Jonathan Pokorski

Title(s)Associate Professor, Nanoengineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    mRNA COVID-19 Vaccines Delivered with Plant Virus/Polymer Devices
    NIH R21AI161306Apr 1, 2021 - Mar 31, 2023
    Role: Co-Principal Investigator
    Protein/Polymer Devices for Slow-Release of Immunotherapies to Treat Ovarian Cancer
    NIH R21EB024874Sep 5, 2017 - Jun 30, 2020
    Role: Principal Investigator
    Development of Protein-Displaying Peptide Hydrogels for Tissue Engineering
    NIH R00EB011530Feb 15, 2012 - Jan 31, 2015
    Role: Principal Investigator
    Development of Protein-Displaying Peptide Hydrogels for Tissue Engineering
    NIH K99EB011530Apr 1, 2010 - Mar 31, 2012
    Role: Principal Investigator
    Molecular Evoluation of Virus based Hydrogels for Cancer Therapy
    NIH F32CA130318Sep 15, 2007 - Mar 31, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Trivalent Subunit Vaccine Candidates for COVID-19 and Their Delivery Devices. J Am Chem Soc. 2021 Sep 07. Ortega-Rivera OA, Shin MD, Chen A, Beiss V, Moreno-Gonzalez MA, Lopez-Ramirez MA, Reynoso M, Wang H, Hurst BL, Wang J, Pokorski JK, Steinmetz NF. PMID: 34490778.
      View in: PubMed   Mentions:
    2. Tobacco mosaic virus for the targeted delivery of drugs to cells expressing prostate-specific membrane antigen. RSC Adv. 2021 Jun 06; 11(33):20101-20108. Shukla S, Marks I, Church D, Chan SK, Pokorski JK, Steinmetz NF. PMID: 34178308.
      View in: PubMed   Mentions:
    3. Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss. Macromol Biosci. 2021 Jul; 21(7):e2000328. Lu CY, Church DC, Learn GD, Pokorski JK, von Recum HA. PMID: 33885231.
      View in: PubMed   Mentions:    Fields:    
    4. Hot melt extrusion: An emerging manufacturing method for slow and sustained protein delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 09; 13(5):e1712. Zheng Y, Pokorski JK. PMID: 33691347.
      View in: PubMed   Mentions:    Fields:    
    5. COVID-19 vaccine development and a potential nanomaterial path forward. Nat Nanotechnol. 2020 08; 15(8):646-655. Shin MD, Shukla S, Chung YH, Beiss V, Chan SK, Ortega-Rivera OA, Wirth DM, Chen A, Sack M, Pokorski JK, Steinmetz NF. PMID: 32669664.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCellsPHPublic Health
    6. Optimization of Ring-Opening Metathesis Polymerization (ROMP) under Physiologically Relevant Conditions. Polym Chem. 2020 Jul 21; 11(27):4492-4499. Church DC, Takiguchi L, Pokorski JK. PMID: 33796158.
      View in: PubMed   Mentions:
    7. Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers. Angew Chem Int Ed Engl. 2020 07 06; 59(28):11379-11383. Church DC, Pokorski JK. PMID: 32281276.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Highly Expandable Foam for Lithographic 3D Printing. ACS Appl Mater Interfaces. 2020 Apr 22; 12(16):19033-19043. Wirth DM, Jaquez A, Gandarilla S, Hochberg JD, Church DC, Pokorski JK. PMID: 32267677.
      View in: PubMed   Mentions: 2     Fields:    
    9. Built-In Active Microneedle Patch with Enhanced Autonomous Drug Delivery. Adv Mater. 2020 Jan; 32(1):e1905740. Lopez-Ramirez MA, Soto F, Wang C, Rueda R, Shukla S, Silva-Lopez C, Kupor D, McBride DA, Pokorski JK, Nourhani A, Steinmetz NF, Shah NJ, Wang J. PMID: 31682039.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    10. Freeze-Drying To Produce Efficacious CPMV Virus-like Particles. . 2019 03 13; 19(3):2099-2105. Zheng Y, Lee PW, Wang C, Thomas LD, Stewart PL, Steinmetz NF, Pokorski JK. PMID: 30801195.
