John Guatelli

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    High-Throughput Screening for Multifunctional Nef Inhibitors: Targeting HIV through Revitalizing Immune Defense Mechanisms
    NIH R21AI152868Mar 1, 2020 - Feb 28, 2022
    Role: Co-Principal Investigator
    Enhancement of Infectivity by HIV-1 Nef via Antagonism of SERINC Proteins
    NIH R01AI129706Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Activating Latently Infected Cells Using Specific Antigens Including Those of HIV-1
    NIH R33AI116194Jan 19, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Activating Latently Infected Cells Using Specific Antigens Including Those of HIV-1
    NIH R21AI116194Jan 19, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Involvement of the C-terminus of HIV-1 Vpu in Enhancement of Virion Release
    NIH R21AI114397Aug 5, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Inhibiting Immune Evasion by HIV-1 Nef to Facilitate Eradication
    NIH R21AI110162Dec 1, 2013 - Sep 30, 2016
    Role: Principal Investigator
    Viral Hijacking of Host Membrane Trafficking Pathways
    NIH R01AI102778Jan 1, 2013 - Jun 30, 2019
    Role: Principal Investigator
    HIV-1 Vpu and BST-2/CD317
    NIH R37AI081668Dec 1, 2008 - Nov 30, 2023
    Role: Principal Investigator
    HIV-1 Vpu and BST-2/CD317
    NIH R01AI081668Dec 1, 2008 - Nov 30, 2013
    Role: Principal Investigator
    The MHC-I, HIV-1 Nef, AP-1 Complex
    NIH R21AI076040Sep 30, 2007 - Aug 31, 2010
    Role: Principal Investigator
    HIV 1 Nef and Viral Infectivity
    NIH R01AI038201Aug 15, 1996 - Jan 31, 2015
    Role: Principal Investigator
    HIV 1 NEF and Infectivity
    NIH R21AI038201Aug 15, 1996 - Jul 31, 2004
    Role: Principal Investigator
    HOPE Training Grant
    NIH T32AI007384Aug 1, 1990 - Aug 31, 2026
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reply to: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection. Nat Chem Biol. 2023 Nov; 19(11):1306-1308. Oh CK, Piña-Crespo J, Talantova M, Carnevale LN, Stoneham C, Lewinski M, Guatelli J, Lipton SA. PMID: 37798355.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation. Viruses. 2023 02 28; 15(3). Firrito C, Bertelli C, Rosa A, Chande A, Ananth S, van Dijk H, Fackler OT, Stoneham C, Singh R, Guatelli J, Pizzato M. PMID: 36992361; PMCID: PMC10057511.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells. Virology. 2023 01; 578:154-162. Ramirez PW, Vollbrecht T, Acosta FM, Suarez M, Angerstein AO, Wallace J, O' Connell RM, Guatelli J. PMID: 36577173; PMCID: PMC10484624.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Comparative Analysis of T-Cell Spatial Proteomics and the Influence of HIV Expression. Mol Cell Proteomics. 2022 03; 21(3):100194. Oom AL, Stoneham CA, Lewinski MK, Richards A, Wozniak JM, Shams-Ud-Doha K, Gonzalez DJ, Krogan NJ, Guatelli J. PMID: 35017099; PMCID: PMC8956815.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor. PLoS Pathog. 2021 11; 17(11):e1009409. Stoneham CA, Langer S, De Jesus PD, Wozniak JM, Lapek J, Deerinck T, Thor A, Pache L, Chanda SK, Gonzalez DJ, Ellisman M, Guatelli J. PMID: 34843601; PMCID: PMC8659692.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity. PLoS Pathog. 2021 05; 17(5):e1009519. Park SH, Siddiqi H, Castro DV, De Angelis AA, Oom AL, Stoneham CA, Lewinski MK, Clark AE, Croker BA, Carlin AF, Guatelli J, Opella SJ. PMID: 34003853; PMCID: PMC8184013.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    7. Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell. 2021 06 17; 81(12):2656-2668.e8. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. PMID: 33930332; PMCID: PMC8043580.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    8. Corrigendum to "Sensitivity to monoclonal antibody 447-52D and an open env trimer conformation correlate poorly with inhibition of HIV-1 infectivity by SERINC5" [Virology 2020 548, 73-81]. Virology. 2021 May; 557:100. Angerstein AO, Stoneham CA, Ramirez PW, Guatelli JC, Vollbrecht T. PMID: 33581863.
