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    Eyal Raz

    TitleRecall Faculty
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0663
    CA La Jolla 92093
    Phone858-534-5444
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      Collapse Research 
      Collapse Research Activities and Funding
      Control of mucosal immunity by Gas- vs Gai-linked GPCR signaling in dendritic cells
      NIH/NIAID U01AI125860Jun 6, 2016 - May 31, 2021
      Role: Principal Investigator
      The inductive role of Gs/Gi signaling in dendritic cell polarization and function
      NIH/NIAID R56AI110505Mar 10, 2015 - Feb 29, 2016
      Role: Principal Investigator
      Th17 subsets: Differential roles in immune defense mechanisms at the G-I mucosa
      NIH/NIAID U01AI095623Jul 1, 2011 - Jun 30, 2016
      Role: Principal Investigator
      The Impact of TLR on Intestinal Tumorigenesis
      NIH/NCI R21CA133702Jul 1, 2009 - Jun 30, 2011
      Role: Principal Investigator
      Mucosal adjuvants regulate inflammation and immunity
      NIH/NIAID R21AI083328Jun 5, 2009 - May 31, 2011
      Role: Principal Investigator
      The diverse contribution of TLR pathways to intestinal homeostasis
      NIH/NIAID R01AI068685Jul 1, 2007 - Nov 30, 2013
      Role: Principal Investigator
      Mechanisms of CpG-Induced Inhibition of Allergic Asthma
      NIH/NIAID R01AI057709Sep 15, 2004 - Dec 31, 2008
      Role: Principal Investigator
      Mechanisms of Tolerance Induction by Immunostimulatory *
      NIH/NHLBI R21HL079449Jul 12, 2004 - Jun 30, 2007
      Role: Principal Investigator
      TLR Ligand-Based Vaccines for SIV/HIV
      NIH/NIAID R01AI058743Jun 1, 2004 - May 31, 2010
      Role: Principal Investigator
      ISS AS AN ADJUVANT FOR SIV/HIV-BASED VACCINE
      NIH/NIAID R21AI047078Apr 1, 2000 - Mar 31, 2003
      Role: Principal Investigator
      Critical Analysis of the Hygiene Hypothesis
      NIH/NIAID P01AI040682Sep 30, 1997 - Mar 31, 2008
      Role: Principal Investigator
      IMMUNE REGULATION BY INTRADERMAL GENE DELIVERY
      NIH/NIAID R01AI037305Sep 30, 1994 - Aug 31, 1997
      Role: Principal Investigator
      INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
      NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1643-1648. PMID: 28130546.
        View in: PubMed
      2. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 Sep; 66(9):1584-1596. PMID: 27325418.
        View in: PubMed
      3. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 May 17; 7:11551. PMID: 27187615; PMCID: PMC4873670.
      4. Kister I, Johnson E, Raz E, Babb J, Loh J, Shepherd TM. Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. Mult Scler Relat Disord. 2016 Sep; 9:62-7. PMID: 27645347.
        View in: PubMed
      5. Samivel R, Kim DW, Son HR, Rhee YH, Kim EH, Kim JH, Bae JS, Chung YJ, Chung PS, Raz E, Mo JH. The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis. Oncotarget. 2016 Jan 05; 7(1):148-60. PMID: 26700618; PMCID: PMC4807989.
      6. Bertin S, Raz E. Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol. 2016 May; 38(3):309-19. PMID: 26468011; PMCID: PMC4833713 [Available on 05/01/17].
      7. Dann SM, Manthey CF, Le C, Miyamoto Y, Gima L, Abrahim A, Cao AT, Hanson EM, Kolls JK, Raz E, Cong Y, Eckmann L. IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia. Exp Parasitol. 2015 Sep; 156:68-78. PMID: 26071205; PMCID: PMC4547885.
      8. Bertin S, Raz E. [A novel role for the TRPV1 ion channel in CD4 T cell activation]. Med Sci (Paris). 2015 Feb; 31(2):135-6. PMID: 25744258.
        View in: PubMed
      9. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
      10. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. PMID: 25605931; PMCID: PMC4321256.
