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    Joshua Fierer

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111-F
    CA La Jolla 92093
    Phone858-552-7446
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      Collapse Research 
      Collapse Research Activities and Funding
      37th Annual Meeting of the Society for Leukocyte Biology
      NIH/NIAID R13AI062127Sep 30, 2004 - Sep 29, 2005
      Role: Principal Investigator
      Innate Immunity to Salmonella Infections
      NIH/NIAID R01AI047884Mar 1, 2001 - Feb 28, 2008
      Role: Principal Investigator
      Research in Infectious Disease
      NIH/NIAID T32AI007036Jul 1, 1976 - Jun 30, 2021
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mehta SR, Johns S, Stark P, Fierer J. Successful treatment of Aureobasidium pullulans central catheter-related fungemia and septic pulmonary emboli. IDCases. 2017; 10:65-67. PMID: 28951848.
        View in: PubMed
      2. Mehta SR, Estrada J, Ybarra J, Fierer J. Comparison of the BD MAX MRSA XT to the Cepheid™ Xpert® MRSA assay for the molecular detection of methicillin-resistant Staphylococcus aureus from nasal swabs. Diagn Microbiol Infect Dis. 2017 Apr; 87(4):308-310. PMID: 28094151.
        View in: PubMed
      3. Carter CC, Fierer J, Chiu WW, Looney DJ, Strain M, Mehta SR. A Novel Shiga Toxin 1a-Converting Bacteriophage of Shigella sonnei With Close Relationship to Shiga Toxin 2-Converting Pages of Escherichia coli. Open Forum Infect Dis. 2016 Apr; 3(2):ofw079. PMID: 27419156; PMCID: PMC4943565.
      4. Fierer J. Vertebral Osteomyelitis Guidelines. Clin Infect Dis. 2016 Apr 01; 62(7):953-4. PMID: 26743096.
        View in: PubMed
      5. Tchesnokova VL, Ottley LL, Sakamoto K, Fierer J, Sokurenko E, Liss MA. Rapid Identification of Rectal Multidrug-resistant Escherichia coli Before Transrectal Prostate Biopsy. Urology. 2015 Dec; 86(6):1200-5. PMID: 26299464; PMCID: PMC4698053 [Available on 12/01/16].
      6. Marchelletta RR, Gareau MG, Okamoto S, Guiney DG, Barrett KE, Fierer J. Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation. J Infect Dis. 2015 Jul 01; 212(1):128-36. PMID: 25538271; PMCID: PMC4542593.
      7. Liss MA, Johnson JR, Porter SB, Johnston B, Clabots C, Gillis K, Nseyo U, Holden M, Sakamoto K, Fierer J. Clinical and microbiological determinants of infection after transrectal prostate biopsy. Clin Infect Dis. 2015 Apr 01; 60(7):979-87. PMID: 25516194.
        View in: PubMed
      8. Liss MA, Taylor SA, Batura D, Steensels D, Chayakulkeeree M, Soenens C, Rao GG, Dash A, Park S, Patel N, Woo J, McDonald M, Nseyo U, Banapour P, Unterberg S, Ahlering TE, Van Poppel H, Sakamoto K, Fierer J, Black PC. Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy. J Urol. 2014 Dec; 192(6):1673-8. PMID: 24928266.
        View in: PubMed
      9. Viriyakosol S, Jimenez Mdel P, Saijo S, Fierer J. Neither dectin-2 nor the mannose receptor is required for resistance to Coccidioides immitis in mice. Infect Immun. 2014 Mar; 82(3):1147-56. PMID: 24379281; PMCID: PMC3957980.
      10. Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney DG, Fierer J, Barrett KE. Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis. Gastroenterology. 2013 Dec; 145(6):1358-1368.e1-4. PMID: 24001788; PMCID: PMC3899031.
      11. Viriyakosol S, Singhania A, Fierer J, Goldberg J, Kirkland TN, Woelk CH. Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature. BMC Microbiol. 2013 May 28; 13:121. PMID: 23714098; PMCID: PMC3693894.
      12. Valle-Garay E, Montes AH, Corte JR, Meana A, Fierer J, Asensi V. tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis. J Infect Dis. 2013 Jul 15; 208(2):218-23. PMID: 23570848.
        View in: PubMed
      13. Fierer J. Dosing rifampin. Clin Infect Dis. 2013 Jul; 57(1):161. PMID: 23537908.
        View in: PubMed
      14. Viriyakosol S, Jimenez Mdel P, Gurney MA, Ashbaugh ME, Fierer J. Dectin-1 is required for resistance to coccidioidomycosis in mice. MBio. 2013 Feb 05; 4(1):e00597-12. PMID: 23386437; PMCID: PMC3562125.
      15. Patras KA, Wang NY, Fletcher EM, Cavaco CK, Jimenez A, Garg M, Fierer J, Sheen TR, Rajagopal L, Doran KS. Group B Streptococcus CovR regulation modulates host immune signalling pathways to promote vaginal colonization. Cell Microbiol. 2013 Jul; 15(7):1154-67. PMID: 23298320; PMCID: PMC3657335.
