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    Igor Tsigelny

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    DepartmentNeurosciences
    Address9500 Gilman Drive #0505
    CA La Jolla 92093
    Phone858-822-0953
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Choi MY, Tsigelny I, Boichard A, Skjevik ÅA, Shabaik A, Kurzrock R. BRAF Mutation as a Novel Driver of Eosinophilic Cystitis. Cancer Biol Ther. 2017 Aug 22; 0. PMID: 28829677.
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      2. Boichard A, Tsigelny I, Kurzrock R. High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations. Oncoimmunology. 2017; 6(3):e1284719. PMID: 28405512.
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      3. Wrasidlo W, Tsigelny I, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 Dec; 139(Pt 12):3217-3236. PMID: 27679481.
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      4. Tsigelny I, Kouznetsova VL, Lian N, Kesari S. Molecular mechanisms of OLIG2 transcription factor in brain cancer. Oncotarget. 2016 Aug 16; 7(33):53074-53101. PMID: 27447975.
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      5. Tsigelny I, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2015 Oct 30. PMID: 26517684.
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      6. Yamamoto T, Tsigelny I, Götz AW, Howell SB. Cisplatin inhibits MEK1/2. Oncotarget. 2015 Sep 15; 6(27):23510-22. PMID: 26155939.
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      7. Tsai CY, Liebig JK, Tsigelny I, Howell SB. The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). Metallomics. 2015 Nov 4; 7(11):1477-87. PMID: 26205368.
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      8. Tsigelny I, Wheler JJ, Greenberg JP, Kouznetsova VL, Stewart DJ, Bazhenova L, Kurzrock R. Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer. Oncotarget. 2015 Mar 20; 6(8):6029-39. PMID: 25760241.
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      9. Tsigelny I, Kouznetsova VL, Jiang P, Pingle SC, Kesari S. Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma. Mol Biosyst. 2015 Mar 17; 11(4):1012-28. PMID: 25648506.
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      10. Tsigelny I, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. Molecular Determinants of a-Synuclein Mutants' Oligomerization and Membrane Interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. PMID: 25561023.
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      11. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny I, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Sep 22. PMID: 25288184.
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      12. Tsigelny I, Kouznetsova VL, Pingle SC, Kesari S. bHLH Transcription Factors Inhibitors for Cancer Therapy: General Features for In Silico Drug Design. Curr Med Chem. 2014; 21(28):3227-43. PMID: 24735358.
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      13. Tsigelny I, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. Structural Diversity of Alzheimer's Disease Amyloid-ß Dimers and Their Role in Oligomerization and Fibril Formation. J Alzheimers Dis. 2014 Jan 1; 39(3):583-600. PMID: 24240640.
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      14. Tsigelny I, Kouznetsova VL, Biswas N, Mahata SK, O'Connor DT. Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Bioorg Med Chem. 2013 Sep 15; 21(18):5855-69. PMID: 23916146.
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      15. Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny I, Sassone-Corsi P, Ptácek LJ, Akassoglou K. p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19; 33(25):10221-34. PMID: 23785138.
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      16. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny I, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. PMID: 23656327.
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      17. Chao Y, Karmali PP, Mukthavaram R, Kesari S, Kouznetsova VL, Tsigelny I, Simberg D. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano. 2013 May 28; 7(5):4289-98. PMID: 23614696.
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      18. Tsigelny I, Kouznetsova VL, Baitaluk M, Changeux JP. A hierarchical coherent-gene-group model for brain development. Genes Brain Behav. 2013 Mar; 12(2):147-65. PMID: 23173912.
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      19. Tsigelny I, Sharikov Y, Greenberg JP, Miller MA, Kouznetsova VL, Larson CA, Howell SB. An all-atom model of the structure of human copper transporter 1. Cell Biochem Biophys. 2012 Jul; 63(3):223-34. PMID: 22569840.
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      20. Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. Recognition of Dextran-Superparamagnetic Iron Oxide Nanoparticle Conjugates (Feridex) via Macrophage Scavenger Receptor Charged Domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9. PMID: 22515422.
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      21. Tsigelny I, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. PMID: 22251432.
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      22. Tsigelny I, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. PMID: 21499753.
