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David Smith

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0679
La Jolla CA 92093
Phone858-642-1620
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego School of Medicine, La Jolla, CAM.A.S. Clinical Research2005Infectious Diseases
    University of California, San Diego School of Medicine, La Jolla, CAFellow2003Infectious Diseases
    University of California, San Diego School of Medicine, La Jolla, CAChief Resident2000Internal Medicine
    University of California, San Diego School of Medicine, La Jolla, CAIntern and Resident1999Internal Medicine
    East Tennessee State University College of Medicine, Johnson City, TNM.D.1996Medicine
    University of Tennessee at Chattanooga, Chattanooga, TNB.S. summa cum laude1992Biology
    Collapse Awards and Honors
    East Tennessee State University1995AOA
    East Tennessee State University1996Dean Scholarship Award
    San Diego LGBT Center2001Men’s Volunteer of the Year
    San Diego LGBT Center2005Transgender Community Award
    San Diego Metropolitan Magazine200840 under 40
    County of San Diego2009Dr. Truax Award for HIV Service
    National Institute for Drug Abuse2012Avant Garde Award for HIV
    American College of Physicians2014Fellow
    American Society of Clinical Investigation2015Fellow

    Collapse Overview 
    Collapse Overview
    Dr. Davey Smith is a translational research virologist. He uses basic science techniques to answer clinically relevant questions and vice-versa. He works both at the UCSD Antiviral Research Center and in his laboratory on the UCSD campus, where he performs bench research . His primary research focus is on the transmission of HIV, including HIV superinfection, molecular epidemiology and characterizing HIV shed from the genital tract. He also investigates the virologic correlates of end organ damage, like neuropathology, both domestically and abroad. These studies are in pursuit to understand the drivers of HIV transmission and disease and find new ways to interrupt them.

    Dr. Smith graduated from East Tennessee State University School of Medicine. He did his internship, residency and chief residency in Internal Medicine at University of California San Diego, and then he stayed at UCSD to complete his fellowship in Infectious Diseases. He joined UCSD faculty in 2003. He became Professor of Medicine in 2013, Co-Director of San Diego CFAR in 2013, Vice-Chair of Faculty in 2016 and Head of the UCSD Division of Infectious Diseases and Global Public Health in 2017.


    Collapse Research 
    Collapse Research Activities and Funding
    Revealing Reservoirs during Rebound (R3)
    NIH/NIAID P01AI131385Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Perturbing the HIV Reservoir with Immune Stimulation
    NIH/NIAID R01AI118422Feb 1, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Characterizing proviral populations in brain tissues
    NIH/NIDA R21DA041007Sep 15, 2015 - Jul 31, 2018
    Role: Principal Investigator
    High-throughput Deep Sequencing Assay to Reliably Measure the HIV Reservoir during Antiretroviral Therapy
    NIH/NIAID R01AI120009Jul 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Combined Testing to Identify Virologic Failure and HIV-1 Drug Resistance
    NIH/NIBIB R03EB015365Sep 30, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Molecular Epidemiology for HIV Prevention for Drug Users and Other Risk Groups
    NIH/NIDA DP1DA034978Aug 1, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Mentoring Translational Research in HIV
    NIH/NIAID K24AI100665May 1, 2012 - Apr 30, 2022
    Role: Principal Investigator
    Effects of Host and Viral Aging on Neurocognition
    NIH/NIMH R01MH097520Mar 5, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Pooled Nucleic Acid Testing to Identify Antiretroviral Treatment Failure in India
    NIH/NIAID R21AI080353Apr 1, 2011 - Sep 30, 2013
    Role: Principal Investigator
    Interplay of B cells and HIV Leading to Broad Neutralizing Antibody Responses
    NIH U19AI090970Sep 1, 2010 - Aug 31, 2015
    Role: Co-Investigator
    A Multi-Site Investigation into the Effect of HIV Clade on Neurocognition
    NIH/NIMH R01MH083552Sep 8, 2008 - Aug 31, 2014
    Role: Principal Investigator
    Detection and Characterization of HIV-1 Intraclade Dual Infection
    NIH/NIAID R21AI077304Mar 1, 2008 - Feb 28, 2011
    Role: Principal Investigator
    Compartmentalization of HIV within the genital tract
    NIH/NIAID K23AI055276Jul 1, 2003 - Apr 30, 2008
    Role: Principal Investigator
    HIV Neurobehavioral Research Center
    NIH/NIMH P30MH062512Apr 24, 2001 - Feb 28, 2021
    Role: Co-Investigator
    Center for AIDS Research
    NIH/NIAID P30AI036214Apr 1, 1994 - Mar 31, 2023
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Xu M, Moresco JJ, Chang M, Mukim A, Smith D, Diedrich JK, Yates JR, Jones KA. SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy. PLoS Pathog. 2018 05; 14(5):e1007071. PMID: 29791506.
      View in: PubMed
    2. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith D, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2018 Apr 17; 48(4):831-832. PMID: 29669254.
      View in: PubMed
    3. Gianella S, Sonya Haw J, Blumenthal J, Sullivan B, Smith D. The Importance of Human Immunodeficiency Virus Research for Transgender and Gender-Nonbinary Individuals. Clin Infect Dis. 2018 Apr 17; 66(9):1460-1466. PMID: 29126186.
      View in: PubMed
    4. Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith D, Little SJ, Lauffenburger DA, Richman DD, Alter G. Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors. AIDS. 2018 Feb 20; 32(4):443-450. PMID: 29239894.
      View in: PubMed
    5. Mehta SR, Chaillon A, Gaines TL, Gonzalez-Zuniga PE, Stockman JK, Almanza-Reyes H, Chavez JR, Vera A, Wagner KD, Patterson TL, Scott B, Smith D, Strathdee SA. Impact of Public Safety Policies on Human Immunodeficiency Virus Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis. 2018 Feb 10; 66(5):758-764. PMID: 29045592.
      View in: PubMed
    6. Chaillon A, Gianella S, Lada SM, Perez-Santiago J, Jordan P, Ignacio C, Karris M, Richman DD, Mehta SR, Little SJ, Wertheim JO, Smith D. Size, Composition, and Evolution of HIV DNA Populations during Early Antiretroviral Therapy and Intensification with Maraviroc. J Virol. 2018 Feb 01; 92(3). PMID: 29142136.
      View in: PubMed
    7. Dinesha TR, Boobalan J, Sivamalar S, Solomon SS, Poongulali S, Pradeep A, Murugavel KG, Balakrishnan P, Smith D, Saravanan S. HIV, Hepatitis B Virus, and Hepatitis C Virus Prevalence Among High-Risk Populations in South India. AIDS Res Hum Retroviruses. 2018 Apr; 34(4):327-328. PMID: 29161880.
      View in: PubMed
    8. Salas-Espinoza KJ, Menchaca-Diaz R, Patterson TL, Urada LA, Smith D, Strathdee SA, Pitpitan EV. HIV Prevalence and Risk Behaviors in Male to Female (MTF) Transgender Persons in Tijuana, Mexico. AIDS Behav. 2017 Dec; 21(12):3271-3278. PMID: 29032411.
      View in: PubMed
    9. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith D, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017 11 21; 47(5):875-889.e10. PMID: 29166588.
      View in: PubMed
    10. Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith D, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, Wrin T, Algate P, Chan-Hui PY, Karita E. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity. 2017 11 21; 47(5):990-1003.e9. PMID: 29166592.
      View in: PubMed
    11. Chaillon A, Nakazawa M, Wertheim JO, Little SJ, Smith D, Mehta SR, Gianella S. No Substantial Evidence for Sexual Transmission of Minority HIV Drug Resistance Mutations in Men Who Have Sex with Men. J Virol. 2017 11 01; 91(21). PMID: 28794047.
      View in: PubMed
    12. Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith D, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T. Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. Antimicrob Agents Chemother. 2017 Oct; 61(10). PMID: 28807909.
      View in: PubMed
    13. Wagner GA, Landais E, Caballero G, Phung P, Kosakovsky Pond SL, Poignard P, Richman DD, Little SJ, Smith D. Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response. J Virol. 2017 09 01; 91(17). PMID: 28615205.
      View in: PubMed
    14. Oom AL, Smith D, Akrami K. Identification of putative unique immunogenic ZIKV and DENV1-4 peptides for diagnostic cellular based tests. Sci Rep. 2017 Jul 24; 7(1):6218. PMID: 28740150.
      View in: PubMed
    15. Vesa J, Chaillon A, Wagner GA, Anderson CM, Richman DD, Smith D, Little SJ. Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles. AIDS. 2017 May 15; 31(8):1149-1158. PMID: 28244954.
      View in: PubMed
    16. Choi JY, Pond SLK, Anderson CM, Richman DD, Smith D. Molecular Features of the V1-V4 Coding Region of Sexually Transmitted Human Immunodeficiency Virus Type 1. J Infect Dis. 2017 May 15; 215(10):1506-1513. PMID: 28419276.
      View in: PubMed
    17. Ahn MY, Wertheim JO, Kim WJ, Kim SW, Lee JS, Ann HW, Jeon Y, Ahn JY, Song JE, Oh DH, Kim YC, Kim EJ, Jung IY, Kim MH, Jeong W, Jeong SJ, Ku NS, Kim JM, Smith D, Choi JY. Short Communication: HIV-1 Transmission Networks Across South Korea. AIDS Res Hum Retroviruses. 2017 Aug; 33(8):827-831. PMID: 28346838.
      View in: PubMed
    18. de Almeida SM, Rotta I, Ribeiro CE, Oliveira MF, Chaillon A, de Pereira AP, Cunha AP, Zonta M, Bents JF, Raboni SM, Smith D, Letendre S, Ellis RJ. Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization-case study. J Neurovirol. 2017 Jun; 23(3):460-473. PMID: 28247269.
      View in: PubMed
    19. Chaillon A, Essat A, Frange P, Smith D, Delaugerre C, Barin F, Ghosn J, Pialoux G, Robineau O, Rouzioux C, Goujard C, Meyer L, Chaix ML. Spatiotemporal dynamics of HIV-1 transmission in France (1999-2014) and impact of targeted prevention strategies. Retrovirology. 2017 Feb 21; 14(1):15. PMID: 28222757.
      View in: PubMed
    20. Morris SR, Zhao M, Smith D, Vargas MV, Little SJ, Gianella S. Longitudinal Viral Dynamics in Semen During Early HIV Infection. Clin Infect Dis. 2017 02 15; 64(4):428-434. PMID: 28174909.
      View in: PubMed
    21. Glinka ER, Smith D, Johns ST. Now is the Time to Study the Timing of Influenza Vaccine. HIV Med. 2018 Mar; 19(3):e53. PMID: 28116796.
      View in: PubMed
    22. Green N, Hoenigl M, Chaillon A, Anderson CM, Kosakovsky Pond SL, Smith D, Little SJ. Partner services in adults with acute and early HIV infection. AIDS. 2017 Jan 14; 31(2):287-293. PMID: 27831950.
      View in: PubMed
    23. Wertheim JO, Kosakovsky Pond SL, Forgione LA, Mehta SR, Murrell B, Shah S, Smith D, Scheffler K, Torian LV. Social and Genetic Networks of HIV-1 Transmission in New York City. PLoS Pathog. 2017 Jan; 13(1):e1006000. PMID: 28068413.
      View in: PubMed
    24. Oliveira MF, Chaillon A, Nakazawa M, Vargas M, Letendre SL, Strain MC, Ellis RJ, Morris S, Little SJ, Smith D, Gianella S. Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations. PLoS Pathog. 2017 Jan; 13(1):e1006112. PMID: 28046096.
      View in: PubMed
    25. Gianella S, Taylor J, Brown TR, Kaytes A, Achim CL, Moore DJ, Little SJ, Ellis RJ, Smith D. Can research at the end of life be a useful tool to advance HIV cure? AIDS. 2017 Jan 02; 31(1):1-4. PMID: 27755112.
      View in: PubMed
    26. Chaillon A, Smith D, Vanpouille C, Lisco A, Jordan P, Caballero G, Vargas M, Gianella S, Mehta SR. HIV Trafficking Between Blood and Semen During Early Untreated HIV Infection. J Acquir Immune Defic Syndr. 2017 01 01; 74(1):95-102. PMID: 27548440.
      View in: PubMed
    27. Saravanan S, Kausalya B, Gomathi S, Sivamalar S, Pachamuthu B, Selvamuthu P, Pradeep A, Sunil S, Mothi SN, Smith D, Kantor R. Etravirine and Rilpivirine Drug Resistance Among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India. AIDS Res Hum Retroviruses. 2017 06; 33(6):567-574. PMID: 27869478.
      View in: PubMed
    28. Hu Y, Wan Z, Zhou YH, Smith D, Zheng YT, Zhang C. Identification of Two New HIV-1 Circulating Recombinant Forms (CRF87_cpx and CRF88_BC) from Reported Unique Recombinant Forms in Asia. AIDS Res Hum Retroviruses. 2017 04; 33(4):353-358. PMID: 27762598.
