Shu Chien

Title(s)Recall Faculty, Bioengineering
SchoolAcademic Aff
Address9500 Gilman Drive #0412
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Locus-specific Imaging of Dynamic Histone Methylations during Reprogramming
    NIH/NIGMS R01GM125379Aug 3, 2017 - Apr 30, 2021
    Role: Co-Principal Investigator
    The Organizational Hub and Web Portal for the 4D Nucleome Network
    NIH/NCI U01CA200147Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under Flows
    NIH/NHLBI R01HL121365Dec 20, 2013 - Nov 30, 2021
    Role: Principal Investigator
    Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
    NIH/NHLBI R01HL108735Aug 24, 2012 - Jun 30, 2021
    Role: Principal Investigator
    Nucleolin Regulation of miRome by Shear Stress
    NIH/NHLBI R01HL106579Jan 1, 2011 - Nov 30, 2022
    Role: Principal Investigator
    Integrative Bioengineering of Heart, Vessels, and Blood
    NIH/NHLBI T32HL105373Sep 20, 2010 - Aug 31, 2020
    Role: Principal Investigator
    Optimization of the Chemical-Physical Environments for Stem Cell Differentiation
    NIH/NHLBI R21HL104402Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    UCSD MARC Program
    NIH/NIGMS T34GM087193Jun 1, 2009 - May 31, 2015
    Role: Principal Investigator
    Confocal Laser Scanning Biological Microscope Olympus Fv1000
    NIH/NCRR S10RR025630Apr 1, 2009 - Mar 31, 2010
    Role: Principal Investigator
    The Role of Phosphatases in EC Mechanotransduction
    NIH/NHLBI R01HL085159Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Mechanical Feedback on Cell Structure and Signaling
    NIH/NHLBI R01HL080518Feb 1, 2006 - Jan 31, 2011
    Role: Principal Investigator
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NIH/NHLBI R01HL062747Feb 8, 2000 - Jan 31, 2004
    Role: Principal Investigator
    Mechanical and Molecular Bases of Endothelial Remodeling
    NIH/NHLBI R01HL064382Sep 28, 1999 - Jul 31, 2011
    Role: Principal Investigator
    NIH/NHLBI R13HL058979Sep 1, 1997 - Aug 31, 1998
    Role: Principal Investigator
    Biomechanics of the Heart, Vessels, and Blood Cells
    NIH/NHLBI P01HL043026Jul 1, 1990 - Sep 29, 1995
    Role: Principal Investigator
    NIH/NHLBI R37HL044147May 1, 1989 - Mar 31, 1994
    Role: Principal Investigator
    NIH/NHLBI T32HL007114Jul 1, 1980 - May 31, 1990
    Role: Principal Investigator
    NIH/NHLBI P01HL016851Jun 1, 1979 - May 31, 1990
    Role: Principal Investigator
    Molecular Mechanism of Endothelial Migration Under Flow
    NIH/NHLBI R01HL019454Dec 1, 1976 - Jun 30, 2006
    Role: Principal Investigator
    Cardiovascular Engineering Science
    NIH/NHLBI T32HL007089Jul 1, 1975 - Oct 3, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mutual-Aid Mobile App for Emergency Care: Feasibility Study. JMIR Form Res. 2020 Mar 19; 4(3):e15494. Chien SC, Islam MM, Yeh CA, Chien PH, Chen CY, Chin YP, Lin MC. PMID: 32191212.
      View in: PubMed   Mentions:
    2. Engineering light-controllable CAR T cells for cancer immunotherapy. Sci Adv. 2020 02; 6(8):eaay9209. Huang Z, Wu Y, Allen ME, Pan Y, Kyriakakis P, Lu S, Chang YJ, Wang X, Chien S, Wang Y. PMID: 32128416.
      View in: PubMed   Mentions:    Fields:    
    3. Incidences of Hypothyroidism Associated With Surgical Procedures for Thyroid Disorders: A Nationwide Population-Based Study. Front Pharmacol. 2019; 10:1378. Tsai SH, Chien SC, Nguyen PA, Chien PH, Ma HP, Asdary RN, Wang YC, Humayun A, Huang CL, Iqbal U, Jian WS. PMID: 31920634.