      11. de Jong PR, Bertin S, Raz E. TRPV1: Turning up the heat on intestinal tumorigenesis. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e975619. PMID: 27308393; PMCID: PMC4905246.
      12. de Jong PR, Takahashi N, Peiris M, Bertin S, Lee J, Gareau MG, Paniagua A, Harris AR, Herdman DS, Corr M, Blackshaw LA, Raz E. TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. Mucosal Immunol. 2015 May; 8(3):491-504. PMID: 25269705; PMCID: PMC4382463.
      13. Bertin S, Lozano-Ruiz B, Bachiller V, García-Martínez I, Herdman S, Zapater P, Francés R, Such J, Lee J, Raz E, González-Navajas JM. Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol. 2015 May; 8(3):505-15. PMID: 25227984; PMCID: PMC4363301.
      14. de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3793-806. PMID: 25083990; PMCID: PMC4151223.
      15. González-Navajas JM, Corr MP, Raz E. The immediate protective response to microbial challenge. Eur J Immunol. 2014 Sep; 44(9):2536-49. PMID: 24965684.
        View in: PubMed
      16. de Jong PR, Mo JH, Harris AR, Lee J, Raz E. STAT3: An Anti-Invasive Factor in Colorectal Cancer? Cancers (Basel). 2014 Jul 03; 6(3):1394-407. PMID: 24995503; PMCID: PMC4190547.
      17. Bertin S, de Jong PR, Jefferies WA, Raz E. Novel immune function for the TRPV1 channel in T lymphocytes. Channels (Austin). 2014; 8(6):479-80. PMID: 25530461; PMCID: PMC4594317.
      18. Zonneveld-Huijssoon E, van Wijk F, Roord S, Delemarre E, Meerding J, de Jager W, Klein M, Raz E, Albani S, Kuis W, Boes M, Prakken BJ. TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis. Ann Rheum Dis. 2012 Oct; 71(10):1706-15. PMID: 22562976.
        View in: PubMed
      19. Lee J, Kim JC, Lee SE, Quinley C, Kim H, Herdman S, Corr M, Raz E. Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J Biol Chem. 2012 May 25; 287(22):18182-9. PMID: 22496368; PMCID: PMC3365759.
      20. Lee SE, Li X, Kim JC, Lee J, González-Navajas JM, Hong SH, Park IK, Rhee JH, Raz E. Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Gastroenterology. 2012 Jul; 143(1):145-54. PMID: 22475534; PMCID: PMC3729390.
      21. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. Divergent requirement for Gas and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012 Mar; 122(3):963-73. PMID: 22326954; PMCID: PMC3287220.
      22. González-Navajas JM, Lee J, David M, Raz E. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Jan 06; 12(2):125-35. PMID: 22222875; PMCID: PMC3727154.
      23. Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R, Raz E. Autophagy suppresses interleukin-1ß (IL-1ß) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem. 2012 Feb 03; 287(6):4033-40. PMID: 22167182; PMCID: PMC3281713.
      24. Mo JH, Chung YJ, Hayashi T, Lee J, Raz E. The Role of Plasmacytoid and Myeloid Dendritic Cells in Induction of Asthma in a Mouse Model and the Effect of a TLR9 Agonist on Dendritic Cells. Allergy Asthma Immunol Res. 2011 Jul; 3(3):199-204. PMID: 21738886; PMCID: PMC3121062.
      25. González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20; 207(13):2799-807. PMID: 21115691; PMCID: PMC3005235.
      26. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. PMID: 20479237; PMCID: PMC2890829.
      27. Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010 Jun; 16(6):665-70. PMID: 20473309; PMCID: PMC2882530.
      28. Biderman P, Weinbroum AA, Rafaeli Y, Raz E, Porat E, Wiesel O, Szold O. Retrosternal percutaneous tracheostomy: an approach for predictably impossible classic tracheostomy. Crit Care Res Pract. 2010; 2010:397270. PMID: 20981321; PMCID: PMC2958601.
      29. González-Navajas JM, Fine S, Law J, Datta SK, Nguyen KP, Yu M, Corr M, Katakura K, Eckman L, Lee J, Raz E. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest. 2010 Feb; 120(2):570-81. PMID: 20051628; PMCID: PMC2810084.
