Sonya Neal

Title(s)Associate Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    The Discovery of Molecules and Mechanisms in ERAD Retrotranslocation Pathways
    NIH R35GM133565Aug 15, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Discovering the machinery and mechanism of ERAD-M retrotranslocation
    NIH F32GM111024May 1, 2014 - Apr 30, 2017
    Role: Principal Investigator
    Characterization of redox-mediated protein in mitochondria
    NIH F31GM087108Jan 1, 2009 - Dec 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Proteotoxic stress and the ubiquitin proteasome system. Semin Cell Dev Biol. 2024 03 15; 156:107-120. Kandel R, Jung J, Neal S. PMID: 37734998; PMCID: PMC10807858.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Juneteenth in STEMM and the barriers to equitable science. Cell. 2023 06 08; 186(12):2510-2517. Mays A, Byars-Winston A, Hinton A, Marshall AG, Kirabo A, August A, Marlin BJ, Riggs B, Tolbert B, Wanjalla C, Womack C, Evans CS, Barnes C, Starbird C, Williams C, Reynolds C, Taabazuing C, Cameron CE, Murray DD, Applewhite D, Morton DJ, Lee D, Williams DW, Lynch D, Brady D, Lynch E, Rutaganira FUN, Silva GM, Shuler H, Saboor IA, Davis J, Dzirasa K, Hammonds-Odie L, Reyes L, Sweetwyne MT, McReynolds MR, Johnson MDL, Smith NA, Pittman N, Ajijola OA, Smith Q, Robinson RAS, Lewis SC, Murray SA, Black S, Neal SE, Andrisse S, Townsend S, Damo SM, Griffith TN, Lambert WM, Clemons WM. PMID: 37295396.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    3. The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases. Cold Spring Harb Perspect Biol. 2023 02 01; 15(2). Bhaduri S, Scott NA, Neal SE. PMID: 35940905; PMCID: PMC9899648.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress. PLoS Biol. 2023 01; 21(1):e3001950. Kandel R, Jung J, Syau D, Kuo T, Songster L, Horn C, Chapman C, Aguayo A, Duttke S, Benner C, Neal SE. PMID: 36689475; PMCID: PMC9894555.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis. EMBO J. 2023 02 15; 42(4):e112275. Bhaduri S, Aguayo A, Ohno Y, Proietto M, Jung J, Wang I, Kandel R, Singh N, Ibrahim I, Fulzele A, Bennett EJ, Kihara A, Neal SE. PMID: 36350249; PMCID: PMC9929635.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Quality Control: Maintaining molecular order and preventing cellular chaos. Mol Cell. 2022 04 21; 82(8):1390-1397. Neal S, Ohtake F, Cuervo AM, Hegde RS, Jakob U, Lazarou M, Gilbert WV, Chen ZJ, Tooze SA, Haber JE, Walters KJ, Hartl FU. PMID: 35452608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates. Cell Rep. 2022 Mar 22; 38(12):110578. Nejatfard A, Wauer N, Bhaduri S, Conn A, Gourkanti S, Singh N, Kuo T, Kandel R, Amaro RE, Neal SE. PMID: 35320719.
      View in: PubMed   Mentions:    Fields:    
    8. Decoding Transcription Regulatory Mechanisms Associated with Coccidioides immitis Phase Transition Using Total RNA. mSystems. 2022 Feb 22; 7(1):e0140421. Duttke SH, Beyhan S, Singh R, Neal S, Viriyakosol S, Fierer J, Kirkland TN, Stajich JE, Benner C, Carlin AF. PMID: 35076277; PMCID: PMC8788335.
      View in: PubMed   Mentions: 7     Fields:    
    9. Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates. Cell Rep. 2021 10 19; 37(3):109840. Nejatfard A, Wauer N, Bhaduri S, Conn A, Gourkanti S, Singh N, Kuo T, Kandel R, Amaro RE, Neal SE. PMID: 34686332; PMCID: PMC8641752.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Assays for studying normal versus suppressive ERAD-associated retrotranslocation pathways in yeast. STAR Protoc. 2021 09 17; 2(3):100640. Bhaduri S, Neal SE. PMID: 34278330; PMCID: PMC8271171.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors. iScience. 2021 Mar 19; 24(3):102196. Sam PN, Calzada E, Acoba MG, Zhao T, Watanabe Y, Nejatfard A, Trinidad JC, Shutt TE, Neal SE, Claypool SM. PMID: 33718843; PMCID: PMC7921845.
      View in: PubMed   Mentions: 9  
    12. Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity. Mol Biol Cell. 2021 04 01; 32(7):521-537. Flagg MP, Wangeline MA, Holland SR, Duttke SH, Benner C, Neal S, Hampton RY. PMID: 33566711; PMCID: PMC8101470.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation. iScience. 2020 Aug 21; 23(9):101493. Neal S, Syau D, Nejatfard A, Nadeau S, Hampton RY. PMID: 32891886; PMCID: PMC7481253.
      View in: PubMed   Mentions: 11  
    14. The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications. Biochim Biophys Acta Mol Cell Res. 2020 10; 1867(10):118793. Kandel RR, Neal SE. PMID: 32645330; PMCID: PMC7434706.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Assays for protein retrotranslocation in ERAD. Methods Enzymol. 2019; 619:1-26. Neal S, Duttke SH, Hampton RY. PMID: 30910017; PMCID: PMC10802991.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    16. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell. 2018 03 01; 69(5):915. Neal S, Jaeger PA, Duttke SH, Benner C, Glass CK, Ideker T, Hampton RY. PMID: 29499140.
      View in: PubMed   Mentions: 11     Fields:    
    17. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell. 2018 01 18; 69(2):306-320.e4. Neal S, Jaeger PA, Duttke SH, Benner C, K Glass C, Ideker T, Hampton RY. PMID: 29351849; PMCID: PMC6049073.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    18. Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space. Mol Biol Cell. 2017 Oct 15; 28(21):2773-2785. Neal SE, Dabir DV, Wijaya J, Boon C, Koehler CM. PMID: 28814504; PMCID: PMC5638582.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. J Biol Chem. 2017 02 24; 292(8):3112-3128. Neal S, Mak R, Bennett EJ, Hampton R. PMID: 28077573; PMCID: PMC5336148.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    20. Direct and essential function for Hrd3 in ER-associated degradation. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):5934-9. Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY. PMID: 27170191; PMCID: PMC4889393.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    21. Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway. J Biol Chem. 2015 Aug 21; 290(34):20804-20814. Neal SE, Dabir DV, Tienson HL, Horn DM, Glaeser K, Ogozalek Loo RR, Barrientos A, Koehler CM. PMID: 26085103; PMCID: PMC4543643.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. Mol Biol Cell. 2009 Aug; 20(15):3481-90. Tienson HL, Dabir DV, Neal SE, Loo R, Hasson SA, Boontheung P, Kim SK, Loo JA, Koehler CM. PMID: 19477928; PMCID: PMC2719566.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells