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Bing Ren

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0653
La Jolla CA 92093
Phone8/8-22--5766
Emailbiren@ucsd.edu
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    Collapse Overview 
    Collapse Overview
    Our laboratory is interested in understanding how the complex gene regulatory networks in mammalian cells control cellular proliferation and differentiation. The research is divided into two general areas: 1) the development of genomics and bioinformatics tools that allow genome wide identification of regulatory targets for transcription factors; and, 2) the application of these tools to the study of transcription factors that play critical roles in cancer.

    Research Focus Areas:

  • Genetics and Genomics

  • Gene Expression and Regulation

  • Signal Transduction


    • Collapse Research 
    Collapse Research Activities and Funding
    Epigenomic analysis of neural circuits in Alzheimer's disease mouse models
    NIH/NIA R01AG067153Apr 15, 2020 - Mar 31, 2025
    Role: Co-Principal Investigator
    Epigenome-based Cell Census and Regulatory Element Discovery in the Aging Mouse Brain
    NIH/NIA R01AG066018Sep 30, 2019 - Jun 30, 2024
    Role: Co-Principal Investigator
    High throughput CRISPR-mediated functional validation of regulatory elements
    NIH/NHGRI UM1HG009402Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    San Diego Center for 4D Nucleome Research
    NIH/NIDDK U54DK107977Sep 30, 2015 - Jul 31, 2020
    Role: Principal Investigator
    The Organizational Hub and Web Portal for the 4D Nucleome Network
    NIH/NCI U01CA200147Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Non-coding Variants Predisposing to Age-related Macular Degeneration
    NIH/NHGRI R01HG008135Aug 24, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Functional Analysis of T2D Associated Non-coding SNPs
    NIH/NIDDK U01DK105541May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Integrative Analysis of Haplotype-Resolved Human Epigenome Maps
    NIH/NIEHS R01ES024984Sep 8, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Center for Mammalian Regulatory Genomics
    NIH/NHGRI U54HG006997Sep 21, 2012 - Jul 31, 2017
    Role: Principal Investigator
    The San Diego Epigenome Center
    NIH/NIEHS U01ES017166Sep 29, 2008 - Jun 30, 2014
    Role: Principal Investigator
    Genome-wide map of active promoters in the mouse cells
    NIH/NHGRI R01HG003991Sep 18, 2008 - Jul 31, 2012
    Role: Principal Investigator
    TRANSCRIPTION FACTOR TARGET MAPPING IN MAMMALIAN GENOME
    NIH/NCI R33CA105829Aug 16, 2004 - Oct 31, 2008
    Role: Principal Investigator
    TRANSCRIPTION FACTOR TARGET MAPPING IN MAMMALIAN GENOME
    NIH/NCI R21CA105829Aug 16, 2004 - Jul 31, 2005
    Role: Principal Investigator
    Mapping transcriptional regulatory elements in human DNA
    NIH/NHGRI U01HG003151Sep 30, 2003 - Sep 30, 2008
    Role: Principal Investigator
    Graduate Training Program in Bioinformatics
    NIH/NIGMS T32GM008806Jul 1, 2001 - Jun 30, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 11; 575(7784):699-703. Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. PMID: 31748743.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    2. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    3. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019 06; 21(6):743-754. Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR, Ren B, Cleveland DW. PMID: 31160708.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 05; 569(7757):570-575. Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. PMID: 31019297.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Nat Struct Mol Biol. 2019 03; 26(3):164-174. Patel L, Kang R, Rosenberg SC, Qiu Y, Raviram R, Chee S, Hu R, Ren B, Cole F, Corbett KD. PMID: 30778236.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019 01 14; 35(1):81-94.e7. Jiang Q, Isquith J, Zipeto MA, Diep RH, Pham J, Delos Santos N, Reynoso E, Chau J, Leu H, Lazzari E, Melese E, Ma W, Fang R, Minden M, Morris S, Ren B, Pineda G, Holm F, Jamieson C. PMID: 30612940.