Our site may be slower due to heavy traffic from automated "bots" and AI crawlers. We're working to fix this.

Hal Hoffman

Photo of Hal Hoffman
Title(s)Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    University of Texas Medical Branch , Galveston, TSMDMedicine
    Wesleyan University, Middletown, CTBABiology

    Collapse Overview 
    Collapse overview
    Research Interests
    Regulation of cytokines and inflammation by cryopyrin. Research focus on the genetics of inflammatory disorders, positional cloning of target genes and the function of such genes in the expression of inflammation.

    Collapse Research 
    Collapse research activities and funding
    Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
    NIH R01HL140898Jan 1, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Sterile inflammation and pyroptotic cell death in liver fibrosis
    NIH R01DK113592Mar 1, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    Transcriptional Control of Lung Macrophage Development
    NIH R01HL126703May 15, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Targeting inflammasome mediated disorders with green tea
    NIH/NIAID R21AI090487Jun 15, 2010 - May 31, 2012
    Role: Principal Investigator
    Novel regulatory role of cryopyrin in inflammation
    NIH/NIAID R21AI061108Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator
    The Role of Cryopyrin in Autoinflammatory Diseases
    NIH/NIAID R01AI052430Aug 1, 2002 - Jul 31, 2013
    Role: Principal Investigator
    GENETIC AND MOLECULAR BASIS OF FAMILIAL COLD URTICARIA
    NIH/NIAID K08AI001508Jan 1, 1998 - Dec 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Development of a Mouse Model of Coccidioidomycosis Using an Inhalation Exposure System. J Fungi (Basel). 2025 Aug 19; 11(8). Erlich JR, Rodriguez P, Yau KPS, Tate M, Carlin AF, Fierer J, Kirkland TN, Hoffman HM, Beyhan S, Croker BA. PMID: 40863551; PMCID: PMC12387420.
      View in: PubMed   Mentions:
    2. Differential Diagnosis of Chronic Spontaneous Urticaria. J Allergy Clin Immunol Pract. 2025 Sep; 13(9):2242-2250. Gialama D, Bonnekoh H, Rothermel ND, Oldenburg R, Khan DA, Hoffman HM, Lang D, Kolkhir P. PMID: 40562278.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation. Nat Immunol. 2025 Jul; 26(7):1168-1181. Xian H, Watari K, Ohira M, Brito JS, He P, Onyuru J, Zuniga EI, Hoffman HM, Karin M. PMID: 40528028.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950. bioRxiv. 2025 Jun 08. Lackner A, Leonidas L, Macapagal A, Lee H, Xu H, Qiu Y, Campos M, Cabral JE, Onyuru J, Kulkarni S, Albrecht LV, Hoffman HM, McNulty R. PMID: 40661406; PMCID: PMC12258936.
      View in: PubMed   Mentions:
    5. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. bioRxiv. 2025 May 31. Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. PMID: 40501605; PMCID: PMC12154967.
      View in: PubMed   Mentions:
    6. Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation. bioRxiv. 2025 May 01. Klein R, Onyuru J, Centa JL, Viera EM, Duelli FJ, Putnam CD, Hoffman HM, Hastings ML. PMID: 39282364; PMCID: PMC11398476.
      View in: PubMed   Mentions:
    7. The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice. JCI Insight. 2024 Nov 08; 9(21). Pessentheiner AR, Spann NJ, Autran CA, Oh TG, Grunddal KV, Coker JK, Painter CD, Ramms B, Chiang AW, Wang CY, Hsiao J, Wang Y, Quach A, Booshehri LM, Hammond A, Tognaccini C, Latasiewicz J, Willemsen L, Zengler K, de Winther MP, Hoffman HM, Philpott M, Cribbs AP, Oppermann U, Lewis NE, Witztum JL, Yu R, Atkins AR, Downes M, Evans RM, Glass CK, Bode L, Gordts PL. PMID: 39325548; PMCID: PMC11601559.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Publisher Correction: IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2024 Jul; 20(7):452. Broderick L, Hoffman HM. PMID: 38783116; PMCID: PMC11836985.
      View in: PubMed   Mentions:    Fields:    
    9. Cell Death in Liver Disease and Liver Surgery. Biomedicines. 2024 Mar 01; 12(3). Stoess C, Choi YK, Onyuru J, Friess H, Hoffman HM, Hartmann D, Feldstein AE. PMID: 38540172; PMCID: PMC10968531.
      View in: PubMed   Mentions: 7  
    10. NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2024 Jan; 25(1):455. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 38216786; PMCID: PMC10897131.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity. Immunol Rev. 2024 03; 322(1):259-282. Putnam CD, Broderick L, Hoffman HM. PMID: 38146057; PMCID: PMC10950545.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    12. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. Sci Adv. 2023 12 22; 9(51):eadj1397. Zhu YP, Speir M, Tan Z, Lee JC, Nowell CJ, Chen AA, Amatullah H, Salinger AJ, Huang CJ, Wu G, Peng W, Askari K, Griffis E, Ghassemian M, Santini J, Gerlic M, Kiosses WB, Catz SD, Hoffman HM, Greco KF, Weller E, Thompson PR, Wong LP, Sadreyev R, Jeffrey KL, Croker BA. PMID: 38117877; PMCID: PMC10732518.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    13. BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation. Cell Mol Gastroenterol Hepatol. 2024; 17(3):481-497. Kui L, Kim AD, Onyuru J, Hoffman HM, Feldstein AE. PMID: 38092312; PMCID: PMC10837621.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    14. Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep. 2023 Nov 16; 13(1):20081. Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. PMID: 37973811; PMCID: PMC10654444.
