Igor Tsigelny

Title(s)Emeritus Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. miRNA in Machine-Learning-Based Diagnostics of Oral Cancer. Biomedicines. 2024 Oct 21; 12(10). Li X, Kouznetsova VL, Tsigelny IF. PMID: 39457716; PMCID: PMC11504892.
      View in: PubMed   Mentions:
    2. Implementation of Machine Learning-Based System for Early Diagnosis of Feline Mammary Carcinomas through Blood Metabolite Profiling. Metabolites. 2024 Sep 17; 14(9). Kulkarni V, Tsigelny IF, Kouznetsova VL. PMID: 39330508; PMCID: PMC11433869.
      View in: PubMed   Mentions:
    3. piRNA in Machine-Learning-Based Diagnostics of Colorectal Cancer. Molecules. 2024 Sep 11; 29(18). Li S, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 39339306; PMCID: PMC11434383.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Development of a Diagnostic Model for Pancreatic Ductal Adenocarcinoma Using Machine Learning and Blood-Based miRNAs. Oncology. 2024 Sep 04; 1-10. Tang JY, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 39231457.
      View in: PubMed   Mentions:    Fields:    
    5. Fibrin drives thromboinflammation and neuropathology in COVID-19. Nature. 2024 Sep; 633(8031):905-913. Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K. PMID: 39198643; PMCID: PMC11424477.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Using Machine Learning and miRNA for the Diagnosis of Esophageal Cancer. J Appl Lab Med. 2024 Jul 01; 9(4):684-695. Aravind VA, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 38721901.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Colorectal Cancer Detection via Metabolites and Machine Learning. Curr Issues Mol Biol. 2024 Apr 30; 46(5):4133-4146. Yang R, Tsigelny IF, Kesari S, Kouznetsova VL. PMID: 38785522; PMCID: PMC11119033.
      View in: PubMed   Mentions:    Fields:    
    8. Parkinson's Disease Diagnosis Using miRNA Biomarkers and Deep Learning. Front Biosci (Landmark Ed). 2024 01 12; 29(1):4. Kumar A, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 38287819.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Laryngeal cancer diagnosis via miRNA-based decision tree model. Eur Arch Otorhinolaryngol. 2024 Mar; 281(3):1391-1399. Arora A, Tsigelny IF, Kouznetsova VL. PMID: 38147113.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Diagnostics of Thyroid Cancer Using Machine Learning and Metabolomics. Metabolites. 2023 Dec 22; 14(1). Kuang A, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 38248814; PMCID: PMC10818630.
      View in: PubMed   Mentions: 1  
    11. Small molecular decoys in Alzheimer's disease. Neural Regen Res. 2024 Aug 01; 19(8):1658-1659. Oasa S, Kouznetsova VL, Tsigelny IF, Terenius L. PMID: 38103228; PMCID: PMC10960305.
      View in: PubMed   Mentions:
    12. Role of Senataxin in Amyotrophic Lateral Sclerosis. J Mol Neurosci. 2023 Dec; 73(11-12):996-1009. Tsui A, Kouznetsova VL, Kesari S, Fiala M, Tsigelny IF. PMID: 37982993.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Synergism in actions of HBV with aflatoxin in cancer development. Toxicology. 2023 11; 499:153652. Jin J, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 37858775.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Two-Stage Deep-Learning Classifier for Diagnostics of Lung Cancer Using Metabolites. Metabolites. 2023 Oct 07; 13(10). Choudhary A, Yu J, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 37887380; PMCID: PMC10609149.
      View in: PubMed   Mentions:
    15. Search of inhibitors of aldose reductase for treatment of diabetic cataracts using machine learning. Adv Ophthalmol Pract Res. 2023 Nov-Dec; 3(4):187-191. Chen T, Chen R, You A, Kouznetsova VL, Tsigelny IF. PMID: 37928946; PMCID: PMC10624573.
      View in: PubMed   Mentions: 1  
    16. Targeting of insulin receptor endocytosis as a treatment to insulin resistance. J Diabetes Complications. 2023 11; 37(11):108615. Tim B, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 37788593.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Biological functions of the Olig gene family in brain cancer and therapeutic targeting. Front Neurosci. 2023; 17:1129434. Szu JI, Tsigelny IF, Wojcinski A, Kesari S. PMID: 37274223; PMCID: PMC10232966.