      View in: PubMed   Mentions:    Fields:    
    9. Inconsistent reversal of HIV-1 latency ex vivo by antigens of HIV-1, CMV, and other infectious agents. Retrovirology. 2020 11 23; 17(1):36. Vollbrecht T, Angerstein AO, Menke B, Kumar NM, de Oliveira MF, Richman DD, Guatelli JC. PMID: 33228686; PMCID: PMC7684880.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Functional Landscape of SARS-CoV-2 Cellular Restriction. bioRxiv. 2020 Sep 30. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Pratt D, Churas C, Rosenthal SB, Liu S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Oom AL, Miorin L, Rodriguez-Frandsen A, Urbanowski M, Shaw ML, Chang MW, Benner C, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. PMID: 33024967; PMCID: PMC7536870.
      View in: PubMed   Mentions:
    11. Structural basis of CD4 downregulation by HIV-1 Nef. Nat Struct Mol Biol. 2020 09; 27(9):822-828. Kwon Y, Kaake RM, Echeverria I, Suarez M, Karimian Shamsabadi M, Stoneham C, Ramirez PW, Kress J, Singh R, Sali A, Krogan N, Guatelli J, Jia X. PMID: 32719457; PMCID: PMC7483821.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    12. Sensitivity to monoclonal antibody 447-52D and an open env trimer conformation correlate poorly with inhibition of HIV-1 infectivity by SERINC5. Virology. 2020 09; 548:73-81. Angerstein AO, Stoneham CA, Ramirez PW, Guatelli JC, Vollbrecht T. PMID: 32838948; PMCID: PMC7447835.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef. J Virol. 2020 03 17; 94(7). Stoneham CA, Ramirez PW, Singh R, Suarez M, Debray A, Lim C, Jia X, Xiong Y, Guatelli J. PMID: 31941773; PMCID: PMC7081897.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. Cells. 2019 09 02; 8(9). Ramirez PW, Sharma S, Singh R, Stoneham CA, Vollbrecht T, Guatelli J. PMID: 31480747; PMCID: PMC6770538.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    15. The C-Terminal End of HIV-1 Vpu Has a Clade-Specific Determinant That Antagonizes BST-2 and Facilitates Virion Release. J Virol. 2019 06 01; 93(11). Sharma S, Jafari M, Bangar A, William K, Guatelli J, Lewinski MK. PMID: 30867310; PMCID: PMC6532089.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. An N-Glycosylated Form of SERINC5 Is Specifically Incorporated into HIV-1 Virions. J Virol. 2018 11 15; 92(22). Sharma S, Lewinski MK, Guatelli J. PMID: 30158294; PMCID: PMC6206478.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    17. Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes. J Biol Chem. 2018 10 05; 293(40):15678-15690. Singh R, Stoneham C, Lim C, Jia X, Guenaga J, Wyatt R, Wertheim JO, Xiong Y, Guatelli J. PMID: 30135209; PMCID: PMC6177606.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Cooperation of the Ebola Virus Proteins VP40 and GP1,2 with BST2 To Activate NF-κB Independently of Virus-Like Particle Trapping. J Virol. 2017 11 15; 91(22). Rizk MG, Basler CF, Guatelli J. PMID: 28878074; PMCID: PMC5660480.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors. Traffic. 2017 08; 18(8):545-561. Stoneham CA, Singh R, Jia X, Xiong Y, Guatelli J. PMID: 28504462; PMCID: PMC5600163.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr. Mol Cell Proteomics. 2017 08; 16(8):1447-1461. Lapek JD, Lewinski MK, Wozniak JM, Guatelli J, Gonzalez DJ. PMID: 28606917; PMCID: PMC5546197.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    21. The Evolutionary Histories of Antiretroviral Proteins SERINC3 and SERINC5 Do Not Support an Evolutionary Arms Race in Primates. J Virol. 2016 09 15; 90(18):8085-9. Murrell B, Vollbrecht T, Guatelli J, Wertheim JO. PMID: 27356902; PMCID: PMC5008085.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    22. Non-degradative Ubiquitination of Protein Kinases. PLoS Comput Biol. 2016 06; 12(6):e1004898. Ball KA, Johnson JR, Lewinski MK, Guatelli J, Verschueren E, Krogan NJ, Jacobson MP. PMID: 27253329; PMCID: PMC4890936.