      View in: PubMed   Mentions:    Fields:    
    15. JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep. 2023 08 19; 13(1):13524. Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. PMID: 37598239; PMCID: PMC10439952.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    16. Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children. Int J Mol Sci. 2023 Aug 01; 24(15). Kim J, Shimizu C, He M, Wang H, Hoffman HM, Tremoulet AH, Shyy JY, Burns JC. PMID: 37569694; PMCID: PMC10418493.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice. J Immunol. 2023 07 15; 211(2):287-294. Kaufmann B, de Los Reyes Jiménez M, Booshehri LM, Onyuru J, Leszczynska A, Uri A, Michel S, Klar R, Jaschinski F, Feldstein AE, Broderick L, Hoffman HM. PMID: 37256266.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis. J Pharmacol Exp Ther. 2023 08; 386(2):242-258. Povero D, Lazic M, McBride C, Ambrus-Aikelin G, Stansfield R, Johnson CD, Santini AM, Pranadinata RF, McGeough MD, Stafford JA, Hoffman HM, Feldstein AE, Veal JM, Bain G. PMID: 37308266.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. Author Correction: Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023 Jun 12; 6(1):632. Cabral A, Cabral JE, Wang A, Zhang Y, Liang H, Nikbakht D, Corona L, Hoffman HM, McNulty R. PMID: 37308785; PMCID: PMC10260916.
      View in: PubMed   Mentions: 1  
    20. Cold Urticaria Syndromes: Diagnosis and Management. J Allergy Clin Immunol Pract. 2023 08; 11(8):2275-2285. Diaz VL, Gribbons KB, Yazdi-Nejad K, Kuemmerle-Deschner J, Wanderer AA, Broderick L, Hoffman HM. PMID: 37290539.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders. Sci Transl Med. 2023 05 31; 15(698):eade3856. Colantuoni M, Jofra Hernandez R, Pettinato E, Basso-Ricci L, Magnani L, Andolfi G, Rigamonti C, Finardi A, Romeo V, Soldi M, Sergi Sergi L, Rocchi M, Scala S, Hoffman HM, Gregori S, Kajaste-Rudnitski A, Sanvito F, Muzio L, Naldini L, Aiuti A, Mortellaro A. PMID: 37256935.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023 05 30; 6(1):578. Cabral A, Cabral JE, Wang A, Zhang Y, Liang H, Nikbakht D, Corona L, Hoffman HM, McNulty R. PMID: 37253813; PMCID: PMC10229695.
      View in: PubMed   Mentions: 15  Translation:HumansCells
    23. Mimickers of Classical Urticaria: Cryopyrin-Associated Autoinflammatory Syndrome Presenting as Isolated Urticaria in an Infant. J Allergy Clin Immunol Pract. 2023 03; 11(3):941-942. Solomon BD, Skaljic M, Liu LY, Yan D, Sheahon KM, Broderick L, Hoffman HM, Beres SJ, Brown RA, Teng JMC, Gernez Y. PMID: 36720659.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Long-term exposure to house dust mites accelerates lung cancer development in mice. J Exp Clin Cancer Res. 2023 Jan 21; 42(1):26. Wang D, Li W, Albasha N, Griffin L, Chang H, Amaya L, Ganguly S, Zeng L, Keum B, González-Navajas JM, Levin M, AkhavanAghdam Z, Snyder H, Schwartz D, Tao A, Boosherhri LM, Hoffman HM, Rose M, Estrada MV, Varki N, Herdman S, Corr M, Webster NJG, Raz E, Bertin S. PMID: 36670473; PMCID: PMC9863279.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    25. Rapid genome sequencing identifies novel variants in complement factor I. Cold Spring Harb Mol Case Stud. 2022 12; 8(7). Rodriguez KM, Vaught J, Dilley M, Ellsworth K, Heinen A, Abud EM, Zhang Y, Smith RJH, Sheets R, Geng B, Hoffman HM, Worthen HM, Dimmock D, Coufal NG. PMID: 36577522; PMCID: PMC9808552.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Hepatology. 2023 06 01; 77(6):1968-1982. Knorr J, Kaufmann B, Inzaugarat ME, Holtmann TM, Geisler L, Hundertmark J, Kohlhepp MS, Boosheri LM, Chilin-Fuentes DR, Birmingham A, Fisch KM, Schilling JD, Loosen SH, Trautwein C, Roderburg C, Demir M, Tacke F, Hoffman HM, Feldstein AE, Wree A. PMID: 36059147; PMCID: PMC9984672.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    27. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome. J Allergy Clin Immunol. 2023 04; 151(4):1081-1095. Leiding JW, Vogel TP, Santarlas VGJ, Mhaskar R, Smith MR, Carisey A, Vargas-Hernández A, Silva-Carmona M, Heeg M, Rensing-Ehl A, Neven B, Hadjadj J, Hambleton S, Ronan Leahy T, Meesilpavikai K, Cunningham-Rundles C, Dutmer CM, Sharapova SO, Taskinen M, Chua I, Hague R, Klemann C, Kostyuchenko L, Morio T, Thatayatikom A, Ozen A, Scherbina A, Bauer CS, Flanagan SE, Gambineri E, Giovannini-Chami L, Heimall J, Sullivan KE, Allenspach E, Romberg N, Deane SG, Prince BT, Rose MJ, Bohnsack J, Mousallem T, Jesudas R, Santos Vilela MMD, O'Sullivan M, Pachlopnik Schmid J, Pruhová Š, Klocperk A, Rees M, Su H, Bahna S, Baris S, Bartnikas LM, Chang Berger A, Briggs TA, Brothers S, Bundy V, Chan AY, Chandrakasan S, Christiansen M, Cole T, Cook MC, Desai MM, Fischer U, Fulcher DA, Gallo S, Gauthier A, Gennery AR, Gonçalo Marques J, Gottrand F, Grimbacher B, Grunebaum E, Haapaniemi E, Hämäläinen S, Heiskanen K, Heiskanen-Kosma T, Hoffman HM, Gonzalez-Granado LI, Guerrerio AL, Kainulainen L, Kumar A, Lawrence MG, Levin C, Martelius T, Neth O, Olbrich P, Palma A, Patel NC, Pozos T, Preece K, Lugo Reyes SO, Russell MA, Schejter Y, Seroogy C, Sinclair J, Skevofilax E, Suan D, Suez D, Szabolcs P, Velasco H, Warnatz K, Walkovich K, Worth A, STAT3 GOF Working Group members, Seppänen MRJ, Torgerson TR, Sogkas G, Ehl S, Tangye SG, Cooper MA, Milner JD, Forbes Satter LR. PMID: 36228738; PMCID: PMC10081938.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    28. NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2022 11 07; 23(11):e54446. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 36194627; PMCID: PMC9638850.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease. J Am Heart Assoc. 2022 07 19; 11(14):e025408. Shimizu C, Kim J, He M, Tremoulet AH, Hoffman HM, Shyy JY, Burns JC. PMID: 35861833; PMCID: PMC9707837.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
