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Shu Chien

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0412
La Jolla CA 92093
Phone858-534-5195
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    Collapse Research 
    Collapse Research Activities and Funding
    Locus-specific Imaging of Dynamic Histone Methylations during Reprogramming
    NIH/NIGMS R01GM125379Aug 3, 2017 - Apr 30, 2021
    Role: Co-Principal Investigator
    The Organizational Hub and Web Portal for the 4D Nucleome Network
    NIH/NCI U01CA200147Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under Flows
    NIH/NHLBI R01HL121365Dec 20, 2013 - Nov 30, 2021
    Role: Principal Investigator
    Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
    NIH/NHLBI R01HL108735Aug 24, 2012 - Jun 30, 2021
    Role: Principal Investigator
    Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular Homeostasis
    NIH/NHLBI R01HL106579Jan 1, 2011 - Nov 30, 2018
    Role: Principal Investigator
    Integrative Bioengineering of Heart, Vessels, and Blood
    NIH/NHLBI T32HL105373Sep 20, 2010 - Aug 31, 2020
    Role: Principal Investigator
    Optimization of the Chemical-Physical Environments for Stem Cell Differentiation
    NIH/NHLBI R21HL104402Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    UCSD MARC Program
    NIH/NIGMS T34GM087193Jun 1, 2009 - May 31, 2015
    Role: Principal Investigator
    Confocal Laser Scanning Biological Microscope Olympus Fv1000
    NIH/NCRR S10RR025630Apr 1, 2009 - Mar 31, 2010
    Role: Principal Investigator
    The Role of Phosphatases in EC Mechanotransduction
    NIH/NHLBI R01HL085159Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Mechanical Feedback on Cell Structure and Signaling
    NIH/NHLBI R01HL080518Feb 1, 2006 - Jan 31, 2011
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    MECHANISMS OF REPERFUSION INDUCTION OF ROS AND IKK
    NIH/NHLBI R01HL062747Feb 8, 2000 - Jan 31, 2004
    Role: Principal Investigator
    Mechanical and Molecular Bases of Endothelial Remodeling
    NIH/NHLBI R01HL064382Sep 28, 1999 - Jul 31, 2011
    Role: Principal Investigator
    1997 BIOMEDICAL ENGINEERING SOCIETY FALL MEETING
    NIH/NHLBI R13HL058979Sep 1, 1997 - Aug 31, 1998
    Role: Principal Investigator
    Biomechanics of the Heart, Vessels, and Blood Cells
    NIH/NHLBI P01HL043026Jul 1, 1990 - May 31, 2007
    Role: Principal Investigator
    BLOOD CELL PROPERTIES AND CIRCULATORY REGULATION
    NIH/NHLBI R37HL044147May 1, 1989 - Apr 30, 2000
    Role: Principal Investigator
    RHEOLOGY IN CARDIOVASCULAR DISEASES
    NIH/NHLBI T32HL007114Jul 1, 1980 - Aug 31, 1990
    Role: Principal Investigator
    HUMAN BLOOD CELL MEMBRANES IN HEALTH AND DISEASE
    NIH/NHLBI P01HL016851Jun 1, 1979 - May 31, 1990
    Role: Principal Investigator
    Molecular Mechanism of Endothelial Migration Under Flow
    NIH/NHLBI R01HL019454Dec 1, 1976 - Jun 30, 2006
    Role: Principal Investigator
    Cardiovascular Engineering Science
    NIH/NHLBI T32HL007089Jul 1, 1975 - Oct 3, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yu MC, Chiang CY, Lee JJ, Chien S, Lin CJ, Lee SW, Lin CB, Yang WT, Wu YH, Huang YW. Treatment outcomes of multidrug-resistant tuberculosis in Taiwan: tackling loss to follow-up. Clin Infect Dis. 2018 Jan 31. PMID: 29394358.