      View in: PubMed   Mentions: 3  
    18. Small Molecule Decoys of Aggregation for Elimination of Aβ-Peptide Toxicity. ACS Chem Neurosci. 2023 05 03; 14(9):1575-1584. Oasa S, Kouznetsova VL, Tiiman A, Vukojevic V, Tsigelny IF, Terenius L. PMID: 37058367; PMCID: PMC10161222.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    19. Diagnostics of ovarian cancer via metabolite analysis and machine learning. Integr Biol (Camb). 2023 04 11; 15. Yao JZ, Tsigelny IF, Kesari S, Kouznetsova VL. PMID: 37032481.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning. Med Drug Discov. 2023 Feb; 17:100148. Gantla MR, Tsigelny IF, Kouznetsova VL. PMID: 36466363; PMCID: PMC9706997.
      View in: PubMed   Mentions: 4  
    21. Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern. PLoS Pathog. 2022 07; 18(7):e1010686. Almanza G, Clark AE, Kouznetsova V, Olmedillas E, Castro A, Tsigelny IF, Wu Y, Gao GF, Leibel SL, Bray W, Ollmann Saphire E, Carlin AF, Zanetti M. PMID: 35862442; PMCID: PMC9302722.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    22. The role of BAG3 in dilated cardiomyopathy and its association with Charcot-Marie-Tooth disease type 2. Acta Myol. 2022 Jun; 41(2):59-75. Yerabandi N, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 35832504; PMCID: PMC9237749.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Machine-learning-based virtual screening to repurpose drugs for treatment of Candida albicans infection. Mycoses. 2022 Aug; 65(8):794-805. Gao A, Kouznetsova VL, Tsigelny IF. PMID: 35639510.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Potential SARS-CoV-2 nonstructural proteins inhibitors: drugs repurposing with drug-target networks and deep learning. Front Biosci (Landmark Ed). 2022 04 01; 27(4):113. Azmoodeh SK, Tsigelny IF, Kouznetsova VL. PMID: 35468672.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    25. Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds. J Mol Model. 2022 Mar 12; 28(4):89. Zhang A, Teigen K, Kouznetsova VL, Tsigelny IF. PMID: 35279789.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Alzheimer's Disease Diagnostics Using miRNA Biomarkers and Machine Learning. J Alzheimers Dis. 2022; 86(2):841-859. Xu A, Kouznetsova VL, Tsigelny IF. PMID: 35147545.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Implications of viral infection in cancer development. Biochim Biophys Acta Rev Cancer. 2021 12; 1876(2):188622. Kellogg C, Kouznetsova VL, Tsigelny IF. PMID: 34478803.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Dynamic Cellular Cartography: Mapping the Local Determinants of Oligodendrocyte Transcription Factor 2 (OLIG2) Function in Live Cells Using Massively Parallel Fluorescence Correlation Spectroscopy Integrated with Fluorescence Lifetime Imaging Microscopy (mpFCS/FLIM). Anal Chem. 2021 09 07; 93(35):12011-12021. Oasa S, Krmpot AJ, Nikolic SN, Clayton AHA, Tsigelny IF, Changeux JP, Terenius L, Rigler R, Vukojevic V. PMID: 34428029; PMCID: PMC8427561.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    29. Potential SARS-CoV-2 protease Mpro inhibitors: repurposing FDA-approved drugs. Phys Biol. 2021 02 09; 18(2):025001. Kouznetsova VL, Huang DZ, Tsigelny IF. PMID: 33203811.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Interactions of large T-Antigen (LT) protein of polyomaviruses with p53 unfold their cancerogenic potential. J Biomol Struct Dyn. 2022 07; 40(11):5243-5252. Kellogg C, Kouznetsova VL, Tsigelny IF. PMID: 33416027.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    31. Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs. PeerJ. 2020; 8:e9965. Kouznetsova VL, Zhang A, Tatineni M, Miller MA, Tsigelny IF. PMID: 32999768; PMCID: PMC7505060.
