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Joseph Witztum

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0682
La Jolla CA 92093
Phone858-534-4347
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of Immune Mechanisms in Athersclerosis and Inflammation
    NIH/NHLBI P01HL088093Apr 1, 2007 - Apr 30, 2019
    Role: Principal Investigator
    Development of a Vaccine Approach to Inhibit Atherosclerosis
    NIH/NHLBI R01HL086559Feb 10, 2007 - Jan 31, 2013
    Role: Principal Investigator
    LIPID MAPS
    NIH/NIGMS U54GM069338Aug 12, 2003 - Jul 31, 2014
    Role: Co-Investigator
    Role of B-1 Lymphocytes in Athergenesis
    NIH/NHLBI R01HL069464Sep 30, 2001 - Jul 31, 2005
    Role: Principal Investigator
    Discovery and Development of Therapeutic Genes for CHF
    NIH P01HL066941Sep 29, 2000 - Jun 30, 2018
    Role: Co-Investigator
    B-LYMPHOCYTE MEDIATED IMMUNE MECHANISMS IN ATHEROGENESIS
    NIH/NHLBI R01HL064833Jun 1, 2000 - May 31, 2004
    Role: Principal Investigator
    SCOR in Molecular Medicine and Atherosclerosis
    NIH/NHLBI P50HL056989Apr 23, 1997 - Mar 31, 2008
    Role: Principal Investigator
    Anticardiolipin Antibodies and Oxidized Phospholipids
    NIH/NHLBI R01HL057505Jan 1, 1997 - Jul 31, 2006
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    APOLIPOPROTEIN E DEFICIENCY AND ATHEROSCLEROSIS
    NIH/NHLBI R01HL039608Jul 1, 1988 - Sep 29, 1991
    Role: Principal Investigator
    Experimental Endocrinology and Metabolism
    NIH/NIDDK T32DK007044Sep 15, 1978 - Mar 31, 2021
    Role: Principal Investigator
    SCOR IN ARTERIOSCLEROSIS
    NIH P50HL014197Dec 1, 1976 - Apr 30, 1997
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hegele RA, Berberich AJ, Ban MR, Wang J, Digenio A, Alexander VJ, D'Erasmo L, Arca M, Jones A, Bruckert E, Stroes ES, Bergeron J, Civeira F, Witztum J, Gaudet D. Clinical and biochemical features of different molecular etiologies of familial chylomicronemia. J Clin Lipidol. 2018 Apr 04. PMID: 29748148.
      View in: PubMed
    2. Crooke ST, Witztum J, Bennett CF, Baker BF. RNA-Targeted Therapeutics. Cell Metab. 2018 Apr 03; 27(4):714-739. PMID: 29617640.
      View in: PubMed
    3. Viney NJ, Yeang C, Yang X, Xia S, Witztum J, Tsimikas S. Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide. J Clin Lipidol. 2018 Mar 01. PMID: 29574075.
      View in: PubMed
    4. Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum J. Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 Mar 01; 200(5):1702-1717. PMID: 29378911.
      View in: PubMed
    5. Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum J, Mulder WJM, Pérez-Medina C, Tsimikas S. PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol. 2018 Jan 23; 71(3):321-335. PMID: 29348025.
      View in: PubMed
    6. Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum J, Danthi S, Olive M, Liu L. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018 Jan 16; 71(2):177-192. PMID: 29325642.
      View in: PubMed
    7. Naka KK, Bechlioullis A, Marini A, Sionis D, Vakalis K, Triantis G, Wilkins L, Rogus J, Kornman KS, Witztum J, Doucette-Stamm L, Michalis LK, Tsimikas S. Interleukin-1 genotypes modulate the long-term effect of lipoprotein(a) on cardiovascular events: The Ioannina Study. J Clin Lipidol. 2018 Mar - Apr; 12(2):338-347. PMID: 29310992.
      View in: PubMed
    8. Yin X, Baig F, Haudebourg E, Blankley RT, Gandhi T, Müller S, Reiter L, Hinterwirth H, Pechlaner R, Tsimikas S, Santer P, Willeit J, Kiechl S, Witztum J, Sullivan A, Mayr M. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 Dec; 10(6). PMID: 29237681.
      View in: PubMed
    9. Marcovina SM, Viney NJ, Hughes SG, Xia S, Witztum J, Tsimikas S. Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials. J Clin Lipidol. 2018 Jan - Feb; 12(1):122-129.e2. PMID: 29174389.
      View in: PubMed
    10. Hartikainen J, Hassinen I, Hedman A, Kivelä A, Saraste A, Knuuti J, Husso M, Mussalo H, Hedman M, Rissanen TT, Toivanen P, Heikura T, Witztum J, Tsimikas S, Ylä-Herttuala S. Adenoviral intramyocardial VEGF-D?N?C gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up. Eur Heart J. 2017 Sep 01; 38(33):2547-2555. PMID: 28903476.
