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John Guatelli

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0679
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    Enhancement of Infectivity by HIV-1 Nef via Antagonism of SERINC Proteins
    NIH/NIAID R01AI129706Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Activating Latently Infected Cells Using Specific Antigens Including Those of HIV-1
    NIH/NIAID R33AI116194Jan 19, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Activating Latently Infected Cells Using Specific Antigens Including Those of HIV-1
    NIH/NIAID R21AI116194Jan 19, 2016 - Dec 31, 2017
    Role: Principal Investigator
    Involvement of the C-terminus of HIV-1 Vpu in Enhancement of Virion Release
    NIH/NIAID R21AI114397Aug 5, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Inhibiting Immune Evasion by HIV-1 Nef to Facilitate Eradication
    NIH/NIAID R21AI110162Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    Viral Hijacking of Host Membrane Trafficking Pathways
    NIH/NIAID R01AI102778Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    HIV-1 Vpu and BST-2/CD317
    NIH/NIAID R37AI081668Dec 1, 2008 - Nov 30, 2018
    Role: Principal Investigator
    HIV-1 Vpu and BST-2/CD317
    NIH/NIAID R01AI081668Dec 1, 2008 - Nov 30, 2013
    Role: Principal Investigator
    The MHC-I, HIV-1 Nef, AP-1 Complex
    NIH/NIAID R21AI076040Sep 30, 2007 - Aug 31, 2010
    Role: Principal Investigator
    HIV 1 Nef and Viral Infectivity
    NIH/NIAID R01AI038201Aug 15, 1996 - Jan 31, 2015
    Role: Principal Investigator
    HIV 1 NEF and Infectivity
    NIH/NIAID R21AI038201Aug 15, 1996 - Jul 31, 2004
    Role: Principal Investigator
    AIDS Training Grant
    NIH/NIAID T32AI007384Aug 1, 1990 - Aug 31, 2021
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sharma S, Lewinski MK, Guatelli J. An N-glycosylated form of SERINC5 is specifically incorporated into HIV-1 virions. J Virol. 2018 Aug 29. PMID: 30158294.
      View in: PubMed
    2. Singh R, Stoneham C, Lim C, Jia X, Guenaga J, Wyatt R, Wertheim JO, Xiong Y, Guatelli J. Phosphoserine acidic cluster motifs bind distinct basic regions on the µ subunits of clathrin adaptor protein complexes. J Biol Chem. 2018 Aug 22. PMID: 30135209.
      View in: PubMed
    3. Rizk MG, Basler CF, Guatelli J. Cooperation of the Ebola Virus Proteins VP40 and GP1,2 with BST2 To Activate NF-?B Independently of Virus-Like Particle Trapping. J Virol. 2017 11 15; 91(22). PMID: 28878074.
      View in: PubMed
    4. Stoneham CA, Singh R, Jia X, Xiong Y, Guatelli J. Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors. Traffic. 2017 08; 18(8):545-561. PMID: 28504462.
      View in: PubMed
    5. Lapek JD, Lewinski MK, Wozniak JM, Guatelli J, Gonzalez DJ. Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr. Mol Cell Proteomics. 2017 Aug; 16(8):1447-1461. PMID: 28606917.
      View in: PubMed
    6. Murrell B, Vollbrecht T, Guatelli J, Wertheim JO. The Evolutionary Histories of Antiretroviral Proteins SERINC3 and SERINC5 Do Not Support an Evolutionary Arms Race in Primates. J Virol. 2016 09 15; 90(18):8085-9. PMID: 27356902; PMCID: PMC5008085 [Available on 02/26/17].
    7. Ball KA, Johnson JR, Lewinski MK, Guatelli J, Verschueren E, Krogan NJ, Jacobson MP. Non-degradative Ubiquitination of Protein Kinases. PLoS Comput Biol. 2016 06; 12(6):e1004898. PMID: 27253329; PMCID: PMC4890936.
    8. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015 Dec 16; 90(5):2486-502. PMID: 26676780; PMCID: PMC4810708.
