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Jeffrey Esko

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0687
La Jolla CA 92093
Phone858-822-1100
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    Collapse Biography 
    Collapse Awards and Honors
    NIH1999  - 2009MERIT award
    Society for Glycobiology2007Karl Meyer Award
    Uppsala University2010Doctor of Medicine (honoris causa)
    International Glycoconjugate Organization2011IGO award
    American Association for the Advancement of Science2012Elected Fellow
    NIH2013Director's WALS Lecture

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Enhancement of wound healing and regeneration through heparan sulfate deficiency
    NIH/NIAMS R61AR073031Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis
    NIH P01HL131474Jul 15, 2016 - Apr 30, 2021
    Role: Co-Investigator
    5th International MHE Research Conference
    NIH/NIAMS R13AR069987Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator
    Genome-wide Analysis of Heparan Sulfate using CRISPR/Cas9
    NIH/NCI R21CA199292Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Drug Discovery for Multiple Hereditary Exostoses
    NIH/NIAMS R01AR064202Sep 16, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Glycan Modulation of Inflammatory Responses
    NIH P01HL107150Jul 1, 2011 - May 31, 2018
    Role: Co-Investigator
    Structure and Function of 3-O-sulfation in Heparan Sulfate
    NIH/NIGMS R01GM093131May 1, 2010 - Apr 30, 2014
    Role: Principal Investigator
    Gene Discovery and Heparan Sulfate Biogenesis
    NIH/NHLBI R21HL098910Mar 1, 2010 - Dec 31, 2012
    Role: Principal Investigator
    Shared Instrumentation Grant: LTQ Linear Ion Trap Mass Spectrometer
    NIH/NCRR S10RR025507May 1, 2009 - Apr 30, 2010
    Role: Principal Investigator
    Altered endothelial heparan sulfate causes diaphragmatic hernias resembling CDH
    NIH/NICHD R21HD052920May 1, 2006 - Apr 30, 2009
    Role: Principal Investigator
    Glycoside Inhibitors of Tumor Metastasis
    NIH/NCI R01CA112278Feb 9, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Heparan Sulfate--a Novel Target for Cancer Therapeutics
    NIH/NCI U01CA091290Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    GORDON CONFERENCE--PROTEOGLYCANS
    NIH/NIAMS R13AR045230Jul 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    Genetic Modulation of Blood and Vascular Glycosylation
    NIH/NHLBI P01HL057345Sep 30, 1997 - Dec 31, 2013
    Role: Co-Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    GLYCOSIDE ANTAGONISTS OF GLYCOSYLATION
    NIH/NCI R01CA046462Apr 20, 1990 - Jun 30, 2002
    Role: Principal Investigator
    Genetic analysis of proteoglycan-mediated lipoprotein clearance
    NIH/NIGMS R01GM033063Jul 1, 1983 - Apr 30, 2020
    Role: Principal Investigator
    GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    NIH/NIGMS R37GM033063Jul 1, 1983 - Nov 30, 2010
    Role: Principal Investigator
    SCOR IN ACUTE LUNG INJURY
    NIH/NHLBI P50HL023584Dec 1, 1978 - Nov 30, 2003
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gordts PLSM, Esko J. The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biol. 2018 May 24. PMID: 29803939.
      View in: PubMed
    2. Ge XN, Bastan I, Ha SG, Greenberg YG, Esko J, Rao SP, Sriramarao P. Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes. Exp Lung Res. 2018 Mar; 44(2):98-112. PMID: 29621420.
      View in: PubMed
    3. Naini SMA, Yanicostas C, Hassan-Abdi R, Blondeel S, Bennis M, Weiss RJ, Tor Y, Esko J, Soussi-Yanicostas N. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. 2018; 7:6. PMID: 29568517.
      View in: PubMed
    4. Spahn PN, Bath T, Weiss RJ, Kim J, Esko J, Lewis NE, Harismendy O. PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens. Sci Rep. 2017 Nov 20; 7(1):15854. PMID: 29158538.
      View in: PubMed
    5. Phan AQ, Pacifici M, Esko J. Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference. Connect Tissue Res. 2018 Jan; 59(1):85-98. PMID: 29099240.
      View in: PubMed
    6. Hadidi K, Wexselblatt E, Esko J, Tor Y. Cellular uptake of modified aminoglycosides. J Antibiot (Tokyo). 2017 Nov 01. PMID: 29089598.
      View in: PubMed
    7. Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko J, Masliah E. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. 2017 Aug 21; 7(1):9008. PMID: 28827536.
      View in: PubMed
    8. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko J. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. PMID: 28958576.
      View in: PubMed
    9. Weiss RJ, Esko J, Tor Y. Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 2017 Jul 21; 15(27):5656-5668. PMID: 28653068.