      View in: PubMed
    11. Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum J, Tsimikas S. Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017 Jun; 2(3):229-240. PMID: 29147686.
      View in: PubMed
    12. Kamstrup PR, Hung MY, Witztum J, Tsimikas S, Nordestgaard BG. Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study. Arterioscler Thromb Vasc Biol. 2017 Aug; 37(8):1570-1578. PMID: 28572160.
      View in: PubMed
    13. Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, Witztum J, Crooke RM, Tsimikas S. Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides. N Engl J Med. 2017 07 20; 377(3):222-232. PMID: 28538111.
      View in: PubMed
    14. van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum J, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1206-1212. PMID: 28473441.
      View in: PubMed
    15. Prasad A, Clopton P, Ayers C, Khera A, de Lemos JA, Witztum J, Tsimikas S. Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1213-1221. PMID: 28473443.
      View in: PubMed
    16. Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, Abbas S, Majeed F, Akhtar S, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Mallick NH, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Frossard P, Tsimikas S, Witztum J, Marcovina S, Sandhu M, Rader DJ, Danesh J. Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2017 07; 5(7):524-533. PMID: 28408323.
      View in: PubMed
    17. Davidson M, Stevenson M, Hsieh A, Ahmad Z, Crowson C, Witztum J. The burden of familial chylomicronemia syndrome: interim results from the IN-FOCUS study. Expert Rev Cardiovasc Ther. 2017 May; 15(5):415-423. PMID: 28338353.
      View in: PubMed
    18. Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum J, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 Feb 21; 69(7):789-800. PMID: 28209220.
      View in: PubMed
    19. Crooke ST, Baker BF, Witztum J, Kwoh TJ, Pham NC, Salgado N, McEvoy BW, Cheng W, Hughes SG, Bhanot S, Geary RS. The Effects of 2'-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials. Nucleic Acid Ther. 2017 Jun; 27(3):121-129. PMID: 28145801.
      View in: PubMed
    20. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum J, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. PMID: 28002731.
      View in: PubMed
    21. Lee SR, Prasad A, Choi YS, Xing C, Clopton P, Witztum J, Tsimikas S. LPA Gene, Ethnicity, and Cardiovascular Events. Circulation. 2017 Jan 17; 135(3):251-263. PMID: 27831500.
      View in: PubMed
    22. Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum J, Stroes ES, Tsimikas S. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet. 2016 11 05; 388(10057):2239-2253. PMID: 27665230.
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    23. van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum J, Tsimikas S, Riksen NP, Stroes ES. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016 Aug 23; 134(8):611-24. PMID: 27496857; PMCID: PMC4995139 [Available on 08/23/17].
    24. Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum J, Esko JD. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 Aug 01; 126(8):2855-66. PMID: 27400128; PMCID: PMC4966320 [Available on 11/01/16].
    25. Duell PB, Santos RD, Kirwan BA, Witztum J, Tsimikas S, Kastelein JJP. Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia. J Clin Lipidol. 2016 Jul-Aug; 10(4):1011-1021. PMID: 27578134.
      View in: PubMed
    26. Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum J, Tsimikas S. Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). J Clin Lipidol. 2016 May-Jun; 10(3):594-603. PMID: 27206947.
      View in: PubMed
    27. Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum J, Shiri-Sverdlov R, Nitschke L, Binder CJ. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep. 2016 Mar 15; 14(10):2348-61. PMID: 26947073; PMCID: PMC4802221.
    28. Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum J, McNamara CA. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):682-91. PMID: 26868208; PMCID: PMC4808436 [Available on 04/01/17].
    29. Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller YI, Witztum J, Tsimikas S. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results. J Lipid Res. 2016 Apr; 57(4):706-13. PMID: 26848137; PMCID: PMC4808774 [Available on 04/01/17].
    30. Witztum J, Ginsberg HN. Lipoprotein (a): Coming of Age at Last. J Lipid Res. 2016 Mar; 57(3):336-9. PMID: 26839334; PMCID: PMC4766984 [Available on 03/01/17].
    31. Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum J, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):456-65. PMID: 26821944; PMCID: PMC4853762 [Available on 03/01/17].
    32. Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum J, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis. J Am Coll Cardiol. 2015 Sep 15; 66(11):1236-1246. PMID: 26361154.
      View in: PubMed
    33. Witztum J. CEP Is an Important and Ubiquitous Oxidation Specific Epitope Recognized by Innate Pattern Recognition Receptors. Circ Res. 2015 Jul 31; 117(4):305-8. PMID: 26227873; PMCID: PMC4816067.
    34. Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum J, Brunzell JD, Kastelein JJ. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. N Engl J Med. 2015 Jul 30; 373(5):438-47. PMID: 26222559.
      View in: PubMed
    35. Glass CK, Witztum J. Daniel Steinberg, 1922-2015. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9791-2. PMID: 26209653; PMCID: PMC4538637.
