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Jeffrey Esko

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0687
La Jolla CA 92093
Phone8/8-22--1100
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    Collapse Biography 
    Collapse Awards and Honors
    NIH1999  - 2009MERIT award
    Society for Glycobiology2007Karl Meyer Award
    Uppsala University2010Doctor of Medicine (honoris causa)
    International Glycoconjugate Organization2011IGO award
    American Association for the Advancement of Science2012Elected Fellow
    NIH2013Director's WALS Lecture

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Glycosylation of the perineuronal net in Alzheimer's Disease
    NIH/NIA R56AG062232Sep 30, 2018 - Aug 31, 2019
    Role: Co-Principal Investigator
    UCSD Biomedical Scientist Career Development Program in Glycoscience
    NIH/NHLBI K12HL141956Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Enhancement of wound healing and regeneration through heparan sulfate deficiency
    NIH/NIAMS R33AR073031Sep 1, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Enhancement of wound healing and regeneration through heparan sulfate deficiency
    NIH/NIAMS R61AR073031Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis
    NIH P01HL131474Jul 15, 2016 - Apr 30, 2021
    Role: Co-Investigator
    5th International MHE Research Conference
    NIH/NIAMS R13AR069987Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator
    Genome-wide Analysis of Heparan Sulfate using CRISPR/Cas9
    NIH/NCI R21CA199292Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Drug Discovery for Multiple Hereditary Exostoses
    NIH/NIAMS R01AR064202Sep 16, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Glycan Modulation of Inflammatory Responses
    NIH P01HL107150Jul 1, 2011 - May 31, 2018
    Role: Co-Investigator
    Structure and Function of 3-O-sulfation in Heparan Sulfate
    NIH/NIGMS R01GM093131May 1, 2010 - Apr 30, 2014
    Role: Principal Investigator
    Gene Discovery and Heparan Sulfate Biogenesis
    NIH/NHLBI R21HL098910Mar 1, 2010 - Dec 31, 2012
    Role: Principal Investigator
    GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    NIH/NIGMS R37GM033063Feb 5, 2010 - Nov 30, 2010
    Role: Principal Investigator
    Genetic Modulation of Blood and Vascular Glycosylation
    NIH/NHLBI P01HL057345Jun 8, 2009 - Oct 31, 2009
    Role: Co-Investigator
    Shared Instrumentation Grant: LTQ Linear Ion Trap Mass Spectrometer
    NIH/NCRR S10RR025507May 1, 2009 - Apr 30, 2010
    Role: Principal Investigator
    Altered endothelial heparan sulfate causes diaphragmatic hernias resembling CDH
    NIH/NICHD R21HD052920May 1, 2006 - Apr 30, 2009
    Role: Principal Investigator
    Glycoside Inhibitors of Tumor Metastasis
    NIH/NCI R01CA112278Feb 9, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Heparan Sulfate--a Novel Target for Cancer Therapeutics
    NIH/NCI U01CA091290Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    GORDON CONFERENCE--PROTEOGLYCANS
    NIH/NIAMS R13AR045230Jul 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    GLYCOSIDE ANTAGONISTS OF GLYCOSYLATION
    NIH/NCI R01CA046462Apr 20, 1990 - Mar 31, 1996
    Role: Principal Investigator
    Genetic analysis of proteoglycan-mediated lipoprotein clearance
    NIH/NIGMS R01GM033063Jul 1, 1983 - Nov 30, 1999
    Role: Principal Investigator
    SCOR IN ACUTE LUNG INJURY
    NIH/NHLBI P50HL023584Dec 1, 1978 - Nov 30, 2003
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate. Biochem J. 2020 Aug 28. Trabszo C, Ramms B, Chopra P, Lüllmann-Rauch R, Stroobants S, Sproß J, Jeschke A, Schinke T, Boons GJ, Esko J, Lübke T, Dierks T. PMID: 32856704.
      View in: PubMed   Mentions:    Fields:    
    2. Corrigendum to: Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants. Glycobiology. 2020 Aug 20; 30(9):760. Anower-E-Khuda F, Singh G, Deng Y, Gordts PLSM, Esko JD. PMID: 32091093.
      View in: PubMed   Mentions:    Fields:    
    3. Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity. bioRxiv. 2020 Aug 18. Martino C, Kellman BP, Sandoval DR, Clausen TM, Marotz CA, Song SJ, Wandro S, Zaramela LS, Salido Benítez RA, Zhu Q, Armingol E, Vázquez-Baeza Y, McDonald D, Sorrentino JT, Taylor B, Belda-Ferre P, Liang C, Zhang Y, Schifanella L, Klatt NR, Havulinna AS, Jousilahti P, Huang S, Haiminen N, Parida L, Kim HC, Swafford AD, Zengler K, Cheng S, Inouye M, Niiranen T, Jain M, Salomaa V, Esko JD, Lewis NE, Knight R. PMID: 32839779.
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    4. Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2020 Jul 24; 295(30):10508. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. PMID: 32709762.
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    5. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. bioRxiv. 2020 Jul 14. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32699853.
      View in: PubMed   Mentions:
    6. Beware, commercial chondroitinases vary in activity and substrate specificity. Glycobiology. 2020 Jun 23. Spliid CB, Toledo AG, Salanti A, Esko JD, Clausen TM. PMID: 32573715.
      View in: PubMed   Mentions:    Fields:    
    7. Author Correction: Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase. Sci Rep. 2020 Jun 09; 10(1):9586. Thieker DF, Xu Y, Chapla D, Nora C, Qiu H, Felix T, Wang L, Moremen KW, Liu J, Esko JD, Woods RJ. PMID: 32514069.
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    8. Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiol Dis. 2020 Aug; 142:104955. Callender JA, Sevillano AM, Soldau K, Kurt TD, Schumann T, Pizzo DP, Altmeppen H, Glatzel M, Esko JD, Sigurdson CJ. PMID: 32454127.
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    9. An Affinity-Chromatography and Glycoproteomics Workflow to Profile the Chondroitin Sulfate Proteoglycans that interact with malarial VAR2CSA in the Placenta and in Cancer. Glycobiology. 2020 Apr 27. Toledo AG, Pihl J, Spliid CB, Persson A, Nilsson J, Pereira MA, Gustavsson T, Choudhary S, Oo HZ, Black PC, Daugaard M, Esko JD, Larson G, Salanti A, Clausen TM. PMID: 32337544.
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    10. An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis. Osteoarthritis Cartilage. 2020 07; 28(7):977-987. Severmann AC, Jochmann K, Feller K, Bachvarova V, Piombo V, Stange R, Holzer T, Brachvogel B, Esko J, Pap T, Hoffmann D, Vortkamp A. PMID: 32315715.
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    11. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9311-9317. Weiss RJ, Spahn PN, Toledo AG, Chiang AWT, Kellman BP, Li J, Benner C, Glass CK, Gordts PLSM, Lewis NE, Esko JD. PMID: 32277030.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Mar 20. Bachvarova V, Dierker T, Esko J, Hoffmann D, Kjellen L, Vortkamp A. PMID: 32201365.
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    13. Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2020 Mar 13; 295(11):3747. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. PMID: 32169857.
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    14. Corrigendum to "The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis" [Matrix Biol. 71-72 (2018) 262-282]. Matrix Biol. 2020 06; 88:89. Gordts PLSM, Esko JD. PMID: 32144003.
