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Jeffrey Esko

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Phone858-822-1100
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    Collapse Biography 
    Collapse Awards and Honors
    NIH1999  - 2009MERIT award
    Society for Glycobiology2007Karl Meyer Award
    Uppsala University2010Doctor of Medicine (honoris causa)
    International Glycoconjugate Organization2011IGO award
    American Association for the Advancement of Science2012Elected Fellow
    NIH2013Director's WALS Lecture

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Glycosylation of the perineuronal net in Alzheimer's Disease
    NIH/NIA R56AG062232Sep 30, 2018 - Aug 31, 2019
    Role: Co-Principal Investigator
    UCSD Biomedical Scientist Career Development Program in Glycoscience
    NIH/NHLBI K12HL141956Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Enhancement of wound healing and regeneration through heparan sulfate deficiency
    NIH/NIAMS R61AR073031Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis
    NIH P01HL131474Jul 15, 2016 - Apr 30, 2021
    Role: Co-Investigator
    5th International MHE Research Conference
    NIH/NIAMS R13AR069987Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator
    Genome-wide Analysis of Heparan Sulfate using CRISPR/Cas9
    NIH/NCI R21CA199292Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Drug Discovery for Multiple Hereditary Exostoses
    NIH/NIAMS R01AR064202Sep 16, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Glycan Modulation of Inflammatory Responses
    NIH P01HL107150Jul 1, 2011 - May 31, 2018
    Role: Co-Investigator
    Structure and Function of 3-O-sulfation in Heparan Sulfate
    NIH/NIGMS R01GM093131May 1, 2010 - Apr 30, 2014
    Role: Principal Investigator
    Gene Discovery and Heparan Sulfate Biogenesis
    NIH/NHLBI R21HL098910Mar 1, 2010 - Dec 31, 2012
    Role: Principal Investigator
    Shared Instrumentation Grant: LTQ Linear Ion Trap Mass Spectrometer
    NIH/NCRR S10RR025507May 1, 2009 - Apr 30, 2010
    Role: Principal Investigator
    Altered endothelial heparan sulfate causes diaphragmatic hernias resembling CDH
    NIH/NICHD R21HD052920May 1, 2006 - Apr 30, 2009
    Role: Principal Investigator
    Glycoside Inhibitors of Tumor Metastasis
    NIH/NCI R01CA112278Feb 9, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Heparan Sulfate--a Novel Target for Cancer Therapeutics
    NIH/NCI U01CA091290Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    GORDON CONFERENCE--PROTEOGLYCANS
    NIH/NIAMS R13AR045230Jul 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    Genetic Modulation of Blood and Vascular Glycosylation
    NIH/NHLBI P01HL057345Sep 30, 1997 - Dec 31, 2013
    Role: Co-Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    GLYCOSIDE ANTAGONISTS OF GLYCOSYLATION
    NIH/NCI R01CA046462Apr 20, 1990 - Jun 30, 2002
    Role: Principal Investigator
    Genetic analysis of proteoglycan-mediated lipoprotein clearance
    NIH/NIGMS R01GM033063Jul 1, 1983 - Apr 30, 2020
    Role: Principal Investigator
    GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    NIH/NIGMS R37GM033063Jul 1, 1983 - Nov 30, 2010
    Role: Principal Investigator
    SCOR IN ACUTE LUNG INJURY
    NIH/NHLBI P50HL023584Dec 1, 1978 - Nov 30, 2003
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kegulian NC, Ramms B, Horton S, Trenchevska O, Nedelkov D, Graham MJ, Lee RG, Esko JD, Yassine HN, Gordts PLSM. ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors. Arterioscler Thromb Vasc Biol. 2019 Aug 08; ATVBAHA119312723. PMID: 31390883.
      View in: PubMed
    2. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2019 Jul 17. PMID: 31315930.
      View in: PubMed
    3. Anower-E-Khuda F, Singh G, Deng Y, Gordts PLSM, Esko JD. Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants. Glycobiology. 2019 May 16. PMID: 31094413.
      View in: PubMed
    4. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. ApoC-III ASO Promotes Tissue LPL Activity in Absence of ApoE-Mediated TRL Clearance. J Lipid Res. 2019 May 14. PMID: 31092690.
      View in: PubMed
    5. Pimienta G, Heithoff DM, Rosa-Campos A, Tran M, Esko JD, Mahan MJ, Marth JD, Smith JW. Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network. Proteomics. 2019 Mar; 19(5):e1800389. PMID: 30706660.
      View in: PubMed
    6. Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods. 2018 Nov; 15(11):889-899. PMID: 30377379.
      View in: PubMed
    7. Thieker DF, Xu Y, Chapla D, Nora C, Qiu H, Felix T, Wang L, Moremen KW, Liu J, Esko JD, Woods RJ. Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase. Sci Rep. 2018 Aug 07; 8(1):11832. PMID: 30087361.
      View in: PubMed
    8. Gordts PLSM, Esko JD. The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biol. 2018 10; 71-72:262-282. PMID: 29803939.
      View in: PubMed
    9. Ge XN, Bastan I, Ha SG, Greenberg YG, Esko JD, Rao SP, Sriramarao P. Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes. Exp Lung Res. 2018 03; 44(2):98-112. PMID: 29621420.
      View in: PubMed
    10. Alavi Naini SM, Yanicostas C, Hassan-Abdi R, Blondeel S, Bennis M, Weiss RJ, Tor Y, Esko JD, Soussi-Yanicostas N. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. 2018; 7:6. PMID: 29568517.
      View in: PubMed
    11. Spahn PN, Bath T, Weiss RJ, Kim J, Esko JD, Lewis NE, Harismendy O. PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens. Sci Rep. 2017 Nov 20; 7(1):15854. PMID: 29158538.
      View in: PubMed
    12. Phan AQ, Pacifici M, Esko JD. Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference. Connect Tissue Res. 2018 01; 59(1):85-98. PMID: 29099240.
      View in: PubMed
    13. Hadidi K, Wexselblatt E, Esko JD, Tor Y. Cellular uptake of modified aminoglycosides. J Antibiot (Tokyo). 2017 Nov 01. PMID: 29089598.
      View in: PubMed
    14. Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. 2017 08 21; 7(1):9008. PMID: 28827536.
      View in: PubMed
    15. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. PMID: 28958576.
      View in: PubMed
    16. Weiss RJ, Esko JD, Tor Y. Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 2017 Jul 21; 15(27):5656-5668. PMID: 28653068.
      View in: PubMed
    17. Dwyer CA, Scudder SL, Lin Y, Dozier LE, Phan D, Allen NJ, Patrick GN, Esko JD. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017 Apr 18; 7:46576. PMID: 28418018.
