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Eyal Raz

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0663
La Jolla CA 92093
Phone858-534-5444
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    Collapse Biography 
    Collapse Education and Training
    Hebrew University at the Hadassah Medical School , Jerusalem, IsraelMD1980

    Collapse Overview 
    Collapse Overview
    Research Interests
    - Fundamentals of innate immunity
    - TLR and the non-TLR activation pathways

    The research in my lab is focusing on the fundamentals of innate immunity. We study the Toll-like receptor (TLR) and the non-TLR activation pathways by which the host recognizes and responds to any microbial agent. We explore the consequences of this activation on antigen presentation by dendritic cells and its impact on priming of naïve CD4 and CD8 T cells as well as the generation of memory T cell responses.

    Using a similar strategy, we investigate the role of transient receptor potential (TRP) family members in inflammation. This approach to basic science helps us to develop vaccines against various infectious agents (e.g., HIV), tumors and allergic diseases (i.e., asthma). Some of the therapeutic approaches developed in our lab are already used in humans.

    Similarly, we explore the role of innate immunity in the inhibition of certain inflammatory conditions. In particular, we study the principles of host-commensal interaction in the G-I tract and explore how this interaction affects various inflammatory intestinal conditions and their human analogs such as inflammatory bowel disease and colitis-associated cancer.


    Collapse Research 
    Collapse Research Activities and Funding
    Control of mucosal immunity by Gas- vs Gai-linked GPCR signaling in dendritic cells
    NIH/NIAID U01AI125860Jun 6, 2016 - May 31, 2021
    Role: Principal Investigator
    The inductive role of Gs/Gi signaling in dendritic cell polarization and function
    NIH/NIAID R56AI110505Mar 10, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Th17 subsets: Differential roles in immune defense mechanisms at the G-I mucosa
    NIH/NIAID U01AI095623Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    The Impact of TLR on Intestinal Tumorigenesis
    NIH/NCI R21CA133702Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Mucosal adjuvants regulate inflammation and immunity
    NIH/NIAID R21AI083328Jun 5, 2009 - May 31, 2011
    Role: Principal Investigator
    The diverse contribution of TLR pathways to intestinal homeostasis
    NIH/NIAID R01AI068685Jul 1, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Mechanisms of CpG-Induced Inhibition of Allergic Asthma
    NIH/NIAID R01AI057709Sep 15, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Mechanisms of Tolerance Induction by Immunostimulatory *
    NIH/NHLBI R21HL079449Jul 12, 2004 - Jun 30, 2007
    Role: Principal Investigator
    TLR Ligand-Based Vaccines for SIV/HIV
    NIH/NIAID R01AI058743Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    ISS AS AN ADJUVANT FOR SIV/HIV-BASED VACCINE
    NIH/NIAID R21AI047078Apr 1, 2000 - Mar 31, 2003
    Role: Principal Investigator
    Critical Analysis of the Hygiene Hypothesis
    NIH/NIAID P01AI040682Sep 30, 1997 - Mar 31, 2008
    Role: Principal Investigator
    IMMUNE REGULATION BY INTRADERMAL GENE DELIVERY
    NIH/NIAID R01AI037305Sep 30, 1994 - Aug 31, 1997
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Viriyakosol S, Walls L, Okamoto S, Raz E, Williams DL, Fierer J. Myeloid differentiation factor 88 (MyD88) and IL-1R1 signaling contribute to resistance to Coccidioides immitis. Infect Immun. 2018 Apr 02. PMID: 29610256.
      View in: PubMed
    2. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. PMID: 28130546.
      View in: PubMed
    3. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 09; 66(9):1584-1596. PMID: 27325418.
      View in: PubMed
    4. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 May 17; 7:11551. PMID: 27187615; PMCID: PMC4873670.
    5. Samivel R, Kim DW, Son HR, Rhee YH, Kim EH, Kim JH, Bae JS, Chung YJ, Chung PS, Raz E, Mo JH. The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis. Oncotarget. 2016 Jan 05; 7(1):148-60. PMID: 26700618; PMCID: PMC4807989.
    6. Bertin S, Raz E. Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol. 2016 05; 38(3):309-19. PMID: 26468011.
      View in: PubMed
    7. Dann SM, Manthey CF, Le C, Miyamoto Y, Gima L, Abrahim A, Cao AT, Hanson EM, Kolls JK, Raz E, Cong Y, Eckmann L. IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia. Exp Parasitol. 2015 Sep; 156:68-78. PMID: 26071205; PMCID: PMC4547885.
