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Eyal Raz

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Hebrew University at the Hadassah Medical School , Jerusalem, IsraelMD1980

    Collapse Overview 
    Collapse Overview
    Research Interests
    - Fundamentals of innate immunity
    - TLR and the non-TLR activation pathways

    The research in my lab is focusing on the fundamentals of innate immunity. We study the Toll-like receptor (TLR) and the non-TLR activation pathways by which the host recognizes and responds to any microbial agent. We explore the consequences of this activation on antigen presentation by dendritic cells and its impact on priming of naïve CD4 and CD8 T cells as well as the generation of memory T cell responses.

    Using a similar strategy, we investigate the role of transient receptor potential (TRP) family members in inflammation. This approach to basic science helps us to develop vaccines against various infectious agents (e.g., HIV), tumors and allergic diseases (i.e., asthma). Some of the therapeutic approaches developed in our lab are already used in humans.

    Similarly, we explore the role of innate immunity in the inhibition of certain inflammatory conditions. In particular, we study the principles of host-commensal interaction in the G-I tract and explore how this interaction affects various inflammatory intestinal conditions and their human analogs such as inflammatory bowel disease and colitis-associated cancer.

    Collapse Research 
    Collapse Research Activities and Funding
    A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DC
    NIH/NHLBI R01HL141999Jan 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Control of mucosal immunity by Gas- vs Gai-linked GPCR signaling in dendritic cells
    NIH/NIAID U01AI125860Jun 6, 2016 - May 31, 2021
    Role: Principal Investigator
    The inductive role of Gs/Gi signaling in dendritic cell polarization and function
    NIH/NIAID R56AI110505Mar 10, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Th17 subsets: Differential roles in immune defense mechanisms at the G-I mucosa
    NIH/NIAID U01AI095623Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    The Impact of TLR on Intestinal Tumorigenesis
    NIH/NCI R21CA133702Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Mucosal adjuvants regulate inflammation and immunity
    NIH/NIAID R21AI083328Jun 5, 2009 - May 31, 2011
    Role: Principal Investigator
    The diverse contribution of TLR pathways to intestinal homeostasis
    NIH/NIAID R01AI068685Jul 1, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Mechanisms of CpG-Induced Inhibition of Allergic Asthma
    NIH/NIAID R01AI057709Sep 15, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Mechanisms of Tolerance Induction by Immunostimulatory *
    NIH/NHLBI R21HL079449Jul 12, 2004 - Jun 30, 2007
    Role: Principal Investigator
    TLR Ligand-Based Vaccines for SIV/HIV
    NIH/NIAID R01AI058743Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    ISS AS AN ADJUVANT FOR SIV/HIV-BASED VACCINE
    NIH/NIAID R21AI047078Apr 1, 2000 - Mar 31, 2003
    Role: Principal Investigator
    Critical Analysis of the Hygiene Hypothesis
    NIH/NIAID P01AI040682Sep 30, 1997 - Sep 29, 2002
    Role: Principal Investigator
    IMMUNE REGULATION BY INTRADERMAL GENE DELIVERY
    NIH/NIAID R01AI037305Sep 30, 1994 - Aug 31, 1997
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CCL2 mitigates cyclic AMP-suppressed Th2 immune response in human dendritic cells. Allergy. 2020 Aug; 75(8). Kim B, Yeon JW, Lee JH, Lee HJ, Byun J, Lee K, Raz E, Lee SH, Baek SK, Kim TH. PMID: 32191339.
      View in: PubMed   Mentions:    Fields:    
    2. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 Feb 04; 9. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. PMID: 32014112.