      View in: PubMed
    2. Pan Y, Yoon S, Sun J, Huang Z, Lee C, Allen M, Wu Y, Chang YJ, Sadelain M, Shung KK, Chien S, Wang Y. Mechanogenetics for the remote and noninvasive control of cancer immunotherapy. Proc Natl Acad Sci U S A. 2018 Jan 30; 115(5):992-997. PMID: 29343642.
      View in: PubMed
    3. Shentu TP, Huang TS, Cernelc-Kohan M, Chan J, Wong SS, Espinoza CR, Tan C, Gramaglia I, van der Heyde H, Chien S, Hagood JS. Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation. Sci Rep. 2017 Dec 22; 7(1):18052. PMID: 29273797.
      View in: PubMed
    4. Yeh YT, Serrano R, François J, Chiu JJ, Li YJ, Del Álamo JC, Chien S, Lasheras JC. Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis. Proc Natl Acad Sci U S A. 2018 Jan 02; 115(1):133-138. PMID: 29255056.
      View in: PubMed
    5. Wei X, Ying M, Dehaini D, Su Y, Kroll AV, Zhou J, Gao W, Fang RH, Chien S, Zhang L. Nanoparticle Functionalization with Platelet Membrane Enables Multifactored Biological Targeting and Detection of Atherosclerosis. ACS Nano. 2018 Jan 23; 12(1):109-116. PMID: 29216423.
      View in: PubMed
    6. Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10990-10995. PMID: 28973892.
      View in: PubMed
    7. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. PMID: 28500253.
      View in: PubMed
    8. Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11525-11530. PMID: 27671657.
      View in: PubMed
    9. Chien JY, Chien S, Chiu WY, Yu CJ, Hsueh PR. Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-Resistant Multidrug-Resistant Tuberculosis. Antimicrob Agents Chemother. 2016 08; 60(8):4708-16. PMID: 27216062; PMCID: PMC4958188 [Available on 02/01/17].
    10. Wu Y, Zhang K, Seong J, Fan J, Chien S, Wang Y, Lu S. In-situ coupling between kinase activities and protein dynamics within single focal adhesions. Sci Rep. 2016 Jul 07; 6:29377. PMID: 27383747; PMCID: PMC4935953.
    11. Bai KJ, Lee JJ, Chien S, Suk CW, Chiang CY. The Influence of Smoking on Pulmonary Tuberculosis in Diabetic and Non-Diabetic Patients. PLoS One. 2016; 11(6):e0156677. PMID: 27270725; PMCID: PMC4896632.
    12. Chien JY, Chiu WY, Chien S, Chiang CJ, Yu CJ, Hsueh PR. Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates. Antimicrob Agents Chemother. 2016 Apr; 60(4):2090-6. PMID: 26787695; PMCID: PMC4808166 [Available on 10/01/16].
    13. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. PMID: 26858399; PMCID: PMC4776497.
    14. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. PMID: 26733684; PMCID: PMC4725528.
    15. Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21. PMID: 26374997; PMCID: PMC4871317.
    16. Chien S, Bashir R, Nerem RM, Pettigrew R. Engineering as a new frontier for translational medicine. Sci Transl Med. 2015 Apr 01; 7(281):281fs13. PMID: 25834106.
      View in: PubMed
    17. Chiang CY, Bai KJ, Lin HH, Chien S, Lee JJ, Enarson DA, Lee TI, Yu MC. The influence of diabetes, glycemic control, and diabetes-related comorbidities on pulmonary tuberculosis. PLoS One. 2015; 10(3):e0121698. PMID: 25822974; PMCID: PMC4378948.
    18. Teng D, Pannell JS, Rennert RC, Li J, Li YS, Wong VW, Chien S, Khalessi AA. Endothelial trauma from mechanical thrombectomy in acute stroke: in vitro live-cell platform with animal validation. Stroke. 2015 Apr; 46(4):1099-106. PMID: 25712942.
