Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Stanley Opella

    TitleResearcher
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0307
    CA La Jolla 92093
    Phone858-822-4820
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Structures, Dynamics, and Functions of Membrane Proteins
      NIH/NIGMS R35GM122501May 1, 2017 - Apr 30, 2022
      Role: Principal Investigator
      Structure Determination of Membrane Proteins in Phospholipid Bilyaers
      NIH/NIGMS R01GM099986Apr 1, 2012 - Mar 31, 2016
      Role: Principal Investigator
      Protein-Protein Interaction in Natural Product Biosynthesis
      NIH/NIGMS R01GM095970Mar 1, 2012 - Jan 31, 2020
      Role: Principal Investigator
      Acquisition of a Cryoprobe for an 800 MHz NMR Spectrometer
      NIH/NCRR S10RR023773Mar 1, 2008 - Feb 28, 2009
      Role: Principal Investigator
      Membrane Protein Structures in Phospholipid Bilayers by Solid State NMR
      NIH/NIGMS R01GM075877Sep 23, 2005 - Jul 31, 2011
      Role: Principal Investigator
      Molecular Imaging of G-Protein-Coupled Receptors for Drug Development
      NIH/NIBIB R01EB005161Apr 1, 2005 - Apr 30, 2015
      Role: Principal Investigator
      Structure, Dynamics, and Functions of the Viroporins Vpu from HIV and p7 from HCV
      NIH/NIGMS R01GM066978Jul 1, 2003 - Jul 31, 2017
      Role: Principal Investigator
      CONFERENCE ON FRONTIERS OF NMR IN MOLECULAR BIOLOGY VII
      NIH/NCI R13CA088925Mar 5, 2001 - Feb 28, 2002
      Role: Principal Investigator
      PHAGE DISPLAY--STRUCTURE, BIOLOGY AND APPLICATIONS
      NIH/NCI R13CA090984Sep 1, 2000 - Dec 31, 2003
      Role: Principal Investigator
      CONFERENCE ON FRONTIERS OF NMR IN MOLECULAR BIOLOGY
      NIH/NIDDK R13DK054982Jan 1, 1999 - Dec 31, 1999
      Role: Principal Investigator
      NMR PROBES FOR MEMBRANE PROTEIN STRUCTURE DETERMINATION
      NIH/NCRR R01RR012599Aug 1, 1998 - Mar 31, 2003
      Role: Principal Investigator
      STRUCTURAL BIOLOGY OF AIDS RELATED PROJECTS
      NIH/NIGMS P01GM056538Aug 1, 1997 - Nov 30, 2003
      Role: Principal Investigator
      Resource for NMR Molecular Imaging of Proteins
      NIH/NIBIB P41EB002031Apr 10, 1994 - May 31, 2019
      Role: Principal Investigator
      RESOURCE FOR SOLID STATE NMR OF PROTEINS
      NIH/NCRR P41RR009793Apr 10, 1994 - May 30, 2004
      Role: Principal Investigator
      PROTEIN STRUCTURE BY SOLID-STATE NMR SPECTROSCOPY
      NIH/NCRR R24RR005976Apr 1, 1991 - Mar 31, 1994
      Role: Principal Investigator
      NMR STRUCTURAL STUDIES OF MEMBRANE PROTEINS
      NIH/NIAID R01AI020770Dec 1, 1984 - Jun 30, 1998
      Role: Principal Investigator
      SOLID STATE NMR OF PEPTIDES
      NIH/NIBIB R01EB002169Jan 1, 1982 - Mar 31, 2006
      Role: Principal Investigator
      SOLID STATE NMR OF PEPTIDES
      NIH/NIGMS R01GM029754Jan 1, 1982 - Mar 31, 2005
      Role: Principal Investigator
      Consolidated Basic Cancer Research Program
      NIH P30CA010815Sep 1, 1978 - Feb 28, 2019
      Role: Co-Investigator
      NMR Studies of Biological Supramolecular Structures
      NIH/NIBIB R01EB001966Aug 1, 1977 - Feb 28, 2009
      Role: Principal Investigator
      NMR STUDIES OF BIOLOGICAL SUPRAMOLECULAR STRUCTURES
      NIH/NIGMS R37GM024266Aug 1, 1977 - Mar 31, 2004
      Role: Principal Investigator
      NMR STUDIES OF BIOLOGICAL SUPRAMOLECULAR STRUCTURES
      NIH/NIGMS R01GM024266Aug 1, 1977 - Jul 31, 1993
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Jaremko MJ, Lee DJ, Patel A, Winslow V, Opella S, McCammon JA, Burkart MD. Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins. Biochemistry. 2017 Oct 02. PMID: 28920687.
        View in: PubMed
      2. Amin A, Latif Z, Opella S. Expression and Purification of Transmembrane Protein MerE from Mercury Resistant Bacillus cereus. J Microbiol Biotechnol. 2017 Aug 08. PMID: 28783894.
        View in: PubMed
      3. Opella S, Marassi FM. Applications of NMR to membrane proteins. Arch Biochem Biophys. 2017 Aug 15; 628:92-101. PMID: 28529197.
        View in: PubMed
      4. Yao Y, Dutta SK, Park SH, Rai R, Fujimoto LM, Bobkov AA, Opella S, Marassi FM. High resolution solid-state NMR spectroscopy of the Yersinia pestis outer membrane protein Ail in lipid membranes. J Biomol NMR. 2017 Mar; 67(3):179-190. PMID: 28239773.
        View in: PubMed
      5. Tian Y, Schwieters CD, Opella S, Marassi FM. High quality NMR structures: a new force field with implicit water and membrane solvation for Xplor-NIH. J Biomol NMR. 2017 Jan; 67(1):35-49. PMID: 28035651.
        View in: PubMed
      6. Das BB, Opella S. Simultaneous cross polarization to (13)C and (15)N with (1)H detection at 60kHz MAS solid-state NMR. J Magn Reson. 2016 Jan; 262:20-26. PMID: 26705905; PMCID: PMC4716881 [Available on 01/01/17].
      7. Zhang H, Lin EC, Das BB, Tian Y, Opella S. Structural determination of virus protein U from HIV-1 by NMR in membrane environments. Biochim Biophys Acta. 2015 Nov; 1848(11 Pt A):3007-3018. PMID: 26362058; PMCID: PMC4623708 [Available on 11/01/16].
      8. Jaremko MJ, Lee DJ, Opella S, Burkart MD. Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL. J Am Chem Soc. 2015 Sep 16; 137(36):11546-9. PMID: 26340431; PMCID: PMC4847951.
      9. Tian Y, Schwieters CD, Opella S, Marassi FM. A Practical Implicit Membrane Potential for NMR Structure Calculations of Membrane Proteins. Biophys J. 2015 Aug 04; 109(3):574-85. PMID: 26244739; PMCID: PMC4572468.
      10. Opella S. Relating structure and function of viral membrane-spanning miniproteins. Curr Opin Virol. 2015 Jun; 12:121-5. PMID: 26057606; PMCID: PMC4476644.
      11. Lewinski MK, Jafari M, Zhang H, Opella S, Guatelli J. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly. J Biol Chem. 2015 Apr 24; 290(17):10919-33. PMID: 25759385; PMCID: PMC4409254.
      12. Opella S. Solid-state NMR and membrane proteins. J Magn Reson. 2015 Apr; 253:129-37. PMID: 25681966; PMCID: PMC4372479.
      13. Park SH, Wang VS, Radoicic J, De Angelis AA, Berkamp S, Opella S. Paramagnetic relaxation enhancement of membrane proteins by incorporation of the metal-chelating unnatural amino acid 2-amino-3-(8-hydroxyquinolin-3-yl)propanoic acid (HQA). J Biomol NMR. 2015 Apr; 61(3-4):185-96. PMID: 25430059; PMCID: PMC4398598.
      14. Tian Y, Lu GJ, Marassi FM, Opella S. Structure of the membrane protein MerF, a bacterial mercury transporter, improved by the inclusion of chemical shift anisotropy constraints. J Biomol NMR. 2014 Sep; 60(1):67-71. PMID: 25103921; PMCID: PMC4154067.
