML, Evans S, Nobrega MA. Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function. Hum Mol Genet. 2012 May 15; 21(10):2194-204. PMID: 22328084; PMCID: PMC3335310.
    65. Harrelson Z, Kaestner KH, Evans S. Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis. Biol Open. 2012 Mar 15; 1(3):173-81. PMID: 23213408; PMCID: PMC3507292.
    66. Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans S, Chen J. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 03; 110(3):456-64. PMID: 22158707; PMCID: PMC3739283.
    67. Liu L, Suzuki K, Nakagata N, Mihara K, Matsumaru D, Ogino Y, Yashiro K, Hamada H, Liu Z, Evans S, Mendelsohn C, Yamada G. Retinoic acid signaling regulates sonic hedgehog and bone morphogenetic protein signalings during genital tubercle development. Birth Defects Res B Dev Reprod Toxicol. 2012 Feb; 95(1):79-88. PMID: 22127979.
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    68. Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans S. Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest. 2011 Dec; 121(12):4640-54. PMID: 22080862; PMCID: PMC3223071.
    69. Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans S, Tzahor E. The heart endocardium is derived from vascular endothelial progenitors. Development. 2011 Nov; 138(21):4777-87. PMID: 21989917; PMCID: PMC3190386.
    70. Lee SC, Cowgill EJ, Al-Nabulsi A, Quinn EJ, Evans S, Reese BE. Homotypic regulation of neuronal morphology and connectivity in the mouse retina. J Neurosci. 2011 Oct 05; 31(40):14126-33. PMID: 21976497; PMCID: PMC3204961.
    71. Hunt DL, Campbell PH, Zambon AC, Vranizan K, Evans S, Kuo HC, Yamaguchi KD, Omens JH, McCulloch AD. Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background. Exp Physiol. 2012 Jan; 97(1):102-14. PMID: 21967898; PMCID: PMC3253239.
    72. Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans S, Izpisua Belmonte JC. Islet1-mediated activation of the ß-catenin pathway is necessary for hindlimb initiation in mice. Development. 2011 Oct; 138(20):4465-73. PMID: 21937598; PMCID: PMC3177316.
    73. Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans S, Sun Y. Isl1 is required for multiple aspects of motor neuron development. Mol Cell Neurosci. 2011 Jul; 47(3):215-22. PMID: 21569850; PMCID: PMC3200226.
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    75. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans S, Knowlton KU, Sheikh F, Chen J. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62. PMID: 21303826; PMCID: PMC3071671.
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    77. Evans S, Yelon D, Conlon FL, Kirby ML. Myocardial lineage development. Circ Res. 2010 Dec 10; 107(12):1428-44. PMID: 21148449; PMCID: PMC3073310.
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    81. Miyagawa S, Moon A, Haraguchi R, Inoue C, Harada M, Nakahara C, Suzuki K, Matsumaru D, Kaneko T, Matsuo I, Yang L, Taketo MM, Iguchi T, Evans S, Yamada G. Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program. Development. 2009 Dec; 136(23):3969-78. PMID: 19906864; PMCID: PMC2778744.
    82. Song MR, Sun Y, Bryson A, Gill GN, Evans S, Pfaff SL. Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development. 2009 Sep; 136(17):2923-32. PMID: 19666821; PMCID: PMC2723064.
    83. Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans S, Chen J. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009 Aug 18; 120(7):568-76. PMID: 19652092; PMCID: PMC2738591.
    84. Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans S, Stein R, May CL. Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009 Sep; 58(9):2059-69. PMID: 19502415; PMCID: PMC2731519.
    85. Harel I, Nathan E, Tirosh-Finkel L, Zigdon H, Guimarães-Camboa N, Evans S, Tzahor E. Distinct origins and genetic programs of head muscle satellite cells. Dev Cell. 2009 Jun; 16(6):822-32. PMID: 19531353; PMCID: PMC3684422.
    86. Sun Y, Dykes IM, Liang X, Eng SR, Evans S, Turner EE. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov; 11(11):1283-93. PMID: 18849985; PMCID: PMC2605652.
    87. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans S, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. PMID: 18636119; PMCID: PMC2467382.
    88. Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans S. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 03; 454(7200):104-8. PMID: 18480752.
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    89. Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans S, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb; 135(4):647-57. PMID: 18184728.
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    90. Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans S. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct; 39(10):1225-34. PMID: 17767158.
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    91. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans S, Ding S, Chien KR. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 1(2):165-79. PMID: 18371348.
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    92. Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans S. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9313-8. PMID: 17519333; PMCID: PMC1890491.
    93. Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007 Mar 02; 100(4):527-35. PMID: 17272814.
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    94. Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans S. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 01; 304(1):286-96. PMID: 17258700; PMCID: PMC2582044.
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    96. Song MR, Shirasaki R, Cai CL, Ruiz EC, Evans S, Lee SK, Pfaff SL. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development. 2006 Dec; 133(24):4945-55. PMID: 17119020.
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    97. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans S, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. PMID: 17123592.
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    98. Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 2006 Aug 15; 296(2):437-49. PMID: 16836994.
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    99. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006 Jun; 133(12):2419-33. PMID: 16720879; PMCID: PMC1780034.
    100. Lin L, Bu L, Cai CL, Zhang X, Evans S. Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol. 2006 Jul 15; 295(2):756-63. PMID: 16687132.
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    101. Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr; 133(8):1575-85. PMID: 16556916.
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    102. Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development. 2005 May; 132(10):2475-87. PMID: 15843407.
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    103. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. PMID: 15703750.
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    104. Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans S, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30; 117(3):373-86. PMID: 15109497.
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    105. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell. 2003 Dec; 5(6):877-89. PMID: 14667410.
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    106. Garcia-Frigola C, Shi Y, Evans S. Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns. 2003 Dec; 3(6):777-83. PMID: 14643687.
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    107. Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J. Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development. 2003 Dec; 130(24):6111-9. PMID: 14573518.
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    108. Kondo RP, Anderson RH, Kupershmidt S, Roden DM, Evans S. Development of the cardiac conduction system as delineated by minK-lacZ. J Cardiovasc Electrophysiol. 2003 Apr; 14(4):383-91. PMID: 12741710.
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    109. Huang C, Zhou Q, Liang P, Hollander MS, Sheikh F, Li X, Greaser M, Shelton GD, Evans S, Chen J. Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem. 2003 Feb 28; 278(9):7360-5. PMID: 12499364.
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    110. Fu Y, Ruiz-Lozano P, Evans S. A rat homeobox gene, rNKx-2.5, is a homologue of the tinman gene in Drosophila and is mainly expressed during heart development. Dev Genes Evol. 1997 Nov; 207(5):352-358. PMID: 27747432.
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