Deborah Spector

Title(s)Recall Faculty, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-7605-6348 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Massachusetts Institute of TechnologyPh.D.Molecular and Cell Biology
    Smith CollegeBABiological Sciences
    Collapse Awards and Honors
    2014Elected Fellow American Academy of Microbiology
    2011Women Who Mean Business Award
    1995Tribute to Women in Industry Award
    1987Visiting Professor, Hubei Medical College
    1985Kaiser Permanente Teaching Award
    1983Kaiser Permanente teaching Award
    1975  - 1978Helen Hay Whitney Foundation Postdoctoral Fellowship
    1971  - 1974NSF Graduate Fellowship
    1971Sigma Xi
    1971Phi Beta Kappa
    1970NSF Undergraduate Research Participant

    Collapse Overview 
    Collapse Overview
    Dr. Deborah Spector is a Professor in the Department of Cellular and Molecular Medicine and the School of Pharmacy and Pharmaceutical Sciences. She received her PhD from Massachusetts Institute of Technology and was a Helen Hay Whitney Foundation Postdoctoral Fellow at University of California San Francisco. Her research focuses on viral pathogenesis and the molecular mechanisms used by viruses such as herpesviruses and zika virus to subvert the cell's signaling and regulatory pathways. Her lab has also developed a novel strategy for vaccines against viruses that persist and establish latency, and has shown their protective efficacy in animal models of cytomegalovirus infection and genital herpes simplex virus infection.

    In addition to her research, Dr. Spector directs the ACTRI Translational Research Alliance. She is responsible for all aspects of the Translational Research Alliance, including fostering collaborations between clinical investigators, basic scientists, engineers, and industry. A major program that she oversees is Galvanizing Engineering in Medicine (GEM), which is an initiative to bring engineers and clinicians together to develop innovative technologies that can be applied to solving challenging problems in medical care.

    Collapse Research 
    Collapse Research Activities and Funding
    Zika Virus Pathogenesis and Selective Autophagy Induction to Inhibit Virus Production
    NIH R21AI129846Sep 4, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Role of CMV in Heart Disease of HIV-Infected Women and Perinatally Infected Youth
    NIH R56HL125028Sep 12, 2014 - Feb 28, 2017
    Role: Principal Investigator
    Biologic Role of Cytomegalovirus in Endothelial Cell Inflammation and Atheroscler
    NIH R56AI105882Sep 1, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Viral Pathogenesis and Atherosclerosis
    NIH R21AI113443Jun 1, 2014 - May 31, 2017
    Role: Principal Investigator
    Disruption of Neural Stem Cell Homeostasis by Cytomegalovirus
    NIH R21NS084037May 15, 2013 - Apr 30, 2015
    Role: Principal Investigator
    CMV 2012 - combined 4th Congenital Cytomegalovirus Conference and 14th Internatio
    NIH R13AI102493Jul 1, 2012 - Jun 30, 2013
    Role: Principal Investigator
    Atherosclerosis: Cytomegalovirus, Shear Stress, and Endothelial Cells
    NIH R21AI094180Jun 1, 2011 - May 31, 2014
    Role: Principal Investigator
    Disabling of the Anaphase Promoting Complex by Human Cytomegalovirus
    NIH R21AI083991Aug 12, 2009 - Jul 31, 2011
    Role: Principal Investigator
    Development of a Novel Vaccine Against Herpes Simplex Type 2
    NIH R21AI073585Sep 30, 2007 - Aug 31, 2010
    Role: Principal Investigator
    Development of a Cytomegalovirus Vaccine
    NIH R01AI051557Dec 1, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Dysregulation of the Cell Cycle by Human Cytomegalovirus
    NIH R01CA073490Dec 20, 1997 - Nov 30, 2008
    Role: Principal Investigator
    NIH R13CA075122Apr 1, 1997 - Mar 31, 1998
    Role: Principal Investigator
    NIH R13AI027197Mar 1, 1989 - Feb 28, 1990
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    NIH R01AI020954Jan 1, 1987 - Dec 31, 1997
    Role: Principal Investigator
    Human Cytomegalovirus Gene Expression
    NIH R01CA034729May 1, 1983 - May 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus. Nat Commun. 2022 09 12; 13(1):5341. Branche E, Wang YT, Viramontes KM, Valls Cuevas JM, Xie J, Ana-Sosa-Batiz F, Shafee N, Duttke SH, McMillan RE, Clark AE, Nguyen MN, Garretson AF, Crames JJ, Spann NJ, Zhu Z, Rich JN, Spector DH, Benner C, Shresta S, Carlin AF. PMID: 36097162; PMCID: PMC9465152.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    2. Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose. J Virol. 2021 03 01; 95(5). Clark AE, Zhu Z, Krach F, Rich JN, Yeo GW, Spector DH. PMID: 33328307; PMCID: PMC8092816.