    9. Lewinski MK, Jafari M, Zhang H, Opella SJ, Guatelli J. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly. J Biol Chem. 2015 Apr 24; 290(17):10919-33. PMID: 25759385; PMCID: PMC4409254.
    10. Morrison VA, Johnson GR, Schmader KE, Levin MJ, Zhang JH, Looney DJ, Betts R, Gelb L, Guatelli JC, Harbecke R, Pachucki C, Keay S, Menzies B, Griffin MR, Kauffman CA, Marques A, Toney J, Boardman K, Su SC, Li X, Chan IS, Parrino J, Annunziato P, Oxman MN. Long-term persistence of zoster vaccine efficacy. Clin Infect Dis. 2015 Mar 15; 60(6):900-9. PMID: 25416754; PMCID: PMC4357816.
    11. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J, Xiong Y. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife. 2014 Apr 29; 3:e02362. PMID: 24843023; PMCID: PMC4018625.
    12. Jafari M, Guatelli J, Lewinski MK. Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release. J Virol. 2014 May; 88(9):5062-78. PMID: 24574397; PMCID: PMC3993827.
    13. Abdel-Mohsen M, Deng X, Liegler T, Guatelli JC, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK. Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. J Virol. 2014 Jan; 88(1):763-7. PMID: 24155399; PMCID: PMC3911728.
    14. Sherrill-Mix S, Lewinski MK, Famiglietti M, Bosque A, Malani N, Ocwieja KE, Berry CC, Looney D, Shan L, Agosto LM, Pace MJ, Siliciano RF, O'Doherty U, Guatelli J, Planelles V, Bushman FD. HIV latency and integration site placement in five cell-based models. Retrovirology. 2013 Aug 16; 10:90. PMID: 23953889; PMCID: PMC3765678.
    15. Morrison VA, Oxman MN, Levin MJ, Schmader KE, Guatelli JC, Betts RF, Gelb LD, Pachucki CT, Keay SK, Menzies B, Griffin MR, Kauffman CA, Marques AR, Toney JF, Simberkoff MS, Serrao R, Arbeit RD, Gnann JW, Greenberg RN, Holodniy M, Keitel WA, Yeh SS, Davis LE, Crawford GE, Neuzil KM, Johnson GR, Zhang JH, Harbecke R, Chan IS, Keller PM, Williams HM, Boardman KD, Silber JL, Annunziato PW. Safety of zoster vaccine in elderly adults following documented herpes zoster. J Infect Dis. 2013 Aug 15; 208(4):559-63. PMID: 23633406; PMCID: PMC3719896.
    16. Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R, Guatelli J. Stimulation of NF-?B activity by the HIV restriction factor BST2. J Virol. 2013 Feb; 87(4):2046-57. PMID: 23221546; PMCID: PMC3571454.
    17. Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 09; 5(245):ra73. PMID: 23047923.
      View in: PubMed
    18. Schmader KE, Oxman MN, Levin MJ, Johnson G, Zhang JH, Betts R, Morrison VA, Gelb L, Guatelli JC, Harbecke R, Pachucki C, Keay S, Menzies B, Griffin MR, Kauffman C, Marques A, Toney J, Keller PM, Li X, Chan IS, Annunziato P. Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy. Clin Infect Dis. 2012 Nov 15; 55(10):1320-8. PMID: 22828595; PMCID: PMC4542855.
    19. Jia X, Singh R, Homann S, Yang H, Guatelli J, Xiong Y. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol. 2012 Jun 17; 19(7):701-6. PMID: 22705789; PMCID: PMC3407041.
    20. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. PMID: 22315404; PMCID: PMC3286922.
    21. Skasko M, Wang Y, Tian Y, Tokarev A, Munguia J, Ruiz A, Stephens EB, Opella SJ, Guatelli J. HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions. J Biol Chem. 2012 Jan 02; 287(1):58-67. PMID: 22072710; PMCID: PMC3249111.
    22. Homann S, Smith D, Little S, Richman D, Guatelli J. Upregulation of BST-2/Tetherin by HIV infection in vivo. J Virol. 2011 Oct; 85(20):10659-68. PMID: 21849457; PMCID: PMC3187519.
