Michael Middleton

Title(s)RECALL NON-FACULTY ACAD NEX, Radiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, IrvineMD1985Medicine
    University of CambridgePhD1979Physics
    California State UniversityBSc1972Physics
    University of California, San DiegoResidency1990Radiology
    Mercy Hospital Mercy Hospital (Transitional Internship)Internship1986
    Collapse Awards and Honors
    Metrohealth Medical Center, Case Western University2013Visiting Professor
    Memorial Sloan Kettering Hospital2010Visiting Professor
    Metrohealth Medical Center, Case Western University2008Visiting Professor
    University of California, Irvine1985Vincent P. Carroll Research Award
    University of Cambridge1975  - 1978James Clerk Maxwell Scholarship
    California State University1972B.Sc. with honors, cum laude
    University of Dundee (Scotland)1971  - 1972Study Abroad Program

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium. Radiology. 2023 10; 309(1):e231092. Fowler KJ, Venkatesh SK, Obuchowski N, Middleton MS, Chen J, Pepin K, Magnuson J, Brown KJ, Batakis D, Henderson WC, Shankar SS, Kamphaus TN, Pasek A, Calle RA, Sanyal AJ, Loomba R, Ehman R, Samir AE, Sirlin CB, Sherlock SP. PMID: 37815451; PMCID: PMC10625902.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Deep Learning for Inference of Hepatic Proton Density Fat Fraction From T1-Weighted In-Phase and Opposed-Phase MRI: Retrospective Analysis of Population-Based Trial Data. AJR Am J Roentgenol. 2023 11; 221(5):620-631. Wang K, Cunha GM, Hasenstab K, Henderson WC, Middleton MS, Cole SA, Umans JG, Ali T, Hsiao A, Sirlin CB. PMID: 37466189.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Association of Hepatic Steatosis with Adipose and Muscle Mass and Distribution in Children. Metab Syndr Relat Disord. 2023 05; 21(4):222-230. Malki GJ, Goyal NP, Ugalde-Nicalo P, Chun LF, Zhang J, Ding Z, Wei Y, Knott C, Batakis D, Henderson W, Sirlin CB, Middleton MS, Schwimmer JB. PMID: 37083405; PMCID: PMC10181799.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis. J Hepatol. 2023 02; 78(2):238-246. Shen W, Middleton MS, Cunha GM, Delgado TI, Wolfson T, Gamst A, Fowler KJ, Alazraki A, Trout AT, Ohliger MA, Shah SN, Bashir MR, Kleiner DE, Loomba R, Neuschwander-Tetri BA, Sanyal AJ, Zhou J, Sirlin CB, Lavine JE. PMID: 36368598; PMCID: PMC9852022.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials. Radiology. 2023 03; 306(3):e220743. Nedrud MA, Chaudhry M, Middleton MS, Moylan CA, Lerebours R, Luo S, Farjat A, Guy C, Loomba R, Abdelmalek MF, Sirlin CB, Bashir MR. PMID: 36318027; PMCID: PMC9968769.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Automated CNN-Based Analysis Versus Manual Analysis for MR Elastography in Nonalcoholic Fatty Liver Disease: Intermethod Agreement and Fibrosis Stage Discriminative Performance. AJR Am J Roentgenol. 2022 08; 219(2):224-232. Cunha GM, Delgado TI, Middleton MS, Liew S, Henderson WC, Batakis D, Wang K, Loomba R, Huss RS, Myers RP, Sirlin CB, Fowler KJ, Hasenstab KA. PMID: 35107306.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. MR elastography in nonalcoholic fatty liver disease: inter-center and inter-analysis-method measurement reproducibility and accuracy at 3T. Eur Radiol. 2022 May; 32(5):2937-2948. Tang A, Dzyubak B, Yin M, Schlein A, Henderson WC, Hooker JC, Delgado TI, Middleton MS, Zheng L, Wolfson T, Gamst A, Loomba R, Ehman RL, Sirlin CB. PMID: 34928415; PMCID: PMC9038857.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Optimal Threshold of Controlled Attenuation Parameter for Detection of HIV-Associated NAFLD With Magnetic Resonance Imaging as the Reference Standard. Clin Infect Dis. 2021 06 15; 72(12):2124-2131. Ajmera VH, Cachay ER, Ramers CB, Bassirian S, Singh S, Bettencourt R, Richards L, Hamilton G, Middleton M, Fowler K, Sirlin C, Loomba R. PMID: 32975278; PMCID: PMC8204791.