    36. Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum J. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet. 2015 Oct 10; 386(10002):1472-83. PMID: 26210642.
      View in: PubMed
    37. Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum J, McNamara CA. B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17; 117(3):e28-39. PMID: 26082558.
      View in: PubMed
    38. Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum J, Remaley AT, Dong PD, Miller YI. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Dis Model Mech. 2015 Aug 01; 8(8):989-98. PMID: 26044956; PMCID: PMC4527288.
    39. Yeang C, Witztum J, Tsimikas S. 'LDL-C'?=?LDL-C?+?Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol. 2015 Jun; 26(3):169-78. PMID: 25943842.
      View in: PubMed
    40. Rao F, Schork AJ, Maihofer AX, Nievergelt CM, Marcovina SM, Miller ER, Witztum J, O'Connor DT, Tsimikas S. Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1704-11. PMID: 25953646; PMCID: PMC4483152.
    41. Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum J, Tsimikas S. Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: the TNT trial. J Am Coll Cardiol. 2015 Apr 07; 65(13):1286-1295. PMID: 25835440; PMCID: PMC4386070.
    42. Santos RD, Raal FJ, Catapano AL, Witztum J, Steinhagen-Thiessen E, Tsimikas S. Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):689-99. PMID: 25614280; PMCID: PMC4344404.
    43. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum J, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-36. PMID: 25598080; PMCID: PMC4340319.
    44. Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum J, Miller YI. SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL. Autophagy. 2015; 11(5):785-95. PMID: 25946330; PMCID: PMC4509444.
    45. Handa JT, Tagami M, Ebrahimi K, Leibundgut G, Janiak A, Witztum J, Tsimikas S. Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2015; 113:T5. PMID: 26538774; PMCID: PMC4601905.
    46. Fernandez JA, Deguchi H, Banka CL, Witztum J, Griffin JH. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):570-2. PMID: 25550205; PMCID: PMC4344393.
    47. Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum J, Lang IM, Binder CJ. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015 Feb; 56(2):440-8. PMID: 25525116; PMCID: PMC4306697.
    48. Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum J. Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014 Dec 04; 371(23):2200-6. PMID: 25470695.
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    49. Willeit P, Raschenberger J, Heydon EE, Tsimikas S, Haun M, Mayr A, Weger S, Witztum J, Butterworth AS, Willeit J, Kronenberg F, Kiechl S. Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. PLoS One. 2014; 9(11):e112483. PMID: 25390655; PMCID: PMC4229188.
    50. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum J, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. PMID: 25440058.
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    51. Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum J, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, Meisinger C, Gieger C, Müller-Nurasyid M, Peters A, Willeit J, Kiechl S. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):229-36. PMID: 25359861; PMCID: PMC4317265.
    52. Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum J, Tarling EJ. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 01; 193(11):5637-48. PMID: 25339664; PMCID: PMC4239162.
    53. Briley-Saebo K, Yeang C, Witztum J, Tsimikas S. Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. J Cardiovasc Transl Res. 2014 Nov; 7(8):719-36. PMID: 25297940; PMCID: PMC4233166.
    54. Willeit P, Kiechl S, Kronenberg F, Witztum J, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. J Am Coll Cardiol. 2014 Sep 02; 64(9):851-60. PMID: 25169167.
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    55. Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum J, Hartvigsen K. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. J Lipid Res. 2014 Oct; 55(10):2137-55. PMID: 25143462; PMCID: PMC4174006.
    56. Tsiantoulas D, Diehl CJ, Witztum J, Binder CJ. B cells and humoral immunity in atherosclerosis. Circ Res. 2014 May 23; 114(11):1743-56. PMID: 24855199; PMCID: PMC4066414.
    57. Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR. Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):976-84. PMID: 24651678; PMCID: PMC4091799.
    58. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum J, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. PMID: 24613321; PMCID: PMC4629781.
    59. Tsimikas S, Duff GW, Berger PB, Rogus J, Huttner K, Clopton P, Brilakis E, Kornman KS, Witztum J. Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a). J Am Coll Cardiol. 2014 May 06; 63(17):1724-34. PMID: 24530664; PMCID: PMC4008715.
    60. Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum J, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014 Apr 22; 129(16):1677-87. PMID: 24488984; PMCID: PMC3997655.
    61. Tse K, Gonen A, Sidney J, Ouyang H, Witztum J, Sette A, Tse H, Ley K. Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100. Front Immunol. 2013; 4:493. PMID: 24416033; PMCID: PMC3873602.
    62. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum J, Miller YI. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145. PMID: 24376657.
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    63. Hung MY, Witztum J, Tsimikas S. New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis. J Am Coll Cardiol. 2014 Feb 11; 63(5):478-80. PMID: 24161316.
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    64. Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum J, Bender TP, McNamara CA. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2771-9. PMID: 24115031.
