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    Aaron Carlin

    TitleAssociate Physician
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0640
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      University of California, San Diego, San DiegoFellowship & Chief Fellowship06/2015Infectious Diseases
      University of California, San Diego, San DiegoResidency06/2011Internal Medicine
      University of California, San Diego, San DiegoMD, PhD06/2009Medicine, Biomedical Sciences
      University of California, Los Angeles, Los AngelesBS/BA06/2000Microbiology & Molecular Genetics, Philosophy
      Collapse Awards and Honors
      University of California, San Diego2008Gold Humanism Honor Society
      Kiwanis Club of San Diego Foundation2008  - 2009Walter A. Zitlau Memorial Award
      University of California, San Diego2008  - 2009Department of Pediatrics Award
      University of California, San Diego2010  - 2011Excellence in Teaching Award
      UCSD2017  - 2018KL2 Career Development Award
      2017  - 2022Burroughs Wellcome Career Award for Medical Scientists

      Collapse Overview 
      Collapse Overview
      Dr. Aaron Carlin received his received his M.D. and Ph.D. at UCSD. After graduation, Dr. Carlin joined the Physician Scientist Training Program at UCSD where he completed a Residency in Internal Medicine and a Fellowship and Chief Fellowship in Infectious Diseases. He subsequently joined the UCSD Department of Medicine, Division of Infectious Diseases. In addition to attending on the Solid Organ Transplant and Hematology/Oncology Infectious Disease services, Dr. Carlin conducts basic and translational research that utilizes cutting edge molecular techniques to understand the mechanisms by which leading pathogens, like Zika virus, Dengue virus and Hepatitis C virus, cause disease in humans. His approach focuses on identifying mechanisms by which anti-viral transcriptional programs are regulated in myeloid cells and how pathogenic viruses subvert host responses to cause human disease. Ultimately, Dr. Carlin aims to exploit this detailed understanding of host-viral interactions to understand how and why certain microorganisms cause human disease, develop new methods for diagnosing infectious disease and identify the best targets for new antimicrobials.

      Collapse Research 
      Collapse Research Activities and Funding
      Deciphering Human Innate Immune Responses to Zika Virus Infection
      Burroughs Wellcome Career Award for Medical ScientistsJan 1, 2018 - Jan 1, 2023
      Role: PI

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Carlin A, Plummer EM, Vizcarra EA, Sheets N, Joo Y, Tang W, Day J, Greenbaum J, Glass CK, Diamond MS, Shresta S. An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses. Cell Rep. 2017 Nov 07; 21(6):1600-1612. PMID: 29117564.
        View in: PubMed
      2. Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin A, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A. Physiological Exploration of the Long-term Evolutionary Selection Against Expression of N-glycolylneuraminic Acid in the Brain. J Biol Chem. 2017 Jan 03. PMID: 28049733.
        View in: PubMed
      3. Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin A, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 2017 Feb 07; 25(2):412-427. PMID: 28041958.
        View in: PubMed
      4. Carlin A, Aristizabal P, Song Q, Wang H, Paulson MS, Stamm LM, Schooley RT, Wyles DL. Temporal dynamics of inflammatory cytokines/chemokines during sofosbuvir and ribavirin therapy for genotype 2 and 3 hepatitis C infection. Hepatology. 2015 Oct; 62(4):1047-58. PMID: 26147061; PMCID: PMC4589477 [Available on 10/01/16].
      5. Ali SR, Fong JJ, Carlin A, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med. 2014 Jun 02; 211(6):1231-42. PMID: 24799499; PMCID: PMC4042635.
      6. Muto J, Morioka Y, Yamasaki K, Kim M, Garcia A, Carlin A, Varki A, Gallo RL. Hyaluronan digestion controls DC migration from the skin. J Clin Invest. 2014 Mar; 124(3):1309-19. PMID: 24487587; PMCID: PMC3934161.
      7. Shibata N, Carlin A, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13; 288(50):35812-23. PMID: 24189069; PMCID: PMC3861632.
      8. Uchiyama S, Carlin A, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J Exp Med. 2009 Aug 31; 206(9):1845-52. PMID: 19687228; PMCID: PMC2737157.
      9. Weiman S, Dahesh S, Carlin A, Varki A, Nizet V, Lewis AL. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 2009 Nov; 19(11):1204-13. PMID: 19643844; PMCID: PMC2757575.
      10. Carlin A, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009 Aug 03; 206(8):1691-9. PMID: 19596804; PMCID: PMC2722167.
      11. Carlin A, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009 Apr 02; 113(14):3333-6. PMID: 19196661; PMCID: PMC2665898.
      12. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin A, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. PMID: 17646166; PMCID: PMC2588433.
      13. Carlin A, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 2007 Feb; 189(4):1231-7. PMID: 16997964; PMCID: PMC1797352.
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