      15. Radoicic J, Lu GJ, Opella S. NMR structures of membrane proteins in phospholipid bilayers. Q Rev Biophys. 2014 Aug; 47(3):249-83. PMID: 25032938; PMCID: PMC4153756.
      16. Wu CH, De Angelis AA, Opella S. Magic angle Lee-Goldburg frequency offset irradiation improves the efficiency and selectivity of SPECIFIC-CP in triple-resonance MAS solid-state NMR. J Magn Reson. 2014 Sep; 246:1-3. PMID: 25051542; PMCID: PMC4165850.
      17. Das BB, Opella S. Multiple acquisition/multiple observation separated local field/chemical shift correlation solid-state magic angle spinning NMR spectroscopy. J Magn Reson. 2014 Aug; 245:98-104. PMID: 25023566; PMCID: PMC4128693.
      18. Das BB, Park SH, Opella S. Membrane protein structure from rotational diffusion. Biochim Biophys Acta. 2015 Jan; 1848(1 Pt B):229-45. PMID: 24747039; PMCID: PMC4201901.
      19. Tian Y, Schwieters CD, Opella S, Marassi FM. A practical implicit solvent potential for NMR structure calculation. J Magn Reson. 2014 Jun; 243:54-64. PMID: 24747742; PMCID: PMC4037354.
      20. Lu GJ, Opella S. Mechanism of dilute-spin-exchange in solid-state NMR. J Chem Phys. 2014 Mar 28; 140(12):124201. PMID: 24697432; PMCID: PMC3971823.
      21. Das BB, Zhang H, Opella S. Dipolar Assisted Assignment Protocol (DAAP) for MAS solid-state NMR of rotationally aligned membrane proteins in phospholipid bilayers. J Magn Reson. 2014 May; 242:224-32. PMID: 24698983; PMCID: PMC4043445.
      22. Perrin BS, Tian Y, Fu R, Grant CV, Chekmenev EY, Wieczorek WE, Dao AE, Hayden RM, Burzynski CM, Venable RM, Sharma M, Opella S, Pastor RW, Cotten ML. High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion. J Am Chem Soc. 2014 Mar 05; 136(9):3491-504. PMID: 24410116; PMCID: PMC3985945.
      23. Opella S. The development of solid-state NMR of membrane proteins. Biomed Spectrosc Imaging. 2014; 3(2):81-105. PMID: 26069880.
        View in: PubMed
      24. Nguyen C, Haushalter RW, Lee DJ, Markwick PR, Bruegger J, Caldara-Festin G, Finzel K, Jackson DR, Ishikawa F, O'Dowd B, McCammon JA, Opella S, Tsai SC, Burkart MD. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 2014 Jan 16; 505(7483):427-31. PMID: 24362570; PMCID: PMC4437705.
      25. Lu GJ, Opella S. Resonance assignments of a membrane protein in phospholipid bilayers by combining multiple strategies of oriented sample solid-state NMR. J Biomol NMR. 2014 Jan; 58(1):69-81. PMID: 24356892; PMCID: PMC3928288.
      26. Lin EC, Opella S. Covariance spectroscopy in high-resolution multi-dimensional solid-state NMR. J Magn Reson. 2014 Feb; 239:57-60. PMID: 24380813; PMCID: PMC3929046.
      27. Gleason NJ, Greathouse DV, Grant CV, Opella S, Koeppe RE. Single tryptophan and tyrosine comparisons in the N-terminal and C-terminal interface regions of transmembrane GWALP peptides. J Phys Chem B. 2013 Nov 07; 117(44):13786-94. PMID: 24111589; PMCID: PMC3934079.
      28. Park SH, Yang C, Opella S, Mueller LJ. Resolution and measurement of heteronuclear dipolar couplings of a noncrystalline protein immobilized in a biological supramolecular assembly by proton-detected MAS solid-state NMR spectroscopy. J Magn Reson. 2013 Dec; 237:164-8. PMID: 24225529; PMCID: PMC3915937.
      29. Wang Y, Park SH, Tian Y, Opella S. Impact of histidine residues on the transmembrane helices of viroporins. Mol Membr Biol. 2013 Nov; 30(7):360-9. PMID: 24102567; PMCID: PMC4028331.
      30. Das BB, Lin EC, Opella S. Experiments optimized for magic angle spinning and oriented sample solid-state NMR of proteins. J Phys Chem B. 2013 Oct 17; 117(41):12422-31. PMID: 24044695; PMCID: PMC3846429.
      31. Lin EC, Opella S. Sampling scheme and compressed sensing applied to solid-state NMR spectroscopy. J Magn Reson. 2013 Dec; 237:40-8. PMID: 24140622; PMCID: PMC3851314.
      32. Lu GJ, Opella S. Motion-adapted pulse sequences for oriented sample (OS) solid-state NMR of biopolymers. J Chem Phys. 2013 Aug 28; 139(8):084203. PMID: 24006989; PMCID: PMC3772948.
      33. Cook GA, Dawson LA, Tian Y, Opella S. Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance. Biochemistry. 2013 Aug 06; 52(31):5295-303. PMID: 23841474; PMCID: PMC3855088.
      34. Opella S. Structure determination of membrane proteins in their native phospholipid bilayer environment by rotationally aligned solid-state NMR spectroscopy. Acc Chem Res. 2013 Sep 17; 46(9):2145-53. PMID: 23829871; PMCID: PMC3778126.
      35. Lu GJ, Tian Y, Vora N, Marassi FM, Opella S. The structure of the mercury transporter MerF in phospholipid bilayers: a large conformational rearrangement results from N-terminal truncation. J Am Chem Soc. 2013 Jun 26; 135(25):9299-302. PMID: 23763519; PMCID: PMC3763827.
      36. Opella S. Structure determination of membrane proteins by nuclear magnetic resonance spectroscopy. Annu Rev Anal Chem (Palo Alto Calif). 2013; 6:305-28. PMID: 23577669; PMCID: PMC3980955.
      37. Yao Y, Ding Y, Tian Y, Opella S, Marassi FM. Membrane protein structure determination: back to the membrane. Methods Mol Biol. 2013; 1063:145-58. PMID: 23975776; PMCID: PMC4012560.
      38. Rankenberg JM, Vostrikov VV, Greathouse DV, Grant CV, Opella S, Koeppe RE. Properties of membrane-incorporated WALP peptides that are anchored on only one end. Biochemistry. 2012 Dec 18; 51(50):10066-74. PMID: 23171005; PMCID: PMC3527101.
      39. Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella S. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature. 2012 Nov 29; 491(7426):779-83. PMID: 23086146; PMCID: PMC3700570.
      40. Tian Y, Opella S, Marassi FM. Improved chemical shift prediction by Rosetta conformational sampling. J Biomol NMR. 2012 Nov; 54(3):237-43. PMID: 23007199; PMCID: PMC3484222.
      41. Lu GJ, Park SH, Opella S. Improved 1H amide resonance line narrowing in oriented sample solid-state NMR of membrane proteins in phospholipid bilayers. J Magn Reson. 2012 Jul; 220:54-61. PMID: 22683581; PMCID: PMC3760517.
      42. Rankenberg JM, Vostrikov VV, DuVall CD, Greathouse DV, Koeppe RE, Grant CV, Opella S. Proline kink angle distributions for GWALP23 in lipid bilayers of different thicknesses. Biochemistry. 2012 May 01; 51(17):3554-64. PMID: 22489564; PMCID: PMC3558528.
      43. Gleason NJ, Vostrikov VV, Greathouse DV, Grant CV, Opella S, Koeppe RE. Tyrosine replacing tryptophan as an anchor in GWALP peptides. Biochemistry. 2012 Mar 13; 51(10):2044-53. PMID: 22364236; PMCID: PMC3312603.
      44. Das BB, Nothnagel HJ, Lu GJ, Son WS, Tian Y, Marassi FM, Opella S. Structure determination of a membrane protein in proteoliposomes. J Am Chem Soc. 2012 Feb 01; 134(4):2047-56. PMID: 22217388; PMCID: PMC3272072.
