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Alan Saltiel

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0757
La Jolla CA 92093
Phone858-534-5953
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    Collapse Research 
    Collapse Research Activities and Funding
    IKKepsilon/TBK1 Inhibitors for the Treatment of Obesity and Type 2 Diabetes
    NIH/NIDDK R01DK100319Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Probing the relevance of the "counter-inflammatory" noncanonical IkB kinases in r
    NIH/NIDDK R21DK098776Sep 18, 2013 - Jul 31, 2015
    Role: Principal Investigator
    The Role of the Exocyst Complex in Insulin Regulated Glucose Transport
    NIH/NIDDK R01DK076906Dec 1, 2006 - May 31, 2020
    Role: Principal Investigator
    The Role of G Proteins in Insulin Action
    NIH/NIDDK R01DK061618May 15, 2002 - Jun 30, 2017
    Role: Principal Investigator
    Hormonal Regulation of Glycogen Synthesis
    NIH/NIDDK R01DK060597Feb 15, 2002 - Jan 31, 2012
    Role: Principal Investigator
    Signaling Pathways in Insulin Action
    NIH/NIDDK R01DK060591Feb 1, 2002 - Aug 31, 2017
    Role: Principal Investigator
    DETERMINANTS OF SPECIFICITY IN SIGNAL TRANSDUCTION
    NIH/NIDDK R13DK053164Apr 1, 1997 - Mar 31, 1998
    Role: Principal Investigator
    TRAINING PROGRAM IN DIABETES RESEARCH
    NIH/NIDDK T32DK007494Jul 1, 1984 - Aug 31, 2022
    Role: Co-Principal Investigator
    MOLECULAR MECHANISMS OF INSULIN ACTION
    NIH/NIDDK R01DK033804Jul 1, 1984 - Jun 30, 1992
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INSULIN ACTION
    NIH/NIADDK R23AM033804Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INSULIN ACTION
    NIH/NIDDK R23DK033804Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel A, Downes M, Evans RM. ERR? Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 Mar 13; 22(11):2849-2859. PMID: 29539415.
      View in: PubMed
    2. Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel A. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018 Feb 08; 172(4):731-743.e12. PMID: 29425491.
      View in: PubMed
    3. Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel A, Lee JH. Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation. Hepatology. 2017 Dec 18. PMID: 29251796.
      View in: PubMed
    4. Ichikawa T, Kita M, Matsui TS, Nagasato AI, Araki T, Chiang SH, Sezaki T, Kimura Y, Ueda K, Deguchi S, Saltiel A, Kioka N. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017 Oct 15; 130(20):3517-3531. PMID: 28864765.
      View in: PubMed
    5. Saltiel A. Creatine Fuels the Thermic Effect of Feeding. Cell Metab. 2017 Oct 03; 26(4):594-595. PMID: 28844879.
      View in: PubMed
    6. Reilly SM, Saltiel A. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11):633-643. PMID: 28799554.
      View in: PubMed
    7. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel A. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. PMID: 28683283.
      View in: PubMed
    8. Uhm M, Bazuine M, Zhao P, Chiang SH, Xiong T, Karunanithi S, Chang L, Saltiel A. Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking. Sci Signal. 2017 Mar 21; 10(471). PMID: 28325821.
      View in: PubMed
    9. Saltiel A, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 Jan 03; 127(1):1-4. PMID: 28045402.
      View in: PubMed
    10. Saltiel A. New therapeutic approaches for the treatment of obesity. Sci Transl Med. 2016 Jan 27; 8(323):323rv2. PMID: 26819198.
      View in: PubMed
    11. Saltiel A. Insulin Signaling in the Control of Glucose and Lipid Homeostasis. Handb Exp Pharmacol. 2016; 233:51-71. PMID: 26721672.
      View in: PubMed
    12. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel A, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
    13. Maillard I, Saltiel A. Metabolism: Inflammation keeps old mice healthy. Nature. 2015 Dec 03; 528(7580):44-6. PMID: 26580010.
      View in: PubMed
    14. Reilly SM, Saltiel A. A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. PMID: 26496598.
      View in: PubMed
    15. Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, Saltiel A, Vendrell J, Fernández-Veledo S. Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans. Mol Metab. 2016 Jan; 5(1):5-18. PMID: 26844203; PMCID: PMC4703799.