      View in: PubMed   Mentions:
    11. Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles. Vaccine. 2018 10 08; 36(42):6345-6353. Purwar M, Pokorski JK, Singh P, Bhattacharyya S, Arendt H, DeStefano J, La Branche CC, Montefiori DC, Finn MG, Varadarajan R. PMID: 30220462.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. "Click" Chemistry for Medicine and Biology. Mol Pharm. 2018 08 06; 15(8):2891. Pokorski JK, Smith LE. PMID: 30078333.
      View in: PubMed   Mentions:    Fields:    
    13. Polymeric Interventions for Microbial Infections: A Review. Mol Pharm. 2018 08 06; 15(8):2910-2921. Hutnick MA, Pokorski JK. PMID: 29787274.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Poly(lactic-co-glycolic acid) devices: Production and applications for sustained protein delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Sep; 10(5):e1516. Lee PW, Pokorski JK. PMID: 29536634.
      View in: PubMed   Mentions: 5     Fields:    
    15. Slow-Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer. Adv Sci (Weinh). 2018 May; 5(5):1700991. Czapar AE, Tiu BDB, Veliz FA, Pokorski JK, Steinmetz NF. PMID: 29876220.
      View in: PubMed   Mentions:
    16. pH Responsive Doxorubicin Delivery by Fluorous Polymers for Cancer Treatment. Mol Pharm. 2018 08 06; 15(8):2954-2962. Wallat JD, Harrison JK, Pokorski JK. PMID: 29381366.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Milling solid proteins to enhance activity after melt-encapsulation. Int J Pharm. 2017 Nov 25; 533(1):254-265. Lee PW, Maia J, Pokorski JK. PMID: 28939464.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing. ACS Nano. 2017 09 26; 11(9):8777-8789. Lee PW, Shukla S, Wallat JD, Danda C, Steinmetz NF, Maia J, Pokorski JK. PMID: 28902491.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    19. In Situ Fabrication of Fiber Reinforced Three-Dimensional Hydrogel Tissue Engineering Scaffolds. ACS Biomater Sci Eng. 2017 Aug 14; 3(8):1869-1879. Jordan AM, Kim SE, Van de Voorde K, Pokorski JK, Korley LTJ. PMID: 33429666.
      View in: PubMed   Mentions:
    20. Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo. Anal Chem. 2017 06 06; 89(11):5932-5939. Johansen ML, Gao Y, Hutnick MA, Craig SEL, Pokorski JK, Flask CA, Brady-Kalnay SM. PMID: 28481080.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    21. Biologically Triggered Delivery of EGF from Polymer Fiber Patches. ACS Macro Lett. 2017; 6(6):593-597. Kim SE, Lee PW, Pokorski JK. PMID: 29250460.
      View in: PubMed   Mentions:
    22. Erythromycin Modification That Improves Its Acidic Stability while Optimizing It for Local Drug Delivery. Antibiotics (Basel). 2017 Apr 25; 6(2). Cyphert EL, Wallat JD, Pokorski JK, von Recum HA. PMID: 28441360.
      View in: PubMed   Mentions:
    23. Drawing in poly(e-caprolactone) fibers: tuning mechanics, fiber dimensions and surface-modification density. J Mater Chem B. 2017 Jun 21; 5(23):4499-4506. Kim SE, Jordan AM, Korley LTJ, Pokorski JK. PMID: 32263976.