      45. Vostrikov VV, Grant CV, Opella S, Koeppe RE. On the combined analysis of ²H and ¹5N/¹H solid-state NMR data for determination of transmembrane peptide orientation and dynamics. Biophys J. 2011 Dec 21; 101(12):2939-47. PMID: 22208192; PMCID: PMC3244059.
      46. Skasko M, Wang Y, Tian Y, Tokarev A, Munguia J, Ruiz A, Stephens EB, Opella S, Guatelli J. HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions. J Biol Chem. 2012 Jan 02; 287(1):58-67. PMID: 22072710; PMCID: PMC3249111.
      47. Son WS, Park SH, Nothnagel HJ, Lu GJ, Wang Y, Zhang H, Cook GA, Howell SC, Opella S. 'q-Titration' of long-chain and short-chain lipids differentiates between structured and mobile residues of membrane proteins studied in bicelles by solution NMR spectroscopy. J Magn Reson. 2012 Jan; 214(1):111-8. PMID: 22079194; PMCID: PMC3257358.
      48. Park SH, Casagrande F, Chu M, Maier K, Kiefer H, Opella S. Optimization of purification and refolding of the human chemokine receptor CXCR1 improves the stability of proteoliposomes for structure determination. Biochim Biophys Acta. 2012 Mar; 1818(3):584-91. PMID: 22024025; PMCID: PMC3777732.
      49. Park SH, Casagrande F, Cho L, Albrecht L, Opella S. Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy. J Mol Biol. 2011 Nov 25; 414(2):194-203. PMID: 22019593; PMCID: PMC3236022.
      50. Tian Y, Schwieters CD, Opella S, Marassi FM. AssignFit: a program for simultaneous assignment and structure refinement from solid-state NMR spectra. J Magn Reson. 2012 Jan; 214(1):42-50. PMID: 22036904; PMCID: PMC3257385.
      51. Park SH, Berkamp S, Cook GA, Chan MK, Viadiu H, Opella S. Nanodiscs versus macrodiscs for NMR of membrane proteins. Biochemistry. 2011 Oct 25; 50(42):8983-5. PMID: 21936505; PMCID: PMC3236031.
      52. Marassi FM, Das BB, Lu GJ, Nothnagel HJ, Park SH, Son WS, Tian Y, Opella S. Structure determination of membrane proteins in five easy pieces. Methods. 2011 Dec; 55(4):363-9. PMID: 21964394; PMCID: PMC3264820.
      53. De Angelis AA, Grant CV, Baxter MK, McGavin JA, Opella S, Cotten ML. Amphipathic antimicrobial piscidin in magnetically aligned lipid bilayers. Biophys J. 2011 Sep 07; 101(5):1086-94. PMID: 21889445; PMCID: PMC3164131.
      54. Lin EC, Opella S. 1H assisted 13C/15N heteronuclear correlation spectroscopy in oriented sample solid-state NMR of single crystal and magnetically aligned samples. J Magn Reson. 2011 Jul; 211(1):37-44. PMID: 21543244; PMCID: PMC3236683.
      55. Park SH, Casagrande F, Das BB, Albrecht L, Chu M, Opella S. Local and global dynamics of the G protein-coupled receptor CXCR1. Biochemistry. 2011 Mar 29; 50(12):2371-80. PMID: 21323370; PMCID: PMC3236025.
      56. Haushalter RW, Filipp FV, Ko KS, Yu R, Opella S, Burkart MD. Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein. ACS Chem Biol. 2011 May 20; 6(5):413-8. PMID: 21268653; PMCID: PMC3092034.
      57. Lu GJ, Son WS, Opella S. A general assignment method for oriented sample (OS) solid-state NMR of proteins based on the correlation of resonances through heteronuclear dipolar couplings in samples aligned parallel and perpendicular to the magnetic field. J Magn Reson. 2011 Apr; 209(2):195-206. PMID: 21316275; PMCID: PMC3109902.
      58. Cook GA, Stefer S, Opella S. Expression and purification of the membrane protein p7 from hepatitis C virus. Biopolymers. 2011; 96(1):32-40. PMID: 20560141; PMCID: PMC2954269.
      59. Park SH, Das BB, De Angelis AA, Scrima M, Opella S. Mechanically, magnetically, and "rotationally aligned" membrane proteins in phospholipid bilayers give equivalent angular constraints for NMR structure determination. J Phys Chem B. 2010 Nov 11; 114(44):13995-4003. PMID: 20961141; PMCID: PMC3760507.
      60. Park SH, Opella S. Triton X-100 as the "short-chain lipid" improves the magnetic alignment and stability of membrane proteins in phosphatidylcholine bilayers for oriented-sample solid-state NMR spectroscopy. J Am Chem Soc. 2010 Sep 15; 132(36):12552-3. PMID: 20735058; PMCID: PMC2958821.
      61. Park SH, Marassi FM, Black D, Opella S. Structure and dynamics of the membrane-bound form of Pf1 coat protein: implications of structural rearrangement for virus assembly. Biophys J. 2010 Sep 08; 99(5):1465-74. PMID: 20816058; PMCID: PMC2931714.
      62. Opella S. Perspectives in magnetic resonance. J Magn Reson. 2010 Sep; 206(1):1. PMID: 20727502.
        View in: PubMed
      63. Cook GA, Zhang H, Park SH, Wang Y, Opella S. Comparative NMR studies demonstrate profound differences between two viroporins: p7 of HCV and Vpu of HIV-1. Biochim Biophys Acta. 2011 Feb; 1808(2):554-60. PMID: 20727848; PMCID: PMC3005007.
      64. Cook GA, Opella S. Secondary structure, dynamics, and architecture of the p7 membrane protein from hepatitis C virus by NMR spectroscopy. Biochim Biophys Acta. 2011 Jun; 1808(6):1448-53. PMID: 20727850; PMCID: PMC3046219.
      65. Shealy P, Simin M, Park SH, Opella S, Valafar H. Simultaneous structure and dynamics of a membrane protein using REDCRAFT: membrane-bound form of Pf1 coat protein. J Magn Reson. 2010 Nov; 207(1):8-16. PMID: 20829084; PMCID: PMC3970221.
      66. Lin EC, Wu CH, Yang Y, Grant CV, Opella S. 1H-13C separated local field spectroscopy of uniformly 13C labeled peptides and proteins. J Magn Reson. 2010 Sep; 206(1):105-11. PMID: 20637662; PMCID: PMC2926282.
      67. Knox RW, Lu GJ, Opella S, Nevzorov AA. A resonance assignment method for oriented-sample solid-state NMR of proteins. J Am Chem Soc. 2010 Jun 23; 132(24):8255-7. PMID: 20509649; PMCID: PMC2909040.
      68. Grant CV, Wu CH, Opella S. Probes for high field solid-state NMR of lossy biological samples. J Magn Reson. 2010 Jun; 204(2):180-8. PMID: 20435493; PMCID: PMC2887343.
      69. Cook GA, Opella S. NMR studies of membrane proteins. Methods Mol Biol. 2010; 637:263-75. PMID: 20419440; PMCID: PMC3760502.
      70. Wu CH, Das BB, Opella S. (1)H-(13)C Hetero-nuclear dipole-dipole couplings of methyl groups in stationary and magic angle spinning solid-state NMR experiments of peptides and proteins. J Magn Reson. 2010 Feb; 202(2):127-34. PMID: 19896874; PMCID: PMC2888030.
      71. Park SH, Son WS, Mukhopadhyay R, Valafar H, Opella S. Phage-induced alignment of membrane proteins enables the measurement and structural analysis of residual dipolar couplings with dipolar waves and lambda-maps. J Am Chem Soc. 2009 Oct 14; 131(40):14140-1. PMID: 19761238; PMCID: PMC2771775.
      72. Cook GA, Opella S. NMR studies of p7 protein from hepatitis C virus. Eur Biophys J. 2010 Jun; 39(7):1097-104. PMID: 19727701; PMCID: PMC2878448.