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. Neuro Oncol. 2018 09 03; 20(10):1310-1320. Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. PMID: 29660021.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell. 2018 06 14; 173(7):1796-1809.e17. Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK. PMID: 29779944.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    10. NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. Genes Dev. 2018 05 01; 32(9-10):682-694. Fei J, Ishii H, Hoeksema MA, Meitinger F, Kassavetis GA, Glass CK, Ren B, Kadonaga JT. PMID: 29759984.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14; 21(7):1870-1882. Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. PMID: 29141219.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure. Circulation. 2017 Oct 24; 136(17):1613-1625. Rosa-Garrido M, Chapski DJ, Schmitt AD, Kimball TH, Karbassi E, Monte E, Balderas E, Pellegrini M, Shih TT, Soehalim E, Liem D, Ping P, Galjart NJ, Ren S, Wang Y, Ren B, Vondriska TM. PMID: 28802249.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. The Three-Dimensional Organization of Mammalian Genomes. Annu Rev Cell Dev Biol. 2017 10 06; 33:265-289. Yu M, Ren B. PMID: 28783961.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    14. Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. Cell Stem Cell. 2017 04 06; 20(4):533-546.e7. DeBoever C, Li H, Jakubosky D, Benaglio P, Reyna J, Olson KM, Huang H, Biggs W, Sandoval E, D'Antonio M, Jepsen K, Matsui H, Arias A, Ren B, Nariai N, Smith EN, D'Antonio-Chronowska A, Farley EK, Frazer KA. PMID: 28388430.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    15. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J Cell Biol. 2017 03 06; 216(3):607-621. Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, Wong AK, Lee AY, Nguyen K, Dekker C, Ren B, Black BE, Cleveland DW. PMID: 28235947.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    17. A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome. Cell Rep. 2016 11 15; 17(8):2042-2059. Schmitt AD, Hu M, Jung I, Xu Z, Qiu Y, Tan CL, Li Y, Lin S, Lin Y, Barr CL, Ren B. PMID: 27851967.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    18. Genome-wide mapping and analysis of chromosome architecture. Nat Rev Mol Cell Biol. 2016 12; 17(12):743-755. Schmitt AD, Hu M, Ren B. PMID: 27580841.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    19. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan KL, Shen Y, Ren B. PMID: 26813977.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    20. Transcriptional Enhancers: Bridging the Genome and Phenome. Cold Spring Harb Symp Quant Biol. 2015; 80:17-26. Ren B, Yue F. PMID: 26582789.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Human body epigenome maps reveal noncanonical DNA methylation variation. Nature. 2015 Jul 09; 523(7559):212-6. Schultz MD, He Y, Whitaker JW, Hariharan M, Mukamel EA, Leung D, Rajagopal N, Nery JR, Urich MA, Chen H, Lin S, Lin Y, Jung I, Schmitt AD, Selvaraj S, Ren B, Sejnowski TJ, Wang W, Ecker JR. PMID: 26030523.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    22. A CRISPR Connection between Chromatin Topology and Genetic Disorders. Cell. 2015 May 21; 161(5):955-957. Ren B, Dixon JR. PMID: 26000472.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    23. Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell. 2015 Apr 02; 16(4):386-99. Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M. PMID: 25842977.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    24. Chromatin architecture reorganization during stem cell differentiation. Nature. 2015 Feb 19; 518(7539):331-6. Dixon JR, Jung I, Selvaraj S, Shen Y, Antosiewicz-Bourget JE, Lee AY, Ye Z, Kim A, Rajagopal N, Xie W, Diao Y, Liang J, Zhao H, Lobanenkov VV, Ecker JR, Thomson JA, Ren B. PMID: 25693564.
      View in: PubMed   Mentions: 309     Fields:    Translation:HumansCells
    25. A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Nov 20; 515(7527):355-64. Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B. PMID: 25409824.