      View in: PubMed
    10. Dwyer CA, Scudder SL, Lin Y, Dozier LE, Phan D, Allen NJ, Patrick GN, Esko J. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017 Apr 18; 7:46576. PMID: 28418018.
      View in: PubMed
    11. Dhamale OP, Lawrence R, Wiegmann EM, Shah BA, Al-Mafraji K, Lamanna WC, Lübke T, Dierks T, Boons GJ, Esko J. Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chem Biol. 2017 Feb 17; 12(2):367-373. PMID: 28055182.
      View in: PubMed
    12. van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko J. Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin a2 as a Host Factor for Bacterial Invasion. MBio. 2017 01 10; 8(1). PMID: 28074024.
      View in: PubMed
    13. Hamill KM, Wexselblatt E, Tong W, Esko J, Tor Y. Delivery of Cargo to Lysosomes Using GNeosomes. Methods Mol Biol. 2017; 1594:151-163. PMID: 28456981.
      View in: PubMed
    14. Sganappa A, Wexselblatt E, Bellucci MC, Esko J, Tedeschi G, Tor Y, Volonterio A. Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules. Chembiochem. 2017 Jan 03; 18(1):119-125. PMID: 27806190.
      View in: PubMed
    15. Dwyer CA, Esko J. Glycan susceptibility factors in autism spectrum disorders. Mol Aspects Med. 2016 10; 51:104-14. PMID: 27418189.
      View in: PubMed
    16. Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko J. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 Aug 01; 126(8):2855-66. PMID: 27400128; PMCID: PMC4966320 [Available on 11/01/16].
    17. Hamill KM, McCoy LS, Wexselblatt E, Esko J, Tor Y. Polymyxins Facilitate Entry into Mammalian Cells. Chem Sci. 2016 Aug 01; 7(8):5059-5068. PMID: 28044098.
      View in: PubMed
    18. Khalid O, Vera MU, Gordts PL, Ellinwood NM, Schwartz PH, Dickson PI, Esko J, Wang RY. Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. PLoS One. 2016; 11(3):e0150850. PMID: 26986213; PMCID: PMC4795702.
    19. Thacker BE, Seamen E, Lawrence R, Parker MW, Xu Y, Liu J, Vander Kooi CW, Esko J. Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity. ACS Chem Biol. 2016 Apr 15; 11(4):971-80. PMID: 26731579.
      View in: PubMed
    20. Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko J, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi CR, Etzler ME, Frank M, Vliegenthart JF, Lütteke T, Perez S, Bolton E, Rudd P, Paulson J, Kanehisa M, Toukach P, Aoki-Kinoshita KF, Dell A, Narimatsu H, York W, Taniguchi N, Kornfeld S. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 2015 Dec; 25(12):1323-4. PMID: 26543186; PMCID: PMC4643639 [Available on 12/01/16].
    21. Zaiss AK, Foley EM, Lawrence R, Schneider LS, Hoveida H, Secrest P, Catapang AB, Yamaguchi Y, Alemany R, Shayakhmetov DM, Esko J, Herschman HR. Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo. J Virol. 2016 01 01; 90(1):412-20. PMID: 26491162.
      View in: PubMed
    22. Weiss RJ, Gordts PL, Le D, Xu D, Esko J, Tor Y. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. PMID: 28133533.
      View in: PubMed
    23. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko J, Chang YC. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. PMID: 26150541; PMCID: PMC4534644.
    24. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko J, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. PMID: 25995222.
      View in: PubMed
    25. Marki A, Esko J, Pries AR, Ley K. Role of the endothelial surface layer in neutrophil recruitment. J Leukoc Biol. 2015 Oct; 98(4):503-15. PMID: 25979432; PMCID: PMC4569049 [Available on 10/01/16].
    26. Coulson-Thomas VJ, Chang SH, Yeh LK, Coulson-Thomas YM, Yamaguchi Y, Esko J, Liu CY, Kao W. Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci. 2015 May; 56(5):3004-14. PMID: 26024086; PMCID: PMC4432551.
    27. Wexselblatt E, Esko J, Tor Y. GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery. ACS Nano. 2015; 9(4):3961-8. PMID: 25831231.
      View in: PubMed
    28. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko J, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagiroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015 May; 47(5):528-34. PMID: 25848753; PMCID: PMC4414867.
    29. Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko J, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10; 6:6356. PMID: 25754609; PMCID: PMC4366535.
    30. Mooij HL, Bernelot Moens SJ, Gordts PL, Stanford KI, Foley EM, van den Boogert MA, Witjes JJ, Hassing HC, Tanck MW, van de Sande MA, Levels JH, Kastelein JJ, Stroes ES, Dallinga-Thie GM, Esko J, Nieuwdorp M. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res. 2015 Mar; 56(3):665-73. PMID: 25568062; PMCID: PMC4340313.