    16. Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel A, Chandler WF, Bridges D. Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. J Mol Endocrinol. 2015 Oct; 55(2):81-94. PMID: 26150553; PMCID: PMC4543687.
    17. Hochberg I, Tran QT, Barkan AL, Saltiel A, Chandler WF, Bridges D. Gene Expression Signature in Adipose Tissue of Acromegaly Patients. PLoS One. 2015; 10(6):e0129359. PMID: 26087292; PMCID: PMC4472931.
    18. Uhm M, Saltiel A. White, brown, and beige; type 2 immunity gets hot. Immunity. 2015 Jan 20; 42(1):15-7. PMID: 25607455.
      View in: PubMed
    19. Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel A. Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. J Biol Chem. 2015 Mar 06; 290(10):6376-86. PMID: 25596527; PMCID: PMC4358273.
    20. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel A. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. PMID: 25581158; PMCID: PMC4324568.
    21. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel A, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344; PMCID: PMC4320010.
    22. Bridges D, Saltiel A. Phosphoinositides: Key modulators of energy metabolism. Biochim Biophys Acta. 2015 Jun; 1851(6):857-66. PMID: 25463477; PMCID: PMC4975561.
    23. Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen XW, Saltiel A. A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Mol Biol Cell. 2014 Oct 01; 25(19):3059-69. PMID: 25103239; PMCID: PMC4230594.
    24. Morrow AA, Alipour MA, Bridges D, Yao Z, Saltiel A, Lee JM. The lipid kinase PI4KIIIß is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Mol Cancer Res. 2014 Oct; 12(10):1492-508. PMID: 24962317.
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    25. Reilly SM, Saltiel A. Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. PMID: 24747704.
      View in: PubMed
    26. Liu S, Xu R, Gerin I, Cawthorn WP, Macdougald OA, Chen XW, Saltiel A, Koenig RJ, Xu B. SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling. PLoS One. 2014; 9(4):e95416. PMID: 24743795; PMCID: PMC3990642.
    27. Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel A. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes. 2014 Sep; 63(9):2935-48. PMID: 24722244; PMCID: PMC4141363.
    28. Reilly SM, Saltiel A. Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. PMID: 24492182.
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    29. Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel A, Klionsky DJ, Weisman LS. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell. 2014 Apr; 25(7):1171-85. PMID: 24478451; PMCID: PMC3967979.
    30. Martin TD, Chen XW, Kaplan RE, Saltiel A, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23; 53(2):209-20. PMID: 24389102; PMCID: PMC3955741.
    31. Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel A, Lumeng CN, Lin JD. Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 2014 Apr; 63(4):1340-52. PMID: 24379350; PMCID: PMC3964504.
    32. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel A. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1. Elife. 2013 Dec 24; 2:e01119. PMID: 24368730; PMCID: PMC3869376.
    33. Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel A, Inoki K. Inhibition of AMPK catabolic action by GSK3. Mol Cell. 2013 May 09; 50(3):407-19. PMID: 23623684; PMCID: PMC3654099.
    34. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel A. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. PMID: 23396211; PMCID: PMC3594079.
    35. Leto D, Uhm M, Williams A, Chen XW, Saltiel A. Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem. 2013 Mar 29; 288(13):9272-83. PMID: 23386617; PMCID: PMC3610998.
    36. Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel A, Meisler MH, Russell MW, Weisman LS. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17472-7. PMID: 23047693; PMCID: PMC3491506.
    37. Bridges D, Chang L, Lodhi IJ, Clark NA, Saltiel A. TC10 is regulated by caveolin in 3T3-L1 adipocytes. PLoS One. 2012; 7(8):e42451. PMID: 22900022; PMCID: PMC3416860.
    38. Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel A. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell. 2012 Aug; 23(15):2955-62. PMID: 22696681; PMCID: PMC3408421.
    39. Saltiel A. Insulin resistance in the defense against obesity. Cell Metab. 2012 Jun 06; 15(6):798-804. PMID: 22682220.
      View in: PubMed
    40. Leto D, Saltiel A. Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol. 2012 May 23; 13(6):383-96. PMID: 22617471.
      View in: PubMed
    41. Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel A. Rab5 proteins regulate activation and localization of target of rapamycin complex 1. J Biol Chem. 2012 Jun 15; 287(25):20913-21. PMID: 22547071; PMCID: PMC3375515.