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    15. Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. J Clin Invest. 2020 Mar 02; 130(3):1350-1362. Sevillano AM, Aguilar-Calvo P, Kurt TD, Lawrence JA, Soldau K, Nam TH, Schumann T, Pizzo DP, Nyström S, Choudhury B, Altmeppen H, Esko JD, Glatzel M, Nilsson KPR, Sigurdson CJ. PMID: 31985492.
      View in: PubMed   Mentions: 2     Fields:    
    16. Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein. J Biol Chem. 2020 Feb 28; 295(9):2804-2821. Sandoval DR, Gomez Toledo A, Painter CD, Tota EM, Sheikh MO, West AMV, Frank MM, Wells L, Xu D, Bicknell R, Corbett KD, Esko JD. PMID: 31964714.
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    17. Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions. Acta Neuropathol. 2020 03; 139(3):527-546. Aguilar-Calvo P, Sevillano AM, Bapat J, Soldau K, Sandoval DR, Altmeppen HC, Linsenmeier L, Pizzo DP, Geschwind MD, Sanchez H, Appleby BS, Cohen ML, Safar JG, Edland SD, Glatzel M, Nilsson KPR, Esko JD, Sigurdson CJ. PMID: 31673874.
      View in: PubMed   Mentions: 1     Fields:    
    18. Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis. Nat Commun. 2019 10 11; 10(1):4656. Toledo AG, Golden G, Campos AR, Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW, Esko JD. PMID: 31604940.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors. Arterioscler Thromb Vasc Biol. 2019 10; 39(10):2145-2156. Kegulian NC, Ramms B, Horton S, Trenchevska O, Nedelkov D, Graham MJ, Lee RG, Esko JD, Yassine HN, Gordts PLSM. PMID: 31390883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    20. Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants. Glycobiology. 2019 07 19; 29(8):582-592. Anower-E-Khuda F, Singh G, Deng Y, Gordts PLSM, Esko JD. PMID: 31094413.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2019 09 06; 294(36):13292-13303. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. PMID: 31315930.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. J Lipid Res. 2019 08; 60(8):1379-1395. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. PMID: 31092690.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    23. Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network. Proteomics. 2019 03; 19(5):e1800389. Pimienta G, Heithoff DM, Rosa-Campos A, Tran M, Esko JD, Mahan MJ, Marth JD, Smith JW. PMID: 30706660.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    24. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods. 2018 11; 15(11):889-899. Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L. PMID: 30377379.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase. Sci Rep. 2018 08 07; 8(1):11832. Thieker DF, Xu Y, Chapla D, Nora C, Qiu H, Felix T, Wang L, Moremen KW, Liu J, Esko JD, Woods RJ. PMID: 30087361.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    26. The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biol. 2018 10; 71-72:262-282. Gordts PLSM, Esko JD. PMID: 29803939.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes. Exp Lung Res. 2018 03; 44(2):98-112. Ge XN, Bastan I, Ha SG, Greenberg YG, Esko JD, Rao SP, Sriramarao P. PMID: 29621420.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    28. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. 2018; 7:6. Alavi Naini SM, Yanicostas C, Hassan-Abdi R, Blondeel S, Bennis M, Weiss RJ, Tor Y, Esko JD, Soussi-Yanicostas N. PMID: 29568517.
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    29. PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens. Sci Rep. 2017 Nov 20; 7(1):15854. Spahn PN, Bath T, Weiss RJ, Kim J, Esko JD, Lewis NE, Harismendy O. PMID: 29158538.
      View in: PubMed   Mentions: 3     Fields:    
    30. Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference. Connect Tissue Res. 2018 01; 59(1):85-98. Phan AQ, Pacifici M, Esko JD. PMID: 29099240.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. Cellular uptake of modified aminoglycosides. J Antibiot (Tokyo). 2017 Nov 01. Hadidi K, Wexselblatt E, Esko JD, Tor Y. PMID: 29089598.
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    32. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. 2017 08 21; 7(1):9008. Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E. PMID: 28827536.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    33. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. PMID: 28958576.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 2017 Jul 21; 15(27):5656-5668. Weiss RJ, Esko JD, Tor Y. PMID: 28653068.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    35. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017 04 18; 7:46576. Dwyer CA, Scudder SL, Lin Y, Dozier LE, Phan D, Allen NJ, Patrick GN, Esko JD. PMID: 28418018.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    36. Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chem Biol. 2017 02 17; 12(2):367-373. Dhamale OP, Lawrence R, Wiegmann EM, Shah BA, Al-Mafraji K, Lamanna WC, Lübke T, Dierks T, Boons GJ, Esko JD. PMID: 28055182.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    37. Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin a2 as a Host Factor for Bacterial Invasion. mBio. 2017 01 10; 8(1). van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. PMID: 28074024.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Delivery of Cargo to Lysosomes Using GNeosomes. Methods Mol Biol. 2017; 1594:151-163. Hamill KM, Wexselblatt E, Tong W, Esko JD, Tor Y. PMID: 28456981.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    39. Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules. Chembiochem. 2017 Jan 03; 18(1):119-125. Sganappa A, Wexselblatt E, Bellucci MC, Esko JD, Tedeschi G, Tor Y, Volonterio A. PMID: 27806190.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Delivery of an active lysosomal enzyme using GNeosomes. J Mater Chem B. 2016 Sep 21; 4(35):5794-5797. Hamill KM, Wexselblatt E, Tong W, Esko JD, Tor Y. PMID: 32263750.
      View in: PubMed   Mentions:    Fields:    
    41. Glycan susceptibility factors in autism spectrum disorders. Mol Aspects Med. 2016 10; 51:104-14. Dwyer CA, Esko JD. PMID: 27418189.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 08 01; 126(8):2855-66. Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD. PMID: 27400128.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    43. Polymyxins Facilitate Entry into Mammalian Cells. Chem Sci. 2016 Aug 01; 7(8):5059-5068. Hamill KM, McCoy LS, Wexselblatt E, Esko JD, Tor Y. PMID: 28044098.
      View in: PubMed   Mentions:
    44. Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. PLoS One. 2016; 11(3):e0150850. Khalid O, Vera MU, Gordts PL, Ellinwood NM, Schwartz PH, Dickson PI, Esko JD, Wang RY. PMID: 26986213.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    45. Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity. ACS Chem Biol. 2016 Apr 15; 11(4):971-80. Thacker BE, Seamen E, Lawrence R, Parker MW, Xu Y, Liu J, Vander Kooi CW, Esko JD. PMID: 26731579.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    46. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 2015 Dec; 25(12):1323-4. Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko JD, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi CR, Etzler ME, Frank M, Vliegenthart JF, Lütteke T, Perez S, Bolton E, Rudd P, Paulson J, Kanehisa M, Toukach P, Aoki-Kinoshita KF, Dell A, Narimatsu H, York W, Taniguchi N, Kornfeld S. PMID: 26543186.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    47. Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo. J Virol. 2016 01 01; 90(1):412-20. Zaiss AK, Foley EM, Lawrence R, Schneider LS, Hoveida H, Secrest P, Catapang AB, Yamaguchi Y, Alemany R, Shayakhmetov DM, Esko JD, Herschman HR. PMID: 26491162.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    48. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. Weiss RJ, Gordts PL, Le D, Xu D, Esko JD, Tor Y. PMID: 28133533.
      View in: PubMed   Mentions:
    49. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. PMID: 26150541.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    50. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. PMID: 25995222.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. Role of the endothelial surface layer in neutrophil recruitment. J Leukoc Biol. 2015 Oct; 98(4):503-15. Marki A, Esko JD, Pries AR, Ley K. PMID: 25979432.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    52. Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci. 2015 May; 56(5):3004-14. Coulson-Thomas VJ, Chang SH, Yeh LK, Coulson-Thomas YM, Yamaguchi Y, Esko J, Liu CY, Kao W. PMID: 26024086.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    53. GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery. ACS Nano. 2015; 9(4):3961-8. Wexselblatt E, Esko JD, Tor Y. PMID: 25831231.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015 May; 47(5):528-34. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagiroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. PMID: 25848753.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    55. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10; 6:6356. Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. PMID: 25754609.
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    56. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res. 2015 Mar; 56(3):665-73. Mooij HL, Bernelot Moens SJ, Gordts PL, Stanford KI, Foley EM, van den Boogert MA, Witjes JJ, Hassing HC, Tanck MW, van de Sande MA, Levels JH, Kastelein JJ, Stroes ES, Dallinga-Thie GM, Esko JD, Nieuwdorp M. PMID: 25568062.
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    57. Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-ß. Cytokine. 2015 Mar; 72(1):118-9. Gordts PL, Esko JD. PMID: 25573804.
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    58. Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume. PLoS One. 2014; 9(12):e115662. Bernelot Moens SJ, Mooij HL, Hassing HC, Kruit JK, Witjes JJ, van de Sande MA, Nederveen AJ, Xu D, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M. PMID: 25541963.
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    59. Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc. 2014 Dec 02; 3(6):e001274. Mooij HL, Cabrales P, Bernelot Moens SJ, Xu D, Udayappan SD, Tsai AG, van der Sande MA, de Groot E, Intaglietta M, Kastelein JJ, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M. PMID: 25468659.
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    60. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. PMID: 25440058.
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    61. Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15723-8. Wen J, Xiao J, Rahdar M, Choudhury BP, Cui J, Taylor GS, Esko JD, Dixon JE. PMID: 25331875.
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    62. Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem. 2014 Sep 05; 289(36):25211-26. Coulson-Thomas VJ, Gesteira TF, Esko J, Kao W. PMID: 25053416.
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    63. On guanidinium and cellular uptake. J Org Chem. 2014 Aug 01; 79(15):6766-74. Wexselblatt E, Esko JD, Tor Y. PMID: 25019333.
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    64. Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I. Mol Genet Metab. 2014 Aug; 112(4):286-93. Wang RY, Aminian A, McEntee MF, Kan SH, Simonaro CM, Lamanna WC, Lawrence R, Ellinwood NM, Guerra C, Le SQ, Dickson PI, Esko JD. PMID: 24951454.
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    65. Endothelial and leukocyte heparan sulfates regulate the development of allergen-induced airway remodeling in a mouse model. Glycobiology. 2014 Aug; 24(8):715-27. Ge XN, Ha SG, Rao A, Greenberg YG, Rushdi MN, Esko JD, Rao SP, Sriramarao P. PMID: 24794009.
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    66. Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney Int. 2014 Nov; 86(5):932-42. Rops AL, Loeven MA, van Gemst JJ, Eversen I, Van Wijk XM, Dijkman HB, van Kuppevelt TH, Berden JH, Rabelink TJ, Esko JD, van der Vlag J. PMID: 24759151.
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    67. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. PMID: 24726386.
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    68. Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters. Chembiochem. 2014 Mar 21; 15(5):676-80. Inoue M, Wexselblatt E, Esko JD, Tor Y. PMID: 24677320.
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    69. Demystifying heparan sulfate-protein interactions. Annu Rev Biochem. 2014; 83:129-57. Xu D, Esko JD. PMID: 24606135.
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    70. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan; 124(1):209-21. Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li D, Linhardt RJ, Esko JD, Wang L. PMID: 24355925.
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    71. Heparan sulfate 3-O-sulfation: a rare modification in search of a function. Matrix Biol. 2014 Apr; 35:60-72. Thacker BE, Xu D, Lawrence R, Esko JD. PMID: 24361527.
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    72. Bioengineering murine mastocytoma cells to produce anticoagulant heparin. Glycobiology. 2014 Mar; 24(3):272-80. Gasimli L, Glass CA, Datta P, Yang B, Li G, Gemmill TR, Baik JY, Sharfstein ST, Esko JD, Linhardt RJ. PMID: 24326668.
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    73. Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis. Matrix Biol. 2014 Apr; 35:253-65. Pan Y, Carbe C, Kupich S, Pickhinke U, Ohlig S, Frye M, Seelige R, Pallerla SR, Moon AM, Lawrence R, Esko JD, Zhang X, Grobe K. PMID: 24200809.
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    74. Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo. Kidney Int. 2014 Feb; 85(2):307-18. Sugar T, Wassenhove-McCarthy DJ, Esko JD, van Kuppevelt TH, Holzman L, McCarthy KJ. PMID: 23924956.
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    75. Glycan-based biomarkers for mucopolysaccharidoses. Mol Genet Metab. 2014 Feb; 111(2):73-83. Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko JD. PMID: 23958290.
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    76. Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2065-74. Foley EM, Gordts PLSM, Stanford KI, Gonzales JC, Lawrence R, Stoddard N, Esko JD. PMID: 23846497.
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    77. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013 Jul 19; 8(7):1611-20. Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD. PMID: 23679870.
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    78. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest. 2013 Jun; 123(6):2742-51. Gonzales JC, Gordts PL, Foley EM, Esko JD. PMID: 23676495.
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    79. Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol. 2013 Jul 19; 8(7):1383-8. Inoue M, Tong W, Esko JD, Tor Y. PMID: 23621420.
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    80. WITHDRAWN: Glycan-based biomarkers for mucopolysaccharidoses. Dis Markers. 2013 Feb 08. Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko JD. PMID: 23396297.
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    81. Loss of ß-catenin induces multifocal periosteal chondroma-like masses in mice. Am J Pathol. 2013 Mar; 182(3):917-27. Cantley L, Saunders C, Guttenberg M, Candela ME, Ohta Y, Yasuhara R, Kondo N, Sgariglia F, Asai S, Zhang X, Qin L, Hecht JT, Chen D, Yamamoto M, Toyosawa S, Dormans JP, Esko JD, Yamaguchi Y, Iwamoto M, Pacifici M, Enomoto-Iwamoto M. PMID: 23274133.
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    82. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 07; 287(50):42064-70. Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. PMID: 23060443.
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    83. A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 2012 Oct 19; 287(43):36283-90. Lamanna WC, Lawrence R, Sarrazin S, Lameda-Diaz C, Gordts PL, Moremen KW, Esko JD. PMID: 22952226.
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    84. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012 Aug 23; 120(8):1742-51. Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD. PMID: 22791291.
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    85. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. J Biol Chem. 2012 Aug 17; 287(34):28898-916. Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A. PMID: 22692203.
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    86. Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10310-5. Kowalewski B, Lamanna WC, Lawrence R, Damme M, Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D'Hooge R, Esko JD, Dierks T. PMID: 22689975.
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    87. Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1255-63. Le Jan S, Hayashi M, Kasza Z, Eriksson I, Bishop JR, Weibrecht I, Heldin J, Holmborn K, Jakobsson L, Söderberg O, Spillmann D, Esko JD, Claesson-Welsh L, Kjellén L, Kreuger J. PMID: 22345168.
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    88. Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metab Eng. 2012 Mar; 14(2):81-90. Baik JY, Gasimli L, Yang B, Datta P, Zhang F, Glass CA, Esko JD, Linhardt RJ, Sharfstein ST. PMID: 22326251.
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    89. Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat Chem Biol. 2012 Jan 08; 8(2):197-204. Lawrence R, Brown JR, Al-Mafraji K, Lamanna WC, Beitel JR, Boons GJ, Esko JD, Crawford BE. PMID: 22231271.
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    90. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology. 2012 Jan; 55(1):277-86. Deng Y, Foley EM, Gonzales JC, Gordts PL, Li Y, Esko JD. PMID: 21898481.
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    91. Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J Biol Chem. 2011 Dec 02; 286(48):41736-44. Xu D, Young J, Song D, Esko JD. PMID: 21990362.
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    92. Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood. 2011 Sep 08; 118(10):2882-8. Kowalska MA, Krishnaswamy S, Rauova L, Zhai L, Hayes V, Amirikian K, Esko JD, Bougie DW, Aster RH, Cines DB, Poncz M. PMID: 21772054.
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    93. Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfoglucosamine residue. FEBS Lett. 2011 Aug 04; 585(15):2461-6. Zhao W, Garron ML, Yang B, Xiao Z, Esko JD, Cygler M, Linhardt RJ. PMID: 21741976.
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    94. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 01; 3(7). Sarrazin S, Lamanna WC, Esko JD. PMID: 21690215.
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    95. Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog. 2011 Jun; 7(6):e1002082. Chang YC, Wang Z, Flax LA, Xu D, Esko JD, Nizet V, Baron MJ. PMID: 21731486.
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    96. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. J Biol Chem. 2011 Jul 15; 286(28):24535-43. Zaiss AK, Lawrence R, Elashoff D, Esko JD, Herschman HR. PMID: 21596747.
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    97. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 01; 356(1):19-27. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko JD, Nigam SK. PMID: 21600196.
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    98. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011 Jul 15; 355(2):394-403. Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. PMID: 21586278.
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    99. Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem. 2011 Apr 22; 286(16):14435-44. Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X. PMID: 21357686.
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    100. Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones. Bone. 2011 May 01; 48(5):979-87. Zak BM, Schuksz M, Koyama E, Mundy C, Wells DE, Yamaguchi Y, Pacifici M, Esko JD. PMID: 21310272.
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    101. Secondary storage of dermatan sulfate in Sanfilippo disease. J Biol Chem. 2011 Mar 04; 286(9):6955-62. Lamanna WC, Lawrence R, Sarrazin S, Esko JD. PMID: 21193389.
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    102. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919. Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. PMID: 21085708.
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    103. Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides. Chembiochem. 2010 Nov 02; 11(16):2302-10. Dix AV, Fischer L, Sarrazin S, Redgate CP, Esko JD, Tor Y. PMID: 20931643.
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    104. Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability. J Biol Chem. 2011 Jan 07; 286(1):737-45. Xu D, Fuster MM, Lawrence R, Esko JD. PMID: 20974861.
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    105. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One. 2010 May 18; 5(5):e10691. Crawford BE, Garner OB, Bishop JR, Zhang DY, Bush KT, Nigam SK, Esko JD. PMID: 20502530.
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    106. Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection. PLoS One. 2010 May 06; 5(5):e10510. Dai E, Liu LY, Wang H, McIvor D, Sun YM, Macaulay C, King E, Munuswamy-Ramanujam G, Bartee MY, Williams J, Davids J, Charo I, McFadden G, Esko JD, Lucas AR. PMID: 20463901.
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    107. Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes. Mol Ther. 2010 Jul; 18(7):1268-74. Sarrazin S, Wilson B, Sly WS, Tor Y, Esko JD. PMID: 20442709.
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    108. Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate. J Biol Chem. 2010 May 07; 285(19):14658-62. Bishop JR, Foley E, Lawrence R, Esko JD. PMID: 20236939.
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    109. Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling. J Mol Cell Cardiol. 2010 Aug; 49(2):287-93. Adhikari N, Basi DL, Townsend D, Rusch M, Mariash A, Mullegama S, Watson A, Larson J, Tan S, Lerman B, Esko JD, Selleck SB, Hall JL. PMID: 20206635.
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    110. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. J Biol Chem. 2011 Feb 18; 286(7):5338-46. Gesteira TF, Coulson-Thomas VJ, Taunay-Rodrigues A, Oliveira V, Thacker BE, Juliano MA, Pasqualini R, Arap W, Tersariol IL, Nader HB, Esko JD, Pinhal MA. PMID: 20129923.
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    111. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol. 2010 Mar 15; 339(2):354-65. Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush KT, Esko JD, Nigam SK. PMID: 20059993.
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    116. Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 05; 114(19):4300-9. Zhang B, Dietrich UM, Geng JG, Bicknell R, Esko JD, Wang L. PMID: 19741192.
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    118. Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation. J Immunol. 2009 Sep 15; 183(6):3971-9. Zuberi RI, Ge XN, Jiang S, Bahaie NS, Kang BN, Hosseinkhani RM, Frenzel EM, Fuster MM, Esko JD, Rao SP, Sriramarao P. PMID: 19710461.
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    119. A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol. 2009 07 31; 16(7):773-82. Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M. PMID: 19635414.
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    120. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem. 2009 Feb 20; 284(8):4952-9. Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK, Esko JD. PMID: 19106107.
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    121. Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif. J Am Soc Mass Spectrom. 2009 Apr; 20(4):652-7. Meissen JK, Sweeney MD, Girardi M, Lawrence R, Esko JD, Leary JA. PMID: 19185514.
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    122. Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem. 2009 Jan 23; 284(4):2576-83. Bakker H, Oka T, Ashikov A, Yadav A, Berger M, Rana NA, Bai X, Jigami Y, Haltiwanger RS, Esko JD, Gerardy-Schahn R. PMID: 19028698.
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    123. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem. 2008 Dec 12; 283(50):34511-8. Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. PMID: 18845532.
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    124. Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling. J Biol Chem. 2008 Nov 28; 283(48):33674-84. Lawrence R, Olson SK, Steele RE, Wang L, Warrior R, Cummings RD, Esko JD. PMID: 18818196.
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    125. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13075-80. Schuksz M, Fuster MM, Brown JR, Crawford BE, Ditto DP, Lawrence R, Glass CA, Wang L, Tor Y, Esko JD. PMID: 18725627.
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    126. Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology. 2008 Oct; 18(10):747-9. Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. PMID: 18621991.
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    127. Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism. Curr Opin Lipidol. 2008 Jun; 19(3):307-13. Bishop JR, Stanford KI, Esko JD. PMID: 18460924.
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    128. Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate. Immunology. 2008 Nov; 125(3):420-9. Garner OB, Yamaguchi Y, Esko JD, Videm V. PMID: 18479348.
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    129. Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem. 2008 Jun 13; 283(24):16885-94. Pallerla SR, Lawrence R, Lewejohann L, Pan Y, Fischer T, Schlomann U, Zhang X, Esko JD, Grobe K. PMID: 18385133.
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    130. Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans. Nat Methods. 2008 Apr; 5(4):291-2. Lawrence R, Lu H, Rosenberg RD, Esko JD, Zhang L. PMID: 18376390.
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    131. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest. 2008 Jan; 118(1):229-38. Bode L, Salvestrini C, Park PW, Li JP, Esko JD, Yamaguchi Y, Murch S, Freeze HH. PMID: 18064305.
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    132. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development. 2008 Jan; 135(2):301-10. Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X. PMID: 18077586.
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    133. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe. 2007 Nov 15; 2(5):316-27. Coppi A, Tewari R, Bishop JR, Bennett BL, Lawrence R, Esko JD, Billker O, Sinnis P. PMID: 18005753.