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    18. Dhamale OP, Lawrence R, Wiegmann EM, Shah BA, Al-Mafraji K, Lamanna WC, Lübke T, Dierks T, Boons GJ, Esko JD. Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chem Biol. 2017 02 17; 12(2):367-373. PMID: 28055182.
      View in: PubMed
    19. van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin a2 as a Host Factor for Bacterial Invasion. MBio. 2017 01 10; 8(1). PMID: 28074024.
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    20. Hamill KM, Wexselblatt E, Tong W, Esko JD, Tor Y. Delivery of Cargo to Lysosomes Using GNeosomes. Methods Mol Biol. 2017; 1594:151-163. PMID: 28456981.
      View in: PubMed
    21. Sganappa A, Wexselblatt E, Bellucci MC, Esko JD, Tedeschi G, Tor Y, Volonterio A. Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules. Chembiochem. 2017 Jan 03; 18(1):119-125. PMID: 27806190.
      View in: PubMed
    22. Dwyer CA, Esko JD. Glycan susceptibility factors in autism spectrum disorders. Mol Aspects Med. 2016 10; 51:104-14. PMID: 27418189.
      View in: PubMed
    23. Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 08 01; 126(8):2855-66. PMID: 27400128.
      View in: PubMed
    24. Hamill KM, McCoy LS, Wexselblatt E, Esko JD, Tor Y. Polymyxins Facilitate Entry into Mammalian Cells. Chem Sci. 2016 Aug 01; 7(8):5059-5068. PMID: 28044098.
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    25. Khalid O, Vera MU, Gordts PL, Ellinwood NM, Schwartz PH, Dickson PI, Esko JD, Wang RY. Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. PLoS One. 2016; 11(3):e0150850. PMID: 26986213.
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    26. Thacker BE, Seamen E, Lawrence R, Parker MW, Xu Y, Liu J, Vander Kooi CW, Esko JD. Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity. ACS Chem Biol. 2016 Apr 15; 11(4):971-80. PMID: 26731579.
      View in: PubMed
    27. Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko JD, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi CR, Etzler ME, Frank M, Vliegenthart JF, Lütteke T, Perez S, Bolton E, Rudd P, Paulson J, Kanehisa M, Toukach P, Aoki-Kinoshita KF, Dell A, Narimatsu H, York W, Taniguchi N, Kornfeld S. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 2015 Dec; 25(12):1323-4. PMID: 26543186; PMCID: PMC4643639 [Available on 12/01/16].
    28. Zaiss AK, Foley EM, Lawrence R, Schneider LS, Hoveida H, Secrest P, Catapang AB, Yamaguchi Y, Alemany R, Shayakhmetov DM, Esko JD, Herschman HR. Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo. J Virol. 2016 01 01; 90(1):412-20. PMID: 26491162.
      View in: PubMed
    29. Weiss RJ, Gordts PL, Le D, Xu D, Esko JD, Tor Y. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. PMID: 28133533.
      View in: PubMed
    30. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. PMID: 26150541; PMCID: PMC4534644.
    31. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. PMID: 25995222.
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    32. Marki A, Esko JD, Pries AR, Ley K. Role of the endothelial surface layer in neutrophil recruitment. J Leukoc Biol. 2015 Oct; 98(4):503-15. PMID: 25979432; PMCID: PMC4569049 [Available on 10/01/16].
    33. Coulson-Thomas VJ, Chang SH, Yeh LK, Coulson-Thomas YM, Yamaguchi Y, Esko J, Liu CY, Kao W. Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci. 2015 May; 56(5):3004-14. PMID: 26024086; PMCID: PMC4432551.
    34. Wexselblatt E, Esko JD, Tor Y. GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery. ACS Nano. 2015; 9(4):3961-8. PMID: 25831231.
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    35. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagiroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015 May; 47(5):528-34. PMID: 25848753; PMCID: PMC4414867.
    36. Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10; 6:6356. PMID: 25754609; PMCID: PMC4366535.
    37. Mooij HL, Bernelot Moens SJ, Gordts PL, Stanford KI, Foley EM, van den Boogert MA, Witjes JJ, Hassing HC, Tanck MW, van de Sande MA, Levels JH, Kastelein JJ, Stroes ES, Dallinga-Thie GM, Esko JD, Nieuwdorp M. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res. 2015 Mar; 56(3):665-73. PMID: 25568062; PMCID: PMC4340313.
    38. Gordts PL, Esko JD. Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-ß. Cytokine. 2015 Mar; 72(1):118-9. PMID: 25573804.
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    39. Bernelot Moens SJ, Mooij HL, Hassing HC, Kruit JK, Witjes JJ, van de Sande MA, Nederveen AJ, Xu D, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M. Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume. PLoS One. 2014; 9(12):e115662. PMID: 25541963.
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    40. Mooij HL, Cabrales P, Bernelot Moens SJ, Xu D, Udayappan SD, Tsai AG, van der Sande MA, de Groot E, Intaglietta M, Kastelein JJ, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M. Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc. 2014 Dec 02; 3(6):e001274. PMID: 25468659; PMCID: PMC4338717.
    41. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. PMID: 25440058.
      View in: PubMed
    42. Wen J, Xiao J, Rahdar M, Choudhury BP, Cui J, Taylor GS, Esko JD, Dixon JE. Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15723-8. PMID: 25331875; PMCID: PMC4226115.
    43. Coulson-Thomas VJ, Gesteira TF, Esko J, Kao W. Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem. 2014 Sep 05; 289(36):25211-26. PMID: 25053416; PMCID: PMC4155684.
    44. Wexselblatt E, Esko JD, Tor Y. On guanidinium and cellular uptake. J Org Chem. 2014 Aug 01; 79(15):6766-74. PMID: 25019333.
      View in: PubMed
    45. Wang RY, Aminian A, McEntee MF, Kan SH, Simonaro CM, Lamanna WC, Lawrence R, Ellinwood NM, Guerra C, Le SQ, Dickson PI, Esko JD. Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I. Mol Genet Metab. 2014 Aug; 112(4):286-93. PMID: 24951454; PMCID: PMC4122635.
    46. Ge XN, Ha SG, Rao A, Greenberg YG, Rushdi MN, Esko JD, Rao SP, Sriramarao P. Endothelial and leukocyte heparan sulfates regulate the development of allergen-induced airway remodeling in a mouse model. Glycobiology. 2014 Aug; 24(8):715-27. PMID: 24794009.
      View in: PubMed
    47. Rops AL, Loeven MA, van Gemst JJ, Eversen I, Van Wijk XM, Dijkman HB, van Kuppevelt TH, Berden JH, Rabelink TJ, Esko JD, van der Vlag J. Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney Int. 2014 Nov; 86(5):932-42. PMID: 24759151.
      View in: PubMed
    48. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. PMID: 24726386; PMCID: PMC4143151.
