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Igor Tsigelny

Title(s)Emeritus Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs. PeerJ. 2020; 8:e9965. Kouznetsova VL, Zhang A, Tatineni M, Miller MA, Tsigelny IF. PMID: 32999768.
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    2. Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning. Molecules. 2020 Aug 26; 25(17). Wang K, Romm EL, Kouznetsova VL, Tsigelny IF. PMID: 32858918.
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    3. Finding distinctions between oral cancer and periodontitis using saliva metabolites and machine learning. Oral Dis. 2020 Aug 06. Kouznetsova VL, Li J, Romm E, Tsigelny IF. PMID: 32762095.
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    4. Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials. Int J Cancer. 2020 Aug 03. Schperberg AV, Boichard A, Tsigelny IF, Richard SB, Kurzrock R. PMID: 32745254.
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    5. Bovine leukemia virus relation to human breast cancer: Meta-analysis. Microb Pathog. 2020 Jul 27; 149:104417. Gao A, Kouznetsova VL, Tsigelny IF. PMID: 32731009.
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    6. Deep-learning- and pharmacophore-based prediction of RAGE inhibitors. Phys Biol. 2020 03 16; 17(3):036003. Huang DZ, Kouznetsova VL, Tsigelny IF. PMID: 31905346.
      View in: PubMed   Mentions: 1     Fields:    
    7. A strategy for designing allosteric modulators of transcription factor dimerization. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2683-2686. Oasa S, Vukojevic V, Rigler R, Tsigelny IF, Changeux JP, Terenius L. PMID: 31953259.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Artificial Intelligence in Drug Treatment. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:353-369. Romm EL, Tsigelny IF. PMID: 31348869.
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    9. ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly. J Biol Chem. 2019 09 27; 294(39):14454-14466. Hayward D, Kouznetsova VL, Pierson HE, Hasan NM, Guzman ER, Tsigelny IF, Lutsenko S. PMID: 31337707.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Artificial intelligence in drug combination therapy. Brief Bioinform. 2019 07 19; 20(4):1434-1448. Tsigelny IF. PMID: 29438494.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Recognition of early and late stages of bladder cancer using metabolites and machine learning. Metabolomics. 2019 06 20; 15(7):94. Kouznetsova VL, Kim E, Romm EL, Zhu A, Tsigelny IF. PMID: 31222577.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Polycomb repressive 2 complex-Molecular mechanisms of function. Protein Sci. 2019 08; 28(8):1387-1399. Kouznetsova VL, Tchekanov A, Li X, Yan X, Tsigelny IF. PMID: 31095801.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    13. APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. Oncoimmunology. 2019; 8(3):1550341. Boichard A, Pham TV, Yeerna H, Goodman A, Tamayo P, Lippman S, Frampton GM, Tsigelny IF, Kurzrock R. PMID: 30723579.
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    14. In Vitro Elucidation of Drug Combination Synergy in Treatment of Pancreatic Ductal Adenocarcinoma. Anticancer Res. 2018 04; 38(4):1967-1977. Bush KT, Boichard A, Tsigelny IF. PMID: 29599312.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. Oncologist. 2018 05; 23(5):586-593. Ikeda S, Tsigelny IF, Skjevik ÅA, Kono Y, Mendler M, Kuo A, Sicklick JK, Heestand G, Banks KC, Talasaz A, Lanman RB, Lippman S, Kurzrock R. PMID: 29487225.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    16. Cripto stabilizes GRP78 on the cell membrane. Protein Sci. 2018 03; 27(3):653-661. Kouznetsova VL, Hu H, Teigen K, Zanetti M, Tsigelny IF. PMID: 29226519.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer. Cancer Discov. 2018 02; 8(2):164-173. Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, Corcoran RB, Kopetz S. PMID: 29196463.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    18. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma. J Transl Med. 2017 10 18; 15(1):210. Yenugonda V, Nomura N, Kouznetsova V, Tsigelny I, Fogal V, Nurmemmedov E, Kesari S, Babic I. PMID: 29047383.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. BRAF mutation as a novel driver of eosinophilic cystitis. . 2017 Sep 02; 18(9):655-659. Choi MY, Tsigelny IF, Boichard A, Skjevik ÅA, Shabaik A, Kurzrock R. PMID: 28829677.
