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    Maurizio Zanetti

    TitleSenate Emeritus
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0815
    CA La Jolla 92093
    Phone858-822-5412
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      Collapse Research 
      Collapse Research Activities and Funding
      (PQ3) Disruption of immune surveillance by aneuploidy and aberrant MHCII expression
      NIH/NCI R01CA220009Aug 17, 2017 - Jul 31, 2022
      Role: Principal Investigator
      Phase 2 Study of Vascular-Targeted Prodrug (G-202) for the Treatment of Recurrent Glioblastoma
      FDA R01FD005077Apr 20, 2015 - Mar 31, 2019
      Role: Principal Investigator
      Targeting Cancer miRNAs by Adoptive Transfer of Programmed B Lymphocytes
      NIH/NCI R21CA178674Aug 1, 2014 - Jul 31, 2016
      Role: Principal Investigator
      Genetically-Programmed APC Vaccines Against Viruses
      NIH/NIAID R56AI062894Sep 30, 2011 - Sep 29, 2014
      Role: Principal Investigator
      Genetically-Programmed APC Vaccines Against Viruses
      NIH/NIAID R01AI062894Feb 1, 2005 - Jan 31, 2009
      Role: Principal Investigator
      Conformationally-Constrained PA Anthrax Vaccine
      NIH/NIAID R21AI057889Sep 30, 2004 - Aug 31, 2007
      Role: Principal Investigator
      Novel APC Vaccine to Induce Anti-Tumor T cell Immunity
      NIH/NCI R01CA092119Jul 1, 2002 - Jun 30, 2007
      Role: Principal Investigator
      Transgenic B-Cell Immunogenes
      NIH/NIAID R21AI049774May 1, 2001 - Apr 30, 2004
      Role: Principal Investigator
      TARGETED THERAPEUTIC VACCINATION IN PROSTATE CANCER
      NIH/NCI R01CA084062Jul 1, 2000 - Jun 30, 2005
      Role: Principal Investigator
      Strategies of Vaccination Against MUC.1 Antigen
      NIH/NCI R01CA077427Jul 23, 1999 - Nov 30, 2009
      Role: Principal Investigator
      ANTIGENIZED ANTIBODY AND GENE IN MALARIA VACCINE
      NIH/NIAID U01AI036467Sep 15, 1994 - Aug 31, 1997
      Role: Principal Investigator
      MODULATION OF PERIPHERIAL T CELLS ACTIVITY
      NIH/NIAID P01AI033204Sep 1, 1992 - Apr 30, 1996
      Role: Principal Investigator
      ENGINEERED CD4-LIKE ANTIBODIES IN NEONATAL HIV INFECTION
      NIH/NICHD R01HD025787May 2, 1990 - Apr 30, 1993
      Role: Principal Investigator
      ANTIBODY V REGION REGULATION AND AUTOIMMUNITY
      NIH/NIAID R01AI023871Jul 1, 1986 - Jun 30, 1990
      Role: Principal Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH, Zanetti M. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017 Jun 06; 10(482). PMID: 28588081.
        View in: PubMed
      2. Zanetti M. Chromosomal chaos silences immune surveillance. Science. 2017 01 20; 355(6322):249-250. PMID: 28104855.
        View in: PubMed
      3. Rodvold JJ, Zanetti M. Tumor microenvironment on the move and the Aselli connection. Sci Signal. 2016 Jun 28; 9(434):fs13. PMID: 27353363.
        View in: PubMed
      4. Zanetti M. A second chance for telomerase reverse transcriptase in anticancer immunotherapy. Nat Rev Clin Oncol. 2017 Feb; 14(2):115-128. PMID: 27245281.
        View in: PubMed
      5. Almanza G, Zanetti M. High-efficiency Generation of Multiple Short Noncoding RNA in B-cells and B-cell-derived Extracellular Vesicles. Mol Ther Nucleic Acids. 2015 Dec 15; 4:e271. PMID: 26670278.
        View in: PubMed
      6. Rodvold JJ, Mahadevan NR, Zanetti M. Immune modulation by ER stress and inflammation in the tumor microenvironment. Cancer Lett. 2016 Sep 28; 380(1):227-36. PMID: 26525580.
        View in: PubMed
      7. Zanetti M. Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics. J Immunol. 2015 Mar 01; 194(5):2049-56. PMID: 25710958.