      View in: PubMed   Mentions: 394     Fields:    Translation:HumansAnimalsCells
    26. Distinct and predictive histone lysine acetylation patterns at promoters, enhancers, and gene bodies. G3 (Bethesda). 2014 Aug 12; 4(11):2051-63. Rajagopal N, Ernst J, Ray P, Wu J, Zhang M, Kellis M, Ren B. PMID: 25122670.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell. 2014 Jun 05; 14(6):762-75. Gorkin DU, Leung D, Ren B. PMID: 24905166.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    28. Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6690-5. Leung D, Du T, Wagner U, Xie W, Lee AY, Goyal P, Li Y, Szulwach KE, Jin P, Lorincz MC, Ren B. PMID: 24757056.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    29. Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing. Nat Biotechnol. 2013 Dec; 31(12):1111-8. Selvaraj S, R Dixon J, Bansal V, Ren B. PMID: 24185094.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    30. STAR: an integrated solution to management and visualization of sequencing data. Bioinformatics. 2013 Dec 15; 29(24):3204-10. Wang T, Liu J, Shen L, Tonti-Filippini J, Zhu Y, Jia H, Lister R, Whitaker JW, Ecker JR, Millar AH, Ren B, Wang W. PMID: 24078702.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Mapping human epigenomes. Cell. 2013 Sep 26; 155(1):39-55. Rivera CM, Ren B. PMID: 24074860.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    32. Developmental biology. Enhancing pluripotency and lineage specification. Science. 2013 Jul 19; 341(6143):245-7. Xie W, Ren B. PMID: 23869010.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. RFECS: a random-forest based algorithm for enhancer identification from chromatin state. PLoS Comput Biol. 2013; 9(3):e1002968. Rajagopal N, Xie W, Li Y, Wagner U, Wang W, Stamatoyannopoulos J, Ernst J, Kellis M, Ren B. PMID: 23526891.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    34. Comparative annotation of functional regions in the human genome using epigenomic data. Nucleic Acids Res. 2013 Apr; 41(8):4423-32. Won KJ, Zhang X, Wang T, Ding B, Raha D, Snyder M, Ren B, Wang W. PMID: 23482391.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    35. Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood. 2012 Aug 16; 120(7):1473-84. Lo MC, Peterson LF, Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn EY, Komeno Y, Ly M, Ommen HB, Chen IM, Hokland P, Willman CL, Ren B, Zhang DE. PMID: 22740448.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    36. Enhancers: multi-dimensional signal integrators. Transcription. 2011 Sep-Oct; 2(5):226-30. Jin F, Li Y, Ren B, Natarajan R. PMID: 22231119.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    37. Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res. 2011 Oct; 21(10):1393-409. Hawkins RD, Hon GC, Yang C, Antosiewicz-Bourget JE, Lee LK, Ngo QM, Klugman S, Ching KA, Edsall LE, Ye Z, Kuan S, Yu P, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Ren B. PMID: 21876557.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    38. PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5290-5. Jin F, Li Y, Ren B, Natarajan R. PMID: 21402921.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    39. 9p21 DNA variants associated with coronary artery disease impair interferon-? signalling response. Nature. 2011 Feb 10; 470(7333):264-8. Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu XD, Topol EJ, Rosenfeld MG, Frazer KA. PMID: 21307941.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansCells
    40. Next-generation genomics: an integrative approach. Nat Rev Genet. 2010 Jul; 11(7):476-86. Hawkins RD, Hon GC, Ren B. PMID: 20531367.
      View in: PubMed   Mentions: 230     Fields:    
    41. Genome-wide prediction of transcription factor binding sites using an integrated model. Genome Biol. 2010 Jan 22; 11(1):R7. Won KJ, Ren B, Wang W. PMID: 20096096.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    42. Discovery and annotation of functional chromatin signatures in the human genome. PLoS Comput Biol. 2009 Nov; 5(11):e1000566. Hon G, Wang W, Ren B. PMID: 19918365.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    43. Finding distal regulatory elements in the human genome. Curr Opin Genet Dev. 2009 Dec; 19(6):541-9. Heintzman ND, Ren B. PMID: 19854636.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    44. Predictive chromatin signatures in the mammalian genome. Hum Mol Genet. 2009 Oct 15; 18(R2):R195-201. Hon GC, Hawkins RD, Ren B. PMID: 19808796.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    45. An integrated approach to identifying cis-regulatory modules in the human genome. PLoS One. 2009; 4(5):e5501. Won KJ, Agarwal S, Shen L, Shoemaker R, Ren B, Wang W. PMID: 19434238.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    46. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature. 2009 May 07; 459(7243):108-12. Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B. PMID: 19295514.