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    65. Montano EN, Boullier A, Almazan F, Binder CJ, Witztum J, Hartvigsen K. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res. 2013 Nov; 54(11):3206-14. PMID: 23997238; PMCID: PMC3793625.
    66. Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum J, Haddad GG, Li AC. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704. PMID: 23990245; PMCID: PMC3882740.
    67. Witztum J, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol. 2014; 9:73-102. PMID: 23937439; PMCID: PMC3988528.
    68. Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum J, Koschinsky ML, Tsimikas S. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res. 2013 Oct; 54(10):2815-30. PMID: 23828779; PMCID: PMC3770094.
    69. Que X, Widhopf GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum J. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS One. 2013; 8(6):e65203. PMID: 23840319; PMCID: PMC3688726.
    70. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum J, Handel TM, Tsimikas S, Miller YI. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. PMID: 23667177; PMCID: PMC3679389.
    71. Leibundgut G, Witztum J, Tsimikas S. Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis. Curr Opin Pharmacol. 2013 Apr; 13(2):168-79. PMID: 23541680; PMCID: PMC3844667.
    72. Bertoia ML, Pai JK, Lee JH, Taleb A, Joosten MM, Mittleman MA, Yang X, Witztum J, Rimm EB, Tsimikas S, Mukamal KJ. Oxidation-specific biomarkers and risk of peripheral artery disease. J Am Coll Cardiol. 2013 May 28; 61(21):2169-79. PMID: 23541965; PMCID: PMC3756816.
    73. Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum J, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35. PMID: 23192915; PMCID: PMC3563836.
    74. Yoshida H, Shoda T, Yanai H, Ikewaki K, Kurata H, Ito K, Furutani N, Tada N, Witztum J, Tsimikas S. Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia. Atherosclerosis. 2013 Jan; 226(1):161-4. PMID: 23174369.
      View in: PubMed
    75. Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum J, Kiechl S. Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol. 2012 Nov 20; 60(21):2218-29. PMID: 23122790.
      View in: PubMed
    76. Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum J, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arterioscler Thromb Vasc Biol. 2012 Dec; 32(12):3066-75. PMID: 23023370; PMCID: PMC3610418.
    77. Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum J, VanNieuwenhze MS. Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. J Med Chem. 2012 Sep 27; 55(18):8178-82. PMID: 22934615; PMCID: PMC3465084.
    78. van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum J, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. J Lipid Res. 2012 Dec; 53(12):2773-90. PMID: 22969153; PMCID: PMC3494262.
    79. Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum J, Biswal S. Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke. Biochem Biophys Res Commun. 2012 Sep 21; 426(2):253-9. PMID: 22935414; PMCID: PMC3495329.
    80. Purushothaman KR, Purushothaman M, Levy AP, Lento PA, Evrard S, Kovacic JC, Briley-Saebo KC, Tsimikas S, Witztum J, Krishnan P, Kini A, Fayad ZA, Fuster V, Sharma SK, Moreno PR. Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis. J Am Coll Cardiol. 2012 Jul 10; 60(2):112-9. PMID: 22766337.
      View in: PubMed
    81. Visser ME, Witztum J, Stroes ES, Kastelein JJ. Antisense oligonucleotides for the treatment of dyslipidaemia. Eur Heart J. 2012 Jun; 33(12):1451-8. PMID: 22634577.
      View in: PubMed
    82. Arai K, Orsoni A, Mallat Z, Tedgui A, Witztum J, Bruckert E, Tselepis AD, Chapman MJ, Tsimikas S. Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia. J Lipid Res. 2012 Aug; 53(8):1670-8. PMID: 22628616; PMCID: PMC3540845.
    83. Leibundgut G, Arai K, Orsoni A, Yin H, Scipione C, Miller ER, Koschinsky ML, Chapman MJ, Witztum J, Tsimikas S. Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction. J Am Coll Cardiol. 2012 Apr 17; 59(16):1426-37. PMID: 22497821; PMCID: PMC3333481.
    84. Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum J, Binder CJ. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res. 2012 Jul; 53(7):1316-26. PMID: 22508944; PMCID: PMC3371243.
    85. Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum J, Melnick AM, Dent AL, Tangirala RK, Evans RM. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012 Apr 04; 15(4):554-62. PMID: 22465074; PMCID: PMC3367511.
    86. Briley-Saebo KC, Nguyen TH, Saeboe AM, Cho YS, Ryu SK, Volkova ER, Volkava E, Dickson S, Leibundgut G, Wiesner P, Weisner P, Green S, Casanada F, Miller YI, Shaw W, Witztum J, Fayad ZA, Tsimikas S. In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes. J Am Coll Cardiol. 2012 Feb 07; 59(6):616-26. PMID: 22300697; PMCID: PMC3333483.
    87. Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum J, Tsimikas S, Miller YI. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J Clin Invest. 2011 Dec; 121(12):4861-9. PMID: 22105168; PMCID: PMC3225997.
