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Joseph Witztum

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Pivotal Role of Oxidation-specific Epitopes in CVD and NASH
    NIH R01HL148188Jul 7, 2019 - Jun 30, 2020
    Role: Principal Investigator
    Role of Immune Mechanisms in Athersclerosis and Inflammation
    NIH P01HL088093Apr 1, 2007 - Apr 30, 2020
    Role: Principal Investigator
    Development of a Vaccine Approach to Inhibit Atherosclerosis
    NIH R01HL086559Feb 10, 2007 - Jan 31, 2013
    Role: Principal Investigator
    LIPID MAPS
    NIH U54GM069338Aug 12, 2003 - Jul 31, 2014
    Role: Co-Investigator
    Role of B-1 Lymphocytes in Athergenesis
    NIH R01HL069464Sep 30, 2001 - Jul 31, 2005
    Role: Principal Investigator
    Discovery and Development of Therapeutic Genes for CHF
    NIH P01HL066941Sep 29, 2000 - Jun 30, 2018
    Role: Co-Investigator
    B-LYMPHOCYTE MEDIATED IMMUNE MECHANISMS IN ATHEROGENESIS
    NIH R01HL064833Jun 1, 2000 - Oct 1, 2001
    Role: Principal Investigator
    SCOR in Molecular Medicine and Atherosclerosis
    NIH P50HL056989Apr 1, 1998 - Mar 31, 2008
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050May 15, 1997 - Dec 11, 1993
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    Anticardiolipin Antibodies and Oxidized Phospholipids
    NIH R01HL057505Jan 1, 1997 - Dec 31, 2000
    Role: Principal Investigator
    APOLIPOPROTEIN E DEFICIENCY AND ATHEROSCLEROSIS
    NIH R01HL039608Apr 1, 1990 - Sep 29, 1991
    Role: Principal Investigator
    Experimental Endocrinology and Metabolism
    NIH T32DK007044Sep 15, 1978 - Nov 30, 2009
    Role: Principal Investigator
    SCOR IN ARTERIOSCLEROSIS
    NIH P50HL014197Dec 1, 1976 - Apr 30, 1997
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel method for quantification of lipoprotein(a)-cholesterol: Implications for improving accuracy of LDL-C measurements. J Lipid Res. 2021 Feb 23; 100053. Yeang C, Witztum JL, Tsimikas S. PMID: 33636163.
      View in: PubMed   Mentions:    Fields:    
    2. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia. Eur Heart J. 2020 Oct 21; 41(40):3936-3945. Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, Hurh E, Kingsbury J, Bartlett VJ, Figueroa AL, Piscitelli P, Singleton W, Witztum JL, Geary RS, Tsimikas S, O'Dea LSL. PMID: 32860031.
      View in: PubMed   Mentions: 1     Fields:    
    3. A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice. J Bone Miner Res. 2021 Jan; 36(1):170-185. Palmieri M, Kim HN, Gomez-Acevedo H, Que X, Tsimikas S, Jilka RL, Manolagas SC, Witztum JL, Ambrogini E. PMID: 32990984.
      View in: PubMed   Mentions:    Fields:    
    4. Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a). J Lipid Res. 2020 Sep; 61(9):1263-1270. Gonen A, Yang X, Yeang C, Alekseeva E, Koschinsky M, Witztum JL, Boffa M, Tsimikas S. PMID: 32641432.
      View in: PubMed   Mentions:    Fields:    
    5. CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in Ldlr-/- Mice. Antibodies (Basel). 2020 Jul 03; 9(3). Biswas TK, VanderLaan PA, Que X, Gonen A, Krishack P, Binder CJ, Witztum JL, Getz GS, Reardon CA. PMID: 32635160.
      View in: PubMed   Mentions:
    6. Statin therapy increases lipoprotein(a) levels. Eur Heart J. 2020 Jun 21; 41(24):2275-2284. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31111151.
      View in: PubMed   Mentions: 18     Fields:    
    7. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. 2020 Jun 16; 52(6):1057-1074.e7. Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK. PMID: 32362324.
      View in: PubMed   Mentions: 7     Fields:    
    8. Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circ Res. 2020 May 08; 126(10):1346-1359. Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J. PMID: 32160811.
      View in: PubMed   Mentions: 4     Fields:    
    9. ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis. Heart. 2020 May; 106(10):738-745. Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S. PMID: 32054669.