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      23. Kouznetsova VL, Tsigelny I, Nagle MA, Nigam SK. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem. 2011 Jun 1; 19(11):3320-40. PMID: 21571536.
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      24. Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny I, Nigam SK. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011 Jun 3; 10(6):2842-51. PMID: 21476605.
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      25. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 Dec; 6(12):702-6. PMID: 21045796.
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      26. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010; 6:742-7. PMID: 20978615.
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      27. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4299-304. PMID: 20154271.
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      28. Burg ED, Platoshyn O, Tsigelny I, Lozano-Ruiz B, Rana BK, Yuan JX. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C496-509. PMID: 20018952.
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      29. Ahn SY, Eraly SA, Tsigelny I, Nigam SK. Interaction of organic cations with organic anion transporters. J Biol Chem. 2009 Nov 6; 284(45):31422-30. PMID: 19737926.
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      30. Crews L, Tsigelny I, Hashimoto M, Masliah E. Role of synucleins in Alzheimer's disease. Neurotox Res. 2009 Oct; 16(3):306-17. PMID: 19551456.
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      31. Tsigelny I, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam SK. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008; 1(49):ra16. PMID: 19066399.
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      32. Tsigelny I, Greenberg J, Kouznetsova V, Nigam SK. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol. 2008 Oct; 6(5):885-904. PMID: 18942157.
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      33. Tsigelny I, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008; 3(9):e3135. PMID: 18769546.
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      34. Perrin B, Rowland M, Wolfe M, Tsigelny I, Pezzementi L. Thermal denaturation of wild type and mutant recombinant acetylcholinesterase from amphioxus: effects of the temperature of in vitro expression and of reversible inhibitors. Invert Neurosci. 2008 Sep; 8(3):147-55. PMID: 18677525.
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      35. Tsigelny I, Sharikov Y, Miller MA, Masliah E. Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies. Nanomedicine. 2008 Dec; 4(4):350-7. PMID: 18640077.
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      36. Rowland M, Tsigelny I, Wolfe M, Pezzementi L. Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: a reconsideration of the implications for insecticide design. Chem Biol Interact. 2008 Sep 25; 175(1-3):73-5. PMID: 18384763.
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      37. Frederick A, Tsigelny I, Cohenour F, Spiker C, Krejci E, Chatonnet A, Bourgoin S, Richards G, Allen T, Whitlock MH, Pezzementi L. Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide. FEBS J. 2008 Mar; 275(6):1309-22. PMID: 18279391.
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      38. Sharikov Y, Walker RC, Greenberg J, Kouznetsova V, Nigam SK, Miller MA, Masliah E, Tsigelny I. MAPAS: a tool for predicting membrane-contacting protein surfaces. Nat Methods. 2008 Feb; 5(2):119. PMID: 18235431.
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      39. Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH. Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). Biol Cell. 2007 Aug; 99(8):433-44. PMID: 17388782.
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      40. Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol. 2007 Jun 18; 177(6):1119-32. PMID: 17576803.
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      41. Comoletti D, Grishaev A, Whitten AE, Tsigelny I, Taylor P, Trewhella J. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure. 2007 Jun; 15(6):693-705. PMID: 17562316.
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      42. Tsigelny I, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77. PMID: 17381514.
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      43. Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem. 2007; 14(27):2925-36. PMID: 18045138.
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      44. Varughese KI, Tsigelny I, Zhao H. The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state. J Bacteriol. 2006 Jul; 188(13):4970-7. PMID: 16788205.
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      45. Talley TT, Olivera BM, Han KH, Christensen SB, Dowell C, Tsigelny I, Ho KY, Taylor P, McIntosh JM. Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem. 2006 Aug 25; 281(34):24678-86. PMID: 16803900.
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      46. Pezzementi L, Rowland M, Wolfe M, Tsigelny I. Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: the roles of two cysteines in the catalytic gorge of the enzyme. Invert Neurosci. 2006 Jun; 6(2):47-55. PMID: 16586114.
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      47. Patel R, Sanders R, Brown L, Baker S, Tsigelny I, Pezzementi L. A tryptophan in the bottleneck of the catalytic gorge of an invertebrate acetylcholinesterase confers relative resistance to carbamate and organophosphate inhibitors. Cell Biochem Biophys. 2006; 46(3):253-64. PMID: 17272851.