        View in: PubMed
      8. Almanza G, Anufreichik V, Rodvold JJ, Chiu KT, DeLaney A, Akers JC, Chen CC, Zanetti M. Synthesis and delivery of short, noncoding RNA by B lymphocytes. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20182-7. PMID: 24277816; PMCID: PMC3864290.
        View in: PubMed, PubMed Central
      9. Fenoglio D, Traverso P, Parodi A, Kalli F, Zanetti M, Filaci G. Generation of more effective cancer vaccines. Hum Vaccin Immunother. 2013 Dec; 9(12):2543-7. PMID: 23978951; PMCID: PMC4162041.
        View in: PubMed, PubMed Central
      10. Mahadevan NR, Rodvold JJ, Zanetti M. A Janus-faced role of the unfolded protein response in antitumor immunity. Oncoimmunology. 2013 May 01; 2(5):e23901. PMID: 23762789.
        View in: PubMed
      11. Zanetti M. Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells. Ann N Y Acad Sci. 2013 May; 1284:6-11. PMID: 23651187.
        View in: PubMed
      12. Mahadevan NR, Zanetti M. Sensing hyperploidy and immune surveillance: a pas-de-deux. Cell Cycle. 2013 Feb 15; 12(4):544-5. PMID: 23370385; PMCID: PMC3594253.
        View in: PubMed, PubMed Central
      13. Kumandan S, Mahadevan NR, Chiu K, DeLaney A, Zanetti M. Activation of the unfolded protein response bypasses trastuzumab-mediated inhibition of the PI-3K pathway. Cancer Lett. 2013 Feb 28; 329(2):236-42. PMID: 23200669; PMCID: PMC4091625.
        View in: PubMed, PubMed Central
      14. Zanetti M, Mahadevan NR. Cancer. Immune surveillance from chromosomal chaos? Science. 2012 Sep 28; 337(6102):1616-7. PMID: 23019639.
        View in: PubMed
      15. Rodvold JJ, Mahadevan NR, Zanetti M. Lipocalin 2 in cancer: when good immunity goes bad. Cancer Lett. 2012 Mar 28; 316(2):132-8. PMID: 22075378.
        View in: PubMed
      16. Mahadevan NR, Zanetti M. Tumor stress inside out: cell-extrinsic effects of the unfolded protein response in tumor cells modulate the immunological landscape of the tumor microenvironment. J Immunol. 2011 Nov 01; 187(9):4403-9. PMID: 22013206.
        View in: PubMed
      17. Mahadevan NR, Rodvold J, Almanza G, Pérez AF, Wheeler MC, Zanetti M. ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-?B-dependent manner. BMC Cancer. 2011 Jun 07; 11:229. PMID: 21649922; PMCID: PMC3146445.
        View in: PubMed, PubMed Central
      18. Mahadevan NR, Rodvold J, Sepulveda H, Rossi S, Drew AF, Zanetti M. Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6561-6. PMID: 21464300; PMCID: PMC3081038.
        View in: PubMed, PubMed Central
      19. Franco A, Almanza G, Burns JC, Wheeler M, Zanetti M. Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones. Cell Immunol. 2010; 266(1):1-6. PMID: 20951371.
        View in: PubMed
      20. Mahadevan NR, Fernandez A, Rodvold JJ, Almanza G, Zanetti M. Prostate cancer cells undergoing ER stress in vitro and in vivo activate transcription of pro-inflammatory cytokines. J Inflamm Res. 2010; 3:99-103. PMID: 22096360; PMCID: PMC3218737.
        View in: PubMed, PubMed Central
      21. Almanza G, Fernandez A, Volinia S, Cortez-Gonzalez X, Croce CM, Zanetti M. Selected microRNAs define cell fate determination of murine central memory CD8 T cells. PLoS One. 2010 Jun 22; 5(6):e11243. PMID: 20582165; PMCID: PMC2889817.
        View in: PubMed, PubMed Central
      22. Cortez-Gonzalez X, Zanetti M. Identification of immunogenic peptides of the self-tumor antigen: our experience with telomerase reverse transcriptase. Methods Mol Biol. 2010; 651:211-25. PMID: 20686968.
        View in: PubMed
      23. Zanetti M, Schoenberger SP. Memory T Cells. Preface. Adv Exp Med Biol. 2010; 684:vii-ix. PMID: 20795535.
        View in: PubMed
      24. Zanetti M, Castiglioni P, Ingulli E. Principles of memory CD8 T-cells generation in relation to protective immunity. Adv Exp Med Biol. 2010; 684:108-25. PMID: 20795544.