      View in: PubMed
    19. Chen LJ, Chuang L, Huang YH, Zhou J, Lim SH, Lee CI, Lin WW, Lin TE, Wang WL, Chen L, Chien S, Chiu JJ. MicroRNA mediation of endothelial inflammatory response to smooth muscle cells and its inhibition by atheroprotective shear stress. Circ Res. 2015 Mar 27; 116(7):1157-69. PMID: 25623956; PMCID: PMC4380766.
    20. Chien S. Laudatio for Harry Goldsmith. Biorheology. 2015; 52(5-6):295-9. PMID: 26639361.
      View in: PubMed
    21. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. PMID: 25550450; PMCID: PMC4351177.
    22. Hu YL, Lu S, Szeto KW, Sun J, Wang Y, Lasheras JC, Chien S. FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep. 2014 Aug 12; 4:6024. PMID: 25113375; PMCID: PMC4129417.
    23. Lu S, Seong J, Wang Y, Chang SC, Eichorst JP, Ouyang M, Li JY, Chien S, Wang Y. Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells. Sci Rep. 2014 Jul 24; 4:5756. PMID: 25056908; PMCID: PMC4108961.
    24. Fuhrmann A, Li J, Chien S, Engler AJ. Cation type specific cell remodeling regulates attachment strength. PLoS One. 2014; 9(7):e102424. PMID: 25014042; PMCID: PMC4094514.
    25. Zhou J, Li YS, Wang KC, Chien S. Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1. Cell Mol Bioeng. 2014 Jun 01; 7(2):218-224. PMID: 24883126.
      View in: PubMed
    26. Zhou J, Li YS, Chien S. Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2191-8. PMID: 24876354; PMCID: PMC4169328.
    27. Wang KC, Nguyen P, Weiss A, Yeh YT, Chien HS, Lee A, Teng D, Subramaniam S, Li YS, Chien S. MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1437-45. PMID: 24855060; PMCID: PMC4119726.
    28. Chiang CY, Lee JJ, Chien S, Enarson DA, Chang YC, Chen YT, Hu TY, Lin CB, Suk CW, Tao JM, Bai KJ. Glycemic control and radiographic manifestations of tuberculosis in diabetic patients. PLoS One. 2014; 9(4):e93397. PMID: 24699457; PMCID: PMC3974751.
    29. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis EA, Gianneschi NC, Vecchio KS, Chien S, Lee OK, Varghese S. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. PMID: 24395775; PMCID: PMC3903237.
    30. Chien JY, Chien S, Huang SY, Yu CJ. Safety of rifabutin replacing rifampicin in the treatment of tuberculosis: a single-centre retrospective cohort study. J Antimicrob Chemother. 2014 Mar; 69(3):790-6. PMID: 24243988.
      View in: PubMed
    31. Qu X, Zhu W, Huang S, Li JY, Chien S, Zhang K, Chen S. Relative impact of uniaxial alignment vs. form-induced stress on differentiation of human adipose derived stem cells. Biomaterials. 2013 Dec; 34(38):9812-8. PMID: 24060419.
      View in: PubMed
    32. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. PMID: 23603512; PMCID: PMC3772783.
    33. Yeh YT, Hur SS, Chang J, Wang KC, Chiu JJ, Li YS, Chien S. Matrix stiffness regulates endothelial cell proliferation through septin 9. PLoS One. 2012; 7(10):e46889. PMID: 23118862; PMCID: PMC3485289.
    34. DuRose JB, Li J, Chien S, Spector DH. Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery. J Virol. 2012 Dec; 86(24):13745-55. PMID: 23055562; PMCID: PMC3503096.
    35. Chien S. UCSD's Institute of Engineering in Medicine: fostering collaboration through research and education. IEEE Pulse. 2012 Jul; 3(4):35-41. PMID: 22850836.
      View in: PubMed
    36. Hur SS, del Álamo JC, Park JS, Li YS, Nguyen HA, Teng D, Wang KC, Flores L, Alonso-Latorre B, Lasheras JC, Chien S. Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11110-5. PMID: 22665785; PMCID: PMC3396533.
