Loading...

Alan Saltiel

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0757
La Jolla CA 92093
Phone858-534-5953
Emailasaltiel@ucsd.edu
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of glycogen in health and disease
    NIH/NIDDK R01DK117551Jul 1, 2018 - May 31, 2022
    Role: Principal Investigator
    IKKepsilon/TBK1 Inhibitors for the Treatment of Obesity and Type 2 Diabetes
    NIH/NIDDK R01DK100319Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Probing the relevance of the "counter-inflammatory" noncanonical IkB kinases in r
    NIH/NIDDK R21DK098776Sep 18, 2013 - Jul 31, 2015
    Role: Principal Investigator
    The Role of the Exocyst Complex in Insulin Regulated Glucose Transport
    NIH/NIDDK R01DK076906Dec 1, 2006 - May 31, 2020
    Role: Principal Investigator
    The Role of G Proteins in Insulin Action
    NIH/NIDDK R01DK061618May 15, 2002 - Jun 30, 2017
    Role: Principal Investigator
    Hormonal Regulation of Glycogen Synthesis
    NIH/NIDDK R01DK060597Feb 15, 2002 - Jan 31, 2012
    Role: Principal Investigator
    Signaling Pathways in Insulin Action
    NIH/NIDDK R01DK060591Feb 1, 2002 - Aug 31, 2017
    Role: Principal Investigator
    DETERMINANTS OF SPECIFICITY IN SIGNAL TRANSDUCTION
    NIH/NIDDK R13DK053164Apr 1, 1997 - Mar 31, 1998
    Role: Principal Investigator
    TRAINING PROGRAM IN DIABETES RESEARCH
    NIH/NIDDK T32DK007494Jul 1, 1984 - Aug 31, 2022
    Role: Co-Principal Investigator
    MOLECULAR MECHANISMS OF INSULIN ACTION
    NIH/NIDDK R01DK033804Jul 1, 1984 - Jun 30, 1992
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INSULIN ACTION
    NIH/NIADDK R23AM033804Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INSULIN ACTION
    NIH/NIDDK R23DK033804Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKe for the treatment of obesity. Bioorg Med Chem. 2018 Sep 20. PMID: 30270002.
      View in: PubMed
    2. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 Sep 20; 175(1):133-145.e15. PMID: 30220454.
      View in: PubMed
    3. Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJ. Carboxylic acid derivatives of amlexanox display enhanced potency towards TBK1 and IKK? and reveal mechanisms for selective inhibition. Mol Pharmacol. 2018 Aug 06. PMID: 30082428.
      View in: PubMed
    4. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 Jun 18. PMID: 29915037.
      View in: PubMed
    5. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. ERR? Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 Mar 13; 22(11):2849-2859. PMID: 29539415.
      View in: PubMed
    6. Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018 Feb 08; 172(4):731-743.e12. PMID: 29425491.
      View in: PubMed
    7. Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH. Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation. Hepatology. 2017 Dec 18. PMID: 29251796.
      View in: PubMed
    8. Ichikawa T, Kita M, Matsui TS, Nagasato AI, Araki T, Chiang SH, Sezaki T, Kimura Y, Ueda K, Deguchi S, Saltiel AR, Kioka N. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017 Oct 15; 130(20):3517-3531. PMID: 28864765.
      View in: PubMed
    9. Saltiel AR. Creatine Fuels the Thermic Effect of Feeding. Cell Metab. 2017 Oct 03; 26(4):594-595. PMID: 28844879.
      View in: PubMed
    10. Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11):633-643. PMID: 28799554.
      View in: PubMed
    11. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. PMID: 28683283.
      View in: PubMed
    12. Uhm M, Bazuine M, Zhao P, Chiang SH, Xiong T, Karunanithi S, Chang L, Saltiel AR. Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking. Sci Signal. 2017 Mar 21; 10(471). PMID: 28325821.
      View in: PubMed
    13. Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 Jan 03; 127(1):1-4. PMID: 28045402.
