Hal Hoffman

Title(s)Professor, Medicine
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    University of Texas Medical Branch , Galveston, TSMDMedicine
    Wesleyan University, Middletown, CTBABiology

    Collapse Overview 
    Collapse Overview
    Research Interests
    Regulation of cytokines and inflammation by cryopyrin. Research focus on the genetics of inflammatory disorders, positional cloning of target genes and the function of such genes in the expression of inflammation.

    Collapse Research 
    Collapse Research Activities and Funding
    Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
    NIH/NHLBI R01HL140898Jan 1, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Sterile inflammation and pyroptotic cell death in liver fibrosis
    NIH/NIDDK R01DK113592Mar 1, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    Transcriptional Control of Lung Macrophage Development
    NIH/NHLBI R01HL126703May 15, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Targeting inflammasome mediated disorders with green tea
    NIH/NIAID R21AI090487Jun 15, 2010 - May 31, 2012
    Role: Principal Investigator
    Novel regulatory role of cryopyrin in inflammation
    NIH/NIAID R21AI061108Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator
    The Role of Cryopyrin in Autoinflammatory Diseases
    NIH/NIAID R01AI052430Aug 1, 2002 - Jul 31, 2013
    Role: Principal Investigator
    NIH/NIAID K08AI001508Jan 1, 1998 - Dec 31, 2002
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hoffman HM, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14. PMID: 27373321.
      View in: PubMed
    2. Hoffman HM, Throne ML, Amar NJ, Cartwright RC, Kivitz AJ, Soo Y, Weinstein SP. Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study. Clin Ther. 2012 Oct; 34(10):2091-103. PMID: 23031624.
      View in: PubMed
    3. Hoffman HM, Brydges SD. Genetic and molecular basis of inflammasome-mediated disease. J Biol Chem. 2011 Apr 01; 286(13):10889-96. PMID: 21296874; PMCID: PMC3064144.
    4. Hoffman HM, Wanderer AA. Inflammasome and IL-1beta-mediated disorders. Curr Allergy Asthma Rep. 2010 Jul; 10(4):229-35. PMID: 20425006; PMCID: PMC2892083.
    5. Hoffman HM. Therapy of autoinflammatory syndromes. J Allergy Clin Immunol. 2009 Dec; 124(6):1129-38; quiz 1139-40. PMID: 20004774; PMCID: PMC4508191.
    6. Hoffman HM, Simon A. Recurrent febrile syndromes: what a rheumatologist needs to know. Nat Rev Rheumatol. 2009 May; 5(5):249-56. PMID: 19412191.
      View in: PubMed
    7. Hoffman HM. Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS). Expert Opin Biol Ther. 2009 Apr; 9(4):519-31. PMID: 19344287.
      View in: PubMed
    8. Hoffman HM, Wolfe F, Belomestnov P, Mellis SJ. Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity. Curr Med Res Opin. 2008 Sep; 24(9):2531-43. PMID: 18667113.
      View in: PubMed
    9. Hoffman HM. Hereditary immunologic disorders caused by pyrin and cryopyrin. Curr Allergy Asthma Rep. 2007 Sep; 7(5):323-30. PMID: 17697637.
      View in: PubMed
    10. Hoffman HM, Firestein GS. Anakinra for the treatment of neonatal-onset multisystem inflammatory disease. Nat Clin Pract Rheumatol. 2006 Dec; 2(12):646-7. PMID: 17133246.
      View in: PubMed
    11. Hoffman HM, Rosengren S, Boyle DL, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004 Nov 13-19; 364(9447):1779-85. PMID: 15541451; PMCID: PMC4321997.
    12. Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD. Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet. 2003 Feb; 112(2):209-16. PMID: 12522564.
      View in: PubMed
    13. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 2001 Nov; 29(3):301-5. PMID: 11687797; PMCID: PMC4322000.
    14. Hoffman HM, Bastian JF, Bird LM. Humoral immunodeficiency with facial dysmorphology and limb anomalies: a new syndrome. Clin Dysmorphol. 2001 Jan; 10(1):1-8. PMID: 11152140.
      View in: PubMed
    15. Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD. Identification of a locus on chromosome 1q44 for familial cold urticaria. Am J Hum Genet. 2000 May; 66(5):1693-8. PMID: 10741953; PMCID: PMC1378006.