Philip Gordts

Title(s)Assistant Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-7224-4328 Additional info
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    Collapse Biography 
    Collapse Education and Training
    KU Leuven, BelgiumPhDMedicine
    KU Leuven, BelgiumMSBiomedical Science
    Collapse Awards and Honors
    European Lipoprotein Club2007Young Investigator Award
    International Atherosclerosis Society2006Young Investigator Award
    European Union2011Marie Curie International outgoing fellowship
    University of California, San Diego2014UCSD Chancellor’s Award for Outstanding Postdoctoral Scholar
    American Heart Association2015Beginning Grant In-Aid Award
    Journal of Lipid Research 2016Junior Investigator Award
    UC San Diego2020National Center of Leadership in Academic Medicine Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
    NIH R01DK126848Feb 1, 2021 - Nov 30, 2025
    Role: Principal Investigator
    Exploring The Impact of Human Milk Oligosaccharides in Atherosclerosis
    NIH R21HD089067Aug 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    LEAN (Leducq Epigenetics of Atherosclerosis Network)
    Foundation Leducq 16CVD01Jan 1, 2017 - Dec 31, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis. J Clin Invest. 2024 Mar 01; 134(5). Nakamura Y, Kulkarni NN, Takahashi T, Alimohamadi H, Dokoshi T, Liu E, Shia M, Numata T, Luo EW, Gombart AF, Yang X, Secrest P, Gordts PL, Tsimikas S, Wong GC, Gallo RL. PMID: 38194294; PMCID: PMC10904043.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter. bioRxiv. 2023 Nov 21. Gioia MD, Poli V, Tan PJ, Spreafico R, Chu A, Cuenca AG, Gordts PL, Pandolfi L, Meloni F, Witztum JL, Chou J, Springstead JR, Zanoni I. PMID: 38045410; PMCID: PMC10690175.
      View in: PubMed   Mentions:
    3. Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ Health Perspect. 2023 09; 131(9):97001. Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S. PMID: 37668303; PMCID: PMC10478510.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins. Cell Genom. 2023 Jul 12; 3(7):100339. DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, Du X, De Arruda Saldanha C, Gylys J, Merli E, Abagyan R, Najmi L, Mohan V, Alnylam Human Genetics, AMP-T2D Consortium, Flannick J, Peloso GM, Gordts PLSM, Heinz S, Deaton AM, Khera AV, Olefsky J, Radha V, Majithia AR. PMID: 37492105; PMCID: PMC10363808.
      View in: PubMed   Mentions: 2  
    5. Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism. J Biol Chem. 2023 05; 299(5):104611. Trieger GW, Pessentheiner AR, Purcell SC, Green CR, DeForest N, Willert K, Majithia AR, Metallo CM, Godula K, Gordts PLSM. PMID: 36931394; PMCID: PMC10164900.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 12 01; 71(12):2513-2529. Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M, Sander M. PMID: 36162056; PMCID: PMC9750949.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering. JCI Insight. 2022 07 08; 7(13). Ramms B, Patel S, Sun X, Pessentheiner AR, Ducasa GM, Mullick AE, Lee RG, Crooke RM, Tsimikas S, Witztum JL, Gordts PL. PMID: 35653195; PMCID: PMC9310539.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation. J Biol Chem. 2022 08; 298(8):102159. Tillo M, Lamanna WC, Dwyer CA, Sandoval DR, Pessentheiner AR, Al-Azzam N, Sarrazin S, Gonzales JC, Kan SH, Andreyev AY, Schultheis N, Thacker BE, Glass CA, Dickson PI, Wang RY, Selleck SB, Esko JD, Gordts PLSM. PMID: 35750212; PMCID: PMC9364035.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Biologically Derived Neoproteoglycans for Profiling Protein-Glycosaminoglycan Interactions. ACS Chem Biol. 2022 06 17; 17(6):1534-1542. Porell RN, Follmar JL, Purcell SC, Timm B, Laubach LK, Kozirovskiy D, Thacker BE, Glass CA, Gordts PLSM, Godula K. PMID: 35574759.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2022 May; 18(5):575. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. PMID: 35354934.