    23. Lau D, Kwan W, Guatelli J. Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens. J Virol. 2011 Oct; 85(19):9834-46. PMID: 21813615; PMCID: PMC3196438.
    24. Tokarev A, Guatelli J. Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. Cell Logist. 2011 May; 1(3):90-102. PMID: 21922073.
      View in: PubMed
    25. Skasko M, Tokarev A, Chen CC, Fischer WB, Pillai SK, Guatelli J. BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. Virology. 2011 Mar 01; 411(1):65-77. PMID: 21237475; PMCID: PMC3086044.
    26. Tokarev AA, Munguia J, Guatelli JC. Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu. J Virol. 2011 Jan; 85(1):51-63. PMID: 20980512; PMCID: PMC3014196.
    27. Ruiz A, Lau D, Mitchell RS, Hill MS, Schmitt K, Guatelli JC, Stephens EB. BST-2 mediated restriction of simian-human immunodeficiency virus. Virology. 2010 Oct 25; 406(2):312-21. PMID: 20708210; PMCID: PMC4104713.
    28. Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. 2010 Sep; 18(9):388-96. PMID: 20688520; PMCID: PMC2956607.
    29. Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O. Tetherin restricts productive HIV-1 cell-to-cell transmission. PLoS Pathog. 2010 Jun 17; 6(6):e1000955. PMID: 20585562; PMCID: PMC2887479.
    30. Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli JC, Cannon PM. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology. 2010 Jun 07; 7:51. PMID: 20529266; PMCID: PMC2890665.
    31. Ruiz A, Guatelli JC, Stephens EB. The Vpu protein: new concepts in virus release and CD4 down-modulation. Curr HIV Res. 2010 Apr; 8(3):240-52. PMID: 20201792; PMCID: PMC4290667.
    32. Fitzpatrick K, Skasko M, Deerinck TJ, Crum J, Ellisman MH, Guatelli J. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog. 2010 Mar 05; 6(3):e1000701. PMID: 20221443; PMCID: PMC2832767.
    33. Guatelli J. How innate immunity can inhibit the release of HIV-1 from infected cells. N Engl J Med. 2010 Feb 11; 362(6):553-4. PMID: 20147723.
      View in: PubMed
    34. Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli JC. An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex. PLoS One. 2009 Dec 18; 4(12):e8364. PMID: 20020046; PMCID: PMC2791223.
    35. Miyakawa K, Ryo A, Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yamamoto N. BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog. 2009 Dec; 5(12):e1000700. PMID: 20019814; PMCID: PMC2788703.
    36. Tokarev A, Skasko M, Fitzpatrick K, Guatelli J. Antiviral activity of the interferon-induced cellular protein BST-2/tetherin. AIDS Res Hum Retroviruses. 2009 Dec; 25(12):1197-210. PMID: 19929170; PMCID: PMC2858902.
    37. Mitchell RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D, Ruiz A, Stephens EB, Margottin-Goguet F, Benarous R, Guatelli JC. Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog. 2009 May; 5(5):e1000450. PMID: 19478868; PMCID: PMC2679223.
    38. Guatelli JC. Interactions of viral protein U (Vpu) with cellular factors. Curr Top Microbiol Immunol. 2009; 339:27-45. PMID: 20012522.
      View in: PubMed
    39. Ruiz A, Hill MS, Schmitt K, Guatelli J, Stephens EB. Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in virus release. Virology. 2008 Aug 15; 378(1):58-68. PMID: 18579178; PMCID: PMC4104992.
    40. Mitchell RS, Chaudhuri R, Lindwasser OW, Tanaka KA, Lau D, Murillo R, Bonifacino JS, Guatelli JC. Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef. J Virol. 2008 Aug; 82(16):7758-67. PMID: 18524831; PMCID: PMC2519569.
    41. Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, Stephens EB, Guatelli J. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe. 2008 Apr 17; 3(4):245-52. PMID: 18342597; PMCID: PMC2474773.