    31. Gordts PL, Esko J. Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-ß. Cytokine. 2015 Mar; 72(1):118-9. PMID: 25573804.
      View in: PubMed
    32. Bernelot Moens SJ, Mooij HL, Hassing HC, Kruit JK, Witjes JJ, van de Sande MA, Nederveen AJ, Xu D, Dallinga-Thie GM, Esko J, Stroes ES, Nieuwdorp M. Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume. PLoS One. 2014; 9(12):e115662. PMID: 25541963.
      View in: PubMed
    33. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko J. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. PMID: 25440058.
      View in: PubMed
    34. Wen J, Xiao J, Rahdar M, Choudhury BP, Cui J, Taylor GS, Esko J, Dixon JE. Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15723-8. PMID: 25331875; PMCID: PMC4226115.
    35. Coulson-Thomas VJ, Gesteira TF, Esko J, Kao W. Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem. 2014 Sep 05; 289(36):25211-26. PMID: 25053416; PMCID: PMC4155684.
    36. Wexselblatt E, Esko J, Tor Y. On guanidinium and cellular uptake. J Org Chem. 2014 Aug 01; 79(15):6766-74. PMID: 25019333; PMCID: PMC4120969.
    37. Wang RY, Aminian A, McEntee MF, Kan SH, Simonaro CM, Lamanna WC, Lawrence R, Ellinwood NM, Guerra C, Le SQ, Dickson PI, Esko J. Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I. Mol Genet Metab. 2014 Aug; 112(4):286-93. PMID: 24951454; PMCID: PMC4122635.
    38. Ge XN, Ha SG, Rao A, Greenberg YG, Rushdi MN, Esko J, Rao SP, Sriramarao P. Endothelial and leukocyte heparan sulfates regulate the development of allergen-induced airway remodeling in a mouse model. Glycobiology. 2014 Aug; 24(8):715-27. PMID: 24794009.
      View in: PubMed
    39. Rops AL, Loeven MA, van Gemst JJ, Eversen I, Van Wijk XM, Dijkman HB, van Kuppevelt TH, Berden JH, Rabelink TJ, Esko J, van der Vlag J. Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney Int. 2014 Nov; 86(5):932-42. PMID: 24759151.
      View in: PubMed
    40. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko J, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. PMID: 24726386; PMCID: PMC4143151.
    41. Inoue M, Wexselblatt E, Esko J, Tor Y. Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters. Chembiochem. 2014 Mar 21; 15(5):676-80. PMID: 24677320; PMCID: PMC4216228.
    42. Xu D, Esko J. Demystifying heparan sulfate-protein interactions. Annu Rev Biochem. 2014; 83:129-57. PMID: 24606135.
      View in: PubMed
    43. Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li D, Linhardt RJ, Esko J, Wang L. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan; 124(1):209-21. PMID: 24355925; PMCID: PMC3871243.
    44. Thacker BE, Xu D, Lawrence R, Esko J. Heparan sulfate 3-O-sulfation: a rare modification in search of a function. Matrix Biol. 2014 Apr; 35:60-72. PMID: 24361527; PMCID: PMC4039620.
    45. Gasimli L, Glass CA, Datta P, Yang B, Li G, Gemmill TR, Baik JY, Sharfstein ST, Esko J, Linhardt RJ. Bioengineering murine mastocytoma cells to produce anticoagulant heparin. Glycobiology. 2014 Mar; 24(3):272-80. PMID: 24326668; PMCID: PMC3919470.
    46. Pan Y, Carbe C, Kupich S, Pickhinke U, Ohlig S, Frye M, Seelige R, Pallerla SR, Moon AM, Lawrence R, Esko J, Zhang X, Grobe K. Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis. Matrix Biol. 2014 Apr; 35:253-65. PMID: 24200809; PMCID: PMC4324438.
    47. Sugar T, Wassenhove-McCarthy DJ, Esko J, van Kuppevelt TH, Holzman L, McCarthy KJ. Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo. Kidney Int. 2014 Feb; 85(2):307-18. PMID: 23924956; PMCID: PMC4624314.
    48. Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko J. Glycan-based biomarkers for mucopolysaccharidoses. Mol Genet Metab. 2014 Feb; 111(2):73-83. PMID: 23958290; PMCID: PMC3769472.
    49. Foley EM, Gordts PLSM, Stanford KI, Gonzales JC, Lawrence R, Stoddard N, Esko J. Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2065-74. PMID: 23846497; PMCID: PMC3821931.
