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    Natalie Afshari

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentOphthalmology
    Address9500 Gilman Drive #0946
    CA La Jolla 92093
    Phone858-822-1569
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Integrative Genetic Analyses in Fuchs Endothelial Corneal Dystrophy
      NIH/NEI R01EY023196Mar 1, 2013 - Feb 29, 2016
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Benatti CA, Tsao JZ, Afshari N. Descemet membrane detachment during cataract surgery: etiology and management. Curr Opin Ophthalmol. 2017 Jan; 28(1):35-41. PMID: 27764021.
        View in: PubMed
      2. Gali HE, Afshari N. Patient-centered advancements in cataract surgery. Curr Opin Ophthalmol. 2017 Jan; 28(1):1-2. PMID: 27820749.
        View in: PubMed
      3. Lee CM, Afshari N. The global state of cataract blindness. Curr Opin Ophthalmol. 2017 Jan; 28(1):98-103. PMID: 27820750.
        View in: PubMed
      4. Fukuoka H, Afshari N. The impact of age-related cataract on measures of frailty in an aging global population. Curr Opin Ophthalmol. 2017 Jan; 28(1):93-97. PMID: 27820747.
        View in: PubMed
      5. Meekins LC, Rosado-Adames N, Maddala R, Zhao JJ, Rao PV, Afshari N. Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models. Invest Ophthalmol Vis Sci. 2016 Dec 01; 57(15):6731-6738. PMID: 27951595.
        View in: PubMed
      6. Afshari N. October consultation #6. J Cataract Refract Surg. 2016 Oct; 42(10):1539. PMID: 27839617.
        View in: PubMed
      7. Ho JW, Fernandez MM, Rebong RA, Carlson AN, Kim T, Afshari N. Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center. J Ophthalmic Inflamm Infect. 2016 Dec; 6(1):5. PMID: 26897131; PMCID: PMC4761361.
      8. Benatti CA, Afshari N. Postoperative Pain After Laser Refractive Surgery. Int Ophthalmol Clin. 2016; 56(2):83-100. PMID: 26938340.
        View in: PubMed
      9. Fukuoka H, Sutu C, Afshari N. The impact of cataract surgery on cognitive function in an aging population. Curr Opin Ophthalmol. 2016 Jan; 27(1):3-8. PMID: 26569525.
        View in: PubMed
      10. Sutu C, Fukuoka H, Afshari N. Mechanisms and management of dry eye in cataract surgery patients. Curr Opin Ophthalmol. 2016 Jan; 27(1):24-30. PMID: 26569526.
        View in: PubMed
      11. Stone JS, Afshari N. Cataract surgery: a procedure to us, an experience to the patient. Curr Opin Ophthalmol. 2016 Jan; 27(1):1-2. PMID: 26569529.
        View in: PubMed
      12. Li G, Xu F, Zhu J, Krawczyk M, Zhang Y, Yuan J, Patel S, Wang Y, Lin Y, Zhang M, Cai H, Chen D, Zhang M, Cao G, Yeh E, Lin D, Su Q, Li WW, Sen GL, Afshari N, Chen S, Maas RL, Fu XD, Zhang K, Liu Y, Ouyang H. Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease. J Biol Chem. 2015 Aug 14; 290(33):20448-54. PMID: 26045558; PMCID: PMC4536450.
      13. Afshari N. April consultation #6. J Cataract Refract Surg. 2015 Apr; 41(4):898-9; discussion 899. PMID: 25840318.
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      14. Ho JW, Afshari N. The quest to optimizing cataract surgery outcomes. Curr Opin Ophthalmol. 2015 Jan; 26(1):1-2. PMID: 25415301.
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      15. Ho JW, Afshari N. Advances in cataract surgery: preserving the corneal endothelium. Curr Opin Ophthalmol. 2015 Jan; 26(1):22-7. PMID: 25415300.
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      16. Kim K, Alder B, Vora GK, Carlson AN, Afshari N, Kuo AN, Kim T. Textural interface opacity after Descemet-stripping automated endothelial keratoplasty. J Cataract Refract Surg. 2014 Sep; 40(9):1514-20. PMID: 25135544.
        View in: PubMed
      17. Chang ST, Yamagata AS, Afshari N. Pearls for successful cataract surgery with endothelial keratoplasty. Curr Opin Ophthalmol. 2014 Jul; 25(4):335-9. PMID: 24837575.