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    134. Glycan antagonists and inhibitors: a fount for drug discovery. Crit Rev Biochem Mol Biol. 2007 Nov-Dec; 42(6):481-515. Brown JR, Crawford BE, Esko JD. PMID: 18066955.
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    135. Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis. J Cell Biol. 2007 May 07; 177(3):539-49. Fuster MM, Wang L, Castagnola J, Sikora L, Reddi K, Lee PH, Radek KA, Schuksz M, Bishop JR, Gallo RL, Sriramarao P, Esko JD. PMID: 17470635.
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    136. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature. 2007 Apr 26; 446(7139):1030-7. Bishop JR, Schuksz M, Esko JD. PMID: 17460664.
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    137. Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Stem Cells. 2007 Aug; 25(8):1913-23. Johnson CE, Crawford BE, Stavridis M, Ten Dam G, Wat AL, Rushton G, Ward CM, Wilson V, van Kuppevelt TH, Esko JD, Smith A, Gallagher JT, Merry CL. PMID: 17464092.
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    138. Selectin blocking activity of a fucosylated chondroitin sulfate glycosaminoglycan from sea cucumber. Effect on tumor metastasis and neutrophil recruitment. J Biol Chem. 2007 May 18; 282(20):14984-91. Borsig L, Wang L, Cavalcante MC, Cardilo-Reis L, Ferreira PL, Mourão PA, Esko JD, Pavão MS. PMID: 17371880.
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    139. Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway. J Biol Chem. 2007 May 04; 282(18):13585-91. Elson-Schwab L, Garner OB, Schuksz M, Crawford BE, Esko JD, Tor Y. PMID: 17311923.
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    140. Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Dev Dyn. 2007 Feb; 236(2):556-63. Pallerla SR, Pan Y, Zhang X, Esko JD, Grobe K. PMID: 17183530.
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    141. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest. 2007 Jan; 117(1):153-64. MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum JL, Esko JD. PMID: 17200715.
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    142. Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans. J Biol Chem. 2007 Feb 23; 282(8):5201-6. Pönighaus C, Ambrosius M, Casanova JC, Prante C, Kuhn J, Esko JD, Kleesiek K, Götting C. PMID: 17189265.
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    143. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006 Dec; 133(24):4933-44. Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X. PMID: 17107998.
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    144. Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. J Cell Biol. 2006 Jun 19; 173(6):985-94. Olson SK, Bishop JR, Yates JR, Oegema K, Esko JD. PMID: 16785326.
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    145. A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination. Clin Cancer Res. 2006 May 01; 12(9):2894-901. Brown JR, Fuster MM, Li R, Varki N, Glass CA, Esko JD. PMID: 16675586.
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    146. The morphogenic properties of oligomeric endostatin are dependent on cell surface heparan sulfate. J Biol Chem. 2006 May 26; 281(21):14813-22. Clamp A, Blackhall FH, Henrioud A, Jayson GC, Javaherian K, Esko J, Gallagher JT, Merry CL. PMID: 16481316.
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    147. CHO glycosylation mutants: proteoglycans. Methods Enzymol. 2006; 416:205-21. Zhang L, Lawrence R, Frazier BA, Esko JD. PMID: 17113868.
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    148. Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to L-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase. Bioorg Med Chem Lett. 2006 Feb; 16(3):532-6. Brown JR, Nishimura Y, Esko JD. PMID: 16275065.
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    149. Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 2005 Nov; 132(22):5055-68. Stickens D, Zak BM, Rougier N, Esko JD, Werb Z. PMID: 16236767.
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    150. A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology. 2006 Feb; 16(2):117-31. Comelli EM, Head SR, Gilmartin T, Whisenant T, Haslam SM, North SJ, Wong NK, Kudo T, Narimatsu H, Esko JD, Drickamer K, Dell A, Paulson JC. PMID: 16237199.
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    151. Cell surface heparan sulfate promotes replication of Toxoplasma gondii. Infect Immun. 2005 Sep; 73(9):5395-401. Bishop JR, Crawford BE, Esko JD. PMID: 16113255.
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    152. Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol. 2005 Sep; 6(9):902-10. Wang L, Fuster M, Sriramarao P, Esko JD. PMID: 16056228.
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    153. Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties. J Am Chem Soc. 2005 Jul 27; 127(29):10132-3. Rele SM, Cui W, Wang L, Hou S, Barr-Zarse G, Tatton D, Gnanou Y, Esko JD, Chaikof EL. PMID: 16028900.
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    154. Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function. Development. 2005 Aug; 132(16):3777-86. Grobe K, Inatani M, Pallerla SR, Castagnola J, Yamaguchi Y, Esko JD. PMID: 16020517.
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    155. The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer. 2005 Jul; 5(7):526-42. Fuster MM, Esko JD. PMID: 16069816.
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    156. The elusive role of heparan sulfate in Toxoplasma gondii infection. Mol Biochem Parasitol. 2005 Feb; 139(2):267-9. Bishop JR, Esko JD. PMID: 15664661.
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    157. Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1507-12. Kinnunen T, Huang Z, Townsend J, Gatdula MM, Brown JR, Esko JD, Turnbull JE. PMID: 15671174.
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    158. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 2004 Nov; 6(5):485-95. Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. PMID: 15542432.
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    159. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004 Aug 15; 272(2):310-27. Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. PMID: 15282150.
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    160. Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity. J Cell Sci. 2004 Jul 01; 117(Pt 15):3331-41. Nagai N, Habuchi H, Esko JD, Kimata K. PMID: 15226404.
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    161. Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol. 2004 Jun; 78(12):6567-84. Bobardt MD, Salmon P, Wang L, Esko JD, Gabuzda D, Fiala M, Trono D, Van der Schueren B, David G, Gallay PA. PMID: 15163749.
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    162. Temperature-sensitive glycosaminoglycan biosynthesis in a Chinese hamster ovary cell mutant containing a point mutation in glucuronyltransferase I. J Biol Chem. 2004 Feb 13; 279(7):5693-8. Wei G, Bai X, Esko JD. PMID: 14623881.
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    163. Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expression. Chembiochem. 2003 Sep 05; 4(9):835-40. Mong TK, Lee LV, Brown JR, Esko JD, Wong CH. PMID: 12964157.
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    164. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. J Biol Chem. 2003 Nov 14; 278(46):45594-602. Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Müller R, Brown JR, Hennet T, Esko JD, Aroian RV. PMID: 12944392.
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    165. Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem. 2003 Oct 10; 278(41):40041-9. Ben-Zaken O, Tzaban S, Tal Y, Horonchik L, Esko JD, Vlodavsky I, Taraboulos A. PMID: 12871949.
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    166. A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells. Cancer Res. 2003 Jun 01; 63(11):2775-81. Fuster MM, Brown JR, Wang L, Esko JD. PMID: 12782582.
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    167. Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature. 2003 May 22; 423(6938):439-43. Hwang HY, Olson SK, Esko JD, Horvitz HR. PMID: 12761549.
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    168. Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys. J Biol Chem. 2003 Jun 27; 278(26):23352-9. Brown JR, Fuster MM, Whisenant T, Esko JD. PMID: 12686549.
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    169. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. J Biol Chem. 2003 Apr 04; 278(14):11735-8. Hwang HY, Olson SK, Brown JR, Esko JD, Horvitz HR. PMID: 12584198.
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    170. Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes. Biochim Biophys Acta. 2002 Dec 19; 1573(3):209-15. Grobe K, Ledin J, Ringvall M, Holmborn K, Forsberg E, Esko JD, Kjellén L. PMID: 12417402.