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis. Eur Radiol. 2021 Nov; 31(11):8408-8419. Qu Y, Middleton MS, Loomba R, Glaser KJ, Chen J, Hooker JC, Wolfson T, Covarrubias Y, Valasek MA, Fowler KJ, Zhang YN, Sy E, Gamst AC, Wang K, Mamidipalli A, Schwimmer JB, Song B, Reeder SB, Yin M, Ehman RL, Sirlin CB. PMID: 33899143; PMCID: PMC8530863.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children. J Pediatr Gastroenterol Nutr. 2021 04 01; 72(4):e90-e96. Sawh MC, Wallace M, Shapiro E, Goyal NP, Newton KP, Yu EL, Bross C, Durelle J, Knott C, Gangoiti JA, Barshop BA, Gengatharan JM, Meurs N, Schlein A, Middleton MS, Sirlin CB, Metallo CM, Schwimmer JB. PMID: 33399331; PMCID: PMC8842839.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    11. Repeatability and accuracy of various region-of-interest sampling strategies for hepatic MRI proton density fat fraction quantification. Abdom Radiol (NY). 2021 07; 46(7):3105-3116. Hong CW, Cui JY, Batakis D, Xu Y, Wolfson T, Gamst AC, Schlein AN, Negrete LM, Middleton MS, Hamilton G, Loomba R, Schwimmer JB, Fowler KJ, Sirlin CB. PMID: 33609166; PMCID: PMC8983333.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Temperature-corrected proton density fat fraction estimation using chemical shift-encoded MRI in phantoms. Magn Reson Med. 2021 07; 86(1):69-81. Navaratna R, Zhao R, Colgan TJ, Hu HH, Bydder M, Yokoo T, Bashir MR, Middleton MS, Serai SD, Malyarenko D, Chenevert T, Smith M, Henderson W, Hamilton G, Shu Y, Sirlin CB, Tkach JA, Trout AT, Brittain JH, Hernando D, Reeder SB, RSNA Quantitative Imaging Biomarker Alliance - Proton Density Fat Fraction Biomarker Committee. PMID: 33565112; PMCID: PMC8432757.
      View in: PubMed   Mentions: 5     Fields:    
    13. Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children. J Pediatr. 2021 06; 233:105-111.e3. Chun LF, Yu EL, Sawh MC, Bross C, Nichols J, Polgreen L, Knott C, Schlein A, Sirlin CB, Middleton MS, Kado DM, Schwimmer JB. PMID: 33545191; PMCID: PMC8154638.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Linearity and Bias of Proton Density Fat Fraction as a Quantitative Imaging Biomarker: A Multicenter, Multiplatform, Multivendor Phantom Study. Radiology. 2021 03; 298(3):640-651. Hu HH, Yokoo T, Bashir MR, Sirlin CB, Hernando D, Malyarenko D, Chenevert TL, Smith MA, Serai SD, Middleton MS, Henderson WC, Hamilton G, Shaffer J, Shu Y, Tkach JA, Trout AT, Obuchowski N, Brittain JH, Jackson EF, Reeder SB, RSNA Quantitative Imaging Biomarkers Alliance PDFF Biomarker Committee. PMID: 33464181; PMCID: PMC7924516.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    15. Multicenter Validation of Association Between Decline in MRI-PDFF and Histologic Response in NASH. Hepatology. 2020 10; 72(4):1219-1229. Loomba R, Neuschwander-Tetri BA, Sanyal A, Chalasani N, Diehl AM, Terrault N, Kowdley K, Dasarathy S, Kleiner D, Behling C, Lavine J, Van Natta M, Middleton M, Tonascia J, Sirlin C, NASH Clinical Research Network. PMID: 31965579; PMCID: PMC8055244.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCTClinical Trials
    16. Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial. Hepatology. 2020 07; 72(1):58-71. Patel K, Harrison SA, Elkhashab M, Trotter JF, Herring R, Rojter SE, Kayali Z, Wong VW, Greenbloom S, Jayakumar S, Shiffman ML, Freilich B, Lawitz EJ, Gane EJ, Harting E, Xu J, Billin AN, Chung C, Djedjos CS, Subramanian GM, Myers RP, Middleton MS, Rinella M, Noureddin M. PMID: 32115759.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCTClinical Trials