      View in: PubMed   Mentions: 252     Fields:    Translation:AnimalsCells
    31. Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2022; 14(4):751-767. Kaufmann B, Kui L, Reca A, Leszczynska A, Kim AD, Booshehri LM, Wree A, Friess H, Hartmann D, Broderick L, Hoffman HM, Feldstein AE. PMID: 35787975; PMCID: PMC9424559.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    32. IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2022 08; 18(8):448-463. Broderick L, Hoffman HM. PMID: 35729334; PMCID: PMC9210802.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    33. The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin-1 Receptor Antagonist. Arthritis Rheumatol. 2022 07; 74(7):1102-1121. Romano M, Arici ZS, Piskin D, Alehashemi S, Aletaha D, Barron K, Benseler S, Berard RA, Broderick L, Dedeoglu F, Diebold M, Durrant K, Ferguson P, Foell D, Hausmann JS, Jones OY, Kastner D, Lachmann HJ, Laxer RM, Rivera D, Ruperto N, Simon A, Twilt M, Frenkel J, Hoffman HM, de Jesus AA, Kuemmerle-Deschner JB, Ozen S, Gattorno M, Goldbach-Mansky R, Demirkaya E. PMID: 35621220; PMCID: PMC9531906.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    34. NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH. Hepatology. 2022 09; 76(3):727-741. Calcagno DM, Chu A, Gaul S, Taghdiri N, Toomu A, Leszczynska A, Kaufmann B, Papouchado B, Wree A, Geisler L, Hoffman HM, Feldstein AE, King KR. PMID: 34997987; PMCID: PMC10176600.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    35. Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C. J Clin Invest. 2021 10 15; 131(20). Zhu YP, Shamie I, Lee JC, Nowell CJ, Peng W, Angulo S, Le LN, Liu Y, Miao H, Xiong H, Pena CJ, Moreno E, Griffis E, Labou SG, Franco A, Broderick L, Hoffman HM, Shimizu C, Lewis NE, Kanegaye JT, Tremoulet AH, Burns JC, Croker BA, Pediatric Emergency Medicine Kawasaki Disease Research Group Consortium. PMID: 34464357; PMCID: PMC8516453.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    36. Activin A Signaling Provides an Interorgan Link Between Kidney and Muscle in CKD-Associated Muscle Wasting. Am J Kidney Dis. 2022 02; 79(2):302-304. Perens EA, Hoffman HM, Mak RH. PMID: 34653537.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021 10 04; 218(10). Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, Jönsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL. PMID: 34477811; PMCID: PMC8421266.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    38. The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia. Sci Rep. 2021 07 23; 11(1):15141. Cheung WW, Zheng R, Hao S, Wang Z, Gonzalez A, Zhou P, Hoffman HM, Mak RH. PMID: 34302016; PMCID: PMC8302616.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome. Arterioscler Thromb Vasc Biol. 2021 09; 41(9):2509-2511. Wang WT, He M, Shimizu C, Croker BA, Hoffman HM, Tremoulet AH, Burns JC, Shyy JY. PMID: 34261329; PMCID: PMC8387357.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    40. Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis. J Cachexia Sarcopenia Muscle. 2021 10; 12(5):1296-1311. Cheung WW, Hao S, Zheng R, Wang Z, Gonzalez A, Zhou P, Hoffman HM, Mak RH. PMID: 34196133; PMCID: PMC8517356.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    41. Long-term safety and effectiveness of canakinumab therapy in patients with cryopyrin-associated periodic syndrome: results from the β-Confident Registry. RMD Open. 2021 05; 7(2). Walker UA, Tilson HH, Hawkins PN, Poll TV, Noviello S, Levy J, Vritzali E, Hoffman HM, Kuemmerle-Deschner JB, CACZ885D2401 Study Investigators. PMID: 34001647; PMCID: PMC8130749.
      View in: PubMed   Mentions: 12  Translation:Humans
    42. Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy. J Infect Dis. 2021 04 08; 223(7):1260-1264. Wilde S, Olivares KL, Nizet V, Hoffman HM, Radhakrishna S, LaRock CN. PMID: 32808035; PMCID: PMC8030709.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Author Correction: A guiding map for inflammation. Nat Immunol. 2021 Feb; 22(2):254. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. PMID: 33288963.
      View in: PubMed   Mentions: 5     Fields:    
    44. Inhibition of the NLRP3 inflammasome prevents ovarian aging. Sci Adv. 2021 01; 7(1). Navarro-Pando JM, Alcocer-Gómez E, Castejón-Vega B, Navarro-Villarán E, Condés-Hervás M, Mundi-Roldan M, Muntané J, Pérez-Pulido AJ, Bullon P, Wang C, Hoffman HM, Sanz A, Mbalaviele G, Ryffel B, Cordero MD. PMID: 33523841; PMCID: PMC7775749.