    49. Inoue M, Wexselblatt E, Esko JD, Tor Y. Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters. Chembiochem. 2014 Mar 21; 15(5):676-80. PMID: 24677320; PMCID: PMC4216228.
    50. Xu D, Esko JD. Demystifying heparan sulfate-protein interactions. Annu Rev Biochem. 2014; 83:129-57. PMID: 24606135.
      View in: PubMed
    51. Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li D, Linhardt RJ, Esko JD, Wang L. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan; 124(1):209-21. PMID: 24355925; PMCID: PMC3871243.
    52. Thacker BE, Xu D, Lawrence R, Esko JD. Heparan sulfate 3-O-sulfation: a rare modification in search of a function. Matrix Biol. 2014 Apr; 35:60-72. PMID: 24361527; PMCID: PMC4039620.
    53. Gasimli L, Glass CA, Datta P, Yang B, Li G, Gemmill TR, Baik JY, Sharfstein ST, Esko JD, Linhardt RJ. Bioengineering murine mastocytoma cells to produce anticoagulant heparin. Glycobiology. 2014 Mar; 24(3):272-80. PMID: 24326668; PMCID: PMC3919470.
    54. Pan Y, Carbe C, Kupich S, Pickhinke U, Ohlig S, Frye M, Seelige R, Pallerla SR, Moon AM, Lawrence R, Esko JD, Zhang X, Grobe K. Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis. Matrix Biol. 2014 Apr; 35:253-65. PMID: 24200809; PMCID: PMC4324438.
    55. Sugar T, Wassenhove-McCarthy DJ, Esko JD, van Kuppevelt TH, Holzman L, McCarthy KJ. Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo. Kidney Int. 2014 Feb; 85(2):307-18. PMID: 23924956; PMCID: PMC4624314.
    56. Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko JD. Glycan-based biomarkers for mucopolysaccharidoses. Mol Genet Metab. 2014 Feb; 111(2):73-83. PMID: 23958290; PMCID: PMC3769472.
    57. Foley EM, Gordts PLSM, Stanford KI, Gonzales JC, Lawrence R, Stoddard N, Esko JD. Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2065-74. PMID: 23846497; PMCID: PMC3821931.
    58. Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013 Jul 19; 8(7):1611-20. PMID: 23679870; PMCID: PMC3806902.
    59. Gonzales JC, Gordts PL, Foley EM, Esko JD. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest. 2013 Jun; 123(6):2742-51. PMID: 23676495; PMCID: PMC3668842.
    60. Inoue M, Tong W, Esko JD, Tor Y. Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol. 2013 Jul 19; 8(7):1383-8. PMID: 23621420; PMCID: PMC3773245.
    61. Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko JD. WITHDRAWN: Glycan-based biomarkers for mucopolysaccharidoses. Dis Markers. 2013 Feb 08. PMID: 23396297.
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    62. Cantley L, Saunders C, Guttenberg M, Candela ME, Ohta Y, Yasuhara R, Kondo N, Sgariglia F, Asai S, Zhang X, Qin L, Hecht JT, Chen D, Yamamoto M, Toyosawa S, Dormans JP, Esko JD, Yamaguchi Y, Iwamoto M, Pacifici M, Enomoto-Iwamoto M. Loss of ß-catenin induces multifocal periosteal chondroma-like masses in mice. Am J Pathol. 2013 Mar; 182(3):917-27. PMID: 23274133.
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    63. Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 07; 287(50):42064-70. PMID: 23060443; PMCID: PMC3516752.
    64. Lamanna WC, Lawrence R, Sarrazin S, Lameda-Diaz C, Gordts PL, Moremen KW, Esko JD. A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 2012 Oct 19; 287(43):36283-90. PMID: 22952226; PMCID: PMC3476295.
    65. Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012 Aug 23; 120(8):1742-51. PMID: 22791291; PMCID: PMC3429312.
    66. Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. J Biol Chem. 2012 Aug 17; 287(34):28898-916. PMID: 22692203; PMCID: PMC3436526.
    67. Kowalewski B, Lamanna WC, Lawrence R, Damme M, Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D'Hooge R, Esko JD, Dierks T. Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10310-5. PMID: 22689975; PMCID: PMC3387061.
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    71. Deng Y, Foley EM, Gonzales JC, Gordts PL, Li Y, Esko JD. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology. 2012 Jan; 55(1):277-86. PMID: 21898481; PMCID: PMC3245353.
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    76. Chang YC, Wang Z, Flax LA, Xu D, Esko JD, Nizet V, Baron MJ. Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog. 2011 Jun; 7(6):e1002082. PMID: 21731486.
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    78. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko JD, Nigam SK. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 01; 356(1):19-27. PMID: 21600196; PMCID: PMC3130836.
    79. Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011 Jul 15; 355(2):394-403. PMID: 21586278; PMCID: PMC3118867.
    80. Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X. Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem. 2011 Apr 22; 286(16):14435-44. PMID: 21357686; PMCID: PMC3077643.
    81. Zak BM, Schuksz M, Koyama E, Mundy C, Wells DE, Yamaguchi Y, Pacifici M, Esko JD. Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones. Bone. 2011 May 01; 48(5):979-87. PMID: 21310272; PMCID: PMC3335264.
    82. Lamanna WC, Lawrence R, Sarrazin S, Esko JD. Secondary storage of dermatan sulfate in Sanfilippo disease. J Biol Chem. 2011 Mar 04; 286(9):6955-62. PMID: 21193389; PMCID: PMC3044951.
    83. Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919. PMID: 21085708; PMCID: PMC2978080.
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    85. Xu D, Fuster MM, Lawrence R, Esko JD. Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability. J Biol Chem. 2011 Jan 07; 286(1):737-45. PMID: 20974861.
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    87. Dai E, Liu LY, Wang H, McIvor D, Sun YM, Macaulay C, King E, Munuswamy-Ramanujam G, Bartee MY, Williams J, Davids J, Charo I, McFadden G, Esko JD, Lucas AR. Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection. PLoS One. 2010 May 06; 5(5):e10510. PMID: 20463901; PMCID: PMC2865544.
    88. Sarrazin S, Wilson B, Sly WS, Tor Y, Esko JD. Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes. Mol Ther. 2010 Jul; 18(7):1268-74. PMID: 20442709; PMCID: PMC2911259.
    89. Bishop JR, Foley E, Lawrence R, Esko JD. Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate. J Biol Chem. 2010 May 07; 285(19):14658-62. PMID: 20236939; PMCID: PMC2863227.
    90. Adhikari N, Basi DL, Townsend D, Rusch M, Mariash A, Mullegama S, Watson A, Larson J, Tan S, Lerman B, Esko JD, Selleck SB, Hall JL. Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling. J Mol Cell Cardiol. 2010 Aug; 49(2):287-93. PMID: 20206635; PMCID: PMC2885463.