    17. Prospective comparison of longitudinal change in hepatic proton density fat fraction (PDFF) estimated by magnitude-based MRI (MRI-M) and complex-based MRI (MRI-C). Eur Radiol. 2020 Sep; 30(9):5120-5129. Mamidipalli A, Fowler KJ, Hamilton G, Wolfson T, Covarrubias Y, Tran C, Fazeli S, Wiens CN, McMillan A, Artz NS, Funk LM, Campos GM, Greenberg JA, Gamst A, Middleton MS, Schwimmer JB, Reeder SB, Sirlin CB. PMID: 32318847; PMCID: PMC7495399.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. The relationship between liver triglyceride composition and proton density fat fraction as assessed by 1 H MRS. NMR Biomed. 2020 06; 33(6):e4286. Hamilton G, Schlein AN, Wolfson T, Cunha GM, Fowler KJ, Middleton MS, Loomba R, Sirlin CB. PMID: 32128921; PMCID: PMC7211117.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Accuracy of common proton density fat fraction thresholds for magnitude- and complex-based chemical shift-encoded MRI for assessing hepatic steatosis in patients with obesity. Abdom Radiol (NY). 2020 03; 45(3):661-671. Cunha GM, Thai TT, Hamilton G, Covarrubias Y, Schlein A, Middleton MS, Wiens CN, McMillan A, Agni R, Funk LM, Campos GM, Horgan S, Jacobson G, Wolfson T, Gamst A, Schwimmer JB, Reeder SB, Sirlin CB. PMID: 31781899; PMCID: PMC8108484.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    20. Evaluation of Quantitative Imaging Biomarkers for Early-phase Clinical Trials of Steatohepatitis in Adolescents. J Pediatr Gastroenterol Nutr. 2020 01; 70(1):99-105. Goyal NP, Sawh MC, Ugalde-Nicalo P, Angeles JE, Proudfoot JA, Newton KP, Middleton MS, Sirlin CB, Schwimmer JB. PMID: 31633654; PMCID: PMC8053386.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Automated CT and MRI Liver Segmentation and Biometry Using a Generalized Convolutional Neural Network. Radiol Artif Intell. 2019 Mar; 1(2). Wang K, Mamidipalli A, Retson T, Bahrami N, Hasenstab K, Blansit K, Bass E, Delgado T, Cunha G, Middleton MS, Loomba R, Neuschwander-Tetri BA, Sirlin CB, Hsiao A, members of the NASH Clinical Research Network. PMID: 32582883; PMCID: PMC7314107.
      View in: PubMed   Mentions: 40  
    22. Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial. JAMA. 2019 01 22; 321(3):256-265. Schwimmer JB, Ugalde-Nicalo P, Welsh JA, Angeles JE, Cordero M, Harlow KE, Alazraki A, Durelle J, Knight-Scott J, Newton KP, Cleeton R, Knott C, Konomi J, Middleton MS, Travers C, Sirlin CB, Hernandez A, Sekkarie A, McCracken C, Vos MB. PMID: 30667502; PMCID: PMC6440226.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    23. Prevalence of Nonalcoholic Fatty Liver Disease in Children with Obesity. J Pediatr. 2019 04; 207:64-70. Yu EL, Golshan S, Harlow KE, Angeles JE, Durelle J, Goyal NP, Newton KP, Sawh MC, Hooker J, Sy EZ, Middleton MS, Sirlin CB, Schwimmer JB. PMID: 30559024; PMCID: PMC6440815.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    24. Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease. J Magn Reson Imaging. 2019 05; 49(5):1456-1466. Bashir MR, Wolfson T, Gamst AC, Fowler KJ, Ohliger M, Shah SN, Alazraki A, Trout AT, Behling C, Allende DS, Loomba R, Sanyal A, Schwimmer J, Lavine JE, Shen W, Tonascia J, Van Natta ML, Mamidipalli A, Hooker J, Kowdley KV, Middleton MS, Sirlin CB, NASH Clinical Research Network (NASH CRN). PMID: 30318834; PMCID: PMC6449180.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    25. Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib. J Hepatol. 2019 01; 70(1):133-141. Jayakumar S, Middleton MS, Lawitz EJ, Mantry PS, Caldwell SH, Arnold H, Mae Diehl A, Ghalib R, Elkhashab M, Abdelmalek MF, Kowdley KV, Stephen Djedjos C, Xu R, Han L, Mani Subramanian G, Myers RP, Goodman ZD, Afdhal NH, Charlton MR, Sirlin CB, Loomba R. PMID: 30291868.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCTClinical Trials