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    171. Hereditary multiple exostoses and heparan sulfate polymerization. Biochim Biophys Acta. 2002 Dec 19; 1573(3):346-55. Zak BM, Crawford BE, Esko JD. PMID: 12417417.
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    172. Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology. 2002 Nov; 12(11):721-7. Ford-Perriss M, Guimond SE, Greferath U, Kita M, Grobe K, Habuchi H, Kimata K, Esko JD, Murphy M, Turnbull JE. PMID: 12460940.
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    173. A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment. Int Immunol. 2002 Sep; 14(9):1039-53. Mertsching E, Wurster AL, Katayama C, Esko J, Ramsdell F, Marth JD, Hedrick SM. PMID: 12202401.
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    174. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest. 2002 Jul; 110(1):127-36. Wang L, Brown JR, Varki A, Esko JD. PMID: 12093896.
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    175. Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites. J Biol Chem. 2002 Aug 23; 277(34):30699-706. Grobe K, Esko JD. PMID: 12070138.
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    176. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther. 2002 May; 5(5 Pt 1):538-46. Guibinga GH, Miyanohara A, Esko JD, Friedmann T. PMID: 11991744.
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    177. Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture. Glycobiology. 2002 May; 12(5):345-51. Yabushita H, Noguchi Y, Habuchi H, Ashikari S, Nakabe K, Fujita M, Noguchi M, Esko JD, Kimata K. PMID: 12070077.
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    178. Tumor attenuation by combined heparan sulfate and polyamine depletion. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):371-6. Belting M, Borsig L, Fuster MM, Brown JR, Persson L, Fransson LA, Esko JD. PMID: 11752393.
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    179. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem. 2002; 71:435-71. Esko JD, Selleck SB. PMID: 12045103.
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    180. Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):12984-9. Pinhal MA, Smith B, Olson S, Aikawa J, Kimata K, Esko JD. PMID: 11687650.
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    181. Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). J Biol Chem. 2001 Dec 21; 276(51):48189-95. Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD. PMID: 11551958.
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    182. Enhanced 3-O-sulfation of galactose in Asn-linked glycans and Maackia amurensis lectin binding in a new Chinese hamster ovary cell line. Glycobiology. 2001 Aug; 11(8):621-32. Bai X, Brown JR, Varki A, Esko JD. PMID: 11479273.
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    183. Molecular diversity of heparan sulfate. J Clin Invest. 2001 Jul; 108(2):169-73. Esko JD, Lindahl U. PMID: 11457867.
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    184. Etiological point mutations in the hereditary multiple exostoses gene EXT1: a functional analysis of heparan sulfate polymerase activity. Am J Hum Genet. 2001 Jul; 69(1):55-66. Cheung PK, McCormick C, Crawford BE, Esko JD, Tufaro F, Duncan G. PMID: 11391482.
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    185. The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate. J Biol Chem. 2001 Aug 03; 276(31):28806-13. Zhang L, Lawrence R, Schwartz JJ, Bai X, Wei G, Esko JD, Rosenberg RD. PMID: 11375390.
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    186. Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells. Blood. 2001 May 15; 97(10):3032-9. Morii E, Ogihara H, Oboki K, Sawa C, Sakuma T, Nomura S, Esko JD, Handa H, Kitamura Y. PMID: 11342428.
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    187. The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for plasmodium sporozoite attachment to target cells. J Biol Chem. 2001 Jul 20; 276(29):26784-91. Pinzon-Ortiz C, Friedman J, Esko J, Sinnis P. PMID: 11352923.
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    188. Synthetic glycosides as primers of oligosaccharide biosynthesis and inhibitors of glycoprotein and proteoglycan assembly. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.11. Esko JD, Montgomery RI. PMID: 18265139.
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    189. Special considerations for proteoglycans and glycosaminoglycans and their purification. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.2. Esko JD. PMID: 18265153.
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    190. Direct chemical analysis of glycoconjugates for carbohydrates. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.9. Manzi A, Esko J. PMID: 18265165.
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    191. Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase. J Biol Chem. 2001 Jun 15; 276(24):21538-43. Crawford BE, Olson SK, Esko JD, Pinhal MA. PMID: 11279150.
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    192. Selection of glycosaminoglycan-deficient mutants. Methods Mol Biol. 2001; 171:309-16. Bai X, Crawford B, Esko JD. PMID: 11450242.
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    193. Xyloside priming of glycosaminoglycan biosynthesis and inhibition of proteoglycan assembly. Methods Mol Biol. 2001; 171:317-23. Fritz TA, Esko JD. PMID: 11450243.
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    194. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. J Biol Chem. 2001 Feb 23; 276(8):5876-82. Aikawa J, Grobe K, Tsujimoto M, Esko JD. PMID: 11087757.
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    195. Synthesis and glycan priming activity of acetylated disaccharides. Carbohydr Res. 2000 Nov 03; 329(2):287-300. Sarkar AK, Brown JR, Esko JD. PMID: 11117312.
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    196. sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10838-43. Bulik DA, Wei G, Toyoda H, Kinoshita-Toyoda A, Waldrip WR, Esko JD, Robbins PW, Selleck SB. PMID: 11005858.
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    197. Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants. J Biol Chem. 2000 Sep 08; 275(36):27733-40. Wei G, Bai X, Gabb MM, Bame KJ, Koshy TI, Spear PG, Esko JD. PMID: 10864928.
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    198. Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15; 224(2):299-311. Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MM. PMID: 10926768.
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    199. Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans. Glycobiology. 2000 Jul; 10(7):691-700. Norgard-Sumnicht K, Bai X, Esko JD, Varki A, Manzi AE. PMID: 10910973.
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    200. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell. 1999 Oct 01; 99(1):13-22. Shukla D, Liu J, Blaiklock P, Shworak NW, Bai X, Esko JD, Cohen GH, Eisenberg RJ, Rosenberg RD, Spear PG. PMID: 10520990.
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    201. Glycoside primers of Psittacanthus cucullaris. J Nat Prod. 1999 Jul; 62(7):1036-8. Sinha A, Taylor WH, Khan IH, McDaniel ST, Esko JD. PMID: 10425137.
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    202. Chinese hamster ovary cell mutants defective in glycosaminoglycan assembly and glucuronosyltransferase I. J Biol Chem. 1999 May 07; 274(19):13017-24. Bai X, Wei G, Sinha A, Esko JD. PMID: 10224052.
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    203. Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:Galactose beta1, 3-glucuronosyltransferases. J Biol Chem. 1999 Mar 19; 274(12):7857-64. Wei G, Bai X, Sarkar AK, Esko JD. PMID: 10075678.
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    204. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. J Biol Chem. 1999 Jan 29; 274(5):2690-5. Aikawa J, Esko JD. PMID: 9915799.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    205. Primers of glycosaminoglycan biosynthesis from Peruvian rain forest plants. J Biol Chem. 1998 Aug 28; 273(35):22260-6. Taylor WH, Sinha A, Khan IA, McDaniel ST, Esko JD. PMID: 9712841.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    206. Fucosylation of disaccharide precursors of sialyl LewisX inhibit selectin-mediated cell adhesion. J Biol Chem. 1997 Oct 10; 272(41):25608-16. Sarkar AK, Rostand KS, Jain RK, Matta KL, Esko JD. PMID: 9325281.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    207. Turnover of heparan sulfate depends on 2-O-sulfation of uronic acids. J Biol Chem. 1997 Sep 12; 272(37):23172-9. Bai X, Bame KJ, Habuchi H, Kimata K, Esko JD. PMID: 9287321.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    208. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nat Med. 1997 Aug; 3(8):866-71. Chen Y, Maguire T, Hileman RE, Fromm JR, Esko JD, Linhardt RJ, Marks RM. PMID: 9256277.
