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B S L Hurst

Photo of B S L Hurst
Title(s)Clinical Professor, Herbert Wertheim School of Public Health & Human Longevity Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Samantha Hurst, PhD, MA is a Health Sciences Clinical Professor in the Herbert Wertheim School of Public Health and Longevity Science. As a medical anthropologist, her research focuses on community health with emphasis on behavioral and cultural interventions for cancer prevention and early detection. Her work addresses two phases of the cancer journey. The first is early detection and screening, where she studies how patients interpret and act on screening information. The second is the diagnosis-to-treatment initiation phase, where she examines how patients navigate the complex transition into care. Her research goals are to develop and test strategies that improve comprehension, follow-through, and timely access to breast and cervical cancer care, and to prepare underserved communities for emerging early detection technologies, such as liquid biopsy and fragmentomics.

    Dr. Hurst is recognized for her expertise in participatory research frameworks that position community partners as equal drivers of the research process. She uses qualitative and mixed-methods approaches to document how communities define priorities, shape interventions, and interpret health challenges in ways that reflect their lived experience. By combining rigorous methodological design with authentic partnership, her work generates actionable knowledge that is both scientifically credible and responsive to community needs. She is guided by the conviction that progress in public health depends on the combination of methodological rigor and community trust working hand in hand.

    A dedicated educator and mentor, Dr. Hurst teaches in the Master of Public Health (MPH) and Joint Doctoral Program in Public Health (JDP). She trains future public health leaders in qualitative methods, mixed methods, and community-based research. She also integrates a bio-cultural ethics framework into her teaching and scholarship, ensuring that projects uphold ethical integrity while producing knowledge that communities find meaningful.

    Dr. Hurst received her Ph.D. in Biological Anthropology from the University of Tennessee, Knoxville, and completed her post-doctoral fellowship in Cultural Psychiatry and Medical Anthropology at the Alcohol Research Center at The Scripps Research Institute in La Jolla.

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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease. J Med Chem. 2025 Apr 10; 68(7):7003-7030. Tuttle JB, Allais C, Allerton CMN, Anderson AS, Arcari JT, Aschenbrenner LM, Avery M, Bellenger J, Berritt S, Boras B, Boscoe BP, Buzon LM, Cardin RD, Carlo AA, Coffman KJ, Dantonio A, Di L, Eng H, Farley KA, Ferre RA, Gajiwala KS, Gibson SA, Greasley SE, Hurst BL, Kadar EP, Kalgutkar AS, Lachapelle EA, Lanyon LF, Lee J, Lee J, Lian Y, Liu W, Martínez-Alsina LA, Mason SW, Noell S, Novak J, Obach RS, Ogilvie K, O'Neil SV, Ostner G, Owen DR, Patel NC, Pettersson M, Singh RS, Rai DK, Reese MR, Sakata S, Sammons MF, Sathish JG, Sharma R, Steppan CM, Stewart A, Updyke L, Verhoest PR, Wei L, Wright SW, Yang E, Yang Q, Zhu Y. PMID: 40019854.