Benjamin Gastfriend

Title(s)Postdoctoral Scholar, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Maryland, College Park, MDBS05/2016
    University of Wisconsin, Madison, WIPhD05/2022

    Collapse Research 
    Collapse Research Activities and Funding
    Development of Tissue-Specific Properties in Central Nervous System Mural Cells
    NIH F32NS134680Mar 1, 2024 - Feb 28, 2026
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pericytes Enrich the Basement Membrane and Reduce Neutrophil Transmigration in an In Vitro Model of Peripheral Inflammation at the Blood-Brain Barrier. Biomater Res. 2024; 28:0081. McCloskey MC, Ahmad SD, Widom LP, Kasap P, Gastfriend BD, Shusta EV, Palecek SP, Engelhardt B, Gaborski TR, Flax J, Waugh RE, McGrath JL. PMID: 39363889; PMCID: PMC11447289.
      View in: PubMed   Mentions:
    2. Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest. Sci Adv. 2024 Feb 02; 10(5):eadi1737. Gastfriend BD, Snyder ME, Holt HE, Daneman R, Palecek SP, Shusta EV. PMID: 38306433; PMCID: PMC10836734.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Dural mural cells paint an anti-inflammatory picture. J Exp Med. 2024 Feb 05; 221(2). Lummis NC, Gastfriend BD, Daneman R. PMID: 38270593; PMCID: PMC10818063.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain. 2022 12 19; 145(12):4334-4348. Nishihara H, Perriot S, Gastfriend BD, Steinfort M, Cibien C, Soldati S, Matsuo K, Guimbal S, Mathias A, Palecek SP, Shusta EV, Pasquier RD, Engelhardt B. PMID: 35085379; PMCID: PMC10200307.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    5. Antibody-Targeted Liposomes for Enhanced Targeting of the Blood-Brain Barrier. Pharm Res. 2022 Jul; 39(7):1523-1534. Ye Z, Gastfriend BD, Umlauf BJ, Lynn DM, Shusta EV. PMID: 35169958; PMCID: PMC9250590.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    6. Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells. Elife. 2021 11 10; 10. Gastfriend BD, Nishihara H, Canfield SG, Foreman KL, Engelhardt B, Palecek SP, Shusta EV. PMID: 34755601; PMCID: PMC8664294.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    7. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology. Nat Med. 2021 09; 27(9):1600-1606. Wang L, Sievert D, Clark AE, Lee S, Federman H, Gastfriend BD, Shusta EV, Palecek SP, Carlin AF, Gleeson JG. PMID: 34244682; PMCID: PMC8601037.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    8. Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions. STAR Protoc. 2021 06 18; 2(2):100563. Nishihara H, Gastfriend BD, Kasap P, Palecek SP, Shusta EV, Engelhardt B. PMID: 34151293; PMCID: PMC8188617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    9. Integrative analysis of the human brain mural cell transcriptome. J Cereb Blood Flow Metab. 2021 11; 41(11):3052-3068. Gastfriend BD, Foreman KL, Katt ME, Palecek SP, Shusta EV. PMID: 34027687; PMCID: PMC8756477.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. Differentiation of Brain Pericyte-Like Cells from Human Pluripotent Stem Cell-Derived Neural Crest. Curr Protoc. 2021 Jan; 1(1):e21. Gastfriend BD, Stebbins MJ, Du F, Shusta EV, Palecek SP. PMID: 33484491; PMCID: PMC7839246.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB J. 2020 12; 34(12):16693-16715. Nishihara H, Gastfriend BD, Soldati S, Perriot S, Mathias A, Sano Y, Shimizu F, Gosselet F, Kanda T, Palecek SP, Du Pasquier R, Shusta EV, Engelhardt B. PMID: 33124083; PMCID: PMC7686106.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    12. Adaptable pulsatile flow generated from stem cell-derived cardiomyocytes using quantitative imaging-based signal transduction. Lab Chip. 2020 10 21; 20(20):3744-3756. Qian T, Gil DA, Contreras Guzman E, Gastfriend BD, Tweed KE, Palecek SP, Skala MC. PMID: 33048070; PMCID: PMC7699819.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Immobilized metal affinity chromatography optimization for poly-histidine tagged proteins. J Chromatogr A. 2020 Oct 11; 1629:461505. Riguero V, Clifford R, Dawley M, Dickson M, Gastfriend B, Thompson C, Wang SC, O'Connor E. PMID: 32861092.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Antibody screening using a human iPSC-based blood-brain barrier model identifies antibodies that accumulate in the CNS. FASEB J. 2020 09; 34(9):12549-12564. Georgieva JV, Goulatis LI, Stutz CC, Canfield SG, Song HW, Gastfriend BD, Shusta EV. PMID: 32960493; PMCID: PMC7513543.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    15. Transcriptomic comparison of human and mouse brain microvessels. Sci Rep. 2020 07 23; 10(1):12358. Song HW, Foreman KL, Gastfriend BD, Kuo JS, Palecek SP, Shusta EV. PMID: 32704093; PMCID: PMC7378255.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    16. Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells. Fluids Barriers CNS. 2019 Aug 22; 16(1):26. Kim BJ, McDonagh MA, Deng L, Gastfriend BD, Schubert-Unkmeir A, Doran KS, Shusta EV. PMID: 31434575; PMCID: PMC6704684.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    17. An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons. Fluids Barriers CNS. 2019 Aug 07; 16(1):25. Canfield SG, Stebbins MJ, Faubion MG, Gastfriend BD, Palecek SP, Shusta EV. PMID: 31387594; PMCID: PMC6685239.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    18. Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties. Sci Adv. 2019 03; 5(3):eaau7375. Stebbins MJ, Gastfriend BD, Canfield SG, Lee MS, Richards D, Faubion MG, Li WJ, Daneman R, Palecek SP, Shusta EV. PMID: 30891496; PMCID: PMC6415958.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    19. Preventing S. aureus biofilm formation on titanium surfaces by the release of antimicrobial β-peptides from polyelectrolyte multilayers. Acta Biomater. 2019 07 15; 93:50-62. Rodríguez López AL, Lee MR, Ortiz BJ, Gastfriend BD, Whitehead R, Lynn DM, Palecek SP. PMID: 30831325; PMCID: PMC6693497.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    20. Modeling the blood-brain barrier: Beyond the endothelial cells. Curr Opin Biomed Eng. 2018 Mar; 5:6-12. Gastfriend BD, Palecek SP, Shusta EV. PMID: 29915815; PMCID: PMC6003712.
      View in: PubMed   Mentions: 57  
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