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      18. Li YJ, Minear MA, Qin X, Rimmler J, Hauser MA, Allingham RR, Igo RP, Lass JH, Iyengar SK, Klintworth GK, Afshari N, Gregory SG. Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2014 Jun 10; 55(7):4577-84. PMID: 24917144; PMCID: PMC4109404.
      19. Yang H, Afshari N. The yellow intraocular lens and the natural ageing lens. Curr Opin Ophthalmol. 2014 Jan; 25(1):40-3. PMID: 24270599.
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      20. Yang H, Afshari N. Cataract surgery: our ongoing voyage to the promised land. Curr Opin Ophthalmol. 2014 Jan; 25(1):1-2. PMID: 24310373.
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      21. Chen H, Hyatt T, Afshari N. Visual and refractive outcomes of laser cataract surgery. Curr Opin Ophthalmol. 2014 Jan; 25(1):49-53. PMID: 24285124; PMCID: PMC4231136.
      22. Minear MA, Li YJ, Rimmler J, Balajonda E, Watson S, Allingham RR, Hauser MA, Klintworth GK, Afshari N, Gregory SG. Genetic screen of African Americans with Fuchs endothelial corneal dystrophy. Mol Vis. 2013; 19:2508-16. PMID: 24348007; PMCID: PMC3859630.
      23. Espandar L, Allingham RR, Afshari N. Stromal duplication of the iris. JAMA Ophthalmol. 2013 Nov; 131(11):1442. PMID: 24232083.
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      24. Daoud YJ, Munro AD, Delmonte DD, Stinnett S, Kim T, Carlson AN, Afshari N. Effect of cornea donor graft thickness on the outcome of Descemet stripping automated endothelial keratoplasty surgery. Am J Ophthalmol. 2013 Nov; 156(5):860-866.e1. PMID: 24011521.
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      25. Soler VJ, Tran-Viet KN, Galiacy SD, Limviphuvadh V, Klemm TP, St Germain E, Fournié PR, Guillaud C, Maurer-Stroh S, Hawthorne F, Suarez C, Kantelip B, Afshari N, Creveaux I, Luo X, Meng W, Calvas P, Cassagne M, Arné JL, Rozen SG, Malecaze F, Young TL. Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis. J Med Genet. 2013 Apr; 50(4):246-54. PMID: 23349227; PMCID: PMC4115150.
      26. Khor WB, Afshari N. The role of presbyopia-correcting intraocular lenses after laser in situ keratomileusis. Curr Opin Ophthalmol. 2013 Jan; 24(1):35-40. PMID: 23197266.
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      27. Khor WB, Afshari N. The more things change, the more they stay the same. Curr Opin Ophthalmol. 2013 Jan; 24(1):1-2. PMID: 23197269.
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      28. Decroos FC, Delmonte DW, Chow JH, Stinnett SS, Kim T, Carlson AN, Afshari N. Increased Rates of Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Graft Failure and Dislocation in Glaucomatous Eyes with Aqueous Shunts. J Ophthalmic Vis Res. 2012 Jul; 7(3):203-13. PMID: 23264862; PMCID: PMC3520588.
      29. Wheeler J, Hauser MA, Afshari N, Allingham RR, Liu Y. The Genetics of Keratoconus: A Review. Reprod Syst Sex Disord. 2012 Jun 03; (Suppl 6). PMID: 23795306.
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      30. Millender TW, Reller LB, Meekins LC, Afshari N. Streptococcal pharyngitis leading to corneal ulceration. Ocul Immunol Inflamm. 2012 Apr; 20(2):143-4. PMID: 22360434.
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      31. Meekins LC, Afshari N. Ever-evolving technological advances in cataract surgery: can perfection be achieved? Curr Opin Ophthalmol. 2012 Jan; 23(1):1-2. PMID: 22134363.
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      32. Rosado-Adames N, Afshari N. The changing fate of the corneal endothelium in cataract surgery. Curr Opin Ophthalmol. 2012 Jan; 23(1):3-6. PMID: 22134364.
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      33. Afshari N, Gorovoy MS, Yoo SH, Kim T, Carlson AN, Rosenwasser GO, Griffin NB, McCuen BW, Toth CA, Price FW, Price M, Fernandez MM. Dislocation of the donor graft to the posterior segment in descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2012 Apr; 153(4):638-42, 642.e1-2. PMID: 22105800.