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19. J Med Chem. 2024 08 22; 67(16):13550-13571. Allerton CMN, Arcari JT, Aschenbrenner LM, Avery M, Bechle BM, Behzadi MA, Boras B, Buzon LM, Cardin RD, Catlin NR, Carlo AA, Coffman KJ, Dantonio A, Di L, Eng H, Farley KA, Ferre RA, Gernhardt SS, Gibson SA, Greasley SE, Greenfield SR, Hurst BL, Kalgutkar AS, Kimoto E, Lanyon LF, Lovett GH, Lian Y, Liu W, Martínez Alsina LA, Noell S, Obach RS, Owen DR, Patel NC, Rai DK, Reese MR, Rothan HA, Sakata S, Sammons MF, Sathish JG, Sharma R, Steppan CM, Tuttle JB, Verhoest PR, Wei L, Yang Q, Yurgelonis I, Zhu Y. PMID: 38687966; PMCID: PMC11345836.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    3. Improved virus concentration methods for wash waters from decontamination of permeable and non-permeable surfaces. J Virol Methods. 2023 12; 322:114826. Hurst BN, Korajkic A, Pemberton A, McMinn BR. PMID: 37778537; PMCID: PMC10841435.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    4. Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2. Nat Commun. 2023 03 28; 14(1):1733. Sanders BC, Pokhrel S, Labbe AD, Mathews II, Cooper CJ, Davidson RB, Phillips G, Weiss KL, Zhang Q, O'Neill H, Kaur M, Schmidt JG, Reichard W, Surendranathan S, Parvathareddy J, Phillips L, Rainville C, Sterner DE, Kumaran D, Andi B, Babnigg G, Moriarty NW, Adams PD, Joachimiak A, Hurst BL, Kumar S, Butt TR, Jonsson CB, Ferrins L, Wakatsuki S, Galanie S, Head MS, Parks JM. PMID: 36977673; PMCID: PMC10044120.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    5. Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice. ACS Omega. 2022 Sep 13; 7(36):31935-31944. Puhl AC, Gomes GF, Damasceno S, Fritch EJ, Levi JA, Johnson NJ, Scholle F, Premkumar L, Hurst BL, Lee-Montiel F, Veras FP, Batah SS, Fabro AT, Moorman NJ, Yount BL, Dickmander RJ, Baric RS, Pearce KH, Cunha FQ, Alves-Filho JC, Cunha TM, Ekins S. PMID: 36097511; PMCID: PMC9454268.
      View in: PubMed   Mentions: 9  
    6. Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2. Nat Med. 2022 09; 28(9):1944-1955. Hagey RJ, Elazar M, Pham EA, Tian S, Ben-Avi L, Bernardin-Souibgui C, Yee MF, Moreira FR, Rabinovitch MV, Meganck RM, Fram B, Beck A, Gibson SA, Lam G, Devera J, Kladwang W, Nguyen K, Xiong A, Schaffert S, Avisar T, Liu P, Rustagi A, Fichtenbaum CJ, Pang PS, Khatri P, Tseng CT, Taubenberger JK, Blish CA, Hurst BL, Sheahan TP, Das R, Glenn JS. PMID: 35982307; PMCID: PMC10132811.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    7. Through our own eyes and voices: The experiences of those "left-behind" in rural, indigenous migrant-sending communities in western Guatemala. J Migr Health. 2022; 5:100096. Ciborowski HM, Hurst S, Perez RL, Swanson K, Leas E, Brouwer KC, Shakya HB. PMID: 35519077; PMCID: PMC9062241.
      View in: PubMed   Mentions: 2  
    8. Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice. bioRxiv. 2021 Dec 20. Puhl AC, Gomes GF, Damasceno S, Fritch EJ, Levi JA, Johnson NJ, Scholle F, Premkumar L, Hurst BL, LeeMontiel F, Veras FP, Batah SS, Fabro AT, Moorman NJ, Yount BL, Dickmander R, Baric R, Pearce KH, Cunha FQ, Alves-Filho JC, Cunha TM, Ekins S. PMID: 34981062; PMCID: PMC8722599.