      View in: PubMed   Mentions: 30     Fields:    
    32. Finding distinctions between oral cancer and periodontitis using saliva metabolites and machine learning. Oral Dis. 2021 Apr; 27(3):484-493. Kouznetsova VL, Li J, Romm E, Tsigelny IF. PMID: 32762095.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    33. Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning. Molecules. 2020 Aug 26; 25(17). Wang K, Romm EL, Kouznetsova VL, Tsigelny IF. PMID: 32858918; PMCID: PMC7503396.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials. Int J Cancer. 2020 11 01; 147(9):2537-2549. Schperberg AV, Boichard A, Tsigelny IF, Richard SB, Kurzrock R. PMID: 32745254.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. Bovine leukemia virus relation to human breast cancer: Meta-analysis. Microb Pathog. 2020 Dec; 149:104417. Gao A, Kouznetsova VL, Tsigelny IF. PMID: 32731009; PMCID: PMC7384413.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. Deep-learning- and pharmacophore-based prediction of RAGE inhibitors. Phys Biol. 2020 03 16; 17(3):036003. Huang DZ, Kouznetsova VL, Tsigelny IF. PMID: 31905346.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. A strategy for designing allosteric modulators of transcription factor dimerization. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2683-2686. Oasa S, Vukojevic V, Rigler R, Tsigelny IF, Changeux JP, Terenius L. PMID: 31953259; PMCID: PMC7007557.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    38. Artificial Intelligence in Drug Treatment. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:353-369. Romm EL, Tsigelny IF. PMID: 31348869.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    39. ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly. J Biol Chem. 2019 09 27; 294(39):14454-14466. Hayward D, Kouznetsova VL, Pierson HE, Hasan NM, Guzman ER, Tsigelny IF, Lutsenko S. PMID: 31337707; PMCID: PMC6768640.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. Artificial intelligence in drug combination therapy. Brief Bioinform. 2019 07 19; 20(4):1434-1448. Tsigelny IF. PMID: 29438494.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    41. Recognition of early and late stages of bladder cancer using metabolites and machine learning. Metabolomics. 2019 06 20; 15(7):94. Kouznetsova VL, Kim E, Romm EL, Zhu A, Tsigelny IF. PMID: 31222577.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    42. Polycomb repressive 2 complex-Molecular mechanisms of function. Protein Sci. 2019 08; 28(8):1387-1399. Kouznetsova VL, Tchekanov A, Li X, Yan X, Tsigelny IF. PMID: 31095801; PMCID: PMC6635771.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    43. APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. Oncoimmunology. 2019; 8(3):1550341. Boichard A, Pham TV, Yeerna H, Goodman A, Tamayo P, Lippman S, Frampton GM, Tsigelny IF, Kurzrock R. PMID: 30723579; PMCID: PMC6350681.
      View in: PubMed   Mentions: 40     Fields:    
    44. In Vitro Elucidation of Drug Combination Synergy in Treatment of Pancreatic Ductal Adenocarcinoma. Anticancer Res. 2018 04; 38(4):1967-1977. Bush KT, Boichard A, Tsigelny IF. PMID: 29599312.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. Oncologist. 2018 05; 23(5):586-593. Ikeda S, Tsigelny IF, Skjevik ÅA, Kono Y, Mendler M, Kuo A, Sicklick JK, Heestand G, Banks KC, Talasaz A, Lanman RB, Lippman S, Kurzrock R. PMID: 29487225; PMCID: PMC5947459.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    46. Cripto stabilizes GRP78 on the cell membrane. Protein Sci. 2018 03; 27(3):653-661. Kouznetsova VL, Hu H, Teigen K, Zanetti M, Tsigelny IF. PMID: 29226519; PMCID: PMC5818753.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    47. Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer. Cancer Discov. 2018 02; 8(2):164-173. Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, Corcoran RB, Kopetz S. PMID: 29196463; PMCID: PMC5809260.
      View in: PubMed   Mentions: 132     Fields:    Translation:Humans
    48. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma. J Transl Med. 2017 10 18; 15(1):210. Yenugonda V, Nomura N, Kouznetsova V, Tsigelny I, Fogal V, Nurmemmedov E, Kesari S, Babic I. PMID: 29047383; PMCID: PMC5648515.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    49. BRAF mutation as a novel driver of eosinophilic cystitis. Cancer Biol Ther. 2017 Sep 02; 18(9):655-659. Choi MY, Tsigelny IF, Boichard A, Skjevik ÅA, Shabaik A, Kurzrock R. PMID: 28829677; PMCID: PMC5663411.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    50. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384. Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. PMID: 26517684; PMCID: PMC5410230.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    51. High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations. Oncoimmunology. 2017; 6(3):e1284719. Boichard A, Tsigelny IF, Kurzrock R. PMID: 28405512; PMCID: PMC5384346.