    37. Brafman DA, Chien S, Willert K. Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations. Nat Protoc. 2012 Mar 15; 7(4):703-17. PMID: 22422316.
      View in: PubMed
    38. Altshuler AE, Morgan MJ, Chien S, Schmid-Schönbein GW. Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress. Cell Mol Bioeng. 2012 Mar; 5(1):82-91. PMID: 22545072.
      View in: PubMed
    39. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. PMID: 21636785; PMCID: PMC3121870.
    40. Chien S. A brief history of the Bioengineering Institute of California and the UC System-wide Symposia. Ann Biomed Eng. 2011 Apr; 39(4):1156-62. PMID: 21384235; PMCID: PMC3069316.
    41. Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials. 2010 Dec; 31(34):9135-44. PMID: 20817292; PMCID: PMC2949524.
    42. Lau CD, Levesque MJ, Chien S, Date S, Haga JH. ViewDock TDW: high-throughput visualization of virtual screening results. Bioinformatics. 2010 Aug 01; 26(15):1915-7. PMID: 20551133; PMCID: PMC2905552.
    43. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. PMID: 20133741; PMCID: PMC2840325.
    44. Yim WW, Chien S, Kusumoto Y, Date S, Haga J. Grid heterogeneity in in-silico experiments: an exploration of drug screening using DOCK on cloud environments. Stud Health Technol Inform. 2010; 159:181-90. PMID: 20543437.
      View in: PubMed
    45. Brafman DA, Shah KD, Fellner T, Chien S, Willert K. Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev. 2009 Oct; 18(8):1141-54. PMID: 19327010.
      View in: PubMed
    46. Chien S. A Tribute to Professor Van C. Mow: A Wonderful Scholar and Leader in Bioengineering. Cell Mol Bioeng. 2009 Sep; 2(3):282-284. PMID: 19779632.
      View in: PubMed
    47. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. PMID: 19696400; PMCID: PMC2766008.
    48. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. PMID: 20023766.
      View in: PubMed
    49. del Alamo JC, Norwich GN, Li YS, Lasheras JC, Chien S. Anisotropic rheology and directional mechanotransduction in vascular endothelial cells. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15411-6. PMID: 18840694; PMCID: PMC2563098.
    50. Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):216-20. PMID: 18474218; PMCID: PMC2587448.
    51. Chien S. Role of shear stress direction in endothelial mechanotransduction. Mol Cell Biomech. 2008 Mar; 5(1):1-8. PMID: 18524241.
      View in: PubMed
    52. Flaim CJ, Teng D, Chien S, Bhatia SN. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 2008 Feb; 17(1):29-39. PMID: 18271698.
      View in: PubMed
    53. Chien S. Effects of disturbed flow on endothelial cells. Ann Biomed Eng. 2008 Apr; 36(4):554-62. PMID: 18172767; PMCID: PMC3718045.
    54. Hornberger TA, Sukhija KB, Wang XR, Chien S. mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k). FEBS Lett. 2007 Oct 02; 581(24):4562-6. PMID: 17825298; PMCID: PMC2084087.
    55. Wang Y, Chang J, Chen KD, Li S, Li JY, Wu C, Chien S. Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8875-9. PMID: 17496149; PMCID: PMC1885595.
    56. D'Lima DD, Patil S, Steklov N, Chien S, Colwell CW. In vivo knee moments and shear after total knee arthroplasty. J Biomech. 2007; 40 Suppl 1:S11-7. PMID: 17462659.
      View in: PubMed
    57. Hu YL, Chien S. Dynamic motion of paxillin on actin filaments in living endothelial cells. Biochem Biophys Res Commun. 2007 Jun 15; 357(4):871-6. PMID: 17466945; PMCID: PMC2025639.
    58. Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S, Chien S. Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1254-9. PMID: 17229844; PMCID: PMC1783086.