      View in: PubMed   Mentions:
    4. Association Between Atrial Fibrillation and Dementia: A Meta-Analysis. Front Aging Neurosci. 2019; 11:305. Islam MM, Poly TN, Walther BA, Yang HC, Wu CC, Lin MC, Chien SC, Li YC. PMID: 31780919.
      View in: PubMed   Mentions:
    5. Mapping RNA-chromatin interactions by sequencing with iMARGI. Nat Protoc. 2019 11; 14(11):3243-3272. Wu W, Yan Z, Nguyen TC, Bouman Chen Z, Chien S, Zhong S. PMID: 31619811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication. Arterioscler Thromb Vasc Biol. 2019 12; 39(12):2492-2504. Chang YJ, Li YS, Wu CC, Wang KC, Huang TC, Chen Z, Chien S. PMID: 31597449.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Does long-term use of antidiabetic drugs changes cancer risk? Medicine (Baltimore). 2019 Oct; 98(40):e17461. Liu YC, Nguyen PA, Humayun A, Chien SC, Yang HC, Asdary RN, Syed-Abdul S, Hsu MH, Moldovan M, Yen Y, Li YJ, Jian WS, Iqbal U. PMID: 31577776.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Extracellular RNA in a single droplet of human serum reflects physiologic and disease states. Proc Natl Acad Sci U S A. 2019 09 17; 116(38):19200-19208. Zhou Z, Wu Q, Yan Z, Zheng H, Chen CJ, Liu Y, Qi Z, Calandrelli R, Chen Z, Chien S, Su HI, Zhong S. PMID: 31481608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Dr. Y.C. Fung's Contributions to Biomechanics, Bioengineering and Humanity: Warmest Celebration for a Magnificent Centenarian. J Biomech Eng. 2019 Jun 19. Chien S. PMID: 31215621.
      View in: PubMed   Mentions:    Fields:    
    10. Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12974-12979. Gongol B, Marin T, Zhang J, Wang SC, Sun W, He M, Chen S, Chen L, Li J, Liu JH, Martin M, Han Y, Kang J, Johnson DA, Lytle C, Li YS, Huang PH, Chien S, Shyy JY. PMID: 31182601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arterioscler Thromb Vasc Biol. 2019 05; 39(5):902-914. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. PMID: 30917677.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells. Biomaterials. 2019 06; 204:59-69. Yeh YT, Wei J, Thorossian S, Nguyen K, Hoffman C, Del Álamo JC, Serrano R, Li YJ, Wang KC, Chien S. PMID: 30884320.
      View in: PubMed   Mentions: 1     Fields:    
    13. Genome-wide colocalization of RNA-DNA interactions and fusion RNA pairs. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3328-3337. Yan Z, Huang N, Wu W, Chen W, Jiang Y, Chen J, Huang X, Wen X, Xu J, Jin Q, Zhang K, Chen Z, Chien S, Zhong S. PMID: 30718424.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. Mechanogenetics for the remote and noninvasive control of cancer immunotherapy. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):992-997. Pan Y, Yoon S, Sun J, Huang Z, Lee C, Allen M, Wu Y, Chang YJ, Sadelain M, Shung KK, Chien S, Wang Y. PMID: 29343642.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation. Sci Rep. 2017 12 22; 7(1):18052. Shentu TP, Huang TS, Cernelc-Kohan M, Chan J, Wong SS, Espinoza CR, Tan C, Gramaglia I, van der Heyde H, Chien S, Hagood JS. PMID: 29273797.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):133-138. Yeh YT, Serrano R, François J, Chiu JJ, Li YJ, Del Álamo JC, Chien S, Lasheras JC. PMID: 29255056.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Nanoparticle Functionalization with Platelet Membrane Enables Multifactored Biological Targeting and Detection of Atherosclerosis. ACS Nano. 2018 01 23; 12(1):109-116. Wei X, Ying M, Dehaini D, Su Y, Kroll AV, Zhou J, Gao W, Fang RH, Chien S, Zhang L. PMID: 29216423.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10990-10995. Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. PMID: 28973892.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. PMID: 28500253.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11525-11530. Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S. PMID: 27671657.