      View in: PubMed   Mentions: 82     Fields:    
    45. Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach. J Allergy Clin Immunol. 2020 11; 146(5):925-937. Nigrovic PA, Lee PY, Hoffman HM. PMID: 33160483; PMCID: PMC7727443.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    46. Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist. J Allergy Clin Immunol. 2020 11; 146(5):960-966.e2. Broderick L, Hoffman HM. PMID: 33002514; PMCID: PMC8559310.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    47. Vitamin D ameliorates adipose browning in chronic kidney disease cachexia. Sci Rep. 2020 08 25; 10(1):14175. Cheung WW, Ding W, Hoffman HM, Wang Z, Hao S, Zheng R, Gonzalez A, Zhan JY, Zhou P, Li S, Esparza MC, Lieber RL, Mak RH. PMID: 32843714; PMCID: PMC7447759.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    48. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2021 01; 74(1):156-167. Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE. PMID: 32763266; PMCID: PMC7749849.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    49. ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. JCI Insight. 2020 01 30; 5(2). Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE. PMID: 31996485; PMCID: PMC7098717.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    50. Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia. J Cachexia Sarcopenia Muscle. 2020 02; 11(1):120-134. Cheung WW, Hao S, Wang Z, Ding W, Zheng R, Gonzalez A, Zhan JY, Zhou P, Li S, Esparza MC, Hoffman HM, Lieber RL, Mak RH. PMID: 31721480; PMCID: PMC7015252.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    51. Autoinflammatory disease: New mouse models and therapies. J Allergy Clin Immunol. 2020 01; 145(1):116-118. Hoffman HM. PMID: 31676433.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    52. Mutations in topoisomerase IIβ result in a B cell immunodeficiency. Nat Commun. 2019 08 13; 10(1):3644. Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. PMID: 31409799; PMCID: PMC6692411.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    53. Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 07 19; 10(1):3238. Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. PMID: 31324763; PMCID: PMC6642158.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    54. Partial Jacobsen syndrome phenotype in a patient with a de novo frameshift mutation in the ETS1 transcription factor. Cold Spring Harb Mol Case Stud. 2019 06; 5(3). Tootleman E, Malamut B, Akshoomoff N, Mattson SN, Hoffman HM, Jones MC, Printz B, Shiryaev SA, Grossfeld P. PMID: 31160359; PMCID: PMC6549550.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    55. Differential Immune Activation in Fetal Macrophage Populations. Sci Rep. 2019 05 22; 9(1):7677. Lakhdari O, Yamamura A, Hernandez GE, Anderson KK, Lund SJ, Oppong-Nonterah GO, Hoffman HM, Prince LS. PMID: 31118442; PMCID: PMC6531440.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    56. CAPS and NLRP3. J Clin Immunol. 2019 04; 39(3):277-286. Booshehri LM, Hoffman HM. PMID: 31077002; PMCID: PMC8575304.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimals
    57. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734; PMCID: PMC6675591.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    58. NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. Hepatology. 2019 02; 69(2):845-859. Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE. PMID: 30180270; PMCID: PMC6351190.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    59. Neutrophils: New insights and open questions. Sci Immunol. 2018 12 07; 3(30). Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, Catz SD. PMID: 30530726.
      View in: PubMed   Mentions: 276     Fields:    Translation:HumansAnimalsCells
    60. TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation. J Innate Immun. 2019; 11(1):99-108. Oppong-Nonterah GO, Lakhdari O, Yamamura A, Hoffman HM, Prince LS. PMID: 30408777; PMCID: PMC6296861.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    61. In silico validation of the Autoinflammatory Disease Damage Index. Ann Rheum Dis. 2018 11; 77(11):1599-1605. Ter Haar NM, van Delft ALJ, Annink KV, van Stel H, Al-Mayouf SM, Amaryan G, Anton J, Barron KS, Benseler S, Brogan PA, Cantarini L, Cattalini M, Cochino AV, de Benedetti F, Dedeoglu F, de Jesus AA, Demirkaya E, Dolezalova P, Durrant KL, Fabio G, Gallizzi R, Goldbach-Mansky R, Hachulla E, Hentgen V, Herlin T, Hofer M, Hoffman HM, Insalaco A, Jansson AF, Kallinich T, Kone-Paut I, Kozlova A, Kuemmerle-Deschner JB, Lachmann HJ, Laxer RM, Martini A, Nielsen S, Nikishina I, Ombrello AK, Özen S, Papadopoulou-Alataki E, Quartier P, Rigante D, Russo R, Simon A, Trachana M, Uziel Y, Ravelli A, Schulert G, Gattorno M, Frenkel J. PMID: 30077992; PMCID: PMC8411437.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    62. CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis. JCI Insight. 2018 06 21; 3(12). Willeford A, Suetomi T, Nickle A, Hoffman HM, Miyamoto S, Heller Brown J. PMID: 29925681; PMCID: PMC6124412.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    63. JAK inhibitors in autoinflammation. J Clin Invest. 2018 07 02; 128(7):2760-2762. Hoffman HM, Broderick L. PMID: 29889100; PMCID: PMC6025991.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    64. Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes. N Engl J Med. 2018 05 17; 378(20):1908-1919. De Benedetti F, Gattorno M, Anton J, Ben-Chetrit E, Frenkel J, Hoffman HM, Koné-Paut I, Lachmann HJ, Ozen S, Simon A, Zeft A, Calvo Penades I, Moutschen M, Quartier P, Kasapcopur O, Shcherbina A, Hofer M, Hashkes PJ, Van der Hilst J, Hara R, Bujan-Rivas S, Constantin T, Gul A, Livneh A, Brogan P, Cattalini M, Obici L, Lheritier K, Speziale A, Junge G. PMID: 29768139.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansCTClinical Trials