      30. Raz E. Mucosal immunity: aliment and ailments. Mucosal Immunol. 2010 Jan; 3(1):4-7. PMID: 19890270.
        View in: PubMed
      31. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009 Jul 15; 183(2):1346-59. PMID: 19564341; PMCID: PMC2713016.
      32. Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565. PMID: 19203587.
        View in: PubMed
      33. Lee J, Abe K, Katakura K, Gonzalez-Navajas J, Raz E. The protective effects of type-1 interferon in models of intestinal inflammation. Adv Exp Med Biol. 2009; 633:1-6. PMID: 19209676.
        View in: PubMed
      34. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2008 May; 28(5):724. PMID: 18504811.
        View in: PubMed
      35. Lee J, Gonzales-Navajas JM, Raz E. The "polarizing-tolerizing" mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol. 2008 Feb; 30(1):3-9. PMID: 18026955.
        View in: PubMed
      36. Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18619-24. PMID: 18003900; PMCID: PMC2141826.
      37. Abe K, Nguyen KP, Fine SD, Mo JH, Shen C, Shenouda S, Corr M, Jung S, Lee J, Eckmann L, Raz E. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17022-7. PMID: 17942668; PMCID: PMC2040469.
      38. Lee J, Mo JH, Shen C, Rucker AN, Raz E. Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis. Curr Opin Gastroenterol. 2007 Jan; 23(1):27-31. PMID: 17133081.
        View in: PubMed
      39. Raz E. Organ-specific regulation of innate immunity. Nat Immunol. 2007 Jan; 8(1):3-4. PMID: 17179960.
        View in: PubMed
      40. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, Liu YT, Lee HK, Shen C, Cojocaru G, Shenouda S, Kagnoff M, Eckmann L, Ben-Neriah Y, Raz E. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006 Dec; 8(12):1327-36. PMID: 17128265.
        View in: PubMed
      41. Hayashi T, Raz E. TLR9-based immunotherapy for allergic disease. Am J Med. 2006 Oct; 119(10):897.e1-6. PMID: 17000223.
        View in: PubMed
      42. Lee J, Rachmilewitz D, Raz E. Homeostatic effects of TLR9 signaling in experimental colitis. Ann N Y Acad Sci. 2006 Aug; 1072:351-5. PMID: 17057215.
        View in: PubMed
      43. Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul; 25(1):143-52. PMID: 16860763.
        View in: PubMed
      44. Rachmilewitz D, Karmeli F, Shteingart S, Lee J, Takabayashi K, Raz E. Immunostimulatory oligonucleotides inhibit colonic proinflammatory cytokine production in ulcerative colitis. Inflamm Bowel Dis. 2006 May; 12(5):339-45. PMID: 16670522.
        View in: PubMed
      45. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2006 Apr; 24(4):475-87. PMID: 16618605.
        View in: PubMed
      46. Cho JY, Miller M, McElwain K, McElwain S, Shim JY, Raz E, Broide DH. Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA. J Allergy Clin Immunol. 2006 Mar; 117(3):618-25. PMID: 16522462.
        View in: PubMed
      47. Mo JH, Park SW, Rhee CS, Takabayashi K, Lee SS, Quan SH, Kim IS, Min IY, Raz E, Lee CH. Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis. Am J Rhinol. 2006 Mar-Apr; 20(2):212-8. PMID: 16686392.
        View in: PubMed
      48. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. PMID: 16446426; PMCID: PMC1413670.
      49. Lee SY, Cho JY, Miller M, McElwain K, McElwain S, Sriramarao P, Raz E, Broide DH. Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice. J Allergy Clin Immunol. 2006 Mar; 117(3):597-603. PMID: 16522459.
        View in: PubMed
      50. Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7. PMID: 16306937.
        View in: PubMed
      51. Kirkland TN, Raz E, Datta SK. Molecular and cellular mechanisms of protective immunity to coccidioidomycosis. Vaccine. 2006 Jan 23; 24(4):495-500. PMID: 16181709.
        View in: PubMed
      52. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 01; 45(2):303-10. PMID: 16002269.