      View in: PubMed   Mentions: 262     Fields:    Translation:AnimalsCells
    209. Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG. J Biol Chem. 1997 Aug 01; 272(31):19205-13. Gantt SM, Clavijo P, Bai X, Esko JD, Sinnis P. PMID: 9235912.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    210. Partial purification and substrate specificity of heparan sulfate alpha-N-acetylglucosaminyltransferase I: synthesis, NMR spectroscopic characterization and in vitro assays of two aryl tetrasaccharides. Glycobiology. 1997 Jul; 7(5):587-95. Fritz TA, Agrawal PK, Esko JD, Krishna NR. PMID: 9254041.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    211. Microbial adherence to and invasion through proteoglycans. Infect Immun. 1997 Jan; 65(1):1-8. Rostand KS, Esko JD. PMID: 8975885.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    212. Influence of core protein sequence on glycosaminoglycan assembly. Curr Opin Struct Biol. 1996 Oct; 6(5):663-70. Esko JD, Zhang L. PMID: 8913690.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    213. Unusual beta-D-xylosides that prime glycosaminoglycans in animal cells. J Biol Chem. 1996 Aug 09; 271(32):19159-65. Lugemwa FN, Sarkar AK, Esko JD. PMID: 8702593.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    214. An animal cell mutant defective in heparan sulfate hexuronic acid 2-O-sulfation. J Biol Chem. 1996 Jul 26; 271(30):17711-7. Bai X, Esko JD. PMID: 8663454.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    215. Synthesis and secretion of lipoprotein lipase in heparan sulfate-deficient Chinese hamster ovary cells. Isr J Med Sci. 1996 Jun; 32(6):430-44. Olivecrona G, Vilaró S, Esko JD, Olivecrona T. PMID: 8682648.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    216. Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):257-66. Frevert U, Sinnis P, Esko JD, Nussenzweig V. PMID: 8920011.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    217. Synthesis and glycosaminoglycan priming activity of three disaccharides related to the linkage region tetrasaccharide of proteoglycans. Carbohydr Res. 1995 Dec 27; 279:161-71. Sarkar AK, Esko JD. PMID: 8593621.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    218. Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans. J Biol Chem. 1995 Nov 10; 270(45):27127-35. Zhang L, David G, Esko JD. PMID: 7592967.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    219. Developmentally regulated sensitivity of Trypanosoma brucei brucei to the cytotoxic effects of human high-density lipoprotein. Exp Parasitol. 1995 Sep; 81(2):216-26. Moore DR, Smith A, Hager KM, Waldon R, Esko JD, Hajduk SL. PMID: 7556564.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    220. Accumulation of a pentasaccharide terminating in alpha-N-acetylglucosamine in an animal cell mutant defective in heparan sulfate biosynthesis. J Biol Chem. 1995 May 26; 270(21):12557-62. Zhang L, Esko JD. PMID: 7759502.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    221. Killing of trypanosomes by the human haptoglobin-related protein. Science. 1995 Apr 14; 268(5208):284-6. Smith AB, Esko JD, Hajduk SL. PMID: 7716520.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    222. Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1-->4GlcNAc beta-O-naphthalenemethanol. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3323-7. Sarkar AK, Fritz TA, Taylor WH, Esko JD. PMID: 7724561.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    223. Heparan sulfate primed on beta-D-xylosides restores binding of basic fibroblast growth factor. J Cell Biochem. 1995 Feb; 57(2):173-84. Miao HQ, Fritz TA, Esko JD, Zimmermann J, Yayon A, Vlodavsky I. PMID: 7759555.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    224. Reconstitution of the trypanolytic factor from components of a subspecies of human high-density lipoproteins. Mol Biochem Parasitol. 1995 Jan; 69(1):9-17. Tytler EM, Moore DR, Pierce MA, Hager KM, Esko JD, Hajduk SL. PMID: 7723792.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    225. Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate. J Biol Chem. 1994 Nov 18; 269(46):28809-14. Fritz TA, Gabb MM, Wei G, Esko JD. PMID: 7961837.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    226. Sulphated and undersulphated heparan sulphate proteoglycans in a Chinese hamster ovary cell mutant defective in N-sulphotransferase. Biochem J. 1994 Oct 01; 303 ( Pt 1):81-7. Bame KJ, Zhang L, David G, Esko JD. PMID: 7945269.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    227. Amino acid determinants that drive heparan sulfate assembly in a proteoglycan. J Biol Chem. 1994 Jul 29; 269(30):19295-9. Zhang L, Esko JD. PMID: 8034692.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    228. Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes. J Cell Biol. 1994 Jul; 126(1):155-67. Hager KM, Pierce MA, Moore DR, Tytler EM, Esko JD, Hajduk SL. PMID: 8027174.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    229. Biosynthesis of heparan sulfate on beta-D-xylosides depends on aglycone structure. J Biol Chem. 1994 Jan 07; 269(1):300-7. Fritz TA, Lugemwa FN, Sarkar AK, Esko JD. PMID: 8276811.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    230. Human high density lipoprotein killing of African trypanosomes. Annu Rev Microbiol. 1994; 48:139-62. Hajduk SL, Hager KM, Esko JD. PMID: 7826003.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    231. Thrombin adhesive properties: induction by plasmin and heparan sulfate. J Cell Biol. 1993 Dec; 123(5):1279-87. Bar-Shavit R, Eskohjido Y, Fenton JW, Esko JD, Vlodavsky I. PMID: 8245131.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    232. Cholesterol and cholesterol esters: host receptors for Pseudomonas aeruginosa adherence. J Biol Chem. 1993 Nov 15; 268(32):24053-9. Rostand KS, Esko JD. PMID: 8226950.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    233. A heparin-binding activity on Leishmania amastigotes which mediates adhesion to cellular proteoglycans. J Cell Biol. 1993 Nov; 123(3):759-66. Love DC, Esko JD, Mosser DM. PMID: 8227137.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    234. Synthesis of beta-estradiol beta-D-xylopyranosides, primers of heparan sulfate in Chinese hamster ovary cells. Carbohydr Res. 1993 Feb 01; 239:285-90. Lugemwa FN, Esko JD. PMID: 8457998.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    235. Stable heparin-producing cell lines derived from the Furth murine mastocytoma. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11327-31. Montgomery RI, Lidholt K, Flay NW, Liang J, Vertel B, Lindahl U, Esko JD. PMID: 1454815.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    236. Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate. Virology. 1992 Jul; 189(1):48-58. Neyts J, Snoeck R, Schols D, Balzarini J, Esko JD, Van Schepdael A, De Clercq E. PMID: 1376540.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    237. A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2267-71. Lidholt K, Weinke JL, Kiser CS, Lugemwa FN, Bame KJ, Cheifetz S, Massagué J, Lindahl U, Esko JD. PMID: 1532254.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    238. Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans. J Cell Biol. 1992 Mar; 116(5):1273-81. Shieh MT, WuDunn D, Montgomery RI, Esko JD, Spear PG. PMID: 1310996.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    239. High-density lipoprotein-mediated lysis of trypanosomes. Parasitol Today. 1992 Mar; 8(3):95-8. Hajduk SL, Hager K, Esko JD. PMID: 15463583.