    42. Van Damme N, Guatelli J. HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes. Cell Microbiol. 2008 May; 10(5):1040-57. PMID: 18076669.
      View in: PubMed
    43. Noviello CM, Benichou S, Guatelli JC. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol. 2008 Feb; 82(3):1249-58. PMID: 18057255; PMCID: PMC2224416.
    44. Noviello CM, Pond SL, Lewis MJ, Richman DD, Pillai SK, Yang OO, Little SJ, Smith DM, Guatelli JC. Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1. J Virol. 2007 May; 81(9):4776-86. PMID: 17329339; PMCID: PMC1900175.
    45. Dueck M, Guatelli J. Evidence against a direct antiviral activity of the proteasome during the early steps of HIV-1 replication. Virology. 2007 Apr 25; 361(1):1-8. PMID: 17316734; PMCID: PMC2753395.
    46. Burtey A, Rappoport JZ, Bouchet J, Basmaciogullari S, Guatelli J, Simon SM, Benichou S, Benmerah A. Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane. Traffic. 2007 Jan; 8(1):61-76. PMID: 17140399.
      View in: PubMed
    47. Day JR, Van Damme N, Guatelli JC. The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120. Virology. 2006 Oct 25; 354(2):316-27. PMID: 16905171.
      View in: PubMed
    48. Day JR, Martínez LE, Sásik R, Hitchin DL, Dueck ME, Richman DD, Guatelli JC. A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay. J Virol Methods. 2006 Oct; 137(1):125-33. PMID: 16876264.
      View in: PubMed
    49. Coleman SH, Madrid R, Van Damme N, Mitchell RS, Bouchet J, Servant C, Pillai S, Benichou S, Guatelli JC. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J Virol. 2006 Feb; 80(4):1837-49. PMID: 16439540; PMCID: PMC1367136.
    50. Coleman SH, Hitchin D, Noviello CM, Guatelli JC. HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. Virology. 2006 Feb 05; 345(1):148-55. PMID: 16253302.
      View in: PubMed
    51. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005 Jun 02; 352(22):2271-84. PMID: 15930418.
      View in: PubMed
    52. Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. J Virol. 2005 Feb; 79(4):2066-78. PMID: 15681409; PMCID: PMC546596.
    53. Madrid R, Janvier K, Hitchin D, Day J, Coleman S, Noviello C, Bouchet J, Benmerah A, Guatelli J, Benichou S. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem. 2005 Feb 11; 280(6):5032-44. PMID: 15569681.
      View in: PubMed
    54. Day JR, Münk C, Guatelli JC. The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus type 1 gp41 is required for optimal viral infectivity. J Virol. 2004 Feb; 78(3):1069-79. PMID: 14722262; PMCID: PMC321364.
    55. Ali A, Pillai S, Ng H, Lubong R, Richman DD, Jamieson BD, Ding Y, McElrath MJ, Guatelli JC, Yang OO. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. PMID: 14530319.
      View in: PubMed
    56. Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. J Biol Chem. 2003 Mar 07; 278(10):8725-32. PMID: 12486136.
      View in: PubMed
    57. Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S. Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J Virol. 2001 Apr; 75(8):3971-6. PMID: 11264386; PMCID: PMC114888.
    58. Coleman SH, Day JR, Guatelli JC. The HIV-1 Nef protein as a target for antiretroviral therapy. Expert Opin Ther Targets. 2001 Feb; 5(1):1-22. PMID: 15992165.
      View in: PubMed
    59. Erdtmann L, Janvier K, Raposo G, Craig HM, Benaroch P, Berlioz-Torrent C, Guatelli JC, Benarous R, Benichou S. Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex. Traffic. 2000 Nov; 1(11):871-83. PMID: 11208076.
      View in: PubMed
    60. Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC. Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology. 2000 May 25; 271(1):9-17. PMID: 10814565.
      View in: PubMed
    61. Craig HM, Pandori MW, Riggs NL, Richman DD, Guatelli JC. Analysis of the SH3-binding region of HIV-1 nef: partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket. Virology. 1999 Sep 15; 262(1):55-63. PMID: 10489340.