        View in: PubMed
      53. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 01; 174(9):5864-73. PMID: 15843591.
        View in: PubMed
      54. Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005 Mar; 115(3):695-702. PMID: 15765149; PMCID: PMC1051992.
      55. Youn CJ, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol. 2004 Dec 15; 173(12):7556-64. PMID: 15585883.
        View in: PubMed
      56. Horner AA, Redecke V, Raz E. Toll-like receptor ligands: hygiene, atopy and therapeutic implications. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):555-61. PMID: 15640699.
        View in: PubMed
      57. Datta SK, Raz E. Induction of antigen cross-presentation by Toll-like receptors. Springer Semin Immunopathol. 2005 Jan; 26(3):247-55. PMID: 15609002.
        View in: PubMed
      58. Rhee CS, Libet L, Chisholm D, Takabayashi K, Baird S, Bigby TD, Lee CH, Horner AA, Raz E. Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis. Immunology. 2004 Sep; 113(1):106-13. PMID: 15312141; PMCID: PMC1782540.
      59. Fanucchi MV, Schelegle ES, Baker GL, Evans MJ, McDonald RJ, Gershwin LJ, Raz E, Hyde DM, Plopper CG, Miller LA. Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. Am J Respir Crit Care Med. 2004 Dec 01; 170(11):1153-7. PMID: 15306532; PMCID: PMC3927836.
      60. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. PMID: 15254594; PMCID: PMC449749.
      61. Wu CC, Lee J, Raz E, Corr M, Carson DA. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem. 2004 Aug 06; 279(32):33071-8. PMID: 15184382.
        View in: PubMed
      62. Datta SK, Cho HJ, Takabayashi K, Horner AA, Raz E. Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications. Immunol Rev. 2004 Jun; 199:217-26. PMID: 15233737.
        View in: PubMed
      63. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004 Mar 01; 172(5):2739-43. PMID: 14978071.
        View in: PubMed
      64. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 2004 Feb; 126(2):520-8. PMID: 14762789.
        View in: PubMed
      65. Horner AA, Raz E. Do microbes influence the pathogenesis of allergic diseases? Building the case for Toll-like receptor ligands. Curr Opin Immunol. 2003 Dec; 15(6):614-9. PMID: 14630193.
        View in: PubMed
      66. Datta SK, Takabayashi K, Raz E. The therapeutic potential of antigen-oligonucleotide conjugates. Ann N Y Acad Sci. 2003 Dec; 1002:105-11. PMID: 14751828.
        View in: PubMed
      67. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 2004 May; 30(5):651-61. PMID: 14617508.
        View in: PubMed
      68. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide DH. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol. 2003 Nov 01; 171(9):4860-7. PMID: 14568966.
        View in: PubMed
      69. Matricardi PM, Bjorksten B, Bonini S, Bousquet J, Djukanovic R, Dreborg S, Gereda J, Malling HJ, Popov T, Raz E, Renz H, Wold A. Microbial products in allergy prevention and therapy. Allergy. 2003 Jun; 58(6):461-71. PMID: 12757444.
        View in: PubMed
      70. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide DH. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol. 2003 Jun; 28(6):655-63. PMID: 12760963.
        View in: PubMed
      71. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. PMID: 12738885; PMCID: PMC164501.
      72. Datta SK, Redecke V, Prilliman KR, Takabayashi K, Corr M, Tallant T, DiDonato J, Dziarski R, Akira S, Schoenberger SP, Raz E. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol. 2003 Apr 15; 170(8):4102-10. PMID: 12682240.
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      73. Spiegelberg HL, Horner AA, Takabayashi K, Raz E. Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr Opin Allergy Clin Immunol. 2002 Dec; 2(6):547-51. PMID: 14752340.
        View in: PubMed
      74. Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J Allergy Clin Immunol. 2002 Nov; 110(5):706-12. PMID: 12417878.
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      75. Joseph A, Louria-Hayon I, Plis-Finarov A, Zeira E, Zakay-Rones Z, Raz E, Hayashi T, Takabayashi K, Barenholz Y, Kedar E. Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines. Vaccine. 2002 Sep 10; 20(27-28):3342-54. PMID: 12213404.