      73. Filipp FV, Sinha N, Jairam L, Bradley J, Opella S. Labeling strategies for 13C-detected aligned-sample solid-state NMR of proteins. J Magn Reson. 2009 Dec; 201(2):121-30. PMID: 19781966; PMCID: PMC2804798.
      74. Grant CV, Yang Y, Glibowicka M, Wu CH, Park SH, Deber CM, Opella S. A Modified Alderman-Grant Coil makes possible an efficient cross-coil probe for high field solid-state NMR of lossy biological samples. J Magn Reson. 2009 Nov; 201(1):87-92. PMID: 19733108; PMCID: PMC2800166.
      75. Wu CH, Grant CV, Cook GA, Park SH, Opella S. A strip-shield improves the efficiency of a solenoid coil in probes for high-field solid-state NMR of lossy biological samples. J Magn Reson. 2009 Sep; 200(1):74-80. PMID: 19559634; PMCID: PMC2741312.
      76. Opella S. Faster is better: improving the sensitivity of solid-state NMR. Nat Methods. 2009 Mar; 6(3):197-8. PMID: 19247292.
        View in: PubMed
      77. Diller A, Loudet C, Aussenac F, Raffard G, Fournier S, Laguerre M, Grélard A, Opella S, Marassi FM, Dufourc EJ. Bicelles: A natural 'molecular goniometer' for structural, dynamical and topological studies of molecules in membranes. Biochimie. 2009 Jun; 91(6):744-51. PMID: 19248817; PMCID: PMC2899883.
      78. Page RC, Lee S, Moore JD, Opella S, Cross TA. Backbone structure of a small helical integral membrane protein: A unique structural characterization. Protein Sci. 2009 Jan; 18(1):134-46. PMID: 19177358; PMCID: PMC2708045.
      79. Vostrikov VV, Grant CV, Daily AE, Opella S, Koeppe RE. Comparison of "Polarization inversion with spin exchange at magic angle" and "geometric analysis of labeled alanines" methods for transmembrane helix alignment. J Am Chem Soc. 2008 Sep 24; 130(38):12584-5. PMID: 18763771; PMCID: PMC2609751.
      80. Park SH, Loudet C, Marassi FM, Dufourc EJ, Opella S. Solid-state NMR spectroscopy of a membrane protein in biphenyl phospholipid bicelles with the bilayer normal parallel to the magnetic field. J Magn Reson. 2008 Jul; 193(1):133-8. PMID: 18492613; PMCID: PMC2562692.
      81. Wu CH, Opella S. Shiftless nuclear magnetic resonance spectroscopy. J Chem Phys. 2008 Feb 07; 128(5):052312. PMID: 18266429; PMCID: PMC3760504.
      82. Opella S, Zeri AC, Park SH. Structure, dynamics, and assembly of filamentous bacteriophages by nuclear magnetic resonance spectroscopy. Annu Rev Phys Chem. 2008; 59:635-57. PMID: 18393681.
        View in: PubMed
      83. Sinha N, Filipp FV, Jairam L, Park SH, Bradley J, Opella S. Tailoring 13C labeling for triple-resonance solid-state NMR experiments on aligned samples of proteins. Magn Reson Chem. 2007 Dec; 45 Suppl 1:S107-15. PMID: 18157808; PMCID: PMC5010364.
      84. Wu CH, Opella S. Proton-detected separated local field spectroscopy. J Magn Reson. 2008 Jan; 190(1):165-70. PMID: 17981481; PMCID: PMC3486921.
      85. Müller SD, De Angelis AA, Walther TH, Grage SL, Lange C, Opella S, Ulrich AS. Structural characterization of the pore forming protein TatAd of the twin-arginine translocase in membranes by solid-state 15N-NMR. Biochim Biophys Acta. 2007 Dec; 1768(12):3071-9. PMID: 17980349.
        View in: PubMed
      86. Lee S, Howell SB, Opella S. NMR and mutagenesis of human copper transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization. Biochim Biophys Acta. 2007 Dec; 1768(12):3127-34. PMID: 17959139; PMCID: PMC2275670.
      87. Park SH, Opella S. Conformational changes induced by a single amino acid substitution in the trans-membrane domain of Vpu: implications for HIV-1 susceptibility to channel blocking drugs. Protein Sci. 2007 Oct; 16(10):2205-15. PMID: 17766368; PMCID: PMC2204142.
      88. Grant CV, Sit SL, De Angelis AA, Khuong KS, Wu CH, Plesniak LA, Opella S. An efficient (1)H/(31)P double-resonance solid-state NMR probe that utilizes a scroll coil. J Magn Reson. 2007 Oct; 188(2):279-84. PMID: 17719813; PMCID: PMC2097957.
      89. Kim MJ, Park SH, Opella S, Marsilje TH, Michellys PY, Seidel HM, Tian SS. NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains. J Biol Chem. 2007 May 11; 282(19):14253-61. PMID: 17369254.
        View in: PubMed
      90. Sinha N, Grant CV, Park SH, Brown JM, Opella S. Triple resonance experiments for aligned sample solid-state NMR of (13)C and (15)N labeled proteins. J Magn Reson. 2007 May; 186(1):51-64. PMID: 17293139; PMCID: PMC3760591.
      91. Das BB, Ajithkumar TG, Sinha N, Opella S, Ramanathan KV. Cross- and axial-peak intensities in 2D-SLF experiments based on cross-polarization--the role of the initial density matrix. J Magn Reson. 2007 Apr; 185(2):308-17. PMID: 17280846.
        View in: PubMed
      92. Nevzorov AA, Park SH, Opella S. Three-dimensional experiment for solid-state NMR of aligned protein samples in high field magnets. J Biomol NMR. 2007 Feb; 37(2):113-6. PMID: 17216304.
        View in: PubMed
      93. De Angelis AA, Opella S. Bicelle samples for solid-state NMR of membrane proteins. Nat Protoc. 2007; 2(10):2332-8. PMID: 17947974.
        View in: PubMed
      94. Nevzorov AA, Opella S. Selective averaging for high-resolution solid-state NMR spectroscopy of aligned samples. J Magn Reson. 2007 Mar; 185(1):59-70. PMID: 17074522.
        View in: PubMed
      95. De Angelis AA, Howell SC, Opella S. Assigning solid-state NMR spectra of aligned proteins using isotropic chemical shifts. J Magn Reson. 2006 Dec; 183(2):329-32. PMID: 16997587.
        View in: PubMed
      96. De Angelis AA, Howell SC, Nevzorov AA, Opella S. Structure determination of a membrane protein with two trans-membrane helices in aligned phospholipid bicelles by solid-state NMR spectroscopy. J Am Chem Soc. 2006 Sep 20; 128(37):12256-67. PMID: 16967977; PMCID: PMC3236029.
      97. Park SH, De Angelis AA, Nevzorov AA, Wu CH, Opella S. Three-dimensional structure of the transmembrane domain of Vpu from HIV-1 in aligned phospholipid bicelles. Biophys J. 2006 Oct 15; 91(8):3032-42. PMID: 16861273; PMCID: PMC1578490.
      98. Page RC, Moore JD, Nguyen HB, Sharma M, Chase R, Gao FP, Mobley CK, Sanders CR, Ma L, Sönnichsen FD, Lee S, Howell SC, Opella S, Cross TA. Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins. J Struct Funct Genomics. 2006 Mar; 7(1):51-64. PMID: 16850177.
        View in: PubMed
      99. Park SH, Prytulla S, De Angelis AA, Brown JM, Kiefer H, Opella S. High-resolution NMR spectroscopy of a GPCR in aligned bicelles. J Am Chem Soc. 2006 Jun 14; 128(23):7402-3. PMID: 16756269; PMCID: PMC3236030.
      100. Opella S. Structural biology: designer labels. Nature. 2006 Mar 02; 440(7080):40. PMID: 16511484.
        View in: PubMed
      101. Smurnyy Y, Opella S. Calculating protein structures directly from anisotropic spin interaction constraints. Magn Reson Chem. 2006 Mar; 44(3):283-93. PMID: 16477675.