      View in: PubMed   Mentions: 2     Fields:    
    10. Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia. Nucleic Acid Ther. 2020 04; 30(2):94-103. Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG. PMID: 32043907.
      View in: PubMed   Mentions: 1     Fields:    
    11. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Statins and increases in Lp(a): an inconvenient truth that needs attention. Eur Heart J. 2020 01 01; 41(1):192-193. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31893480.
      View in: PubMed   Mentions: 3     Fields:    
    13. Lipoprotein(a) Reduction in Persons with Cardiovascular Disease. N Engl J Med. 2020 01 16; 382(3):244-255. Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, Tardif JC, Baum SJ, Steinhagen-Thiessen E, Shapiro MD, Stroes ES, Moriarty PM, Nordestgaard BG, Xia S, Guerriero J, Viney NJ, O'Dea L, Witztum JL. PMID: 31893580.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    14. Volanesorsen, Familial Chylomicronemia Syndrome, and Thrombocytopenia. Reply. N Engl J Med. 2019 12 26; 381(26):2584. Witztum JL, Geary RS, O'Dea L. PMID: 31881148.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 01 07; 31(1):189-206.e8. Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566.
      View in: PubMed   Mentions: 8     Fields:    
    16. Erratum: A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 Nov; 60(11):1979. Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. PMID: 31676683.
      View in: PubMed   Mentions:    Fields:    
    17. Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles. J Endocr Soc. 2019 Dec 01; 3(12):2397-2410. O'Dea LSL, MacDougall J, Alexander VJ, Digenio A, Hubbard B, Arca M, Moriarty PM, Kastelein JJP, Bruckert E, Soran H, Witztum JL, Hegele RA, Gaudet D. PMID: 31777768.
      View in: PubMed   Mentions:
    18. Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. Circ Res. 2019 10 25; 125(10):e55-e70. Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen A, McSkimming C, Marshall MA, Garmey JC, Taylor AM, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA. PMID: 31549940.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis. J Lipid Res. 2019 12; 60(12):2082-2089. Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas S. PMID: 31551368.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    20. N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels. Eur Heart J. 2019 09 01; 40(33):2785-2796. Alexander VJ, Xia S, Hurh E, Hughes SG, O'Dea L, Geary RS, Witztum JL, Tsimikas S. PMID: 31329855.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    21. Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome. N Engl J Med. 2019 08 08; 381(6):531-542. Witztum JL, Gaudet D, Freedman SD, Alexander VJ, Digenio A, Williams KR, Yang Q, Hughes SG, Geary RS, Arca M, Stroes ESG, Bergeron J, Soran H, Civeira F, Hemphill L, Tsimikas S, Blom DJ, O'Dea L, Bruckert E. PMID: 31390500.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    22. ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. J Lipid Res. 2019 08; 60(8):1379-1395. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. PMID: 31092690.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    23. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019 05 07; 73(17):2150-2162. Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR. PMID: 31047003.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    24. Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children. J Am Heart Assoc. 2019 04 16; 8(8):e011199. Posod A, Pechlaner R, Yin X, Burnap SA, Kiechl SJ, Willeit J, Witztum JL, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. PMID: 30968745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography. CJC Open. 2019 May; 1(3):131-140. Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ. PMID: 32159096.
      View in: PubMed   Mentions:
    26. RNA-Targeted Therapeutics. Cell Metab. 2019 Feb 05; 29(2):501. Crooke ST, Witztum JL, Bennett CF, Baker BF. PMID: 30726759.