      View in: PubMed   Mentions: 1     Fields:    
    3. Dust mite-derived Der f 3 activates a pro-inflammatory program in airway epithelial cells via PAR-1 and PAR-2. Mol Immunol. 2019 05; 109:1-11. Li B, Zou Z, Meng F, Raz E, Huang Y, Tao A, Ai Y. PMID: 30836204.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Myeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis. Infect Immun. 2018 06; 86(6). Viriyakosol S, Walls L, Okamoto S, Raz E, Williams DL, Fierer J. PMID: 29610256.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. PMID: 28130546.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    6. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 09; 66(9):1584-1596. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. PMID: 27325418.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    7. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 05 17; 7:11551. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. PMID: 27187615.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    8. The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis. Oncotarget. 2016 Jan 05; 7(1):148-60. Samivel R, Kim DW, Son HR, Rhee YH, Kim EH, Kim JH, Bae JS, Chung YJ, Chung PS, Raz E, Mo JH. PMID: 26700618.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol. 2016 05; 38(3):309-19. Bertin S, Raz E. PMID: 26468011.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia. Exp Parasitol. 2015 Sep; 156:68-78. Dann SM, Manthey CF, Le C, Miyamoto Y, Gima L, Abrahim A, Cao AT, Hanson EM, Kolls JK, Raz E, Cong Y, Eckmann L. PMID: 26071205.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    11. [A novel role for the TRPV1 ion channel in CD4 T cell activation]. Med Sci (Paris). 2015 Feb; 31(2):135-6. Bertin S, Raz E. PMID: 25744258.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. PMID: 25731159.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    13. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. PMID: 25605931.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    14. TRPV1: Turning up the heat on intestinal tumorigenesis. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e975619. de Jong PR, Bertin S, Raz E. PMID: 27308393.
      View in: PubMed   Mentions:
    15. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    16. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3793-806. de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. PMID: 25083990.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    17. The immediate protective response to microbial challenge. Eur J Immunol. 2014 Sep; 44(9):2536-49. González-Navajas JM, Corr MP, Raz E. PMID: 24965684.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. STAT3: An Anti-Invasive Factor in Colorectal Cancer? Cancers (Basel). 2014 Jul 03; 6(3):1394-407. de Jong PR, Mo JH, Harris AR, Lee J, Raz E. PMID: 24995503.
      View in: PubMed   Mentions:
    19. Novel immune function for the TRPV1 channel in T lymphocytes. Channels (Austin). 2014; 8(6):479-80. Bertin S, de Jong PR, Jefferies WA, Raz E. PMID: 25530461.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis. Ann Rheum Dis. 2012 Oct; 71(10):1706-15. Zonneveld-Huijssoon E, van Wijk F, Roord S, Delemarre E, Meerding J, de Jager W, Klein M, Raz E, Albani S, Kuis W, Boes M, Prakken BJ. PMID: 22562976.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J Biol Chem. 2012 May 25; 287(22):18182-9. Lee J, Kim JC, Lee SE, Quinley C, Kim H, Herdman S, Corr M, Raz E. PMID: 22496368.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    22. Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Gastroenterology. 2012 Jul; 143(1):145-54. Lee SE, Li X, Kim JC, Lee J, González-Navajas JM, Hong SH, Park IK, Rhee JH, Raz E. PMID: 22475534.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    23. Divergent requirement for Gas and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012 Mar; 122(3):963-73. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. PMID: 22326954.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    24. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Jan 06; 12(2):125-35. González-Navajas JM, Lee J, David M, Raz E. PMID: 22222875.
      View in: PubMed   Mentions: 312     Fields:    Translation:Humans
    25. Autophagy suppresses interleukin-1ß (IL-1ß) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem. 2012 Feb 03; 287(6):4033-40. Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R, Raz E. PMID: 22167182.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    26. The Role of Plasmacytoid and Myeloid Dendritic Cells in Induction of Asthma in a Mouse Model and the Effect of a TLR9 Agonist on Dendritic Cells. Allergy Asthma Immunol Res. 2011 Jul; 3(3):199-204. Mo JH, Chung YJ, Hayashi T, Lee J, Raz E. PMID: 21738886.
      View in: PubMed   Mentions:
    27. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20; 207(13):2799-807. González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. PMID: 21115691.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    28. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. PMID: 20479237.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    29. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010 Jun; 16(6):665-70. Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E. PMID: 20473309.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    30. Retrosternal percutaneous tracheostomy: an approach for predictably impossible classic tracheostomy. Crit Care Res Pract. 2010; 2010:397270. Biderman P, Weinbroum AA, Rafaeli Y, Raz E, Porat E, Wiesel O, Szold O. PMID: 20981321.
      View in: PubMed   Mentions:
    31. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest. 2010 Feb; 120(2):570-81. González-Navajas JM, Fine S, Law J, Datta SK, Nguyen KP, Yu M, Corr M, Katakura K, Eckman L, Lee J, Raz E. PMID: 20051628.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    32. Mucosal immunity: aliment and ailments. Mucosal Immunol. 2010 Jan; 3(1):4-7. Raz E. PMID: 19890270.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    33. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009 Jul 15; 183(2):1346-59. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ. PMID: 19564341.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    34. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565. Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. PMID: 19203587.