      16. Fierer DS, Dieterich DT, Fiel MI, Branch AD, Marks KM, Fusco DN, Hsu R, Smith DM, Fierer J. Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection. Clin Infect Dis. 2013 Apr; 56(7):1038-43. PMID: 23264364; PMCID: PMC3588118.
      17. Woelk CH, Zhang JX, Walls L, Viriyakosol S, Singhania A, Kirkland TN, Fierer J. Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection. BMC Microbiol. 2012 Sep 24; 12:218. PMID: 23006927; PMCID: PMC3528620.
      18. Lin JC, Aung G, Thomas A, Jahng M, Johns S, Fierer J. The use of ceftaroline fosamil in methicillin-resistant Staphylococcus aureus endocarditis and deep-seated MRSA infections: a retrospective case series of 10 patients. J Infect Chemother. 2013 Feb; 19(1):42-9. PMID: 22797874.
        View in: PubMed
      19. Fierer J, Okamoto S, Banerjee A, Guiney DG. Diarrhea and colitis in mice require the Salmonella pathogenicity island 2-encoded secretion function but not SifA or Spv effectors. Infect Immun. 2012 Oct; 80(10):3360-70. PMID: 22778101; PMCID: PMC3457546.
      20. Fierer J, Burton DW, Haghighi P, Deftos LJ. Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related peptide is characteristic of granulomatous inflammation. Clin Infect Dis. 2012 Oct; 55(7):e61-6. PMID: 22670039.
        View in: PubMed
      21. Fierer J. Biofilm formation and Klebsiella pneumoniae liver abscess: true, true and unrelated? Virulence. 2012 May 01; 3(3):241-2. PMID: 22561156; PMCID: PMC3442835.
      22. Duplessis CA, Bavaro M, Simons MP, Marguet C, Santomauro M, Auge B, Collard DA, Fierer J, Lesperance J. Rectal cultures before transrectal ultrasound-guided prostate biopsy reduce post-prostatic biopsy infection rates. Urology. 2012 Mar; 79(3):556-61. PMID: 22386395.
        View in: PubMed
      23. Fierer J, Walls L, Chu P. Recurring Klebsiella pneumoniae pyogenic liver abscesses in a resident of San Diego, California, due to a K1 strain carrying the virulence plasmid. J Clin Microbiol. 2011 Dec; 49(12):4371-3. PMID: 21998428; PMCID: PMC3232960.
      24. Bowman BN, McAdam PR, Vivona S, Zhang JX, Luong T, Belew RK, Sahota H, Guiney D, Valafar F, Fierer J, Woelk CH. Improving reverse vaccinology with a machine learning approach. Vaccine. 2011 Oct 19; 29(45):8156-64. PMID: 21864619.
        View in: PubMed
      25. Guiney DG, Fierer J. The Role of the spv Genes in Salmonella Pathogenesis. Front Microbiol. 2011; 2:129. PMID: 21716657; PMCID: PMC3117207.
      26. Margolis DA, Viriyakosol S, Fierer J, Kirkland TN. The role of reactive oxygen intermediates in experimental coccidioidomycois in mice. BMC Microbiol. 2011 Apr 11; 11:71. PMID: 21481258; PMCID: PMC3088889.
      27. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. PMID: 20479237; PMCID: PMC2890829.
      28. Fierer J. Salmonella outcomes. J Infect Dis. 2008 Dec 01; 198(11):1724. PMID: 19000017.
        View in: PubMed
      29. Maves RC, Cachay ER, Young MA, Fierer J. Secondary syphilis with ocular manifestations in older adults. Clin Infect Dis. 2008 Jun 15; 46(12):e142-5. PMID: 18462103.
        View in: PubMed
      30. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol. 2008 Feb; 251(2):78-85. PMID: 18495099; PMCID: PMC4012540.
      31. Woo H, Okamoto S, Guiney D, Gunn JS, Fierer J. A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice. PLoS One. 2008 Feb 13; 3(2):e1603. PMID: 18270590; PMCID: PMC2225501.
      32. Browne SH, Hasegawa P, Okamoto S, Fierer J, Guiney DG. Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice. FEMS Immunol Med Microbiol. 2008 Mar; 52(2):194-201. PMID: 18248436.
        View in: PubMed
      33. Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC. Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One. 2007 Oct 17; 2(10):e1044. PMID: 17940608; PMCID: PMC2001179.
      34. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007 Sep 07; 130(5):918-31. PMID: 17803913; PMCID: PMC2134986.
      35. Makri S, Purdy AE, Bartlett D, Fierer J. Pathogenicity of environmental isolates of V. cholerae in mice. Microbes Infect. 2007 Sep; 9(11):1351-8. PMID: 17890125.
        View in: PubMed
      36. Fierer J. The role of IL-10 in genetic susceptibility to coccidioidomycosis on mice. Ann N Y Acad Sci. 2007 Sep; 1111:236-44. PMID: 17363443.