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      34. Rebong RA, Santaella RM, Goldhagen BE, Majka CP, Perfect JR, Steinbach WJ, Afshari N. Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis. Invest Ophthalmol Vis Sci. 2011 Sep 21; 52(10):7309-15. PMID: 21849421.
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      35. Li YJ, Minear MA, Rimmler J, Zhao B, Balajonda E, Hauser MA, Allingham RR, Eghrari AO, Riazuddin SA, Katsanis N, Gottsch JD, Gregory SG, Klintworth GK, Afshari N. Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy. PLoS One. 2011 Apr 20; 6(4):e18044. PMID: 21533127; PMCID: PMC3080358.
      36. Hwang RY, Gauthier DJ, Wallace D, Afshari N. Refractive changes after descemet stripping endothelial keratoplasty: a simplified mathematical model. Invest Ophthalmol Vis Sci. 2011 Feb 22; 52(2):1043-54. PMID: 21051729.
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      37. Afshari N. Cataract surgery: from couching to femtosecond, look how far we have come! Curr Opin Ophthalmol. 2011 Jan; 22(1):1. PMID: 21900755.
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      38. Fernandez MM, Afshari N. Cataracts: we have perfected the surgery, but is it time for prevention? Curr Opin Ophthalmol. 2011 Jan; 22(1):2-3. PMID: 21150604.
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      39. Gupta PK, Bordelon A, Vroman DT, Afshari N, Kim T. Early outcomes of descemet stripping automated endothelial keratoplasty in pseudophakic eyes with anterior chamber intraocular lenses. Am J Ophthalmol. 2011 Jan; 151(1):24-28.e1. PMID: 20970110.
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      40. Reeves SW, Kang PC, Zlogar DF, Gupta PK, Stinnett S, Afshari N. Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. Ophthalmic Surg Lasers Imaging. 2010 Mar 09; 1-2. PMID: 20337327.
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      41. Santaella R, Afshari N. Presbyopia-correcting intraocular lenses: 'one lens does not fit all'. Curr Opin Ophthalmol. 2010 Jan; 21(1):1-3. PMID: 19910791.
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      42. Patel M, Challa P, Afshari N. Descemet's stripping automated endothelial keratoplasty in a patient with four glaucoma tubes. Ann Ophthalmol (Skokie). 2010; 42 Spec No:20-3. PMID: 21138146.
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      43. Fernandez MM, Afshari N. Endothelial Keratoplasty: From DLEK to DMEK. Middle East Afr J Ophthalmol. 2010 Jan; 17(1):5-8. PMID: 20543930; PMCID: PMC2880365.
      44. Riazuddin SA, Zaghloul NA, Al-Saif A, Davey L, Diplas BH, Meadows DN, Eghrari AO, Minear MA, Li YJ, Klintworth GK, Afshari N, Gregory SG, Gottsch JD, Katsanis N. Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. Am J Hum Genet. 2010 Jan; 86(1):45-53. PMID: 20036349; PMCID: PMC2801746.
      45. Caldwell MC, Afshari N, Decroos FC, Proia AD. The histology of graft adhesion in descemet stripping with endothelial keratoplasty. Am J Ophthalmol. 2009 Aug; 148(2):277-81. PMID: 19464669.
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      46. Hong A, Caldwell MC, Kuo AN, Afshari N. Air bubble-associated endothelial trauma in descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2009 Aug; 148(2):256-9. PMID: 19426961.
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      47. Kempton JE, Shields MB, Afshari N, Dou W, Adelman RA. Fellow selection criteria. Ophthalmology. 2009 May; 116(5):1020-1020.e4. PMID: 19410971.
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      48. Jun B, Kuo AN, Afshari N, Carlson AN, Kim T. Refractive change after descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter. Cornea. 2009 Jan; 28(1):19-23. PMID: 19092399.
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      49. Duarte MC, Herndon LW, Gupta PK, Afshari N. DSEK in eyes with double glaucoma tubes. Ophthalmology. 2008 Aug; 115(8):1435, 1435.e1. PMID: 18675702.
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      50. Fernandez MM, Buckley EG, Afshari N. Descemet stripping automated endothelial keratoplasty in a child. J AAPOS. 2008 Jun; 12(3):314-6. PMID: 18589388.
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      51. Afshari N, Li YJ, Pericak-Vance MA, Gregory S, Klintworth GK. Genome-wide linkage scan in fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1093-7. PMID: 18502986; PMCID: PMC2712757.
