Xin Sun
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Title(s) | Professor, Pediatrics |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0766 La Jolla CA 92093
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Phone | 858-246-2000 |
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vCard | Download vCard |
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Biography UCSF | Postdoc | 04/2002 | Developmental Genetics | Yale University | Ph.D. | 02/1997 | Developmental Biology |
Overview Research focus: The building of an organ starts from an amorphous cluster of cells, and proceeds following an elaborate blueprint of coordinated proliferation, morphogenesis and differentiation. Organ function relies on the harmonization with other organs, the infusion by blood and immune cells, and the wiring by the nervous system. We employ cutting edge techniques in modern biology, including genome editing, genomics, epigenomics, imaging and disease modeling, to delineate the robustness that dictates normal organ function, and uncover the imperfection that initiates pathogenesis.
At the center of our investigation is the lung, an organ that is vital at first breath. It is the setting for many fetal, pediatric and adult diseases that have little explanation and no cure. We use disease modeling as a starting point for basic discoveries in developmental biology, stem cell biology and neural-immune interface with physiology.
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Single cell multiomic profiling of human lung reveals cell type-specific and age-dynamic control of SARS-CoV2 host genes. Elife. 2020 Nov 09; 9.
Wang A, Chiou J, Poirion OB, Buchanan J, Valdez MJ, Verheyden JM, Hou X, Kudtarkar P, Narendra S, Newsome JM, Guo M, Faddah DA, Zhang K, Young RE, Barr J, Sajti E, Misra R, Huyck H, Rogers L, Poole C, Whitsett JA, Pryhuber G, Xu Y, Gaulton KJ, Preissl S, Sun X. PMID: 33164753.
View in: PubMed Mentions: 1 Fields: Translation: HumansCellsPHPublic Health
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Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung. Dev Cell. 2020 Oct 26; 55(2):123-132.
Xu J, Yu H, Sun X. PMID: 33108755.
View in: PubMed Mentions: Fields:
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A transitional stem cell state in the lung. Nat Cell Biol. 2020 09; 22(9):1025-1026.
Verheyden JM, Sun X. PMID: 32778743.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface. J Clin Invest. 2020 Jun 01; 130(6):2859-2871.
Li R, Li X, Hagood J, Zhu MS, Sun X. PMID: 32338642.
View in: PubMed Mentions: Fields:
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Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell. 2020 04 06; 53(1):73-85.e5.
Young RE, Jones MK, Hines EA, Li R, Luo Y, Shi W, Verheyden JM, Sun X. PMID: 32142630.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Wheeze No More: Growing Out of Your Dopaminergic Nerves. Immunity. 2019 12 17; 51(6):977-979.
Barr J, Su Y, Sun X. PMID: 31851903.
View in: PubMed Mentions: Fields: Translation: Humans
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E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size. Development. 2019 12 16; 146(24).
Sui P, Li R, Zhang Y, Tan C, Garg A, Verheyden JM, Sun X. PMID: 31767619.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells. Curr Top Dev Biol. 2019; 132:67-89.
Garg A, Sui P, Verheyden JM, Young LR, Sun X. PMID: 30797518.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response. Elife. 2018 09 04; 7.
Li R, Bernau K, Sandbo N, Gu J, Preissl S, Sun X. PMID: 30178747.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Pulmonary neuroendocrine cells amplify allergic asthma responses. Science. 2018 06 08; 360(6393).
Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. PMID: 29599193.
View in: PubMed Mentions: 36 Fields: Translation: HumansAnimalsCells
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FGF receptors control alveolar elastogenesis. Development. 2017 12 15; 144(24):4563-4572.
Li R, Herriges JC, Chen L, Mecham RP, Sun X. PMID: 29122839.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Brief Report: Changes in Levels of Inflammation After Antiretroviral Treatment During Early HIV Infection in AIDS Clinical Trials Group Study A5217. . 2017 05 01; 75(1):137-141.
Macatangay BJ, Yang M, Sun X, Morton J, De Gruttola V, Little S, Hogan C, Rinaldo CR. PMID: 28198712.
View in: PubMed Mentions:
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TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 10 27; 538(7626):528-532.
Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL. PMID: 27760115.
View in: PubMed Mentions: 35 Fields: Translation: AnimalsCells
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E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7557-62.
Zhang Y, Yokoyama S, Herriges JC, Zhang Z, Young RE, Verheyden JM, Sun X. PMID: 27335464.
View in: PubMed Mentions: 7 Fields: Translation: Animals
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Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis. Dev Dyn. 2016 Apr; 245(4):497-507.
Hines EA, Verheyden JM, Lashua AJ, Larson SC, Branchfield K, Domyan ET, Gao J, Harvey JF, Herriges JC, Hu L, Mcculley DJ, Throckmorton K, Yokoyama S, Ikeda A, Xu G, Sun X. PMID: 26813283.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimals
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Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12; 351(6274):707-10.
Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X. PMID: 26743624.
View in: PubMed Mentions: 41 Fields: Translation: AnimalsCells
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A three-dimensional study of alveologenesis in mouse lung. Dev Biol. 2016 Jan 15; 409(2):429-41.
Branchfield K, Li R, Lungova V, Verheyden JM, McCulley D, Sun X. PMID: 26632490.
View in: PubMed Mentions: 38 Fields: Translation: AnimalsCells
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FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell. 2015 Nov 09; 35(3):322-32.
Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X. PMID: 26555052.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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In vitro model alveoli from photodegradable microsphere templates. Biomater Sci. 2015 Jun; 3(6):821-32.