      View in: PubMed
    14. Saltiel AR. New therapeutic approaches for the treatment of obesity. Sci Transl Med. 2016 Jan 27; 8(323):323rv2. PMID: 26819198.
      View in: PubMed
    15. Saltiel AR. Insulin Signaling in the Control of Glucose and Lipid Homeostasis. Handb Exp Pharmacol. 2016; 233:51-71. PMID: 26721672.
      View in: PubMed
    16. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
    17. Maillard I, Saltiel AR. Metabolism: Inflammation keeps old mice healthy. Nature. 2015 Dec 03; 528(7580):44-6. PMID: 26580010.
      View in: PubMed
    18. Reilly SM, Saltiel AR. A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. PMID: 26496598.
      View in: PubMed
    19. Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, Saltiel AR, Vendrell J, Fernández-Veledo S. Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans. Mol Metab. 2016 Jan; 5(1):5-18. PMID: 26844203; PMCID: PMC4703799.
    20. Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D. Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. J Mol Endocrinol. 2015 Oct; 55(2):81-94. PMID: 26150553; PMCID: PMC4543687.
    21. Hochberg I, Tran QT, Barkan AL, Saltiel AR, Chandler WF, Bridges D. Gene Expression Signature in Adipose Tissue of Acromegaly Patients. PLoS One. 2015; 10(6):e0129359. PMID: 26087292; PMCID: PMC4472931.
    22. Uhm M, Saltiel AR. White, brown, and beige; type 2 immunity gets hot. Immunity. 2015 Jan 20; 42(1):15-7. PMID: 25607455.
      View in: PubMed
    23. Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR. Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. J Biol Chem. 2015 Mar 06; 290(10):6376-86. PMID: 25596527; PMCID: PMC4358273.
    24. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. PMID: 25581158; PMCID: PMC4324568.
    25. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344; PMCID: PMC4320010.
    26. Bridges D, Saltiel AR. Phosphoinositides: Key modulators of energy metabolism. Biochim Biophys Acta. 2015 Jun; 1851(6):857-66. PMID: 25463477; PMCID: PMC4975561.
    27. Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen XW, Saltiel AR. A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Mol Biol Cell. 2014 Oct 01; 25(19):3059-69. PMID: 25103239; PMCID: PMC4230594.
    28. Morrow AA, Alipour MA, Bridges D, Yao Z, Saltiel AR, Lee JM. The lipid kinase PI4KIIIß is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Mol Cancer Res. 2014 Oct; 12(10):1492-508. PMID: 24962317.
      View in: PubMed
    29. Reilly SM, Saltiel AR. Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. PMID: 24747704.
      View in: PubMed
    30. Liu S, Xu R, Gerin I, Cawthorn WP, Macdougald OA, Chen XW, Saltiel AR, Koenig RJ, Xu B. SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling. PLoS One. 2014; 9(4):e95416. PMID: 24743795; PMCID: PMC3990642.
    31. Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel AR. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes. 2014 Sep; 63(9):2935-48. PMID: 24722244; PMCID: PMC4141363.
    32. Reilly SM, Saltiel AR. Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. PMID: 24492182.
      View in: PubMed
    33. Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell. 2014 Apr; 25(7):1171-85. PMID: 24478451; PMCID: PMC3967979.
    34. Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23; 53(2):209-20. PMID: 24389102; PMCID: PMC3955741.
    35. Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD. Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 2014 Apr; 63(4):1340-52. PMID: 24379350; PMCID: PMC3964504.
    36. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1. Elife. 2013 Dec 24; 2:e01119. PMID: 24368730; PMCID: PMC3869376.
    37. Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K. Inhibition of AMPK catabolic action by GSK3. Mol Cell. 2013 May 09; 50(3):407-19. PMID: 23623684; PMCID: PMC3654099.
    38. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. PMID: 23396211; PMCID: PMC3594079.
    39. Leto D, Uhm M, Williams A, Chen XW, Saltiel AR. Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem. 2013 Mar 29; 288(13):9272-83. PMID: 23386617; PMCID: PMC3610998.