      View in: PubMed   Mentions: 3     Fields:    
    3. A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2. Vaccine. 2020 01 03; 38(1):79-89. Bernstein DI, Morello CS, Cardin RD, Bravo FJ, Kraynyak KA, Spector DH. PMID: 31611098.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. J Virol. 2018 03 15; 92(6). Clark AE, Sabalza M, Gordts PLSM, Spector DH. PMID: 29237845; PMCID: PMC5827393.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. RNA-binding protein CPEB1 remodels host and viral RNA landscapes. Nat Struct Mol Biol. 2016 12; 23(12):1101-1110. Batra R, Stark TJ, Clark AE, Belzile JP, Wheeler EC, Yee BA, Huang H, Gelboin-Burkhart C, Huelga SC, Aigner S, Roberts BT, Bos TJ, Sathe S, Donohue JP, Rigo F, Ares M, Spector DH, Yeo GW. PMID: 27775709; PMCID: PMC5140759.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    6. Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types. J Virol. 2016 02 01; 90(3):1259-77. Belzile JP, Sabalza M, Craig M, Clark AE, Morello CS, Spector DH. PMID: 26559848; PMCID: PMC4719619.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    7. Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5. J Virol. 2015 07; 89(13):6928-39. Clark AE, Spector DH. PMID: 25903336; PMCID: PMC4468507.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    8. Human cytomegalovirus riding the cell cycle. Med Microbiol Immunol. 2015 Jun; 204(3):409-19. Spector DH. PMID: 25776080.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    9. IUGR and congenital cytomegalovirus infection. J Infect Dis. 2014 May 15; 209(10):1497-9. Spector DH. PMID: 24526739.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA. J Virol. 2014 Apr; 88(8):4021-39. Belzile JP, Stark TJ, Yeo GW, Spector DH. PMID: 24453373; PMCID: PMC3993748.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    11. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13; 288(50):35812-23. Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. PMID: 24189069; PMCID: PMC3861632.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    12. Cytomegaloviruses: From Molecular Pathogenesis to Therapy. Exploitation of Host Cell Cycle Regulatory Pathways by HCMV. 2013. Spector DH.
    13. Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery. J Virol. 2012 Dec; 86(24):13745-55. DuRose JB, Li J, Chien S, Spector DH. PMID: 23055562; PMCID: PMC3503096.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    14. Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge. Vaccine. 2012 Oct 12; 30(46):6541-6550. Morello CS, Kraynyak KA, Levinson MS, Chen Z, Lee KF, Spector DH. PMID: 22947141; PMCID: PMC3754855.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    15. A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization. J Virol. 2012 Oct; 86(20):11066-77. Strang BL, Bender BJ, Sharma M, Pesola JM, Sanders RL, Spector DH, Coen DM. PMID: 22855486; PMCID: PMC3457161.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    16. Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen. Blood. 2012 Mar 08; 119(10):2293-301. Steininger C, Widhopf GF, Ghia EM, Morello CS, Vanura K, Sanders R, Spector D, Guiney D, Jäger U, Kipps TJ. PMID: 22234695; PMCID: PMC3311256.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    17. High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection. J Virol. 2012 Jan; 86(1):226-35. Stark TJ, Arnold JD, Spector DH, Yeo GW. PMID: 22013051; PMCID: PMC3255895.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    18. Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32. J Virol. 2011 Nov; 85(21):11098-110. Burgdorf SW, Clark CL, Burgdorf JR, Spector DH. PMID: 21865379; PMCID: PMC3194931.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease. J Virol. 2011 Apr; 85(7):3461-72. Morello CS, Levinson MS, Kraynyak KA, Spector DH. PMID: 21270160; PMCID: PMC3067869.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol. 2010 Oct; 84(20):10832-43. Tran K, Kamil JP, Coen DM, Spector DH. PMID: 20686030; PMCID: PMC2950577.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    21. Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products. J Virol. 2010 May; 84(10):5158-70. Sanders RL, Spector DH. PMID: 20200242; PMCID: PMC2863830.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription. J Virol. 2010 Mar; 84(6):3079-93. Tran K, Mahr JA, Spector DH. PMID: 20042513; PMCID: PMC2826056.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    23. Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription. J Virol. 2009 Jun; 83(11):5904-17. Kapasi AJ, Clark CL, Tran K, Spector DH. PMID: 19297489; PMCID: PMC2681946.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomes. J Virol. 2008 Nov; 82(22):11383-97. Sanders RL, Del Rosario CJ, White EA, Spector DH. PMID: 18787008; PMCID: PMC2573290.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    25. Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses. J Virol. 2008 Jul; 82(14):7059-77. Sanders RL, Clark CL, Morello CS, Spector DH. PMID: 18463148; PMCID: PMC2446980.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    26. Subversion of cell cycle regulatory pathways. Curr Top Microbiol Immunol. 2008; 325:243-62. Sanchez V, Spector DH. PMID: 18637510.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    27. A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. PLoS Pathog. 2007 Nov; 3(11):e163. Grey F, Meyers H, White EA, Spector DH, Nelson J. PMID: 17983268; PMCID: PMC2048532.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansCells
    28. Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome. J Virol. 2008 Jan; 82(1):394-407. Kapasi AJ, Spector DH. PMID: 17942543; PMCID: PMC2224385.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    29. Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. J Virol. 2008 Jan; 82(1):529-37. Tran K, Mahr JA, Choi J, Teodoro JG, Green MR, Spector DH. PMID: 17942546; PMCID: PMC2224378.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter. J Virol. 2007 Nov; 81(21):11730-6. Sanchez V, Mahr JA, Orazio NI, Spector DH. PMID: 17715235; PMCID: PMC2168781.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge. J Virol. 2007 Jul; 81(14):7766-75. Morello CS, Kelley LA, Munks MW, Hill AB, Spector DH. PMID: 17507492; PMCID: PMC1933361.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    32. The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus. J Virol. 2007 Mar; 81(6):2573-83. White EA, Del Rosario CJ, Sanders RL, Spector DH. PMID: 17202222; PMCID: PMC1865986.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    33. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Betaherpesviruses: Early viral gene expression and function. 2007; 264-294. White EA and Spector DH .
    34. Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription. J Virol. 2006 Oct; 80(20):9951-61. Shlapobersky M, Sanders R, Clark C, Spector DH. PMID: 17005673; PMCID: PMC1617307.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    35. Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles. J Virol. 2006 Jun; 80(12):5886-96. Sanchez V, Spector DH. PMID: 16731927; PMCID: PMC1472584.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    36. Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus. J Immunol. 2006 Mar 15; 176(6):3760-6. Munks MW, Gold MC, Zajac AL, Doom CM, Morello CS, Spector DH, Hill AB. PMID: 16517745.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    37. Cytomegaloviruses: Molecular Biology and Immunology. Exploitation of host cell cycle regulatory pathways by HCMV. 2006; 205-230. Sanchez V and Spector DH.
    38. Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7. J Virol. 2005 Dec; 79(24):15477-93. Tamrakar S, Kapasi AJ, Spector DH. PMID: 16306619; PMCID: PMC1316045.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    39. Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation. J Virol. 2005 Jun; 79(12):7438-52. White EA, Spector DH. PMID: 15919900; PMCID: PMC1143685.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    40. Systemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challenge. J Virol. 2005 Jan; 79(1):159-75. Morello CS, Ye M, Hung S, Kelley LA, Spector DH. PMID: 15596812; PMCID: PMC538742.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization. J Virol. 2004 Oct; 78(20):11233-45. Ye M, Morello CS, Spector DH. PMID: 15452242; PMCID: PMC521820.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    42. Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production. J Virol. 2004 Oct; 78(20):11219-32. Sanchez V, McElroy AK, Yen J, Tamrakar S, Clark CL, Schwartz RA, Spector DH. PMID: 15452241; PMCID: PMC521808.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    43. Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression. J Virol. 2004 Feb; 78(4):1817-30. White EA, Clark CL, Sanchez V, Spector DH. PMID: 14747546; PMCID: PMC369462.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    44. Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus. J Virol. 2003 Dec; 77(24):13214-24. Sanchez V, McElroy AK, Spector DH. PMID: 14645578; PMCID: PMC296097.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    45. Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication. J Virol. 2003 Feb; 77(4):2369-76. Biswas N, Sanchez V, Spector DH. PMID: 12551974; PMCID: PMC141111.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    46. Viral induction of site-specific chromosome damage. Rev Med Virol. 2003 Jan-Feb; 13(1):21-37. Fortunato EA, Spector DH. PMID: 12516060.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    47. Virology. CMV makes a timely exit. Science. 2002 Aug 02; 297(5582):778-9. Sanchez V, Spector DH. PMID: 12161637.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    48. Infection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome. J Virol. 2002 Jun; 76(11):5369-79. Fortunato EA, Sanchez V, Yen JY, Spector DH. PMID: 11991965; PMCID: PMC137046.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    49. Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replication. J Virol. 2002 May; 76(10):4822-35. Morello CS, Ye M, Spector DH. PMID: 11967299; PMCID: PMC136169.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCellsPHPublic Health