      View in: PubMed   Mentions:    Fields:    
    11. Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated With Human-Like Neu5Gc Loss-Brief Report. Arterioscler Thromb Vasc Biol. 2021 11; 41(11):2730-2739. Kawanishi K, Coker JK, Grunddal KV, Dhar C, Hsiao J, Zengler K, Varki N, Varki A, Gordts PLSM. PMID: 34587757; PMCID: PMC8551057.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2021 06; 17(6):684-692. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. PMID: 33846619; PMCID: PMC8159865.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection. bioRxiv. 2021 Mar 26. Sandoval DR, Clausen TM, Nora C, Cribbs AP, Denardo A, Clark AE, Garretson AF, Coker JKC, Narayanan A, Majowicz SA, Philpott M, Johansson C, Dunford JE, Spliid CB, Golden GJ, Payne NC, Tye MA, Nowell CJ, Griffis ER, Piermatteo A, Grunddal KV, Alle T, Magida JA, Hauser BM, Feldman J, Caradonna TM, Pu Y, Yin X, McVicar RN, Kwong EM, Weiss RJ, Downes M, Tsimikas S, Smidt AG, Ballatore C, Zengler K, Evans RM, Chanda SK, Croker BA, Leibel SL, Jose J, Mazitschek R, Oppermann U, Esko JD, Carlin AF, Gordts PLSM. PMID: 33791697; PMCID: PMC8010724.
      View in: PubMed   Mentions: 2  
    14. microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production. JCI Insight. 2020 12 03; 5(23). Dong J, He M, Li J, Pessentheiner A, Wang C, Zhang J, Sun Y, Wang WT, Zhang Y, Liu J, Wang SC, Huang PH, Gordts PL, Yuan ZY, Tsimikas S, Shyy JY. PMID: 33119548; PMCID: PMC7714402.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    15. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020 11 12; 183(4):1043-1057.e15. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32970989; PMCID: PMC7489987.
      View in: PubMed   Mentions: 579     Fields:    Translation:HumansCellsPHPublic Health
    16. Corrigendum to: Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants. Glycobiology. 2020 08 20; 30(9):760. Anower-E-Khuda F, Singh G, Deng Y, Gordts PLSM, Esko JD. PMID: 32091093; PMCID: PMC7443331.
      View in: PubMed   Mentions:    Fields:    
    17. Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2020 Jul 24; 295(30):10508. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. PMID: 32709762; PMCID: PMC7383380.
      View in: PubMed   Mentions:    Fields:    
    18. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. bioRxiv. 2020 Jul 14. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32699853; PMCID: PMC7373134.
      View in: PubMed   Mentions: 1  
    19. Statin therapy increases lipoprotein(a) levels. Eur Heart J. 2020 06 21; 41(24):2275-2284. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31111151.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    20. Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation. Front Immunol. 2020; 11:769. Pessentheiner AR, Ducasa GM, Gordts PLSM. PMID: 32508807; PMCID: PMC7248225.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    21. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9311-9317. Weiss RJ, Spahn PN, Toledo AG, Chiang AWT, Kellman BP, Li J, Benner C, Glass CK, Gordts PLSM, Lewis NE, Esko JD. PMID: 32277030; PMCID: PMC7196839.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2020 Mar 13; 295(11):3747. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. PMID: 32169857; PMCID: PMC7076228.
      View in: PubMed   Mentions:    Fields:    
    23. Corrigendum to "The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis" [Matrix Biol. 71-72 (2018) 262-282]. Matrix Biol. 2020 06; 88:89. Gordts PLSM, Esko JD. PMID: 32144003.
      View in: PubMed   Mentions: 1     Fields:    
    24. Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via CMAH loss. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):1847-1848. Kawanishi K, Dhar C, Varki A, Gordts PLSM. PMID: 31964837; PMCID: PMC6994995.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    25. Statins and increases in Lp(a): an inconvenient truth that needs attention. Eur Heart J. 2020 01 01; 41(1):192-193. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31893480.
