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Maurizio Zanetti

Title(s)Senate Emeritus, Medicine
SchoolHealth Sciences
Phone858-822-5412
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    (PQ3) Disruption of immune surveillance by aneuploidy and aberrant MHCII expression
    NIH/NCI R01CA220009Aug 17, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Phase 2 Study of Vascular-Targeted Prodrug (G-202) for the Treatment of Recurrent Glioblastoma
    FDA R01FD005077Apr 20, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Targeting Cancer miRNAs by Adoptive Transfer of Programmed B Lymphocytes
    NIH/NCI R21CA178674Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Genetically-Programmed APC Vaccines Against Viruses
    NIH/NIAID R56AI062894Sep 30, 2011 - Sep 29, 2014
    Role: Principal Investigator
    Genetically-Programmed APC Vaccines Against Viruses
    NIH/NIAID R01AI062894Feb 1, 2005 - Jan 31, 2009
    Role: Principal Investigator
    Conformationally-Constrained PA Anthrax Vaccine
    NIH/NIAID R21AI057889Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Novel APC Vaccine to Induce Anti-Tumor T cell Immunity
    NIH/NCI R01CA092119Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    Transgenic B-Cell Immunogenes
    NIH/NIAID R21AI049774May 1, 2001 - Apr 30, 2004
    Role: Principal Investigator
    TARGETED THERAPEUTIC VACCINATION IN PROSTATE CANCER
    NIH/NCI R01CA084062Jul 1, 2000 - Jun 30, 2005
    Role: Principal Investigator
    Strategies of Vaccination Against MUC.1 Antigen
    NIH/NCI R01CA077427Jul 23, 1999 - Nov 30, 2009
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    ANTIGENIZED ANTIBODY AND GENE IN MALARIA VACCINE
    NIH/NIAID U01AI036467Sep 15, 1994 - Aug 31, 1997
    Role: Principal Investigator
    MODULATION OF PERIPHERIAL T CELLS ACTIVITY
    NIH/NIAID P01AI033204Sep 1, 1992 - Apr 30, 1996
    Role: Principal Investigator
    ENGINEERED CD4-LIKE ANTIBODIES IN NEONATAL HIV INFECTION
    NIH/NICHD R01HD025787May 2, 1990 - Apr 30, 1993
    Role: Principal Investigator
    ANTIBODY V REGION REGULATION AND AUTOIMMUNITY
    NIH/NIAID R01AI023871Jul 1, 1986 - Jun 30, 1990
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rodvold JJ, Xian S, Nussbacher J, Tsui B, Cameron Waller T, Searles SC, Lew A, Jiang P, Babic I, Nomura N, Lin JH, Kesari S, Carter H, Zanetti M. IRE1a and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells. Sci Rep. 2020 May 20; 10(1):8348. PMID: 32433555.
      View in: PubMed
    2. Hiramatsu N, Chiang K, Aivati C, Rodvold JJ, Lee JM, Han J, Chea L, Zanetti M, Koo EH, Lin JH. PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response. J Biol Chem. 2020 Jan 03; 295(1):237-249. PMID: 31792031.
      View in: PubMed
    3. Castro A, Ozturk K, Pyke RM, Xian S, Zanetti M, Carter H. Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes. BMC Med Genomics. 2019 07 25; 12(Suppl 6):107. PMID: 31345234.
      View in: PubMed
    4. Marty Pyke R, Thompson WK, Salem RM, Font-Burgada J, Zanetti M, Carter H. Evolutionary Pressure against MHC Class II Binding Cancer Mutations. Cell. 2018 Dec 13; 175(7):1991. PMID: 30550793.
      View in: PubMed
    5. Almanza G, Rodvold JJ, Tsui B, Jepsen K, Carter H, Zanetti M. Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. Sci Rep. 2018 12 04; 8(1):17581. PMID: 30514916.