      View in: PubMed
    29. Wagner GA, Chaillon A, Liu S, Franklin DR, Caballero G, Kosakovsky Pond SL, Vaida F, Heaton RK, Letendre SL, Grant I, Richman DD, Smith D. HIV-associated neurocognitive disorder is associated with HIV-1 dual infection. AIDS. 2016 Nov 13; 30(17):2591-2597. PMID: 27536983.
      View in: PubMed
    30. de Almeida SM, Rotta I, Ribeiro CE, Smith D, Wang R, Judicello J, Potter M, Vaida F, Letendre S, Ellis RJ. Blood-CSF barrier and compartmentalization of CNS cellular immune response in HIV infection. J Neuroimmunol. 2016 Dec 15; 301:41-48. PMID: 27836178.
      View in: PubMed
    31. Karris MY, Umlauf A, Vaida F, Richman D, Little S, Smith D. A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore). 2016 Nov; 95(44):e5315. PMID: 27858912.
      View in: PubMed
    32. Bharti AR, McCutchan A, Deutsch R, Smith D, Ellis RJ, Cherner M, Woods SP, Heaton RK, Grant I, Letendre SL. Latent Toxoplasma Infection and Higher Toxoplasma gondii Immunoglobulin G Levels Are Associated With Worse Neurocognitive Functioning in HIV-Infected Adults. Clin Infect Dis. 2016 Dec 15; 63(12):1655-1660. PMID: 27794019.
      View in: PubMed
    33. Hoenigl M, Pérez-Santiago J, Nakazawa M, de Oliveira MF, Zhang Y, Finkelman MA, Letendre S, Smith D, Gianella S. (1?3)-ß-d-Glucan: A Biomarker for Microbial Translocation in Individuals with Acute or Early HIV Infection? Front Immunol. 2016; 7:404. PMID: 27752257.
      View in: PubMed
    34. Yek C, Gianella S, Plana M, Castro P, Scheffler K, García F, Massanella M, Smith D. Standard vaccines increase HIV-1 transcription during antiretroviral therapy. AIDS. 2016 Sep 24; 30(15):2289-98. PMID: 27427877.
      View in: PubMed
    35. Smith D, Nakazawa M, Freeman ML, Anderson CM, Oliveira MF, Little SJ, Gianella S. Asymptomatic CMV Replication During Early Human Immunodeficiency Virus (HIV) Infection Is Associated With Lower CD4/CD8 Ratio During HIV Treatment. Clin Infect Dis. 2016 Dec 01; 63(11):1517-1524. PMID: 27601222.
      View in: PubMed
    36. Chen X, Ye M, Duo L, Pang W, Smith D, Zhang C, Zheng YT. First description of two new HIV-1 recombinant forms CRF82_cpx and CRF83_cpx among drug users in Northern Myanmar. Virulence. 2017 07 04; 8(5):497-503. PMID: 27574950.
      View in: PubMed
    37. Chen X, Ye M, Pang W, Smith D, Zhang C, Zheng YT. First Appearance of HIV-1 CRF07_BC and CRF08_BC Outside China. AIDS Res Hum Retroviruses. 2017 01; 33(1):74-76. PMID: 27392826.
      View in: PubMed
    38. Hoenigl M, Chaillon A, Mehta SR, Smith D, Graff-Zivin J, Little SJ. Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions. J Infect. 2016 Nov; 73(5):476-484. PMID: 27521468.
      View in: PubMed
    39. Gianella S, Kosakovsky Pond SL, Oliveira MF, Scheffler K, Strain MC, De la Torre A, Letendre S, Smith D, Ellis RJ. Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy. Virus Evol. 2016 Jul; 2(2):vew020. PMID: 27774305.
      View in: PubMed
    40. Günthard HF, Saag MS, Benson CA, del Rio C, Eron JJ, Gallant JE, Hoy JF, Mugavero MJ, Sax PE, Thompson MA, Gandhi RT, Landovitz RJ, Smith D, Jacobsen DM, Volberding PA. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2016 Jul 12; 316(2):191-210. PMID: 27404187; PMCID: PMC5012643.
    41. de Almeida SM, Rotta I, Jiang Y, Li X, Raboni SM, Ribeiro CE, Smith D, Potter M, Vaida F, Letendre S, Ellis RJ. Biomarkers of chemotaxis and inflammation in cerebrospinal fluid and serum in individuals with HIV-1 subtype C versus B. J Neurovirol. 2016 12; 22(6):715-724. PMID: 27400932.