    40. Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17472-7. PMID: 23047693; PMCID: PMC3491506.
    41. Bridges D, Chang L, Lodhi IJ, Clark NA, Saltiel AR. TC10 is regulated by caveolin in 3T3-L1 adipocytes. PLoS One. 2012; 7(8):e42451. PMID: 22900022; PMCID: PMC3416860.
    42. Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel AR. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell. 2012 Aug; 23(15):2955-62. PMID: 22696681; PMCID: PMC3408421.
    43. Saltiel AR. Insulin resistance in the defense against obesity. Cell Metab. 2012 Jun 06; 15(6):798-804. PMID: 22682220.
      View in: PubMed
    44. Leto D, Saltiel AR. Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol. 2012 May 23; 13(6):383-96. PMID: 22617471.
      View in: PubMed
    45. Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel AR. Rab5 proteins regulate activation and localization of target of rapamycin complex 1. J Biol Chem. 2012 Jun 15; 287(25):20913-21. PMID: 22547071; PMCID: PMC3375515.
    46. Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5838-43. PMID: 22460790; PMCID: PMC3326459.
    47. Klionsky DJ, Saltiel AR. Autophagy works out. Cell Metab. 2012 Mar 07; 15(3):273-4. PMID: 22405064; PMCID: PMC3308187.
    48. Bridges D, Saltiel AR. Phosphoinositides in insulin action and diabetes. Curr Top Microbiol Immunol. 2012; 362:61-85. PMID: 23086413.
      View in: PubMed
    49. Saltiel AR. Derepressing nuclear receptors for metabolic adaptation. Cell. 2011 Nov 11; 147(4):717-8. PMID: 22078871.
      View in: PubMed
    50. Li S, Chen XW, Yu L, Saltiel AR, Lin JD. Circadian metabolic regulation through crosstalk between casein kinase 1d and transcriptional coactivator PGC-1a. Mol Endocrinol. 2011 Dec; 25(12):2084-93. PMID: 22052997; PMCID: PMC3231836.
    51. Chen XW, Saltiel AR. Ral's engagement with the exocyst: breaking up is hard to do. Cell Cycle. 2011 Jul 15; 10(14):2299-304. PMID: 21654196.
      View in: PubMed
    52. Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011 Jun; 121(6):2111-7. PMID: 21633179; PMCID: PMC3104776.
    53. Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong T, Yu G, Ginsburg D, Toomre D, Xu Z, Saltiel AR. Exocyst function is regulated by effector phosphorylation. Nat Cell Biol. 2011 May; 13(5):580-8. PMID: 21516108; PMCID: PMC3904505.
    54. Chen XW, Leto D, Xiong T, Yu G, Cheng A, Decker S, Saltiel AR. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell. 2011 Jan 01; 22(1):141-52. PMID: 21148297; PMCID: PMC3016972.
    55. Saltiel AR. Fishing out a sensor for anti-inflammatory oils. Cell. 2010 Sep 03; 142(5):672-4. PMID: 20813253.
      View in: PubMed
    56. Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel AR, Lumeng CN. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med. 2009 Dec 21; 206(13):3143-56. PMID: 19995956; PMCID: PMC2806469.
    57. Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 2009 Sep 04; 138(5):961-75. PMID: 19737522; PMCID: PMC2756060.
    58. Lumeng CN, Maillard I, Saltiel AR. T-ing up inflammation in fat. Nat Med. 2009 Aug; 15(8):846-7. PMID: 19661987.
      View in: PubMed
    59. Xiao J, Chen XW, Davies BA, Saltiel AR, Katzmann DJ, Xu Z. Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell. 2009 Aug; 20(15):3514-24. PMID: 19477918; PMCID: PMC2719569.
    60. Cheng A, Zhang M, Okubo M, Omichi K, Saltiel AR. Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions. Hum Mol Genet. 2009 Jun 01; 18(11):2045-52. PMID: 19299494; PMCID: PMC2678930.
    61. Cheng A, Saltiel AR. Von Gierke's disease adopts an orphan (and its partner). Sci Signal. 2009 Feb 17; 2(58):pe8. PMID: 19224896.
