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Yuko Kono

TitleClinical Professor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address200 W. Arbor Drive #8413
San Diego CA 92103
Phone619-543-2061
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kielar AZ, Chernyak V, Bashir MR, Do RK, Fowler KJ, Mitchell DG, Cerny M, Elsayes KM, Santillan C, Kamaya A, Kono Y, Sirlin CB, Tang A. LI-RADS 2017: An update. J Magn Reson Imaging. 2018 Jun; 47(6):1459-1474. PMID: 29626376.
      View in: PubMed
    2. Lyshchik A, Kono Y, Dietrich CF, Jang HJ, Kim TK, Piscaglia F, Vezeridis A, Willmann JK, Wilson SR. Contrast-enhanced ultrasound of the liver: technical and lexicon recommendations from the ACR CEUS LI-RADS working group. Abdom Radiol (NY). 2018 Apr; 43(4):861-879. PMID: 29151131.
      View in: PubMed
    3. Ikeda S, Tsigelny IF, Skjevik ÅA, Kono Y, Mendler M, Kuo A, Sicklick JK, Heestand G, Banks KC, Talasaz A, Lanman RB, Lippman S, Kurzrock R. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. Oncologist. 2018 May; 23(5):586-593. PMID: 29487225.
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    4. Tanabe H, Higuchi Y, Yuan JH, Hashiguchi A, Yoshimura A, Ishihara S, Nozuma S, Okamoto Y, Matsuura E, Ishiura H, Mitsui J, Takashima R, Kokubun N, Maeda K, Asano Y, Sunami Y, Kono Y, Ishigaki Y, Yanamoto S, Fukae J, Kida H, Morita M, Tsuji S, Takashima H. Clinical and genetic features of Charcot-Marie-Tooth disease 2F and hereditary motor neuropathy 2B in Japan. J Peripher Nerv Syst. 2018 Mar; 23(1):40-48. PMID: 29381233.
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    5. Dietrich CF, Averkiou M, Nielsen MB, Barr RG, Burns PN, Calliada F, Cantisani V, Choi B, Chammas MC, Clevert DA, Claudon M, Correas JM, Cui XW, Cosgrove D, D'Onofrio M, Dong Y, Eisenbrey J, Fontanilla T, Gilja OH, Ignee A, Jenssen C, Kono Y, Kudo M, Lassau N, Lyshchik A, Franca Meloni M, Moriyasu F, Nolsøe C, Piscaglia F, Radzina M, Saftoiu A, Sidhu PS, Sporea I, Schreiber-Dietrich D, Sirlin CB, Stanczak M, Weskott HP, Wilson SR, Willmann JK, Kim TK, Jang HJ, Vezeridis A, Westerway S. How to perform Contrast-Enhanced Ultrasound (CEUS). Ultrasound Int Open. 2018 Jan; 4(1):E2-E15. PMID: 29423461.
      View in: PubMed
    6. Wilson SR, Lyshchik A, Piscaglia F, Cosgrove D, Jang HJ, Sirlin C, Dietrich CF, Kim TK, Willmann JK, Kono Y. CEUS LI-RADS: algorithm, implementation, and key differences from CT/MRI. Abdom Radiol (NY). 2018 Jan; 43(1):127-142. PMID: 28819825.
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    7. Yasuda Y, Hattori Y, Tohnai R, Ito S, Kawa Y, Kono Y, Urata Y, Nogami M, Takenaka D, Negoro S, Satouchi M. The safety and efficacy of carboplatin plus nanoparticle albumin-bound paclitaxel in the treatment of non-small cell lung cancer patients with interstitial lung disease. Jpn J Clin Oncol. 2018 Jan 01; 48(1):89-93. PMID: 29036303.
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    8. Santillan C, Fowler K, Kono Y, Chernyak V. LI-RADS major features: CT, MRI with extracellular agents, and MRI with hepatobiliary agents. Abdom Radiol (NY). 2018 Jan; 43(1):75-81. PMID: 28828680.
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    9. Chernyak V, Tang A, Flusberg M, Papadatos D, Bijan B, Kono Y, Santillan C. LI-RADS® ancillary features on CT and MRI. Abdom Radiol (NY). 2018 Jan; 43(1):82-100. PMID: 28647768.