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    22. Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-Resistant Multidrug-Resistant Tuberculosis. Antimicrob Agents Chemother. 2016 08; 60(8):4708-16. Chien JY, Chien ST, Chiu WY, Yu CJ, Hsueh PR. PMID: 27216062.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. In-situ coupling between kinase activities and protein dynamics within single focal adhesions. Sci Rep. 2016 07 07; 6:29377. Wu Y, Zhang K, Seong J, Fan J, Chien S, Wang Y, Lu S. PMID: 27383747.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. The Influence of Smoking on Pulmonary Tuberculosis in Diabetic and Non-Diabetic Patients. PLoS One. 2016; 11(6):e0156677. Bai KJ, Lee JJ, Chien ST, Suk CW, Chiang CY. PMID: 27270725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates. Antimicrob Agents Chemother. 2016 Apr; 60(4):2090-6. Chien JY, Chiu WY, Chien ST, Chiang CJ, Yu CJ, Hsueh PR. PMID: 26787695.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    26. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. PMID: 26858399.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    27. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. PMID: 26733684.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21. Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. PMID: 26374997.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    29. Engineering as a new frontier for translational medicine. Sci Transl Med. 2015 Apr 01; 7(281):281fs13. Chien S, Bashir R, Nerem RM, Pettigrew R. PMID: 25834106.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. The influence of diabetes, glycemic control, and diabetes-related comorbidities on pulmonary tuberculosis. PLoS One. 2015; 10(3):e0121698. Chiang CY, Bai KJ, Lin HH, Chien ST, Lee JJ, Enarson DA, Lee TI, Yu MC. PMID: 25822974.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    31. Endothelial trauma from mechanical thrombectomy in acute stroke: in vitro live-cell platform with animal validation. Stroke. 2015 Apr; 46(4):1099-106. Teng D, Pannell JS, Rennert RC, Li J, Li YS, Wong VW, Chien S, Khalessi AA. PMID: 25712942.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    32. MicroRNA mediation of endothelial inflammatory response to smooth muscle cells and its inhibition by atheroprotective shear stress. Circ Res. 2015 Mar 27; 116(7):1157-69. Chen LJ, Chuang L, Huang YH, Zhou J, Lim SH, Lee CI, Lin WW, Lin TE, Wang WL, Chen L, Chien S, Chiu JJ. PMID: 25623956.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Laudatio for Harry Goldsmith. Biorheology. 2015; 52(5-6):295-9. Chien S. PMID: 26639361.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    34. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. PMID: 25550450.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. A Case of Takotsubo Cardiomyopathy Precipitated by Thyroid Storm and Diabetic Ketoacidosis with Poor Prognosis. Acta Cardiol Sin. 2014 Nov; 30(6):574-7. Wu WT, Hsu PC, Huang HL, Chen YC, Chien SC. PMID: 27122837.
      View in: PubMed   Mentions:
    36. FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep. 2014 Aug 12; 4:6024. Hu YL, Lu S, Szeto KW, Sun J, Wang Y, Lasheras JC, Chien S. PMID: 25113375.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    37. Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells. Sci Rep. 2014 Jul 24; 4:5756. Lu S, Seong J, Wang Y, Chang SC, Eichorst JP, Ouyang M, Li JY, Chien S, Wang Y. PMID: 25056908.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    38. Cation type specific cell remodeling regulates attachment strength. PLoS One. 2014; 9(7):e102424. Fuhrmann A, Li J, Chien S, Engler AJ. PMID: 25014042.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1. Cell Mol Bioeng. 2014 Jun 01; 7(2):218-224. Zhou J, Li YS, Wang KC, Chien S. PMID: 24883126.
