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Maurizio Zanetti

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    (PQ3) Disruption of immune surveillance by aneuploidy and aberrant MHCII expression
    NIH/NCI R01CA220009Aug 17, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Phase 2 Study of Vascular-Targeted Prodrug (G-202) for the Treatment of Recurrent Glioblastoma
    FDA R01FD005077Apr 20, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Targeting Cancer miRNAs by Adoptive Transfer of Programmed B Lymphocytes
    NIH/NCI R21CA178674Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Genetically-Programmed APC Vaccines Against Viruses
    NIH/NIAID R56AI062894Sep 30, 2011 - Sep 29, 2014
    Role: Principal Investigator
    Genetically-Programmed APC Vaccines Against Viruses
    NIH/NIAID R01AI062894Feb 1, 2005 - Jan 31, 2009
    Role: Principal Investigator
    Conformationally-Constrained PA Anthrax Vaccine
    NIH/NIAID R21AI057889Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Novel APC Vaccine to Induce Anti-Tumor T cell Immunity
    NIH/NCI R01CA092119Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    Transgenic B-Cell Immunogenes
    NIH/NIAID R21AI049774May 1, 2001 - Apr 30, 2004
    Role: Principal Investigator
    TARGETED THERAPEUTIC VACCINATION IN PROSTATE CANCER
    NIH/NCI R01CA084062Jul 1, 2000 - Jun 30, 2005
    Role: Principal Investigator
    Strategies of Vaccination Against MUC.1 Antigen
    NIH/NCI R01CA077427Jul 23, 1999 - Nov 30, 2009
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    ANTIGENIZED ANTIBODY AND GENE IN MALARIA VACCINE
    NIH/NIAID U01AI036467Sep 15, 1994 - Aug 31, 1997
    Role: Principal Investigator
    MODULATION OF PERIPHERIAL T CELLS ACTIVITY
    NIH/NIAID P01AI033204Sep 1, 1992 - Apr 30, 1996
    Role: Principal Investigator
    ENGINEERED CD4-LIKE ANTIBODIES IN NEONATAL HIV INFECTION
    NIH/NICHD R01HD025787May 2, 1990 - Apr 30, 1993
    Role: Principal Investigator
    ANTIBODY V REGION REGULATION AND AUTOIMMUNITY
    NIH/NIAID R01AI023871Jul 1, 1986 - Jun 30, 1990
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Strength of immune selection in tumors varies with sex and age. Nat Commun. 2020 Aug 17; 11(1):4128. Castro A, Pyke RM, Zhang X, Thompson WK, Day CP, Alexandrov LB, Zanetti M, Carter H. PMID: 32807809.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Telomerase and CD4 T Cell Immunity in Cancer. Cancers (Basel). 2020 Jun 25; 12(6). Dosset M, Castro A, Carter H, Zanetti M. PMID: 32630460.
      View in: PubMed   Mentions:
    3. IRE1a regulates macrophage polarization, PD-L1 expression, and tumor survival. PLoS Biol. 2020 06; 18(6):e3000687. Batista A, Rodvold JJ, Xian S, Searles SC, Lew A, Iwawaki T, Almanza G, Waller TC, Lin J, Jepsen K, Carter H, Zanetti M. PMID: 32520957.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. IRE1a and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells. Sci Rep. 2020 05 20; 10(1):8348. Rodvold JJ, Xian S, Nussbacher J, Tsui B, Cameron Waller T, Searles SC, Lew A, Jiang P, Babic I, Nomura N, Lin JH, Kesari S, Carter H, Zanetti M. PMID: 32433555.