      View in: PubMed
    42. Laird Smith M, Murrell B, Eren K, Ignacio C, Landais E, Weaver S, Phung P, Ludka C, Hepler L, Caballero G, Pollner T, Guo Y, Richman D. Rapid Sequencing of Complete env Genes from Primary HIV-1 Samples. Virus Evol. 2016 Jul; 2(2):vew018. PMID: 29492273.
      View in: PubMed
    43. Zhao J, Chen L, Chaillon A, Zheng C, Cai W, Yang Z, Li G, Gan Y, Wang X, Hu Y, Zhong P, Zhang C, Smith D. The dynamics of the HIV epidemic among men who have sex with men (MSM) from 2005 to 2012 in Shenzhen, China. Sci Rep. 2016 06 29; 6:28703. PMID: 27352965.
      View in: PubMed
    44. Chaillon A, Hoenigl M, Mehta SR, Weibel N, Little SJ, Smith D. A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics. Sci Rep. 2016 06 24; 6:28707. PMID: 27337983.
      View in: PubMed
    45. Dan JM, Massanella M, Smith D, Spina CA, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S. Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART. J Acquir Immune Defic Syndr. 2016 06 01; 72(2):133-7. PMID: 26818740.
      View in: PubMed
    46. Marquine MJ, Montoya JL, Umlauf A, Fazeli PL, Gouaux B, Heaton RK, Ellis RJ, Letendre SL, Grant I, Moore DJ. The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clin Infect Dis. 2016 Sep 01; 63(5):694-702. PMID: 27199461; PMCID: PMC4981756 [Available on 09/01/17].
    47. Mehta SR, Murrell B, Anderson CM, Kosakovsky Pond SL, Wertheim JO, Young JA, Freitas L, Richman DD, Mathews WC, Scheffler K, Little SJ, Smith D. Using HIV Sequence and Epidemiologic Data to Assess the Effect of Self-referral Testing for Acute HIV Infection on Incident Diagnoses in San Diego, California. Clin Infect Dis. 2016 Jul 01; 63(1):101-107. PMID: 27174704; PMCID: PMC4901863 [Available on 07/01/17].
    48. Ann HW, Jun S, Shin NY, Han S, Ahn JY, Ahn MY, Jeon YD, Jung IY, Kim MH, Jeong WY, Ku NS, Kim JM, Smith D, Choi JY. Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder. PLoS One. 2016; 11(4):e0153493. PMID: 27104345; PMCID: PMC4841538.
    49. Hoenigl M, Chaillon A, Moore DJ, Morris SR, Smith D, Little SJ. Clear Links Between Starting Methamphetamine and Increasing Sexual Risk Behavior: A Cohort Study Among Men Who Have Sex With Men. J Acquir Immune Defic Syndr. 2016 Apr 15; 71(5):551-7. PMID: 26536321; PMCID: PMC4788567 [Available on 04/15/17].
    50. Chin BS, Chaillon A, Mehta SR, Wertheim JO, Kim G, Shin HS, Smith D. Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol. 2016 10; 88(10):1832-5. PMID: 26990771; PMCID: PMC4969179 [Available on 10/01/17].
    51. Gianella S, Anderson CM, Var SR, Oliveira MF, Lada SM, Vargas MV, Massanella M, Little SJ, Richman DD, Strain MC, Pérez-Santiago J, Smith D. Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection. J Virol. 2016 Apr; 90(8):3944-3952. PMID: 26842469.
      View in: PubMed
    52. Var SR, Day TR, Vitomirov A, Smith D, Soontornniyomkij V, Moore DJ, Achim CL, Mehta SR, Pérez-Santiago J. Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. AIDS. 2016 Mar 27; 30(6):839-48. PMID: 26807965; PMCID: PMC4785088 [Available on 03/27/17].
    53. Turner SS, Gianella S, Yip MJ, van Seggelen WO, Gillies RD, Foster AL, Barbati ZR, Smith D, Fierer DS. Shedding of Hepatitis C Virus in Semen of Human Immunodeficiency Virus-Infected Men. Open Forum Infect Dis. 2016 Mar; 3(2):ofw057. PMID: 27186582; PMCID: PMC4866572.
    54. Kamat R, Doyle KL, Iudicello JE, Morgan EE, Morris S, Smith D, Little SJ, Grant I, Woods SP. Neurobehavioral Disturbances During Acute and Early HIV Infection. Cogn Behav Neurol. 2016 Mar; 29(1):1-10. PMID: 27008244; PMCID: PMC4806542 [Available on 03/01/17].