    88. Binder CJ, Witztum J. Is atherosclerosis an allergic disease? Circ Res. 2011 Oct 28; 109(10):1103-4. PMID: 22034478.
      View in: PubMed
    89. Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum J, Tsimikas S, Bender TP, McNamara CA. B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012 Jan 06; 110(1):e1-12. PMID: 22034493; PMCID: PMC3253259.
    90. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum J. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. PMID: 21982317; PMCID: PMC3230644.
    91. Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum J, Binder CJ. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011 Oct 05; 478(7367):76-81. PMID: 21979047; PMCID: PMC4826616.
    92. Taleb A, Witztum J, Tsimikas S. Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events. Biomark Med. 2011 Oct; 5(5):673-94. PMID: 22003918; PMCID: PMC3230643.
    93. Ravandi A, Boekholdt SM, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Miller ER, Benessiano J, Tedgui A, Witztum J, Khaw KT, Tsimikas S. Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study. J Lipid Res. 2011 Oct; 52(10):1829-36. PMID: 21821825; PMCID: PMC3173004.
    94. McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum J, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis. 2011 Sep; 70(9):1619-24. PMID: 21670088; PMCID: PMC3147230.
    95. Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum J, Lassmann H. Oxidative damage in multiple sclerosis lesions. Brain. 2011 Jul; 134(Pt 7):1914-24. PMID: 21653539; PMCID: PMC3122372.
    96. von Vietinghoff S, Koltsova EK, Mestas J, Diehl CJ, Witztum J, Ley K. Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation. J Am Coll Cardiol. 2011 May 24; 57(21):2194-204. PMID: 21596236; PMCID: PMC3378670.
    97. Merki E, Graham M, Taleb A, Leibundgut G, Yang X, Miller ER, Fu W, Mullick AE, Lee R, Willeit P, Crooke RM, Witztum J, Tsimikas S. Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. J Am Coll Cardiol. 2011 Apr 12; 57(15):1611-21. PMID: 21474042.
      View in: PubMed
    98. Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass CK, Evans RM, Witztum J. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol. 2011 Mar; 25(3):529-45. PMID: 21273443; PMCID: PMC3045740.
    99. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum J. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. PMID: 21252151; PMCID: PMC3075542.
    100. Steinberg D, Witztum J. Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2311-6. PMID: 21084697.
      View in: PubMed
    101. Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum J, Esko JD, Moulton KS. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919. PMID: 21085708; PMCID: PMC2978080.
    102. Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum J, Tsimikas S, Golenbock D, Moore KJ, Tabas I. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010 Nov 03; 12(5):467-82. PMID: 21035758; PMCID: PMC2991104.
    103. Mendez-Fernandez YV, Stevenson BG, Diehl CJ, Braun NA, Wade NS, Covarrubias R, van Leuven S, Witztum J, Major AS. The inhibitory Fc?RIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) mice. Atherosclerosis. 2011 Jan; 214(1):73-80. PMID: 21084088; PMCID: PMC3052995.
    104. Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum J, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan; 25(1):290-300. PMID: 20876212; PMCID: PMC3005429.
    105. Tsimikas S, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Sandhu MS, Miller ER, Benessiano J, Tedgui A, Witztum J, Khaw KT, Boekholdt SM. Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. J Am Coll Cardiol. 2010 Sep 14; 56(12):946-55. PMID: 20828647.
      View in: PubMed
    106. Faghihnia N, Tsimikas S, Miller ER, Witztum J, Krauss RM. Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. J Lipid Res. 2010 Nov; 51(11):3324-30. PMID: 20713651; PMCID: PMC2952573.
    107. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum J, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. PMID: 20710028; PMCID: PMC2952235.
    108. Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum J, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20. PMID: 20697023; PMCID: PMC2927799.
    109. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum J, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. PMID: 20489162; PMCID: PMC2904601.
    110. Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum J, Tabas I, Tall AR. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010 Jun 25; 106(12):1861-9. PMID: 20431058; PMCID: PMC2995809.
    111. Cardilo-Reis L, Witztum J, Binder CJ. When monocytes come (too) close to our hearts. J Am Coll Cardiol. 2010 Apr 13; 55(15):1639-41. PMID: 20378084.
      View in: PubMed
    112. Shao B, Pennathur S, Pagani I, Oda MN, Witztum J, Oram JF, Heinecke JW. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem. 2010 Jun 11; 285(24):18473-84. PMID: 20378541; PMCID: PMC2881773.
    113. Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum J, Morganelli PM. Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovasc Res. 2010 Jan 01; 85(1):224-31. PMID: 19720605; PMCID: PMC2791057.
    114. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum J, Varki NM, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. PMID: 19828701; PMCID: PMC2792214.
    115. Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum J, Puri KD, Gold MR. Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol. 2009 Nov 01; 183(9):5673-84. PMID: 19843950.
      View in: PubMed
    116. Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum J, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 2010 Apr; 209(2):498-503. PMID: 19880117.