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015 Dec 16; 90(5):2486-502. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. PMID: 26676780; PMCID: PMC4810708.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly. J Biol Chem. 2015 Apr 24; 290(17):10919-33. Lewinski MK, Jafari M, Zhang H, Opella SJ, Guatelli J. PMID: 25759385; PMCID: PMC4409254.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    25. Long-term persistence of zoster vaccine efficacy. Clin Infect Dis. 2015 Mar 15; 60(6):900-9. Morrison VA, Johnson GR, Schmader KE, Levin MJ, Zhang JH, Looney DJ, Betts R, Gelb L, Guatelli JC, Harbecke R, Pachucki C, Keay S, Menzies B, Griffin MR, Kauffman CA, Marques A, Toney J, Boardman K, Su SC, Li X, Chan IS, Parrino J, Annunziato P, Oxman MN, Shingles Prevention Study Group. PMID: 25416754; PMCID: PMC4357816.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansPHPublic Health
    26. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife. 2014 Apr 29; 3:e02362. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J, Xiong Y. PMID: 24843023; PMCID: PMC4018625.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    27. Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release. J Virol. 2014 May; 88(9):5062-78. Jafari M, Guatelli J, Lewinski MK. PMID: 24574397; PMCID: PMC3993827.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    28. Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. J Virol. 2014 Jan; 88(1):763-7. Abdel-Mohsen M, Deng X, Liegler T, Guatelli JC, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK. PMID: 24155399; PMCID: PMC3911728.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    29. HIV latency and integration site placement in five cell-based models. Retrovirology. 2013 Aug 16; 10:90. Sherrill-Mix S, Lewinski MK, Famiglietti M, Bosque A, Malani N, Ocwieja KE, Berry CC, Looney D, Shan L, Agosto LM, Pace MJ, Siliciano RF, O'Doherty U, Guatelli J, Planelles V, Bushman FD. PMID: 23953889; PMCID: PMC3765678.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    30. Safety of zoster vaccine in elderly adults following documented herpes zoster. J Infect Dis. 2013 Aug 15; 208(4):559-63. Morrison VA, Oxman MN, Levin MJ, Schmader KE, Guatelli JC, Betts RF, Gelb LD, Pachucki CT, Keay SK, Menzies B, Griffin MR, Kauffman CA, Marques AR, Toney JF, Simberkoff MS, Serrao R, Arbeit RD, Gnann JW, Greenberg RN, Holodniy M, Keitel WA, Yeh SS, Davis LE, Crawford GE, Neuzil KM, Johnson GR, Zhang JH, Harbecke R, Chan IS, Keller PM, Williams HM, Boardman KD, Silber JL, Annunziato PW, Shingles Prevention Study Group. PMID: 23633406; PMCID: PMC3719896.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    31. Stimulation of NF-κB activity by the HIV restriction factor BST2. J Virol. 2013 Feb; 87(4):2046-57. Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R, Guatelli J. PMID: 23221546; PMCID: PMC3571454.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    32. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 09; 5(245):ra73. Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A. PMID: 23047923.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy. Clin Infect Dis. 2012 Nov 15; 55(10):1320-8. Schmader KE, Oxman MN, Levin MJ, Johnson G, Zhang JH, Betts R, Morrison VA, Gelb L, Guatelli JC, Harbecke R, Pachucki C, Keay S, Menzies B, Griffin MR, Kauffman C, Marques A, Toney J, Keller PM, Li X, Chan IS, Annunziato P, Shingles Prevention Study Group. PMID: 22828595; PMCID: PMC4542855.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansPHPublic Health