      View in: PubMed   Mentions: 47     Fields:    
    52. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481; PMCID: PMC5840882.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    53. Molecular mechanisms of OLIG2 transcription factor in brain cancer. Oncotarget. 2016 Aug 16; 7(33):53074-53101. Tsigelny IF, Kouznetsova VL, Lian N, Kesari S. PMID: 27447975; PMCID: PMC5288170.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    54. Cisplatin inhibits MEK1/2. Oncotarget. 2015 Sep 15; 6(27):23510-22. Yamamoto T, Tsigelny IF, Götz AW, Howell SB. PMID: 26155939; PMCID: PMC4695133.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    55. The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). Metallomics. 2015 Nov; 7(11):1477-87. Tsai CY, Liebig JK, Tsigelny IF, Howell SB. PMID: 26205368; PMCID: PMC4635045.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    56. Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma. Mol Biosyst. 2015 Apr; 11(4):1012-28. Tsigelny IF, Kouznetsova VL, Jiang P, Pingle SC, Kesari S. PMID: 25648506.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer. Oncotarget. 2015 Mar 20; 6(8):6029-39. Tsigelny IF, Wheler JJ, Greenberg JP, Kouznetsova VL, Stewart DJ, Bazhenova L, Kurzrock R. PMID: 25760241; PMCID: PMC4467419.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    58. Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023; PMCID: PMC4944825.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    59. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211; PMCID: PMC4290715.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    60. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184; PMCID: PMC4250372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    61. bHLH Transcription factors inhibitors for cancer therapy: general features for in silico drug design. Curr Med Chem. 2014; 21(28):3227-43. Tsigelny IF, Kouznetsova VL, Pingle SC, Kesari S. PMID: 24735358.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    62. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640; PMCID: PMC4449729.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    63. Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Bioorg Med Chem. 2013 Sep 15; 21(18):5855-69. Tsigelny IF, Kouznetsova VL, Biswas N, Mahata SK, O'Connor DT. PMID: 23916146.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    64. p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19; 33(25):10221-34. Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny IF, Sassone-Corsi P, Ptácek LJ, Akassoglou K. PMID: 23785138; PMCID: PMC3685830.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    65. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327; PMCID: PMC3722616.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    66. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano. 2013 May 28; 7(5):4289-98. Chao Y, Karmali PP, Mukthavaram R, Kesari S, Kouznetsova VL, Tsigelny IF, Simberg D. PMID: 23614696.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    67. A hierarchical coherent-gene-group model for brain development. Genes Brain Behav. 2013 Mar; 12(2):147-65. Tsigelny IF, Kouznetsova VL, Baitaluk M, Changeux JP. PMID: 23173912.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    68. An all-atom model of the structure of human copper transporter 1. Cell Biochem Biophys. 2012 Jul; 63(3):223-34. Tsigelny IF, Sharikov Y, Greenberg JP, Miller MA, Kouznetsova VL, Larson CA, Howell SB. PMID: 22569840; PMCID: PMC3590913.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    69. Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9. Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. PMID: 22515422; PMCID: PMC3444675.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    70. Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432; PMCID: PMC3925782.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    71. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. PMID: 21499753.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    72. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem. 2011 Jun 01; 19(11):3320-40. Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam SK. PMID: 21571536; PMCID: PMC3310230.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    73. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011 Jun 03; 10(6):2842-51. Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK. PMID: 21476605; PMCID: PMC3201759.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    74. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. PMID: 21045796; PMCID: PMC4996353.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    75. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. PMID: 20978615; PMCID: PMC2956464.