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      48. Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem. 2005 Jun 10; 280(23):22365-74. PMID: 15797875.
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      49. Tsigelny I, Hotchko M, Yuan JX, Keller SH. Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis. Cell Biochem Biophys. 2005; 42(1):41-53. PMID: 15673927.
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      50. Tsigelny I, Burton DW, Sharikov Y, Hastings RH, Deftos LJ. Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma. J Biomed Biotechnol. 2005; 2005(4):353-63. PMID: 16489268.
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      51. Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci. 2004 May 19; 24(20):4889-93. PMID: 15152050.
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      52. Preece NE, Nguyen M, Mahata M, Mahata SK, Mahapatra NR, Tsigelny I, O'Connor DT. Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. Regul Pept. 2004 Apr 15; 118(1-2):75-87. PMID: 14759560.
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      53. Tsigelny I, Kotlovyi V, Wasserman L. SNP analysis combined with protein structure prediction defines structure-functional relationships in cancer related cytochrome P450 estrogen metabolism. Curr Med Chem. 2004 Mar; 11(5):525-38. PMID: 15032601.
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      54. Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor P. Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry. 2004 Feb 17; 43(6):1496-506. PMID: 14769026.
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      55. Tsigelny I, Nigam SK. Complex dynamics of chaperone-protein interactions under cellular stress. Cell Biochem Biophys. 2004; 40(3):263-76. PMID: 15211027.
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      56. Pezzementi L, Johnson K, Tsigelny I, Cotney J, Manning E, Barker A, Merritt S. Amino acids defining the acyl pocket of an invertebrate cholinesterase. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec; 136(4):813-32. PMID: 14662305.
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      57. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. PMID: 14583592.
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      58. Law DS, Ten Eyck LF, Katzenelson O, Tsigelny I, Roberts VA, Pique ME, Mitchell JC. Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information. Proteins. 2003 Jul 1; 52(1):33-40. PMID: 12784365.
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      59. Hansen SB, Radic' Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, Taylor P. Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein. J Biol Chem. 2002 Nov 1; 277(44):41299-302. PMID: 12235129.
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      60. Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site. Biochemistry. 2002 Jun 25; 41(25):7895-906. PMID: 12069578.
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      61. Tsigelny I, Sharikov Y, Ten Eyck LF. Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information. Protein Eng. 2002 May; 15(5):347-52. PMID: 12034853.
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      62. Leon BC, Tsigelny I, Adams JA. Electrostatic environment surrounding the activation loop phosphotyrosine in the oncoprotein v-Fps. Biochemistry. 2001 Aug 28; 40(34):10078-86. PMID: 11513586.
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      63. Mandell JG, Roberts VA, Pique ME, Kotlovyi V, Mitchell JC, Nelson E, Tsigelny I, Ten Eyck LF. Protein docking using continuum electrostatics and geometric fit. Protein Eng. 2001 Feb; 14(2):105-13. PMID: 11297668.
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      64. Hirai TJ, Tsigelny I, Adams JA. Catalytic assessment of the glycine-rich loop of the v-Fps oncoprotein using site-directed mutagenesis. Biochemistry. 2000 Oct 31; 39(43):13276-84. PMID: 11052681.
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      65. Taylor P, Malanz S, Molles BE, Osaka H, Tsigelny I. Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure. Pflugers Arch. 2000; 440(5 Suppl):R115-7. PMID: 11005635.
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      66. Tsigelny I, Shindyalov IN, Bourne PE, Südhof TC, Taylor P. Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations. Protein Sci. 2000 Jan; 9(1):180-5. PMID: 10739260.
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      67. Taylor P, Malany S, Molles BE, Osaka H, Tsigelny I. Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure. Pflugers Arch. 2000 Jan; 440(Suppl 1):R115-R117. PMID: 28008504.
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      68. Tsigelny I, Greenberg JP, Cox S, Nichols WL, Taylor SS, Ten Eyck LF. 600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers. 1999 Oct 15; 50(5):513-24. PMID: 10479734.