      View in: PubMed   Mentions:    Fields:    
    35. The protective effects of type-1 interferon in models of intestinal inflammation. Adv Exp Med Biol. 2009; 633:1-6. Lee J, Abe K, Katakura K, Gonzalez-Navajas J, Raz E. PMID: 19209676.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    36. Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2008 May; 28(5):724. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. PMID: 18504811.
      View in: PubMed   Mentions:    Fields:    
    37. The "polarizing-tolerizing" mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol. 2008 Feb; 30(1):3-9. Lee J, Gonzales-Navajas JM, Raz E. PMID: 18026955.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18619-24. Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. PMID: 18003900.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    39. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17022-7. Abe K, Nguyen KP, Fine SD, Mo JH, Shen C, Shenouda S, Corr M, Jung S, Lee J, Eckmann L, Raz E. PMID: 17942668.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    40. Organ-specific regulation of innate immunity. Nat Immunol. 2007 Jan; 8(1):3-4. Raz E. PMID: 17179960.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    41. Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis. Curr Opin Gastroenterol. 2007 Jan; 23(1):27-31. Lee J, Mo JH, Shen C, Rucker AN, Raz E. PMID: 17133081.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    42. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006 Dec; 8(12):1327-36. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, Liu YT, Lee HK, Shen C, Cojocaru G, Shenouda S, Kagnoff M, Eckmann L, Ben-Neriah Y, Raz E. PMID: 17128265.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimalsCells
    43. TLR9-based immunotherapy for allergic disease. Am J Med. 2006 Oct; 119(10):897.e1-6. Hayashi T, Raz E. PMID: 17000223.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    44. Homeostatic effects of TLR9 signaling in experimental colitis. Ann N Y Acad Sci. 2006 Aug; 1072:351-5. Lee J, Rachmilewitz D, Raz E. PMID: 17057215.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    45. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul; 25(1):143-52. Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E. PMID: 16860763.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCellsPHPublic Health
    46. Immunostimulatory oligonucleotides inhibit colonic proinflammatory cytokine production in ulcerative colitis. Inflamm Bowel Dis. 2006 May; 12(5):339-45. Rachmilewitz D, Karmeli F, Shteingart S, Lee J, Takabayashi K, Raz E. PMID: 16670522.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    47. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2006 Apr; 24(4):475-87. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. PMID: 16618605.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    48. Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis. Am J Rhinol. 2006 Mar-Apr; 20(2):212-8. Mo JH, Park SW, Rhee CS, Takabayashi K, Lee SS, Quan SH, Kim IS, Min IY, Raz E, Lee CH. PMID: 16686392.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    49. Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA. J Allergy Clin Immunol. 2006 Mar; 117(3):618-25. Cho JY, Miller M, McElwain K, McElwain S, Shim JY, Raz E, Broide DH. PMID: 16522462.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    50. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1828-33. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. PMID: 16446426.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    51. Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice. J Allergy Clin Immunol. 2006 Mar; 117(3):597-603. Lee SY, Cho JY, Miller M, McElwain K, McElwain S, Sriramarao P, Raz E, Broide DH. PMID: 16522459.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    52. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7. Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. PMID: 16306937.