    55. Geiger R, Smith D, Little SJ, Mehta SR. Validation of the GeneXpert® CT/NG Assay for use with Male Pharyngeal and Rectal Swabs. Austin J HIV AIDS Res. 2016; 3(1). PMID: 27536736.
      View in: PubMed
    56. Hoenigl M, Green N, Camacho M, Gianella S, Mehta SR, Smith D, Little SJ. Signs or Symptoms of Acute HIV Infection in a Cohort Undergoing Community-Based Screening. Emerg Infect Dis. 2016 Mar; 22(3):532-4. PMID: 26890854; PMCID: PMC4766914.
    57. Panichsillapakit T, Smith D, Wertheim JO, Richman DD, Little SJ, Mehta SR. Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):228-36. PMID: 26413846; PMCID: PMC4712087 [Available on 02/01/17].
    58. Panichsillapakit T, Patel D, Santangelo J, Richman DD, Little SJ, Smith D. Colorectal Disorders in Acute Human Immunodeficiency Virus Infection: A Case Series. Open Forum Infect Dis. 2016 Jan; 3(1):ofw014. PMID: 26925432; PMCID: PMC4766383.
    59. Glinka ER, Smith D, Johns ST. Timing Matters - Influenza Vaccination to HIV-Infected Patients. HIV Med. 2016 09; 17(8):601-4. PMID: 26810556.
      View in: PubMed
    60. de Oliveira MF, Murrell B, Pérez-Santiago J, Vargas M, Ellis RJ, Letendre S, Grant I, Smith D, Woods SP, Gianella S. Corrigendum: Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART. Sci Rep. 2016 Jan 19; 6:19387. PMID: 26783252.
      View in: PubMed
    61. Vanpouille C, Introini A, Morris SR, Margolis L, Daar ES, Dube MP, Little SJ, Smith D, Lisco A, Gianella S. Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection. AIDS. 2016 Jan; 30(2):193-201. PMID: 26558730; PMCID: PMC4862605 [Available on 01/01/17].
    62. Geiger R, Smith D, Little SJ, Mehta SR. RETRACTED: Investigation of the GeneXpert® CT/NG assay for use with male pharyngeal and rectal swabs. Int J STD AIDS. 2016 Jan 01; 956462416665059. PMID: 27510643.
      View in: PubMed
    63. Shi Y, Wang J, Wang Y, Wang A, Guo H, Wei F, Mehta SR, Espitia S, Smith D, Liu L, Zhang Y, Chen D. A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines. Cancer Lett. 2016 Feb 28; 371(2):285-91. PMID: 26706415; PMCID: PMC4934374 [Available on 02/28/17].
    64. de Oliveira MF, Murrell B, Murrel B, Pérez-Santiago J, Vargas M, Ellis RJ, Letendre S, Grant I, Smith D, Woods SP, Gianella S. Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART. Sci Rep. 2015 Nov 25; 5:17094. PMID: 26603568; PMCID: PMC4658529.
    65. Tilghman M, Tsai D, Buene TP, Tomas M, Amade S, Gehlbach D, Chang S, Ignacio C, Caballero G, Espitia S, May S, Noormahomed EV, Smith D. Pooled Nucleic Acid Testing to Detect Antiretroviral Treatment Failure in HIV-Infected Patients in Mozambique. J Acquir Immune Defic Syndr. 2015 Nov 01; 70(3):256-61. PMID: 26135327; PMCID: PMC4607635 [Available on 11/01/16].
    66. Gianella S, Anderson CM, Richman DD, Smith D, Little SJ. No evidence of posttreatment control after early initiation of antiretroviral therapy. AIDS. 2015 Oct 23; 29(16):2093-7. PMID: 26544575; PMCID: PMC4638137 [Available on 10/23/16].
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    77. Wang X, Wu Y, Mao L, Xia W, Zhang W, Dai L, Mehta SR, Wertheim JO, Dong X, Zhang T, Wu H, Smith D. Targeting HIV Prevention Based on Molecular Epidemiology Among Deeply Sampled Subnetworks of Men Who Have Sex With Men. Clin Infect Dis. 2015 Nov 01; 61(9):1462-8. PMID: 26129754; PMCID: PMC4599390 [Available on 11/01/16].