    26. GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 11; 155(5):1463-1473.e6. Loomba R, Kayali Z, Noureddin M, Ruane P, Lawitz EJ, Bennett M, Wang L, Harting E, Tarrant JM, McColgan BJ, Chung C, Ray AS, Subramanian GM, Myers RP, Middleton MS, Lai M, Charlton M, Harrison SA. PMID: 30059671; PMCID: PMC6318218.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCTClinical Trials
    27. Assessment of a high-SNR chemical-shift-encoded MRI with complex reconstruction for proton density fat fraction (PDFF) estimation overall and in the low-fat range. J Magn Reson Imaging. 2019 01; 49(1):229-238. Park CC, Hooker C, Hooker JC, Bass E, Haufe W, Schlein A, Covarrubias Y, Heba E, Bydder M, Wolfson T, Gamst A, Loomba R, Schwimmer J, Hernando D, Reeder SB, Middleton M, Sirlin CB, Hamilton G. PMID: 29707848; PMCID: PMC6205914.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2018 12; 16(12):1983-1991.e3. Lawitz EJ, Coste A, Poordad F, Alkhouri N, Loo N, McColgan BJ, Tarrant JM, Nguyen T, Han L, Chung C, Ray AS, McHutchison JG, Subramanian GM, Myers RP, Middleton MS, Sirlin C, Loomba R, Nyangau E, Fitch M, Li K, Hellerstein M. PMID: 29705265.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    29. Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 08; 155(2):307-310.e2. Ajmera V, Park CC, Caussy C, Singh S, Hernandez C, Bettencourt R, Hooker J, Sy E, Behling C, Xu R, Middleton MS, Valasek MA, Faulkner C, Rizo E, Richards L, Sirlin CB, Loomba R. PMID: 29660324; PMCID: PMC6090543.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    30. Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease. Hepatology. 2018 03; 67(3):858-872. Middleton MS, Van Natta ML, Heba ER, Alazraki A, Trout AT, Masand P, Brunt EM, Kleiner DE, Doo E, Tonascia J, Lavine JE, Shen W, Hamilton G, Schwimmer JB, Sirlin CB, NASH Clinical Research Network. PMID: 29028128; PMCID: PMC6211296.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCTClinical Trials
    31. Repeatability and reproducibility of 2D and 3D hepatic MR elastography with rigid and flexible drivers at end-expiration and end-inspiration in healthy volunteers. Abdom Radiol (NY). 2017 12; 42(12):2843-2854. Wang K, Manning P, Szeverenyi N, Wolfson T, Hamilton G, Middleton MS, Vaida F, Yin M, Glaser K, Ehman RL, Sirlin CB. PMID: 28612163; PMCID: PMC5698170.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    32. Magnetic resonance elastography measured shear stiffness as a biomarker of fibrosis in pediatric nonalcoholic fatty liver disease. Hepatology. 2017 11; 66(5):1474-1485. Schwimmer JB, Behling C, Angeles JE, Paiz M, Durelle J, Africa J, Newton KP, Brunt EM, Lavine JE, Abrams SH, Masand P, Krishnamurthy R, Wong K, Ehman RL, Yin M, Glaser KJ, Dzyubak B, Wolfson T, Gamst AC, Hooker J, Haufe W, Schlein A, Hamilton G, Middleton MS, Sirlin CB. PMID: 28493388; PMCID: PMC5650504.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    33. Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis. Radiology. 2018 02; 286(2):486-498. Yokoo T, Serai SD, Pirasteh A, Bashir MR, Hamilton G, Hernando D, Hu HH, Hetterich H, Kühn JP, Kukuk GM, Loomba R, Middleton MS, Obuchowski NA, Song JS, Tang A, Wu X, Reeder SB, Sirlin CB, RSNA-QIBA PDFF Biomarker Committee. PMID: 28892458; PMCID: PMC5813433.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    34. MRI proton density fat fraction is robust across the biologically plausible range of triglyceride spectra in adults with nonalcoholic steatohepatitis. J Magn Reson Imaging. 