    34. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol. 2012 Jun 17; 19(7):701-6. Jia X, Singh R, Homann S, Yang H, Guatelli J, Xiong Y. PMID: 22705789; PMCID: PMC3407041.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    35. Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK, Swiss HIV Cohort Study. PMID: 22315404; PMCID: PMC3286922.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    36. HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions. J Biol Chem. 2012 Jan 02; 287(1):58-67. Skasko M, Wang Y, Tian Y, Tokarev A, Munguia J, Ruiz A, Stephens EB, Opella SJ, Guatelli J. PMID: 22072710; PMCID: PMC3249111.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    37. Upregulation of BST-2/Tetherin by HIV infection in vivo. J Virol. 2011 Oct; 85(20):10659-68. Homann S, Smith D, Little S, Richman D, Guatelli J. PMID: 21849457; PMCID: PMC3187519.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    38. Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens. J Virol. 2011 Oct; 85(19):9834-46. Lau D, Kwan W, Guatelli J. PMID: 21813615; PMCID: PMC3196438.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    39. Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. Cell Logist. 2011 May; 1(3):90-102. Tokarev A, Guatelli J. PMID: 21922073; PMCID: PMC3173656.
      View in: PubMed   Mentions: 35  
    40. BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. Virology. 2011 Mar 01; 411(1):65-77. Skasko M, Tokarev A, Chen CC, Fischer WB, Pillai SK, Guatelli J. PMID: 21237475; PMCID: PMC3086044.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    41. Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu. J Virol. 2011 Jan; 85(1):51-63. Tokarev AA, Munguia J, Guatelli JC. PMID: 20980512; PMCID: PMC3014196.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    42. BST-2 mediated restriction of simian-human immunodeficiency virus. Virology. 2010 Oct 25; 406(2):312-21. Ruiz A, Lau D, Mitchell RS, Hill MS, Schmitt K, Guatelli JC, Stephens EB. PMID: 20708210; PMCID: PMC4104713.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    43. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. 2010 Sep; 18(9):388-96. Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. PMID: 20688520; PMCID: PMC2956607.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    44. Tetherin restricts productive HIV-1 cell-to-cell transmission. PLoS Pathog. 2010 Jun 17; 6(6):e1000955. Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O. PMID: 20585562; PMCID: PMC2887479.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    45. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology. 2010 Jun 07; 7:51. Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli JC, Cannon PM. PMID: 20529266; PMCID: PMC2890665.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    46. The Vpu protein: new concepts in virus release and CD4 down-modulation. Curr HIV Res. 2010 Apr; 8(3):240-52. Ruiz A, Guatelli JC, Stephens EB. PMID: 20201792; PMCID: PMC4290667.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    47. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog. 2010 Mar 05; 6(3):e1000701. Fitzpatrick K, Skasko M, Deerinck TJ, Crum J, Ellisman MH, Guatelli J. PMID: 20221443; PMCID: PMC2832767.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    48. How innate immunity can inhibit the release of HIV-1 from infected cells. N Engl J Med. 2010 Feb 11; 362(6):553-4. Guatelli J. PMID: 20147723.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    49. BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog. 2009 Dec; 5(12):e1000700. Miyakawa K, Ryo A, Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yamamoto N. PMID: 20019814; PMCID: PMC2788703.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    50. An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex. PLoS One. 2009 Dec 18; 4(12):e8364. Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli JC. PMID: 20020046; PMCID: PMC2791223.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    51. Antiviral activity of the interferon-induced cellular protein BST-2/tetherin. AIDS Res Hum Retroviruses. 2009 Dec; 25(12):1197-210. Tokarev A, Skasko M, Fitzpatrick K, Guatelli J. PMID: 19929170; PMCID: PMC2858902.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    52. Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog. 2009 May; 5(5):e1000450. Mitchell RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D, Ruiz A, Stephens EB, Margottin-Goguet F, Benarous R, Guatelli JC. PMID: 19478868; PMCID: PMC2679223.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansCells
    53. Interactions of viral protein U (Vpu) with cellular factors. Curr Top Microbiol Immunol. 2009; 339:27-45. Guatelli JC. PMID: 20012522.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    54. Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in virus release. Virology. 2008 Aug 15; 378(1):58-68. Ruiz A, Hill MS, Schmitt K, Guatelli J, Stephens EB. PMID: 18579178; PMCID: PMC4104992.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    55. Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef. J Virol. 2008 Aug; 82(16):7758-67. Mitchell RS, Chaudhuri R, Lindwasser OW, Tanaka KA, Lau D, Murillo R, Bonifacino JS, Guatelli JC. PMID: 18524831; PMCID: PMC2519569.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    56. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe. 2008 Apr 17; 3(4):245-52. Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, Stephens EB, Guatelli J. PMID: 18342597; PMCID: PMC2474773.
      View in: PubMed   Mentions: 686     Fields:    Translation:HumansCells
    57. HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes. Cell Microbiol. 2008 May; 10(5):1040-57. Van Damme N, Guatelli J. PMID: 18076669.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    58. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol. 2008 Feb; 82(3):1249-58. Noviello CM, Benichou S, Guatelli JC. PMID: 18057255; PMCID: PMC2224416.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    59. Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1. J Virol. 2007 May; 81(9):4776-86. Noviello CM, Pond SL, Lewis MJ, Richman DD, Pillai SK, Yang OO, Little SJ, Smith DM, Guatelli JC. PMID: 17329339; PMCID: PMC1900175.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    60. Evidence against a direct antiviral activity of the proteasome during the early steps of HIV-1 replication. Virology. 2007 Apr 25; 361(1):1-8. Dueck M, Guatelli J. PMID: 17316734; PMCID: PMC2753395.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    61. Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane. Traffic. 2007 Jan; 8(1):61-76. Burtey A, Rappoport JZ, Bouchet J, Basmaciogullari S, Guatelli J, Simon SM, Benichou S, Benmerah A. PMID: 17140399.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    62. The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120. Virology. 2006 Oct 25; 354(2):316-27. Day JR, Van Damme N, Guatelli JC. PMID: 16905171.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    63. A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay. J Virol Methods. 2006 Oct; 137(1):125-33. Day JR, Martínez LE, Sásik R, Hitchin DL, Dueck ME, Richman DD, Guatelli JC. PMID: 16876264.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    64. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J Virol. 2006 Feb; 80(4):1837-49. Coleman SH, Madrid R, Van Damme N, Mitchell RS, Bouchet J, Servant C, Pillai S, Benichou S, Guatelli JC. PMID: 16439540; PMCID: PMC1367136.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    65. HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. Virology. 2006 Feb 05; 345(1):148-55. Coleman SH, Hitchin D, Noviello CM, Guatelli JC. PMID: 16253302.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    66. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005 Jun 02; 352(22):2271-84. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL, Shingles Prevention Study Group. PMID: 15930418.