      View in: PubMed
    117. Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum J, Esko JD. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest. 2009 Nov; 119(11):3236-45. PMID: 19805913.
      View in: PubMed
    118. Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum J, Kolls JK. Critical role of IL-17RA in immunopathology of influenza infection. J Immunol. 2009 Oct 15; 183(8):5301-10. PMID: 19783685; PMCID: PMC3638739.
    119. Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum J, Tsimikas S. Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol. 2009 Jun 09; 53(23):2186-96. PMID: 19497447.
      View in: PubMed
    120. Steinberg D, Witztum J. Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9546-7. PMID: 19506257; PMCID: PMC2701045.
    121. Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum J, Bae YS, Miller YI. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res. 2009 Jun 19; 104(12):1355-63. PMID: 19461045; PMCID: PMC2741301.
    122. Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum J, Chapman MJ, Lesnik P. Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis. Circulation. 2009 May 05; 119(17):2367-75. PMID: 19380622.
      View in: PubMed
    123. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum J, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. PMID: 19363291; PMCID: PMC2673862.
    124. Dennis EA, Witztum J. Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1. PMID: 19346336; PMCID: PMC2674715.
    125. Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum J. Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation. 2009 Apr 07; 119(13):1711-9. PMID: 19307470; PMCID: PMC2782388.
    126. Gautier EL, Huby T, Witztum J, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P. Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation. 2009 Apr 07; 119(13):1795-804. PMID: 19307478.
      View in: PubMed
    127. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum J, Klemke RL, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. PMID: 19265037; PMCID: PMC2834250.
    128. Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum J. The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr; 50 Suppl:S388-93. PMID: 19106070; PMCID: PMC2674727.
    129. Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum J, Miller YI. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009 Jan 30; 104(2):210-8, 21p following 218. PMID: 19096031; PMCID: PMC2720065.
    130. Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum J, Wiedermann CJ, Xu Q, Kiechl S. Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study. Eur Heart J. 2009 Jan; 30(1):107-15. PMID: 19019993.
      View in: PubMed
    131. Attie AD, Witztum J, Edwards PA, Lusis JA. In memoriam: Roger A. Davis (1945-2008). J Lipid Res. 2008 Nov; 49(11):2279-80. PMID: 19123270.
      View in: PubMed
    132. Steinberg D, Glass CK, Witztum J. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 2008 Aug 05; 118(6):672-7. PMID: 18678783.
      View in: PubMed
    133. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum J, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. PMID: 18636118; PMCID: PMC2467381.
    134. Tsimikas S, Witztum J. The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Curr Opin Lipidol. 2008 Aug; 19(4):369-77. PMID: 18607184.
      View in: PubMed
    135. Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum J, Tsimikas S. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12; 118(7):743-53. PMID: 18663084.
      View in: PubMed
    136. Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum J, Tsimikas S. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res. 2008 Oct; 49(10):2230-9. PMID: 18594118.
      View in: PubMed
    137. Choi SH, Chae A, Miller E, Messig M, Ntanios F, DeMaria AN, Nissen SE, Witztum J, Tsimikas S. Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study. J Am Coll Cardiol. 2008 Jul 01; 52(1):24-32. PMID: 18582631.
      View in: PubMed
    138. Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum J, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15. PMID: 18541740; PMCID: PMC4492476.
    139. Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum J, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol. 2008 Apr 29; 51(17):1653-62. PMID: 18436117.
      View in: PubMed
    140. Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum J. Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2008 Apr 15; 51(15):1512-24. PMID: 18402913.
      View in: PubMed
    141. Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum J. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 2008 Apr; 31(4):811-22. PMID: 18375431.
      View in: PubMed
    142. Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum J. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar; 9(3):190-5. PMID: 18336236.
      View in: PubMed
    143. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum J, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. PMID: 18263582; PMCID: PMC2447632.
    144. Binder CJ, Hartvigsen K, Witztum J. Promise of immune modulation to inhibit atherogenesis. J Am Coll Cardiol. 2007 Aug 07; 50(6):547-50. PMID: 17678739.
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    145. Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum J, Tsimikas S. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1788-95. PMID: 17541022.
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    146. Bro S, Binder CJ, Witztum J, Olgaard K, Nielsen LB. Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1080-6. PMID: 17347482.
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    147. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum J, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
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    148. Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum J, Lusis AJ, Tsao BP. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res. 2007 Apr; 48(4):794-805. PMID: 17259598.
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    149. Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum J, Li AC. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):878-85. PMID: 17255537.
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    150. MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum J, Esko JD. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest. 2007 Jan; 117(1):153-64. PMID: 17200715; PMCID: PMC1716206.
    151. Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum J, McConnell JP, Kornman KS, Berger PB. Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J Lipid Res. 2007 Feb; 48(2):425-33. PMID: 17093289.
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    152. Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum J. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81. PMID: 17082490.