    91. Gesteira TF, Coulson-Thomas VJ, Taunay-Rodrigues A, Oliveira V, Thacker BE, Juliano MA, Pasqualini R, Arap W, Tersariol IL, Nader HB, Esko JD, Pinhal MA. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. J Biol Chem. 2011 Feb 18; 286(7):5338-46. PMID: 20129923; PMCID: PMC3037646.
    92. Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush KT, Esko JD, Nigam SK. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol. 2010 Mar 15; 339(2):354-65. PMID: 20059993; PMCID: PMC2834281.
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    94. Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Marth JD, Bertozzi CR, Hart GW, Etzler ME. Symbol nomenclature for glycan representation. Proteomics. 2009 Dec; 9(24):5398-9. PMID: 19902428.
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    97. Zhang B, Dietrich UM, Geng JG, Bicknell R, Esko JD, Wang L. Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 05; 114(19):4300-9. PMID: 19741192; PMCID: PMC2774558.
    98. Xu D, Esko JD. A Golgi-on-a-chip for glycan synthesis. Nat Chem Biol. 2009 Sep; 5(9):612-3. PMID: 19690535.
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    100. Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M. A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol. 2009 07 31; 16(7):773-82. PMID: 19635414.
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    101. Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK, Esko JD. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem. 2009 Feb 20; 284(8):4952-9. PMID: 19106107.
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    102. Meissen JK, Sweeney MD, Girardi M, Lawrence R, Esko JD, Leary JA. Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif. J Am Soc Mass Spectrom. 2009 Apr; 20(4):652-7. PMID: 19185514; PMCID: PMC2758813.
    103. Bakker H, Oka T, Ashikov A, Yadav A, Berger M, Rana NA, Bai X, Jigami Y, Haltiwanger RS, Esko JD, Gerardy-Schahn R. Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem. 2009 Jan 23; 284(4):2576-83. PMID: 19028698; PMCID: PMC2629108.
    104. Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem. 2008 Dec 12; 283(50):34511-8. PMID: 18845532.
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    105. Lawrence R, Olson SK, Steele RE, Wang L, Warrior R, Cummings RD, Esko JD. Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling. J Biol Chem. 2008 Nov 28; 283(48):33674-84. PMID: 18818196.
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    106. Schuksz M, Fuster MM, Brown JR, Crawford BE, Ditto DP, Lawrence R, Glass CA, Wang L, Tor Y, Esko JD. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13075-80. PMID: 18725627.
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    107. Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology. 2008 Oct; 18(10):747-9. PMID: 18621991.
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    108. Bishop JR, Stanford KI, Esko JD. Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism. Curr Opin Lipidol. 2008 Jun; 19(3):307-13. PMID: 18460924.
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    109. Garner OB, Yamaguchi Y, Esko JD, Videm V. Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate. Immunology. 2008 Nov; 125(3):420-9. PMID: 18479348; PMCID: PMC2669145.
    110. Pallerla SR, Lawrence R, Lewejohann L, Pan Y, Fischer T, Schlomann U, Zhang X, Esko JD, Grobe K. Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem. 2008 Jun 13; 283(24):16885-94. PMID: 18385133.
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    111. Lawrence R, Lu H, Rosenberg RD, Esko JD, Zhang L. Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans. Nat Methods. 2008 Apr; 5(4):291-2. PMID: 18376390.
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    112. Bode L, Salvestrini C, Park PW, Li JP, Esko JD, Yamaguchi Y, Murch S, Freeze HH. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest. 2008 Jan; 118(1):229-38. PMID: 18064305; PMCID: PMC2117765.
    113. Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development. 2008 Jan; 135(2):301-10. PMID: 18077586.
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    114. Coppi A, Tewari R, Bishop JR, Bennett BL, Lawrence R, Esko JD, Billker O, Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe. 2007 Nov 15; 2(5):316-27. PMID: 18005753; PMCID: PMC2117360.
    115. Brown JR, Crawford BE, Esko JD. Glycan antagonists and inhibitors: a fount for drug discovery. Crit Rev Biochem Mol Biol. 2007 Nov-Dec; 42(6):481-515. PMID: 18066955.
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    116. Fuster MM, Wang L, Castagnola J, Sikora L, Reddi K, Lee PH, Radek KA, Schuksz M, Bishop JR, Gallo RL, Sriramarao P, Esko JD. Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis. J Cell Biol. 2007 May 07; 177(3):539-49. PMID: 17470635; PMCID: PMC2064806.
    117. Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature. 2007 Apr 26; 446(7139):1030-7. PMID: 17460664.
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    118. Johnson CE, Crawford BE, Stavridis M, Ten Dam G, Wat AL, Rushton G, Ward CM, Wilson V, van Kuppevelt TH, Esko JD, Smith A, Gallagher JT, Merry CL. Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Stem Cells. 2007 Aug; 25(8):1913-23. PMID: 17464092.
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    119. Borsig L, Wang L, Cavalcante MC, Cardilo-Reis L, Ferreira PL, Mourão PA, Esko JD, Pavão MS. Selectin blocking activity of a fucosylated chondroitin sulfate glycosaminoglycan from sea cucumber. Effect on tumor metastasis and neutrophil recruitment. J Biol Chem. 2007 May 18; 282(20):14984-91. PMID: 17371880.
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    120. Elson-Schwab L, Garner OB, Schuksz M, Crawford BE, Esko JD, Tor Y. Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway. J Biol Chem. 2007 May 04; 282(18):13585-91. PMID: 17311923.
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    121. Pallerla SR, Pan Y, Zhang X, Esko JD, Grobe K. Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Dev Dyn. 2007 Feb; 236(2):556-63. PMID: 17183530.
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    122. MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum JL, Esko JD. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest. 2007 Jan; 117(1):153-64. PMID: 17200715; PMCID: PMC1716206.
    123. Pönighaus C, Ambrosius M, Casanova JC, Prante C, Kuhn J, Esko JD, Kleesiek K, Götting C. Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans. J Biol Chem. 2007 Feb 23; 282(8):5201-6. PMID: 17189265.
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    124. Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006 Dec; 133(24):4933-44. PMID: 17107998.
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    125. Olson SK, Bishop JR, Yates JR, Oegema K, Esko JD. Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. J Cell Biol. 2006 Jun 19; 173(6):985-94. PMID: 16785326; PMCID: PMC2063922.
    126. Brown JR, Fuster MM, Li R, Varki N, Glass CA, Esko JD. A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination. Clin Cancer Res. 2006 May 01; 12(9):2894-901. PMID: 16675586.
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    127. Clamp A, Blackhall FH, Henrioud A, Jayson GC, Javaherian K, Esko J, Gallagher JT, Merry CL. The morphogenic properties of oligomeric endostatin are dependent on cell surface heparan sulfate. J Biol Chem. 2006 May 26; 281(21):14813-22. PMID: 16481316.