      52. Afshari N, Ma JJ, Duncan SM, Pineda R, Starr CE, Decroos FC, Johnson CS, Adelman RA. Trends in resistance to ciprofloxacin, cefazolin, and gentamicin in the treatment of bacterial keratitis. J Ocul Pharmacol Ther. 2008 Apr; 24(2):217-23. PMID: 18331204.
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      53. Afshari N, Bahadur RP, Eifrig DE, Thogersen IB, Enghild JJ, Klintworth GK. Atypical asymmetric lattice corneal dystrophy associated with a novel homozygous mutation (Val624Met) in the TGFBI gene. Mol Vis. 2008 Mar 12; 14:495-9. PMID: 18385782; PMCID: PMC2268855.
      54. DeCroos FC, Afshari N. Perioperative antibiotics and anti-inflammatory agents in cataract surgery. Curr Opin Ophthalmol. 2008 Jan; 19(1):22-6. PMID: 18090893.
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      55. Fernandez MM, Afshari N. Nutrition and the prevention of cataracts. Curr Opin Ophthalmol. 2008 Jan; 19(1):66-70. PMID: 18090901.
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      56. Kuo AN, Harvey TM, Afshari N. Novel delivery method to reduce endothelial injury in descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2008 Jan; 145(1):91-6. PMID: 17996209.
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      57. Johnson CS, Mian SI, Moroi S, Epstein D, Izatt J, Afshari N. Role of corneal elasticity in damping of intraocular pressure. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2540-4. PMID: 17525182.
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      58. Borboli S, Afshari N, Watkins L, Foster CS. Presumed oculoglandular syndrome from Bartonella quintana. Ocul Immunol Inflamm. 2007 Jan-Feb; 15(1):41-3. PMID: 17365807.
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      59. Yeh DL, Stinnett SS, Afshari N. Analysis of bacterial cultures in infectious keratitis, 1997 to 2004. Am J Ophthalmol. 2006 Dec; 142(6):1066-8. PMID: 17157596.
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      60. Wright TM, Afshari N. Microbial keratitis following corneal transplantation. Am J Ophthalmol. 2006 Dec; 142(6):1061-2. PMID: 17157593.
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      61. Schwinn DA, Afshari N. alpha(1)-Adrenergic receptor antagonists and the iris: new mechanistic insights into floppy iris syndrome. Surv Ophthalmol. 2006 Sep-Oct; 51(5):501-12. PMID: 16950249.
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      62. Onyewu C, Afshari N, Heitman J. Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrob Agents Chemother. 2006 Nov; 50(11):3963-5. PMID: 16923949; PMCID: PMC1635197.
      63. Pieramici SF, Afshari N. Genetics of corneal dystrophies: the evolving landscape. Curr Opin Ophthalmol. 2006 Aug; 17(4):361-6. PMID: 16900028.
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      64. Afshari N, Pittard AB, Siddiqui A, Klintworth GK. Clinical study of Fuchs corneal endothelial dystrophy leading to penetrating keratoplasty: a 30-year experience. Arch Ophthalmol. 2006 Jun; 124(6):777-80. PMID: 16769829.
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      65. Afshari N, Duncan SM, Tanhehco TY, Azar DT. Optimal size and location for corneal rotational autografts: a simplified mathematical model. Arch Ophthalmol. 2006 Mar; 124(3):410-3. PMID: 16534062.
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      66. Schwinn DA, Afshari N. Alpha1-adrenergic antagonists and floppy iris syndrome: tip of the iceberg? Ophthalmology. 2005 Dec; 112(12):2059-60. PMID: 16325704.
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      67. Blackmon SM, Fekrat S, Setlik DE, Afshari N. Posterior dislocation of a crystalline lens associated with airbag deployment. J Cataract Refract Surg. 2005 Dec; 31(12):2431-2. PMID: 16473246.
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      68. Afshari N, Schirra F, Rapoza PA, Talamo JH, Ludwig K, Adelman RA, Kenyon KR. Laser in situ keratomileusis outcomes following radial keratotomy, astigmatic keratotomy, photorefractive keratectomy, and penetrating keratoplasty. J Cataract Refract Surg. 2005 Nov; 31(11):2093-100. PMID: 16412921.
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      69. Setlik DE, Seldomridge DL, Adelman RA, Semchyshyn TM, Afshari N. The effectiveness of isobutyl cyanoacrylate tissue adhesive for the treatment of corneal perforations. Am J Ophthalmol. 2005 Nov; 140(5):920-1. PMID: 16310475.