        View in: PubMed
      102. Jones DH, Opella S. Application of Maximum Entropy reconstruction to PISEMA spectra. J Magn Reson. 2006 Mar; 179(1):105-13. PMID: 16343957.
        View in: PubMed
      103. DeSilva TM, Veglia G, Opella S. Solution structures of the reduced and Cu(I) bound forms of the first metal binding sequence of ATP7A associated with Menkes disease. Proteins. 2005 Dec 01; 61(4):1038-49. PMID: 16211579.
        View in: PubMed
      104. Park SH, Mrse AA, Nevzorov AA, De Angelis AA, Opella S. Rotational diffusion of membrane proteins in aligned phospholipid bilayers by solid-state NMR spectroscopy. J Magn Reson. 2006 Jan; 178(1):162-5. PMID: 16213759.
        View in: PubMed
      105. Sinha N, Grant CV, Wu CH, De Angelis AA, Howell SC, Opella S. SPINAL modulated decoupling in high field double- and triple-resonance solid-state NMR experiments on stationary samples. J Magn Reson. 2005 Dec; 177(2):197-202. PMID: 16137902.
        View in: PubMed
      106. Park SH, Opella S. Tilt angle of a trans-membrane helix is determined by hydrophobic mismatch. J Mol Biol. 2005 Jul 08; 350(2):310-8. PMID: 15936031.
        View in: PubMed
      107. Sinha N, Grant CV, Rotondi KS, Feduik-Rotondi L, Gierasch LM, Opella S. Peptides and the development of double- and triple-resonance solid-state NMR of aligned samples. J Pept Res. 2005 Jun; 65(6):605-20. PMID: 15885119.
        View in: PubMed
      108. Howell SC, Mesleh MF, Opella S. NMR structure determination of a membrane protein with two transmembrane helices in micelles: MerF of the bacterial mercury detoxification system. Biochemistry. 2005 Apr 05; 44(13):5196-206. PMID: 15794657.
        View in: PubMed
      109. Zheng H, Zhao J, Wang S, Lin CM, Chen T, Jones DH, Ma C, Opella S, Xie XQ. Biosynthesis and purification of a hydrophobic peptide from transmembrane domains of G-protein-coupled CB2 receptor. J Pept Res. 2005 Apr; 65(4):450-8. PMID: 15813893.
        View in: PubMed
      110. Thiriot DS, Nevzorov AA, Opella S. Structural basis of the temperature transition of Pf1 bacteriophage. Protein Sci. 2005 Apr; 14(4):1064-70. PMID: 15741342; PMCID: PMC2253442.
      111. De Angelis AA, Jones DH, Grant CV, Park SH, Mesleh MF, Opella S. NMR experiments on aligned samples of membrane proteins. Methods Enzymol. 2005; 394:350-82. PMID: 15808228.
        View in: PubMed
      112. Jones DH, Opella S. Weak alignment of membrane proteins in stressed polyacrylamide gels. J Magn Reson. 2004 Dec; 171(2):258-69. PMID: 15546752.
        View in: PubMed
      113. De Angelis AA, Nevzorov AA, Park SH, Howell SC, Mrse AA, Opella S. High-resolution NMR spectroscopy of membrane proteins in aligned bicelles. J Am Chem Soc. 2004 Dec 01; 126(47):15340-1. PMID: 15563135.
        View in: PubMed
      114. Thiriot DS, Nevzorov AA, Zagyanskiy L, Wu CH, Opella S. Structure of the coat protein in Pf1 bacteriophage determined by solid-state NMR spectroscopy. J Mol Biol. 2004 Aug 13; 341(3):869-79. PMID: 15288792.
        View in: PubMed
      115. Opella S, Marassi FM. Structure determination of membrane proteins by NMR spectroscopy. Chem Rev. 2004 Aug; 104(8):3587-606. PMID: 15303829; PMCID: PMC3270942.
      116. Kochendoerfer GG, Jones DH, Lee S, Oblatt-Montal M, Opella S, Montal M. Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis. J Am Chem Soc. 2004 Mar 03; 126(8):2439-46. PMID: 14982452.
        View in: PubMed
      117. Nevzorov AA, Mesleh MF, Opella S. Structure determination of aligned samples of membrane proteins by NMR spectroscopy. Magn Reson Chem. 2004 Feb; 42(2):162-71. PMID: 14745796.
        View in: PubMed
      118. Park SH, Mrse AA, Nevzorov AA, Mesleh MF, Oblatt-Montal M, Montal M, Opella S. Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1. J Mol Biol. 2003 Oct 17; 333(2):409-24. PMID: 14529626.
        View in: PubMed
      119. Nevzorov AA, Opella S. A "magic sandwich" pulse sequence with reduced offset dependence for high-resolution separated local field spectroscopy. J Magn Reson. 2003 Sep; 164(1):182-6. PMID: 12932472.
        View in: PubMed
      120. Lee S, Mesleh MF, Opella S. Structure and dynamics of a membrane protein in micelles from three solution NMR experiments. J Biomol NMR. 2003 Aug; 26(4):327-34. PMID: 12815259.
        View in: PubMed
      121. Mesleh MF, Opella S. Dipolar Waves as NMR maps of helices in proteins. J Magn Reson. 2003 Aug; 163(2):288-99. PMID: 12914844.
        View in: PubMed
      122. Mesleh MF, Lee S, Veglia G, Thiriot DS, Marassi FM, Opella S. Dipolar waves map the structure and topology of helices in membrane proteins. J Am Chem Soc. 2003 Jul 23; 125(29):8928-35. PMID: 12862490; PMCID: PMC3272074.
      123. Valentine KG, Mesleh MF, Opella S, Ikura M, Ames JB. Structure, topology, and dynamics of myristoylated recoverin bound to phospholipid bilayers. Biochemistry. 2003 Jun 03; 42(21):6333-40. PMID: 12767213.
        View in: PubMed
      124. Zeri AC, Mesleh MF, Nevzorov AA, Opella S. Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6458-63. PMID: 12750469; PMCID: PMC164468.
      125. Zheng S, Strzalka J, Jones DH, Opella S, Blasie JK. Comparative structural studies of Vpu peptides in phospholipid monolayers by x-ray scattering. Biophys J. 2003 Apr; 84(4):2393-415. PMID: 12668448; PMCID: PMC1302806.
      126. Marassi FM, Opella S. Simultaneous assignment and structure determination of a membrane protein from NMR orientational restraints. Protein Sci. 2003 Mar; 12(3):403-11. PMID: 12592011; PMCID: PMC2312444.
      127. Nevzorov AA, Opella S. Structural fitting of PISEMA spectra of aligned proteins. J Magn Reson. 2003 Jan; 160(1):33-9. PMID: 12565046.
        View in: PubMed
      128. Opella S. Membrane protein NMR studies. Methods Mol Biol. 2003; 227:307-20. PMID: 12824655.
        View in: PubMed
      129. Mesleh MF, Valentine KG, Opella S, Louis JM, Gronenborn AM. Myristoylation as a general method for immobilization and alignment of soluble proteins for solid-state NMR structural studies. J Biomol NMR. 2003 Jan; 25(1):55-61. PMID: 12566999.
        View in: PubMed
      130. Montal M, Opella S. The structure of the M2 channel-lining segment from the nicotinic acetylcholine receptor. Biochim Biophys Acta. 2002 Oct 11; 1565(2):287-93. PMID: 12409201.
        View in: PubMed
      131. DeSilva TM, Veglia G, Porcelli F, Prantner AM, Opella S. Selectivity in heavy metal- binding to peptides and proteins. Biopolymers. 2002 Aug 05; 64(4):189-97. PMID: 12115136.
        View in: PubMed
      132. Marassi FM, Opella S. Using pisa pies to resolve ambiguities in angular constraints from PISEMA spectra of aligned proteins. J Biomol NMR. 2002 Jul; 23(3):239-42. PMID: 12238596; PMCID: PMC2920879.
      133. Mesleh MF, Veglia G, DeSilva TM, Marassi FM, Opella S. Dipolar waves as NMR maps of protein structure. J Am Chem Soc. 2002 Apr 24; 124(16):4206-7. PMID: 11960438; PMCID: PMC3272071.