      View in: PubMed   Mentions: 11     Fields:    
    26. ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors. Arterioscler Thromb Vasc Biol. 2019 10; 39(10):2145-2156. Kegulian NC, Ramms B, Horton S, Trenchevska O, Nedelkov D, Graham MJ, Lee RG, Esko JD, Yassine HN, Gordts PLSM. PMID: 31390883; PMCID: PMC6761044.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    27. Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms. Proc Natl Acad Sci U S A. 2019 08 06; 116(32):16036-16045. Kawanishi K, Dhar C, Do R, Varki N, Gordts PLSM, Varki A. PMID: 31332008; PMCID: PMC6690033.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    28. Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants. Glycobiology. 2019 07 19; 29(8):582-592. Anower-E-Khuda F, Singh G, Deng Y, Gordts PLSM, Esko JD. PMID: 31094413; PMCID: PMC6639542.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2019 09 06; 294(36):13292-13303. Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD. PMID: 31315930; PMCID: PMC6737225.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. J Lipid Res. 2019 08; 60(8):1379-1395. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. PMID: 31092690; PMCID: PMC6672034.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    31. Hyaluronan as a potential thermogenic rheostat. Nat Metab. 2019 05; 1(5):503-504. Gordts PLSM, Saltiel AR. PMID: 32694849.
      View in: PubMed   Mentions:    Fields:    
    32. LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2019 Oct; 56(10):7234-7245. Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM. PMID: 31004319; PMCID: PMC6728278.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1592-1603. Fischer AW, Albers K, Schlein C, Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J. PMID: 30904610; PMCID: PMC6624118.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Efficient Synthesis of Heparinoid Bioconjugates for Tailoring FGF2 Activity at the Stem Cell-Matrix Interface. Bioconjug Chem. 2019 03 20; 30(3):833-840. Trieger GW, Verespy S, Gordts PLSM, Godula K. PMID: 30668905; PMCID: PMC6860979.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants. Arterioscler Thromb Vasc Biol. 2018 10; 38(10):2327-2337. Tirronen A, Vuorio T, Kettunen S, Hokkanen K, Ramms B, Niskanen H, Laakso H, Kaikkonen MU, Jauhiainen M, Gordts PLSM, Ylä-Herttuala S. PMID: 30354205.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    36. The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins. Mol Metab. 2018 10; 16:88-99. Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J. PMID: 30100244; PMCID: PMC6158030.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Apolipoprotein C-III in triglyceride-rich lipoprotein metabolism. Curr Opin Lipidol. 2018 06; 29(3):171-179. Ramms B, Gordts PLSM. PMID: 29547399.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    38. The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biol. 2018 10; 71-72:262-282. Gordts PLSM, Esko JD. PMID: 29803939; PMCID: PMC6432921.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    39. AIBP protects against metabolic abnormalities and atherosclerosis. J Lipid Res. 2018 05; 59(5):854-863. Schneider DA, Choi SH, Agatisa-Boyle C, Zhu L, Kim J, Pattison J, Sears DD, Gordts PLSM, Fang L, Miller YI. PMID: 29559522; PMCID: PMC5928435.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    40. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. J Virol. 2018 03 15; 92(6). Clark AE, Sabalza M, Gordts PLSM, Spector DH. PMID: 29237845; PMCID: PMC5827393.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. ANGPTL3 targeting: The power of versatile lipid-lowering. Atherosclerosis. 2018 01; 268:185-187. Pessentheiner AR, Ramms B, Gordts PLSM. PMID: 29111225; PMCID: PMC10305733.
      View in: PubMed   Mentions:    Fields:    
    42. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. PMID: 28958576; PMCID: PMC5768556.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    43. Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List. Circ Res. 2017 03 31; 120(7):1050-1052. Yeang C, Gordts PL, Tsimikas S. PMID: 28360338; PMCID: PMC5470738.