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    153. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum J, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 07; 114(19):2047-55. PMID: 17060381.
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    154. Tuominen A, Miller YI, Hansen LF, Kesäniemi YA, Witztum J, Hörkkö S. A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2096-102. PMID: 16794225.
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    155. Zipes DP, Zvaifler NJ, Glassock RJ, Gilman S, Muñoz A, Gogolak V, Gordis L, Dedon PC, Guengerich FP, Wasserman SI, Witztum J, Wogan GN. Rosuvastatin: an independent analysis of risks and benefits. MedGenMed. 2006 Jun 14; 8(2):73. PMID: 16926812; PMCID: PMC1785157.
    156. Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum J, Xu Q. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. J Am Coll Cardiol. 2006 Jun 20; 47(12):2436-43. PMID: 16781371.
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    157. Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum J. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol. 2006 Jun 06; 47(11):2219-28. PMID: 16750687.
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    158. Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum J, Kastelein JJ, Tsimikas S. Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J Am Coll Cardiol. 2006 May 02; 47(9):1803-10. PMID: 16682304.
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    159. Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum J, Miller YI. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1169-76. PMID: 16484596.
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    160. Wilson PW, Ben-Yehuda O, McNamara J, Massaro J, Witztum J, Reaven PD. Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study. Atherosclerosis. 2006 Dec; 189(2):364-8. PMID: 16476434.
      View in: PubMed
    161. Segev A, Strauss BH, Witztum J, Lau HK, Tsimikas S. Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina. Am Heart J. 2005 Nov; 150(5):1007-14. PMID: 16290986.
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    162. Witztum J. You are right too! J Clin Invest. 2005 Aug; 115(8):2072-5. PMID: 16075051; PMCID: PMC1180570.
    163. Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS, Witztum J, Berger PB. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med. 2005 Jul 07; 353(1):46-57. PMID: 16000355.
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    164. Arakawa H, Qian JY, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum J, Ueno H. Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits. Circulation. 2005 Jun 21; 111(24):3302-9. PMID: 15956136.
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    165. Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum J. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. PMID: 15897601.
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    166. Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum J. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1213-9. PMID: 15718493.
      View in: PubMed
    167. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum J, Dennis EA. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. PMID: 15722563.
      View in: PubMed
    168. Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum J, Quehenberger O. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76. PMID: 15722561.
      View in: PubMed
    169. Buono C, Binder CJ, Stavrakis G, Witztum J, Glimcher LH, Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1596-601. PMID: 15665085; PMCID: PMC547865.
    170. Schneider M, Witztum J, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 2005 Apr; 46(4):769-78. PMID: 15654123.
      View in: PubMed
    171. Frostegård J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Hörkkö S, Witztum J. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum. 2005 Jan; 52(1):192-200. PMID: 15641060.
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    172. Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum J. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 06; 200(11):1359-70. PMID: 15583011; PMCID: PMC2211955.
    173. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum J, Palinski W, Glass CK. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest. 2004 Dec; 114(11):1564-76. PMID: 15578089; PMCID: PMC529277.
    174. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum J, Palinski W, Tsimikas S. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12. PMID: 15528482.
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    175. Schneider M, Vergès B, Klein A, Miller ER, Deckert V, Desrumaux C, Masson D, Gambert P, Brun JM, Fruchart-Najib J, Blache D, Witztum J, Lagrost L. Alterations in plasma vitamin E distribution in type 2 diabetic patients with elevated plasma phospholipid transfer protein activity. Diabetes. 2004 Oct; 53(10):2633-9. PMID: 15448094.
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    176. Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum J, Nadler JL, Funk CD, Ley K. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Oct 05; 110(14):2024-31. PMID: 15451785.
      View in: PubMed
    177. Tsimikas S, Witztum J, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG. High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation. 2004 Sep 14; 110(11):1406-12. PMID: 15353498.
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    178. Choudhury RP, Rong JX, Trogan E, Elmalem VI, Dansky HM, Breslow JL, Witztum J, Fallon JT, Fisher EA. High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1904-9. PMID: 15319266.
      View in: PubMed
    179. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum J. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004 Aug 03; 110(5):637-41. PMID: 15289389.
      View in: PubMed
    180. Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum J. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest. 2004 Aug; 114(3):427-37. PMID: 15286809; PMCID: PMC484976.
    181. Soep JB, Mietus-Snyder M, Malloy MJ, Witztum J, von Scheven E. Assessment of atherosclerotic risk factors and endothelial function in children and young adults with pediatric-onset systemic lupus erythematosus. Arthritis Rheum. 2004 Jun 15; 51(3):451-7. PMID: 15188333.
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    182. Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum J, Strauss BH. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 2004 Jun 29; 109(25):3164-70. PMID: 15184281.
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    183. Reardon CA, Miller ER, Blachowicz L, Lukens J, Binder CJ, Witztum J, Getz GS. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. J Lipid Res. 2004 Jul; 45(7):1347-54. PMID: 15102879.