      View in: PubMed   Mentions: 4     Fields:    
    27. Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 01 01; 115(1):179-189. Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. PMID: 29850765.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 02; 60(2):436-445. Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. PMID: 30563909.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Mol Metab. 2019 02; 20:89-101. Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS. PMID: 30553772.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
      View in: PubMed   Mentions: 2     Fields:    
    31. Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study. J Clin Lipidol. 2018 Nov - Dec; 12(6):1493-1501.e11. van Capelleveen JC, Lee SR, Verbeek R, Kastelein JJP, Wareham NJ, Stroes ESG, Hovingh GK, Khaw KT, Boekholdt SM, Witztum JL, Tsimikas S. PMID: 30249512.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size. J Clin Lipidol. 2018 Sep - Oct; 12(5):1313-1323. Tsimikas S, Fazio S, Viney NJ, Xia S, Witztum JL, Marcovina SM. PMID: 30100157.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Oxidation-specific epitopes restrain bone formation. Nat Commun. 2018 06 06; 9(1):2193. Ambrogini E, Que X, Wang S, Yamaguchi F, Weinstein RS, Tsimikas S, Manolagas SC, Witztum JL, Jilka RL. PMID: 29875355.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    35. Characterizing familial chylomicronemia syndrome: Baseline data of the APPROACH study. J Clin Lipidol. 2018 Sep - Oct; 12(5):1234-1243.e5. Blom DJ, O'Dea L, Digenio A, Alexander VJ, Karwatowska-Prokopczuk E, Williams KR, Hemphill L, Muñiz-Grijalvo O, Santos RD, Baum S, Witztum JL. PMID: 30318066.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    36. The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study. J Clin Lipidol. 2018 Jul - Aug; 12(4):898-907.e2. Davidson M, Stevenson M, Hsieh A, Ahmad Z, Roeters van Lennep J, Crowson C, Witztum JL. PMID: 29784572.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    37. Clinical and biochemical features of different molecular etiologies of familial chylomicronemia. J Clin Lipidol. 2018 Jul - Aug; 12(4):920-927.e4. Hegele RA, Berberich AJ, Ban MR, Wang J, Digenio A, Alexander VJ, D'Erasmo L, Arca M, Jones A, Bruckert E, Stroes ES, Bergeron J, Civeira F, Witztum JL, Gaudet D. PMID: 29748148.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    38. RNA-Targeted Therapeutics. Cell Metab. 2018 04 03; 27(4):714-739. PMID: 29617640.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    39. Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide. J Clin Lipidol. 2018 May - Jun; 12(3):702-710. Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S. PMID: 29574075.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    40. Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 03 01; 200(5):1702-1717. PMID: 29378911.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol. 2018 01 23; 71(3):321-335. PMID: 29348025.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    42. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018 01 16; 71(2):177-192. Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, Liu L. PMID: 29325642.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    43. Interleukin-1 genotypes modulate the long-term effect of lipoprotein(a) on cardiovascular events: The Ioannina Study. J Clin Lipidol. 2018 Mar - Apr; 12(2):338-347. Naka KK, Bechlioullis A, Marini A, Sionis D, Vakalis K, Triantis G, Wilkins L, Rogus J, Kornman KS, Witztum JL, Doucette-Stamm L, Michalis LK, Tsimikas S. PMID: 29310992.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 Dec; 10(6). PMID: 29237681.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    45. Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials. J Clin Lipidol. 2018 Jan - Feb; 12(1):122-129.e2. Marcovina SM, Viney NJ, Hughes SG, Xia S, Witztum JL, Tsimikas S. PMID: 29174389.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    46. Adenoviral intramyocardial VEGF-D?N?C gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up. Eur Heart J. 2017 Sep 01; 38(33):2547-2555. Hartikainen J, Hassinen I, Hedman A, Kivelä A, Saraste A, Knuuti J, Husso M, Mussalo H, Hedman M, Rissanen TT, Toivanen P, Heikura T, Witztum JL, Tsimikas S, Ylä-Herttuala S. PMID: 28903476.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCellsCTClinical Trials
    47. Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017 Jun; 2(3):229-240. Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S. PMID: 29147686.
      View in: PubMed   Mentions:
    48. Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1570-1578. PMID: 28572160.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    49. Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides. N Engl J Med. 2017 07 20; 377(3):222-232. PMID: 28538111.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCTClinical Trials
    50. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2017 06; 37(6):1206-1212. PMID: 28473441.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arterioscler Thromb Vasc Biol. 2017 06; 37(6):1213-1221. PMID: 28473443.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    52. Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2017 07; 5(7):524-533. PMID: 28408323.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    53. The burden of familial chylomicronemia syndrome: interim results from the IN-FOCUS study. Expert Rev Cardiovasc Ther. 2017 May; 15(5):415-423. PMID: 28338353.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    54. Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial. Atherosclerosis. 2017 05; 260:1-7. PMID: 28319871.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    55. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 Feb 21; 69(7):789-800. PMID: 28209220.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    56. The Effects of 2'-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials. Nucleic Acid Ther. 2017 Jun; 27(3):121-129. PMID: 28145801.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    57. Oxidized Phospholipids on Apolipoprotein B-100 and Recurrent Ischemic Events Following Stroke or Transient Ischemic Attack. J Am Coll Cardiol. 2017 Jan 17; 69(2):147-158. PMID: 28081824.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    58. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. PMID: 28002731.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    59. LPA Gene, Ethnicity, and Cardiovascular Events. Circulation. 2017 Jan 17; 135(3):251-263. PMID: 27831500.