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    81. Saravanan S, Gomathi S, Kausalya B, Boobalan J, Murugavel KG, Balakrishnan P, Mothi SN, Solomon SS, Kumarasamy N, Selvamuthu P, Solomon S, Smith D. Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses. AIDS Res Hum Retroviruses. 2015 Jun; 31(6):655-7. PMID: 25839730; PMCID: PMC4458742.
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    83. Hoenigl M, Weibel N, Mehta SR, Anderson CM, Jenks J, Green N, Gianella S, Smith D, Little SJ. Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men. Clin Infect Dis. 2015 Aug 01; 61(3):468-75. PMID: 25904374; PMCID: PMC4542926.
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    88. Heaton RK, Franklin DR, Deutsch R, Letendre SL, Ellis RJ, Casaletto K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Smith D, Grant I. Reply to Haddow et al. Clin Infect Dis. 2015 May 01; 60(9):1442-3. PMID: 25645217; PMCID: PMC4415055.
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    90. Ene L, Duiculescu D, Tardei G, Ruta S, Smith D, Mehta S, Letendre S, Achim CL. Hepatitis B virus compartmentalization in the cerebrospinal fluid of HIV-infected patients. Clin Microbiol Infect. 2015 Apr; 21(4):387.e5-8. PMID: 25658525; PMCID: PMC4424164.
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    92. Carter CC, Wagner GA, Hightower GK, Caballero G, Phung P, Richman DD, Pond SL, Smith D. HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing. Virology. 2015 Jan 01; 474:34-40. PMID: 25463602; PMCID: PMC4259848.
    93. Heaton RK, Franklin DR, Deutsch R, Letendre S, Ellis RJ, Casaletto K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, Abramson I, Gamst AC, Fennema-Notestine C, Smith D, Grant I. Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis. 2015 Feb 01; 60(3):473-80. PMID: 25362201; PMCID: PMC4303775.
    94. Hepler NL, Scheffler K, Weaver S, Murrell B, Richman DD, Burton DR, Poignard P, Smith D, Kosakovsky Pond SL. IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform. PLoS Comput Biol. 2014 Sep; 10(9):e1003842. PMID: 25254639; PMCID: PMC4177671.
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    96. Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, Smith D, Masliah E, Grant I. Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. PLoS One. 2014; 9(7):e102555. PMID: 25054922; PMCID: PMC4108358.
    97. Rotta I, Raboni SM, Ribeiro CE, Riedel M, Winhescki Mda G, Smith D, Ellis RJ, de Almeida SM. Cerebrospinal fluid can be used for HIV genotyping when it fails in blood. Arq Neuropsiquiatr. 2014 Jul; 72(7):506-9. PMID: 25054982; PMCID: PMC4139176.
    98. Wertheim JO, Smith MD, Smith D, Scheffler K, Kosakovsky Pond SL. Evolutionary origins of human herpes simplex viruses 1 and 2. Mol Biol Evol. 2014 Sep; 31(9):2356-64. PMID: 24916030; PMCID: PMC4137711.
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    100. Orlov M, Vaida F, Williamson K, Deng Q, Smith D, Duffy PE, Schooley RT. Antigen-presenting phagocytic cells ingest malaria parasites and increase HIV replication in a tumor necrosis factor a-dependent manner. J Infect Dis. 2014 Nov 15; 210(10):1562-72. PMID: 24903666; PMCID: PMC4215075.
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    109. Noormahomed EV, Mocumbi AO, Preziosi M, Damasceno A, Bickler S, Smith D, Funzamo C, Aronoff-Spencer E, Badaró R, Mabila F, Bila D, Nguenha A, Do Rosário V, Benson CA, Schooley RT, Patel S, Ferrão LJ, Carrilho C. Strengthening research capacity through the medical education partnership initiative: the Mozambique experience. Hum Resour Health. 2013 Dec 05; 11:62. PMID: 24304706; PMCID: PMC3895849.
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    111. de Almeida SM, Ribeiro CE, de Pereira AP, Badiee J, Cherner M, Smith D, Maich I, Raboni SM, Rotta I, Barbosa FJ, Heaton RK, Umlauf A, Ellis RJ. Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil. J Neurovirol. 2013 Dec; 19(6):550-6. PMID: 24277437.
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    129. Desplats P, Dumaop W, Smith D, Adame A, Everall I, Letendre S, Ellis R, Cherner M, Grant I, Masliah E. Molecular and pathologic insights from latent HIV-1 infection in the human brain. Neurology. 2013 Apr 09; 80(15):1415-23. PMID: 23486877; PMCID: PMC3662272.