      View in: PubMed   Mentions: 8     Fields:    
    240. Animal cell mutants defective in heparan sulfate polymerization. Adv Exp Med Biol. 1992; 313:97-106. Esko JD. PMID: 1442273.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    241. Genetic analysis of proteoglycan structure, function and metabolism. Curr Opin Cell Biol. 1991 Oct; 3(5):805-16. Esko JD. PMID: 1931081.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    242. Coupling of N-deacetylation and N-sulfation in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase. J Biol Chem. 1991 Jul 05; 266(19):12461-8. Bame KJ, Reddy RV, Esko JD. PMID: 2061321.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    243. Biosynthesis of heparan sulfate. Coordination of polymer-modification reactions in a Chinese hamster ovary cell mutant defective in N-sulfotransferase. J Biol Chem. 1991 Jun 05; 266(16):10287-93. Bame KJ, Lidholt K, Lindahl U, Esko JD. PMID: 2037581.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    244. Estradiol beta-D-xyloside, an efficient primer for heparan sulfate biosynthesis. J Biol Chem. 1991 Apr 15; 266(11):6674-7. Lugemwa FN, Esko JD. PMID: 2016281.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    245. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991 Feb 22; 64(4):841-8. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. PMID: 1847668.
      View in: PubMed   Mentions: 492     Fields:    Translation:AnimalsCells
    246. Secretory heparin in murine mastocytoma cell lines. Biochem Soc Trans. 1990 Oct; 18(5):807-9. Esko JD, Montgomery RI, Lindahl U. PMID: 2128061.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    247. Binding of heparan sulfate to type V collagen. A mechanism of cell-substrate adhesion. J Biol Chem. 1989 May 15; 264(14):7950-6. LeBaron RG, Höök A, Esko JD, Gay S, Höök M. PMID: 2524477.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    248. Undersulfated heparan sulfate in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase. J Biol Chem. 1989 May 15; 264(14):8059-65. Bame KJ, Esko JD. PMID: 2524478.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    249. Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein. J Biol Chem. 1989 Mar 25; 264(9):5210-7. Hajduk SL, Moore DR, Vasudevacharya J, Siqueira H, Torri AF, Tytler EM, Esko JD. PMID: 2494183.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    250. Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan. J Clin Invest. 1989 Mar; 83(3):994-1001. Kaesberg PR, Ershler WB, Esko JD, Mosher DF. PMID: 2522106.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    251. Replica plating of animal cells. Methods Cell Biol. 1989; 32:387-422. Esko JD. PMID: 2691858.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    252. Chinese hamster ovary cell mutants deficient in an anion exchanger functionally similar to the erythroid band 3. J Biol Chem. 1988 Dec 15; 263(35):18607-13. Elgavish A, Esko JD, Knurr A. PMID: 3198592.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    253. Tumor formation dependent on proteoglycan biosynthesis. Science. 1988 Aug 26; 241(4869):1092-6. Esko JD, Rostand KS, Weinke JL. PMID: 3137658.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    254. Altered metabolism of thrombospondin by Chinese hamster ovary cells defective in glycosaminoglycan synthesis. J Biol Chem. 1988 May 05; 263(13):6400-6. Murphy-Ullrich JE, Westrick LG, Esko JD, Mosher DF. PMID: 3129423.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    255. Adhesion of glycosaminoglycan-deficient chinese hamster ovary cell mutants to fibronectin substrata. J Cell Biol. 1988 Mar; 106(3):945-52. LeBaron RG, Esko JD, Woods A, Johansson S, Höök M. PMID: 3346331.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    256. Inhibition of chondroitin and heparan sulfate biosynthesis in Chinese hamster ovary cell mutants defective in galactosyltransferase I. J Biol Chem. 1987 Sep 05; 262(25):12189-95. Esko JD, Weinke JL, Taylor WH, Ekborg G, Rodén L, Anantharamaiah G, Gawish A. PMID: 2957376.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    257. Reaction of unsaturated uronic acid residues with mercuric salts. Cleavage of the hyaluronic acid disaccharide 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose. Biochem J. 1987 Aug 01; 245(3):795-804. Ludwigs U, Elgavish A, Esko JD, Meezan E, Rodén L. PMID: 3663191.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    258. Sulfate transport-deficient mutants of Chinese hamster ovary cells. Sulfation of glycosaminoglycans dependent on cysteine. J Biol Chem. 1986 Nov 25; 261(33):15725-33. Esko JD, Elgavish A, Prasthofer T, Taylor WH, Weinke JL. PMID: 3782085.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    259. Detection of animal cell LDL mutants by replica plating. Methods Enzymol. 1986; 129:237-53. Esko JD. PMID: 3523146.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    260. Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 1985 May; 82(10):3197-201. Esko JD, Stewart TE, Taylor WH. PMID: 3858816.
      View in: PubMed   Mentions: 233     Fields:    Translation:AnimalsCells
    261. Biosynthesis of phosphatidylcholine from serum phospholipids in Chinese hamster ovary cells deprived of choline. J Biol Chem. 1983 Mar 10; 258(5):3051-7. Esko JD, Matsuoka KY. PMID: 6826551.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    262. Autoradiographic detection and characterization of a Chinese hamster ovary cell mutant deficient in fucoproteins. J Cell Physiol. 1982 Jun; 111(3):255-63. Hirschberg CB, Perez M, Snider M, Hanneman WL, Esko J, Raetz CR. PMID: 6284769.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    263. Somatic cell cloning in polyester stacks. Proc Natl Acad Sci U S A. 1982 May; 79(10):3223-7. Raetz CR, Wermuth MM, McIntyre TM, Esko JD, Wing DC. PMID: 6954474.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    264. Animal cells dependent on exogenous phosphatidylcholine for membrane biogenesis. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1698-702. Esko JD, Nishijima M, Raetz CR. PMID: 6281780.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    265. Contact lens induced transient changes in corneal endothelium. Acta Ophthalmol (Copenh). 1981 Aug; 59(4):552-9. Antti V, Jukka M, Jukka S, Reijo A, Esko J. PMID: 7315212.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    266. Thermolabile CDP-choline synthetase in an animal cell mutant defective in lecithin formation. J Biol Chem. 1981 Jul 25; 256(14):7388-93. Esko JD, Wermuth MM, Raetz CR. PMID: 6265447.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    267. Autoradiographic detection of animal cell membrane mutants altered in phosphatidylcholine synthesis. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5192-6. Esko JD, Raetz CR. PMID: 6254065.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    268. Mutants of Chinese hamster ovary cells with altered membrane phospholipid composition. Replacement of phosphatidylinositol by phosphatidylglycerol in a myo-inositol auxotroph. J Biol Chem. 1980 May 25; 255(10):4474-80. Esko JD, Raetz CR. PMID: 7372588.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    269. Replica plating and in situ enzymatic assay of animal cell colonies established on filter paper. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1190-3. Esko JD, Raetz CR. PMID: 349559.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    270. Use of a fluorescent probe to determine the viscosity of LM cell membranes with altered phospholipid compositions. Biochemistry. 1977 May 03; 16(9):1881-90. Esko JD, Gilmore JR, Glaser M. PMID: 192276.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    271. Modification of adenylate cyclase activity in LM cells by manipulation of the membrane phospholipid composition in vivo. Proc Natl Acad Sci U S A. 1976 Dec; 73(12):4482-6. Engelhard VH, Esko JD, Storm DR, Glaser M. PMID: 1069999.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
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