    50. Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko J. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013 Jul 19; 8(7):1611-20. PMID: 23679870; PMCID: PMC3806902.
    51. Gonzales JC, Gordts PL, Foley EM, Esko J. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest. 2013 Jun; 123(6):2742-51. PMID: 23676495; PMCID: PMC3668842.
    52. Inoue M, Tong W, Esko J, Tor Y. Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol. 2013 Jul 19; 8(7):1383-8. PMID: 23621420; PMCID: PMC3773245.
    53. Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko J. WITHDRAWN: Glycan-based biomarkers for mucopolysaccharidoses. Dis Markers. 2013 Feb 08. PMID: 23396297.
      View in: PubMed
    54. Cantley L, Saunders C, Guttenberg M, Candela ME, Ohta Y, Yasuhara R, Kondo N, Sgariglia F, Asai S, Zhang X, Qin L, Hecht JT, Chen D, Yamamoto M, Toyosawa S, Dormans JP, Esko J, Yamaguchi Y, Iwamoto M, Pacifici M, Enomoto-Iwamoto M. Loss of ß-catenin induces multifocal periosteal chondroma-like masses in mice. Am J Pathol. 2013 Mar; 182(3):917-27. PMID: 23274133; PMCID: PMC3594871.
    55. Bush KT, Crawford BE, Garner OB, Nigam KB, Esko J, Nigam SK. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 07; 287(50):42064-70. PMID: 23060443; PMCID: PMC3516752.
    56. Lamanna WC, Lawrence R, Sarrazin S, Lameda-Diaz C, Gordts PL, Moremen KW, Esko J. A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 2012 Oct 19; 287(43):36283-90. PMID: 22952226; PMCID: PMC3476295.
    57. Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko J. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012 Aug 23; 120(8):1742-51. PMID: 22791291; PMCID: PMC3429312.
    58. Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko J, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. J Biol Chem. 2012 Aug 17; 287(34):28898-916. PMID: 22692203; PMCID: PMC3436526.
    59. Kowalewski B, Lamanna WC, Lawrence R, Damme M, Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D'Hooge R, Esko J, Dierks T. Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10310-5. PMID: 22689975; PMCID: PMC3387061.
    60. Le Jan S, Hayashi M, Kasza Z, Eriksson I, Bishop JR, Weibrecht I, Heldin J, Holmborn K, Jakobsson L, Söderberg O, Spillmann D, Esko J, Claesson-Welsh L, Kjellén L, Kreuger J. Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1255-63. PMID: 22345168; PMCID: PMC3331918.
    61. Baik JY, Gasimli L, Yang B, Datta P, Zhang F, Glass CA, Esko J, Linhardt RJ, Sharfstein ST. Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metab Eng. 2012 Mar; 14(2):81-90. PMID: 22326251; PMCID: PMC3299301.
    62. Lawrence R, Brown JR, Al-Mafraji K, Lamanna WC, Beitel JR, Boons GJ, Esko J, Crawford BE. Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat Chem Biol. 2012 Jan 08; 8(2):197-204. PMID: 22231271; PMCID: PMC3262053.
    63. Deng Y, Foley EM, Gonzales JC, Gordts PL, Li Y, Esko J. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology. 2012 Jan; 55(1):277-86. PMID: 21898481; PMCID: PMC3245353.
    64. Xu D, Young J, Song D, Esko J. Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J Biol Chem. 2011 Dec 02; 286(48):41736-44. PMID: 21990362; PMCID: PMC3308882.
    65. Kowalska MA, Krishnaswamy S, Rauova L, Zhai L, Hayes V, Amirikian K, Esko J, Bougie DW, Aster RH, Cines DB, Poncz M. Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood. 2011 Sep 08; 118(10):2882-8. PMID: 21772054; PMCID: PMC3172804.
    66. Zhao W, Garron ML, Yang B, Xiao Z, Esko J, Cygler M, Linhardt RJ. Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfoglucosamine residue. FEBS Lett. 2011 Aug 04; 585(15):2461-6. PMID: 21741976; PMCID: PMC3338322.
    67. Sarrazin S, Lamanna WC, Esko J. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 01; 3(7). PMID: 21690215; PMCID: PMC3119907.
    68. Chang YC, Wang Z, Flax LA, Xu D, Esko J, Nizet V, Baron MJ. Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog. 2011 Jun; 7(6):e1002082. PMID: 21731486; PMCID: PMC3121876.
    69. Zaiss AK, Lawrence R, Elashoff D, Esko J, Herschman HR. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. J Biol Chem. 2011 Jul 15; 286(28):24535-43. PMID: 21596747; PMCID: PMC3137028.
    70. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko J, Nigam SK. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 01; 356(1):19-27. PMID: 21600196; PMCID: PMC3130836.
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