      View in: PubMed   Mentions:    Fields:    
    5. PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response. J Biol Chem. 2020 01 03; 295(1):237-249. Hiramatsu N, Chiang K, Aivati C, Rodvold JJ, Lee JM, Han J, Chea L, Zanetti M, Koo EH, Lin JH. PMID: 31792031.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes. BMC Med Genomics. 2019 07 25; 12(Suppl 6):107. Castro A, Ozturk K, Pyke RM, Xian S, Zanetti M, Carter H. PMID: 31345234.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. Sci Rep. 2018 12 04; 8(1):17581. Almanza G, Rodvold JJ, Tsui B, Jepsen K, Carter H, Zanetti M. PMID: 30514916.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Evolutionary Pressure against MHC Class II Binding Cancer Mutations. Cell. 2018 10 04; 175(2):416-428.e13. Marty Pyke R, Thompson WK, Salem RM, Font-Burgada J, Zanetti M, Carter H. PMID: 30245014.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    9. Insidious communication amongst cancer cells. Mol Cell Oncol. 2018; 5(3):e1356898. Rodvold JJ, Zanetti M. PMID: 30250884.
      View in: PubMed   Mentions:
    10. Cripto stabilizes GRP78 on the cell membrane. Protein Sci. 2018 03; 27(3):653-661. Kouznetsova VL, Hu H, Teigen K, Zanetti M, Tsigelny IF. PMID: 29226519.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. A community affair in the tumor microenvironment. Oncotarget. 2017 Dec 05; 8(63):106173-106174. Rodvold JJ, Kesari S, Zanetti M. PMID: 29290938.
      View in: PubMed   Mentions:    Fields:    
    12. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017 Jun 06; 10(482). Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH, Zanetti M. PMID: 28588081.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    13. Chromosomal chaos silences immune surveillance. Science. 2017 01 20; 355(6322):249-250. Zanetti M. PMID: 28104855.
      View in: PubMed   Mentions: 2     Fields:    
    14. Tumor microenvironment on the move and the Aselli connection. Sci Signal. 2016 06 28; 9(434):fs13. Rodvold JJ, Zanetti M. PMID: 27353363.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. A second chance for telomerase reverse transcriptase in anticancer immunotherapy. Nat Rev Clin Oncol. 2017 02; 14(2):115-128. Zanetti M. PMID: 27245281.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    16. High-efficiency Generation of Multiple Short Noncoding RNA in B-cells and B-cell-derived Extracellular Vesicles. Mol Ther Nucleic Acids. 2015 Dec 15; 4:e271. Almanza G, Zanetti M. PMID: 26670278.
      View in: PubMed   Mentions:
    17. Immune modulation by ER stress and inflammation in the tumor microenvironment. Cancer Lett. 2016 09 28; 380(1):227-36. Rodvold JJ, Mahadevan NR, Zanetti M. PMID: 26525580.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics. J Immunol. 2015 Mar 01; 194(5):2049-56. Zanetti M. PMID: 25710958.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    19. Synthesis and delivery of short, noncoding RNA by B lymphocytes. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20182-7. Almanza G, Anufreichik V, Rodvold JJ, Chiu KT, DeLaney A, Akers JC, Chen CC, Zanetti M. PMID: 24277816.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. A Janus-faced role of the unfolded protein response in antitumor immunity. Oncoimmunology. 2013 May 01; 2(5):e23901. Mahadevan NR, Rodvold JJ, Zanetti M. PMID: 23762789.
      View in: PubMed   Mentions:
    21. Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells. Ann N Y Acad Sci. 2013 May; 1284:6-11. Zanetti M. PMID: 23651187.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Sensing hyperploidy and immune surveillance: a pas-de-deux. . 2013 Feb 15; 12(4):544-5. Mahadevan NR, Zanetti M. PMID: 23370385.
