Lingzhi Zhang

Title(s)Staff Res Assoc, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
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    AACR2009Glaxosmithkline outstanding clinical scholar award

    Collapse Research 
    Collapse Research Activities and Funding
    Cyclic nucleotide phosphodiesterases isoforms as novel biomarkers in CLL
    NIH R21CA139244Jun 1, 2009 - May 31, 2012
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ibuprofen inhibits key genes involved in androgen production in theca–interstitial cells. F&S Science. 2021; 2(3):230-236. Chelsea W.FoxM.D.aLingzhiZhangPh.D.bBenjamin C.MoellerPh.D.cV. GabrielGarzoM.D.dR. JeffreyChangM.D.bAntoni J.DulebaM.D.b. View Publication.
    2. Androgens Modulate Rat Granulosa Cell Steroidogenesis. Reprod Sci. 2020 04; 27(4):1002-1007. Doblado M, Zhang L, Toloubeydokhti T, Garzo GT, Chang RJ, Duleba AJ. PMID: 31916094; PMCID: PMC7539820.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Inflammatory Stimuli Trigger Increased Androgen Production and Shifts in Gene Expression in Theca-Interstitial Cells. Endocrinology. 2019 12 01; 160(12):2946-2958. Fox CW, Zhang L, Sohni A, Doblado M, Wilkinson MF, Chang RJ, Duleba AJ. PMID: 31599939; PMCID: PMC6855291.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    4. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol. 2018; 9:431. Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. PMID: 29872392; PMCID: PMC5972277.
      View in: PubMed   Mentions: 57  
    5. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188; PMCID: PMC4571978.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Mol Pharmacol. 2015 Jul; 88(1):181-7. Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. PMID: 25737495; PMCID: PMC4468643.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    7. A novel immunocompetent murine model for replicating oncolytic adenoviral therapy. Cancer Gene Ther. 2015 Jan; 22(1):17-22. Zhang L, Hedjran F, Larson C, Perez GL, Reid T. PMID: 25525035; PMCID: PMC4298785.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    8. Encapsulation of adenovirus serotype 5 in anionic lecithin liposomes using a bead-based immunoprecipitation technique enhances transfection efficiency. Biomaterials. 2014 Nov; 35(35):9554-61. Mendez N, Herrera V, Zhang L, Hedjran F, Feuer R, Blair SL, Trogler WC, Reid TR, Kummel AC. PMID: 25154663; PMCID: PMC4157089.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    9. Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells. Horm Metab Res. 2014 Nov; 46(12):854-62. Insel PA, Wilderman A, Zhang L, Keshwani MM, Zambon AC. PMID: 25028794.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. PMID: 23110364; PMCID: PMC3503394.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. GPCR expression in tissues and cells: are the optimal receptors being used as drug targets? Br J Pharmacol. 2012 Mar; 165(6):1613-1616. Insel PA, Snead A, Murray F, Zhang L, Yokouchi H, Katakia T, Kwon O, Dimucci D, Wilderman A. PMID: 21488863; PMCID: PMC3372817.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    12. Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease. J Hum Genet. 2011 Sep; 56(9):676-81. Peiró AM, Tang CM, Murray F, Zhang L, Brown LM, Chou D, Rassenti L, Kipps TJ, Kipps TA, Insel PA. PMID: 21796143; PMCID: PMC3833258.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiol (Oxf). 2012 Feb; 204(2):277-87. Insel PA, Zhang L, Murray F, Yokouchi H, Zambon AC. PMID: 21385327; PMCID: PMC3125423.
      View in: PubMed   Mentions: 94     Fields:    Translation:Cells
    14. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cell Signal. 2011 Oct; 23(10):1611-6. Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel PA. PMID: 21620962; PMCID: PMC3148345.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia. Int J Cancer. 2011 Sep 01; 129(5):1162-9. Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel PA. PMID: 21120911; PMCID: PMC3111850.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19532-7. Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. PMID: 19033455; PMCID: PMC2614795.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    17. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem. 2008 Feb 15; 283(7):4304-13. Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. PMID: 18048352; PMCID: PMC3882191.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    18. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8561-6. Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA. PMID: 15939874; PMCID: PMC1150853.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    19. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem. 2004 May 14; 279(20):20858-65. Zhang L, Insel PA. PMID: 14996839.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    20. Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1642-7. Zhang L, Insel PA. PMID: 11600428.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
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