      View in: PubMed   Mentions:
    9. Role of affective reactivity induced by cigarette packaging including graphic warning labels: the CASA Study. Tob Control. 2023 05; 32(3):315-322. Stone M, Strong D, Dimofte C, Brighton E, Oratowski J, Yang T, Alkuzweny M, Asslani A, Velasco K, Skipworth M, Crespo NC, Hurst S, Leas EC, Pulvers K, Pierce JP. PMID: 34511408; PMCID: PMC8917242.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Machine Learning Models Identify Inhibitors of SARS-CoV-2. J Chem Inf Model. 2021 09 27; 61(9):4224-4235. Gawriljuk VO, Zin PPK, Puhl AC, Zorn KM, Foil DH, Lane TR, Hurst B, Tavella TA, Costa FTM, Lakshmanane P, Bernatchez J, Godoy AS, Oliva G, Siqueira-Neto JL, Madrid PB, Ekins S. PMID: 34387990; PMCID: PMC8574161.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    11. Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles. Vaccine. 2021 09 07; 39(38):5410-5421. Stinson JA, Boopathy AV, Cieslewicz BM, Zhang Y, Hartman NW, Miller DP, Dirckx M, Hurst BL, Tarbet EB, Kluge JA, Kosuda KM. PMID: 34391593; PMCID: PMC8405573.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    12. Effect of Graphic Warning Labels on Cigarette Packs on US Smokers' Cognitions and Smoking Behavior After 3 Months: A Randomized Clinical Trial. JAMA Netw Open. 2021 08 02; 4(8):e2121387. Strong DR, Pierce JP, Pulvers K, Stone MD, Villaseñor A, Pu M, Dimofte CV, Leas EC, Oratowski J, Brighton E, Hurst S, Kealey S, Chen R, Messer K. PMID: 34347057; PMCID: PMC8339936.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    13. High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity. PLoS One. 2021; 16(4):e0250019. Choi R, Zhou M, Shek R, Wilson JW, Tillery L, Craig JK, Salukhe IA, Hickson SE, Kumar N, James RM, Buchko GW, Wu R, Huff S, Nguyen TT, Hurst BL, Cherry S, Barrett LK, Hyde JL, Van Voorhis WC. PMID: 33886614; PMCID: PMC8062000.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    14. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. ACS Chem Biol. 2021 04 16; 16(4):642-650. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33787221.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    15. Out-of-clinic and self-managed abortion in Bangladesh: menstrual regulation provider perspectives. Reprod Health. 2021 Mar 25; 18(1):69. Crouthamel B, Pearson E, Tilford S, Hurst S, Paul D, Aqtar F, Silverman J, Averbach S. PMID: 33766050; PMCID: PMC7993471.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms. ACS Omega. 2021 Mar 23; 6(11):7454-7468. Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Fintelman-Rodrigues N, Tavella TA, Maranhão Costa FT, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, Levi JA, Johnson NJ, Kisthardt SC, Scholle F, Souza TML, Moorman NJ, Baric RS, Madrid PB, Ekins S. PMID: 33778258; PMCID: PMC7992063.
      View in: PubMed   Mentions: 50  
    17. Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms. bioRxiv. 2020 Dec 02. Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Tavella TA, Costa FTM, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, Levi JA, Johnson NJ, Kisthardt SC, Scholle F, Souza TML, Moorman NJ, Baric RS, Madrid P, Ekins S. PMID: 33299990; PMCID: PMC7724658.
      View in: PubMed   Mentions:
    18. A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells. bioRxiv. 2020 Oct 30. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Frueh F, Hurst BL, Wang H, Kocurek KI, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33140046; PMCID: PMC7605553.
      View in: PubMed   Mentions: 1  
    19. Real-world exposure to graphic warning labels on cigarette packages in US smokers: The CASA randomized trial protocol. Contemp Clin Trials. 2020 11; 98:106152. Pierce JP, Strong DR, Stone MD, Villaseñor A, Dimofte CV, Leas EC, Oratowski J, Brighton E, Hurst S, Pulvers K, Kealey S, Chen R, Messer K. PMID: 32966877; PMCID: PMC7502239.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    20. A Remotely Delivered, Peer-Led Physical Activity Intervention for Younger Breast Cancer Survivors (Pink Body Spirit): Protocol for a Feasibility Study and Mixed Methods Process Evaluation. JMIR Res Protoc. 2020 Jul 08; 9(7):e18420. Weiner LS, Nagel S, Su HI, Hurst S, Hartman SJ. PMID: 32673270; PMCID: PMC7381067.
      View in: PubMed   Mentions: 5     Fields:    
    21. Exploring Physician Attitudes Regarding Electronic Documentation of E-cigarette Use: A Qualitative Study. Tob Use Insights. 2018; 11:1179173X18782879. Hurst S, Conway M. PMID: 30046257; PMCID: PMC6055248.
      View in: PubMed   Mentions: 8  
    22. Participants' Perceptions on the Use of Wearable Devices to Reduce Sitting Time: Qualitative Analysis. JMIR Mhealth Uhealth. 2018 Mar 31; 6(3):e73. Takemoto M, Lewars B, Hurst S, Crist K, Nebeker C, Madanat H, Nichols J, Rosenberg DE, Kerr J. PMID: 29599105; PMCID: PMC5897621.