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    10. Yasuda Y, Urata Y, Tohnai R, Ito S, Kawa Y, Kono Y, Hattori Y, Tsuda M, Sakuma T, Negoro S, Satouchi M. Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer. Intern Med. 2018 May 01; 57(9):1269-1272. PMID: 29279482.
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    11. Fetzer DT, Rodgers SK, Harris AC, Kono Y, Wasnik AP, Kamaya A, Sirlin C. Screening and Surveillance of Hepatocellular Carcinoma: An Introduction to Ultrasound Liver Imaging Reporting and Data System. Radiol Clin North Am. 2017 Nov; 55(6):1197-1209. PMID: 28991560.
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    12. Elsayes KM, Hooker JC, Agrons MM, Kielar AZ, Tang A, Fowler KJ, Chernyak V, Bashir MR, Kono Y, Do RK, Mitchell DG, Kamaya A, Hecht EM, Sirlin CB. 2017 Version of LI-RADS for CT and MR Imaging: An Update. Radiographics. 2017 Nov-Dec; 37(7):1994-2017. PMID: 29131761.
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    13. Ta CN, Kono Y, Eghtedari M, Oh YT, Robbin ML, Barr RG, Kummel AC, Mattrey RF. Focal Liver Lesions: Computer-aided Diagnosis by Using Contrast-enhanced US Cine Recordings. Radiology. 2018 03; 286(3):1062-1071. PMID: 29072980.
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    14. Kim TK, Noh SY, Wilson SR, Kono Y, Piscaglia F, Jang HJ, Lyshchik A, Dietrich CF, Willmann JK, Vezeridis A, Sirlin CB. Contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) 2017 - a review of important differences compared to the CT/MRI system. Clin Mol Hepatol. 2017 Dec; 23(4):280-289. PMID: 28911220.
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    15. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. PMID: 28628033.
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    16. Piscaglia F, Wilson SR, Lyshchik A, Cosgrove D, Dietrich CF, Jang HJ, Kim TK, Salvatore V, Willmann JK, Sirlin CB, Kono Y. American College of Radiology Contrast Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) for the diagnosis of Hepatocellular Carcinoma: a pictorial essay. Ultraschall Med. 2017 Jun; 38(3):320-324. PMID: 28329875.
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    17. Kono Y, Lyshchik A, Cosgrove D, Dietrich CF, Jang HJ, Kim TK, Piscaglia F, Willmann JK, Wilson SR, Santillan C, Kambadakone A, Mitchell D, Vezeridis A, Sirlin CB. Contrast Enhanced Ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS®): the official version by the American College of Radiology (ACR). Ultraschall Med. 2017 Jan; 38(1):85-86. PMID: 28249328.
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    18. Wang M, Sanda M, Comunale MA, Herrera H, Swindell C, Kono Y, Singal AG, Marrero J, Block T, Goldman R, Mehta A. Changes in the Glycosylation of Kininogen and the Development of a Kininogen-Based Algorithm for the Early Detection of HCC. Cancer Epidemiol Biomarkers Prev. 2017 05; 26(5):795-803. PMID: 28223431.
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    19. Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma. Mol Cancer Ther. 2016 11; 15(11):2553-2562. PMID: 27496136.
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    20. Wang M, Comunale MA, Herrera H, Betesh L, Kono Y, Mehta A. Identification of IgM as a contaminant in lectin-FLISA assays for HCC detection. Biochem Biophys Res Commun. 2016 07 29; 476(3):140-5. PMID: 27181357.
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    21. Tanabe M, Kanki A, Wolfson T, Costa EA, Mamidipalli A, Ferreira MP, Santillan C, Middleton MS, Gamst AC, Kono Y, Kuo A, Sirlin CB. Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging. Radiology. 2016 Oct; 281(1):129-39. PMID: 27115054.
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    22. Kono Y, Wakabayashi T, Kobayashi M, Ohashi T, Eto Y, Ida H, Iguchi Y. Characteristics of Cerebral Microbleeds in Patients with Fabry Disease. J Stroke Cerebrovasc Dis. 2016 Jun; 25(6):1320-5. PMID: 26987491.