      View in: PubMed
    62. Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA, Smith Y, Warmus JS, Tecle H. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6501-4. PMID: 18952427.
      View in: PubMed
    63. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008 Dec; 57(12):3239-46. PMID: 18829989; PMCID: PMC2584129.
    64. Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR. Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell. 2008 Jul; 19(7):2718-28. PMID: 18434594; PMCID: PMC2441665.
    65. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. PMID: 17908927; PMCID: PMC1993871.
    66. Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel AR. Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell. 2007 Dec; 18(12):4731-40. PMID: 17898075; PMCID: PMC2096606.
    67. Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR. Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell. 2007 Sep; 13(3):391-404. PMID: 17765682.
      View in: PubMed
    68. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. PMID: 17351624.
      View in: PubMed
    69. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007 Jan; 56(1):16-23. PMID: 17192460.
      View in: PubMed
    70. Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 2007 Jan; 5(1):59-72. PMID: 17189207; PMCID: PMC1779820.
    71. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007 Jan; 117(1):175-84. PMID: 17200717; PMCID: PMC1716210.
    72. Chen XW, Saltiel AR. TIRFing out studies on Glut4 trafficking. Dev Cell. 2007 Jan; 12(1):4-5. PMID: 17199036.
      View in: PubMed
    73. Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel AR. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006 Nov 15; 25(22):5284-93. PMID: 17082770; PMCID: PMC1636617.
    74. Chen XW, Inoue M, Hsu SC, Saltiel AR. RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis. J Biol Chem. 2006 Dec 15; 281(50):38609-16. PMID: 17028198.
      View in: PubMed
    75. Chang L, Chiang SH, Saltiel AR. TC10alpha is required for insulin-stimulated glucose uptake in adipocytes. Endocrinology. 2007 Jan; 148(1):27-33. PMID: 17008399.
      View in: PubMed
    76. Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, Matsuda M. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell. 2006 Sep; 11(3):411-21. PMID: 16950130.
      View in: PubMed
    77. Lumeng CN, Deyoung SM, Saltiel AR. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E166-74. PMID: 16926380; PMCID: PMC3888778.
    78. Su X, Lodhi IJ, Saltiel AR, Stahl PD. Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem. 2006 Sep 22; 281(38):27982-90. PMID: 16880210.
      View in: PubMed
    79. Lumeng CN, Saltiel AR. Insulin htts on autophagy. Autophagy. 2006 Jul-Sep; 2(3):250-3. PMID: 16874093.
      View in: PubMed
    80. Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell. 2006 May 05; 125(3):577-91. PMID: 16678100.
      View in: PubMed
    81. Cheng A, Zhang M, Crosson SM, Bao ZQ, Saltiel AR. Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells. Endocrinology. 2006 Jul; 147(7):3606-12. PMID: 16627590.
      View in: PubMed
    82. Lazar DF, Saltiel AR. Lipid phosphatases as drug discovery targets for type 2 diabetes. Nat Rev Drug Discov. 2006 Apr; 5(4):333-42. PMID: 16582877.
      View in: PubMed
    83. Inoue M, Chiang SH, Chang L, Chen XW, Saltiel AR. Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell. 2006 May; 17(5):2303-11. PMID: 16525015; PMCID: PMC1446102.
    84. Cheng A, Saltiel AR. More TORC for the gluconeogenic engine. Bioessays. 2006 Mar; 28(3):231-4. PMID: 16479585.
      View in: PubMed
    85. Chiang SH, Chang L, Saltiel AR. TC10 and insulin-stimulated glucose transport. Methods Enzymol. 2006; 406:701-14. PMID: 16472699.
      View in: PubMed
    86. Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, Saltiel AR. Changes in integrin expression during adipocyte differentiation. Cell Metab. 2005 Sep; 2(3):165-77. PMID: 16154099.