    65. Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals. J Exp Med. 2018 05 07; 215(5):1315-1325. Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G. PMID: 29549113; PMCID: PMC5940269.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    66. NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice. Hepatology. 2018 02; 67(2):736-749. Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE. PMID: 28902427; PMCID: PMC5849484.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    67. Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis. Front Cell Infect Microbiol. 2017; 7:507. Johnson JL, Ramadass M, Haimovich A, McGeough MD, Zhang J, Hoffman HM, Catz SD. PMID: 29322034; PMCID: PMC5732154.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    68. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929; PMCID: PMC5707143.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    69. Clinical and Molecular Phenotypes of Low-Penetrance Variants of NLRP3: Diagnostic and Therapeutic Challenges. Arthritis Rheumatol. 2017 11; 69(11):2233-2240. Kuemmerle-Deschner JB, Verma D, Endres T, Broderick L, de Jesus AA, Hofer F, Blank N, Krause K, Rietschel C, Horneff G, Aksentijevich I, Lohse P, Goldbach-Mansky R, Hoffman HM, Benseler SM. PMID: 28692792.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    70. Safety of vaccinations in patients with cryopyrin-associated periodic syndromes: a prospective registry based study. Rheumatology (Oxford). 2017 09 01; 56(9):1484-1491. Jaeger VK, Hoffman HM, van der Poll T, Tilson H, Seibert J, Speziale A, Junge G, Franke K, Vritzali E, Hawkins PN, Kuemmerle-Deschner J, Walker UA. PMID: 28482054.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansPHPublic Health
    71. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7766-E7775. Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. PMID: 28847925; PMCID: PMC5604003.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    72. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Oct; 2(10):1425-1434. Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. PMID: 28784982; PMCID: PMC5750061.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    73. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. PMID: 28722720; PMCID: PMC5939996.
      View in: PubMed   Mentions: 353     Fields:    Translation:Humans
    74. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30; 127(7):2829-2841. Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. PMID: 28530644; PMCID: PMC5490775.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    75. The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L861-L872. Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince LS. PMID: 28336813; PMCID: PMC5495951.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    76. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. J Immunol. 2017 04 15; 198(8):3017-3022. Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH. PMID: 28275141; PMCID: PMC5399887.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    77. Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 02; 69(2):253-256. Hoffman HM, Broderick L. PMID: 27748054; PMCID: PMC5538189.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    78. Development of the autoinflammatory disease damage index (ADDI). Ann Rheum Dis. 2017 May; 76(5):821-830. Ter Haar NM, Annink KV, Al-Mayouf SM, Amaryan G, Anton J, Barron KS, Benseler SM, Brogan PA, Cantarini L, Cattalini M, Cochino AV, De Benedetti F, Dedeoglu F, De Jesus AA, Della Casa Alberighi O, Demirkaya E, Dolezalova P, Durrant KL, Fabio G, Gallizzi R, Goldbach-Mansky R, Hachulla E, Hentgen V, Herlin T, Hofer M, Hoffman HM, Insalaco A, Jansson AF, Kallinich T, Koné-Paut I, Kozlova A, Kuemmerle-Deschner JB, Lachmann HJ, Laxer RM, Martini A, Nielsen S, Nikishina I, Ombrello AK, Ozen S, Papadopoulou-Alataki E, Quartier P, Rigante D, Russo R, Simon A, Trachana M, Uziel Y, Ravelli A, Gattorno M, Frenkel J. PMID: 27811147.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    79. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13132-13137. Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH. PMID: 27799535; PMCID: PMC5135378.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    80. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017 Jun; 76(6):942-947. Kuemmerle-Deschner JB, Ozen S, Tyrrell PN, Kone-Paut I, Goldbach-Mansky R, Lachmann H, Blank N, Hoffman HM, Weissbarth-Riedel E, Hugle B, Kallinich T, Gattorno M, Gul A, Ter Haar N, Oswald M, Dedeoglu F, Cantarini L, Benseler SM. PMID: 27707729.
      View in: PubMed   Mentions: 84     Fields:    Translation:Humans
    81. IL-1β is an innate immune sensor of microbial proteolysis. Sci Immunol. 2016 Aug; 1(2). LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. PMID: 28331908; PMCID: PMC5358671.
      View in: PubMed   Mentions: 75     Fields:    
    82. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14. Hoffman HM, Broderick L. PMID: 27373321.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    83. IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development. J Immunol. 2016 Apr 15; 196(8):3411-20. Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS. PMID: 26951798; PMCID: PMC5315059.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    84. Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2016 05; 36(5):886-97. Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M. PMID: 26941015; PMCID: PMC4850105.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    85. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428; PMCID: PMC4769378.