    8. Bertin S, Raz E. [A novel role for the TRPV1 ion channel in CD4 T cell activation]. Med Sci (Paris). 2015 Feb; 31(2):135-6. PMID: 25744258.
      View in: PubMed
    9. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
    10. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. PMID: 25605931; PMCID: PMC4321256.
    11. de Jong PR, Bertin S, Raz E. TRPV1: Turning up the heat on intestinal tumorigenesis. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e975619. PMID: 27308393; PMCID: PMC4905246.
    12. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. PMID: 25282159; PMCID: PMC4843825.
    13. de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3793-806. PMID: 25083990; PMCID: PMC4151223.
    14. González-Navajas JM, Corr MP, Raz E. The immediate protective response to microbial challenge. Eur J Immunol. 2014 Sep; 44(9):2536-49. PMID: 24965684.
      View in: PubMed
    15. de Jong PR, Mo JH, Harris AR, Lee J, Raz E. STAT3: An Anti-Invasive Factor in Colorectal Cancer? Cancers (Basel). 2014 Jul 03; 6(3):1394-407. PMID: 24995503; PMCID: PMC4190547.
    16. Bertin S, de Jong PR, Jefferies WA, Raz E. Novel immune function for the TRPV1 channel in T lymphocytes. Channels (Austin). 2014; 8(6):479-80. PMID: 25530461; PMCID: PMC4594317.
    17. Zonneveld-Huijssoon E, van Wijk F, Roord S, Delemarre E, Meerding J, de Jager W, Klein M, Raz E, Albani S, Kuis W, Boes M, Prakken BJ. TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis. Ann Rheum Dis. 2012 Oct; 71(10):1706-15. PMID: 22562976.
      View in: PubMed
    18. Lee J, Kim JC, Lee SE, Quinley C, Kim H, Herdman S, Corr M, Raz E. Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J Biol Chem. 2012 May 25; 287(22):18182-9. PMID: 22496368; PMCID: PMC3365759.
    19. Lee SE, Li X, Kim JC, Lee J, González-Navajas JM, Hong SH, Park IK, Rhee JH, Raz E. Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Gastroenterology. 2012 Jul; 143(1):145-54. PMID: 22475534; PMCID: PMC3729390.
    20. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. Divergent requirement for Gas and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012 Mar; 122(3):963-73. PMID: 22326954; PMCID: PMC3287220.
    21. González-Navajas JM, Lee J, David M, Raz E. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Jan 06; 12(2):125-35. PMID: 22222875; PMCID: PMC3727154.
    22. Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R, Raz E. Autophagy suppresses interleukin-1ß (IL-1ß) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem. 2012 Feb 03; 287(6):4033-40. PMID: 22167182; PMCID: PMC3281713.
    23. Mo JH, Chung YJ, Hayashi T, Lee J, Raz E. The Role of Plasmacytoid and Myeloid Dendritic Cells in Induction of Asthma in a Mouse Model and the Effect of a TLR9 Agonist on Dendritic Cells. Allergy Asthma Immunol Res. 2011 Jul; 3(3):199-204. PMID: 21738886; PMCID: PMC3121062.
    24. González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20; 207(13):2799-807. PMID: 21115691; PMCID: PMC3005235.
    25. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. PMID: 20479237; PMCID: PMC2890829.
    26. Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010 Jun; 16(6):665-70. PMID: 20473309; PMCID: PMC2882530.
    27. Biderman P, Weinbroum AA, Rafaeli Y, Raz E, Porat E, Wiesel O, Szold O. Retrosternal percutaneous tracheostomy: an approach for predictably impossible classic tracheostomy. Crit Care Res Pract. 2010; 2010:397270. PMID: 20981321; PMCID: PMC2958601.
    28. González-Navajas JM, Fine S, Law J, Datta SK, Nguyen KP, Yu M, Corr M, Katakura K, Eckman L, Lee J, Raz E. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest. 2010 Feb; 120(2):570-81. PMID: 20051628; PMCID: PMC2810084.
    29. Raz E. Mucosal immunity: aliment and ailments. Mucosal Immunol. 2010 Jan; 3(1):4-7. PMID: 19890270.
      View in: PubMed
    30. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009 Jul 15; 183(2):1346-59. PMID: 19564341; PMCID: PMC2713016.