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    20. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384. Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. PMID: 26517684.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations. Oncoimmunology. 2017; 6(3):e1284719. Boichard A, Tsigelny IF, Kurzrock R. PMID: 28405512.
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    22. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    23. Molecular mechanisms of OLIG2 transcription factor in brain cancer. Oncotarget. 2016 Aug 16; 7(33):53074-53101. Tsigelny IF, Kouznetsova VL, Lian N, Kesari S. PMID: 27447975.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Cisplatin inhibits MEK1/2. Oncotarget. 2015 Sep 15; 6(27):23510-22. Yamamoto T, Tsigelny IF, Götz AW, Howell SB. PMID: 26155939.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). Metallomics. 2015 Nov; 7(11):1477-87. Tsai CY, Liebig JK, Tsigelny IF, Howell SB. PMID: 26205368.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma. Mol Biosyst. 2015 Apr; 11(4):1012-28. Tsigelny IF, Kouznetsova VL, Jiang P, Pingle SC, Kesari S. PMID: 25648506.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer. Oncotarget. 2015 Mar 20; 6(8):6029-39. Tsigelny IF, Wheler JJ, Greenberg JP, Kouznetsova VL, Stewart DJ, Bazhenova L, Kurzrock R. PMID: 25760241.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    28. Molecular determinants of a-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    30. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. bHLH Transcription factors inhibitors for cancer therapy: general features for in silico drug design. Curr Med Chem. 2014; 21(28):3227-43. Tsigelny IF, Kouznetsova VL, Pingle SC, Kesari S. PMID: 24735358.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    32. Structural diversity of Alzheimer's disease amyloid-ß dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Bioorg Med Chem. 2013 Sep 15; 21(18):5855-69. Tsigelny IF, Kouznetsova VL, Biswas N, Mahata SK, O'Connor DT. PMID: 23916146.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19; 33(25):10221-34. Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny IF, Sassone-Corsi P, Ptácek LJ, Akassoglou K. PMID: 23785138.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    36. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano. 2013 May 28; 7(5):4289-98. Chao Y, Karmali PP, Mukthavaram R, Kesari S, Kouznetsova VL, Tsigelny IF, Simberg D. PMID: 23614696.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    37. A hierarchical coherent-gene-group model for brain development. Genes Brain Behav. 2013 Mar; 12(2):147-65. Tsigelny IF, Kouznetsova VL, Baitaluk M, Changeux JP. PMID: 23173912.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. An all-atom model of the structure of human copper transporter 1. Cell Biochem Biophys. 2012 Jul; 63(3):223-34. Tsigelny IF, Sharikov Y, Greenberg JP, Miller MA, Kouznetsova VL, Larson CA, Howell SB. PMID: 22569840.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9. Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. PMID: 22515422.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    40. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    41. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. PMID: 21499753.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    42. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem. 2011 Jun 01; 19(11):3320-40. Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam SK. PMID: 21571536.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    43. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011 Jun 03; 10(6):2842-51. Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK. PMID: 21476605.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    44. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. PMID: 21045796.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    45. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. PMID: 20978615.
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    46. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. PMID: 20154271.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    47. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. . 2010 Mar; 298(3):C496-509. Burg ED, Platoshyn O, Tsigelny IF, Lozano-Ruiz B, Rana BK, Yuan JX. PMID: 20018952.