    42. Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel A, Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5838-43. PMID: 22460790; PMCID: PMC3326459.
    43. Klionsky DJ, Saltiel A. Autophagy works out. Cell Metab. 2012 Mar 07; 15(3):273-4. PMID: 22405064; PMCID: PMC3308187.
    44. Bridges D, Saltiel A. Phosphoinositides in insulin action and diabetes. Curr Top Microbiol Immunol. 2012; 362:61-85. PMID: 23086413.
      View in: PubMed
    45. Saltiel A. Derepressing nuclear receptors for metabolic adaptation. Cell. 2011 Nov 11; 147(4):717-8. PMID: 22078871.
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    46. Li S, Chen XW, Yu L, Saltiel A, Lin JD. Circadian metabolic regulation through crosstalk between casein kinase 1d and transcriptional coactivator PGC-1a. Mol Endocrinol. 2011 Dec; 25(12):2084-93. PMID: 22052997; PMCID: PMC3231836.
    47. Chen XW, Saltiel A. Ral's engagement with the exocyst: breaking up is hard to do. Cell Cycle. 2011 Jul 15; 10(14):2299-304. PMID: 21654196.
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    48. Lumeng CN, Saltiel A. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011 Jun; 121(6):2111-7. PMID: 21633179; PMCID: PMC3104776.
    49. Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong T, Yu G, Ginsburg D, Toomre D, Xu Z, Saltiel A. Exocyst function is regulated by effector phosphorylation. Nat Cell Biol. 2011 May; 13(5):580-8. PMID: 21516108; PMCID: PMC3904505.
    50. Chen XW, Leto D, Xiong T, Yu G, Cheng A, Decker S, Saltiel A. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell. 2011 Jan 01; 22(1):141-52. PMID: 21148297; PMCID: PMC3016972.
    51. Saltiel A. Fishing out a sensor for anti-inflammatory oils. Cell. 2010 Sep 03; 142(5):672-4. PMID: 20813253.
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    52. Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel A, Lumeng CN. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med. 2009 Dec 21; 206(13):3143-56. PMID: 19995956; PMCID: PMC2806469.
    53. Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel A. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 2009 Sep 04; 138(5):961-75. PMID: 19737522; PMCID: PMC2756060.
    54. Lumeng CN, Maillard I, Saltiel A. T-ing up inflammation in fat. Nat Med. 2009 Aug; 15(8):846-7. PMID: 19661987.
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    55. Xiao J, Chen XW, Davies BA, Saltiel A, Katzmann DJ, Xu Z. Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell. 2009 Aug; 20(15):3514-24. PMID: 19477918; PMCID: PMC2719569.
    56. Cheng A, Zhang M, Okubo M, Omichi K, Saltiel A. Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions. Hum Mol Genet. 2009 Jun 01; 18(11):2045-52. PMID: 19299494; PMCID: PMC2678930.
    57. Cheng A, Saltiel A. Von Gierke's disease adopts an orphan (and its partner). Sci Signal. 2009 Feb 17; 2(58):pe8. PMID: 19224896.
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    58. Barrett SD, Bridges AJ, Dudley DT, Saltiel A, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA, Smith Y, Warmus JS, Tecle H. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6501-4. PMID: 18952427.
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    59. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel A. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008 Dec; 57(12):3239-46. PMID: 18829989; PMCID: PMC2584129.
    60. Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel A. Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell. 2008 Jul; 19(7):2718-28. PMID: 18434594; PMCID: PMC2441665.
    61. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel A. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. PMID: 17908927; PMCID: PMC1993871.
    62. Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel A. Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell. 2007 Dec; 18(12):4731-40. PMID: 17898075; PMCID: PMC2096606.
    63. Chen XW, Leto D, Chiang SH, Wang Q, Saltiel A. Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell. 2007 Sep; 13(3):391-404. PMID: 17765682.
      View in: PubMed
    64. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel A, Olefsky JM. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. PMID: 17351624.
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    65. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel A. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007 Jan; 56(1):16-23. PMID: 17192460.
      View in: PubMed
    66. Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel A. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 2007 Jan; 5(1):59-72. PMID: 17189207; PMCID: PMC1779820.
    67. Lumeng CN, Bodzin JL, Saltiel A. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007 Jan; 117(1):175-84. PMID: 17200717; PMCID: PMC1716210.