    50. Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication. J Virol. 2002 Mar; 76(6):2973-89. Sanchez V, Clark CL, Yen JY, Dwarakanath R, Spector DH. PMID: 11861863; PMCID: PMC135995.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    51. Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challenge. J Virol. 2002 Mar; 76(5):2100-12. Ye M, Morello CS, Spector DH. PMID: 11836387; PMCID: PMC153826.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    52. The use of recombinant baculoviruses for sustained expression of human cytomegalovirus immediate early proteins in fibroblasts. Virology. 2001 Jun 05; 284(2):297-307. Dwarakanath RS, Clark CL, McElroy AK, Spector DH. PMID: 11384228.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    53. Dysregulation of cyclin E gene expression in human cytomegalovirus-infected cells requires viral early gene expression and is associated with changes in the Rb-related protein p130. J Virol. 2000 May; 74(9):4192-206. McElroy AK, Dwarakanath RS, Spector DH. PMID: 10756032; PMCID: PMC111934.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    54. Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65). J Virol. 2000 Apr; 74(8):3696-708. Morello CS, Cranmer LD, Spector DH. PMID: 10729145; PMCID: PMC111879.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCellsPHPublic Health
    55. Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus. Trends Microbiol. 2000 Mar; 8(3):111-9. Fortunato EA, McElroy AK, Sanchez I, Spector DH. PMID: 10707064.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    56. Specific chromosome 1 breaks induced by human cytomegalovirus. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):853-8. Fortunato EA, Dell'Aquila ML, Spector DH. PMID: 10639169; PMCID: PMC15420.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    57. In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83). J Virol. 1999 Sep; 73(9):7678-93. Morello CS, Cranmer LD, Spector DH. PMID: 10438858; PMCID: PMC104295.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    58. Regulation of human cytomegalovirus gene expression. Adv Virus Res. 1999; 54:61-128. Fortunato EA, Spector DH. PMID: 10547675.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    59. Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection. J Virol. 1998 Nov; 72(11):9173-80. Rodems SM, Spector DH. PMID: 9765464; PMCID: PMC110336.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    60. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol. 1998 Jul; 18(7):3796-802. Navarro L, Mowen K, Rodems S, Weaver B, Reich N, Spector D, David M. PMID: 9632763; PMCID: PMC108963.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    61. Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription. J Virol. 1998 May; 72(5):3729-41. Salvant BS, Fortunato EA, Spector DH. PMID: 9557655; PMCID: PMC109595.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    62. Separate DNA elements containing ATF/CREB and IE86 binding sites differentially regulate the human cytomegalovirus UL112-113 promoter at early and late times in the infection. J Virol. 1998 Apr; 72(4):2697-707. Rodems SM, Clark CL, Spector DH. PMID: 9525587; PMCID: PMC109712.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    63. p53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus. J Virol. 1998 Mar; 72(3):2033-9. Fortunato EA, Spector DH. PMID: 9499057; PMCID: PMC109496.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    64. Molecular analysis of the differential restriction of human immunodeficiency virus type 1 replication in neuronal cell lines. J Gen Virol. 1997 Dec; 78 ( Pt 12):3255-64. Hsia K, Spector DH, Spector SA. PMID: 9400976.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    65. Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other. J Virol. 1997 Nov; 71(11):8176-85. Fortunato EA, Sommer MH, Yoder K, Spector DH. PMID: 9343168; PMCID: PMC192274.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    66. A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells. J Virol. 1997 May; 71(5):3693-701. Moreno TN, Fortunato EA, Hsia K, Spector SA, Spector DH. PMID: 9094643; PMCID: PMC191518.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    67. Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins. J Virol. 1996 Nov; 70(11):7929-39. Cranmer LD, Clark CL, Morello CS, Farrell HE, Rawlinson WD, Spector DH. PMID: 8892916; PMCID: PMC190865.