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    128. Zhang L, Lawrence R, Frazier BA, Esko JD. CHO glycosylation mutants: proteoglycans. Methods Enzymol. 2006; 416:205-21. PMID: 17113868.
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    129. Brown JR, Nishimura Y, Esko JD. Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to L-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase. Bioorg Med Chem Lett. 2006 Feb; 16(3):532-6. PMID: 16275065.
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    130. Stickens D, Zak BM, Rougier N, Esko JD, Werb Z. Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 2005 Nov; 132(22):5055-68. PMID: 16236767; PMCID: PMC2767329.
    131. Comelli EM, Head SR, Gilmartin T, Whisenant T, Haslam SM, North SJ, Wong NK, Kudo T, Narimatsu H, Esko JD, Drickamer K, Dell A, Paulson JC. A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology. 2006 Feb; 16(2):117-31. PMID: 16237199.
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    132. Bishop JR, Crawford BE, Esko JD. Cell surface heparan sulfate promotes replication of Toxoplasma gondii. Infect Immun. 2005 Sep; 73(9):5395-401. PMID: 16113255; PMCID: PMC1231081.
    133. Wang L, Fuster M, Sriramarao P, Esko JD. Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol. 2005 Sep; 6(9):902-10. PMID: 16056228.
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    134. Rele SM, Cui W, Wang L, Hou S, Barr-Zarse G, Tatton D, Gnanou Y, Esko JD, Chaikof EL. Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties. J Am Chem Soc. 2005 Jul 27; 127(29):10132-3. PMID: 16028900.
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    135. Grobe K, Inatani M, Pallerla SR, Castagnola J, Yamaguchi Y, Esko JD. Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function. Development. 2005 Aug; 132(16):3777-86. PMID: 16020517.
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    136. Fuster MM, Esko JD. The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer. 2005 Jul; 5(7):526-42. PMID: 16069816.
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    137. Bishop JR, Esko JD. The elusive role of heparan sulfate in Toxoplasma gondii infection. Mol Biochem Parasitol. 2005 Feb; 139(2):267-9. PMID: 15664661.
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    138. Kinnunen T, Huang Z, Townsend J, Gatdula MM, Brown JR, Esko JD, Turnbull JE. Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1507-12. PMID: 15671174; PMCID: PMC547812.
    139. Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 2004 Nov; 6(5):485-95. PMID: 15542432.
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    140. Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004 Aug 15; 272(2):310-27. PMID: 15282150.
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    141. Nagai N, Habuchi H, Esko JD, Kimata K. Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity. J Cell Sci. 2004 Jul 01; 117(Pt 15):3331-41. PMID: 15226404.
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    142. Bobardt MD, Salmon P, Wang L, Esko JD, Gabuzda D, Fiala M, Trono D, Van der Schueren B, David G, Gallay PA. Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol. 2004 Jun; 78(12):6567-84. PMID: 15163749; PMCID: PMC416544.
    143. Wei G, Bai X, Esko JD. Temperature-sensitive glycosaminoglycan biosynthesis in a Chinese hamster ovary cell mutant containing a point mutation in glucuronyltransferase I. J Biol Chem. 2004 Feb 13; 279(7):5693-8. PMID: 14623881.
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    144. Mong TK, Lee LV, Brown JR, Esko JD, Wong CH. Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expression. Chembiochem. 2003 Sep 05; 4(9):835-40. PMID: 12964157.
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    145. Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Müller R, Brown JR, Hennet T, Esko JD, Aroian RV. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. J Biol Chem. 2003 Nov 14; 278(46):45594-602. PMID: 12944392.
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    146. Ben-Zaken O, Tzaban S, Tal Y, Horonchik L, Esko JD, Vlodavsky I, Taraboulos A. Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem. 2003 Oct 10; 278(41):40041-9. PMID: 12871949.
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    147. Fuster MM, Brown JR, Wang L, Esko JD. A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells. Cancer Res. 2003 Jun 01; 63(11):2775-81. PMID: 12782582.
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    148. Hwang HY, Olson SK, Esko JD, Horvitz HR. Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature. 2003 May 22; 423(6938):439-43. PMID: 12761549.
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    149. Brown JR, Fuster MM, Whisenant T, Esko JD. Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys. J Biol Chem. 2003 Jun 27; 278(26):23352-9. PMID: 12686549.
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    150. Hwang HY, Olson SK, Brown JR, Esko JD, Horvitz HR. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. J Biol Chem. 2003 Apr 04; 278(14):11735-8. PMID: 12584198.
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    151. Zak BM, Crawford BE, Esko JD. Hereditary multiple exostoses and heparan sulfate polymerization. Biochim Biophys Acta. 2002 Dec 19; 1573(3):346-55. PMID: 12417417.
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    152. Grobe K, Ledin J, Ringvall M, Holmborn K, Forsberg E, Esko JD, Kjellén L. Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes. Biochim Biophys Acta. 2002 Dec 19; 1573(3):209-15. PMID: 12417402.
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    153. Ford-Perriss M, Guimond SE, Greferath U, Kita M, Grobe K, Habuchi H, Kimata K, Esko JD, Murphy M, Turnbull JE. Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology. 2002 Nov; 12(11):721-7. PMID: 12460940.
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    154. Mertsching E, Wurster AL, Katayama C, Esko J, Ramsdell F, Marth JD, Hedrick SM. A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment. Int Immunol. 2002 Sep; 14(9):1039-53. PMID: 12202401.
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    155. Wang L, Brown JR, Varki A, Esko JD. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest. 2002 Jul; 110(1):127-36. PMID: 12093896; PMCID: PMC151027.
    156. Grobe K, Esko JD. Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites. J Biol Chem. 2002 Aug 23; 277(34):30699-706. PMID: 12070138.
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    157. Guibinga GH, Miyanohara A, Esko JD, Friedmann T. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther. 2002 May; 5(5 Pt 1):538-46. PMID: 11991744.
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    158. Yabushita H, Noguchi Y, Habuchi H, Ashikari S, Nakabe K, Fujita M, Noguchi M, Esko JD, Kimata K. Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture. Glycobiology. 2002 May; 12(5):345-51. PMID: 12070077.
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    159. Belting M, Borsig L, Fuster MM, Brown JR, Persson L, Fransson LA, Esko JD. Tumor attenuation by combined heparan sulfate and polyamine depletion. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):371-6. PMID: 11752393; PMCID: PMC117567.
    160. Esko JD, Selleck SB. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem. 2002; 71:435-71. PMID: 12045103.
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    161. Pinhal MA, Smith B, Olson S, Aikawa J, Kimata K, Esko JD. Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):12984-9. PMID: 11687650.
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    162. Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD. Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). J Biol Chem. 2001 Dec 21; 276(51):48189-95. PMID: 11551958.