      134. Veglia G, Zeri AC, Ma C, Opella S. Deuterium/hydrogen exchange factors measured by solution nuclear magnetic resonance spectroscopy as indicators of the structure and topology of membrane proteins. Biophys J. 2002 Apr; 82(4):2176-83. PMID: 11916873; PMCID: PMC1302011.
      135. Opella S, DeSilva TM, Veglia G. Structural biology of metal-binding sequences. Curr Opin Chem Biol. 2002 Apr; 6(2):217-23. PMID: 12039007.
        View in: PubMed
      136. Ma C, Marassi FM, Jones DH, Straus SK, Bour S, Strebel K, Schubert U, Oblatt-Montal M, Montal M, Opella S. Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1. Protein Sci. 2002 Mar; 11(3):546-57. PMID: 11847278; PMCID: PMC2373459.
      137. Opella S, Nevzorov A, Mesleh MF, Marassi FM. Structure determination of membrane proteins by NMR spectroscopy. Biochem Cell Biol. 2002; 80(5):597-604. PMID: 12440700; PMCID: PMC3454473.
      138. Valentine KG, Liu SF, Marassi FM, Veglia G, Opella S, Ding FX, Wang SH, Arshava B, Becker JM, Naider F. Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayers. Biopolymers. 2001 Oct 05; 59(4):243-56. PMID: 11473349; PMCID: PMC3282060.
      139. Monette M, Opella S, Greenwood J, Willis AE, Perham RN. Structure of a malaria parasite antigenic determinant displayed on filamentous bacteriophage determined by NMR spectroscopy: implications for the structure of continuous peptide epitopes of proteins. Protein Sci. 2001 Jun; 10(6):1150-9. PMID: 11369853; PMCID: PMC2374004.
      140. Zheng S, Strzalka J, Ma C, Opella S, Ocko BM, Blasie JK. Structural studies of the HIV-1 accessory protein Vpu in langmuir monolayers: synchrotron X-ray reflectivity. Biophys J. 2001 Apr; 80(4):1837-50. PMID: 11259297; PMCID: PMC1301373.
      141. Rosay M, Zeri AC, Astrof NS, Opella S, Herzfeld J, Griffin RG. Sensitivity-enhanced NMR of biological solids: dynamic nuclear polarization of Y21M fd bacteriophage and purple membrane. J Am Chem Soc. 2001 Feb 07; 123(5):1010-1. PMID: 11456650.
        View in: PubMed
      142. Opella S, Ma C, Marassi FM. Nuclear magnetic resonance of membrane-associated peptides and proteins. Methods Enzymol. 2001; 339:285-313. PMID: 11462817; PMCID: PMC3282062.
      143. Ma C, Opella S. Lanthanide ions bind specifically to an added "EF-hand" and orient a membrane protein in micelles for solution NMR spectroscopy. J Magn Reson. 2000 Oct; 146(2):381-4. PMID: 11001856.
        View in: PubMed
      144. Marassi FM, Ma C, Gesell JJ, Opella S. Three-dimensional solid-state NMR spectroscopy is essential for resolution of resonances from in-plane residues in uniformly (15)N-labeled helical membrane proteins in oriented lipid bilayers. J Magn Reson. 2000 May; 144(1):156-61. PMID: 10783286.
        View in: PubMed
      145. Marassi FM, Opella S. A solid-state NMR index of helical membrane protein structure and topology. J Magn Reson. 2000 May; 144(1):150-5. PMID: 10783285; PMCID: PMC3437921.
      146. Marassi FM, Ma C, Gratkowski H, Straus SK, Strebel K, Oblatt-Montal M, Montal M, Opella S. Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14336-41. PMID: 10588706; PMCID: PMC24437.
      147. Marassi FM, Opella S, Juvvadi P, Merrifield RB. Orientation of cecropin A helices in phospholipid bilayers determined by solid-state NMR spectroscopy. Biophys J. 1999 Dec; 77(6):3152-5. PMID: 10585936; PMCID: PMC1300585.
      148. Lorigan GA, McNamara R, Jones RA, Opella S. Magnitudes and orientations of the 15N chemical shift tensor of [1-15N]-2'-deoxyguanosine determined on a polycrystalline sample by two-dimensional solid-state NMR spectroscopy. J Magn Reson. 1999 Oct; 140(2):315-9. PMID: 10497038.
        View in: PubMed
      149. Gu ZT, Opella S. Two- and three-dimensional 1H/13C PISEMA experiments and their application to backbone and side chain sites of amino acids and peptides. J Magn Reson. 1999 Oct; 140(2):340-6. PMID: 10497041.
        View in: PubMed
      150. Ramamoorthy A, Wu CH, Opella S. Experimental aspects of multidimensional solid-state NMR correlation spectroscopy. J Magn Reson. 1999 Sep; 140(1):131-40. PMID: 10479555.
        View in: PubMed
      151. Hashimoto Y, Toma K, Nishikido J, Yamamoto K, Haneda K, Inazu T, Valentine KG, Opella S. Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy. Biochemistry. 1999 Jun 29; 38(26):8377-84. PMID: 10387083.
        View in: PubMed
      152. Gu Z, Opella S. Three-dimensional 13C shift/1H-15N coupling/15N shift solid-state NMR correlation spectroscopy. J Magn Reson. 1999 Jun; 138(2):193-8. PMID: 10341122.
        View in: PubMed
      153. Marassi FM, Gesell JJ, Valente AP, Kim Y, Oblatt-Montal M, Montal M, Opella S. Dilute spin-exchange assignment of solid-state NMR spectra of oriented proteins: acetylcholine M2 in bilayers. J Biomol NMR. 1999 Jun; 14(2):141-8. PMID: 10427741; PMCID: PMC3282054.
      154. Tan WM, Gu Z, Zeri AC, Opella S. Solid-state NMR triple-resonance backbone assignments in a protein. J Biomol NMR. 1999 Apr; 13(4):337-42. PMID: 10353195.
        View in: PubMed
      155. Opella S, Marassi FM, Gesell JJ, Valente AP, Kim Y, Oblatt-Montal M, Montal M. Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat Struct Biol. 1999 Apr; 6(4):374-9. PMID: 10201407; PMCID: PMC3282055.
      156. Tan WM, Jelinek R, Opella S, Malik P, Terry TD, Perham RN. Effects of temperature and Y21M mutation on conformational heterogeneity of the major coat protein (pVIII) of filamentous bacteriophage fd. J Mol Biol. 1999 Feb 26; 286(3):787-96. PMID: 10024451.
        View in: PubMed
      157. Marassi FM, Opella S. NMR structural studies of membrane proteins. Curr Opin Struct Biol. 1998 Oct; 8(5):640-8. PMID: 9818270; PMCID: PMC3282058.
      158. Kim Y, Valentine K, Opella S, Schendel SL, Cramer WA. Solid-state NMR studies of the membrane-bound closed state of the colicin E1 channel domain in lipid bilayers. Protein Sci. 1998 Feb; 7(2):342-8. PMID: 9521110; PMCID: PMC2143909.
      159. Bechinger B, Zasloff M, Opella S. Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J. 1998 Feb; 74(2 Pt 1):981-7. PMID: 9533709; PMCID: PMC1302577.
      160. McCoy M, Stavridi ES, Waterman JL, Wieczorek AM, Opella S, Halazonetis TD. Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain. EMBO J. 1997 Oct 15; 16(20):6230-6. PMID: 9321402; PMCID: PMC1326307.
      161. Opella S. NMR and membrane proteins. Nat Struct Biol. 1997 Oct; 4 Suppl:845-8. PMID: 9377156.
        View in: PubMed
      162. Marassi FM, Ramamoorthy A, Opella S. Complete resolution of the solid-state NMR spectrum of a uniformly 15N-labeled membrane protein in phospholipid bilayers. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8551-6. PMID: 9238014; PMCID: PMC23006.
      163. Almeida FC, Opella S. fd coat protein structure in membrane environments: structural dynamics of the loop between the hydrophobic trans-membrane helix and the amphipathic in-plane helix. J Mol Biol. 1997 Jul 18; 270(3):481-95. PMID: 9237913.