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    68. DNA immunization confers protection against murine cytomegalovirus infection. J Virol. 1996 Nov; 70(11):7921-8. González Armas JC, Morello CS, Cranmer LD, Spector DH. PMID: 8892915; PMCID: PMC190864.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    69. CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter. J Virol. 1996 Oct; 70(10):6955-66. Schwartz R, Helmich B, Spector DH. PMID: 8794339; PMCID: PMC190745.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    70. Activation and regulation of human cytomegalovirus early genes. Intervirology. 1996; 39(5-6):361-77. Spector DH. PMID: 9130046.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    71. Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest. J Virol. 1995 Nov; 69(11):6697-704. Jault FM, Jault JM, Ruchti F, Fortunato EA, Clark C, Corbeil J, Richman DD, Spector DH. PMID: 7474079; PMCID: PMC189579.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansCells
    72. The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations. J Virol. 1995 Oct; 69(10):6533-40. Scully AL, Sommer MH, Schwartz R, Spector DH. PMID: 7666555; PMCID: PMC189555.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    73. Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences. J Virol. 1995 Mar; 69(3):1645-51. Koval V, Jault FM, Pal PG, Moreno TN, Aiken C, Trono D, Spector SA, Spector DH. PMID: 7853500; PMCID: PMC188762.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    74. Cloning, characterization, and expression of the murine cytomegalovirus homologue of the human cytomegalovirus 28-kDa matrix phosphoprotein (UL99). Virology. 1994 Dec; 205(2):417-29. Cranmer LD, Clark C, Spector DH. PMID: 7975245.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    75. Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J Virol. 1994 Oct; 68(10):6223-31. Sommer MH, Scully AL, Spector DH. PMID: 8083962; PMCID: PMC237042.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    76. The human cytomegalovirus origin of DNA replication (oriLyt) is the critical cis-acting sequence regulating replication-dependent late induction of the viral 1.2-kilobase RNA promoter. J Virol. 1994 Oct; 68(10):6567-77. Wade EJ, Spector DH. PMID: 8083993; PMCID: PMC237077.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    77. Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter. J Virol. 1994 Sep; 68(9):5613-22. Schwartz R, Sommer MH, Scully A, Spector DH. PMID: 8057441; PMCID: PMC236962.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    78. Human cytomegalovirus-mediated enhancement of human immunodeficiency virus type-1 production in monocyte-derived macrophages. Virology. 1994 Feb 15; 199(1):98-104. Lathey JL, Spector DH, Spector SA. PMID: 8116259.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    79. The effects of cytomegalovirus on human immunodeficiency virus replication in brain-derived cells correlate with permissiveness of the cells for each virus. J Virol. 1994 Feb; 68(2):959-73. Jault FM, Spector SA, Spector DH. PMID: 8289398; PMCID: PMC236534.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    80. Interactions Between Retroviruses and Herpesviruses. Positive and negative effects of human cytomegalovirus on HIV replication. 1994; 65-89. Spector DH, Koval V, Jault FM, Lathey J, Spector SA .
    81. In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins. Mol Cell Biol. 1993 Feb; 13(2):1238-50. Klucher KM, Sommer M, Kadonaga JT, Spector DH. PMID: 8423789; PMCID: PMC359009.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    82. An AP-1 binding site is the predominant cis-acting regulatory element in the 1.2-kilobase early RNA promoter of human cytomegalovirus. J Virol. 1992 Apr; 66(4):2407-17. Wade EJ, Klucher KM, Spector DH. PMID: 1312636; PMCID: PMC289036.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    83. Potential host range expansion of the retroviruses. Dev Biol Stand. 1992; 76:153-64. Spector DH. PMID: 1335930.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    84. Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses. J Virol. 1991 Dec; 65(12):6969-78. Koval V, Clark C, Vaishnav M, Spector SA, Spector DH. PMID: 1658386; PMCID: PMC250810.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    85. Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene. Virology. 1991 Nov; 185(1):169-86. Elliott R, Clark C, Jaquish D, Spector DH. PMID: 1718083.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    86. Human immunodeficiency virus infection of human-PBL-SCID mice. Science. 1991 Feb 15; 251(4995):791-4. Mosier DE, Gulizia RJ, Baird SM, Wilson DB, Spector DH, Spector SA. PMID: 1990441.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    87. Herpesvirus Transcription and Its Regulation. Regulation of human cytomegalovirus early gene expression. 1991; 261-285. Spector DH, Klucher KM, Rabert DK, Wright DA .