        View in: PubMed
      25. Ingulli E, Funatake C, Jacovetty EL, Zanetti M. Cutting edge: antigen presentation to CD8 T cells after influenza A virus infection. J Immunol. 2009 Jan 01; 182(1):29-33. PMID: 19109130.
        View in: PubMed
      26. Pellicciotta I, Cortez-Gonzalez X, Sasik R, Reiter Y, Hardiman G, Langlade-Demoyen P, Zanetti M. Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. Cancer Res. 2008 Oct 01; 68(19):8085-93. PMID: 18829567.
        View in: PubMed
      27. Vaccari M, Mattapallil J, Song K, Tsai WP, Hryniewicz A, Venzon D, Zanetti M, Reimann KA, Roederer M, Franchini G. Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency. J Virol. 2008 Oct; 82(19):9629-38. PMID: 18667509; PMCID: PMC2546957.
        View in: PubMed, PubMed Central
      28. Wheeler MC, Rizzi M, Sasik R, Almanza G, Hardiman G, Zanetti M. KDEL-retained antigen in B lymphocytes induces a proinflammatory response: a possible role for endoplasmic reticulum stress in adaptive T cell immunity. J Immunol. 2008 Jul 01; 181(1):256-64. PMID: 18566391.
        View in: PubMed
      29. Castiglioni P, Hall de S, Jacovetty EL, Ingulli E, Zanetti M. Protection against influenza A virus by memory CD8 T cells requires reactivation by bone marrow-derived dendritic cells. J Immunol. 2008 Apr 01; 180(7):4956-64. PMID: 18354221.
        View in: PubMed
      30. Chen SS, Barankiewicz T, Yang YM, Zanetti M, Hill P. Protection of IgE-mediated allergic sensitization by active immunization with IgE loops constrained in GFP protein scaffold. J Immunol Methods. 2008 Apr 20; 333(1-2):10-23. PMID: 18281056.
        View in: PubMed
      31. Frazzi R, Zanetti M. Plasmid DNA and IL-4 modulate expression of mHC class I and costimulatory molecules in B lymphocytes. DNA Cell Biol. 2007 Mar; 26(3):148-59. PMID: 17417943.
        View in: PubMed
      32. Cortez-Gonzalez X, Zanetti M. Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26; 5:12. PMID: 17324292; PMCID: PMC1839079.
        View in: PubMed, PubMed Central
      33. Zanetti M. Immunity and protection, the unfolding of a tale. Immunol Res. 2007; 38(1-3):305-18. PMID: 17917038.
        View in: PubMed
      34. Cortez-Gonzalez X, Sidney J, Adotevi O, Sette A, Millard F, Lemonnier F, Langlade-Demoyen P, Zanetti M. Immunogenic HLA-B7-restricted peptides of hTRT. Int Immunol. 2006 Dec; 18(12):1707-18. PMID: 17077179.
        View in: PubMed
      35. Zanetti M, Franchini G. T cell memory and protective immunity by vaccination: is more better? Trends Immunol. 2006 Nov; 27(11):511-7. PMID: 16997631.
        View in: PubMed
      36. Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 2006 Sep; 119(1):98-115. PMID: 16836618; PMCID: PMC1782333.
        View in: PubMed, PubMed Central
      37. Adotévi O, Mollier K, Neuveut C, Cardinaud S, Boulanger E, Mignen B, Fridman WH, Zanetti M, Charneau P, Tartour E, Lemonnier F, Langlade-Demoyen P. Immunogenic HLA-B*0702-restricted epitopes derived from human telomerase reverse transcriptase that elicit antitumor cytotoxic T-cell responses. Clin Cancer Res. 2006 May 15; 12(10):3158-67. PMID: 16707616.
        View in: PubMed
      38. Wheeler M, Cortez-Gonzalez X, Frazzi R, Zanetti M. Ex vivo programming of antigen-presenting B lymphocytes: considerations on DNA uptake and cell activation. Int Rev Immunol. 2006 May-Aug; 25(3-4):83-97. PMID: 16818366.
        View in: PubMed
      39. Cortez-Gonzalez X, Pellicciotta I, Gerloni M, Wheeler MC, Castiglioni P, Lenert P, Zanetti M. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol. 2006 May; 25(5):253-61. PMID: 16716115.