      View in: PubMed   Mentions: 611     Fields:    Translation:AnimalsCells
    86. Brief Report: Severe Inflammation Following Vaccination Against Streptococcus pneumoniae in Patients With Cryopyrin-Associated Periodic Syndromes. Arthritis Rheumatol. 2016 Feb; 68(2):516-20. Walker UA, Hoffman HM, Williams R, Kuemmerle-Deschner J, Hawkins PN. PMID: 26808830.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    87. The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis. PLoS One. 2015; 10(12):e0144651. Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS. PMID: 26656423; PMCID: PMC4678166.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    88. IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β. Arterioscler Thromb Vasc Biol. 2015 Dec; 35(12):2605-16. Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M. PMID: 26515418; PMCID: PMC4662607.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    89. The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. Immunity. 2015 Aug 18; 43(2):264-76. de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C. PMID: 26275995; PMCID: PMC4666005.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    90. Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism. J Immunol. 2015 Jul 15; 195(2):488-97. Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK. PMID: 26056255.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    91. Transplantation: Outcomes of prenatal immunosuppression. Nat Rev Nephrol. 2015 Jul; 11(7):390-1. Mak RH, Hoffman HM. PMID: 25986424.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    92. A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response. mBio. 2015 Mar 10; 6(2):e00133. Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V. PMID: 25759502; PMCID: PMC4453525.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    93. Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart. Cardiovasc Res. 2015 Feb 01; 105(2):203-12. Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A. PMID: 25524927; PMCID: PMC4357795.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    94. NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79. Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. PMID: 25477279; PMCID: PMC4396608.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    95. The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015; 10:395-424. Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. PMID: 25423351.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimals
    96. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15514-9. Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. PMID: 25313054; PMCID: PMC4217429.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansAnimalsCells
    97. cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700. Broderick L, Hoffman HM. PMID: 25045869.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    98. IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol. 2014 Aug 01; 193(3):1184-93. Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS. PMID: 24981452; PMCID: PMC4108541.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    99. NLRP3 inflammasome activation is required for fibrosis development in NAFLD. J Mol Med (Berl). 2014 Oct; 92(10):1069-82. Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. PMID: 24861026; PMCID: PMC4349416.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimals
    100. Possible cold autoinflammatory syndrome. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):642. Lieberman P, Hoffman HM. PMID: 25213069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    101. The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14. Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI. PMID: 24652041; PMCID: PMC4379507.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    102. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol. 2014 Apr 15; 192(8):3475-87. Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH. PMID: 24623133; PMCID: PMC3981544.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    103. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014 Mar; 59(3):898-910. Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE. PMID: 23813842; PMCID: PMC4008151.
      View in: PubMed   Mentions: 444     Fields:    Translation:HumansAnimalsCells
    104. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013 Nov; 123(11):4695-705. Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM. PMID: 24084736; PMCID: PMC3809806.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    105. Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry. Orphanet J Rare Dis. 2013 Sep 10; 8:139. Tilson H, Primatesta P, Kim D, Rauer B, Hawkins PN, Hoffman HM, Kuemmerle-Deschner J, van der Poll T, Walker UA. PMID: 24016338; PMCID: PMC3848430.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    106. Recurrent fevers and failure to thrive in an infant. Allergy Asthma Proc. 2013 Sep-Oct; 34(5):473-9. Scott DR, Chan S, Chang J, Broderick L, Hoffman HM. PMID: 23998246; PMCID: PMC8242986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    107. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.
      View in: PubMed   Mentions: 294     Fields:    Translation:Humans
    108. Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study. Clin Ther. 2012 Oct; 34(10):2091-103. Hoffman HM, Throne ML, Amar NJ, Cartwright RC, Kivitz AJ, Soo Y, Weinstein SP. PMID: 23031624.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCTClinical Trials
    109. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16648-53. Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide DH. PMID: 23011799; PMCID: PMC3478632.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    110. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. PMID: 22926405; PMCID: PMC3540165.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    111. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. PMID: 22904305; PMCID: PMC3495128.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    112. Guidelines for the genetic diagnosis of hereditary recurrent fevers. Ann Rheum Dis. 2012 Oct; 71(10):1599-605. Shinar Y, Obici L, Aksentijevich I, Bennetts B, Austrup F, Ceccherini I, Costa JM, De Leener A, Gattorno M, Kania U, Kone-Paut I, Lezer S, Livneh A, Moix I, Nishikomori R, Ozen S, Phylactou L, Risom L, Rowczenio D, Sarkisian T, van Gijn ME, Witsch-Baumgartner M, Morris M, Hoffman HM, Touitou I, European Molecular Genetics Quality Network. PMID: 22661645; PMCID: PMC3500529.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    113. Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity. J Autoimmun. 2012 Dec; 39(4):323-31. Pollard KM, Hultman P, Toomey CB, Cauvi DM, Hoffman HM, Hamel JC, Kono DH. PMID: 22578563; PMCID: PMC3570757.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    114. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. PMID: 22584197; PMCID: PMC3490505.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    115. Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice. PLoS One. 2012; 7(4):e35979. Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G. PMID: 22558291; PMCID: PMC3338787.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    116. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012 Feb 01; 482(7384):179-85. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. PMID: 22297845; PMCID: PMC3276682.
      View in: PubMed   Mentions: 1192     Fields:    Translation:Animals
    117. Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med. 2012 Jan 26; 366(4):330-8. Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O'Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, Milner JD. PMID: 22236196; PMCID: PMC3298368.
      View in: PubMed   Mentions: 179     Fields:    Translation:Humans
    118. Autoinflammation: translating mechanism to therapy. J Leukoc Biol. 2011 Jul; 90(1):37-47. Doherty TA, Brydges SD, Hoffman HM. PMID: 21330349; PMCID: PMC3219035.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    119. Genetic and molecular basis of inflammasome-mediated disease. J Biol Chem. 2011 Apr 01; 286(13):10889-96. Hoffman HM, Brydges SD. PMID: 21296874; PMCID: PMC3064144.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    120. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. PMID: 21220401; PMCID: PMC3025426.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    121. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20; 207(13):2799-807. González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. PMID: 21115691; PMCID: PMC3005235.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    122. An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol. 2010 Nov 15; 185(10):6277-85. Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia Jda S, Ulevitch RJ, Hoffman HM, McKay DB. PMID: 20962258; PMCID: PMC3020135.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    123. Inflammasome and IL-1beta-mediated disorders. Curr Allergy Asthma Rep. 2010 Jul; 10(4):229-35. Hoffman HM, Wanderer AA. PMID: 20425006; PMCID: PMC2892083.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    124. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum. 2010 Jul; 62(7):2170-9. Hoffman HM, Scott P, Mueller JL, Misaghi A, Stevens S, Yancopoulos GD, Murphy A, Valenzuela DM, Liu-Bryan R. PMID: 20506351; PMCID: PMC2929807.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    125. Therapy of autoinflammatory syndromes. J Allergy Clin Immunol. 2009 Dec; 124(6):1129-38; quiz 1139-40. Hoffman HM. PMID: 20004774; PMCID: PMC4508191.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    126. Familial atypical cold urticaria: description of a new hereditary disease. J Allergy Clin Immunol. 2009 Dec; 124(6):1245-50. Gandhi C, Healy C, Wanderer AA, Hoffman HM. PMID: 19910034; PMCID: PMC2794966.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    127. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol. 2009 Oct 05; 187(1):61-70. Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM. PMID: 19805629; PMCID: PMC2762099.