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      76. Horner AA, Takabayashi K, Beck L, Sharma B, Zubeldia J, Baird S, Tuck S, Libet L, Spiegelberg HL, Liu FT, Raz E. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol. 2002 Sep; 110(3):413-20. PMID: 12209088.
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      77. Spiegelberg HL, Takabayashi K, Beck L, Raz E. DNA-based vaccines for allergic disease. Expert Rev Vaccines. 2002 Aug; 1(2):169-77. PMID: 12901556.
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      78. Miller M, Cho JY, Baek KJ, Castaneda D, Nayar J, Rodriguez M, Roman M, Raz E, Broide DH. Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness. Vaccine. 2002 Jul 26; 20(23-24):3023-33. PMID: 12126916.
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      79. Cho HJ, Hayashi T, Datta SK, Takabayashi K, Van Uden JH, Horner A, Corr M, Raz E. IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol. 2002 May 15; 168(10):4907-13. PMID: 11994440.
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      80. Rachmilewitz D, Karmeli F, Takabayashi K, Hayashi T, Leider-Trejo L, Lee J, Leoni LM, Raz E. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology. 2002 May; 122(5):1428-41. PMID: 11984528.
        View in: PubMed
      81. Spiegelberg HL, Raz E. DNA-based approaches to the treatment of allergies. Curr Opin Mol Ther. 2002 Feb; 4(1):64-71. PMID: 11883696.
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      82. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. PMID: 11751945.
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      83. Horner AA, Takabaysahi K, Zubeldia JM, Raz E. Immunostimulatory DNA-based therapeutics for experimental and clinical allergy. Allergy. 2002; 57 Suppl 72:24-9. PMID: 12144550.
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      84. Van Uden JH, Tran CH, Carson DA, Raz E. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol. 2001 Nov; 31(11):3281-90. PMID: 11745345.
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      85. Broide DH, Stachnick G, Castaneda D, Nayar J, Miller M, Cho J, Rodriquez M, Roman M, Raz E. Immunostimulatory DNA mediates inhibition of eosinophilic inflammation and airway hyperreactivity independent of natural killer cells in vivo. J Allergy Clin Immunol. 2001 Nov; 108(5):759-63. PMID: 11692101.
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      86. Cho JY, Miller M, Baek KJ, Castaneda D, Nayar J, Roman M, Raz E, Broide DH. Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion. J Allergy Clin Immunol. 2001 Nov; 108(5):697-702. PMID: 11692091.
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      87. Hayashi T, Rao SP, Takabayashi K, Van Uden JH, Kornbluth RS, Baird SM, Taylor MW, Carson DA, Catanzaro A, Raz E. Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase. Infect Immun. 2001 Oct; 69(10):6156-64. PMID: 11553555; PMCID: PMC98746.
      88. Horner AA, Widhopf GF, Burger JA, Takabayashi K, Cinman N, Ronaghy A, Spiegelberg HL, Raz E. Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells. J Allergy Clin Immunol. 2001 Sep; 108(3):417-23. PMID: 11544462.
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      89. Uchijima M, Raz E, Carson DA, Nagata T, Koide Y. Identification of immunostimulatory DNA-induced genes by suppression subtractive hybridization. Biochem Biophys Res Commun. 2001 Aug 31; 286(4):688-91. PMID: 11520051.
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      90. Horner AA, Datta SK, Takabayashi K, Belyakov IM, Hayashi T, Cinman N, Nguyen MD, Van Uden JH, Berzofsky JA, Richman DD, Raz E. Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J Immunol. 2001 Aug 01; 167(3):1584-91. PMID: 11466380.
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      91. Broide DH, Stachnick G, Castaneda D, Nayar J, Miller M, Cho JY, Roman M, Zubeldia J, Hayashi T, Raz E, Hyashi T. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma. J Clin Immunol. 2001 May; 21(3):175-82. PMID: 11403224.
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      92. Ayash-Rashkovsky M, Weisman Z, Zlotnikov S, Raz E, Bentwich Z, Borkow G. Induction of antigen-specific Th1-biased immune responses by plasmid DNA in schistosoma-infected mice with a preexistent dominant Th2 immune profile. Biochem Biophys Res Commun. 2001 Apr 20; 282(5):1169-76. PMID: 11302738.