      View in: PubMed   Mentions:
    76. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. PMID: 20154271; PMCID: PMC2840076.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    77. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C496-509. Burg ED, Platoshyn O, Tsigelny IF, Lozano-Ruiz B, Rana BK, Yuan JX. PMID: 20018952; PMCID: PMC2838577.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    78. Interaction of organic cations with organic anion transporters. J Biol Chem. 2009 Nov 06; 284(45):31422-30. Ahn SY, Eraly SA, Tsigelny I, Nigam SK. PMID: 19737926; PMCID: PMC2781538.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    79. Role of synucleins in Alzheimer's disease. Neurotox Res. 2009 Oct; 16(3):306-17. Crews L, Tsigelny I, Hashimoto M, Masliah E. PMID: 19551456; PMCID: PMC2727399.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    80. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008 Dec 09; 1(49):ra16. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam SK. PMID: 19066399; PMCID: PMC3016920.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    81. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol. 2008 Oct; 6(5):885-904. Tsigelny IF, Greenberg J, Kouznetsova V, Nigam SK. PMID: 18942157; PMCID: PMC2676871.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    82. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546; PMCID: PMC2519786.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    83. Thermal denaturation of wild type and mutant recombinant acetylcholinesterase from amphioxus: effects of the temperature of in vitro expression and of reversible inhibitors. Invert Neurosci. 2008 Sep; 8(3):147-55. Perrin B, Rowland M, Wolfe M, Tsigelny I, Pezzementi L. PMID: 18677525; PMCID: PMC2574716.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    84. Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies. Nanomedicine. 2008 Dec; 4(4):350-7. Tsigelny IF, Sharikov Y, Miller MA, Masliah E. PMID: 18640077; PMCID: PMC2627560.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    85. Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: a reconsideration of the implications for insecticide design. Chem Biol Interact. 2008 Sep 25; 175(1-3):73-5. Rowland M, Tsigelny I, Wolfe M, Pezzementi L. PMID: 18384763; PMCID: PMC2571039.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    86. Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide. FEBS J. 2008 Mar; 275(6):1309-22. Frederick A, Tsigelny I, Cohenour F, Spiker C, Krejci E, Chatonnet A, Bourgoin S, Richards G, Allen T, Whitlock MH, Pezzementi L. PMID: 18279391.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    87. MAPAS: a tool for predicting membrane-contacting protein surfaces. Nat Methods. 2008 Feb; 5(2):119. Sharikov Y, Walker RC, Greenberg J, Kouznetsova V, Nigam SK, Miller MA, Masliah E, Tsigelny IF. PMID: 18235431.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    88. Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). Biol Cell. 2007 Aug; 99(8):433-44. Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH. PMID: 17388782.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    89. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol. 2007 Jun 18; 177(6):1119-32. Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. PMID: 17576803; PMCID: PMC2064370.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    90. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure. 2007 Jun; 15(6):693-705. Comoletti D, Grishaev A, Whitten AE, Tsigelny I, Taylor P, Trewhella J. PMID: 17562316; PMCID: PMC2677967.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    91. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77. Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. PMID: 17381514.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    92. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem. 2007; 14(27):2925-36. Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. PMID: 18045138.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    93. The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state. J Bacteriol. 2006 Jul; 188(13):4970-7. Varughese KI, Tsigelny I, Zhao H. PMID: 16788205; PMCID: PMC1482986.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    94. Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem. 2006 Aug 25; 281(34):24678-86. Talley TT, Olivera BM, Han KH, Christensen SB, Dowell C, Tsigelny I, Ho KY, Taylor P, McIntosh JM. PMID: 16803900; PMCID: PMC4762451.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    95. Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: the roles of two cysteines in the catalytic gorge of the enzyme. Invert Neurosci. 2006 Jun; 6(2):47-55. Pezzementi L, Rowland M, Wolfe M, Tsigelny I. PMID: 16586114.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    96. A tryptophan in the bottleneck of the catalytic gorge of an invertebrate acetylcholinesterase confers relative resistance to carbamate and organophosphate inhibitors. Cell Biochem Biophys. 2006; 46(3):253-64. Patel R, Sanders R, Brown L, Baker S, Tsigelny I, Pezzementi L. PMID: 17272851.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    97. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem. 2005 Jun 10; 280(23):22365-74. Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC. PMID: 15797875.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    98. Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis. Cell Biochem Biophys. 2005; 42(1):41-53. Tsigelny I, Hotchko M, Yuan JX, Keller SH. PMID: 15673927.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    99. Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma. J Biomed Biotechnol. 2005; 2005(4):353-63. Tsigelny I, Burton DW, Sharikov Y, Hastings RH, Deftos LJ. PMID: 16489268; PMCID: PMC1361488.