        View in: PubMed
      40. Gerloni M, Castiglioni P, Zanetti M. The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice. J Immunol. 2005 Nov 15; 175(10):6551-9. PMID: 16272309.
        View in: PubMed
      41. Zanetti M. T for two: when helpers need help. Autoimmun Rev. 2005 Nov; 4(8):571-8. PMID: 16214098.
        View in: PubMed
      42. Filaci G, Fravega M, Setti M, Traverso P, Millo E, Fenoglio D, Negrini S, Ferrera F, Romagnoli A, Basso M, Contini P, Rizzi M, Ghio M, Benatti U, Damonte G, Ravetti JL, Carmignani G, Zanetti M, Indiveri F. Frequency of telomerase-specific CD8+ T lymphocytes in patients with cancer. Blood. 2006 Feb 15; 107(4):1505-12. PMID: 16249379.
        View in: PubMed
      43. Vaccari M, Trindade CJ, Venzon D, Zanetti M, Franchini G. Vaccine-induced CD8+ central memory T cells in protection from simian AIDS. J Immunol. 2005 Sep 15; 175(6):3502-7. PMID: 16148092.
        View in: PubMed
      44. Rizzi M, Gerloni M, Srivastava AS, Wheeler MC, Schuler K, Carrier E, Zanetti M. In utero DNA immunisation. Immunity over tolerance in fetal life. Vaccine. 2005 Jul 21; 23(33):4273-82. PMID: 16005117.
        View in: PubMed
      45. Castiglioni P, Gerloni M, Cortez-Gonzalez X, Zanetti M. CD8 T cell priming by B lymphocytes is CD4 help dependent. Eur J Immunol. 2005 May; 35(5):1360-70. PMID: 15816014.
        View in: PubMed
      46. Gerloni M, Zanetti M. CD4 T cells in tumor immunity. Springer Semin Immunopathol. 2005 Jun; 27(1):37-48. PMID: 15965712.
        View in: PubMed
      47. Zanetti M, Hernandez X, Langlade-Demoyen P. Telomerase reverse transcriptase as target for anti-tumor T cell responses in humans. Springer Semin Immunopathol. 2005 Jun; 27(1):87-104. PMID: 15711953.
        View in: PubMed
      48. Chen SS, Gong J, Yang YM, Oettgen H, Zanetti M. Cytotoxic T-cells specific for natural IgE peptides downregulate IgE production. Cell Immunol. 2005 Jan; 233(1):11-22. PMID: 15913585.
        View in: PubMed
      49. Castiglioni P, Gerloni M, Zanetti M. Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells. Vaccine. 2004 Dec 16; 23(5):699-708. PMID: 15542193.
        View in: PubMed
      50. Musselli C, Daverio-Zanetti S, Zanetti M. Antigenized antibodies expressing Vbeta8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis. J Immune Based Ther Vaccines. 2004 Nov 12; 2(1):9. PMID: 15541175.
        View in: PubMed
      51. Hernández J, Schoeder K, Blondelle SE, Pons FG, Lone YC, Simora A, Langlade-Demoyen P, Wilson DB, Zanetti M. Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen. Eur J Immunol. 2004 Aug; 34(8):2331-41. PMID: 15259031.
        View in: PubMed
      52. Zanetti M, Castiglioni P, Rizzi M, Wheeler M, Gerloni M. B lymphocytes as antigen-presenting cell-based genetic vaccines. Immunol Rev. 2004 Jun; 199:264-78. PMID: 15233740.
        View in: PubMed
      53. Gerloni M, Rizzi M, Castiglioni P, Zanetti M. T cell immunity using transgenic B lymphocytes. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3892-7. PMID: 15004284; PMCID: PMC374340.
        View in: PubMed, PubMed Central
      54. Zanetti M, Castiglioni P, Schoenberger S, Gerloni M. The role of relB in regulating the adaptive immune response. Ann N Y Acad Sci. 2003 Apr; 987:249-57. PMID: 12727647.
        View in: PubMed
      55. Moss RB, Brandt C, Giermakowska WK, Savary JR, Theofan G, Zanetti M, Carlo DJ, Wallace MR. HIV-specific immunity during structured antiviral drug treatment interruption. Vaccine. 2003 Mar 07; 21(11-12):1066-71. PMID: 12559781.
        View in: PubMed
      56. Langlade-Demoyen P, Garcia-Pons F, Castiglioni P, Garcia Z, Cardinaud S, Xiong S, Gerloni M, Zanetti M. Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus. Eur J Immunol. 2003 Mar; 33(3):720-8. PMID: 12616492.