2018 04; 47(4):995-1002. Hong CW, Mamidipalli A, Hooker JC, Hamilton G, Wolfson T, Chen DH, Fazeli Dehkordy S, Middleton MS, Reeder SB, Loomba R, Sirlin CB. PMID: 28851124; PMCID: PMC5832550.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    35. Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis. Gastroenterology. 2017 09; 153(3):753-761. Middleton MS, Heba ER, Hooker CA, Bashir MR, Fowler KJ, Sandrasegaran K, Brunt EM, Kleiner DE, Doo E, Van Natta ML, Lavine JE, Neuschwander-Tetri BA, Sanyal A, Loomba R, Sirlin CB, NASH Clinical Research Network. PMID: 28624576; PMCID: PMC5695870.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCTClinical Trials
    36. Cross-sectional correlation between hepatic R2* and proton density fat fraction (PDFF) in children with hepatic steatosis. J Magn Reson Imaging. 2018 02; 47(2):418-424. Mamidipalli A, Hamilton G, Manning P, Hong CW, Park CC, Wolfson T, Hooker J, Heba E, Schlein A, Gamst A, Durelle J, Paiz M, Middleton MS, Schwimmer JB, Sirlin CB. PMID: 28543915; PMCID: PMC5702271.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    37. Effect of intravenous gadoxetate disodium and flip angle on hepatic proton density fat fraction estimation with six-echo, gradient-recalled-echo, magnitude-based MR imaging at 3T. Abdom Radiol (NY). 2017 04; 42(4):1189-1198. Park CC, Hamilton G, Desai A, Zand KA, Wolfson T, Hooker JC, Costa E, Heba E, Clark L, Gamst A, Loomba R, Middleton MS, Sirlin CB. PMID: 28028556.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Accuracy of PDFF estimation by magnitude-based and complex-based MRI in children with MR spectroscopy as a reference. J Magn Reson Imaging. 2017 12; 46(6):1641-1647. Haufe WM, Wolfson T, Hooker CA, Hooker JC, Covarrubias Y, Schlein AN, Hamilton G, Middleton MS, Angeles JE, Hernando D, Reeder SB, Schwimmer JB, Sirlin CB. PMID: 28323377; PMCID: PMC5608618.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    39. Quantifying Abdominal Adipose Tissue and Thigh Muscle Volume and Hepatic Proton Density Fat Fraction: Repeatability and Accuracy of an MR Imaging-based, Semiautomated Analysis Method. Radiology. 2017 05; 283(2):438-449. Middleton MS, Haufe W, Hooker J, Borga M, Dahlqvist Leinhard O, Romu T, Tunón P, Hamilton G, Wolfson T, Gamst A, Loomba R, Sirlin CB. PMID: 28278002; PMCID: PMC5410959.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    40. Agreement between region-of-interest- and parametric map-based hepatic proton density fat fraction estimation in adults with chronic liver disease. Abdom Radiol (NY). 2017 03; 42(3):833-841. Manning PM, Hamilton G, Wang K, Park C, Hooker JC, Wolfson T, Gamst A, Haufe WM, Schlein AN, Middleton MS, Sirlin CB. PMID: 27688063; PMCID: PMC5357163.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Liver histology and diffusion-weighted MRI in children with nonalcoholic fatty liver disease: A MAGNET study. J Magn Reson Imaging. 2017 10; 46(4):1149-1158. Manning P, Murphy P, Wang K, Hooker J, Wolfson T, Middleton MS, Newton KP, Behling C, Awai HI, Durelle J, Paiz MN, Angeles JE, De La Pena D, McCutchan JA, Schwimmer JB, Sirlin CB. PMID: 28225568; PMCID: PMC5568908.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. In vivo triglyceride composition of abdominal adipose tissue measured by 1 H MRS at 3T. J Magn Reson Imaging. 2017 05; 45(5):1455-1463. Hamilton G, Schlein AN, Middleton MS, Hooker CA, Wolfson T, Gamst AC, Loomba R, Sirlin CB. PMID: 27571403; PMCID: PMC5332519.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    43. Intravenous Gadoxetate Disodium Administration Reduces Breath-holding Capacity in the Hepatic Arterial Phase: A Multi-Center Randomized Placebo-controlled Trial. Radiology. 