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    163. Bai X, Brown JR, Varki A, Esko JD. Enhanced 3-O-sulfation of galactose in Asn-linked glycans and Maackia amurensis lectin binding in a new Chinese hamster ovary cell line. Glycobiology. 2001 Aug; 11(8):621-32. PMID: 11479273.
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    164. Esko JD, Lindahl U. Molecular diversity of heparan sulfate. J Clin Invest. 2001 Jul; 108(2):169-73. PMID: 11457867; PMCID: PMC203033.
    165. Cheung PK, McCormick C, Crawford BE, Esko JD, Tufaro F, Duncan G. Etiological point mutations in the hereditary multiple exostoses gene EXT1: a functional analysis of heparan sulfate polymerase activity. Am J Hum Genet. 2001 Jul; 69(1):55-66. PMID: 11391482.
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    166. Zhang L, Lawrence R, Schwartz JJ, Bai X, Wei G, Esko JD, Rosenberg RD. The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate. J Biol Chem. 2001 Aug 03; 276(31):28806-13. PMID: 11375390.
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    167. Morii E, Ogihara H, Oboki K, Sawa C, Sakuma T, Nomura S, Esko JD, Handa H, Kitamura Y. Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells. Blood. 2001 May 15; 97(10):3032-9. PMID: 11342428.
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    168. Pinzon-Ortiz C, Friedman J, Esko J, Sinnis P. The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for plasmodium sporozoite attachment to target cells. J Biol Chem. 2001 Jul 20; 276(29):26784-91. PMID: 11352923.
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    169. Esko JD. Special considerations for proteoglycans and glycosaminoglycans and their purification. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.2. PMID: 18265153.
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    170. Esko JD, Montgomery RI. Synthetic glycosides as primers of oligosaccharide biosynthesis and inhibitors of glycoprotein and proteoglycan assembly. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.11. PMID: 18265139.
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    171. Manzi A, Esko J. Direct chemical analysis of glycoconjugates for carbohydrates. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.9. PMID: 18265165.
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    172. Crawford BE, Olson SK, Esko JD, Pinhal MA. Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase. J Biol Chem. 2001 Jun 15; 276(24):21538-43. PMID: 11279150.
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    173. Bai X, Crawford B, Esko JD. Selection of glycosaminoglycan-deficient mutants. Methods Mol Biol. 2001; 171:309-16. PMID: 11450242.
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    174. Fritz TA, Esko JD. Xyloside priming of glycosaminoglycan biosynthesis and inhibition of proteoglycan assembly. Methods Mol Biol. 2001; 171:317-23. PMID: 11450243.
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    175. Aikawa J, Grobe K, Tsujimoto M, Esko JD. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. J Biol Chem. 2001 Feb 23; 276(8):5876-82. PMID: 11087757.
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    176. Sarkar AK, Brown JR, Esko JD. Synthesis and glycan priming activity of acetylated disaccharides. Carbohydr Res. 2000 Nov 03; 329(2):287-300. PMID: 11117312.
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    177. Bulik DA, Wei G, Toyoda H, Kinoshita-Toyoda A, Waldrip WR, Esko JD, Robbins PW, Selleck SB. sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10838-43. PMID: 11005858.
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    178. Wei G, Bai X, Gabb MM, Bame KJ, Koshy TI, Spear PG, Esko JD. Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants. J Biol Chem. 2000 Sep 08; 275(36):27733-40. PMID: 10864928.
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    179. Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MM. Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15; 224(2):299-311. PMID: 10926768.
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    180. Norgard-Sumnicht K, Bai X, Esko JD, Varki A, Manzi AE. Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans. Glycobiology. 2000 Jul; 10(7):691-700. PMID: 10910973.
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    181. Shukla D, Liu J, Blaiklock P, Shworak NW, Bai X, Esko JD, Cohen GH, Eisenberg RJ, Rosenberg RD, Spear PG. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell. 1999 Oct 01; 99(1):13-22. PMID: 10520990.
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    182. Sinha A, Taylor WH, Khan IH, McDaniel ST, Esko JD. Glycoside primers of Psittacanthus cucullaris. J Nat Prod. 1999 Jul; 62(7):1036-8. PMID: 10425137.
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    183. Bai X, Wei G, Sinha A, Esko JD. Chinese hamster ovary cell mutants defective in glycosaminoglycan assembly and glucuronosyltransferase I. J Biol Chem. 1999 May 07; 274(19):13017-24. PMID: 10224052.
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    184. Wei G, Bai X, Sarkar AK, Esko JD. Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:Galactose beta1, 3-glucuronosyltransferases. J Biol Chem. 1999 Mar 19; 274(12):7857-64. PMID: 10075678.
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    185. Aikawa J, Esko JD. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. J Biol Chem. 1999 Jan 29; 274(5):2690-5. PMID: 9915799.
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    186. Taylor WH, Sinha A, Khan IA, McDaniel ST, Esko JD. Primers of glycosaminoglycan biosynthesis from Peruvian rain forest plants. J Biol Chem. 1998 Aug 28; 273(35):22260-6. PMID: 9712841.
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    187. Sarkar AK, Rostand KS, Jain RK, Matta KL, Esko JD. Fucosylation of disaccharide precursors of sialyl LewisX inhibit selectin-mediated cell adhesion. J Biol Chem. 1997 Oct 10; 272(41):25608-16. PMID: 9325281.
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    188. Bai X, Bame KJ, Habuchi H, Kimata K, Esko JD. Turnover of heparan sulfate depends on 2-O-sulfation of uronic acids. J Biol Chem. 1997 Sep 12; 272(37):23172-9. PMID: 9287321.
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    189. Gantt SM, Clavijo P, Bai X, Esko JD, Sinnis P. Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG. J Biol Chem. 1997 Aug 01; 272(31):19205-13. PMID: 9235912.
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    190. Chen Y, Maguire T, Hileman RE, Fromm JR, Esko JD, Linhardt RJ, Marks RM. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nat Med. 1997 Aug; 3(8):866-71. PMID: 9256277.
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    191. Fritz TA, Agrawal PK, Esko JD, Krishna NR. Partial purification and substrate specificity of heparan sulfate alpha-N-acetylglucosaminyltransferase I: synthesis, NMR spectroscopic characterization and in vitro assays of two aryl tetrasaccharides. Glycobiology. 1997 Jul; 7(5):587-95. PMID: 9254041.
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    192. Rostand KS, Esko JD. Microbial adherence to and invasion through proteoglycans. Infect Immun. 1997 Jan; 65(1):1-8. PMID: 8975885.
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    193. Esko JD, Zhang L. Influence of core protein sequence on glycosaminoglycan assembly. Curr Opin Struct Biol. 1996 Oct; 6(5):663-70. PMID: 8913690.