      View in: PubMed   Mentions:
    40. Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2191-8. Zhou J, Li YS, Chien S. PMID: 24876354.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    41. MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1437-45. Wang KC, Nguyen P, Weiss A, Yeh YT, Chien HS, Lee A, Teng D, Subramaniam S, Li YS, Chien S. PMID: 24855060.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Glycemic control and radiographic manifestations of tuberculosis in diabetic patients. PLoS One. 2014; 9(4):e93397. Chiang CY, Lee JJ, Chien ST, Enarson DA, Chang YC, Chen YT, Hu TY, Lin CB, Suk CW, Tao JM, Bai KJ. PMID: 24699457.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    43. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis EA, Gianneschi NC, Vecchio KS, Chien S, Lee OK, Varghese S. PMID: 24395775.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    44. Relative impact of uniaxial alignment vs. form-induced stress on differentiation of human adipose derived stem cells. Biomaterials. 2013 Dec; 34(38):9812-8. Qu X, Zhu W, Huang S, Li JY, Chien S, Zhang K, Chen S. PMID: 24060419.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. PMID: 23603512.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    46. Matrix stiffness regulates endothelial cell proliferation through septin 9. PLoS One. 2012; 7(10):e46889. Yeh YT, Hur SS, Chang J, Wang KC, Chiu JJ, Li YS, Chien S. PMID: 23118862.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    47. Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery. J Virol. 2012 Dec; 86(24):13745-55. DuRose JB, Li J, Chien S, Spector DH. PMID: 23055562.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    48. UCSD's Institute of Engineering in Medicine: fostering collaboration through research and education. IEEE Pulse. 2012 Jul; 3(4):35-41. Chien S. PMID: 22850836.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11110-5. Hur SS, del Álamo JC, Park JS, Li YS, Nguyen HA, Teng D, Wang KC, Flores L, Alonso-Latorre B, Lasheras JC, Chien S. PMID: 22665785.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    50. Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations. Nat Protoc. 2012 Mar 15; 7(4):703-17. Brafman DA, Chien S, Willert K. PMID: 22422316.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    51. Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress. Cell Mol Bioeng. 2012 Mar; 5(1):82-91. Altshuler AE, Morgan MJ, Chien S, Schmid-Schönbein GW. PMID: 22545072.
      View in: PubMed   Mentions:
    52. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. PMID: 21636785.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    53. A brief history of the Bioengineering Institute of California and the UC System-wide Symposia. Ann Biomed Eng. 2011 Apr; 39(4):1156-62. Chien S. PMID: 21384235.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials. 2010 Dec; 31(34):9135-44. Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. PMID: 20817292.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    55. ViewDock TDW: high-throughput visualization of virtual screening results. Bioinformatics. 2010 Aug 01; 26(15):1915-7. Lau CD, Levesque MJ, Chien S, Date S, Haga JH. PMID: 20551133.
      View in: PubMed   Mentions: 1     Fields:    
    56. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. PMID: 20133741.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    57. Grid heterogeneity in in-silico experiments: an exploration of drug screening using DOCK on cloud environments. Stud Health Technol Inform. 2010; 159:181-90. Yim WW, Chien S, Kusumoto Y, Date S, Haga J. PMID: 20543437.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    58. Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev. 2009 Oct; 18(8):1141-54. Brafman DA, Shah KD, Fellner T, Chien S, Willert K. PMID: 19327010.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    59. A Tribute to Professor Van C. Mow: A Wonderful Scholar and Leader in Bioengineering. Cell Mol Bioeng. 2009 Sep; 2(3):282-284. Chien S. PMID: 19779632.
      View in: PubMed   Mentions:
    60. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. PMID: 19696400.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    61. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    62. Anisotropic rheology and directional mechanotransduction in vascular endothelial cells. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15411-6. del Alamo JC, Norwich GN, Li YS, Lasheras JC, Chien S. PMID: 18840694.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    63. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):216-20. Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM. PMID: 18474218.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    64. Role of shear stress direction in endothelial mechanotransduction. Mol Cell Biomech. 2008 Mar; 5(1):1-8. Chien S. PMID: 18524241.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    65. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 2008 Feb; 17(1):29-39. Flaim CJ, Teng D, Chien S, Bhatia SN. PMID: 18271698.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    66. Effects of disturbed flow on endothelial cells. Ann Biomed Eng. 2008 Apr; 36(4):554-62. Chien S. PMID: 18172767.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    67. mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k). FEBS Lett. 2007 Oct 02; 581(24):4562-6. Hornberger TA, Sukhija KB, Wang XR, Chien S. PMID: 17825298.
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    68. Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8875-9. Wang Y, Chang J, Chen KD, Li S, Li JY, Wu C, Chien S. PMID: 17496149.
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    69. In vivo knee moments and shear after total knee arthroplasty. J Biomech. 2007; 40 Suppl 1:S11-7. D'Lima DD, Patil S, Steklov N, Chien S, Colwell CW. PMID: 17462659.
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    70. Dynamic motion of paxillin on actin filaments in living endothelial cells. Biochem Biophys Res Commun. 2007 Jun 15; 357(4):871-6. Hu YL, Chien S. PMID: 17466945.
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    71. Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1254-9. Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S, Chien S. PMID: 17229844.