      View in: PubMed   Mentions:
    23. Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8? T cell priming. PLoS One. 2012; 7(12):e51845. Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, Zanetti M. PMID: 23272178.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    24. Activation of the unfolded protein response bypasses trastuzumab-mediated inhibition of the PI-3K pathway. Cancer Lett. 2013 Feb 28; 329(2):236-42. Kumandan S, Mahadevan NR, Chiu K, DeLaney A, Zanetti M. PMID: 23200669.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    25. Cancer. Immune surveillance from chromosomal chaos? Science. 2012 Sep 28; 337(6102):1616-7. Zanetti M, Mahadevan NR. PMID: 23019639.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    26. Lipocalin 2 in cancer: when good immunity goes bad. Cancer Lett. 2012 Mar 28; 316(2):132-8. Rodvold JJ, Mahadevan NR, Zanetti M. PMID: 22075378.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    27. Tumor stress inside out: cell-extrinsic effects of the unfolded protein response in tumor cells modulate the immunological landscape of the tumor microenvironment. J Immunol. 2011 Nov 01; 187(9):4403-9. Mahadevan NR, Zanetti M. PMID: 22013206.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-?B-dependent manner. BMC Cancer. 2011 Jun 07; 11:229. Mahadevan NR, Rodvold J, Almanza G, Pérez AF, Wheeler MC, Zanetti M. PMID: 21649922.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    29. Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6561-6. Mahadevan NR, Rodvold J, Sepulveda H, Rossi S, Drew AF, Zanetti M. PMID: 21464300.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    30. Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones. Cell Immunol. 2010; 266(1):1-6. Franco A, Almanza G, Burns JC, Wheeler M, Zanetti M. PMID: 20951371.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    31. Prostate cancer cells undergoing ER stress in vitro and in vivo activate transcription of pro-inflammatory cytokines. J Inflamm Res. 2010; 3:99-103. Mahadevan NR, Fernandez A, Rodvold JJ, Almanza G, Zanetti M. PMID: 22096360.
      View in: PubMed   Mentions:
    32. Selected microRNAs define cell fate determination of murine central memory CD8 T cells. PLoS One. 2010 Jun 22; 5(6):e11243. Almanza G, Fernandez A, Volinia S, Cortez-Gonzalez X, Croce CM, Zanetti M. PMID: 20582165.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. Principles of memory CD8 T-cells generation in relation to protective immunity. Adv Exp Med Biol. 2010; 684:108-25. Zanetti M, Castiglioni P, Ingulli E. PMID: 20795544.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    34. Identification of immunogenic peptides of the self-tumor antigen: our experience with telomerase reverse transcriptase. Methods Mol Biol. 2010; 651:211-25. Cortez-Gonzalez X, Zanetti M. PMID: 20686968.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    35. Cutting edge: antigen presentation to CD8 T cells after influenza A virus infection. J Immunol. 2009 Jan 01; 182(1):29-33. Ingulli E, Funatake C, Jacovetty EL, Zanetti M. PMID: 19109130.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    36. KDEL-retained antigen in B lymphocytes induces a proinflammatory response: a possible role for endoplasmic reticulum stress in adaptive T cell immunity. J Immunol. 2008 Jul 01; 181(1):256-64. Wheeler MC, Rizzi M, Sasik R, Almanza G, Hardiman G, Zanetti M. PMID: 18566391.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    37. Protection against influenza A virus by memory CD8 T cells requires reactivation by bone marrow-derived dendritic cells. J Immunol. 2008 Apr 01; 180(7):4956-64. Castiglioni P, Hall de S, Jacovetty EL, Ingulli E, Zanetti M. PMID: 18354221.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Plasmid DNA and IL-4 modulate expression of mHC class I and costimulatory molecules in B lymphocytes. DNA Cell Biol. 2007 Mar; 26(3):148-59. Frazzi R, Zanetti M. PMID: 17417943.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    39. Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26; 5:12. Cortez-Gonzalez X, Zanetti M. PMID: 17324292.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    40. Immunity and protection, the unfolding of a tale. Immunol Res. 2007; 38(1-3):305-18. Zanetti M. PMID: 17917038.