      View in: PubMed   Mentions: 4     Fields:    
    23. Yoga therapy for military personnel and veterans: Qualitative perspectives of yoga students and instructors. Complement Ther Med. 2018 Oct; 40:222-229. Hurst S, Maiya M, Casteel D, Sarkin AJ, Libretto S, Elwy AR, Park CL, Groessl EJ. PMID: 30219455; PMCID: PMC6935718.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Health Outcomes and Costs Associated with the Provision of Culturally Competent Services for Underrepresented Ethnic Populations with Severe Mental Illness. Adm Policy Ment Health. 2017 Sep; 44(5):782-791. Gilmer T, Henwood B, McGovern N, Hurst S, Burgdorf J, Innes-Gomberg D. PMID: 28050652.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Implementation of Age-Specific Services for Transition-Age Youths in California. Psychiatr Serv. 2016 09 01; 67(9):970-6. Ojeda VD, Hiller SP, Hurst S, Jones N, McMenamin S, Burgdorf J, Gilmer TP. PMID: 27133720.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. The Use of Qualitative Methods in Developing Implementation Strategies in Prevention Research for Stroke Survivors in Nigeria. J Clin Hypertens (Greenwich). 2016 10; 18(10):1015-1021. Hurst S, Arulogun O, Owolabi MO, Akinyemi RO, Uvere E, Warth S, Fakunle G, Ovbiagele B. PMID: 27038071; PMCID: PMC8031481.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Implementing Tobacco Control Programs in Homeless Shelters: A Mixed-Methods Study. Health Promot Pract. 2016 07; 17(4):501-11. Vijayaraghavan M, Hurst S, Pierce JP. PMID: 26678988.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    28. A Qualitative Examination of Smoke-Free Policies and Electronic Cigarettes Among Sheltered Homeless Adults. Am J Health Promot. 2017 05; 31(3):243-250. Vijayaraghavan M, Hurst S, Pierce JP. PMID: 26559719.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansPHPublic Health
    29. An Exercise-Based Program for Veterans with Substance Use Disorders: Formative Research. J Psychoactive Drugs. 2015 Jul-Aug; 47(3):248-57. Linke SE, Noble M, Hurst S, Strong DR, Redwine L, Norman SB, Lindamer LA. PMID: 26098629.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Cost and cost-effectiveness analysis of a bundled intervention to enhance outcomes after stroke in Nigeria: Rationale and design. eNeurologicalSci. 2015 Jun; 1(2):38-45. Olaniyan O, Owolabi MO, Akinyemi RO, Salako BL, Hurst S, Arulogun O, Gebregziabher M, Uvere E, Ovbiagele B. PMID: 26640824; PMCID: PMC4667801.
      View in: PubMed   Mentions: 1  
    31. Pretesting Qualitative Data Collection Procedures to Facilitate Methodological Adherence and Team Building in Nigeria. Int J Qual Methods. 2015; 14:53-64. Hurst S, Arulogun OS, Owolabi AO, Akinyemi R, Uvere E, Warth S, Ovbiagele B. PMID: 25866494; PMCID: PMC4393011.
      View in: PubMed   Mentions: 16  
    32. Tailored Hospital-based Risk Reduction to Impede Vascular Events After Stroke (THRIVES) study: qualitative phase protocol. Crit Pathw Cardiol. 2014 Mar; 13(1):29-35. Owolabi MO, Akinyemi RO, Hurst S, Arulogun O, Olaniyan O, Gebregziabher M, Salako BL, Ovbiagele B. PMID: 24526149; PMCID: PMC4134882.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    33. vTrain: a novel curriculum for patient surge training in a multi-user virtual environment (MUVE). Prehosp Disaster Med. 2013 Jun; 28(3):215-22. Greci LS, Ramloll R, Hurst S, Garman K, Beedasy J, Pieper EB, Huang R, Higginbotham E, Agha Z. PMID: 23388521.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Building community involvement in cross-cultural Indigenous health programs. Int J Qual Health Care. 2006 Aug; 18(4):294-8. Hurst S, Nader P. PMID: 16835433.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
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