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    194. Lugemwa FN, Sarkar AK, Esko JD. Unusual beta-D-xylosides that prime glycosaminoglycans in animal cells. J Biol Chem. 1996 Aug 09; 271(32):19159-65. PMID: 8702593.
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    195. Bai X, Esko JD. An animal cell mutant defective in heparan sulfate hexuronic acid 2-O-sulfation. J Biol Chem. 1996 Jul 26; 271(30):17711-7. PMID: 8663454.
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    196. Olivecrona G, Vilaró S, Esko JD, Olivecrona T. Synthesis and secretion of lipoprotein lipase in heparan sulfate-deficient Chinese hamster ovary cells. Isr J Med Sci. 1996 Jun; 32(6):430-44. PMID: 8682648.
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    197. Frevert U, Sinnis P, Esko JD, Nussenzweig V. Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):257-66. PMID: 8920011.
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    198. Sarkar AK, Esko JD. Synthesis and glycosaminoglycan priming activity of three disaccharides related to the linkage region tetrasaccharide of proteoglycans. Carbohydr Res. 1995 Dec 27; 279:161-71. PMID: 8593621.
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    199. Zhang L, David G, Esko JD. Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans. J Biol Chem. 1995 Nov 10; 270(45):27127-35. PMID: 7592967.
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    200. Moore DR, Smith A, Hager KM, Waldon R, Esko JD, Hajduk SL. Developmentally regulated sensitivity of Trypanosoma brucei brucei to the cytotoxic effects of human high-density lipoprotein. Exp Parasitol. 1995 Sep; 81(2):216-26. PMID: 7556564.
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    201. Zhang L, Esko JD. Accumulation of a pentasaccharide terminating in alpha-N-acetylglucosamine in an animal cell mutant defective in heparan sulfate biosynthesis. J Biol Chem. 1995 May 26; 270(21):12557-62. PMID: 7759502.
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    202. Smith AB, Esko JD, Hajduk SL. Killing of trypanosomes by the human haptoglobin-related protein. Science. 1995 Apr 14; 268(5208):284-6. PMID: 7716520.
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    203. Sarkar AK, Fritz TA, Taylor WH, Esko JD. Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1-->4GlcNAc beta-O-naphthalenemethanol. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3323-7. PMID: 7724561.
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    204. Miao HQ, Fritz TA, Esko JD, Zimmermann J, Yayon A, Vlodavsky I. Heparan sulfate primed on beta-D-xylosides restores binding of basic fibroblast growth factor. J Cell Biochem. 1995 Feb; 57(2):173-84. PMID: 7759555.
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    205. Tytler EM, Moore DR, Pierce MA, Hager KM, Esko JD, Hajduk SL. Reconstitution of the trypanolytic factor from components of a subspecies of human high-density lipoproteins. Mol Biochem Parasitol. 1995 Jan; 69(1):9-17. PMID: 7723792.
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    206. Fritz TA, Gabb MM, Wei G, Esko JD. Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate. J Biol Chem. 1994 Nov 18; 269(46):28809-14. PMID: 7961837.
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    207. Bame KJ, Zhang L, David G, Esko JD. Sulphated and undersulphated heparan sulphate proteoglycans in a Chinese hamster ovary cell mutant defective in N-sulphotransferase. Biochem J. 1994 Oct 01; 303 ( Pt 1):81-7. PMID: 7945269.
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    208. Zhang L, Esko JD. Amino acid determinants that drive heparan sulfate assembly in a proteoglycan. J Biol Chem. 1994 Jul 29; 269(30):19295-9. PMID: 8034692.
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    209. Hager KM, Pierce MA, Moore DR, Tytler EM, Esko JD, Hajduk SL. Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes. J Cell Biol. 1994 Jul; 126(1):155-67. PMID: 8027174.
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    210. Fritz TA, Lugemwa FN, Sarkar AK, Esko JD. Biosynthesis of heparan sulfate on beta-D-xylosides depends on aglycone structure. J Biol Chem. 1994 Jan 07; 269(1):300-7. PMID: 8276811.
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    211. Hajduk SL, Hager KM, Esko JD. Human high density lipoprotein killing of African trypanosomes. Annu Rev Microbiol. 1994; 48:139-62. PMID: 7826003.
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    212. Bar-Shavit R, Eskohjido Y, Fenton JW, Esko JD, Vlodavsky I. Thrombin adhesive properties: induction by plasmin and heparan sulfate. J Cell Biol. 1993 Dec; 123(5):1279-87. PMID: 8245131.
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    213. Rostand KS, Esko JD. Cholesterol and cholesterol esters: host receptors for Pseudomonas aeruginosa adherence. J Biol Chem. 1993 Nov 15; 268(32):24053-9. PMID: 8226950.
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    214. Love DC, Esko JD, Mosser DM. A heparin-binding activity on Leishmania amastigotes which mediates adhesion to cellular proteoglycans. J Cell Biol. 1993 Nov; 123(3):759-66. PMID: 8227137.
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    215. Lugemwa FN, Esko JD. Synthesis of beta-estradiol beta-D-xylopyranosides, primers of heparan sulfate in Chinese hamster ovary cells. Carbohydr Res. 1993 Feb 01; 239:285-90. PMID: 8457998.
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    216. Montgomery RI, Lidholt K, Flay NW, Liang J, Vertel B, Lindahl U, Esko JD. Stable heparin-producing cell lines derived from the Furth murine mastocytoma. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11327-31. PMID: 1454815.
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    217. Neyts J, Snoeck R, Schols D, Balzarini J, Esko JD, Van Schepdael A, De Clercq E. Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate. Virology. 1992 Jul; 189(1):48-58. PMID: 1376540.
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    218. Lidholt K, Weinke JL, Kiser CS, Lugemwa FN, Bame KJ, Cheifetz S, Massagué J, Lindahl U, Esko JD. A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2267-71. PMID: 1532254.
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    219. Hajduk SL, Hager K, Esko JD. High-density lipoprotein-mediated lysis of trypanosomes. Parasitol Today. 1992 Mar; 8(3):95-8. PMID: 15463583.
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    220. Shieh MT, WuDunn D, Montgomery RI, Esko JD, Spear PG. Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans. J Cell Biol. 1992 Mar; 116(5):1273-81. PMID: 1310996.
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    221. Esko JD. Animal cell mutants defective in heparan sulfate polymerization. Adv Exp Med Biol. 1992; 313:97-106. PMID: 1442273.
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    222. Esko JD. Genetic analysis of proteoglycan structure, function and metabolism. Curr Opin Cell Biol. 1991 Oct; 3(5):805-16. PMID: 1931081.
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    223. Bame KJ, Reddy RV, Esko JD. Coupling of N-deacetylation and N-sulfation in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase. J Biol Chem. 1991 Jul 05; 266(19):12461-8. PMID: 2061321.