2017 Feb; 282(2):361-368. McClellan TR, Motosugi U, Middleton MS, Allen BC, Jaffe TA, Miller CM, Reeder SB, Sirlin CB, Bashir MR. PMID: 27509544; PMCID: PMC5537625.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    44. Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging. Radiology. 2016 Oct; 281(1):129-39. Tanabe M, Kanki A, Wolfson T, Costa EA, Mamidipalli A, Ferreira MP, Santillan C, Middleton MS, Gamst AC, Kono Y, Kuo A, Sirlin CB. PMID: 27115054.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    45. Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease. Abdom Imaging. 2015 Oct; 40(8):3084-90. Achmad E, Yokoo T, Hamilton G, Heba ER, Hooker JC, Changchien C, Schroeder M, Wolfson T, Gamst A, Schwimmer JB, Lavine JE, Sirlin CB, Middleton MS. PMID: 26205992; PMCID: PMC4630122.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    46. Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. Abdom Imaging. 2015 Oct; 40(8):3070-7. Tyagi A, Yeganeh O, Levin Y, Hooker JC, Hamilton GC, Wolfson T, Gamst A, Zand AK, Heba E, Loomba R, Schwimmer J, Middleton MS, Sirlin CB. PMID: 26350282; PMCID: PMC4819976.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    47. Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T. Biomed Res Int. 2015; 2015:387653. Yokoo T, Wolfson T, Iwaisako K, Peterson MR, Mani H, Goodman Z, Changchien C, Middleton MS, Gamst AC, Mazhar SM, Kono Y, Ho SB, Sirlin CB. PMID: 26421287; PMCID: PMC4569760.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    48. Accuracy and the effect of possible subject-based confounders of magnitude-based MRI for estimating hepatic proton density fat fraction in adults, using MR spectroscopy as reference. J Magn Reson Imaging. 2016 Feb; 43(2):398-406. Heba ER, Desai A, Zand KA, Hamilton G, Wolfson T, Schlein AN, Gamst A, Loomba R, Sirlin CB, Middleton MS. PMID: 26201284; PMCID: PMC4819980.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    49. In vivo breath-hold (1) H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence. J Magn Reson Imaging. 2015 Dec; 42(6):1538-43. Hamilton G, Middleton MS, Hooker JC, Haufe WM, Forbang NI, Allison MA, Loomba R, Sirlin CB. PMID: 26114603; PMCID: PMC4691228.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    50. Diagnostic Accuracy of Preoperative Gadoxetic Acid-enhanced 3-T MR Imaging for Malignant Liver Lesions by Using Ex Vivo MR Imaging-matched Pathologic Findings as the Reference Standard. Radiology. 2015 Sep; 276(3):775-86. Costa EA, Cunha GM, Smorodinsky E, Cruite I, Tang A, Marks RM, Clark L, Wolfson T, Gamst A, Sicklick JK, Hemming A, Peterson MR, Middleton MS, Sirlin CB. PMID: 25875972; PMCID: PMC4962530.
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    51. Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children. J Magn Reson Imaging. 2015 Nov; 42(5):1223-32. Zand KA, Shah A, Heba E, Wolfson T, Hamilton G, Lam J, Chen J, Hooker JC, Gamst AC, Middleton MS, Schwimmer JB, Sirlin CB. PMID: 25847512; PMCID: PMC4592685.
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    52. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease. Hepatology. 2015 Jun; 61(6):1887-95. Schwimmer JB, Middleton MS, Behling C, Newton KP, Awai HI, Paiz MN, Lam J, Hooker JC, Hamilton G, Fontanesi J, Sirlin CB. PMID: 25529941; PMCID: PMC4670559.
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    53. Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis. Abdom Imaging. 2015 Jan; 40(1):26-37. Tang A, Chen J, Le TA, Changchien C, Hamilton G, Middleton MS, Loomba R, Sirlin CB. PMID: 25015398; PMCID: PMC4293373.