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    41. Immunogenic HLA-B7-restricted peptides of hTRT. Int Immunol. 2006 Dec; 18(12):1707-18. Cortez-Gonzalez X, Sidney J, Adotevi O, Sette A, Millard F, Lemonnier F, Langlade-Demoyen P, Zanetti M. PMID: 17077179.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. T cell memory and protective immunity by vaccination: is more better? Trends Immunol. 2006 Nov; 27(11):511-7. Zanetti M, Franchini G. PMID: 16997631.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 2006 Sep; 119(1):98-115. Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. PMID: 16836618.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol. 2006 May; 25(5):253-61. Cortez-Gonzalez X, Pellicciotta I, Gerloni M, Wheeler MC, Castiglioni P, Lenert P, Zanetti M. PMID: 16716115.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Ex vivo programming of antigen-presenting B lymphocytes: considerations on DNA uptake and cell activation. Int Rev Immunol. 2006 May-Aug; 25(3-4):83-97. Wheeler M, Cortez-Gonzalez X, Frazzi R, Zanetti M. PMID: 16818366.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    46. The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice. J Immunol. 2005 Nov 15; 175(10):6551-9. Gerloni M, Castiglioni P, Zanetti M. PMID: 16272309.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    47. T for two: when helpers need help. Autoimmun Rev. 2005 Nov; 4(8):571-8. Zanetti M. PMID: 16214098.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. In utero DNA immunisation. Immunity over tolerance in fetal life. Vaccine. 2005 Jul 21; 23(33):4273-82. Rizzi M, Gerloni M, Srivastava AS, Wheeler MC, Schuler K, Carrier E, Zanetti M. PMID: 16005117.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    49. CD8 T cell priming by B lymphocytes is CD4 help dependent. Eur J Immunol. 2005 May; 35(5):1360-70. Castiglioni P, Gerloni M, Cortez-Gonzalez X, Zanetti M. PMID: 15816014.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. CD4 T cells in tumor immunity. Springer Semin Immunopathol. 2005 Jun; 27(1):37-48. Gerloni M, Zanetti M. PMID: 15965712.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    51. Telomerase reverse transcriptase as target for anti-tumor T cell responses in humans. Springer Semin Immunopathol. 2005 Jun; 27(1):87-104. Zanetti M, Hernandez X, Langlade-Demoyen P. PMID: 15711953.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    52. Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells. Vaccine. 2004 Dec 16; 23(5):699-708. Castiglioni P, Gerloni M, Zanetti M. PMID: 15542193.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. Antigenized antibodies expressing Vbeta8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis. J Immune Based Ther Vaccines. 2004 Nov 12; 2(1):9. Musselli C, Daverio-Zanetti S, Zanetti M. PMID: 15541175.
      View in: PubMed   Mentions:
    54. Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen. Eur J Immunol. 2004 Aug; 34(8):2331-41. Hernández J, Schoeder K, Blondelle SE, Pons FG, Lone YC, Simora A, Langlade-Demoyen P, Wilson DB, Zanetti M. PMID: 15259031.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    55. B lymphocytes as antigen-presenting cell-based genetic vaccines. Immunol Rev. 2004 Jun; 199:264-78. Zanetti M, Castiglioni P, Rizzi M, Wheeler M, Gerloni M. PMID: 15233740.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    56. T cell immunity using transgenic B lymphocytes. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3892-7. Gerloni M, Rizzi M, Castiglioni P, Zanetti M. PMID: 15004284.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    57. The role of relB in regulating the adaptive immune response. Ann N Y Acad Sci. 2003 Apr; 987:249-57. Zanetti M, Castiglioni P, Schoenberger S, Gerloni M. PMID: 12727647.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. CD4 T cell priming in dendritic cell-deficient mice. Int Immunol. 2003 Jan; 15(1):127-36. Castiglioni P, Lu C, Lo D, Croft M, Langlade-Demoyen P, Zanetti M, Gerloni M. PMID: 12502733.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    59. Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12275-80. Hernandez J, Garcia-Pons F, Lone YC, Firat H, Schmidt JD, Langlade-Demoyen P, Zanetti M. PMID: 12218171.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
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