        View in: PubMed
      164. Steele RA, Opella S. Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system. Biochemistry. 1997 Jun 10; 36(23):6885-95. PMID: 9188683.
        View in: PubMed
      165. Jelinek R, Terry TD, Gesell JJ, Malik P, Perham RN, Opella S. NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein. J Mol Biol. 1997 Mar 07; 266(4):649-55. PMID: 9102458.
        View in: PubMed
      166. Jelinek R, Valente AP, Valentine KG, Opella S. Two-dimensional NMR spectroscopy of peptides on beads. J Magn Reson. 1997 Mar; 125(1):185-7. PMID: 9245378.
        View in: PubMed
      167. Gesell J, Zasloff M, Opella S. Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution. J Biomol NMR. 1997 Feb; 9(2):127-35. PMID: 9090128.
        View in: PubMed
      168. Almeida FC, Opella S. Measurement of 1H T1 rho in a uniformly 15N-labeled protein in solution with heteronuclear two-dimensional spectroscopy. J Magn Reson. 1997 Feb; 124(2):509-11. PMID: 9169225.
        View in: PubMed
      169. Klassen RB, Opella S. NMR studies of peptides and proteins associated with membranes. Methods Mol Biol. 1997; 60:271-97. PMID: 9276251.
        View in: PubMed
      170. Bechinger B, Gierasch LM, Montal M, Zasloff M, Opella S. Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopy. Solid State Nucl Magn Reson. 1996 Dec; 7(3):185-91. PMID: 9050156.
        View in: PubMed
      171. Howard KP, Opella S. High-resolution solid-state NMR spectra of integral membrane proteins reconstituted into magnetically oriented phospholipid bilayers. J Magn Reson B. 1996 Jul; 112(1):91-4. PMID: 8661314.
        View in: PubMed
      172. Ramamoorthy A, Gierasch LM, Opella S. Three-dimensional solid-state NMR correlation experiment with 1H homonuclear spin exchange. J Magn Reson B. 1996 Apr; 111(1):81-4. PMID: 8620287.
        View in: PubMed
      173. Ramamoorthy A, Gierasch LM, Opella S. Resolved two-dimensional anisotropic-chemical-shift/heteronuclear dipolar coupling powder-pattern spectra by three-dimensional solid-state NMR spectroscopy. J Magn Reson B. 1996 Jan; 110(1):102-6. PMID: 8556232.
        View in: PubMed
      174. Artz PG, Valentine KG, Opella S, Lu P. Lac repressor-operator interaction: N-terminal peptide backbone 1H and 15N chemical shifts upon complex formation with DNA. J Mol Recognit. 1996 Jan-Feb; 9(1):13-22. PMID: 8723315.
        View in: PubMed
      175. Ramamoorthy A, Marassi FM, Zasloff M, Opella S. Three-dimensional solid-state NMR spectroscopy of a peptide oriented in membrane bilayers. J Biomol NMR. 1995 Nov; 6(3):329-34. PMID: 8520224; PMCID: PMC3282056.
      176. Tobias DJ, Gesell J, Klein ML, Opella S. A simple protocol for identification of helical and mobile residues in membrane proteins. J Mol Biol. 1995 Oct 27; 253(3):391-5. PMID: 7473722.
        View in: PubMed
      177. Ramamoorthy A, Gierasch LM, Opella S. Four-dimensional solid-state NMR experiment that correlates the chemical-shift and dipolar-coupling frequencies of two heteronuclei with the exchange of dilute-spin magnetization. J Magn Reson B. 1995 Oct; 109(1):112-6. PMID: 8581306.
        View in: PubMed
      178. Ramamoorthy A, Opella S. Two-dimensional chemical shift/heteronuclear dipolar coupling spectra obtained with polarization inversion spin exchange at the magic angle and magic-angle sample spinning (PISEMAMAS). Solid State Nucl Magn Reson. 1995 Aug; 4(6):387-92. PMID: 8581437.
        View in: PubMed
      179. Ramamoorthy A, Wu CH, Opella S. Three-dimensional solid-state NMR experiment that correlates the chemical shift and dipolar coupling frequencies of two heteronuclei. J Magn Reson B. 1995 Apr; 107(1):88-90. PMID: 7743077.
        View in: PubMed
      180. Opella S, Kim Y, McDonnell P. Experimental nuclear magnetic resonance studies of membrane proteins. Methods Enzymol. 1994; 239:536-60. PMID: 7830598.
        View in: PubMed
      181. Opella S. Solid-state NMR structural studies of proteins. Annu Rev Phys Chem. 1994; 45:659-83. PMID: 7811357.
        View in: PubMed
      182. Bechinger B, Zasloff M, Opella S. Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy. Protein Sci. 1993 Dec; 2(12):2077-84. PMID: 8298457; PMCID: PMC2142334.
      183. McDonnell PA, Shon K, Kim Y, Opella S. fd coat protein structure in membrane environments. J Mol Biol. 1993 Oct 05; 233(3):447-63. PMID: 8411155.
        View in: PubMed
      184. Tobias DJ, Klein ML, Opella S. Molecular dynamics simulation of Pf1 coat protein. Biophys J. 1993 Mar; 64(3):670-5. PMID: 8471719; PMCID: PMC1262379.
      185. Bechinger B, Zasloff M, Opella S. Structure and interactions of magainin antibiotic peptides in lipid bilayers: a solid-state nuclear magnetic resonance investigation. Biophys J. 1992 Apr; 62(1):12-4. PMID: 1600092; PMCID: PMC1260469.
      186. Bechinger B, Kim Y, Chirlian LE, Gesell J, Neumann JM, Montal M, Tomich J, Zasloff M, Opella S. Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy. J Biomol NMR. 1991 Jul; 1(2):167-73. PMID: 1726781.
        View in: PubMed
      187. Shon KJ, Kim Y, Colnago LA, Opella S. NMR studies of the structure and dynamics of membrane-bound bacteriophage Pf1 coat protein. Science. 1991 May 31; 252(5010):1303-5. PMID: 1925542.
        View in: PubMed
      188. Nambudripad R, Stark W, Opella S, Makowski L. Membrane-mediated assembly of filamentous bacteriophage Pf1 coat protein. Science. 1991 May 31; 252(5010):1305-8. PMID: 1925543.
        View in: PubMed
      189. Opella S, Stewart PL. Solid-state nuclear magnetic resonance structural studies of proteins. Methods Enzymol. 1989; 176:242-75. PMID: 2811689.
        View in: PubMed
      190. Thomas GJ, Prescott B, Opella S, Day LA. Sugar pucker and phosphodiester conformations in viral genomes of filamentous bacteriophages: fd, If1, IKe, Pf1, Xf, and Pf3. Biochemistry. 1988 Jun 14; 27(12):4350-7. PMID: 3166982.
        View in: PubMed
      191. Schiksnis RA, Bogusky MJ, Opella S. Secondary structure of filamentous bacteriophage coat protein is preserved in lipid environments. J Mol Biol. 1988 Apr 20; 200(4):741-3. PMID: 3411609.
        View in: PubMed
      192. Bogusky MJ, Leo GC, Opella S. Comparison of the dynamics of the membrane-bound form of fd coat protein in micelles and in bilayers by solution and solid-state nitrogen-15 nuclear magnetic resonance spectroscopy. Proteins. 1988; 4(2):123-30. PMID: 3227013.
        View in: PubMed
      193. Guilford WJ, Schneider DM, Labovitz J, Opella S. High resolution solid state C NMR spectroscopy of sporopollenins from different plant taxa. Plant Physiol. 1988 Jan; 86(1):134-6. PMID: 16665854.
        View in: PubMed
      194. Schiksnis RA, Bogusky MJ, Tsang P, Opella S. Structure and dynamics of the Pf1 filamentous bacteriophage coat protein in micelles. Biochemistry. 1987 Mar 10; 26(5):1373-81. PMID: 3567175.