      View in: PubMed   Mentions:    Fields:    
    24. Electrostatic layer-by-layer construction of fibrous TMV biofilms. Nanoscale. 2017 Jan 26; 9(4):1580-1590. Tiu BD, Kernan DL, Tiu SB, Wen AM, Zheng Y, Pokorski JK, Advincula RC, Steinmetz NF. PMID: 28070572.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle-Polymer Conjugates. J Am Chem Soc. 2017 03 08; 139(9):3312-3315. Lee PW, Isarov SA, Wallat JD, Molugu SK, Shukla S, Sun JE, Zhang J, Zheng Y, Lucius Dougherty M, Konkolewicz D, Stewart PL, Steinmetz NF, Hore MJ, Pokorski JK. PMID: 28121424.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. PEGylated Dendrimers as Drug Delivery Vehicles for the Photosensitizer Silicon Phthalocyanine Pc 4 for Candidal Infections. Biomacromolecules. 2017 02 13; 18(2):379-385. Hutnick MA, Ahsanuddin S, Guan L, Lam M, Baron ED, Pokorski JK. PMID: 28117573.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    27. 3D Printing Biocompatible Polyurethane/Poly(lactic acid)/Graphene Oxide Nanocomposites: Anisotropic Properties. ACS Appl Mater Interfaces. 2017 Feb 01; 9(4):4015-4023. Chen Q, Mangadlao JD, Wallat J, De Leon A, Pokorski JK, Advincula RC. PMID: 28026926.
      View in: PubMed   Mentions: 31     Fields:    
    28. Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles. Biomacromolecules. 2017 01 09; 18(1):103-112. Wallat JD, Czapar AE, Wang C, Wen AM, Wek KS, Yu X, Steinmetz NF, Pokorski JK. PMID: 27992176.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Processing and surface modification of polymer nanofibers for biological scaffolds: a review. J Mater Chem B. 2016 Sep 28; 4(36):5958-5974. Jordan AM, Viswanath V, Kim SE, Pokorski JK, Korley LTJ. PMID: 32263485.
      View in: PubMed   Mentions: 3     Fields:    
    30. Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio. J Phys Chem B. 2016 07 07; 120(26):6120-9. Chariou PL, Lee KL, Pokorski JK, Saidel GM, Steinmetz NF. PMID: 27045770.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    31. Protein and Bacterial Antifouling Behavior of Melt-Coextruded Nanofiber Mats. ACS Appl Mater Interfaces. 2016 Apr 13; 8(14):8928-38. Kim SE, Zhang C, Advincula AA, Baer E, Pokorski JK. PMID: 27043205.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. "Graft-to" Protein/Polymer Conjugates Using Polynorbornene Block Copolymers. Biomacromolecules. 2016 Feb 08; 17(2):641-8. Isarov SA, Lee PW, Pokorski JK. PMID: 26765848.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. PEGylation to Improve Protein Stability During Melt Processing. Macromol Biosci. 2015 Oct; 15(10):1332-7. Lee P, Towslee J, Maia J, Pokorski J. PMID: 26097064.
      View in: PubMed   Mentions: 5     Fields:    
    34. Multifunctional and Spatially Controlled Bioconjugation to Melt Coextruded Nanofibers. Polym Chem. 2015 Aug 21; 6(31):5683-5692. Kim SE, Wallat JD, Harker EC, Advincula AA, Pokorski JK. PMID: 26604990.
      View in: PubMed   Mentions:
    35. Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X. Acta Biomater. 2015 Jun; 19:166-79. Lee KL, Shukla S, Wu M, Ayat NR, El Sanadi CE, Wen AM, Edelbrock JF, Pokorski JK, Commandeur U, Dubyak GR, Steinmetz NF. PMID: 25769228.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    36. Coextruded, aligned, and gradient-modified poly(e-caprolactone) fibers as platforms for neural growth. Biomacromolecules. 2015 Mar 09; 16(3):860-7. Kim SE, Harker EC, De Leon AC, Advincula RC, Pokorski JK. PMID: 25715836.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Molecular Imaging of Tumors Using a Quantitative T 1 Mapping Technique via Magnetic Resonance Imaging. Diagnostics (Basel). 2015; 5(3):318-32. Herrmann K, Johansen ML, Craig SE, Vincent J, Howell M, Gao Y, Lu L, Erokwu B, Agnes RS, Lu ZR, Pokorski JK, Basilion J, Gulani V, Griswold M, Flask C, Brady-Kalnay SM. PMID: 26435847.