      View in: PubMed
    62. Riggs NL, Craig HM, Pandori MW, Guatelli JC. The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC. Virology. 1999 Jun 05; 258(2):203-7. PMID: 10366557.
      View in: PubMed
    63. Pandori M, Craig H, Moutouh L, Corbeil J, Guatelli J. Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation. Virology. 1998 Nov 25; 251(2):302-16. PMID: 9837795.
      View in: PubMed
    64. Craig HM, Pandori MW, Guatelli JC. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11229-34. PMID: 9736718; PMCID: PMC21624.
    65. Riggs NL, Little SJ, Richman DD, Guatelli JC. Cell-associated viral RNA expression during acute infection with HIV type 1. AIDS Res Hum Retroviruses. 1998 Sep 01; 14(13):1141-9. PMID: 9737585.
      View in: PubMed
    66. Günthard HF, Wong JK, Ignacio CC, Guatelli JC, Riggs NL, Havlir DV, Richman DD. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. J Virol. 1998 Mar; 72(3):2422-8. PMID: 9499103; PMCID: PMC109542.
    67. Guatelli JC. The positive influence of Nef on viral infectivity. Res Virol. 1997 Jan-Feb; 148(1):34-7. PMID: 9017831.
      View in: PubMed
    68. Pandori MW, Fitch NJ, Craig HM, Richman DD, Spina CA, Guatelli JC. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J Virol. 1996 Jul; 70(7):4283-90. PMID: 8676450; PMCID: PMC190360.
    69. Riggs NL, Guatelli JC. Production and characterization of high-titer stocks of rev-defective HIV-1. Virology. 1996 Mar 15; 217(2):602-6. PMID: 8610453.
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    70. Chowers MY, Pandori MW, Spina CA, Richman DD, Guatelli JC. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology. 1995 Oct 01; 212(2):451-7. PMID: 7571414.
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    71. Spina CA, Guatelli JC, Richman DD. Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro. J Virol. 1995 May; 69(5):2977-88. PMID: 7707524; PMCID: PMC188997.
    72. Luznik L, Kraus G, Guatelli J, Richman D, Wong-Staal F. Tat-independent replication of human immunodeficiency viruses. J Clin Invest. 1995 Jan; 95(1):328-32. PMID: 7814633; PMCID: PMC295435.
    73. Little SJ, Riggs NL, Chowers MY, Fitch NJ, Richman DD, Spina CA, Guatelli JC. Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1. Virology. 1994 Dec; 205(2):578-82. PMID: 7975260.
      View in: PubMed
    74. Riggs NL, Little SJ, Richman DD, Guatelli JC. Biological importance and cooperativity of HIV-1 regulatory gene splice acceptors. Virology. 1994 Jul; 202(1):264-71. PMID: 8009838.
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    75. Chowers MY, Spina CA, Kwoh TJ, Fitch NJ, Richman DD, Guatelli JC. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J Virol. 1994 May; 68(5):2906-14. PMID: 8151761; PMCID: PMC236779.
    76. Spina CA, Kwoh TJ, Chowers MY, Guatelli JC, Richman DD. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med. 1994 Jan 01; 179(1):115-23. PMID: 7903679; PMCID: PMC2191324.
    77. Bahner I, Zhou C, Yu XJ, Hao QL, Guatelli JC, Kohn DB. Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes. J Virol. 1993 Jun; 67(6):3199-207. PMID: 8388497; PMCID: PMC237659.
    78. Meylan PR, Guatelli JC, Munis JR, Richman DD, Kornbluth RS. Mechanisms for the inhibition of HIV replication by interferons-alpha, -beta, and -gamma in primary human macrophages. Virology. 1993 Mar; 193(1):138-48. PMID: 7679856.
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    79. Munis JR, Kornbluth RS, Guatelli JC, Richman DD. Ordered appearance of human immunodeficiency virus type 1 nucleic acids following high multiplicity infection of macrophages. J Gen Virol. 1992 Aug; 73 ( Pt 8):1899-906. PMID: 1645135.
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