      View in: PubMed
    6. Marty Pyke R, Thompson WK, Salem RM, Font-Burgada J, Zanetti M, Carter H. Evolutionary Pressure against MHC Class II Binding Cancer Mutations. Cell. 2018 10 04; 175(2):416-428.e13. PMID: 30245014.
      View in: PubMed
    7. Rodvold JJ, Zanetti M. Insidious communication amongst cancer cells. Mol Cell Oncol. 2018; 5(3):e1356898. PMID: 30250884.
      View in: PubMed
    8. Kouznetsova VL, Hu H, Teigen K, Zanetti M, Tsigelny IF. Cripto stabilizes GRP78 on the cell membrane. Protein Sci. 2018 03; 27(3):653-661. PMID: 29226519.
      View in: PubMed
    9. Rodvold JJ, Kesari S, Zanetti M. A community affair in the tumor microenvironment. Oncotarget. 2017 Dec 05; 8(63):106173-106174. PMID: 29290938.
      View in: PubMed
    10. Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH, Zanetti M. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017 Jun 06; 10(482). PMID: 28588081.
      View in: PubMed
    11. Zanetti M. Chromosomal chaos silences immune surveillance. Science. 2017 01 20; 355(6322):249-250. PMID: 28104855.
      View in: PubMed
    12. Rodvold JJ, Zanetti M. Tumor microenvironment on the move and the Aselli connection. Sci Signal. 2016 06 28; 9(434):fs13. PMID: 27353363.
      View in: PubMed
    13. Zanetti M. A second chance for telomerase reverse transcriptase in anticancer immunotherapy. Nat Rev Clin Oncol. 2017 02; 14(2):115-128. PMID: 27245281.
      View in: PubMed
    14. Almanza G, Zanetti M. High-efficiency Generation of Multiple Short Noncoding RNA in B-cells and B-cell-derived Extracellular Vesicles. Mol Ther Nucleic Acids. 2015 Dec 15; 4:e271. PMID: 26670278.
      View in: PubMed
    15. Rodvold JJ, Mahadevan NR, Zanetti M. Immune modulation by ER stress and inflammation in the tumor microenvironment. Cancer Lett. 2016 09 28; 380(1):227-36. PMID: 26525580.
      View in: PubMed
    16. Zanetti M. Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics. J Immunol. 2015 Mar 01; 194(5):2049-56. PMID: 25710958.
      View in: PubMed
    17. Almanza G, Anufreichik V, Rodvold JJ, Chiu KT, DeLaney A, Akers JC, Chen CC, Zanetti M. Synthesis and delivery of short, noncoding RNA by B lymphocytes. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20182-7. PMID: 24277816.
      View in: PubMed
    18. Zanetti M. Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells. Ann N Y Acad Sci. 2013 May; 1284:6-11. PMID: 23651187.
      View in: PubMed
    19. Mahadevan NR, Rodvold JJ, Zanetti M. A Janus-faced role of the unfolded protein response in antitumor immunity. Oncoimmunology. 2013 May 01; 2(5):e23901. PMID: 23762789.
      View in: PubMed
    20. Mahadevan NR, Zanetti M. Sensing hyperploidy and immune surveillance: a pas-de-deux. Cell Cycle. 2013 Feb 15; 12(4):544-5. PMID: 23370385.
      View in: PubMed
    21. Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, Zanetti M. Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8? T cell priming. PLoS One. 2012; 7(12):e51845. PMID: 23272178.
      View in: PubMed
    22. Kumandan S, Mahadevan NR, Chiu K, DeLaney A, Zanetti M. Activation of the unfolded protein response bypasses trastuzumab-mediated inhibition of the PI-3K pathway. Cancer Lett. 2013 Feb 28; 329(2):236-42. PMID: 23200669.
      View in: PubMed
    23. Zanetti M, Mahadevan NR. Cancer. Immune surveillance from chromosomal chaos? Science. 2012 Sep 28; 337(6102):1616-7. PMID: 23019639.