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    153. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem. 2010 Jun 11; 285(24):18473-84. Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. PMID: 20378541.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    154. Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovasc Res. 2010 Jan 01; 85(1):224-31. Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum JL, Morganelli PM. PMID: 19720605.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    155. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. PMID: 19828701.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    156. Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol. 2009 Nov 01; 183(9):5673-84. Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum JL, Puri KD, Gold MR. PMID: 19843950.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    157. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 2010 Apr; 209(2):498-503. Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. PMID: 19880117.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    158. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest. 2009 Nov; 119(11):3236-45. Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum JL, Esko JD. PMID: 19805913.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    159. Critical role of IL-17RA in immunopathology of influenza infection. J Immunol. 2009 Oct 15; 183(8):5301-10. Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum JL, Kolls JK. PMID: 19783685.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    160. Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol. 2009 Jun 09; 53(23):2186-96. Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S. PMID: 19497447.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    161. Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9546-7. Steinberg D, Witztum JL. PMID: 19506257.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    162. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res. 2009 Jun 19; 104(12):1355-63. Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller YI. PMID: 19461045.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    163. Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis. Circulation. 2009 May 05; 119(17):2367-75. Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum JL, Chapman MJ, Lesnik P. PMID: 19380622.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    164. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. PMID: 19363291.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    165. Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1. Dennis EA, Witztum JL. PMID: 19346336.
      View in: PubMed   Mentions: 1     Fields:    
    166. Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation. 2009 Apr 07; 119(13):1711-9. Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum JL. PMID: 19307470.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    167. Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation. 2009 Apr 07; 119(13):1795-804. Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P. PMID: 19307478.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    168. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. PMID: 19265037.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    169. The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr; 50 Suppl:S388-93. Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 19106070.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    170. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009 Jan 30; 104(2):210-8, 21p following 218. Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. PMID: 19096031.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    171. Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study. Eur Heart J. 2009 Jan; 30(1):107-15. Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum JL, Wiedermann CJ, Xu Q, Kiechl S. PMID: 19019993.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    172. In memoriam: Roger A. Davis (1945-2008). J Lipid Res. 2008 Nov; 49(11):2279-80. Attie AD, Witztum JL, Edwards PA, Lusis JA. PMID: 19123270.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    173. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 2008 Aug 05; 118(6):672-7. Steinberg D, Glass CK, Witztum JL. PMID: 18678783.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    174. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    175. The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Curr Opin Lipidol. 2008 Aug; 19(4):369-77. Tsimikas S, Witztum JL. PMID: 18607184.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    176. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12; 118(7):743-53. Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S. PMID: 18663084.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    177. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res. 2008 Oct; 49(10):2230-9. Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S. PMID: 18594118.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    178. Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study. J Am Coll Cardiol. 2008 Jul 01; 52(1):24-32. Choi SH, Chae A, Miller E, Messig M, Ntanios F, DeMaria AN, Nissen SE, Witztum JL, Tsimikas S. PMID: 18582631.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    179. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15. Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. PMID: 18541740.
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    180. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol. 2008 Apr 29; 51(17):1653-62. Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. PMID: 18436117.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    181. Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2008 Apr 15; 51(15):1512-24. Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL. PMID: 18402913.
      View in: PubMed   Mentions: 133     Fields:    Translation:Humans
    182. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 2008 Apr; 31(4):811-22. Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL. PMID: 18375431.
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    183. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar; 9(3):190-5. Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. PMID: 18336236.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    184. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. PMID: 18263582.
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    185. Promise of immune modulation to inhibit atherogenesis. J Am Coll Cardiol. 2007 Aug 07; 50(6):547-50. Binder CJ, Hartvigsen K, Witztum JL. PMID: 17678739.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsPHPublic Health
    186. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1788-95. Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S. PMID: 17541022.
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    187. Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1080-6. Bro S, Binder CJ, Witztum JL, Olgaard K, Nielsen LB. PMID: 17347482.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    188. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. PMID: 17211240.
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    189. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res. 2007 Apr; 48(4):794-805. Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis AJ, Tsao BP. PMID: 17259598.
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    190. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):878-85. Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum JL, Li AC. PMID: 17255537.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    191. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest. 2007 Jan; 117(1):153-64. MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum JL, Esko JD. PMID: 17200715.
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    192. Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J Lipid Res. 2007 Feb; 48(2):425-33. Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum JL, McConnell JP, Kornman KS, Berger PB. PMID: 17093289.