      View in: PubMed   Mentions: 728     Fields:    Translation:HumansCellsCTClinical Trials
    67. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. J Virol. 2005 Feb; 79(4):2066-78. Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC. PMID: 15681409; PMCID: PMC546596.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    68. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem. 2005 Feb 11; 280(6):5032-44. Madrid R, Janvier K, Hitchin D, Day J, Coleman S, Noviello C, Bouchet J, Benmerah A, Guatelli J, Benichou S. PMID: 15569681.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    69. The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus type 1 gp41 is required for optimal viral infectivity. J Virol. 2004 Feb; 78(3):1069-79. Day JR, Münk C, Guatelli JC. PMID: 14722262; PMCID: PMC321364.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    70. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. Ali A, Pillai S, Ng H, Lubong R, Richman DD, Jamieson BD, Ding Y, McElrath MJ, Guatelli JC, Yang OO. PMID: 14530319.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    71. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. J Biol Chem. 2003 Mar 07; 278(10):8725-32. Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J. PMID: 12486136.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    72. Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J Virol. 2001 Apr; 75(8):3971-6. Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S. PMID: 11264386; PMCID: PMC114888.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    73. The HIV-1 Nef protein as a target for antiretroviral therapy. Expert Opin Ther Targets. 2001 Feb; 5(1):1-22. Coleman SH, Day JR, Guatelli JC. PMID: 15992165.
      View in: PubMed   Mentions: 11     Fields:    
    74. Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology. 2000 May 25; 271(1):9-17. Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC. PMID: 10814565.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    75. Analysis of the SH3-binding region of HIV-1 nef: partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket. Virology. 1999 Sep 15; 262(1):55-63. Craig HM, Pandori MW, Riggs NL, Richman DD, Guatelli JC. PMID: 10489340.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    76. The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC. Virology. 1999 Jun 05; 258(2):203-7. Riggs NL, Craig HM, Pandori MW, Guatelli JC. PMID: 10366557.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    77. Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation. Virology. 1998 Nov 25; 251(2):302-16. Pandori M, Craig H, Moutouh L, Corbeil J, Guatelli J. PMID: 9837795.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    78. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11229-34. Craig HM, Pandori MW, Guatelli JC. PMID: 9736718; PMCID: PMC21624.
      View in: PubMed   Mentions: 124     Fields:    Translation:Cells
    79. Cell-associated viral RNA expression during acute infection with HIV type 1. AIDS Res Hum Retroviruses. 1998 Sep 01; 14(13):1141-9. Riggs NL, Little SJ, Richman DD, Guatelli JC. PMID: 9737585.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    80. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. J Virol. 1998 Mar; 72(3):2422-8. Günthard HF, Wong JK, Ignacio CC, Guatelli JC, Riggs NL, Havlir DV, Richman DD. PMID: 9499103; PMCID: PMC109542.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCellsCTClinical Trials
    81. The positive influence of Nef on viral infectivity. Res Virol. 1997 Jan-Feb; 148(1):34-7. Guatelli JC. PMID: 9017831.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    82. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J Virol. 1996 Jul; 70(7):4283-90. Pandori MW, Fitch NJ, Craig HM, Richman DD, Spina CA, Guatelli JC. PMID: 8676450; PMCID: PMC190360.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
    83. Production and characterization of high-titer stocks of rev-defective HIV-1. Virology. 1996 Mar 15; 217(2):602-6. Riggs NL, Guatelli JC. PMID: 8610453.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    84. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology. 1995 Oct 01; 212(2):451-7. Chowers MY, Pandori MW, Spina CA, Richman DD, Guatelli JC. PMID: 7571414.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    85. Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro. J Virol. 1995 May; 69(5):2977-88. Spina CA, Guatelli JC, Richman DD. PMID: 7707524; PMCID: PMC188997.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    86. Tat-independent replication of human immunodeficiency viruses. J Clin Invest. 