      View in: PubMed
    24. Rodvold JJ, Mahadevan NR, Zanetti M. Lipocalin 2 in cancer: when good immunity goes bad. Cancer Lett. 2012 Mar 28; 316(2):132-8. PMID: 22075378.
      View in: PubMed
    25. Mahadevan NR, Zanetti M. Tumor stress inside out: cell-extrinsic effects of the unfolded protein response in tumor cells modulate the immunological landscape of the tumor microenvironment. J Immunol. 2011 Nov 01; 187(9):4403-9. PMID: 22013206.
      View in: PubMed
    26. Mahadevan NR, Rodvold J, Almanza G, Pérez AF, Wheeler MC, Zanetti M. ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-?B-dependent manner. BMC Cancer. 2011 Jun 07; 11:229. PMID: 21649922.
      View in: PubMed
    27. Mahadevan NR, Rodvold J, Sepulveda H, Rossi S, Drew AF, Zanetti M. Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6561-6. PMID: 21464300.
      View in: PubMed
    28. Franco A, Almanza G, Burns JC, Wheeler M, Zanetti M. Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones. Cell Immunol. 2010; 266(1):1-6. PMID: 20951371.
      View in: PubMed
    29. Mahadevan NR, Fernandez A, Rodvold JJ, Almanza G, Zanetti M. Prostate cancer cells undergoing ER stress in vitro and in vivo activate transcription of pro-inflammatory cytokines. J Inflamm Res. 2010; 3:99-103. PMID: 22096360.
      View in: PubMed
    30. Almanza G, Fernandez A, Volinia S, Cortez-Gonzalez X, Croce CM, Zanetti M. Selected microRNAs define cell fate determination of murine central memory CD8 T cells. PLoS One. 2010 Jun 22; 5(6):e11243. PMID: 20582165.
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    31. Zanetti M, Castiglioni P, Ingulli E. Principles of memory CD8 T-cells generation in relation to protective immunity. Adv Exp Med Biol. 2010; 684:108-25. PMID: 20795544.
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    32. Zanetti M, Schoenberger SP. Memory T Cells. Preface. Adv Exp Med Biol. 2010; 684:vii-ix. PMID: 20795535.
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    33. Cortez-Gonzalez X, Zanetti M. Identification of immunogenic peptides of the self-tumor antigen: our experience with telomerase reverse transcriptase. Methods Mol Biol. 2010; 651:211-25. PMID: 20686968.
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    34. Ingulli E, Funatake C, Jacovetty EL, Zanetti M. Cutting edge: antigen presentation to CD8 T cells after influenza A virus infection. J Immunol. 2009 Jan 01; 182(1):29-33. PMID: 19109130.
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    35. Pellicciotta I, Cortez-Gonzalez X, Sasik R, Reiter Y, Hardiman G, Langlade-Demoyen P, Zanetti M. Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. Cancer Res. 2008 Oct 01; 68(19):8085-93. PMID: 18829567.
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    36. Vaccari M, Mattapallil J, Song K, Tsai WP, Hryniewicz A, Venzon D, Zanetti M, Reimann KA, Roederer M, Franchini G. Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency. J Virol. 2008 Oct; 82(19):9629-38. PMID: 18667509.
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    37. Wheeler MC, Rizzi M, Sasik R, Almanza G, Hardiman G, Zanetti M. KDEL-retained antigen in B lymphocytes induces a proinflammatory response: a possible role for endoplasmic reticulum stress in adaptive T cell immunity. J Immunol. 2008 Jul 01; 181(1):256-64. PMID: 18566391.
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    38. Castiglioni P, Hall de S, Jacovetty EL, Ingulli E, Zanetti M. Protection against influenza A virus by memory CD8 T cells requires reactivation by bone marrow-derived dendritic cells. J Immunol. 2008 Apr 01; 180(7):4956-64. PMID: 18354221.