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    48. Interaction of organic cations with organic anion transporters. J Biol Chem. 2009 Nov 06; 284(45):31422-30. Ahn SY, Eraly SA, Tsigelny I, Nigam SK. PMID: 19737926.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    49. Role of synucleins in Alzheimer's disease. Neurotox Res. 2009 Oct; 16(3):306-17. Crews L, Tsigelny I, Hashimoto M, Masliah E. PMID: 19551456.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    50. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008 Dec 09; 1(49):ra16. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam SK. PMID: 19066399.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    51. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol. 2008 Oct; 6(5):885-904. Tsigelny IF, Greenberg J, Kouznetsova V, Nigam SK. PMID: 18942157.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    52. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    53. Thermal denaturation of wild type and mutant recombinant acetylcholinesterase from amphioxus: effects of the temperature of in vitro expression and of reversible inhibitors. Invert Neurosci. 2008 Sep; 8(3):147-55. Perrin B, Rowland M, Wolfe M, Tsigelny I, Pezzementi L. PMID: 18677525.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    54. Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies. Nanomedicine. 2008 Dec; 4(4):350-7. Tsigelny IF, Sharikov Y, Miller MA, Masliah E. PMID: 18640077.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    55. Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: a reconsideration of the implications for insecticide design. Chem Biol Interact. 2008 Sep 25; 175(1-3):73-5. Rowland M, Tsigelny I, Wolfe M, Pezzementi L. PMID: 18384763.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    56. Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide. FEBS J. 2008 Mar; 275(6):1309-22. Frederick A, Tsigelny I, Cohenour F, Spiker C, Krejci E, Chatonnet A, Bourgoin S, Richards G, Allen T, Whitlock MH, Pezzementi L. PMID: 18279391.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    57. MAPAS: a tool for predicting membrane-contacting protein surfaces. Nat Methods. 2008 Feb; 5(2):119. Sharikov Y, Walker RC, Greenberg J, Kouznetsova V, Nigam SK, Miller MA, Masliah E, Tsigelny IF. PMID: 18235431.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    58. Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). Biol Cell. 2007 Aug; 99(8):433-44. Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH. PMID: 17388782.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    59. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol. 2007 Jun 18; 177(6):1119-32. Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. PMID: 17576803.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    60. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure. 2007 Jun; 15(6):693-705. Comoletti D, Grishaev A, Whitten AE, Tsigelny I, Taylor P, Trewhella J. PMID: 17562316.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    61. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77. Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. PMID: 17381514.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    62. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem. 2007; 14(27):2925-36. Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. PMID: 18045138.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    63. The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state. J Bacteriol. 2006 Jul; 188(13):4970-7. Varughese KI, Tsigelny I, Zhao H. PMID: 16788205.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    64. Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem. 2006 Aug 25; 281(34):24678-86. Talley TT, Olivera BM, Han KH, Christensen SB, Dowell C, Tsigelny I, Ho KY, Taylor P, McIntosh JM. PMID: 16803900.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    65. Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: the roles of two cysteines in the catalytic gorge of the enzyme. Invert Neurosci. 2006 Jun; 6(2):47-55. Pezzementi L, Rowland M, Wolfe M, Tsigelny I. PMID: 16586114.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    66. A tryptophan in the bottleneck of the catalytic gorge of an invertebrate acetylcholinesterase confers relative resistance to carbamate and organophosphate inhibitors. Cell Biochem Biophys. 2006; 46(3):253-64. Patel R, Sanders R, Brown L, Baker S, Tsigelny I, Pezzementi L. PMID: 17272851.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    67. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem. 2005 Jun 10; 280(23):22365-74. Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC. PMID: 15797875.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    68. Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis. Cell Biochem Biophys. 2005; 42(1):41-53. Tsigelny I, Hotchko M, Yuan JX, Keller SH. PMID: 15673927.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    69. Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma. J Biomed Biotechnol. 2005; 2005(4):353-63. Tsigelny I, Burton DW, Sharikov Y, Hastings RH, Deftos LJ. PMID: 16489268.