1995 Jan; 95(1):328-32. Luznik L, Kraus G, Guatelli J, Richman D, Wong-Staal F. PMID: 7814633; PMCID: PMC295435.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    87. Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1. Virology. 1994 Dec; 205(2):578-82. Little SJ, Riggs NL, Chowers MY, Fitch NJ, Richman DD, Spina CA, Guatelli JC. PMID: 7975260.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    88. Biological importance and cooperativity of HIV-1 regulatory gene splice acceptors. Virology. 1994 Jul; 202(1):264-71. Riggs NL, Little SJ, Richman DD, Guatelli JC. PMID: 8009838.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    89. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J Virol. 1994 May; 68(5):2906-14. Chowers MY, Spina CA, Kwoh TJ, Fitch NJ, Richman DD, Guatelli JC. PMID: 8151761; PMCID: PMC236779.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    90. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med. 1994 Jan 01; 179(1):115-23. Spina CA, Kwoh TJ, Chowers MY, Guatelli JC, Richman DD. PMID: 7903679; PMCID: PMC2191324.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    91. Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes. J Virol. 1993 Jun; 67(6):3199-207. Bahner I, Zhou C, Yu XJ, Hao QL, Guatelli JC, Kohn DB. PMID: 8388497; PMCID: PMC237659.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    92. Mechanisms for the inhibition of HIV replication by interferons-alpha, -beta, and -gamma in primary human macrophages. Virology. 1993 Mar; 193(1):138-48. Meylan PR, Guatelli JC, Munis JR, Richman DD, Kornbluth RS. PMID: 7679856.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    93. Ordered appearance of human immunodeficiency virus type 1 nucleic acids following high multiplicity infection of macrophages. J Gen Virol. 1992 Aug; 73 ( Pt 8):1899-906. Munis JR, Kornbluth RS, Guatelli JC, Richman DD. PMID: 1645135.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    94. Use of self-sustained sequence replication amplification reaction to analyze and detect mutations in zidovudine-resistant human immunodeficiency virus. J Infect Dis. 1991 Dec; 164(6):1066-74. Gingeras TR, Prodanovich P, Latimer T, Guatelli JC, Richman DD, Barringer KJ. PMID: 1955709.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    95. Detection of mutations associated with zidovudine resistance in human immunodeficiency virus by use of the polymerase chain reaction. J Infect Dis. 1991 Dec; 164(6):1075-81. Richman DD, Guatelli JC, Grimes J, Tsiatis A, Gingeras T. PMID: 1720152.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    96. Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7797. Guatelli JC, Whitfield KM, Kwoh DY, Barringer KJ, Richman DD, Gingeras TR. PMID: 2217213; PMCID: PMC516580.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    97. Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cells. J Virol. 1990 Sep; 64(9):4093-8. Guatelli JC, Gingeras TR, Richman DD. PMID: 2384914; PMCID: PMC247871.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    98. Methodologies for in vitro nucleic acid amplification and their applications. Vet Microbiol. 1990 Sep; 24(3-4):235-51. Gingeras TR, Richman DD, Kwoh DY, Guatelli JC. PMID: 1701942.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    99. Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication. Proc Natl Acad Sci U S A. 1990 Mar; 87(5):1874-8. Guatelli JC, Whitfield KM, Kwoh DY, Barringer KJ, Richman DD, Gingeras TR. PMID: 2308948; PMCID: PMC53586.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    100. Nucleic acid amplification in vitro: detection of sequences with low copy numbers and application to diagnosis of human immunodeficiency virus type 1 infection. Clin Microbiol Rev. 1989 Apr; 2(2):217-26. Guatelli JC, Gingeras TR, Richman DD. PMID: 2650862; PMCID: PMC358112.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    101. Study on the dehydrating effect of the red cell Na+/K+-pump in nystatin-treated cells with varying Na+ and water contents. Biochim Biophys Acta. 1981 Sep 07; 646(3):422-32. Clark MR, Guatelli JC, White AT, Shohet SB. PMID: 7284370.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    102. Influence of red cell water content on the morphology of sickling. Blood. 1980 May; 55(5):823-30. Clark MR, Guatelli JC, Mohandas N, Shohet SB. PMID: 6767510.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    103. The spectrin phosphorylation reaction in human erythrocytes. Prog Clin Biol Res. 1978; 20:1-24. Greenquist AC, Wyatt JL, Guatelli JC, Shohet SB. PMID: 652813.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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