Wei Ying

Title(s)Assistant Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4890-7256 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    UCSD2018  - 2023NIDDK K99/R00 award
    UCSD2016  - 2018American Heart Association Postdoctoral Fellowship
    Texas A&M2013  - 2015American Heart Association Predoctoral Fellowship

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    The mechanisms underlying maternal obesity-induced microbial DNA accumulation in fetus and offspring metabolic abnormalities
    NIH R21HD107516Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Mechanisms by which hepatocyte extracellular miRNAs mediate peripheral insulin sensitivity
    NIH R01DK125560Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Adipose tissue macrophages secrete exosome-miRs as paracrine/endocrine molecules to directly modulate insulin target cell function in response to obesity
    NIH R00DK115998Sep 1, 2020 - Aug 31, 2023
    Role: Principal Investigator
    Adipose tissue macrophages secrete exosome-miRs as paracrine/endocrine molecules to directly modulate insulin target cell function in response to obesity
    NIH K99DK115998Jul 12, 2018 - Jul 11, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 Jul 05. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38969830.
      View in: PubMed   Mentions:    Fields:    
    2. Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 Apr 11. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38605183.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance. Hepatology. 2024 Mar 08. Gao H, Rocha KCE, Jin Z, Kumar D, Zhang D, Wang K, Das M, Farrell A, Truong T, Tekin Y, Jung HS, Kempf J, Webster NJG, Ying W. PMID: 38456794.
      View in: PubMed   Mentions:    Fields:    
    4. Exosome-Mediated Impact on Systemic Metabolism. Annu Rev Physiol. 2024 Feb 12; 86:225-253. Cunha E Rocha K, Ying W, Olefsky JM. PMID: 38345906.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart. Front Immunol. 2023; 14:1216344. Gao H, Wang K, Suarez JA, Jin Z, Rocha KCE, Zhang D, Farrell A, Truong T, Tekin Y, Tan B, Jung HS, Kempf J, Mahata SK, Dillmann WH, Suarez J, Ying W. PMID: 37520546; PMCID: PMC10373503.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes. Front Endocrinol (Lausanne). 2022; 13:1037465. Liu MA, Shahabi S, Jati S, Tang K, Gao H, Jin Z, Miller W, Meunier FA, Ying W, van den Bogaart G, Ghosh G, Mahata SK. PMID: 36440192; PMCID: PMC9691654.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 08 02; 34(8):1201-1213.e5. Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. PMID: 35921818; PMCID: PMC9365100.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    10. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab. 2022 07 05; 34(7):978-990.e4. Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky JM. PMID: 35700738; PMCID: PMC9262870.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    11. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    12. Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf). 2022 07; 235(3):e13827. Luo Z, Ji Y, Zhang D, Gao H, Jin Z, Yang M, Ying W. PMID: 35500155; PMCID: PMC9335517.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice. J Am Heart Assoc. 2022 02 15; 11(4):e024561. Gao H, Jin Z, Tang K, Ji Y, Suarez J, Suarez JA, Cunha E Rocha K, Zhang D, Dillmann WH, Mahata SK, Ying W. PMID: 35112881; PMCID: PMC9245808.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    14. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 01 28; 13(1):565. Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. PMID: 35091566; PMCID: PMC8799656.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    15. Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles. Cells. 2021 09 17; 10(9). Gao H, Luo Z, Jin Z, Ji Y, Ying W. PMID: 34572101; PMCID: PMC8472266.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    16. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 09 07; 33(9):1744-1762. Isaac R, Reis FCG, Ying W, Olefsky JM. PMID: 34496230; PMCID: PMC8428804.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansCells
    17. Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 09; 3(9):1163-1174. Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. PMID: 34489604; PMCID: PMC8460610.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    18. Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiol (Oxf). 2021 06; 232(2):e13655. Muntjewerff EM, Tang K, Lutter L, Christoffersson G, Nicolasen MJT, Gao H, Katkar GD, Das S, Ter Beest M, Ying W, Ghosh P, El Aidy S, Oldenburg B, van den Bogaart G, Mahata SK. PMID: 33783968; PMCID: PMC8341099.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 05 05; 77(5):1670-1682. Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. PMID: 33826401; PMCID: PMC8116433.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    20. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab. 2021 04 06; 33(4):781-790.e5. Ying W, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C, Olefsky JM. PMID: 33450179; PMCID: PMC8035248.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    21. CRIg+ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance. Gastroenterology. 2021 02; 160(3):863-874. Luo Z, Ji Y, Gao H, Gomes Dos Reis FC, Bandyopadhyay G, Jin Z, Ly C, Chang YJ, Zhang D, Kumar D, Ying W. PMID: 33152356; PMCID: PMC7878308.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    22. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat Rev Endocrinol. 2020 02; 16(2):81-90. Ying W, Fu W, Lee YS, Olefsky JM. PMID: 31836875; PMCID: PMC8315273.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    23. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 07; 68(7):1415-1426. Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. PMID: 31010956; PMCID: PMC6609982.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    24. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478; PMCID: PMC6701710.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    25. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. PMID: 29432123; PMCID: PMC6463753.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    26. Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond). 2018 04; 42(4):728-736. Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O. PMID: 29089614; PMCID: PMC6055936.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    27. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017; 171(2):372-384. Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM.