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    39. Chen SS, Barankiewicz T, Yang YM, Zanetti M, Hill P. Protection of IgE-mediated allergic sensitization by active immunization with IgE loops constrained in GFP protein scaffold. J Immunol Methods. 2008 Apr 20; 333(1-2):10-23. PMID: 18281056.
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    40. Frazzi R, Zanetti M. Plasmid DNA and IL-4 modulate expression of mHC class I and costimulatory molecules in B lymphocytes. DNA Cell Biol. 2007 Mar; 26(3):148-59. PMID: 17417943.
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    41. Cortez-Gonzalez X, Zanetti M. Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26; 5:12. PMID: 17324292.
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    42. Zanetti M. Immunity and protection, the unfolding of a tale. Immunol Res. 2007; 38(1-3):305-18. PMID: 17917038.
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    43. Cortez-Gonzalez X, Sidney J, Adotevi O, Sette A, Millard F, Lemonnier F, Langlade-Demoyen P, Zanetti M. Immunogenic HLA-B7-restricted peptides of hTRT. Int Immunol. 2006 Dec; 18(12):1707-18. PMID: 17077179.
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    44. Zanetti M, Franchini G. T cell memory and protective immunity by vaccination: is more better? Trends Immunol. 2006 Nov; 27(11):511-7. PMID: 16997631.
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    45. Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 2006 Sep; 119(1):98-115. PMID: 16836618.
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    46. Adotévi O, Mollier K, Neuveut C, Cardinaud S, Boulanger E, Mignen B, Fridman WH, Zanetti M, Charneau P, Tartour E, Lemonnier F, Langlade-Demoyen P. Immunogenic HLA-B*0702-restricted epitopes derived from human telomerase reverse transcriptase that elicit antitumor cytotoxic T-cell responses. Clin Cancer Res. 2006 May 15; 12(10):3158-67. PMID: 16707616.
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    47. Wheeler M, Cortez-Gonzalez X, Frazzi R, Zanetti M. Ex vivo programming of antigen-presenting B lymphocytes: considerations on DNA uptake and cell activation. Int Rev Immunol. 2006 May-Aug; 25(3-4):83-97. PMID: 16818366.
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    48. Cortez-Gonzalez X, Pellicciotta I, Gerloni M, Wheeler MC, Castiglioni P, Lenert P, Zanetti M. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol. 2006 May; 25(5):253-61. PMID: 16716115.
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    49. Gerloni M, Castiglioni P, Zanetti M. The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice. J Immunol. 2005 Nov 15; 175(10):6551-9. PMID: 16272309.
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    50. Zanetti M. T for two: when helpers need help. Autoimmun Rev. 2005 Nov; 4(8):571-8. PMID: 16214098.
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    51. Filaci G, Fravega M, Setti M, Traverso P, Millo E, Fenoglio D, Negrini S, Ferrera F, Romagnoli A, Basso M, Contini P, Rizzi M, Ghio M, Benatti U, Damonte G, Ravetti JL, Carmignani G, Zanetti M, Indiveri F. Frequency of telomerase-specific CD8+ T lymphocytes in patients with cancer. Blood. 2006 Feb 15; 107(4):1505-12. PMID: 16249379.
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    52. Vaccari M, Trindade CJ, Venzon D, Zanetti M, Franchini G. Vaccine-induced CD8+ central memory T cells in protection from simian AIDS. J Immunol. 2005 Sep 15; 175(6):3502-7. PMID: 16148092.
      View in: PubMed
    53. Rizzi M, Gerloni M, Srivastava AS, Wheeler MC, Schuler K, Carrier E, Zanetti M. In utero DNA immunisation. Immunity over tolerance in fetal life. Vaccine. 2005 Jul 21; 23(33):4273-82. PMID: 16005117.