    31. Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565. PMID: 19203587.
      View in: PubMed
    32. Lee J, Abe K, Katakura K, Gonzalez-Navajas J, Raz E. The protective effects of type-1 interferon in models of intestinal inflammation. Adv Exp Med Biol. 2009; 633:1-6. PMID: 19209676.
      View in: PubMed
    33. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2008 May; 28(5):724. PMID: 18504811.
      View in: PubMed
    34. Lee J, Gonzales-Navajas JM, Raz E. The "polarizing-tolerizing" mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol. 2008 Feb; 30(1):3-9. PMID: 18026955.
      View in: PubMed
    35. Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18619-24. PMID: 18003900; PMCID: PMC2141826.
    36. Abe K, Nguyen KP, Fine SD, Mo JH, Shen C, Shenouda S, Corr M, Jung S, Lee J, Eckmann L, Raz E. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17022-7. PMID: 17942668; PMCID: PMC2040469.
    37. Raz E. Organ-specific regulation of innate immunity. Nat Immunol. 2007 Jan; 8(1):3-4. PMID: 17179960.
      View in: PubMed
    38. Lee J, Mo JH, Shen C, Rucker AN, Raz E. Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis. Curr Opin Gastroenterol. 2007 Jan; 23(1):27-31. PMID: 17133081.
      View in: PubMed
    39. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, Liu YT, Lee HK, Shen C, Cojocaru G, Shenouda S, Kagnoff M, Eckmann L, Ben-Neriah Y, Raz E. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006 Dec; 8(12):1327-36. PMID: 17128265.
      View in: PubMed
    40. Hayashi T, Raz E. TLR9-based immunotherapy for allergic disease. Am J Med. 2006 Oct; 119(10):897.e1-6. PMID: 17000223.
      View in: PubMed
    41. Lee J, Rachmilewitz D, Raz E. Homeostatic effects of TLR9 signaling in experimental colitis. Ann N Y Acad Sci. 2006 Aug; 1072:351-5. PMID: 17057215.
      View in: PubMed
    42. Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul; 25(1):143-52. PMID: 16860763.
      View in: PubMed
    43. Rachmilewitz D, Karmeli F, Shteingart S, Lee J, Takabayashi K, Raz E. Immunostimulatory oligonucleotides inhibit colonic proinflammatory cytokine production in ulcerative colitis. Inflamm Bowel Dis. 2006 May; 12(5):339-45. PMID: 16670522.
      View in: PubMed
    44. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2006 Apr; 24(4):475-87. PMID: 16618605.
      View in: PubMed
    45. Mo JH, Park SW, Rhee CS, Takabayashi K, Lee SS, Quan SH, Kim IS, Min IY, Raz E, Lee CH. Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis. Am J Rhinol. 2006 Mar-Apr; 20(2):212-8. PMID: 16686392.
      View in: PubMed
    46. Cho JY, Miller M, McElwain K, McElwain S, Shim JY, Raz E, Broide DH. Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA. J Allergy Clin Immunol. 2006 Mar; 117(3):618-25. PMID: 16522462.
      View in: PubMed
    47. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. PMID: 16446426; PMCID: PMC1413670.
    48. Lee SY, Cho JY, Miller M, McElwain K, McElwain S, Sriramarao P, Raz E, Broide DH. Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice. J Allergy Clin Immunol. 2006 Mar; 117(3):597-603. PMID: 16522459.
      View in: PubMed
    49. Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7. PMID: 16306937.
      View in: PubMed
    50. Kirkland TN, Raz E, Datta SK. Molecular and cellular mechanisms of protective immunity to coccidioidomycosis. Vaccine. 2006 Jan 23; 24(4):495-500. PMID: 16181709.
      View in: PubMed
    51. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 01; 45(2):303-10. PMID: 16002269.
      View in: PubMed
    52. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 01; 174(9):5864-73. PMID: 15843591.
      View in: PubMed
    53. Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005 Mar; 115(3):695-702. PMID: 15765149; PMCID: PMC1051992.
    54. Youn CJ, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol. 2004 Dec 15; 173(12):7556-64. PMID: 15585883.
      View in: PubMed
    55. Horner AA, Redecke V, Raz E. Toll-like receptor ligands: hygiene, atopy and therapeutic implications. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):555-61. PMID: 15640699.