    28. IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Endocrinology. 2017 09 01; 158(9):2837-2847. Li C, Ying W, Huang Z, Brehm T, Morin A, Vella AT, Zhou B. PMID: 28645193; PMCID: PMC5659664.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Diabetic Cardiomyopathy: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2017; 8:72. Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK. PMID: 28439258; PMCID: PMC5384479.
      View in: PubMed   Mentions: 35     Fields:    
    30. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 01; 127(3):1019-1030. Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. PMID: 28192375; PMCID: PMC5330737.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    31. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. PMID: 27814523; PMCID: PMC5179329.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    32. Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice. PLoS One. 2016; 11(6):e0157543. Shi L, Kim AJ, Chang RC, Chang JY, Ying W, Ko ML, Zhou B, Ko GY. PMID: 27304911; PMCID: PMC4909316.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. miR-150 regulates insulin sensitivity through modulation of B cell function: A novel paradigm of the development of insulin resistance. Scientific Reports. 2016. Ying W, Tseng A, Chang C, Wang H, Lin Y, Kanameni S, Brehm T, Morin, A, Jones B, Splawn T, Brehm T, Morin A, Criscitiello M, Golding M, Bazer F, Safe S, Zhou B.
    34. MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation. J Clin Invest. 2015 Nov 02; 125(11):4149-59. Ying W, Tseng A, Chang RC, Morin A, Brehm T, Triff K, Nair V, Zhuang G, Song H, Kanameni S, Wang H, Golding MC, Bazer FW, Chapkin RS, Safe S, Zhou B. PMID: 26436647; PMCID: PMC4639972.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    35. The many faces of interferon tau. Amino Acids. 2015 Mar; 47(3):449-60. Bazer FW, Ying W, Wang X, Dunlap KA, Zhou B, Johnson GA, Wu G. PMID: 25557050.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    36. Pregnancy-secreted Acid phosphatase, uteroferrin, enhances fetal erythropoiesis. Endocrinology. 2014 Nov; 155(11):4521-30. Ying W, Wang H, Bazer FW, Zhou B. PMID: 25093463; PMCID: PMC4197981.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular Diseases. Cells. 2014 Jul 10; 3(3):702-12. Chang RC, Ying W, Bazer FW, Zhou B. PMID: 25014161; PMCID: PMC4197627.
      View in: PubMed   Mentions: 16     Fields:    
    38. Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization. PLoS One. 2014; 9(6):e98835. Ying W, Kanameni S, Chang CA, Nair V, Safe S, Bazer FW, Zhou B. PMID: 24905566; PMCID: PMC4048269.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    39. Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses. Biol Reprod. 2014 Apr; 90(4):84. Wang X, Ying W, Dunlap KA, Lin G, Satterfield MC, Burghardt RC, Wu G, Bazer FW. PMID: 24648395.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    40. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Mol Cancer Res. 2013 Aug; 11(8):912-22. Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B. PMID: 23604034.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    41. Handbook of Nutrition, Diet, and Epigenetics. Zhou, B, Ying, W, Li, C, Vella, AT. View Publication.
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