      View in: PubMed   Mentions: 1     Fields:    
    100. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci. 2004 May 19; 24(20):4889-93. Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. PMID: 15152050; PMCID: PMC6729460.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    101. Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. Regul Pept. 2004 Apr 15; 118(1-2):75-87. Preece NE, Nguyen M, Mahata M, Mahata SK, Mahapatra NR, Tsigelny I, O'Connor DT. PMID: 14759560.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    102. SNP analysis combined with protein structure prediction defines structure-functional relationships in cancer related cytochrome P450 estrogen metabolism. Curr Med Chem. 2004 Mar; 11(5):525-38. Tsigelny IF, Kotlovyi V, Wasserman L. PMID: 15032601.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    103. Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry. 2004 Feb 17; 43(6):1496-506. Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor P. PMID: 14769026.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    104. Complex dynamics of chaperone-protein interactions under cellular stress. Cell Biochem Biophys. 2004; 40(3):263-76. Tsigelny IF, Nigam SK. PMID: 15211027.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    105. Amino acids defining the acyl pocket of an invertebrate cholinesterase. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec; 136(4):813-32. Pezzementi L, Johnson K, Tsigelny I, Cotney J, Manning E, Barker A, Merritt S. PMID: 14662305.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    106. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. PMID: 14583592; PMCID: PMC263775.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    107. Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information. Proteins. 2003 Jul 01; 52(1):33-40. Law DS, Ten Eyck LF, Katzenelson O, Tsigelny I, Roberts VA, Pique ME, Mitchell JC. PMID: 12784365.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    108. Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein. J Biol Chem. 2002 Nov 01; 277(44):41299-302. Hansen SB, Radic' Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, Taylor P. PMID: 12235129; PMCID: PMC3191908.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    109. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site. Biochemistry. 2002 Jun 25; 41(25):7895-906. Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. PMID: 12069578.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    110. Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information. Protein Eng. 2002 May; 15(5):347-52. Tsigelny I, Sharikov Y, Ten Eyck LF. PMID: 12034853.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    111. Electrostatic environment surrounding the activation loop phosphotyrosine in the oncoprotein v-Fps. Biochemistry. 2001 Aug 28; 40(34):10078-86. Leon BC, Tsigelny I, Adams JA. PMID: 11513586.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    112. Protein docking using continuum electrostatics and geometric fit. Protein Eng. 2001 Feb; 14(2):105-13. Mandell JG, Roberts VA, Pique ME, Kotlovyi V, Mitchell JC, Nelson E, Tsigelny I, Ten Eyck LF. PMID: 11297668.
      View in: PubMed   Mentions: 100     Fields:    Translation:Cells
    113. Catalytic assessment of the glycine-rich loop of the v-Fps oncoprotein using site-directed mutagenesis. Biochemistry. 2000 Oct 31; 39(43):13276-84. Hirai TJ, Tsigelny I, Adams JA. PMID: 11052681.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    114. Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure. Pflugers Arch. 2000; 440(5 Suppl):R115-7. Taylor P, Malanz S, Molles BE, Osaka H, Tsigelny I. PMID: 11005635.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    115. Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations. Protein Sci. 2000 Jan; 9(1):180-5. Tsigelny I, Shindyalov IN, Bourne PE, Südhof TC, Taylor P. PMID: 10739260; PMCID: PMC2144444.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    116. Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure. Pflugers Arch. 2000 Jan; 440(Suppl 1):R115-R117. Taylor P, Malany S, Molles BE, Osaka H, Tsigelny I. PMID: 28008504.