      View in: PubMed
    56. Datta SK, Raz E. Induction of antigen cross-presentation by Toll-like receptors. Springer Semin Immunopathol. 2005 Jan; 26(3):247-55. PMID: 15609002.
      View in: PubMed
    57. Rhee CS, Libet L, Chisholm D, Takabayashi K, Baird S, Bigby TD, Lee CH, Horner AA, Raz E. Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis. Immunology. 2004 Sep; 113(1):106-13. PMID: 15312141; PMCID: PMC1782540.
    58. Fanucchi MV, Schelegle ES, Baker GL, Evans MJ, McDonald RJ, Gershwin LJ, Raz E, Hyde DM, Plopper CG, Miller LA. Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. Am J Respir Crit Care Med. 2004 Dec 01; 170(11):1153-7. PMID: 15306532; PMCID: PMC3927836.
    59. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. PMID: 15254594; PMCID: PMC449749.
    60. Wu CC, Lee J, Raz E, Corr M, Carson DA. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem. 2004 Aug 06; 279(32):33071-8. PMID: 15184382.
      View in: PubMed
    61. Datta SK, Cho HJ, Takabayashi K, Horner AA, Raz E. Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications. Immunol Rev. 2004 Jun; 199:217-26. PMID: 15233737.
      View in: PubMed
    62. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004 Mar 01; 172(5):2739-43. PMID: 14978071.
      View in: PubMed
    63. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 2004 Feb; 126(2):520-8. PMID: 14762789.
      View in: PubMed
    64. Horner AA, Raz E. Do microbes influence the pathogenesis of allergic diseases? Building the case for Toll-like receptor ligands. Curr Opin Immunol. 2003 Dec; 15(6):614-9. PMID: 14630193.
      View in: PubMed
    65. Datta SK, Takabayashi K, Raz E. The therapeutic potential of antigen-oligonucleotide conjugates. Ann N Y Acad Sci. 2003 Dec; 1002:105-11. PMID: 14751828.
      View in: PubMed
    66. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 2004 May; 30(5):651-61. PMID: 14617508.
      View in: PubMed
    67. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide DH. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol. 2003 Nov 01; 171(9):4860-7. PMID: 14568966.
      View in: PubMed
    68. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide DH. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol. 2003 Jun; 28(6):655-63. PMID: 12760963.
      View in: PubMed
    69. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. PMID: 12738885; PMCID: PMC164501.
    70. Datta SK, Redecke V, Prilliman KR, Takabayashi K, Corr M, Tallant T, DiDonato J, Dziarski R, Akira S, Schoenberger SP, Raz E. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol. 2003 Apr 15; 170(8):4102-10. PMID: 12682240.
      View in: PubMed
    71. Spiegelberg HL, Horner AA, Takabayashi K, Raz E. Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr Opin Allergy Clin Immunol. 2002 Dec; 2(6):547-51. PMID: 14752340.
      View in: PubMed
    72. Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J Allergy Clin Immunol. 2002 Nov; 110(5):706-12. PMID: 12417878.
      View in: PubMed
    73. Joseph A, Louria-Hayon I, Plis-Finarov A, Zeira E, Zakay-Rones Z, Raz E, Hayashi T, Takabayashi K, Barenholz Y, Kedar E. Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines. Vaccine. 2002 Sep 10; 20(27-28):3342-54. PMID: 12213404.
      View in: PubMed
    74. Horner AA, Takabayashi K, Beck L, Sharma B, Zubeldia J, Baird S, Tuck S, Libet L, Spiegelberg HL, Liu FT, Raz E. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol. 2002 Sep; 110(3):413-20. PMID: 12209088.
      View in: PubMed
    75. Spiegelberg HL, Takabayashi K, Beck L, Raz E. DNA-based vaccines for allergic disease. Expert Rev Vaccines. 2002 Aug; 1(2):169-77. PMID: 12901556.
      View in: PubMed
    76. Miller M, Cho JY, Baek KJ, Castaneda D, Nayar J, Rodriguez M, Roman M, Raz E, Broide DH. Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness. Vaccine. 2002 Jul 26; 20(23-24):3023-33. PMID: 12126916.
      View in: PubMed
    77. Cho HJ, Hayashi T, Datta SK, Takabayashi K, Van Uden JH, Horner A, Corr M, Raz E. IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol. 2002 May 15; 168(10):4907-13. PMID: 11994440.
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