Xuchu Que

Title(s)Project Scientist, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0682
La Jolla CA 92093
Phone858-534-4407
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Circulation. 2021 12 14; 144(24):1940-1954. Dou H, Kotini A, Liu W, Fidler T, Endo Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR, Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR. PMID: 34846914; PMCID: PMC8663540.
      View in: PubMed   Mentions:
    2. Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell. 2021 08; 20(8):e13442. Palmieri M, Almeida M, Nookaew I, Gomez-Acevedo H, Joseph TE, Que X, Tsimikas S, Sun X, Manolagas SC, Witztum JL, Ambrogini E. PMID: 34278710; PMCID: PMC8373359.
      View in: PubMed   Mentions: 1     Fields:    
    3. A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice. J Bone Miner Res. 2021 01; 36(1):170-185. Palmieri M, Kim HN, Gomez-Acevedo H, Que X, Tsimikas S, Jilka RL, Manolagas SC, Witztum JL, Ambrogini E. PMID: 32990984; PMCID: PMC7855899.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in Ldlr-/- Mice. Antibodies (Basel). 2020 Jul 03; 9(3). Biswas TK, VanderLaan PA, Que X, Gonen A, Krishack P, Binder CJ, Witztum JL, Getz GS, Reardon CA. PMID: 32635160; PMCID: PMC7551411.
      View in: PubMed   Mentions: 1  
    5. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 01 07; 31(1):189-206.e8. Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566; PMCID: PMC7028360.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    6. Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 01 01; 115(1):179-189. Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. PMID: 29850765; PMCID: PMC6302283.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
      View in: PubMed   Mentions: 2     Fields:    
    8. Oxidation-specific epitopes restrain bone formation. Nat Commun. 2018 06 06; 9(1):2193. Ambrogini E, Que X, Wang S, Yamaguchi F, Weinstein RS, Tsimikas S, Manolagas SC, Witztum JL, Jilka RL. PMID: 29875355; PMCID: PMC5990540.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    9. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    10. Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 03 01; 200(5):1702-1717. Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum JL. PMID: 29378911; PMCID: PMC5821571.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol. 2018 01 23; 71(3):321-335. Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S. PMID: 29348025; PMCID: PMC5995462.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    12. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 01; 193(11):5637-48. Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. PMID: 25339664; PMCID: PMC4239162.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. J Lipid Res. 2014 Oct; 55(10):2137-55. Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. PMID: 25143462; PMCID: PMC4174006.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2771-9. Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum JL, Bender TP, McNamara CA. PMID: 24115031; PMCID: PMC4003558.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    15. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS One. 2013; 8(6):e65203. Que X, Widhopf GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. PMID: 23840319; PMCID: PMC3688726.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res. 2012 Jul; 53(7):1316-26. Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum JL, Binder CJ. PMID: 22508944; PMCID: PMC3371243.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    17. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 21252151; PMCID: PMC3075542.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimalsCells
    18. The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Mol Biochem Parasitol. 2009 Mar; 164(1):86-94. Huang R, Que X, Hirata K, Brinen LS, Lee JH, Hansell E, Engel J, Sajid M, Reed S. PMID: 19111576; PMCID: PMC2663568.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    19. Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii. J Biol Chem. 2007 Feb 16; 282(7):4994-5003. Que X, Engel JC, Ferguson D, Wunderlich A, Tomavo S, Reed SL. PMID: 17164247.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. PMID: 16987516.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis. Infect Immun. 2004 May; 72(5):2915-21. Que X, Wunderlich A, Joiner KA, Reed SL. PMID: 15102804; PMCID: PMC387868.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. PMID: 12595442; PMCID: PMC148873.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. J Biol Chem. 2002 Jul 12; 277(28):25791-7. Que X, Ngo H, Lawton J, Gray M, Liu Q, Engel J, Brinen L, Ghosh P, Joiner KA, Reed SL. PMID: 12000756.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    24. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan; 119(1):23-32. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. PMID: 11755183.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    25. Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S63-4. Brinen LS, Que X, McKerrow JH, Reed SL. PMID: 11070225.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Two genes encoding unique proliferating-cell-nuclear-antigens are expressed in Toxoplasma gondii. Mol Biochem Parasitol. 2000 Jul; 109(2):121-31. Guerini MN, Que X, Reed SL, White MW. PMID: 10960171.
      View in: PubMed   Mentions:
    27. L6: a proteinase- and phagocytosis-deficient mutant of Entamoeba histolytica. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S237-8. Carpeniseanu S, Hirata K, Que X, Orozco E, Reed SL. PMID: 11070298.
      View in: PubMed   Mentions:
    28. Cysteine proteinases and the pathogenesis of amebiasis. Clin Microbiol Rev. 2000 Apr; 13(2):196-206. Que X, Reed SL. PMID: 10755997; PMCID: PMC100150.
      View in: PubMed   Mentions:
    29. Pantropic retroviral vectors mediate gene transfer and expression in Entamoeba histolytica. Mol Biochem Parasitol. 1999 Apr 30; 99(2):237-45. Que X, Kim D, Alagon A, Hirata K, Shike H, Shimizu C, Gonzalez A, Burns JC, Reed SL. PMID: 10340487.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Cellular and transcriptional changes during excystation of Giardia lamblia in vitro. Exp Parasitol. 1998 Mar; 88(3):172-83. Hetsko ML, McCaffery JM, Svärd SG, Meng TC, Que X, Gillin FD. PMID: 9562420.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. The role of extracellular cysteine proteinases in pathogenesis of Entamoeba histolytica invasion. Parasitol Today. 1997 May; 13(5):190-4. Que X, Reed SL. PMID: 15275090.
      View in: PubMed   Mentions:
    32. Developmentally regulated transcripts and evidence of differential mRNA processing in Giardia lamblia. Mol Biochem Parasitol. 1996 Oct 18; 81(1):101-10. Que X, Svärd SG, Meng TC, Hetsko ML, Aley SB, Gillin FD. PMID: 8892309.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Expression and characterization of a rac family protein kinase of Entamoeba histolytica. Mol Biochem Parasitol. 1994 Jul; 66(1):111-8. Que X, Reed SL. PMID: 7984173.
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    34. Molecular cloning of a rac family protein kinase and identification of a serine/threonine protein kinase gene family of Entamoeba histolytica. Mol Biochem Parasitol. 1993 Aug; 60(2):161-70. Que X, Samuelson J, Reed S. PMID: 8232409.
      View in: PubMed   Mentions:
    35. Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. J Clin Invest. 1993 Apr; 91(4):1532-40. Reed S, Bouvier J, Pollack AS, Engel JC, Brown M, Hirata K, Que X, Eakin A, Hagblom P, Gillin F, et al. PMID: 8473498; PMCID: PMC288129.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. A unique cysteine proteinase gene of pathogenic Entamoeba histolytica correlates with virulence. Arch Med Res. 1992; 23(2):181-2. Reed S, Bouvier J, Hirata K, Que X, Pollack AS, Engel JC, Gillin F, McKerrow JH. PMID: 1340288.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. Nucleotide sequence of a small subunit ribosomal RNA (16S-like rRNA) gene from Entamoeba histolytica: differentiation of pathogenic from nonpathogenic isolates. Nucleic Acids Res. 1991 Oct 11; 19(19):5438. Que X, Reed SL. PMID: 1923831; PMCID: PMC328914.
      View in: PubMed   Mentions:
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