      View in: PubMed
    87. Saltiel AR. Holding the line on hepatic fat. Cell Metab. 2005 Jul; 2(1):1-2. PMID: 16054091.
      View in: PubMed
    88. Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel AR. The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem. 2005 Apr 22; 280(16):16125-34. PMID: 15713660.
      View in: PubMed
    89. Decker SJ, Saltiel AR. Staying in SHIP shape. Nat Med. 2005 Feb; 11(2):123-4. PMID: 15692594.
      View in: PubMed
    90. Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel AR, Sellke FW. Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Circulation. 2004 Sep 14; 110(11 Suppl 1):II280-6. PMID: 15364876.
      View in: PubMed
    91. Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regulation of glucose transport. Mol Med. 2004 Jul-Dec; 10(7-12):65-71. PMID: 16307172; PMCID: PMC1431367.
    92. Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE. Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol. 2004 Jan 19; 164(2):279-90. PMID: 14734537; PMCID: PMC2172328.
    93. Saltiel AR. Putting the brakes on insulin signaling. N Engl J Med. 2003 Dec 25; 349(26):2560-2. PMID: 14695419.
      View in: PubMed
    94. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell. 2003 Dec; 12(6):1379-89. PMID: 14690593.
      View in: PubMed
    95. Saltiel AR, Pessin JE. Insulin signaling in microdomains of the plasma membrane. Traffic. 2003 Nov; 4(11):711-6. PMID: 14617354.
      View in: PubMed
    96. Saltiel AR. A TUG on glucose transport. Nat Med. 2003 Nov; 9(11):1352. PMID: 14595425.
      View in: PubMed
    97. Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003 Sep 19; 278(38):36754-62. PMID: 12842890.
      View in: PubMed
    98. Chiang SH, Hwang J, Legendre M, Zhang M, Kimura A, Saltiel AR. TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003 Jun 02; 22(11):2679-91. PMID: 12773384; PMCID: PMC156759.
    99. Crosson SM, Khan A, Printen J, Pessin JE, Saltiel AR. PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest. 2003 May; 111(9):1423-32. PMID: 12727934; PMCID: PMC154451.
    100. Saltiel AR. Muscle or fat? Rho bridges the GAP. Cell. 2003 Apr 18; 113(2):144-5. PMID: 12705863.
      View in: PubMed
    101. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature. 2003 Apr 10; 422(6932):629-33. PMID: 12687004.
      View in: PubMed
    102. Watson RT, Furukawa M, Chiang SH, Boeglin D, Kanzaki M, Saltiel AR, Pessin JE. The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Mol Cell Biol. 2003 Feb; 23(3):961-74. PMID: 12529401; PMCID: PMC140699.
    103. Zhang M, Kimura A, Saltiel AR. Cloning and characterization of Cbl-associated protein splicing isoforms. Mol Med. 2003 Jan-Feb; 9(1-2):18-25. PMID: 12765336; PMCID: PMC1430382.
    104. Chang L, Adams RD, Saltiel AR. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12835-40. PMID: 12242347; PMCID: PMC130546.
    105. Kanzaki M, Watson RT, Hou JC, Stamnes M, Saltiel AR, Pessin JE. Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. Mol Biol Cell. 2002 Jul; 13(7):2334-46. PMID: 12134073; PMCID: PMC117317.
    106. Liu J, Kimura A, Baumann CA, Saltiel AR. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol. 2002 Jun; 22(11):3599-609. PMID: 11997497; PMCID: PMC133825.
    107. Kimura A, Mora S, Shigematsu S, Pessin JE, Saltiel AR. The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. J Biol Chem. 2002 Aug 16; 277(33):30153-8. PMID: 12036959.
      View in: PubMed
    108. Saltiel AR, Pessin JE. Insulin signaling pathways in time and space. Trends Cell Biol. 2002 Feb; 12(2):65-71. PMID: 11849969.
      View in: PubMed
    109. Chiang SH, Hou JC, Hwang J, Pessin JE, Saltiel AR. Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J Biol Chem. 2002 Apr 12; 277(15):13067-73. PMID: 11821390.
      View in: PubMed