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      93. Horner AA, Van Uden JH, Zubeldia JM, Broide D, Raz E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Rev. 2001 Feb; 179:102-18. PMID: 11292014.
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      94. Chu W, Gong X, Li Z, Takabayashi K, Ouyang H, Chen Y, Lois A, Chen DJ, Li GC, Karin M, Raz E. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2000 Dec 08; 103(6):909-18. PMID: 11136976.
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      95. Horner AA, Nguyen MD, Ronaghy A, Cinman N, Verbeek S, Raz E. DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice. J Allergy Clin Immunol. 2000 Aug; 106(2):349-56. PMID: 10932080.
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      96. Tighe H, Takabayashi K, Schwartz D, Van Nest G, Tuck S, Eiden JJ, Kagey-Sobotka A, Creticos PS, Lichtenstein LM, Spiegelberg HL, Raz E. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol. 2000 Jul; 106(1 Pt 1):124-34. PMID: 10887315.
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      97. Magone MT, Chan CC, Beck L, Whitcup SM, Raz E. Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis. Eur J Immunol. 2000 Jul; 30(7):1841-50. PMID: 10940873.
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      98. Tighe H, Takabayashi K, Schwartz D, Marsden R, Beck L, Corbeil J, Richman DD, Eiden JJ, Spiegelberg HL, Raz E. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity. Eur J Immunol. 2000 Jul; 30(7):1939-47. PMID: 10940883.
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      99. Cho HJ, Takabayashi K, Cheng PM, Nguyen MD, Corr M, Tuck S, Raz E. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nat Biotechnol. 2000 May; 18(5):509-14. PMID: 10802617.
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      100. Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide: A novel mucosal adjuvant. Clin Immunol. 2000 Apr; 95(1 Pt 2):S19-29. PMID: 10729234.
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      101. Horner AA, Cinman N, Ronaghy A, Raz E. Mucosal adjuvanticity of immunostimulatory DNA sequences. Springer Semin Immunopathol. 2000; 22(1-2):133-46. PMID: 10944808.
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      102. Van Uden J, Raz E. Introduction to immunostimulatory DNA sequences. Springer Semin Immunopathol. 2000; 22(1-2):1-9. PMID: 10944795.
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      103. Kobayashi H, Horner AA, Martin-Orozco E, Raz E. Pre-priming: a novel approach to DNA-based vaccination and immunomodulation. Springer Semin Immunopathol. 2000; 22(1-2):85-96. PMID: 10944803.
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      104. Broide D, Cho JY, Miller M, Nayar J, Stachnick G, Castaneda D, Roman M, Raz E. Modulation of asthmatic response by immunostimulatory DNA sequences. Springer Semin Immunopathol. 2000; 22(1-2):117-24. PMID: 10944806.
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      105. Horner AA, Raz E. Immunostimulatory-sequence DNA is an effective mucosal adjuvant. Curr Top Microbiol Immunol. 2000; 247:185-98. PMID: 10689788.
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      106. Van Uden JH, Raz E. Immunostimulatory DNA sequences : an overview. Methods Mol Med. 2000; 29:145-68. PMID: 21374317.
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      107. Roman M, Tighe H, Spiegelberg HL, Broide D, Raz E. Genetic immunization for allergy immunotherapy. Methods Mol Med. 2000; 29:451-72. PMID: 21374341.
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      108. Kobayashi H, Horner AA, Takabayashi K, Nguyen MD, Huang E, Cinman N, Raz E. Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity. Cell Immunol. 1999 Nov 25; 198(1):69-75. PMID: 10612653.
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      109. Van Uden J, Raz E. Immunostimulatory DNA and applications to allergic disease. J Allergy Clin Immunol. 1999 Nov; 104(5):902-10. PMID: 10550730.
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      110. Zhang Q, Yaniv K, Oberman F, Wolke U, Git A, Fromer M, Taylor WL, Meyer D, Standart N, Raz E, Yisraeli JK. Vg1 RBP intracellular distribution and evolutionarily conserved expression at multiple stages during development. Mech Dev. 1999 Oct; 88(1):101-6. PMID: 10525193.