      View in: PubMed   Mentions: 1     Fields:    
    70. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci. 2004 May 19; 24(20):4889-93. Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. PMID: 15152050.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    71. Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. Regul Pept. 2004 Apr 15; 118(1-2):75-87. Preece NE, Nguyen M, Mahata M, Mahata SK, Mahapatra NR, Tsigelny I, O'Connor DT. PMID: 14759560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    72. SNP analysis combined with protein structure prediction defines structure-functional relationships in cancer related cytochrome P450 estrogen metabolism. Curr Med Chem. 2004 Mar; 11(5):525-38. Tsigelny IF, Kotlovyi V, Wasserman L. PMID: 15032601.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry. 2004 Feb 17; 43(6):1496-506. Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor P. PMID: 14769026.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    74. Complex dynamics of chaperone-protein interactions under cellular stress. Cell Biochem Biophys. 2004; 40(3):263-76. Tsigelny IF, Nigam SK. PMID: 15211027.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    75. Amino acids defining the acyl pocket of an invertebrate cholinesterase. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec; 136(4):813-32. Pezzementi L, Johnson K, Tsigelny I, Cotney J, Manning E, Barker A, Merritt S. PMID: 14662305.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    76. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. PMID: 14583592.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    77. Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information. Proteins. 2003 Jul 01; 52(1):33-40. Law DS, Ten Eyck LF, Katzenelson O, Tsigelny I, Roberts VA, Pique ME, Mitchell JC. PMID: 12784365.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    78. Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein. J Biol Chem. 2002 Nov 01; 277(44):41299-302. Hansen SB, Radic' Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, Taylor P. PMID: 12235129.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    79. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site. Biochemistry. 2002 Jun 25; 41(25):7895-906. Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. PMID: 12069578.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    80. Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information. Protein Eng. 2002 May; 15(5):347-52. Tsigelny I, Sharikov Y, Ten Eyck LF. PMID: 12034853.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    81. Electrostatic environment surrounding the activation loop phosphotyrosine in the oncoprotein v-Fps. Biochemistry. 2001 Aug 28; 40(34):10078-86. Leon BC, Tsigelny I, Adams JA. PMID: 11513586.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    82. Protein docking using continuum electrostatics and geometric fit. Protein Eng. 2001 Feb; 14(2):105-13. Mandell JG, Roberts VA, Pique ME, Kotlovyi V, Mitchell JC, Nelson E, Tsigelny I, Ten Eyck LF. PMID: 11297668.
      View in: PubMed   Mentions: 94     Fields:    Translation:Cells
    83. Catalytic assessment of the glycine-rich loop of the v-Fps oncoprotein using site-directed mutagenesis. Biochemistry. 2000 Oct 31; 39(43):13276-84. Hirai TJ, Tsigelny I, Adams JA. PMID: 11052681.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    84. Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure. Pflugers Arch. 2000; 440(5 Suppl):R115-7. Taylor P, Malanz S, Molles BE, Osaka H, Tsigelny I. PMID: 11005635.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    85. Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations. Protein Sci. 2000 Jan; 9(1):180-5. Tsigelny I, Shindyalov IN, Bourne PE, Südhof TC, Taylor P. PMID: 10739260.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    86. Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure. Pflugers Arch. 2000 Jan; 440(Suppl 1):R115-R117. Taylor P, Malany S, Molles BE, Osaka H, Tsigelny I. PMID: 28008504.