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      69. Taylor P, Wong L, Radic Z, Tsigelny I, Brüggemann R, Hosea NA, Berman HA. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity. Chem Biol Interact. 1999 May 14; 119-120:3-15. PMID: 10421434.
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      70. Dostmann WR, Nickl C, Thiel S, Tsigelny I, Frank R, Tegge WJ. Delineation of selective cyclic GMP-dependent protein kinase Ialpha substrate and inhibitor peptides based on combinatorial peptide libraries on paper. Pharmacol Ther. 1999 May-Jun; 82(2-3):373-87. PMID: 10454213.
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      71. Tsigelny I, Mahata SK, Taupenot L, Preece NE, Mahata M, Khan I, Parmer RJ, O'Connor DT. Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity. Regul Pept. 1998 Oct 16; 77(1-3):43-53. PMID: 9809795.
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      72. Grant BD, Hemmer W, Tsigelny I, Adams JA, Taylor SS. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry. 1998 May 26; 37(21):7708-15. PMID: 9601030.
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      73. Ackermann EJ, Ang ET, Kanter JR, Tsigelny I, Taylor P. Identification of pairwise interactions in the alpha-neurotoxin-nicotinic acetylcholine receptor complex through double mutant cycles. J Biol Chem. 1998 May 1; 273(18):10958-64. PMID: 9556574.
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      74. Taylor P, Osaka H, Molles BE, Sugiyama N, Marchot P, Ackermann EJ, Malany S, McArdle JJ, Sine SM, Tsigelny I. Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure. J Physiol Paris. 1998 Apr; 92(2):79-83. PMID: 9782448.
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      75. Hemmer W, McGlone M, Tsigelny I, Taylor SS. Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. J Biol Chem. 1997 Jul 4; 272(27):16946-54. PMID: 9202006.
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      76. Tsigelny I, Sugiyama N, Sine SM, Taylor P. A model of the nicotinic receptor extracellular domain based on sequence identity and residue location. Biophys J. 1997 Jul; 73(1):52-66. PMID: 9199771.
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      77. Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS. Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics. J Pept Res. 1997 Mar; 49(3):210-20. PMID: 9151254.
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      78. Lew J, Coruh N, Tsigelny I, Garrod S, Taylor SS. Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy. J Biol Chem. 1997 Jan 17; 272(3):1507-13. PMID: 8999821.
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      79. Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4):249-60. PMID: 9676269.
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      80. Tsigelny I, Baker ME. Structures important in NAD(P)(H) specificity for mammalian retinol and 11-Cis-retinol dehydrogenases. Biochem Biophys Res Commun. 1996 Sep 4; 226(1):118-27. PMID: 8806601.
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      81. Tsigelny I, Grant BD, Taylor SS, Ten Eyck LF. Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition. Biopolymers. 1996 Sep; 39(3):353-65. PMID: 8756515.
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      82. Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry. 1996 Aug 20; 35(33):10995-1004. PMID: 8718893.
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      83. Grant BD, Tsigelny I, Adams JA, Taylor SS. Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit. Protein Sci. 1996 Jul; 5(7):1316-24. PMID: 8819164.
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      84. Tsigelny I, Baker ME. Structures stabilizing the dimer interface on human 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase and their homologs. Biochem Biophys Res Commun. 1995 Dec 26; 217(3):859-68. PMID: 8554609.
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      85. Tsigelny I, Baker ME. Structures important in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol. 1995 Dec; 55(5-6):589-600. PMID: 8547186.
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      86. Chenevert SW, Fossett NG, Chang SH, Tsigelny I, Baker ME, Lee WR. Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. Biochem J. 1995 Jun 1; 308 ( Pt 2):419-23. PMID: 7772022.
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      87. van den Born HK, Radic Z, Marchot P, Taylor P, Tsigelny I. Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase. Protein Sci. 1995 Apr; 4(4):703-15. PMID: 7613468.
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      88. Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P. Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. J Biol Chem. 1995 Mar 17; 270(11):6370-80. PMID: 7890775.
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      89. Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 1994 Dec 15; 8(24):2996-3007. PMID: 8001819.
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      90. Chen Z, Tsigelny I, Lee WR, Baker ME, Chang SH. Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. FEBS Lett. 1994 Dec 12; 356(1):81-5. PMID: 7988726.
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