    68. Chen XW, Saltiel A. TIRFing out studies on Glut4 trafficking. Dev Cell. 2007 Jan; 12(1):4-5. PMID: 17199036.
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    69. Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel A. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006 Nov 15; 25(22):5284-93. PMID: 17082770; PMCID: PMC1636617.
    70. Chen XW, Inoue M, Hsu SC, Saltiel A. RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis. J Biol Chem. 2006 Dec 15; 281(50):38609-16. PMID: 17028198.
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    71. Chang L, Chiang SH, Saltiel A. TC10alpha is required for insulin-stimulated glucose uptake in adipocytes. Endocrinology. 2007 Jan; 148(1):27-33. PMID: 17008399.
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    72. Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel A, Matsuda M. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell. 2006 Sep; 11(3):411-21. PMID: 16950130.
      View in: PubMed
    73. Lumeng CN, Deyoung SM, Saltiel A. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E166-74. PMID: 16926380; PMCID: PMC3888778.
    74. Su X, Lodhi IJ, Saltiel A, Stahl PD. Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem. 2006 Sep 22; 281(38):27982-90. PMID: 16880210.
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    75. Lumeng CN, Saltiel A. Insulin htts on autophagy. Autophagy. 2006 Jul-Sep; 2(3):250-3. PMID: 16874093.
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    76. Chun TH, Hotary KB, Sabeh F, Saltiel A, Allen ED, Weiss SJ. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell. 2006 May 05; 125(3):577-91. PMID: 16678100.
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    77. Cheng A, Zhang M, Crosson SM, Bao ZQ, Saltiel A. Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells. Endocrinology. 2006 Jul; 147(7):3606-12. PMID: 16627590.
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    78. Lazar DF, Saltiel A. Lipid phosphatases as drug discovery targets for type 2 diabetes. Nat Rev Drug Discov. 2006 Apr; 5(4):333-42. PMID: 16582877.
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    79. Inoue M, Chiang SH, Chang L, Chen XW, Saltiel A. Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell. 2006 May; 17(5):2303-11. PMID: 16525015; PMCID: PMC1446102.
    80. Cheng A, Saltiel A. More TORC for the gluconeogenic engine. Bioessays. 2006 Mar; 28(3):231-4. PMID: 16479585.
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    81. Chiang SH, Chang L, Saltiel A. TC10 and insulin-stimulated glucose transport. Methods Enzymol. 2006; 406:701-14. PMID: 16472699.
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    82. Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, Saltiel A. Changes in integrin expression during adipocyte differentiation. Cell Metab. 2005 Sep; 2(3):165-77. PMID: 16154099.
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    83. Saltiel A. Holding the line on hepatic fat. Cell Metab. 2005 Jul; 2(1):1-2. PMID: 16054091.
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    84. Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel A. The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem. 2005 Apr 22; 280(16):16125-34. PMID: 15713660.
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    85. Decker SJ, Saltiel A. Staying in SHIP shape. Nat Med. 2005 Feb; 11(2):123-4. PMID: 15692594.
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    86. Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel A, Sellke FW. Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Circulation. 2004 Sep 14; 110(11 Suppl 1):II280-6. PMID: 15364876.
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    87. Chang L, Chiang SH, Saltiel A. Insulin signaling and the regulation of glucose transport. Mol Med. 2004 Jul-Dec; 10(7-12):65-71. PMID: 16307172; PMCID: PMC1431367.
    88. Kanzaki M, Mora S, Hwang JB, Saltiel A, Pessin JE. Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol. 2004 Jan 19; 164(2):279-90. PMID: 14734537; PMCID: PMC2172328.
    89. Saltiel A. Putting the brakes on insulin signaling. N Engl J Med. 2003 Dec 25; 349(26):2560-2. PMID: 14695419.
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    90. Hu J, Liu J, Ghirlando R, Saltiel A, Hubbard SR. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell. 2003 Dec; 12(6):1379-89. PMID: 14690593.
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    91. Saltiel A, Pessin JE. Insulin signaling in microdomains of the plasma membrane. Traffic. 2003 Nov; 4(11):711-6. PMID: 14617354.
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    92. Saltiel A. A TUG on glucose transport. Nat Med. 2003 Nov; 9(11):1352. PMID: 14595425.
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    93. Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel A. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003 Sep 19; 278(38):36754-62. PMID: 12842890.
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