      View in: PubMed   Mentions: 1     Fields:    
    87. 600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers. 1999 Oct 15; 50(5):513-24. Tsigelny I, Greenberg JP, Cox S, Nichols WL, Taylor SS, Ten Eyck LF. PMID: 10479734.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    88. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity. Chem Biol Interact. 1999 May 14; 119-120:3-15. Taylor P, Wong L, Radic Z, Tsigelny I, Brüggemann R, Hosea NA, Berman HA. PMID: 10421434.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    89. Delineation of selective cyclic GMP-dependent protein kinase Ialpha substrate and inhibitor peptides based on combinatorial peptide libraries on paper. Pharmacol Ther. 1999 May-Jun; 82(2-3):373-87. Dostmann WR, Nickl C, Thiel S, Tsigelny I, Frank R, Tegge WJ. PMID: 10454213.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    90. Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity. Regul Pept. 1998 Oct 16; 77(1-3):43-53. Tsigelny I, Mahata SK, Taupenot L, Preece NE, Mahata M, Khan I, Parmer RJ, O'Connor DT. PMID: 9809795.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    91. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry. 1998 May 26; 37(21):7708-15. Grant BD, Hemmer W, Tsigelny I, Adams JA, Taylor SS. PMID: 9601030.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    92. Identification of pairwise interactions in the alpha-neurotoxin-nicotinic acetylcholine receptor complex through double mutant cycles. J Biol Chem. 1998 May 01; 273(18):10958-64. Ackermann EJ, Ang ET, Kanter JR, Tsigelny I, Taylor P. PMID: 9556574.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    93. Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure. J Physiol Paris. 1998 Apr; 92(2):79-83. Taylor P, Osaka H, Molles BE, Sugiyama N, Marchot P, Ackermann EJ, Malany S, McArdle JJ, Sine SM, Tsigelny I. PMID: 9782448.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    94. Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. J Biol Chem. 1997 Jul 04; 272(27):16946-54. Hemmer W, McGlone M, Tsigelny I, Taylor SS. PMID: 9202006.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    95. A model of the nicotinic receptor extracellular domain based on sequence identity and residue location. Biophys J. 1997 Jul; 73(1):52-66. Tsigelny I, Sugiyama N, Sine SM, Taylor P. PMID: 9199771.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    96. Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics. J Pept Res. 1997 Mar; 49(3):210-20. Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS. PMID: 9151254.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    97. Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy. J Biol Chem. 1997 Jan 17; 272(3):1507-13. Lew J, Coruh N, Tsigelny I, Garrod S, Taylor SS. PMID: 8999821.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    98. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4):249-60. Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. PMID: 9676269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    99. Structures important in NAD(P)(H) specificity for mammalian retinol and 11-Cis-retinol dehydrogenases. Biochem Biophys Res Commun. 1996 Sep 04; 226(1):118-27. Tsigelny I, Baker ME. PMID: 8806601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    100. Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition. Biopolymers. 1996 Sep; 39(3):353-65. Tsigelny I, Grant BD, Taylor SS, Ten Eyck LF. PMID: 8756515.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    101. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry. 1996 Aug 20; 35(33):10995-1004. Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. PMID: 8718893.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    102. Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit. Protein Sci. 1996 Jul; 5(7):1316-24. Grant BD, Tsigelny I, Adams JA, Taylor SS. PMID: 8819164.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    103. Structures stabilizing the dimer interface on human 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase and their homologs. Biochem Biophys Res Commun. 1995 Dec 26; 217(3):859-68. Tsigelny I, Baker ME. PMID: 8554609.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    104. Structures important in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol. 1995 Dec; 55(5-6):589-600. Tsigelny I, Baker ME. PMID: 8547186.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    105. Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. Biochem J. 1995 Jun 01; 308 ( Pt 2):419-23. Chenevert SW, Fossett NG, Chang SH, Tsigelny I, Baker ME, Lee WR. PMID: 7772022.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    106. Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase. Protein Sci. 1995 Apr; 4(4):703-15. van den Born HK, Radic Z, Marchot P, Taylor P, Tsigelny I. PMID: 7613468.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    107. Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. J Biol Chem. 1995 Mar 17; 270(11):6370-80. Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P. PMID: 7890775.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    108. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 1994 Dec 15; 8(24):2996-3007. Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. PMID: 8001819.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    109. Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. FEBS Lett. 1994 Dec 12; 356(1):81-5. Chen Z, Tsigelny I, Lee WR, Baker ME, Chang SH. PMID: 7988726.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    110. Protein kinases share a common structural motif outside the conserved catalytic domain. Cell Mol Biol (Noisy-le-grand). 1994 Jul; 40(5):587-96. Véron M, Radzio-Andzelm E, Tsigelny I, Taylor S. PMID: 7981616.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    111. A conserved helix motif complements the protein kinase core. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10618-22. Veron M, Radzio-Andzelm E, Tsigelny I, Ten Eyck LF, Taylor SS. PMID: 7504272.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
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