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    23. Lin SC, Ang B, Hernandez C, Bettencourt R, Jain R, Salotti J, Richards L, Kono Y, Bhatt A, Aryafar H, Lin GY, Valasek MA, Sirlin CB, Brouha S, Loomba R. Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial. Therap Adv Gastroenterol. 2016 Mar; 9(2):152-61. PMID: 26929777; PMCID: PMC4749859.
    24. Yokoo T, Wolfson T, Iwaisako K, Peterson MR, Mani H, Goodman Z, Changchien C, Middleton MS, Gamst AC, Mazhar SM, Kono Y, Ho SB, Sirlin CB. Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T. Biomed Res Int. 2015; 2015:387653. PMID: 26421287; PMCID: PMC4569760.
    25. Kanda M, Ota E, Fukuda H, Miyauchi S, Gilmour S, Kono Y, Nakagama E, Murashima S, Shibuya K. Effectiveness of community-based health services by nurse practitioners: protocol for a systematic review and meta-analysis. BMJ Open. 2015 Jun 23; 5(6):e006670. PMID: 26105030; PMCID: PMC4480018.
    26. Mitsumura H, Miyagawa S, Komatsu T, Hirai T, Kono Y, Iguchi Y. Clinical Characteristics of Intracranial Reversed Vertebral Artery Flow Evaluated by Transcranial Color Flow Imaging. J Stroke Cerebrovasc Dis. 2015 Aug; 24(8):1775-80. PMID: 26047598.
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    27. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. PMID: 25482832; PMCID: PMC4407930.
    28. Ta CN, Eghtedari M, Mattrey RF, Kono Y, Kummel AC. 2-tier in-plane motion correction and out-of-plane motion filtering for contrast-enhanced ultrasound. Invest Radiol. 2014 Nov; 49(11):707-19. PMID: 24901545; PMCID: PMC4184933.
    29. Kono Y, Sengoku R, Mitsumura H, Bono K, Sakuta K, Yamasaki M, Mochio S, Iguchi Y. Clinical characteristics associated with corticospinal tract hyperintensity on magnetic resonance imaging in patients with amyotrophic lateral sclerosis. Clin Neurol Neurosurg. 2014 Dec; 127:1-4. PMID: 25306412.
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    30. Joshi K, Mendler M, Gish R, Loomba R, Kuo A, Patton H, Kono Y. Hepatocellular carcinoma surveillance: a national survey of current practices in the USA. Dig Dis Sci. 2014 Dec; 59(12):3073-7. PMID: 25027206.
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    31. Smorodinsky E, Ansdell DS, Foster ZW, Mazhar SM, Cruite I, Wolfson T, Sugay SB, Iussich G, Shiehmorteza M, Kono Y, Kuo A, Sirlin CB. Risk of nephrogenic systemic fibrosis is low in patients with chronic liver disease exposed to gadolinium-based contrast agents. J Magn Reson Imaging. 2015 May; 41(5):1259-67. PMID: 24811860.
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    32. Kono Y, Matsushima E, Uji M. Psychometric properties of the 25-item Work Limitations Questionnaire in Japan: factor structure, validity, and reliability in information and communication technology company employees. J Occup Environ Med. 2014 Feb; 56(2):184-8. PMID: 24451614.
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    33. Takahashi Y, Zhang W, Sameshima K, Kuroki C, Matsumoto A, Sunanaga J, Kono Y, Sakurai T, Kanmura Y, Kuwaki T. Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice. J Physiol. 2013 Nov 15; 591(22):5623-43. PMID: 23959674; PMCID: PMC3853500.
    34. Cui W, Tavri S, Benchimol MJ, Itani M, Olson ES, Zhang H, Decyk M, Ramirez RG, Barback CV, Kono Y, Mattrey RF. Neural progenitor cells labeling with microbubble contrast agent for ultrasound imaging in vivo. Biomaterials. 2013 Jul; 34(21):4926-35. PMID: 23578557; PMCID: PMC3742341.
    35. Rose SC, Kikolski SG, Gish RG, Kono Y, Loomba R, Hemming AW, Wallace MJ. Society of Interventional Radiology critique and commentary on the Cochrane report on transarterial chemoembolization. Hepatology. 2013 Apr; 57(4):1675-6. PMID: 22886617.