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    224. Bame KJ, Lidholt K, Lindahl U, Esko JD. Biosynthesis of heparan sulfate. Coordination of polymer-modification reactions in a Chinese hamster ovary cell mutant defective in N-sulfotransferase. J Biol Chem. 1991 Jun 05; 266(16):10287-93. PMID: 2037581.
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    225. Lugemwa FN, Esko JD. Estradiol beta-D-xyloside, an efficient primer for heparan sulfate biosynthesis. J Biol Chem. 1991 Apr 15; 266(11):6674-7. PMID: 2016281.
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    226. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991 Feb 22; 64(4):841-8. PMID: 1847668.
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    227. Esko JD, Montgomery RI, Lindahl U. Secretory heparin in murine mastocytoma cell lines. Biochem Soc Trans. 1990 Oct; 18(5):807-9. PMID: 2128061.
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    228. LeBaron RG, Höök A, Esko JD, Gay S, Höök M. Binding of heparan sulfate to type V collagen. A mechanism of cell-substrate adhesion. J Biol Chem. 1989 May 15; 264(14):7950-6. PMID: 2524477.
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    229. Bame KJ, Esko JD. Undersulfated heparan sulfate in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase. J Biol Chem. 1989 May 15; 264(14):8059-65. PMID: 2524478.
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    230. Hajduk SL, Moore DR, Vasudevacharya J, Siqueira H, Torri AF, Tytler EM, Esko JD. Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein. J Biol Chem. 1989 Mar 25; 264(9):5210-7. PMID: 2494183.
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    231. Kaesberg PR, Ershler WB, Esko JD, Mosher DF. Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan. J Clin Invest. 1989 Mar; 83(3):994-1001. PMID: 2522106.
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    232. Esko JD. Replica plating of animal cells. Methods Cell Biol. 1989; 32:387-422. PMID: 2691858.
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    233. Elgavish A, Esko JD, Knurr A. Chinese hamster ovary cell mutants deficient in an anion exchanger functionally similar to the erythroid band 3. J Biol Chem. 1988 Dec 15; 263(35):18607-13. PMID: 3198592.
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    234. Esko JD, Rostand KS, Weinke JL. Tumor formation dependent on proteoglycan biosynthesis. Science. 1988 Aug 26; 241(4869):1092-6. PMID: 3137658.
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    235. Murphy-Ullrich JE, Westrick LG, Esko JD, Mosher DF. Altered metabolism of thrombospondin by Chinese hamster ovary cells defective in glycosaminoglycan synthesis. J Biol Chem. 1988 May 05; 263(13):6400-6. PMID: 3129423.
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    236. LeBaron RG, Esko JD, Woods A, Johansson S, Höök M. Adhesion of glycosaminoglycan-deficient chinese hamster ovary cell mutants to fibronectin substrata. J Cell Biol. 1988 Mar; 106(3):945-52. PMID: 3346331.
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    237. Esko JD, Weinke JL, Taylor WH, Ekborg G, Rodén L, Anantharamaiah G, Gawish A. Inhibition of chondroitin and heparan sulfate biosynthesis in Chinese hamster ovary cell mutants defective in galactosyltransferase I. J Biol Chem. 1987 Sep 05; 262(25):12189-95. PMID: 2957376.
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    238. Ludwigs U, Elgavish A, Esko JD, Meezan E, Rodén L. Reaction of unsaturated uronic acid residues with mercuric salts. Cleavage of the hyaluronic acid disaccharide 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose. Biochem J. 1987 Aug 01; 245(3):795-804. PMID: 3663191.
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    239. Esko JD, Elgavish A, Prasthofer T, Taylor WH, Weinke JL. Sulfate transport-deficient mutants of Chinese hamster ovary cells. Sulfation of glycosaminoglycans dependent on cysteine. J Biol Chem. 1986 Nov 25; 261(33):15725-33. PMID: 3782085.
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    240. Esko JD. Detection of animal cell LDL mutants by replica plating. Methods Enzymol. 1986; 129:237-53. PMID: 3523146.
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    241. Esko JD, Stewart TE, Taylor WH. Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 1985 May; 82(10):3197-201. PMID: 3858816.
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    242. Esko JD, Matsuoka KY. Biosynthesis of phosphatidylcholine from serum phospholipids in Chinese hamster ovary cells deprived of choline. J Biol Chem. 1983 Mar 10; 258(5):3051-7. PMID: 6826551.
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    243. Hirschberg CB, Perez M, Snider M, Hanneman WL, Esko J, Raetz CR. Autoradiographic detection and characterization of a Chinese hamster ovary cell mutant deficient in fucoproteins. J Cell Physiol. 1982 Jun; 111(3):255-63. PMID: 6284769.
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    244. Raetz CR, Wermuth MM, McIntyre TM, Esko JD, Wing DC. Somatic cell cloning in polyester stacks. Proc Natl Acad Sci U S A. 1982 May; 79(10):3223-7. PMID: 6954474.
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    245. Esko JD, Nishijima M, Raetz CR. Animal cells dependent on exogenous phosphatidylcholine for membrane biogenesis. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1698-702. PMID: 6281780.
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    246. Antti V, Jukka M, Jukka S, Reijo A, Esko J. Contact lens induced transient changes in corneal endothelium. Acta Ophthalmol (Copenh). 1981 Aug; 59(4):552-9. PMID: 7315212.
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    247. Esko JD, Wermuth MM, Raetz CR. Thermolabile CDP-choline synthetase in an animal cell mutant defective in lecithin formation. J Biol Chem. 1981 Jul 25; 256(14):7388-93. PMID: 6265447.
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    248. Esko JD, Raetz CR. Autoradiographic detection of animal cell membrane mutants altered in phosphatidylcholine synthesis. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5192-6. PMID: 6254065.
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    249. Esko JD, Raetz CR. Mutants of Chinese hamster ovary cells with altered membrane phospholipid composition. Replacement of phosphatidylinositol by phosphatidylglycerol in a myo-inositol auxotroph. J Biol Chem. 1980 May 25; 255(10):4474-80. PMID: 7372588.
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    250. Esko JD, Raetz CR. Replica plating and in situ enzymatic assay of animal cell colonies established on filter paper. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1190-3. PMID: 349559.
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    251. Esko JD, Gilmore JR, Glaser M. Use of a fluorescent probe to determine the viscosity of LM cell membranes with altered phospholipid compositions. Biochemistry. 1977 May 03; 16(9):1881-90. PMID: 192276.
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    252. Engelhard VH, Esko JD, Storm DR, Glaser M. Modification of adenylate cyclase activity in LM cells by manipulation of the membrane phospholipid composition in vivo. Proc Natl Acad Sci U S A. 1976 Dec; 73(12):4482-6. PMID: 1069999.
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