    59. Chien S. Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1209-24. PMID: 17098825.
      View in: PubMed
    60. Hu YL, Haga JH, Miao H, Wang Y, Li YS, Chien S. Roles of microfilaments and microtubules in paxillin dynamics. Biochem Biophys Res Commun. 2006 Oct 06; 348(4):1463-71. PMID: 16920067.
      View in: PubMed
    61. Haga JH, Li YS, Chien S. Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J Biomech. 2007; 40(5):947-60. PMID: 16867303.
      View in: PubMed
    62. Hornberger TA, Sukhija KB, Chien S. Regulation of mTOR by mechanically induced signaling events in skeletal muscle. Cell Cycle. 2006 Jul; 5(13):1391-6. PMID: 16855395.
      View in: PubMed
    63. Hornberger TA, Chien S. Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J Cell Biochem. 2006 Apr 15; 97(6):1207-16. PMID: 16315321.
      View in: PubMed
    64. Wang Y, Jin G, Miao H, Li JY, Usami S, Chien S. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1774-9. PMID: 16446427; PMCID: PMC1413667.
    65. Wang N, Miao H, Li YS, Zhang P, Haga JH, Hu Y, Young A, Yuan S, Nguyen P, Wu CC, Chien S. Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1244-51. PMID: 16466697.
      View in: PubMed
    66. Chien S. Molecular basis of rheological modulation of endothelial functions: importance of stress direction. Biorheology. 2006; 43(2):95-116. PMID: 16687781.
      View in: PubMed
    67. Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens JH. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys. 2006; 46(2):113-22. PMID: 17012753; PMCID: PMC3310206.
    68. Kaunas R, Nguyen P, Usami S, Chien S. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15895-900. PMID: 16247009; PMCID: PMC1276069.
    69. Li YS, Haga JH, Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005 Oct; 38(10):1949-71. PMID: 16084198.
      View in: PubMed
    70. Chien S, Li S, Shiu YT, Li YS. Molecular basis of mechanical modulation of endothelial cell migration. Front Biosci. 2005 May 01; 10:1985-2000. PMID: 15769679.
      View in: PubMed
    71. Flaim CJ, Chien S, Bhatia SN. An extracellular matrix microarray for probing cellular differentiation. Nat Methods. 2005 Feb; 2(2):119-25. PMID: 15782209.
      View in: PubMed
    72. Miao H, Hu YL, Shiu YT, Yuan S, Zhao Y, Kaunas R, Wang Y, Jin G, Usami S, Chien S. Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res. 2005 Jan-Feb; 42(1):77-89. PMID: 15637443.
      View in: PubMed
    73. Makino A, Glogauer M, Bokoch GM, Chien S, Schmid-Schönbein GW. Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am J Physiol Cell Physiol. 2005 Apr; 288(4):C863-71. PMID: 15561759.
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    74. Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S. Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J. 2004 Apr; 86(4):2558-65. PMID: 15041692; PMCID: PMC1304103.
    75. Chien S. The National Institute of Biomedical Imaging and Bioengineering. Annu Rev Biomed Eng. 2004; 6:1-26. PMID: 15255760.
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    76. Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H685-92. PMID: 14551058.
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    77. Chien S. Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol. 2003 Oct; 83(2):131-51. PMID: 12865076.
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    78. Shiu YT, Li S, Yuan S, Wang Y, Nguyen P, Chien S. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun. 2003 Apr 04; 303(2):548-55. PMID: 12659853.
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    79. Zhao Y, Chen BP, Miao H, Yuan S, Li YS, Hu Y, Rocke DM, Chien S. Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes. Physiol Genomics. 2002 Dec 26; 12(1):1-11. PMID: 12399447.
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    80. Li S, Lao J, Chen BP, Li YS, Zhao Y, Chu J, Chen KD, Tsou TC, Peck K, Chien S. Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J. 2003 Jan; 17(1):97-9. PMID: 12475912.
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    81. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1540-7. PMID: 12372815.
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    82. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S. Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow. J Vasc Res. 2002 Nov-Dec; 39(6):465-76. PMID: 12566972.
      View in: PubMed
    83. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. PMID: 11973360.
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