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      70. Kang PC, Klintworth GK, Kim T, Carlson AN, Adelman R, Stinnett S, Afshari N. Trends in the indications for penetrating keratoplasty, 1980-2001. Cornea. 2005 Oct; 24(7):801-3. PMID: 16160495.
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      71. Reeves SW, Stinnett S, Adelman RA, Afshari N. Risk factors for progression to penetrating keratoplasty in patients with keratoconus. Am J Ophthalmol. 2005 Oct; 140(4):607-11. PMID: 16226512.
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      72. Afshari N, Wright TM, Cummings TJ, Proia AD. Collagen-rich crystalloids in a scarred vascularized cornea. Arch Pathol Lab Med. 2005 Sep; 129(9):1179-82. PMID: 16119996.
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      73. Tanhehco TY, Chiavetta SV, Lee PP, Fowler AM, Afshari N. "Cracked-mud" ciprofloxacin precipitates on a corneal graft. Ophthalmic Surg Lasers Imaging. 2005 May-Jun; 36(3):252-3. PMID: 15957485.
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      74. Eifrig DE, Afshari N, Buchanan HW, Bowling BL, Klintworth GK. Polymorphic corneal amyloidosis: a disorder due to a novel mutation in the transforming growth factor beta-induced (BIGH3) gene. Ophthalmology. 2004 Jun; 111(6):1108-14. PMID: 15177960.
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      75. Klintworth GK, Bao W, Afshari N. Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied family. Invest Ophthalmol Vis Sci. 2004 May; 45(5):1382-8. PMID: 15111592.
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      76. Adelman RA, Brauner SC, Afshari N, Grosskreutz CL. Cataract formation after initial trabeculectomy in young patients. Ophthalmology. 2003 Mar; 110(3):625-9. PMID: 12623833.
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      77. Adelman RA, Membreno JH, Afshari N, Stoessel KM. West Nile virus chorioretinitis. Retina. 2003 Feb; 23(1):100-1. PMID: 12652240.
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      78. Moore JE, McMullen TC, Campbell IL, Rohan R, Kaji Y, Afshari N, Usui T, Archer DB, Adamis AP. The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1 RA gene therapy. Invest Ophthalmol Vis Sci. 2002 Sep; 43(9):2905-15. PMID: 12202509.
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      79. Siddiqui N, Afshari N. The changing face of the genetics of corneal dystrophies. Curr Opin Ophthalmol. 2002 Aug; 13(4):199-203. PMID: 12165700.
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      80. Afshari N, Afshari MA, Foster CS. Inflammatory conditions of the eye associated with rheumatic diseases. Curr Rheumatol Rep. 2001 Oct; 3(5):453-8. PMID: 11564378.
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      81. Afshari N, Azar NF, Afshari MA, Azar DT. Corneal transplantation in children. Int Ophthalmol Clin. 2001; 41(4):1-7. PMID: 11698731.
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      82. Afshari MA, Hart L, Afshari N, Mukai S. Ophthalmic ultrasonography in children. Int Ophthalmol Clin. 2001; 41(4):153-64. PMID: 11698744.
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      83. Afshari MA, Afshari N, Fulton AB. Cortical visual impairment in infants and children. Int Ophthalmol Clin. 2001; 41(1):159-69. PMID: 11198143.
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      84. Afshari N, Afshari MA, Lessell S. Temporal arteritis. Int Ophthalmol Clin. 2001; 41(1):151-8. PMID: 11198142.
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      85. Afshari N, Mullally JE, Afshari MA, Steinert RF, Adamis AP, Azar DT, Talamo JH, Dohlman CH, Dryja TP. Survey of patients with granular, lattice, avellino, and Reis-Bücklers corneal dystrophies for mutations in the BIGH3 and gelsolin genes. Arch Ophthalmol. 2001 Jan; 119(1):16-22. PMID: 11146721.
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      86. Abbas MA, Afshari N, Stadius ML, Kernoff RS, Fischell TA. External beam irradiation inhibits neointimal hyperplasia following balloon angioplasty. Int J Cardiol. 1994 May; 44(3):191-202. PMID: 8077065.
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      87. Ingram RT, Afshari N, Nicoll CS. Binding of intact and cleaved human growth hormone to hepatic receptors and plasma binding proteins. Endocrinology. 1992 May; 130(5):3085-91. PMID: 1533365.
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