    88. The human cytomegalovirus 2.7-kilobase RNA promoter contains a functional binding site for the adenovirus major late transcription factor. J Virol. 1990 Sep; 64(9):4189-98. Klucher KM, Spector DH. PMID: 2166813; PMCID: PMC247883.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    89. Human immunodeficiency virus pseudotypes with expanded cellular and species tropism. J Virol. 1990 May; 64(5):2298-308. Spector DH, Wade E, Wright DA, Koval V, Clark C, Jaquish D, Spector SA. PMID: 1691314; PMCID: PMC249391.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    90. Human cytomegalovirus early gene expression. Curr Top Microbiol Immunol. 1990; 154:21-45. Spector DH, Klucher KM, Rabert DK, Wright DA. PMID: 2161321.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    91. Sequences in the human cytomegalovirus 2.7-kilobase RNA promoter which mediate its regulation as an early gene. J Virol. 1989 Dec; 63(12):5334-43. Klucher KM, Rabert DK, Spector DH. PMID: 2555558; PMCID: PMC251200.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    92. Use of molecular probes to detect human cytomegalovirus and human immunodeficiency virus. Clin Chem. 1989 Aug; 35(8):1581-7. Spector SA, Hsia K, Denaro F, Spector DH. PMID: 2547533.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    93. Enzymatic amplification of human cytomegalovirus sequences by polymerase chain reaction. J Clin Microbiol. 1989 Aug; 27(8):1802-9. Hsia K, Spector DH, Lawrie J, Spector SA. PMID: 2549097; PMCID: PMC267675.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    94. Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit. J Virol. 1989 Jul; 63(7):3117-27. Wright DA, Spector DH. PMID: 2542619; PMCID: PMC250869.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    95. Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency. Curr Top Microbiol Immunol. 1989; 152:195-9. Mosier DE, Gulizia RJ, Baird SM, Spector S, Spector D, Kipps TJ, Fox RI, Carson DA, Cooper N, Richman DD, et al. PMID: 2553338.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    96. DNA Probes for Infectious Diseases. DNA probes for the detection of human cytomegalovirus. 1989; 13:135-140. Spector SA, Dankner WM, Denaro F, Spector DH.
    97. Proceedings of the 7th International Congress of Immunology. Elements of the human immune system: studies of mature lymphoid cells following xenotransplantation to SCID mice. Progress in Immunology. 1989; VII:1264-1271. Mosier DE, Gulizia RJ, Wilson DB, Baird SM, Spector SA, Spector DH, Richman DD, Fox RI, Kipps TJ.
    98. Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene. J Virol. 1988 Sep; 62(9):3463-73. Staprans SI, Rabert DK, Spector DH. PMID: 2841497; PMCID: PMC253471.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    99. Pathogenesis of murine cytomegalovirus infection: identification of infected cells in the spleen during acute and latent infections. J Virol. 1988 Mar; 62(3):987-97. Mercer JA, Wiley CA, Spector DH. PMID: 2828694; PMCID: PMC253658.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    100. Replication of the murine cytomegalovirus genome: structure and role of the termini in the generation and cleavage of concatenates. Virology. 1988 Jan; 162(1):98-107. Marks JR, Spector DH. PMID: 2827390.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    101. Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169. J Virol. 1988 Jan; 62(1):331-40. Wright DA, Staprans SI, Spector DH. PMID: 2824853; PMCID: PMC250534.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    102. Terminal structure and heterogeneity in human cytomegalovirus strain AD169. J Virol. 1986 Sep; 59(3):591-604. Tamashiro JC, Spector DH. PMID: 3016322; PMCID: PMC253215.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    103. Pathogenesis of acute murine cytomegalovirus infection in resistant and susceptible strains of mice. J Virol. 1986 Feb; 57(2):497-504. Mercer JA, Spector DH. PMID: 3003382; PMCID: PMC252762.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    104. 2.2-kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169. J Virol. 1986 Feb; 57(2):591-602. Staprans SI, Spector DH. PMID: 3003391; PMCID: PMC252774.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    105. DNA Probes. Molecular analysis of cytomegalovirus infections. 1986; 177-183. Spector DH, Spector SA.