        View in: PubMed
      195. Colnago LA, Valentine KG, Opella S. Dynamics of fd coat protein in the bacteriophage. Biochemistry. 1987 Feb 10; 26(3):847-54. PMID: 3552033.
        View in: PubMed
      196. Leo GC, Colnago LA, Valentine KG, Opella S. Dynamics of fd coat protein in lipid bilayers. Biochemistry. 1987 Feb 10; 26(3):854-62. PMID: 3552034.
        View in: PubMed
      197. Opella S, Stewart PL, Valentine KG. Protein structure by solid-state NMR spectroscopy. Q Rev Biophys. 1987 Feb; 19(1-2):7-49. PMID: 3306759.
        View in: PubMed
      198. Tsang P, Opella S. Pf1 virus particle dynamics. Biopolymers. 1986 Oct; 25(10):1859-64. PMID: 3096396.
        View in: PubMed
      199. Mueller L, Frey MH, Rockwell AL, Gierasch LM, Opella S. Dynamics of a hydrophobic peptide in membrane bilayers by solid-state nuclear magnetic resonance. Biochemistry. 1986 Feb 11; 25(3):557-61. PMID: 3754152.
        View in: PubMed
      200. Opella S. Protein dynamics by solid state nuclear magnetic resonance. Methods Enzymol. 1986; 131:327-61. PMID: 3773765.
        View in: PubMed
      201. Valentine KG, Schneider DM, Leo GC, Colnago LA, Opella S. Structure and Dynamics of FD Coat Protein. Biophys J. 1986 Jan; 49(1):36-8. PMID: 19431639.
        View in: PubMed
      202. Cross TA, Opella S. Protein structure by solid state nuclear magnetic resonance. Residues 40 to 45 of bacteriophage fd coat protein. J Mol Biol. 1985 Apr 05; 182(3):367-81. PMID: 4009711.
        View in: PubMed
      203. Bogusky MJ, Tsang P, Opella S. One- and two- dimensional 15N/1H NMR of filamentous phage coat proteins in solution. Biochem Biophys Res Commun. 1985 Mar 15; 127(2):540-5. PMID: 3977936.
        View in: PubMed
      204. Cross TA, Opella S, Stubbs G, Caspar DL. 31P nuclear magnetic resonance of the RNA in tobacco mosaic virus. J Mol Biol. 1983 Nov 15; 170(4):1037-43. PMID: 6644812.
        View in: PubMed
      205. Cross TA, Tsang P, Opella S. Comparison of protein and deoxyribonucleic acid backbone structures in fd and Pf1 bacteriophages. Biochemistry. 1983 Feb 15; 22(4):721-6. PMID: 6340725.
        View in: PubMed
      206. Cross TA, Opella S. Protein dynamics by solid-state nuclear magnetic resonance spectroscopy. Peptide backbone of the coat protein in fd bacteriophage. J Mol Biol. 1982 Aug 15; 159(3):543-9. PMID: 7166755.
        View in: PubMed
      207. Gall CM, Cross TA, DiVerdi JA, Opella S. Protein dynamics by solid-state NMR: aromatic rings of the coat protein in fd bacteriophage. Proc Natl Acad Sci U S A. 1982 Jan; 79(1):101-5. PMID: 6948294; PMCID: PMC345669.
      208. Fritzsche H, Cross TA, Opella S, Kallenbach NR. Structure and architecture of the bacterial virus fd. An infrared linear dichroism study. Biophys Chem. 1981 Nov; 14(3):283-91. PMID: 7326351.
        View in: PubMed
      209. DiVerdi JA, Opella S, Ma RI, Kallenbach NR, Seeman NC. 31P NMR of DNA in eukaryotic chromosomal complexes. Biochem Biophys Res Commun. 1981 Oct 15; 102(3):885-90. PMID: 7306194.
        View in: PubMed
      210. DiVerdi JA, Opella S. Dynamics of B-DNA in the solid state. J Mol Biol. 1981 Jun 25; 149(2):307-11. PMID: 7310883.
        View in: PubMed
      211. Opella S, Wise WB, DiVerdi JA. Deoxyribonucleic acid dynamics from phosphorus-31 nuclear magnetic resonance. Biochemistry. 1981 Jan 20; 20(2):284-90. PMID: 7193483.
        View in: PubMed
      212. DiVerdi JA, Opella S. Phosphorus-31 nuclear magnetic resonance of fd virus. Biochemistry. 1981 Jan 20; 20(2):280-4. PMID: 7008839.
        View in: PubMed
      213. Cross TA, Opella S. Hydrogen-1 and carbon-13 nuclear magnetic resonance of the aromatic residues of fd coat protein. Biochemistry. 1981 Jan 20; 20(2):290-7. PMID: 7008840.
        View in: PubMed
      214. Cross TA, Gall CM, Opella S. NMR studies of filamentous bacteriophage assembly. Prog Clin Biol Res. 1981; 64:457-65. PMID: 7330059.
        View in: PubMed
      215. Opella S, Cross TA, DiVerdi JA, Sturm CF. Nuclear magnetic resonance of the filamentous bacteriophage fd. Biophys J. 1980 Oct; 32(1):531-48. PMID: 7018608; PMCID: PMC1327349.
      216. Cross TA, Opella S. Structural properties of fd coat protein in sodium dodecyl sulfate micelles. Biochem Biophys Res Commun. 1980 Jan 29; 92(2):478-84. PMID: 6986868.
        View in: PubMed
      217. Cross TA, Opella S. NMR of fd coat protein. J Supramol Struct. 1979; 11(2):139-45. PMID: 44890.
        View in: PubMed
      218. Moo-Penn WF, Bechtel KC, Schmidt RM, Johnson MH, Jue DL, Schmidt DE, Dunlap WM, Opella S, Bonaventura J, Bonaventura C. Hemoglobin Raleigh (beta1 valine replaced by acetylalanine). Structural and functional characterization. Biochemistry. 1977 Nov 01; 16(22):4872-9. PMID: 20942.
        View in: PubMed
      219. Opella S. Biological nuclear magnetic resonance spectroscopy. Science. 1977 Oct 14; 198(4313):158-65. PMID: 20662.
        View in: PubMed
      220. Matthews HR, Matthews KS, Opella S. Selectively deuterated amino acid analogues. Synthesis, incorporation into proteins and NMR properties. Biochim Biophys Acta. 1977 Mar 29; 497(1):1-13. PMID: 321035.
        View in: PubMed
      221. Nelson DJ, Opella S, Jardetzky O. 13C nuclear magnetic resonance study of molecular motions and conformational transitions in muscle calcium binding parvalbumins. Biochemistry. 1976 Dec 14; 15(25):5552-60. PMID: 999828.
        View in: PubMed
      222. Opella S, Yesinowski JP, Waugh JS. Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):3812-5. PMID: 1069266; PMCID: PMC431220.
      223. Roberts MF, Opella S, Schaffer MH, Phillips HM, Stark GR. Evidence from 13C NMR for protonation of carbamyl-P and N-(phosphonacetyl)-L-aspartate in the active site of aspartate transcarbamylase. J Biol Chem. 1976 Oct 10; 251(19):5976-85. PMID: 9410.
        View in: PubMed
      224. Cozzone PJ, Opella S, Jardetzky O, Berthou J, Jollès P. Detection of new temperature-dependent conformational transition in lysozyme by carbon-13 nuclear magnetic resonance spectroscopy. Proc Natl Acad Sci U S A. 1975 Jun; 72(6):2095-8. PMID: 1056017; PMCID: PMC432702.
      225. Bauer DR, Opella S, Nelson DJ, Pecora R. Letter: Depolarized light scattering and carbon nuclear resonance measurements of the isotropic rotational correlation time of muscle calcium binding protein. J Am Chem Soc. 1975 Apr 30; 97(9):2580-2. PMID: 1133427.
        View in: PubMed
      226. Opella S, Nelson DJ, Jardetzyk O. Letter: Carbon magnetic resonance study of the conformational changes in carp muscle calcium binding parvalbumin. J Am Chem Soc. 1974 Oct 30; 96(22):7157-9. PMID: 4474190.
        View in: PubMed