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    36. Eghtedari M, Sicklick J, Kono Y, Peterson MR, Santillan CS. Unusual imaging profile of a solitary splenic lymphangioma. Acta Radiol Short Rep. 2012; 1(8). PMID: 23986850; PMCID: PMC3738359.
    37. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. PMID: 22431131; PMCID: PMC3400720.
    38. Leen E, Averkiou M, Arditi M, Burns P, Bokor D, Gauthier T, Kono Y, Lucidarme O. Dynamic contrast enhanced ultrasound assessment of the vascular effects of novel therapeutics in early stage trials. Eur Radiol. 2012 Jul; 22(7):1442-50. PMID: 22302501.
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    39. Liberman A, Martinez HP, Ta CN, Barback CV, Mattrey RF, Kono Y, Blair SL, Trogler WC, Kummel AC, Wu Z. Hollow silica and silica-boron nano/microparticles for contrast-enhanced ultrasound to detect small tumors. Biomaterials. 2012 Jul; 33(20):5124-9. PMID: 22498299; PMCID: PMC3588157.
    40. Ta CN, Kono Y, Barback CV, Mattrey RF, Kummel AC. Automating tumor classification with pixel-by-pixel contrast-enhanced ultrasound perfusion kinetics. J Vac Sci Technol B Nanotechnol Microelectron. 2012 Mar; 30(2):2C103. PMID: 23616934.
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    41. Kono Y, Omoto S, Sengoku R, Yaguchi H, Sonoo M, Inoue K, Mochio S. Multifocal conduction block in a patient with sarcoid neuropathy: successful treatment with intravenous immunoglobulin. Intern Med. 2013; 52(9):999-1002. PMID: 23648721.
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    42. Minami Y, Okumura N, Yamamoto N, Tsuji N, Kono Y, Kudo M. Quantification of tumor vascularity with contrast-enhanced ultrasound for early response of transcatheter arterial chemoembolization for hepatocellular carcinoma: a report of three cases. J Med Ultrason (2001). 2012 Jan; 39(1):15-9. PMID: 27278700.
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    43. Kurosawa T, Kono Y, Nagahata H. Ultrasonographic evaluation of thymus in Holstein calves and Heifers and its diagnostic application. J Vet Med Sci. 2011 Nov; 73(11):1433-6. PMID: 21737968.
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    44. Yokoo T, Shiehmorteza M, Hamilton G, Wolfson T, Schroeder ME, Middleton MS, Bydder M, Gamst AC, Kono Y, Kuo A, Patton HM, Horgan S, Lavine JE, Schwimmer JB, Sirlin CB. Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. Radiology. 2011 Mar; 258(3):749-59. PMID: 21212366; PMCID: PMC3042639.
    45. Martinez HP, Kono Y, Blair SL, Sandoval S, Wang-Rodriguez J, Mattrey RF, Kummel AC, Trogler WC. Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors. Medchemcomm. 2010 Oct; 1(4):266-270. PMID: 21841967.
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    46. Agemy L, Sugahara KN, Kotamraju VR, Gujraty K, Girard OM, Kono Y, Mattrey RF, Park JH, Sailor MJ, Jimenez AI, Cativiela C, Zanuy D, Sayago FJ, Aleman C, Nussinov R, Ruoslahti E. Nanoparticle-induced vascular blockade in human prostate cancer. Blood. 2010 Oct 14; 116(15):2847-56. PMID: 20587786; PMCID: PMC2974592.
    47. Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, Jahangeer S, Nakamura S, Nishimura Y. Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. Pulm Pharmacol Ther. 2010 Feb; 23(1):36-42. PMID: 19835973.
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    48. Faria SC, Ganesan K, Mwangi I, Shiehmorteza M, Viamonte B, Mazhar S, Peterson M, Kono Y, Santillan C, Casola G, Sirlin CB. MR imaging of liver fibrosis: current state of the art. Radiographics. 2009 Oct; 29(6):1615-35. PMID: 19959511.
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    49. Hamilton G, Middleton MS, Bydder M, Yokoo T, Schwimmer JB, Kono Y, Patton HM, Lavine JE, Sirlin CB. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging. 2009 Jul; 30(1):145-52. PMID: 19557733; PMCID: PMC2982807.