        View in: PubMed
      37. Cachay E, Mathews WC, Reed SL, Swancutt MA, Fierer J. Gonococcal meningitis diagnosed by DNA amplification: case report and review of the literature. AIDS Patient Care STDS. 2007 Jan; 21(1):4-8. PMID: 17263653.
        View in: PubMed
      38. Fierer J. IL-10 and susceptibility to Coccidioides immitis infection. Trends Microbiol. 2006 Oct; 14(10):426-7. PMID: 16893649.
        View in: PubMed
      39. Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul; 25(1):143-52. PMID: 16860763.
        View in: PubMed
      40. Jimenez Mdel P, Walls L, Fierer J. High levels of interleukin-10 impair resistance to pulmonary coccidioidomycosis in mice in part through control of nitric oxide synthase 2 expression. Infect Immun. 2006 Jun; 74(6):3387-95. PMID: 16714569; PMCID: PMC1479230.
      41. Kim YR, Brinsmade SR, Yang Z, Escalante-Semerena J, Fierer J. Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice. Infect Immun. 2006 Apr; 74(4):2498-502. PMID: 16552088; PMCID: PMC1418904.
      42. Fierer J, Waters C, Walls L. Both CD4+ and CD8+ T cells can mediate vaccine-induced protection against Coccidioides immitis infection in mice. J Infect Dis. 2006 May 01; 193(9):1323-31. PMID: 16586371.
        View in: PubMed
      43. Braff MH, Zaiou M, Fierer J, Nizet V, Gallo RL. Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens. Infect Immun. 2005 Oct; 73(10):6771-81. PMID: 16177355; PMCID: PMC1230954.
      44. Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastian JF, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005 Jul 18; 202(2):209-15. PMID: 16009720; PMCID: PMC2213009.
      45. Viriyakosol S, Fierer J, Brown GD, Kirkland TN. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun. 2005 Mar; 73(3):1553-60. PMID: 15731053; PMCID: PMC1064940.
      46. Asensi V, Valle E, Meana A, Fierer J, Celada A, Alvarez V, Paz J, Coto E, Carton JA, Maradona JA, Dieguez A, Sarasúa J, Ocaña MG, Arribas JM. In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis. Infect Immun. 2004 Jul; 72(7):3823-8. PMID: 15213123; PMCID: PMC427428.
      47. Goicoechea M, Fierer J, Johns S. Treatment of candidal cholangitis with caspofungin therapy in a patient with a liver transplant: documentation of biliary excretion of caspofungin. Clin Infect Dis. 2004 Apr 01; 38(7):1040-1. PMID: 15034841.
        View in: PubMed
      48. Obonyo M, Guiney DG, Fierer J, Cole SP. Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection. Helicobacter. 2003; 8(5):495-502. PMID: 14535996.
        View in: PubMed
      49. Smith D, Metzgar D, Wills C, Fierer J. Fatal Saccharomyces cerevisiae aortic graft infection. J Clin Microbiol. 2002 Jul; 40(7):2691-2. PMID: 12089311; PMCID: PMC120603.
      50. Fierer J, Swancutt MA, Heumann D, Golenbock D. The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J Immunol. 2002 Jun 15; 168(12):6396-403. PMID: 12055258.
        View in: PubMed
      51. Libby SJ, Lesnick M, Hasegawa P, Kurth M, Belcher C, Fierer J, Guiney DG. Characterization of the spv locus in Salmonella enterica serovar Arizona. Infect Immun. 2002 Jun; 70(6):3290-4. PMID: 12011028; PMCID: PMC127997.
      52. Obonyo M, Guiney DG, Harwood J, Fierer J, Cole SP. Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection. Infect Immun. 2002 Jun; 70(6):3295-9. PMID: 12011029; PMCID: PMC127973.
      53. Fierer J, Kirkland T. Questioning CDC's "select agent" criteria. Science. 2002 Jan 04; 295(5552):43. PMID: 11780643.
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      54. Fierer J. Polymorphonuclear leukocytes and innate immunity to Salmonella infections in mice. Microbes Infect. 2001 Nov-Dec; 3(14-15):1233-7. PMID: 11755411.
        View in: PubMed
      55. Fierer J, Guiney DG. Diverse virulence traits underlying different clinical outcomes of Salmonella infection. J Clin Invest. 2001 Apr; 107(7):775-80. PMID: 11285291; PMCID: PMC199580.
      56. Fierer J, Walls L, Kirkland TN. Genetic evidence for the role of the Lv locus in early susceptibility but not IL-10 synthesis in experimental coccidioidomycosis in C57BL mice. J Infect Dis. 2000 Feb; 181(2):681-5. PMID: 10669355.
        View in: PubMed
      57. Fierer J, Walls L, Wright F, Kirkland TN. Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Infect Immun. 1999 Jun; 67(6):2916-9. PMID: 10338499; PMCID: PMC96600.
      58. Fierer J, Walls L, Eckmann L, Yamamoto T, Kirkland TN. Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis. Infect Immun. 1998 Sep; 66(9):4397-402. PMID: 9712793; PMCID: PMC108531.
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