      View in: PubMed   Mentions:
    38. Surface Modification of Melt Extruded Poly(e-caprolactone) Nanofibers: Toward a New Scalable Biomaterial Scaffold. ACS Macro Lett. 2014 Jun 17; 3(6):585-589. Kim SE, Wang J, Jordan AM, Korley LT, Baer E, Pokorski JK. PMID: 24977107.
      View in: PubMed   Mentions:
    39. Peptide and protein-based inhibitors of HIV-1 co-receptors. Exp Biol Med (Maywood). 2013 May; 238(5):442-9. von Recum HA, Pokorski JK. PMID: 23856897.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    40. Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA. J Nucleic Acids. 2012; 2012:971581. Pokorski JK, Appella DH. PMID: 22957210.
      View in: PubMed   Mentions:
    41. Photodynamic activity of viral nanoparticles conjugated with C60. Chem Commun (Camb). 2012 Sep 18; 48(72):9044-6. Wen AM, Ryan MJ, Yang AC, Breitenkamp K, Pokorski JK, Steinmetz NF. PMID: 22858632.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    42. Bio-inspired synthesis and biological evaluation of a colchicine-related compound library. Bioorg Med Chem Lett. 2012 Jun 01; 22(11):3776-80. Nicolaou KC, Valiulin RA, Pokorski JK, Chang V, Chen JS. PMID: 22542017.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    43. Cell targeting with hybrid Qß virus-like particles displaying epidermal growth factor. Chembiochem. 2011 Nov 04; 12(16):2441-7. Pokorski JK, Hovlid ML, Finn MG. PMID: 21956837.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    44. Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization. J Am Chem Soc. 2011 Jun 22; 133(24):9242-5. Pokorski JK, Breitenkamp K, Liepold LO, Qazi S, Finn MG. PMID: 21627118.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    45. The art of engineering viral nanoparticles. Mol Pharm. 2011 Feb 07; 8(1):29-43. Pokorski JK, Steinmetz NF. PMID: 21047140.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    46. Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution. Org Lett. 2007 Jun 07; 9(12):2381-3. Pokorski JK, Jenkins LM, Feng H, Durell SR, Bai Y, Appella DH. PMID: 17506576.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    47. Peptide nucleic acid microarrays made with (S,S)-trans-cyclopentane-constrained peptide nucleic acids. Methods Enzymol. 2006; 410:189-200. Witschi MA, Pokorski JK, Appella DH. PMID: 16938552.
      View in: PubMed   Mentions:    Fields:    
    48. Enhanced oligonucleotide binding to self-assembled nanofibers. Bioconjug Chem. 2005 May-Jun; 16(3):501-3. Guler MO, Pokorski JK, Appella DH, Stupp SI. PMID: 15898715.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    49. Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection. Chem Commun (Camb). 2005 Apr 28; (16):2101-3. Pokorski JK, Nam JM, Vega RA, Mirkin CA, Appella DH. PMID: 15846413.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    50. Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity. Org Lett. 2004 Dec 09; 6(25):4699-702. Myers MC, Pokorski JK, Appella DH. PMID: 15575664.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    51. (S,S)-trans-cyclopentane-constrained peptide nucleic acids. a general backbone modification that improves binding affinity and sequence specificity. J Am Chem Soc. 2004 Nov 24; 126(46):15067-73. Pokorski JK, Witschi MA, Purnell BL, Appella DH. PMID: 15548003.
      View in: PubMed   Mentions: 18     Fields:    
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