      View in: PubMed   Mentions: 293     Fields:    Translation:AnimalsCells
    53. Molecular and cellular mechanisms of protective immunity to coccidioidomycosis. Vaccine. 2006 Jan 23; 24(4):495-500. Kirkland TN, Raz E, Datta SK. PMID: 16181709.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    54. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 01; 45(2):303-10. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG. PMID: 16002269.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    55. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 01; 174(9):5864-73. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. PMID: 15843591.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    56. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005 Mar; 115(3):695-702. Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E. PMID: 15765149.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    57. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol. 2004 Dec 15; 173(12):7556-64. Youn CJ, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. PMID: 15585883.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. Toll-like receptor ligands: hygiene, atopy and therapeutic implications. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):555-61. Horner AA, Redecke V, Raz E. PMID: 15640699.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsPHPublic Health
    59. Induction of antigen cross-presentation by Toll-like receptors. Springer Semin Immunopathol. 2005 Jan; 26(3):247-55. Datta SK, Raz E. PMID: 15609002.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    60. Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis. Immunology. 2004 Sep; 113(1):106-13. Rhee CS, Libet L, Chisholm D, Takabayashi K, Baird S, Bigby TD, Lee CH, Horner AA, Raz E. PMID: 15312141.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    61. Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. Am J Respir Crit Care Med. 2004 Dec 01; 170(11):1153-7. Fanucchi MV, Schelegle ES, Baker GL, Evans MJ, McDonald RJ, Gershwin LJ, Raz E, Hyde DM, Plopper CG, Miller LA. PMID: 15306532.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    62. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. PMID: 15254594.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    63. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem. 2004 Aug 06; 279(32):33071-8. Wu CC, Lee J, Raz E, Corr M, Carson DA. PMID: 15184382.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    64. Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications. Immunol Rev. 2004 Jun; 199:217-26. Datta SK, Cho HJ, Takabayashi K, Horner AA, Raz E. PMID: 15233737.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    65. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004 Mar 01; 172(5):2739-43. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. PMID: 14978071.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    66. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 2004 Feb; 126(2):520-8. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E. PMID: 14762789.
      View in: PubMed   Mentions: 215     Fields:    Translation:AnimalsCells
    67. Do microbes influence the pathogenesis of allergic diseases? Building the case for Toll-like receptor ligands. Curr Opin Immunol. 2003 Dec; 15(6):614-9. Horner AA, Raz E. PMID: 14630193.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    68. The therapeutic potential of antigen-oligonucleotide conjugates. Ann N Y Acad Sci. 2003 Dec; 1002:105-11. Datta SK, Takabayashi K, Raz E. PMID: 14751828.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsPHPublic Health
    69. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 2004 May; 30(5):651-61. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. PMID: 14617508.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    70. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol. 2003 Nov 01; 171(9):4860-7. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide DH. PMID: 14568966.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    71. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol. 2003 Jun; 28(6):655-63. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide DH. PMID: 12760963.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    72. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6646-51. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. PMID: 12738885.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    73. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol. 2003 Apr 15; 170(8):4102-10. Datta SK, Redecke V, Prilliman KR, Takabayashi K, Corr M, Tallant T, DiDonato J, Dziarski R, Akira S, Schoenberger SP, Raz E. PMID: 12682240.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    74. Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr Opin Allergy Clin Immunol. 2002 Dec; 2(6):547-51. Spiegelberg HL, Horner AA, Takabayashi K, Raz E. PMID: 14752340.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    75. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J Allergy Clin Immunol. 2002 Nov; 110(5):706-12. Horner AA, Raz E. PMID: 12417878.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsPHPublic Health
    76. Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines. Vaccine. 2002 Sep 10; 20(27-28):3342-54. Joseph A, Louria-Hayon I, Plis-Finarov A, Zeira E, Zakay-Rones Z, Raz E, Hayashi T, Takabayashi K, Barenholz Y, Kedar E. PMID: 12213404.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    77. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol. 2002 Sep; 110(3):413-20. Horner AA, Takabayashi K, Beck L, Sharma B, Zubeldia J, Baird S, Tuck S, Libet L, Spiegelberg HL, Liu FT, Raz E. PMID: 12209088.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    78. DNA-based vaccines for allergic disease. Expert Rev Vaccines. 2002 Aug; 1(2):169-77. Spiegelberg HL, Takabayashi K, Beck L, Raz E. PMID: 12901556.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    79. Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness. Vaccine. 2002 Jul 26; 20(23-24):3023-33. Miller M, Cho JY, Baek KJ, Castaneda D, Nayar J, Rodriguez M, Roman M, Raz E, Broide DH. PMID: 12126916.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    80. IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol. 2002 May 15; 168(10):4907-13. Cho HJ, Hayashi T, Datta SK, Takabayashi K, Van Uden JH, Horner A, Corr M, Raz E. PMID: 11994440.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    81. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology. 2002 May; 122(5):1428-41. Rachmilewitz D, Karmeli F, Takabayashi K, Hayashi T, Leider-Trejo L, Lee J, Leoni LM, Raz E. PMID: 11984528.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    82. DNA-based approaches to the treatment of allergies. Curr Opin Mol Ther. 2002 Feb; 4(1):64-71. Spiegelberg HL, Raz E. PMID: 11883696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    83. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. PMID: 11751945.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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