      View in: PubMed   Mentions: 1085     Fields:    Translation:HumansCells
    47. Prediction of regulatory elements in mammalian genomes using chromatin signatures. BMC Bioinformatics. 2008 Dec 18; 9:547. Won KJ, Chepelev I, Ren B, Wang W. PMID: 19094206.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    48. ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome. PLoS Comput Biol. 2008 Oct; 4(10):e1000201. Hon G, Ren B, Wang W. PMID: 18927605.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    49. Genome-wide mapping of allele-specific protein-DNA interactions in human cells. Nat Methods. 2008 Apr; 5(4):307-9. Maynard ND, Chen J, Stuart RK, Fan JB, Ren B. PMID: 18345007.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    50. Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res. 2008 Jan; 18(1):46-59. Barrera LO, Li Z, Smith AD, Arden KC, Cavenee WK, Zhang MQ, Green RD, Ren B. PMID: 18042645.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    51. Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell. 2007 Mar 23; 128(6):1231-45. Kim TH, Abdullaev ZK, Smith AD, Ching KA, Loukinov DI, Green RD, Zhang MQ, Lobanenkov VV, Ren B. PMID: 17382889.
      View in: PubMed   Mentions: 503     Fields:    Translation:HumansAnimalsCells
    52. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet. 2007 Mar; 39(3):311-8. Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, Hawkins RD, Barrera LO, Van Calcar S, Qu C, Ching KA, Wang W, Weng Z, Green RD, Crawford GE, Ren B. PMID: 17277777.
      View in: PubMed   Mentions: 1382     Fields:    Translation:HumansCells
    53. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res. 2006 Jun 01; 66(11):5565-73. Toyo-oka K, Bowen TJ, Hirotsune S, Li Z, Jain S, Ota S, Escoubet-Lozach L, Lozach LE, Garcia-Bassets I, Bassett IG, Lozach J, Rosenfeld MG, Glass CK, Eisenman R, Ren B, Hurlin P, Wynshaw-Boris A. PMID: 16740691.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    54. The transcriptional regulatory code of eukaryotic cells--insights from genome-wide analysis of chromatin organization and transcription factor binding. Curr Opin Cell Biol. 2006 Jun; 18(3):291-8. Barrera LO, Ren B. PMID: 16647254.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    55. Genome-wide location analysis: insights on transcriptional regulation. Hum Mol Genet. 2006 Apr 15; 15 Spec No 1:R1-7. Hawkins RD, Ren B. PMID: 16651365.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    56. Genome-wide analysis of protein-DNA interactions. Annu Rev Genomics Hum Genet. 2006; 7:81-102. Kim TH, Ren B. PMID: 16722805.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    57. An all-round view of eukaryotic transcription. Genome Biol. 2006; 7(7):323. Kim TH, Ren B. PMID: 16879733.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    58. A high-resolution map of active promoters in the human genome. Nature. 2005 Aug 11; 436(7052):876-80. Kim TH, Barrera LO, Zheng M, Qu C, Singer MA, Richmond TA, Wu Y, Green RD, Ren B. PMID: 15988478.
      View in: PubMed   Mentions: 456     Fields:    Translation:HumansCells
    59. Direct isolation and identification of promoters in the human genome. Genome Res. 2005 Jun; 15(6):830-9. Kim TH, Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM, Glass CK, Rosenfeld MG, Myers RM, Ren B. PMID: 15899964.
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    60. beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. Oncogene. 2005 Jan 20; 24(4):597-604. Kim TH, Xiong H, Zhang Z, Ren B. PMID: 15558022.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    61. Use of chromatin immunoprecipitation assays in genome-wide location analysis of mammalian transcription factors. Methods Enzymol. 2004; 376:304-15. Ren B, Dynlacht BD. PMID: 14975314.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    62. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8164-9. Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B. PMID: 12808131.
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