      View in: PubMed   Mentions: 1     Fields:    
    117. 600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers. 1999 Oct 15; 50(5):513-24. Tsigelny I, Greenberg JP, Cox S, Nichols WL, Taylor SS, Ten Eyck LF. PMID: 10479734.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    118. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity. Chem Biol Interact. 1999 May 14; 119-120:3-15. Taylor P, Wong L, Radic Z, Tsigelny I, Brüggemann R, Hosea NA, Berman HA. PMID: 10421434.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    119. Delineation of selective cyclic GMP-dependent protein kinase Ialpha substrate and inhibitor peptides based on combinatorial peptide libraries on paper. Pharmacol Ther. 1999 May-Jun; 82(2-3):373-87. Dostmann WR, Nickl C, Thiel S, Tsigelny I, Frank R, Tegge WJ. PMID: 10454213.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    120. Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity. Regul Pept. 1998 Oct 16; 77(1-3):43-53. Tsigelny I, Mahata SK, Taupenot L, Preece NE, Mahata M, Khan I, Parmer RJ, O'Connor DT. PMID: 9809795; PMCID: PMC3676947.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    121. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry. 1998 May 26; 37(21):7708-15. Grant BD, Hemmer W, Tsigelny I, Adams JA, Taylor SS. PMID: 9601030.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    122. Identification of pairwise interactions in the alpha-neurotoxin-nicotinic acetylcholine receptor complex through double mutant cycles. J Biol Chem. 1998 May 01; 273(18):10958-64. Ackermann EJ, Ang ET, Kanter JR, Tsigelny I, Taylor P. PMID: 9556574.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    123. Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure. J Physiol Paris. 1998 Apr; 92(2):79-83. Taylor P, Osaka H, Molles BE, Sugiyama N, Marchot P, Ackermann EJ, Malany S, McArdle JJ, Sine SM, Tsigelny I. PMID: 9782448.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    124. Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. J Biol Chem. 1997 Jul 04; 272(27):16946-54. Hemmer W, McGlone M, Tsigelny I, Taylor SS. PMID: 9202006.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    125. A model of the nicotinic receptor extracellular domain based on sequence identity and residue location. Biophys J. 1997 Jul; 73(1):52-66. Tsigelny I, Sugiyama N, Sine SM, Taylor P. PMID: 9199771; PMCID: PMC1180908.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    126. Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics. J Pept Res. 1997 Mar; 49(3):210-20. Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS. PMID: 9151254.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    127. Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy. J Biol Chem. 1997 Jan 17; 272(3):1507-13. Lew J, Coruh N, Tsigelny I, Garrod S, Taylor SS. PMID: 8999821.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    128. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4):249-60. Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. PMID: 9676269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    129. Structures important in NAD(P)(H) specificity for mammalian retinol and 11-Cis-retinol dehydrogenases. Biochem Biophys Res Commun. 1996 Sep 04; 226(1):118-27. Tsigelny I, Baker ME. PMID: 8806601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    130. Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition. Biopolymers. 1996 Sep; 39(3):353-65. Tsigelny I, Grant BD, Taylor SS, Ten Eyck LF. PMID: 8756515.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    131. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry. 1996 Aug 20; 35(33):10995-1004. Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. PMID: 8718893.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    132. Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit. Protein Sci. 1996 Jul; 5(7):1316-24. Grant BD, Tsigelny I, Adams JA, Taylor SS. PMID: 8819164; PMCID: PMC2143462.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    133. Structures stabilizing the dimer interface on human 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase and their homologs. Biochem Biophys Res Commun. 1995 Dec 26; 217(3):859-68. Tsigelny I, Baker ME. PMID: 8554609.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    134. Structures important in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol. 1995 Dec; 55(5-6):589-600. Tsigelny I, Baker ME. PMID: 8547186.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    135. Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. Biochem J. 1995 Jun 01; 308 ( Pt 2):419-23. Chenevert SW, Fossett NG, Chang SH, Tsigelny I, Baker ME, Lee WR. PMID: 7772022; PMCID: PMC1136942.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    136. Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase. Protein Sci. 1995 Apr; 4(4):703-15. van den Born HK, Radic Z, Marchot P, Taylor P, Tsigelny I. PMID: 7613468; PMCID: PMC2143104.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    137. Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. J Biol Chem. 1995 Mar 17; 270(11):6370-80. Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P. PMID: 7890775.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    138. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 1994 Dec 15; 8(24):2996-3007. Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. PMID: 8001819.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCells
    139. Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. FEBS Lett. 1994 Dec 12; 356(1):81-5. Chen Z, Tsigelny I, Lee WR, Baker ME, Chang SH. PMID: 7988726.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    140. Protein kinases share a common structural motif outside the conserved catalytic domain. Cell Mol Biol (Noisy-le-grand). 1994 Jul; 40(5):587-96. Véron M, Radzio-Andzelm E, Tsigelny I, Taylor S. PMID: 7981616.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    141. A conserved helix motif complements the protein kinase core. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10618-22. Veron M, Radzio-Andzelm E, Tsigelny I, Ten Eyck LF, Taylor SS. PMID: 7504272; PMCID: PMC47828.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
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