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      111. Martin-Orozco E, Kobayashi H, Van Uden J, Nguyen MD, Kornbluth RS, Raz E. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int Immunol. 1999 Jul; 11(7):1111-8. PMID: 10383944.
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      112. Broide D, Raz E. DNA-Based immunization for asthma. Int Arch Allergy Immunol. 1999 Feb-Apr; 118(2-4):453-6. PMID: 10224473.
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      113. Spiegelberg HL, Broide D, Tighe H, Roman M, Raz E. Inhibition of allergic inflammation in the lung by plasmid DNA allergen immunization. Pediatr Pulmonol Suppl. 1999; 18:118-21. PMID: 10093118.
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      114. Spiegelberg HL, Raz E. DNA vaccines. Allergy. 1999; 54 Suppl 56:47-8. PMID: 10532307.
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      115. Raz E, Spiegelberg HL. Deviation of the allergic IgE to an IgG response by gene immunotherapy. Int Rev Immunol. 1999; 18(3):271-89. PMID: 10614729.
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      116. Spiegelberg HL, Raz E. DNA based immunotherapeutics for allergy. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 1999; (93):283-90; discussion 291-2. PMID: 11487889.
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      117. Broide D, Schwarze J, Tighe H, Gifford T, Nguyen MD, Malek S, Van Uden J, Martin-Orozco E, Gelfand EW, Raz E. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol. 1998 Dec 15; 161(12):7054-62. PMID: 9862743.
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      118. Horner AA, Ronaghy A, Cheng PM, Nguyen MD, Cho HJ, Broide D, Raz E. Immunostimulatory DNA is a potent mucosal adjuvant. Cell Immunol. 1998 Nov 25; 190(1):77-82. PMID: 9826449.
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      119. Goodman JS, Van Uden JH, Kobayashi H, Broide D, Raz E. DNA immunotherapeutics: new potential treatment modalities for allergic disease. Int Arch Allergy Immunol. 1998 Jul; 116(3):177-87. PMID: 9693265.
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      120. Tighe H, Corr M, Roman M, Raz E. Gene vaccination: plasmid DNA is more than just a blueprint. Immunol Today. 1998 Feb; 19(2):89-97. PMID: 9509764.
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      121. Spiegelberg HL, Tighe H, Roman M, Broide D, Raz E. Inhibition of IgE formation and allergic inflammation by allergen gene immunization and by CpG motif immunostimulatory oligodeoxynucleotides. Allergy. 1998; 53(45 Suppl):93-7. PMID: 9788716.
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      122. O'Keefe L, Dougan ST, Gabay L, Raz E, Shilo BZ, DiNardo S. Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. Development. 1997 Dec; 124(23):4837-45. PMID: 9428420.
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      123. Carson DA, Raz E. Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination. J Exp Med. 1997 Nov 17; 186(10):1621-2. PMID: 9411016; PMCID: PMC2199144.
      124. Goodman JS, Raz E. Circling back to gene vaccines. Gastroenterology. 1997 Nov; 113(5):1812-4. PMID: 9352896.
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      125. Spiegelberg HL, Orozco EM, Roman M, Raz E. DNA immunization: a novel approach to allergen-specific immunotherapy. Allergy. 1997 Oct; 52(10):964-70. PMID: 9360746.
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      126. Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med. 1997 Aug; 3(8):849-54. PMID: 9256274.
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      127. Lee DJ, Tighe H, Corr M, Roman M, Carson DA, Spiegelberg HL, Raz E. Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells. Int Arch Allergy Immunol. 1997 May-Jul; 113(1-3):227-30. PMID: 9130530.
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      128. Roman M, Spiegelberg HL, Broide D, Raz E. Gene immunization for allergic disorders. Springer Semin Immunopathol. 1997; 19(2):223-32. PMID: 9406348.
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      129. Raz E. Introduction: gene vaccination, current concepts and future directions. Springer Semin Immunopathol. 1997; 19(2):131-7. PMID: 9406341.