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    184. Kinlay S, Behrendt D, Fang JC, Delagrange D, Morrow J, Witztum J, Rifai N, Selwyn AP, Creager MA, Ganz P. Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function. J Am Coll Cardiol. 2004 Feb 18; 43(4):629-34. PMID: 14975474.
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    185. Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Pierce JP, Chang RJ, Witztum J. Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. J Nutr. 2004 Feb; 134(2):342-7. PMID: 14747670.
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    186. Silaste ML, Rantala M, Alfthan G, Aro A, Witztum J, Kesäniemi YA, Hörkkö S. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004 Mar; 24(3):498-503. PMID: 14739118.
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    187. Frostegård J, Wu R, Lemne C, Thulin T, Witztum J, de Faire U. Circulating oxidized low-density lipoprotein is increased in hypertension. Clin Sci (Lond). 2003 Nov; 105(5):615-20. PMID: 12837127.
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    188. Edelstein C, Pfaffinger D, Hinman J, Miller E, Lipkind G, Tsimikas S, Bergmark C, Getz GS, Witztum J, Scanu AM. Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). J Biol Chem. 2003 Dec 26; 278(52):52841-7. PMID: 14557258.
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    189. Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum J. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. PMID: 14501582.
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    190. Russell AP, Gastaldi G, Bobbioni-Harsch E, Arboit P, Gobelet C, Dériaz O, Golay A, Witztum J, Giacobino JP. Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? FEBS Lett. 2003 Sep 11; 551(1-3):104-6. PMID: 12965212.
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    191. Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, Paul SM, Stuehlinger M, Lin KY, Cooke JP, Morrow JD, Ridker PM, Rifai N, Miller E, Witztum J, Mietus-Snyder M. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 2003 Sep 02; 108(9):1059-63. PMID: 12912807.
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    192. Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum J. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003 Oct; 14(10):4196-206. PMID: 14517329; PMCID: PMC207011.
    193. Shaw PX, Goodyear CS, Chang MK, Witztum J, Silverman GJ. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7. PMID: 12794145.
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    194. Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum J, Silverman GJ. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43. PMID: 12740573.
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    195. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum J, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906. PMID: 12639996; PMCID: PMC153760.
    196. Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum J. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol. 2003 Feb 05; 41(3):360-70. PMID: 12575961.
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    197. Tsimikas S, Witztum J. Shifting the diagnosis and treatment of atherosclerosis to children and young adults: a new paradigm for the 21st century. J Am Coll Cardiol. 2002 Dec 18; 40(12):2122-4. PMID: 12505223.
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    198. Fang JC, Kinlay S, Behrendt D, Hikita H, Witztum J, Selwyn AP, Ganz P. Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation. Arterioscler Thromb Vasc Biol. 2002 Dec 01; 22(12):2044-8. PMID: 12482832.
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    199. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum J. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003 Jan 17; 278(3):1561-8. PMID: 12424240.
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    200. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum J. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. PMID: 12411948.
      View in: PubMed
    201. Chang MK, Binder CJ, Torzewski M, Witztum J. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13043-8. PMID: 12244213; PMCID: PMC130583.
    202. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum J, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6. PMID: 12221058.
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    203. Bannykh SI, Witztum J, Bergmark C. Mechanical aortic injury in apoE-deficient mice as a model for development of atherosclerosis: demonstration of leukocyte rolling early after injury. Ultrastruct Pathol. 2002 Jul-Aug; 26(4):251-60. PMID: 12227951.
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    204. Buono C, Come CE, Witztum J, Maguire GF, Connelly PW, Carroll M, Lichtman AH. Influence of C3 deficiency on atherosclerosis. Circulation. 2002 Jun 25; 105(25):3025-31. PMID: 12081998.
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    205. Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum J, Lagrost L. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002 Aug 30; 277(35):31850-6. PMID: 12105225.
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    206. Steinberg D, Witztum J. Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation. 2002 Apr 30; 105(17):2107-11. PMID: 11980692.
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    207. Witztum J. Splenic immunity and atherosclerosis: a glimpse into a novel paradigm? J Clin Invest. 2002 Mar; 109(6):721-4. PMID: 11901180; PMCID: PMC150921.
    208. Huber J, Vales A, Mitulovic G, Blumer M, Schmid R, Witztum J, Binder BR, Leitinger N. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):101-7. PMID: 11788468.
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    209. Subbanagounder G, Wong JW, Lee H, Faull KF, Miller E, Witztum J, Berliner JA. Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. J Biol Chem. 2002 Mar 01; 277(9):7271-81. PMID: 11751881.
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    210. Friedman P, Horkko S, Steinberg D, Witztum J, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 01; 277(9):7010-20. PMID: 11744722.
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    211. Witztum J, Steinberg D. The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc Med. 2001 Apr-May; 11(3-4):93-102. PMID: 11686009.
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