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    54. Associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative diffusion-weighted MRI measurements in adults. J Magn Reson Imaging. 2015 Jun; 41(6):1629-38. Murphy P, Hooker J, Ang B, Wolfson T, Gamst A, Bydder M, Middleton M, Peterson M, Behling C, Loomba R, Sirlin C. PMID: 25256692; PMCID: PMC4819971.
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    55. Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease. Radiology. 2015 Feb; 274(2):416-25. Tang A, Desai A, Hamilton G, Wolfson T, Gamst A, Lam J, Clark L, Hooker J, Chavez T, Ang BD, Middleton MS, Peterson M, Loomba R, Sirlin CB. PMID: 25247408; PMCID: PMC4314291.
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    56. Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency. J Hepatol. 2014 Nov; 61(5):1135-42. Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG. PMID: 24993530; PMCID: PMC4203712.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    57. Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J Magn Reson Imaging. 2014 Jun; 39(6):1525-32. Bonekamp S, Tang A, Mashhood A, Wolfson T, Changchien C, Middleton MS, Clark L, Gamst A, Loomba R, Sirlin CB. PMID: 24987758; PMCID: PMC4083476.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    58. MR evaluation of breast implants. Radiol Clin North Am. 2014 May; 52(3):591-608. Middleton MS. PMID: 24792659.
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    59. Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects. J Magn Reson Imaging. 2014 May; 39(5):1265-71. Negrete LM, Middleton MS, Clark L, Wolfson T, Gamst AC, Lam J, Changchien C, Deyoung-Dominguez IM, Hamilton G, Loomba R, Schwimmer J, Sirlin CB. PMID: 24136736; PMCID: PMC3984359.
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    60. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner DA, Sirlin C, Loomba R. PMID: 23696515; PMCID: PMC4819962.
      View in: PubMed   Mentions: 227     Fields:    Translation:Humans
    61. Effect of echo-sampling strategy on the accuracy of out-of-phase and in-phase multiecho gradient-echo MRI hepatic fat fraction estimation. J Magn Reson Imaging. 2014 Mar; 39(3):567-75. Levin YS, Yokoo T, Wolfson T, Gamst AC, Collins J, Achmad EA, Hamilton G, Middleton MS, Loomba R, Sirlin CB. PMID: 23720420; PMCID: PMC3760998.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    62. Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data-based, T1-independent, T2*-corrected, spectrum-modeled MRI. J Magn Reson Imaging. 2014 Feb; 39(2):440-7. Johnson BL, Schroeder ME, Wolfson T, Gamst AC, Hamilton G, Shiehmorteza M, Loomba R, Schwimmer JB, Reeder S, Middleton MS, Sirlin CB. PMID: 23596052; PMCID: PMC3732566.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    63. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology. 2013 May; 267(2):422-31. Tang A, Tan J, Sun M, Hamilton G, Bydder M, Wolfson T, Gamst AC, Middleton M, Brunt EM, Loomba R, Lavine JE, Schwimmer JB, Sirlin CB. PMID: 23382291; PMCID: PMC3632805.
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    64. Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging. J Magn Reson Imaging. 2013 Jun; 37(6):1359-70. Mashhood A, Railkar R, Yokoo T, Levin Y, Clark L, Fox-Bosetti S, Middleton MS, Riek J, Kauh E, Dardzinski BJ, Williams D, Sirlin C, Shire NJ. PMID: 23172799.
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    65. Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. J Magn Reson Imaging. 2011 Oct; 34(4):928-34. Kang GH, Cruite I, Shiehmorteza M, Wolfson T, Gamst AC, Hamilton G, Bydder M, Middleton MS, Sirlin CB. PMID: 21769986; PMCID: PMC4803481.
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    66. Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. Radiology. 2011 Mar; 258(3):749-59. Yokoo T, Shiehmorteza M, Hamilton G, Wolfson T, Schroeder ME, Middleton MS, Bydder M, Gamst AC, Kono Y, Kuo A, Patton HM, Horgan S, Lavine JE, Schwimmer JB, Sirlin CB. PMID: 21212366; PMCID: PMC3042639.