    106. The use of DNA probes in studies of human cytomegalovirus. Clin Chem. 1985 Sep; 31(9):1514-20. Spector SA, Spector DH. PMID: 2992841.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    107. Cell-related sequences in the DNA genome of human cytomegalovirus strain AD169. J Virol. 1985 Sep; 55(3):843-8. Shaw SB, Rasmussen RD, McDonough SH, Staprans SI, Vacquier JP, Spector DH. PMID: 2991601; PMCID: PMC255072.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    108. Sequences in human cytomegalovirus which hybridize with the avian retrovirus oncogene v-myc are G + C rich and do not hybridize with the human c-myc gene. Mol Cell Biol. 1985 Jun; 5(6):1525-30. Rasmussen RD, Staprans SI, Shaw SB, Spector DH. PMID: 2993868; PMCID: PMC366886.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    109. Analysis of the major transcripts encoded by the long repeat of human cytomegalovirus strain AD169. J Virol. 1985 Mar; 53(3):711-8. McDonough SH, Staprans SI, Spector DH. PMID: 2983083; PMCID: PMC254698.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    110. Genetic Engineering: Principles and Methods,. Molecular studies on the cytomegalovirus of mice and men. 1985; 7:199-234. Spector DH.
    111. Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA. J Virol. 1984 Nov; 52(2):541-8. Tamashiro JC, Filpula D, Friedmann T, Spector DH. PMID: 6092675; PMCID: PMC254556.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    112. Fusion of the termini of the murine cytomegalovirus genome after infection. J Virol. 1984 Oct; 52(1):24-8. Marks JR, Spector DH. PMID: 6090700; PMCID: PMC254484.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    113. Detection of human cytomegalovirus in clinical specimens by DNA-DNA hybridization. J Infect Dis. 1984 Jul; 150(1):121-6. Spector SA, Rua JA, Spector DH, McMillan R. PMID: 6086767.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    114. Acquired Immune Deficiency Syndrome, UCLA Symp. Mol. Cell. Biol., New Series,. Association of human cytomegalovirus with Kaposi's sarcoma. 1984; 6:109-126. Spector DH, Shaw SB, Hock LJ, Abrams D, Mitsuyasu RT, Gottlieb MS .
    115. Herpesvirus, UCLA Symp. Mol. Cell. Biol., New Series. Organization and expression of the repeats at the termini and L-S junction of human cytomegalovirus strain AD169. 1984; 21:441-454. Spector DH, McDonough SH, Staprans SI, Tamashiro JC, Friedmann T, Filpula D .
    116. The oncogenic potential of human cytomegalovirus. Prog Med Virol. 1984; 29:45-89. Spector DH, Spector SA. PMID: 6322235.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    117. Transcription in mouse embryo cells permissively infected by murine cytomegalovirus. Virology. 1983 Nov; 131(1):247-54. Marks JR, Mercer JA, Spector DH. PMID: 6196913.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    118. Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith Strain). Virology. 1983 Aug; 129(1):94-106. Mercer JA, Marks JR, Spector DH. PMID: 6310888.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    119. Human cytomegalovirus (strain AD169) contains sequences related to the avian retrovirus oncogene v-myc. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):3889-93. Spector DH, Vacquier JP. PMID: 6306648; PMCID: PMC394164.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    120. Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169. Virology. 1983 Feb; 125(1):31-46. McDonough SH, Spector DH. PMID: 6187127.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    121. Molecular epidemiology of cytomegalovirus infections in premature twin infants and their mother. Pediatr Infect Dis. 1982 Nov-Dec; 1(6):405-9. Spector SA, Spector DH. PMID: 6298754.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    122. Cleavage maps for human cytomegalovirus DNA strain AD169 for restriction endonucleases EcoRI, BglII, and HindIII. J Virol. 1982 May; 42(2):558-82. Spector DH, Hock L, Tamashiro JC. PMID: 6283173; PMCID: PMC256882.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    123. Construction of a cloned library of the EcoRI fragments from the human cytomegalovirus genome (strain AD169). J Virol. 1982 May; 42(2):547-57. Tamashiro JC, Hock LJ, Spector DH. PMID: 6283172; PMCID: PMC256881.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    124. Gene-specific probes for avian retroviruses. Curr Top Microbiol Immunol. 1981; 91:41-80. Spector DH. PMID: 6273070.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    125. Animal Virus Genetics - ICN-UCLA Symp. on Animal Virus Genetics. Molecular cloning of the human cytomegalovirus genome (strain AD 169). 1980; 21-37. Tamashiro JC, Spector DH .
    126. Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Cell. 1979 Oct; 18(2):347-59. Hughes SH, Payvar F, Spector D, Schimke RT, Robinson HL, Payne GS, Bishop JM, Varmus HE. PMID: 227605.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    127. Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1348-52. Hughes SH, Stubblefield E, Payvar F, Engel JD, Dodgson JB, Spector D, Cordell B, Schimke RT, Varmus HE. PMID: 286316; PMCID: PMC383248.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    128. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell. 1978 Dec; 15(4):1397-410. Hughes SH, Shank PR, Spector DH, Kung HJ, Bishop JM, Varmus HE, Vogt PK, Breitman ML. PMID: 215325.