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    54. Castiglioni P, Gerloni M, Cortez-Gonzalez X, Zanetti M. CD8 T cell priming by B lymphocytes is CD4 help dependent. Eur J Immunol. 2005 May; 35(5):1360-70. PMID: 15816014.
      View in: PubMed
    55. Gerloni M, Zanetti M. CD4 T cells in tumor immunity. Springer Semin Immunopathol. 2005 Jun; 27(1):37-48. PMID: 15965712.
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    56. Zanetti M, Hernandez X, Langlade-Demoyen P. Telomerase reverse transcriptase as target for anti-tumor T cell responses in humans. Springer Semin Immunopathol. 2005 Jun; 27(1):87-104. PMID: 15711953.
      View in: PubMed
    57. Chen SS, Gong J, Yang YM, Oettgen H, Zanetti M. Cytotoxic T-cells specific for natural IgE peptides downregulate IgE production. Cell Immunol. 2005 Jan; 233(1):11-22. PMID: 15913585.
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    58. Castiglioni P, Gerloni M, Zanetti M. Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells. Vaccine. 2004 Dec 16; 23(5):699-708. PMID: 15542193.
      View in: PubMed
    59. Musselli C, Daverio-Zanetti S, Zanetti M. Antigenized antibodies expressing Vbeta8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis. J Immune Based Ther Vaccines. 2004 Nov 12; 2(1):9. PMID: 15541175.
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    60. Hernández J, Schoeder K, Blondelle SE, Pons FG, Lone YC, Simora A, Langlade-Demoyen P, Wilson DB, Zanetti M. Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen. Eur J Immunol. 2004 Aug; 34(8):2331-41. PMID: 15259031.
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    61. Zanetti M, Castiglioni P, Rizzi M, Wheeler M, Gerloni M. B lymphocytes as antigen-presenting cell-based genetic vaccines. Immunol Rev. 2004 Jun; 199:264-78. PMID: 15233740.
      View in: PubMed
    62. Gerloni M, Rizzi M, Castiglioni P, Zanetti M. T cell immunity using transgenic B lymphocytes. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3892-7. PMID: 15004284.
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    63. Zanetti M, Castiglioni P, Schoenberger S, Gerloni M. The role of relB in regulating the adaptive immune response. Ann N Y Acad Sci. 2003 Apr; 987:249-57. PMID: 12727647.
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    64. Moss RB, Brandt C, Giermakowska WK, Savary JR, Theofan G, Zanetti M, Carlo DJ, Wallace MR. HIV-specific immunity during structured antiviral drug treatment interruption. Vaccine. 2003 Mar 07; 21(11-12):1066-71. PMID: 12559781.
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    65. Langlade-Demoyen P, Garcia-Pons F, Castiglioni P, Garcia Z, Cardinaud S, Xiong S, Gerloni M, Zanetti M. Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus. Eur J Immunol. 2003 Mar; 33(3):720-8. PMID: 12616492.
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    66. Filaci G, Contini P, Fravega M, Fenoglio D, Azzarone B, Julien-Giron M, Fiocca R, Boggio M, Necchi V, De Lerma Barbaro A, Merlo A, Rizzi M, Ghio M, Setti M, Puppo F, Zanetti M, Indiveri F. Apoptotic DNA binds to HLA class II molecules inhibiting antigen presentation and participating in the development of anti-inflammatory functional behavior of phagocytic macrophages. Hum Immunol. 2003 Jan; 64(1):9-20. PMID: 12507810.
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    67. Castiglioni P, Lu C, Lo D, Croft M, Langlade-Demoyen P, Zanetti M, Gerloni M. CD4 T cell priming in dendritic cell-deficient mice. Int Immunol. 2003 Jan; 15(1):127-36. PMID: 12502733.
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    68. Hernandez J, Garcia-Pons F, Lone YC, Firat H, Schmidt JD, Langlade-Demoyen P, Zanetti M. Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12275-80. PMID: 12218171.
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