    130. Kim H, Ku NS, Kim SB, Jeong SJ, Han SH, Kim JM, Smith D, Choi JY. Simulation of pooled nucleic acid testing to identify antiretroviral treatment failure during HIV infection in Seoul, South Korea. J Acquir Immune Defic Syndr. 2013 Mar 01; 62(3):e104-5. PMID: 23924640; PMCID: PMC3873092.
    131. Morgan EE, Woods SP, Letendre SL, Franklin DR, Bloss C, Goate A, Heaton RK, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Ellis RJ, Abramson I, Gamst A, Fennema-Notestine C, Smith D, Grant I, Vaida F, Clifford DB. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. J Neurovirol. 2013 Apr; 19(2):150-6. PMID: 23408335.
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    133. Le T, Wright EJ, Smith D, He W, Catano G, Okulicz JF, Young JA, Clark RA, Richman DD, Little SJ, Ahuja SK. Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med. 2013 Jan 17; 368(3):218-30. PMID: 23323898; PMCID: PMC3657555.
    134. Wertheim JO, Scheffler K, Choi JY, Smith D, Kosakovsky Pond SL. Phylogenetic relatedness of HIV-1 donor and recipient populations. J Infect Dis. 2013 Apr; 207(7):1181-2. PMID: 23315327; PMCID: PMC3583277.
    135. Gianella S, Morris SR, Anderson C, Spina CA, Vargas MV, Young JA, Richman DD, Little SJ, Smith D. Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS. 2013 Jan 02; 27(1):39-47. PMID: 22739399; PMCID: PMC3769229.
    136. Gianella S, Anderson CM, Vargas MV, Richman DD, Little SJ, Morris SR, Smith D. Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA. J Infect Dis. 2013 Mar 15; 207(6):898-902. PMID: 23275608; PMCID: PMC3571441.
    137. Fierer DS, Dieterich DT, Fiel MI, Branch AD, Marks KM, Fusco DN, Hsu R, Smith D, Fierer J. Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection. Clin Infect Dis. 2013 Apr; 56(7):1038-43. PMID: 23264364; PMCID: PMC3588118.
    138. Weber E, Morgan EE, Iudicello JE, Blackstone K, Grant I, Ellis RJ, Letendre SL, Little S, Morris S, Smith D, Moore DJ, Woods SP. Substance use is a risk factor for neurocognitive deficits and neuropsychiatric distress in acute and early HIV infection. J Neurovirol. 2013 Feb; 19(1):65-74. PMID: 23250704; PMCID: PMC3568179.
    139. Saravanan S, Madhavan V, Balakrishnan P, Smith D, Solomon SS, Sivamalar S, Poongulali S, Kumarasamy N, Schooley RT, Solomon S, Kantor R. Darunavir is a good third-line antiretroviral agent for HIV type 1-infected patients failing second-line protease inhibitor-based regimens in South India. AIDS Res Hum Retroviruses. 2013 Mar; 29(3):630-2. PMID: 23045961; PMCID: PMC3581023.
    140. Gianella S, Morris SR, Vargas MV, Young JA, Callahan B, Richman DD, Little SJ, Smith D. Role of seminal shedding of herpesviruses in HIV Type 1 Transmission. J Infect Dis. 2013 Jan 15; 207(2):257-61. PMID: 23148284; PMCID: PMC3532824.
    141. Orlov M, Vaida F, Finney OC, Smith D, Talley AK, Wang R, Kappe SH, Deng Q, Schooley RT, Duffy PE. P. falciparum enhances HIV replication in an experimental malaria challenge system. PLoS One. 2012; 7(6):e39000. PMID: 22745697; PMCID: PMC3383717.
    142. Smith D. Active duty military personnel presenting for care at a Gay Men's Health Clinic. J Homosex. 2008; 54(3):277-9. PMID: 18825864.
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    143. Smith D, Wong JK, Hightower GK, Ignacio CC, Koelsch KK, Petropoulos CJ, Richman DD, Little SJ. HIV drug resistance acquired through superinfection. AIDS. 2005 Aug 12; 19(12):1251-6. PMID: 16052079.
      View in: PubMed
    144. Smith D, Metzgar D, Wills C, Fierer J. Fatal Saccharomyces cerevisiae aortic graft infection. J Clin Microbiol. 2002 Jul; 40(7):2691-2. PMID: 12089311; PMCID: PMC120603.
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