      View in: PubMed   Mentions: 450     Fields:    Translation:HumansAnimalsCells
    128. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 2009 Jun 19; 30(6):875-87. Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. PMID: 19501000; PMCID: PMC2759865.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    129. Recurrent febrile syndromes: what a rheumatologist needs to know. Nat Rev Rheumatol. 2009 May; 5(5):249-56. Hoffman HM, Simon A. PMID: 19412191.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    130. Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS). Expert Opin Biol Ther. 2009 Apr; 9(4):519-31. Hoffman HM. PMID: 19344287.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    131. NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem. 2009 May 08; 284(19):12762-71. Yamasaki K, Muto J, Taylor KR, Cogen AL, Audish D, Bertin J, Grant EP, Coyle AJ, Misaghi A, Hoffman HM, Gallo RL. PMID: 19258328; PMCID: PMC2676006.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    132. Initial description of the human NLRP3 promoter. Genes Immun. 2008 Dec; 9(8):721-6. Anderson JP, Mueller JL, Misaghi A, Anderson S, Sivagnanam M, Kolodner RD, Hoffman HM. PMID: 18719602; PMCID: PMC4477692.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    133. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum. 2008 Aug; 58(8):2443-52. Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N, Mellis SJ. PMID: 18668535.
      View in: PubMed   Mentions: 235     Fields:    Translation:Humans
    134. Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity. Curr Med Res Opin. 2008 Sep; 24(9):2531-43. Hoffman HM, Wolfe F, Belomestnov P, Mellis SJ. PMID: 18667113.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    135. The infevers autoinflammatory mutation online registry: update with new genes and functions. Hum Mutat. 2008 Jun; 29(6):803-8. Milhavet F, Cuisset L, Hoffman HM, Slim R, El-Shanti H, Aksentijevich I, Lesage S, Waterham H, Wise C, Sarrauste de Menthiere C, Touitou I. PMID: 18409191.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    136. Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology. 2008 Aug; 135(2):429-37. Sivagnanam M, Mueller JL, Lee H, Chen Z, Nelson SF, Turner D, Zlotkin SH, Pencharz PB, Ngan BY, Libiger O, Schork NJ, Lavine JE, Taylor S, Newbury RO, Kolodner RD, Hoffman HM. PMID: 18572020; PMCID: PMC2574708.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    137. The NLR gene family: a standard nomenclature. Immunity. 2008 Mar; 28(3):285-7. Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA. PMID: 18341998; PMCID: PMC2630772.
      View in: PubMed   Mentions: 434     Fields:    Translation:HumansAnimals
    138. Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe. 2007 Sep 13; 2(3):147-59. Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP. PMID: 18005730; PMCID: PMC2083260.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    139. Hereditary immunologic disorders caused by pyrin and cryopyrin. Curr Allergy Asthma Rep. 2007 Sep; 7(5):323-30. Hoffman HM. PMID: 17697637.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    140. Association between celiac sprue and cryopyrin associated autoinflammatory disorders: a case report. Pediatr Rheumatol Online J. 2007 Jun 05; 5:12. Shaker M, Edwards S, Chionuma H, Shamansky E, Hoffman HM. PMID: 17550587; PMCID: PMC1892774.
      View in: PubMed   Mentions: 3     Fields:    
    141. MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol. 2007 Jul; 82(1):177-83. Pan Q, Mathison J, Fearns C, Kravchenko VV, Da Silva Correia J, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ. PMID: 17403772.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    142. The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum. 2007 Apr; 56(4):1273-1285. Aksentijevich I, Putnam CD, Remmers EF, Mueller JL, Le J, Kolodner RD, Moak Z, Chuang M, Austin F, Goldbach-Mansky R, Hoffman HM, Kastner DL. PMID: 17393462; PMCID: PMC4321998.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansCells
    143. Successful treatment of renal amyloidosis due to familial cold autoinflammatory syndrome using an interleukin 1 receptor antagonist. Am J Kidney Dis. 2007 Mar; 49(3):477-81. Thornton BD, Hoffman HM, Bhat A, Don BR. PMID: 17336710.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    144. Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J Allergy Clin Immunol. 2007 Apr; 119(4):991-6. Rosengren S, Mueller JL, Anderson JP, Niehaus BL, Misaghi A, Anderson S, Boyle DL, Hoffman HM. PMID: 17320940; PMCID: PMC4322003.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    145. Response to IL-1-receptor antagonist in a child with familial cold autoinflammatory syndrome. Pediatr Dermatol. 2007 Jan-Feb; 24(1):85-9. O'Connell SM, O'Regan GM, Bolger T, Hoffman HM, Cant A, Irvine AD, Watson RM. PMID: 17300660.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    146. Anakinra for the treatment of neonatal-onset multisystem inflammatory disease. Nat Clin Pract Rheumatol. 2006 Dec; 2(12):646-7. Hoffman HM, Firestein GS. PMID: 17133246.