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    193. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81. Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. PMID: 17082490.
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    194. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 07; 114(19):2047-55. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. PMID: 17060381.
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    195. A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2096-102. Tuominen A, Miller YI, Hansen LF, Kesäniemi YA, Witztum JL, Hörkkö S. PMID: 16794225.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    196. Rosuvastatin: an independent analysis of risks and benefits. MedGenMed. 2006 Jun 14; 8(2):73. Zipes DP, Zvaifler NJ, Glassock RJ, Gilman S, Muñoz A, Gogolak V, Gordis L, Dedon PC, Guengerich FP, Wasserman SI, Witztum JL, Wogan GN. PMID: 16926812.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    197. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. J Am Coll Cardiol. 2006 Jun 20; 47(12):2436-43. Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q. PMID: 16781371.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    198. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol. 2006 Jun 06; 47(11):2219-28. Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL. PMID: 16750687.
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    199. Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J Am Coll Cardiol. 2006 May 02; 47(9):1803-10. Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJ, Tsimikas S. PMID: 16682304.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    200. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1169-76. Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, Miller YI. PMID: 16484596.
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    201. Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study. Atherosclerosis. 2006 Dec; 189(2):364-8. Wilson PW, Ben-Yehuda O, McNamara J, Massaro J, Witztum J, Reaven PD. PMID: 16476434.
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    202. Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina. Am Heart J. 2005 Nov; 150(5):1007-14. Segev A, Strauss BH, Witztum JL, Lau HK, Tsimikas S. PMID: 16290986.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    203. You are right too! J Clin Invest. 2005 Aug; 115(8):2072-5. Witztum JL. PMID: 16075051.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    204. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med. 2005 Jul 07; 353(1):46-57. Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS, Witztum JL, Berger PB. PMID: 16000355.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    205. Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits. Circulation. 2005 Jun 21; 111(24):3302-9. Arakawa H, Qian JY, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum JL, Ueno H. PMID: 15956136.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    206. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. PMID: 15897601.
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    207. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1213-9. Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. PMID: 15718493.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    208. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. PMID: 15722563.
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    209. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76. Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. PMID: 15722561.
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    210. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1596-601. Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH. PMID: 15665085.
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    211. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 2005 Apr; 46(4):769-78. Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. PMID: 15654123.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    212. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum. 2005 Jan; 52(1):192-200. Frostegård J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Hörkkö S, Witztum JL. PMID: 15641060.
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    213. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 06; 200(11):1359-70. Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. PMID: 15583011.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    214. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest. 2004 Dec; 114(11):1564-76. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK. PMID: 15578089.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    215. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. PMID: 15528482.
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    216. Alterations in plasma vitamin E distribution in type 2 diabetic patients with elevated plasma phospholipid transfer protein activity. Diabetes. 2004 Oct; 53(10):2633-9. Schneider M, Vergès B, Klein A, Miller ER, Deckert V, Desrumaux C, Masson D, Gambert P, Brun JM, Fruchart-Najib J, Blache D, Witztum JL, Lagrost L. PMID: 15448094.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    217. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Oct 05; 110(14):2024-31. Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum JL, Nadler JL, Funk CD, Ley K. PMID: 15451785.