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      130. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, Silverman GJ, Lotz M, Carson DA, Raz E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 1996 Jul 19; 273(5273):352-4. PMID: 8662521.
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      131. Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, Swain SL, Spiegelberg HL, Carson DA. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):5141-5. PMID: 8643542; PMCID: PMC39421.
      132. Raz E, Dudler J, Lotz M, Baird SM, Berry CC, Eisenberg RA, Carson DA. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus. 1995 Aug; 4(4):286-92. PMID: 8528225.
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      133. Giladi E, Raz E, Karmeli F, Okon E, Rachmilewitz D. Transforming growth factor-beta gene therapy ameliorates experimental colitis in rats. Eur J Gastroenterol Hepatol. 1995 Apr; 7(4):341-7. PMID: 7600140.
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      134. Raz E, Carson DA, Parker SE, Parr TB, Abai AM, Aichinger G, Gromkowski SH, Singh M, Lew D, Yankauckas MA. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9519-23. PMID: 7937799; PMCID: PMC44844.
      135. Mevorach D, Raz E, Steiner I. Evidence for intrathecal synthesis of autoantibodies in systemic lupus erythematosus with neurological involvement. Lupus. 1994 Apr; 3(2):117-21. PMID: 7920611.
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      136. Watanabe A, Raz E, Kohsaka H, Tighe H, Baird SM, Kipps TJ, Carson DA. Induction of antibodies to a kappa V region by gene immunization. J Immunol. 1993 Sep 01; 151(5):2871-6. PMID: 8360497.
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      137. Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, Lotz M, Kipps TJ, Carson DA. Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4523-7. PMID: 8506293; PMCID: PMC46544.
      138. Mevorach D, Raz E, Shalev O, Steiner I, Ben-Chetrit E. Complete heart block and seizures in an adult with systemic lupus erythematosus. A possible pathophysiologic role for anti-SS-A/Ro and anti-SS-B/La autoantibodies. Arthritis Rheum. 1993 Feb; 36(2):259-62. PMID: 8431216.
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      139. Raz E, Ben-Bassat H, Davidi T, Shlomai Z, Eilat D. Cross-reactions of anti-DNA autoantibodies with cell surface proteins. Eur J Immunol. 1993 Feb; 23(2):383-90. PMID: 7679642.
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      140. Mevorach D, Leibowitz G, Brezis M, Raz E. Induction of remission in a patient with Takayasu's arteritis by low dose pulses of methotrexate. Ann Rheum Dis. 1992 Jul; 51(7):904-5. PMID: 1352962; PMCID: PMC1004779.
      141. Raz E, Bursztyn M, Rosenthal T, Rubinow A, Karem E. Severe recurrent lupus laryngitis. Am J Med. 1992 Jan; 92(1):109-10. PMID: 1731501.
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      142. Shilo BZ, Raz E. Developmental control by the Drosophila EGF receptor homolog DER. Trends Genet. 1991 Nov-Dec; 7(11-12):388-92. PMID: 1820687.
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      143. Raz E, Schejter ED, Shilo BZ. Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases. Genetics. 1991 Sep; 129(1):191-201. PMID: 1936959; PMCID: PMC1204566.
      144. Maaravi Y, Raz E. [Cardiac involvement in systemic lupus erythematosus]. Harefuah. 1991 Feb 15; 120(4):227-30. PMID: 2066031.
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      145. Maaravi Y, Raz E, Gilon D, Rubinow A. Cerebrovascular accident and myocardial infarction associated with anticardiolipin antibodies in a young woman with systemic lupus erythematosus. Ann Rheum Dis. 1989 Oct; 48(10):853-5. PMID: 2637695; PMCID: PMC1003894.
      146. Raz E, Brezis M, Rosenmann E, Eilat D. Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney. J Immunol. 1989 May 01; 142(9):3076-82. PMID: 2785132.
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      147. Raz E, Michaeli J, Rosenmann E, Rubinow A, Popovtzer MM. Antinuclear antibody-negative systemic lupus erythematosus (SLE) and severe renal involvement: close correlation between disease activity and appearance of circulating anticoagulant. Isr J Med Sci. 1988 Feb; 24(2):105-8. PMID: 3128493.
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