      View in: PubMed   Mentions: 146     Fields:    Translation:Cells
    129. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc Natl Acad Sci U S A. 1978 Sep; 75(9):4102-6. Spector DH, Varmus HE, Bishop JM. PMID: 212733; PMCID: PMC336059.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    130. Genesis of a virus-transforming gene. Natl Cancer Inst Monogr. 1978 May; (48):219-23. Bishop JM, Baker B, Fujita D, McCombe P, Sheiness D, Smith K, Spector DH, Stehelin D, Varmus HE. PMID: 219354.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    131. Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses. Cell. 1978 Feb; 13(2):371-9. Spector DH, Smith K, Padgett T, McCombe P, Roulland-Dussoix D, Moscovici C, Varmus HE, Bishop JM. PMID: 203404.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    132. Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses. Cell. 1978 Feb; 13(2):381-6. Spector DH, Baker B, Varmus HE, Bishop JM. PMID: 203405.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    133. Post-transcriptional control of avian oncornavirus transforming gene sequences in mammalian cells. Nature. 1977 Sep 08; 269(5624):175-9. Krzyzek RA, Lau AF, Faras AJ, Spector DH. PMID: 198665.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    134. Cold Spring Harbor Conference on Cell Proliferation. The function and origin of the transforming gene of avian sarcoma virus. 1977; 4:1159-1168. Varmus H, Spector D, Stehelin D, Deng C-T, Padgett T, Stubblefield E, Bishop JM.
    135. Oncogenic Viruses and Host Cell Genes. The distribution of sequences related to the transforming gene of avian sarcoma virus in uninfected vertebrate cells. 1977. Spector DH, Varmus, Bishop JM.
    136. International Cell Biology. The function and origin of the transforming gene of avian sarcoma virus. 1977; 553-557. Varmus H, Spector DH, Stehelin D, Deng C-T, Padgett T, Stubblefield E, Bishop JM.
    137. Symposium on the Molecular Biology of the Mammalian Genetic Apparatus. The transforming gene of avian sarcoma virus. 1977; 263-274. Bishop JM, Stehelin D, Tal J, Fujita D, Spector DH, Roulland-Dossoix D, , Padgett T, Varmus HE.
    138. ICN-UCLA Symposia on Molecular and Cellular Biology. Distribution and function of defined regions of avian tumor virus genomes in viruses and uninfected cells. 1976; 4. Varmus H, Stehelin D, Spector DH, Tal J, Fujita D, Padgett T, Roulland-Dossoix D, Kung H-J, Bishop JM.
    139. Poly(A) on mengovirus RNA. J Virol. 1975 Oct; 16(4):1081-4. Spector DH, Baltimore D. PMID: 170414; PMCID: PMC354771.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    140. Polyadenylic acid on poliovirus RNA IV. Poly(U) in replicative intermediate and double-stranded RNA. Virology. 1975 Oct; 67(2):498-505. Spector DH, Baltimore D. PMID: 171838.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    141. Studies on the function of polyadenylic acid on poliovirus RNA. Cell. 1975 Sep; 6(1):41-4. Spector DH, Villa-Komaroff L, Baltimore D. PMID: 170001.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    142. Polyadenylic acid on poliovirus RNA. II. poly(A) on intracellular RNAs. J Virol. 1975 Jun; 15(6):1418-31. Spector DH, Baltimore D. PMID: 167193; PMCID: PMC354609.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    143. Polyadenylic acid on poliovirus RNA. III. In vitro addition of polyadenylic acid to poliovirus RNAs. J Virol. 1975 Jun; 15(6):1432-9. Spector DH, Baltimore D. PMID: 167194; PMCID: PMC354610.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    144. The molecular biology of poliovirus. Sci Am. 1975 May; 232(5):25-31. Spector DH, Baltimore D. PMID: 167433.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    145. Requirement of 3'-terminal poly(adenylic acid) for the infectivity of poliovirus RNA. Proc Natl Acad Sci U S A. 1974 Aug; 71(8):2983-7. Spector DH, Baltimore D. PMID: 4370340; PMCID: PMC388603.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    146. Mechanisms of Virus Disease. Poliovirus defective interfering particles. 1974. Baltimore D. Cole CN, Villa-Komaroff L, Spector DH.
    147. DDE reduces medullary bone formation in birds. Nature. 1971 Feb 19; 229(5286):571. Oestreicher MI, Shuman DH, Wurster CF. PMID: 4925362.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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