        View in: PubMed
      57. Filaci G, Contini P, Fravega M, Fenoglio D, Azzarone B, Julien-Giron M, Fiocca R, Boggio M, Necchi V, De Lerma Barbaro A, Merlo A, Rizzi M, Ghio M, Setti M, Puppo F, Zanetti M, Indiveri F. Apoptotic DNA binds to HLA class II molecules inhibiting antigen presentation and participating in the development of anti-inflammatory functional behavior of phagocytic macrophages. Hum Immunol. 2003 Jan; 64(1):9-20. PMID: 12507810.
        View in: PubMed
      58. Castiglioni P, Lu C, Lo D, Croft M, Langlade-Demoyen P, Zanetti M, Gerloni M. CD4 T cell priming in dendritic cell-deficient mice. Int Immunol. 2003 Jan; 15(1):127-36. PMID: 12502733.
        View in: PubMed
      59. Hernandez J, Garcia-Pons F, Lone YC, Firat H, Schmidt JD, Langlade-Demoyen P, Zanetti M. Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12275-80. PMID: 12218171; PMCID: PMC129435.
        View in: PubMed, PubMed Central
      60. Castiglioni P, Janssen EM, Prilliman KR, Gerloni M, Schoenberger S, Zanetti M. Cross-priming is under control of the relB gene. Scand J Immunol. 2002 Sep; 56(3):219-23. PMID: 12193222.
        View in: PubMed
      61. Schuler K, Lu C, Chang HD, Croft M, Zanetti M, Gerloni M. Circumvention of MHC class II restriction by genetic immunization. Vaccine. 2001 Nov 12; 20(3-4):630-4. PMID: 11672931.
        View in: PubMed
      62. Gerloni M, Xiong S, Mukerjee S, Schoenberger SP, Croft M, Zanetti M. Functional cooperation between T helper cell determinants. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13269-74. PMID: 11069291; PMCID: PMC27214.
        View in: PubMed, PubMed Central
      63. Minev B, Hipp J, Firat H, Schmidt JD, Langlade-Demoyen P, Zanetti M. Cytotoxic T cell immunity against telomerase reverse transcriptase in humans. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4796-801. PMID: 10759561; PMCID: PMC18312.
        View in: PubMed, PubMed Central
      64. Gerloni M, Miner KT, Xiong S, Croft M, Zanetti M. Activation of CD4 T cells by somatic transgenesis induces generalized immunity of uncommitted T cells and immunologic memory. J Immunol. 1999 Apr 01; 162(7):3782-9. PMID: 10201894.
        View in: PubMed
      65. Rossi F, Billetta R, Ruggeri Z, Zanetti M. Engineered idiotypes. Immunochemical analysis of antigenized antibodies expressing a conformationally constrained Arg-Gly-Asp motif. Mol Immunol. 1995 Apr; 32(5):341-6. PMID: 7739571.
        View in: PubMed
      66. Mehta RL, Lenert P, Zanetti M. Synthetic peptides of human CD4 enhance binding of immunoglobulins to monocyte/macrophage cells. II. Mechanisms of enhancement. Cell Immunol. 1994 Jun; 156(1):146-54. PMID: 8200032.
        View in: PubMed
      67. Zanetti M, Filaci G, Lee RH, del Guercio P, Rossi F, Bacchetta R, Stevenson F, Barnaba V, Billetta R. Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif. EMBO J. 1993 Nov; 12(11):4375-84. PMID: 8223447; PMCID: PMC413734.
        View in: PubMed, PubMed Central
      68. Zanetti M, Rossi F, Lanza P, Filaci G, Lee RH, Billetta R. Theoretical and practical aspects of antigenized antibodies. Immunol Rev. 1992 Dec; 130:125-50. PMID: 1286868.
        View in: PubMed
      69. Lenert P, Mehta RL, Zanetti M. Synthetic peptides of human CD4 enhance binding of Ig to monocyte/macrophage cells. I. Characterization and mapping studies. J Immunol. 1992 Mar 15; 148(6):1759-63. PMID: 1541816.
        View in: PubMed
      70. Lenert P, Kroon D, Spiegelberg H, Golub ES, Zanetti M. Human CD4 binds immunoglobulins. Science. 1990 Jun 29; 248(4963):1639-43. PMID: 2363051.
        View in: PubMed
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