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    67. In vivo characterization of the liver fat ¹H MR spectrum. NMR Biomed. 2011 Aug; 24(7):784-90. Hamilton G, Yokoo T, Bydder M, Cruite I, Schroeder ME, Sirlin CB, Middleton MS. PMID: 21834002; PMCID: PMC3860876.
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    68. Assessment of liver fat quantification in the presence of iron. Magn Reson Imaging. 2010 Jul; 28(6):767-76. Bydder M, Shiehmorteza M, Yokoo T, Sugay S, Middleton MS, Girard O, Schroeder ME, Wolfson T, Gamst A, Sirlin C. PMID: 20409663; PMCID: PMC2924146.
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    69. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology. 2010 Apr; 138(4):1357-64, 1364.e1-2. Schwimmer JB, Dunn W, Norman GJ, Pardee PE, Middleton MS, Kerkar N, Sirlin CB. PMID: 20064512; PMCID: PMC2846968.
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    70. Nephrogenic systemic fibrosis in liver disease: a systematic review. J Magn Reson Imaging. 2009 Dec; 30(6):1313-22. Mazhar SM, Shiehmorteza M, Kohl CA, Middleton MS, Sirlin CB. PMID: 19937937; PMCID: PMC2844250.
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    71. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging. 2009 Jul; 30(1):145-52. Hamilton G, Middleton MS, Bydder M, Yokoo T, Schwimmer JB, Kono Y, Patton HM, Lavine JE, Sirlin CB. PMID: 19557733; PMCID: PMC2982807.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCTClinical Trials
    72. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology. 2009 Apr; 251(1):67-76. Yokoo T, Bydder M, Hamilton G, Middleton MS, Gamst AC, Wolfson T, Hassanein T, Patton HM, Lavine JE, Schwimmer JB, Sirlin CB. PMID: 19221054; PMCID: PMC2663579.
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    73. Heritability of nonalcoholic fatty liver disease. Gastroenterology. 2009 May; 136(5):1585-92. Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, Shiehmorteza M, Yokoo T, Chavez A, Middleton MS, Sirlin CB. PMID: 19208353; PMCID: PMC3397140.
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    74. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics. 2009 Jan-Feb; 29(1):231-60. Cassidy FH, Yokoo T, Aganovic L, Hanna RF, Bydder M, Middleton MS, Hamilton G, Chavez AD, Schwimmer JB, Sirlin CB. PMID: 19168847.
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    75. Effects of intravenous gadolinium administration and flip angle on the assessment of liver fat signal fraction with opposed-phase and in-phase imaging. J Magn Reson Imaging. 2008 Jul; 28(1):246-51. Yokoo T, Collins JM, Hanna RF, Bydder M, Middleton MS, Sirlin CB. PMID: 18581393.
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    76. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging. 2008 Apr; 26(3):347-59. Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB. PMID: 18093781; PMCID: PMC2386876.
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    77. Can gadopentetate dimeglumine be safely administered more rapidly than the FDA-approved injection rate for liver imaging? AJR Am J Roentgenol. 2007 Oct; 189(4):W231. Shiehmorteza M, Hanna RF, Middleton MS. PMID: 17885038.
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    78. Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr. 2006 Oct; 43(4):413-27. Patton HM, Sirlin C, Behling C, Middleton M, Schwimmer JB, Lavine JE. PMID: 17033514.
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    79. The efficacy of breast MRI in predicting breast conservation therapy. J Surg Oncol. 2006 Sep 01; 94(3):220-5. Blair S, McElroy M, Middleton MS, Comstock C, Wolfson T, Kamrava M, Wallace A, Mortimer J. PMID: 16900536.
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    80. Students' perceptions of rewards for academic performance by parents and teachers: relations with achievement and motivation in college. J Genet Psychol. 2006 Jun; 167(2):211-20. Davis KD, Winsler A, Middleton M. PMID: 16910211.
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    81. Counterfactual thinking and quality of life among women with silicone breast implants. J Behav Med. 2002 Aug; 25(4):317-35. Parker PA, Middleton MS, Kulik JA. PMID: 12136495.
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    82. MR imaging of extracapsular silicone from breast implants: diagnostic pitfalls. AJR Am J Roentgenol. 2002 Feb; 178(2):465-72. Berg WA, Nguyen TK, Middleton MS, Soo MS, Pennello G, Brown SL. PMID: 11804919.
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