    50. Snyder CS, Kaushal S, Kono Y, Tran Cao HS, Hoffman RM, Bouvet M. Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer. BMC Cancer. 2009 Apr 08; 9:106. PMID: 19351417; PMCID: PMC2679761.
    51. Kuramoto E, Nishiuma T, Kobayashi K, Yamamoto M, Kono Y, Funada Y, Kotani Y, Sisson TH, Simon RH, Nishimura Y. Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model. Am J Physiol Lung Cell Mol Physiol. 2009 Mar; 296(3):L337-46. PMID: 19098125.
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    52. Sakashita A, Nishimura Y, Nogami M, Kuramoto E, Kono Y, Yamamoto M, Tamao N, Ohtera H, Kobayashi K, Funada Y, Nishiuma T, Kotani Y, Ohno Y. Diffuse periairway thickening in patients with Mikulicz disease. J Thorac Imaging. 2008 Aug; 23(3):213-5. PMID: 18728553.
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    53. Shen W, Niu Y, Mattrey RF, Fournier A, Corbeil J, Kono Y, Stuhmiller JH. Development and validation of subject-specific finite element models for blunt trauma study. J Biomech Eng. 2008 Apr; 130(2):021022. PMID: 18412509.
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    54. Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M. Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):395-404. PMID: 17641298.
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    55. Kono Y, Lucidarme O, Choi SH, Rose SC, Hassanein TI, Alpert E, Mattrey RF. Contrast-enhanced ultrasound as a predictor of treatment efficacy within 2 weeks after transarterial chemoembolization of hepatocellular carcinoma. J Vasc Interv Radiol. 2007 Jan; 18(1 Pt 1):57-65. PMID: 17296705.
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    56. Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun; 239(3):730-9. PMID: 16714458.
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    57. Kono Y, Funada H, Urata K, Yosimura S, Kotani Y, Satouti M, Negoro S, Takada Y. [A case of malignant lymphoma diagnosed by thoracoscopy with local anesthesia]. Nihon Kokyuki Gakkai Zasshi. 2005 Oct; 43(10):622-5. PMID: 16285597.
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    58. Kono Y, Mattrey RF. Ultrasound of the liver. Radiol Clin North Am. 2005 Sep; 43(5):815-26, vii. PMID: 16098341.
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    59. Choi SH, Kono Y, Corbeil J, Lucidarme O, Mattrey RF. Model to quantify lymph node enhancement on indirect sonographic lymphography. AJR Am J Roentgenol. 2004 Aug; 183(2):513-7. PMID: 15269049.
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    60. Lien WW, Lee AH, Kono Y, Steinbach GC, Mattrey RF. Noninvasive estimation of the pressure gradient across stenoses using sonographic contrast: in vitro validation. J Ultrasound Med. 2004 May; 23(5):683-91. PMID: 15154536.
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    61. Lucidarme O, Nguyen T, Kono Y, Corbeil J, Choi SH, Varner J, Mattrey RF. Angiogenesis model for ultrasound contrast research: exploratory study. Acad Radiol. 2004 Jan; 11(1):4-12. PMID: 14746396.
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    62. Kono Y, Pinnell SP, Sirlin CB, Sparks SR, Georgy B, Wong W, Mattrey RF. Carotid arteries: contrast-enhanced US angiography--preliminary clinical experience. Radiology. 2004 Feb; 230(2):561-8. PMID: 14699188.
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    63. Lucidarme O, Kono Y, Corbeil J, Choi SH, Mattrey RF. Validation of ultrasound contrast destruction imaging for flow quantification. Ultrasound Med Biol. 2003 Dec; 29(12):1697-704. PMID: 14698337.
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    64. Kono Y, Steinbach GC, Peterson T, Schmid-Schönbein GW, Mattrey RF. Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: an intravital microscopy study in rats. Radiology. 2002 Jul; 224(1):253-7. PMID: 12091692.
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    65. Mattrey RF, Kono Y, Baker K, Peterson T. Sentinel lymph node imaging with microbubble ultrasound contrast material. Acad Radiol. 2002 May; 9 Suppl 1:S231-5. PMID: 12019877.
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