Lewis KJ, Tibbitt MW, Zhao Y, Branchfield K, Sun X, Balasubramaniam V, Anseth KS. PMID: 26221842.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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The pulmonary mesenchyme directs lung development. Curr Opin Genet Dev. 2015 Jun; 32:98-105.
McCulley D, Wienhold M, Sun X. PMID: 25796078.
View in: PubMed Mentions: 42 Fields: Translation: HumansAnimals
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Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15; 399(2):263-82.
Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL. PMID: 25601450.
View in: PubMed Mentions: 7 Fields: Translation: Animals
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Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction. PLoS One. 2014; 9(12):e112997.
Hines EA, Szakaly RJ, Leng N, Webster AT, Verheyden JM, Lashua AJ, Kendziorski C, Rosenthal LA, Gern JE, Sorkness RL, Sun X, Lemanske RF. PMID: 25437859.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Tissue crosstalk in lung development. J Cell Biochem. 2014 Sep; 115(9):1469-77.
Hines EA, Sun X. PMID: 24644090.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimals
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The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation. J Allergy Clin Immunol. 2014 Jul; 134(1):204-14.
Pham D, Sehra S, Sun X, Kaplan MH. PMID: 24486067.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19444-9.
Hines EA, Jones MK, Verheyden JM, Harvey JF, Sun X. PMID: 24218621.
View in: PubMed Mentions: 14 Fields: Translation: Animals
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Viral bronchiolitis in young rats causes small airway lesions that correlate with reduced lung function. Am J Respir Cell Mol Biol. 2013 Nov; 49(5):808-13.
Sorkness RL, Szakaly RJ, Rosenthal LA, Sullivan R, Gern JE, Lemanske RF, Sun X. PMID: 23763491.
View in: PubMed Mentions: 5 Fields: Translation: Animals
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Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6.
Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. PMID: 23607856.
View in: PubMed Mentions: 28 Fields: Translation: Humans
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Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol. 2013 Apr 15; 376(2):125-35.
Mehta V, Schmitz CT, Keil KP, Joshi PS, Abler LL, Lin TM, Taketo MM, Sun X, Vezina CM. PMID: 23396188.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14; 24(1):52-63.
Domyan ET, Branchfield K, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X. PMID: 23328398.
View in: PubMed Mentions: 22 Fields: Translation: Animals
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The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012; 7(10):e47358.
Du Y, Liu B, Guo F, Xu G, Ding Y, Liu Y, Sun X, Xu G. PMID: 23077600.
View in: PubMed Mentions: 12 Fields: Translation: Animals
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Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep; 241(9):1432-53.
Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X. PMID: 22711520.
View in: PubMed Mentions: 16 Fields: Translation: Animals
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Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med. 2011 May; 17(5):627-32.
Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE. PMID: 21483405.
View in: PubMed Mentions: 82 Fields: Translation: HumansCells
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Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development. 2011 Mar; 138(5):971-81.
Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X. PMID: 21303850.
View in: PubMed Mentions: 68 Fields: Translation: Animals
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The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15; 351(2):254-65.
Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X. PMID: 21256124.
View in: PubMed Mentions: 12 Fields: Translation: Animals
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Patterning and plasticity in development of the respiratory lineage. Dev Dyn. 2011 Mar; 240(3):477-85.
Domyan ET, Sun X. PMID: 21337460.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimals
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Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development. 2010 Oct; 137(20):3417-26.
Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen YT, Behringer RR, Sun X. PMID: 20826535.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16287-92.
Harris-Johnson KS, Domyan ET, Vezina CM, Sun X. PMID: 19805295.
View in: PubMed Mentions: 90 Fields: Translation: AnimalsCells
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Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn. 2009 Aug; 238(8):1999-2013.
Abler LL, Mansour SL, Sun X. PMID: 19618463.
View in: PubMed Mentions: 60 Fields: Translation: AnimalsCells
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FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009 Apr; 16(4):607-13.
Zhang Z, Verheyden JM, Hassell JA, Sun X. PMID: 19386269.
View in: PubMed Mentions: 70 Fields: Translation: HumansAnimalsCells
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Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet. 2009 May 15; 18(10):1740-54.
Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT. PMID: 19286674.
View in: PubMed Mentions: 43 Fields: Translation: HumansAnimalsCells
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Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn. 2009 Jan; 238(1):123-37.
Yi L, Domyan ET, Lewandoski M, Sun X. PMID: 19097117.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature. 2008 Jul 31; 454(7204):638-41.
Verheyden JM, Sun X. PMID: 18594511.
View in: PubMed Mentions: 65 Fields: Translation: AnimalsCells
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Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2208-13.
Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X. PMID: 16452165.
View in: PubMed Mentions: 188 Fields: Translation: AnimalsCells
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Emerging from the fog: hypotheses and paradigms in developmental biology--the Society for Developmental Biology 2005 Annual Meeting Report. Dev Biol. 2006 Jan 15; 289(2):273-82.
Sun X, Barolo S, Bilder D, Montgomery M, Sinha N. PMID: 16337185.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development. 2005 Oct; 132(19):4235-45.
Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X. PMID: 16120640.
View in: PubMed Mentions: 39 Fields: Translation: Animals
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Year | Publications |
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2005 | 2 | 2006 | 1 | 2008 | 1 | 2009 | 5 | 2010 | 2 | 2011 | 3 | 2012 | 2 | 2013 | 5 | 2014 | 3 | 2015 | 5 | 2016 | 4 | 2017 | 2 | 2018 | 2 | 2019 | 3 | 2020 | 5 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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