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    72. Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1209-24. Chien S. PMID: 17098825.
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    73. Roles of microfilaments and microtubules in paxillin dynamics. Biochem Biophys Res Commun. 2006 Oct 06; 348(4):1463-71. Hu YL, Haga JH, Miao H, Wang Y, Li YS, Chien S. PMID: 16920067.
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    74. Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J Biomech. 2007; 40(5):947-60. Haga JH, Li YS, Chien S. PMID: 16867303.
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    75. Regulation of mTOR by mechanically induced signaling events in skeletal muscle. Cell Cycle. 2006 Jul; 5(13):1391-6. Hornberger TA, Sukhija KB, Chien S. PMID: 16855395.
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    76. Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J Cell Biochem. 2006 Apr 15; 97(6):1207-16. Hornberger TA, Chien S. PMID: 16315321.
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    77. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1774-9. Wang Y, Jin G, Miao H, Li JY, Usami S, Chien S. PMID: 16446427.
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    78. Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1244-51. Wang N, Miao H, Li YS, Zhang P, Haga JH, Hu Y, Young A, Yuan S, Nguyen P, Wu CC, Chien S. PMID: 16466697.
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    79. Molecular basis of rheological modulation of endothelial functions: importance of stress direction. Biorheology. 2006; 43(2):95-116. Chien S. PMID: 16687781.
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    80. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys. 2006; 46(2):113-22. Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens JH. PMID: 17012753.
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    81. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15895-900. Kaunas R, Nguyen P, Usami S, Chien S. PMID: 16247009.
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    82. Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005 Oct; 38(10):1949-71. Li YS, Haga JH, Chien S. PMID: 16084198.
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    83. Molecular basis of mechanical modulation of endothelial cell migration. Front Biosci. 2005 May 01; 10:1985-2000. Chien S, Li S, Shiu YT, Li YS. PMID: 15769679.
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    84. An extracellular matrix microarray for probing cellular differentiation. Nat Methods. 2005 Feb; 2(2):119-25. Flaim CJ, Chien S, Bhatia SN. PMID: 15782209.
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    85. Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res. 2005 Jan-Feb; 42(1):77-89. Miao H, Hu YL, Shiu YT, Yuan S, Zhao Y, Kaunas R, Wang Y, Jin G, Usami S, Chien S. PMID: 15637443.
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    86. Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am J Physiol Cell Physiol. 2005 Apr; 288(4):C863-71. Makino A, Glogauer M, Bokoch GM, Chien S, Schmid-Schönbein GW. PMID: 15561759.
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    87. Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J. 2004 Apr; 86(4):2558-65. Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S. PMID: 15041692.
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    88. The National Institute of Biomedical Imaging and Bioengineering. Annu Rev Biomed Eng. 2004; 6:1-26. Chien S. PMID: 15255760.
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    89. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H685-92. Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. PMID: 14551058.
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    90. Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol. 2003 Oct; 83(2):131-51. Chien S. PMID: 12865076.
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    91. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun. 2003 Apr 04; 303(2):548-55. Shiu YT, Li S, Yuan S, Wang Y, Nguyen P, Chien S. PMID: 12659853.
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    92. Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes. Physiol Genomics. 2002 Dec 26; 12(1):1-11. Zhao Y, Chen BP, Miao H, Yuan S, Li YS, Hu Y, Rocke DM, Chien S. PMID: 12399447.
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    93. Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J. 2003 Jan; 17(1):97-9. Li S, Lao J, Chen BP, Li YS, Zhao Y, Chu J, Chen KD, Tsou TC, Peck K, Chien S. PMID: 12475912.
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    94. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1540-7. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. PMID: 12372815.
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    95. Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow. J Vasc Res. 2002 Nov-Dec; 39(6):465-76. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S. PMID: 12566972.
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    96. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. PMID: 11973360.
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    97. Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells. Biochem Biophys Res Commun. 2002 Apr 12; 292(4):892-9. Miao H, Yuan S, Wang Y, Tsygankov A, Chien S. PMID: 11944898.
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    98. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3546-51. Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. PMID: 11891289.
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    99. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):76-81. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. PMID: 11788464.
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    100. Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids: a role for membrane perturbation in shear-induced MAPK activation. FASEB J. 2002 Feb; 16(2):216-8. Butler PJ, Tsou TC, Li JY, Usami S, Chien S. PMID: 11744620.
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