      View in: PubMed   Mentions: 7     Fields:    
    44. Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431 239 Patients. Arterioscler Thromb Vasc Biol. 2017 Mar; 37(3):580-588. Moriarty PM, Varvel SA, Gordts PL, McConnell JP, Tsimikas S. PMID: 28062489; PMCID: PMC5323356.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    45. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 08 01; 126(8):2855-66. Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD. PMID: 27400128; PMCID: PMC4966320.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    46. Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. PLoS One. 2016; 11(3):e0150850. Khalid O, Vera MU, Gordts PL, Ellinwood NM, Schwartz PH, Dickson PI, Esko JD, Wang RY. PMID: 26986213; PMCID: PMC4795702.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    47. Dietary nitrate struggles in atherosclerosis. Atherosclerosis. 2016 Feb; 245:71-3. Ramms B, Gordts PL. PMID: 26708286.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. Weiss RJ, Gordts PL, Le D, Xu D, Esko JD, Tor Y. PMID: 28133533; PMCID: PMC5267326.
      View in: PubMed   Mentions: 12  
    49. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015 May; 47(5):528-34. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagiroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. PMID: 25848753; PMCID: PMC4414867.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    50. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10; 6:6356. Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. PMID: 25754609; PMCID: PMC4366535.
      View in: PubMed   Mentions: 190     Fields:    Translation:Animals
    51. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res. 2015 Mar; 56(3):665-673. Mooij HL, Bernelot Moens SJ, Gordts PSM, Stanford K, Foley E, van den Boogert MW, Witjes J, Hassing HC, Tanck M, van de Sande MJ, Levels JH, Kastelein JP, Stroes EG, Dallinga-Thie G, Esko J, Nieuwdorp M. PMID: 25568062; PMCID: PMC4340313.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCTClinical Trials
    52. Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β. Cytokine. 2015 Mar; 72(1):118-9. Gordts PL, Esko JD. PMID: 25573804.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    53. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. PMID: 25440058; PMCID: PMC4254584.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    54. Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2065-74. Foley EM, Gordts PLSM, Stanford KI, Gonzales JC, Lawrence R, Stoddard N, Esko JD. PMID: 23846497; PMCID: PMC3821931.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    55. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest. 2013 Jun; 123(6):2742-51. Gonzales JC, Gordts PL, Foley EM, Esko JD. PMID: 23676495; PMCID: PMC3668842.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 2012 Oct 19; 287(43):36283-90. Lamanna WC, Lawrence R, Sarrazin S, Lameda-Diaz C, Gordts PL, Moremen KW, Esko JD. PMID: 22952226; PMCID: PMC3476295.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    57. The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles. J Lipid Res. 2012 Oct; 53(10):2198-2204. Christoffersen C, Benn M, Christensen PM, Gordts PLSM, Roebroek AJM, Frikke-Schmidt R, Tybjaerg-Hansen A, Dahlbäck B, Nielsen LB. PMID: 22826357; PMCID: PMC3435552.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    58. Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. PLoS One. 2012; 7(6):e38330. Gordts PL, Bartelt A, Nilsson SK, Annaert W, Christoffersen C, Nielsen LB, Heeren J, Roebroek AJ. PMID: 22701627; PMCID: PMC3368875.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    59. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology. 2012 Jan; 55(1):277-86. Deng Y, Foley EM, Gonzales JC, Gordts PL, Li Y, Esko JD. PMID: 21898481; PMCID: PMC3245353.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    60. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011 Feb; 17(2):200-5. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J. PMID: 21258337.
      View in: PubMed   Mentions: 752     Fields:    Translation:HumansAnimals
    61. Knock-in approaches. Methods Mol Biol. 2011; 693:257-75. Roebroek AJ, Gordts PL, Reekmans S. PMID: 21080285.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    62. Generation of a series of knock-in alleles using RMCE in ES cells. Methods Mol Biol. 2011; 693:277-81. Roebroek AJ, Gordts PL, Reekmans S. PMID: 21080286.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    63. Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis. Circ Res. 2010 May 28; 106(10):1624-34. Christoffersen C, Pedersen TX, Gordts PL, Roebroek AJ, Dahlbäck B, Nielsen LB. PMID: 20360257.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    64. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cell Mol Life Sci. 2010 Jan; 67(1):135-45. Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU. PMID: 19856143.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    65. Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Sep; 29(9):1258-64. Gordts PL, Reekmans S, Lauwers A, Van Dongen A, Verbeek L, Roebroek AJ. PMID: 19667105.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
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