      View in: PubMed   Mentions: 5     Fields:    
    147. Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease. J Rheumatol. 2006 Oct; 33(10):2085-7. Metyas SK, Hoffman HM. PMID: 16981288.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    148. A severe case of chronic infantile neurologic, cutaneous, articular syndrome treated with biologic agents. Arthritis Rheum. 2006 Jul; 54(7):2314-20. Matsubara T, Hasegawa M, Shiraishi M, Hoffman HM, Ichiyama T, Tanaka T, Ueda H, Ishihara T, Furukawa S. PMID: 16802372.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    149. Familial Mediterranean fever (FMF) and beyond: a new horizon. Fourth International Congress on the Systemic Autoinflammatory Diseases held in Bethesda, USA, 6-10 November 2005. Ann Rheum Dis. 2006 Jul; 65(7):961-4. Ozen S, Hoffman HM, Frenkel J, Kastner D. PMID: 16606647; PMCID: PMC1798229.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    150. CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol. 2006 Mar; 6(3):183-95. Ting JP, Kastner DL, Hoffman HM. PMID: 16498449.
      View in: PubMed   Mentions: 135     Fields:    Translation:Humans
    151. Autoinflammatory syndromes. Clin Exp Rheumatol. 2006 Jan-Feb; 24(1 Suppl 40):S79-85. Galeazzi M, Gasbarrini G, Ghirardello A, Grandemange S, Hoffman HM, Manna R, Podswiadek M, Punzi L, Sebastiani GD, Touitou I, Doria A. PMID: 16466630.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    152. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol. 2005 Aug 15; 175(4):2630-4. Stack JH, Beaumont K, Larsen PD, Straley KS, Henkel GW, Randle JC, Hoffman HM. PMID: 16081838.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    153. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005 Jul 18; 202(2):209-15. Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastian JF, Fierer J, Nizet V. PMID: 16009720; PMCID: PMC2213009.
      View in: PubMed   Mentions: 315     Fields:    Translation:HumansAnimalsCells
    154. The clinical course of a child with CINCA/NOMID syndrome improved during and after treatment with thalidomide. Scand J Rheumatol. 2005 May-Jun; 34(3):246-9. Kallinich T, Hoffman HM, Roth J, Keitzer R. PMID: 16134734.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    155. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004 Nov 13-19; 364(9447):1779-85. Hoffman HM, Rosengren S, Boyle DL, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS. PMID: 15541451; PMCID: PMC4321997.
      View in: PubMed   Mentions: 200     Fields:    Translation:Humans
    156. Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium. Ann Rheum Dis. 2005 May; 64(5):708-14. Rosengren S, Hoffman HM, Bugbee W, Boyle DL. PMID: 15498798; PMCID: PMC1755498.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    157. Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18; 338(1):25-34. Anderson JP, Mueller JL, Rosengren S, Boyle DL, Schaner P, Cannon SB, Goodyear CS, Hoffman HM. PMID: 15302403; PMCID: PMC4348074.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    158. Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis. Genes Immun. 2004 Jun; 5(4):289-93. Aganna E, Hawkins PN, Ozen S, Pettersson T, Bybee A, McKee SA, Lachmann HJ, Karenko L, Ranki A, Bakkaloglu A, Besbas N, Topaloglu R, Hoffman HM, Hitman GA, Woo P, McDermott MF. PMID: 15071491.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    159. The spectrum of acquired and familial cold-induced urticaria/urticaria-like syndromes. Immunol Allergy Clin North Am. 2004 May; 24(2):259-86, vii. Wanderer AA, Hoffman HM. PMID: 15120151.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    160. A case of familial cold autoinflammatory syndrome confirmed by the presence of a CIAS1 mutation. Br J Dermatol. 2004 May; 150(5):1029-31. Shpall RL, Jeffes EW, Hoffman HM. PMID: 15149524.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    161. Genomic-based therapy: targeting interleukin-1 for autoinflammatory diseases. Arthritis Rheum. 2004 Feb; 50(2):345-9. Hoffman HM, Patel DD. PMID: 14872474.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    162. A large kindred with familial cold autoinflammatory syndrome. Ann Allergy Asthma Immunol. 2003 Feb; 90(2):233-7. Johnstone RF, Dolen WK, Hoffman HM. PMID: 12602672.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    163. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. PMID: 12507422.
      View in: PubMed   Mentions: 304     Fields:    Translation:HumansAnimalsCells
    164. Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet. 2003 Feb; 112(2):209-16. Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD. PMID: 12522564.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    165. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 2001 Nov; 29(3):301-5. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. PMID: 11687797; PMCID: PMC4322000.
      View in: PubMed   Mentions: 635     Fields:    Translation:HumansCells
    166. Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol. 2001 Oct; 108(4):615-20. Hoffman HM, Wanderer AA, Broide DH. PMID: 11590390; PMCID: PMC4321996.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    167. Humoral immunodeficiency with facial dysmorphology and limb anomalies: a new syndrome. Clin Dysmorphol. 2001 Jan; 10(1):1-8. Hoffman HM, Bastian JF, Bird LM. PMID: 11152140.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    168. Development of an experimental paradigm in which to examine human learning using two computer-based formats. Stud Health Technol Inform. 2001; 81:187-91. Hoffman HM, Colt HG, Haas A. PMID: 11317737.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    169. Identification of a locus on chromosome 1q44 for familial cold urticaria. Am J Hum Genet. 2000 May; 66(5):1693-8. Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD. PMID: 10741953; PMCID: PMC1378006.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    170. Mast cell adenosine induced calcium mobilization via Gi3 and Gq proteins. Inflammation. 1997 Feb; 21(1):55-68. Hoffman HM, Walker LL, Marquardt DL. PMID: 9179622.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    171. Developing a virtual reality-multimedia system for anatomy training. Stud Health Technol Inform. 1996; 29:204-10. Hoffman HM, Murray M, Irwin AE, McCracken T. PMID: 10163751.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    Hal's Networks
    Concepts (695)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (110)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (59)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-16-gff1bd585 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California