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    218. High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation. 2004 Sep 14; 110(11):1406-12. Tsimikas S, Witztum JL, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG. PMID: 15353498.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCellsCTClinical Trials
    219. High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1904-9. Choudhury RP, Rong JX, Trogan E, Elmalem VI, Dansky HM, Breslow JL, Witztum JL, Fallon JT, Fisher EA. PMID: 15319266.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    220. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004 Aug 03; 110(5):637-41. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. PMID: 15289389.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansPHPublic Health
    221. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest. 2004 Aug; 114(3):427-37. Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. PMID: 15286809.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    222. Assessment of atherosclerotic risk factors and endothelial function in children and young adults with pediatric-onset systemic lupus erythematosus. Arthritis Rheum. 2004 Jun 15; 51(3):451-7. Soep JB, Mietus-Snyder M, Malloy MJ, Witztum JL, von Scheven E. PMID: 15188333.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    223. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 2004 Jun 29; 109(25):3164-70. Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum JL, Strauss BH. PMID: 15184281.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    224. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. J Lipid Res. 2004 Jul; 45(7):1347-54. Reardon CA, Miller ER, Blachowicz L, Lukens J, Binder CJ, Witztum JL, Getz GS. PMID: 15102879.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    225. Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function. J Am Coll Cardiol. 2004 Feb 18; 43(4):629-34. Kinlay S, Behrendt D, Fang JC, Delagrange D, Morrow J, Witztum JL, Rifai N, Selwyn AP, Creager MA, Ganz P. PMID: 14975474.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    226. Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. J Nutr. 2004 Feb; 134(2):342-7. Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Pierce JP, Chang RJ, Witztum JL. PMID: 14747670.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    227. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004 Mar; 24(3):498-503. Silaste ML, Rantala M, Alfthan G, Aro A, Witztum JL, Kesäniemi YA, Hörkkö S. PMID: 14739118.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    228. Circulating oxidized low-density lipoprotein is increased in hypertension. Clin Sci (Lond). 2003 Nov; 105(5):615-20. Frostegård J, Wu R, Lemne C, Thulin T, Witztum JL, de Faire U. PMID: 12837127.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    229. Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). J Biol Chem. 2003 Dec 26; 278(52):52841-7. Edelstein C, Pfaffinger D, Hinman J, Miller E, Lipkind G, Tsimikas S, Bergmark C, Getz GS, Witztum JL, Scanu AM. PMID: 14557258.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    230. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. PMID: 14501582.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    231. Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? FEBS Lett. 2003 Sep 11; 551(1-3):104-6. Russell AP, Gastaldi G, Bobbioni-Harsch E, Arboit P, Gobelet C, Dériaz O, Golay A, Witztum JL, Giacobino JP. PMID: 12965212.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    232. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 2003 Sep 02; 108(9):1059-63. Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, Paul SM, Stuehlinger M, Lin KY, Cooke JP, Morrow JD, Ridker PM, Rifai N, Miller E, Witztum JL, Mietus-Snyder M. PMID: 12912807.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    233. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003 Oct; 14(10):4196-206. Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum JL. PMID: 14517329.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    234. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7. Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. PMID: 12794145.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    235. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43. Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ. PMID: 12740573.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    236. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. PMID: 12639996.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    237. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol. 2003 Feb 05; 41(3):360-70. Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum JL. PMID: 12575961.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    238. Shifting the diagnosis and treatment of atherosclerosis to children and young adults: a new paradigm for the 21st century. J Am Coll Cardiol. 2002 Dec 18; 40(12):2122-4. Tsimikas S, Witztum JL. PMID: 12505223.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    239. Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation. Arterioscler Thromb Vasc Biol. 2002 Dec 01; 22(12):2044-8. Fang JC, Kinlay S, Behrendt D, Hikita H, Witztum JL, Selwyn AP, Ganz P. PMID: 12482832.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    240. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003 Jan 17; 278(3):1561-8. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. PMID: 12424240.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    241. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. PMID: 12411948.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    242. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13043-8. Chang MK, Binder CJ, Torzewski M, Witztum JL. PMID: 12244213.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    243. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. PMID: 12221058.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    244. Mechanical aortic injury in apoE-deficient mice as a model for development of atherosclerosis: demonstration of leukocyte rolling early after injury. Ultrastruct Pathol. 2002 Jul-Aug; 26(4):251-60. Bannykh SI, Witztum JL, Bergmark C. PMID: 12227951.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    245. Influence of C3 deficiency on atherosclerosis. Circulation. 2002 Jun 25; 105(25):3025-31. Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH. PMID: 12081998.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    246. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002 Aug 30; 277(35):31850-6. Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum JL, Lagrost L. PMID: 12105225.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    247. Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation. 2002 Apr 30; 105(17):2107-11. Steinberg D, Witztum JL. PMID: 11980692.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    248. Splenic immunity and atherosclerosis: a glimpse into a novel paradigm? J Clin Invest. 2002 Mar; 109(6):721-4. Witztum JL. PMID: 11901180.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    249. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):101-7. Huber J, Vales A, Mitulovic G, Blumer M, Schmid R, Witztum JL, Binder BR, Leitinger N. PMID: 11788468.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    250. Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. J Biol Chem. 2002 Mar 01; 277(9):7271-81. Subbanagounder G, Wong JW, Lee H, Faull KF, Miller E, Witztum JL, Berliner JA. PMID: 11751881.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    251. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 01; 277(9):7010-20. Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. PMID: 11744722.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    252. The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc Med. 2001 Apr-May; 11(3-4):93-102. Witztum JL, Steinberg D. PMID: 11686009.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
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