Patricia Thistlethwaite

Title(s)Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview

    Our lab focuses on understanding the molecular mechanism of pulmonary arterial hypertension and coronary vascular development. We are interested in how arteries and veins are specified and how vessels develop normal and pathologic smooth muscle cell investment.

    Research Topics

  • Angiogenesis

  • Cardiovascular Disease

  • Cell Biology

  • Development

  • Molecular Biology

  • Translational Research

  • Current Project Titles

  • The role of Notch3 signaling in pulmonary arterial hypertension

  • ERG-APJ signaling influences the development of pulmonary veno-occlusive disease in humans and mice

  • Molecular signals controlling coronary artery and venous development

  • Profile

    Dr. Patricia A. Thistlethwaite is a cardiothoracic surgeon and researcher who specializes in adult cardiac surgery and molecular biology. She performs the full range of cardiothoracic surgeries including heart and lung transplantation, coronary artery bypass surgery, valve repair and replacement, and general thoracic operations.

    Dr. Thistlethwaite is head of a molecular biology laboratory in the Division of Cardiothoracic Surgery. Her research focuses on molecular causes of pulmonary hypertension, mechanisms of coronary arterial and venous differentiation and angiogenesis, and the genetics of cardiac development. She leads a number of major investigations including several National Institutes of Health-funded studies and a Center for Medical Research and Education Fund (CMREF) project studying the causes, prevention, and treatment of pulmonary arterial hypertension.

    Dr. Thistlethwaite also collaborates with Dr. Jason Yuan of the Division of Pulmonary and Critical Care Medicine in the UC San Diego Department of Medicine in two NIH basic science studies, one on the genetic basis of idiopathic pulmonary arterial hypertension and one on the molecular biology of the lung. In addition, she collaborates with Dr. Paul Insel in the Department of Pharmacology in investigating caveolae expression in pulmonary vascular remodeling.

    As Program Director of the UC San Diego Cardiovascular and Thoracic Surgery Residency Program, Dr. Thistlethwaite is the first woman in the United States to be a cardiothoracic surgery program director. She was elected as a member of the American Association for Thoracic Surgery, the most prestigious society for cardiothoracic surgeons, in April 2006

    Collapse Research 
    Collapse Research Activities and Funding
    Small Molecule NOTCH Inhibitors for the treatment of pulmonary hypertension
    NIH R01HL132225Jun 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    NOTCH3 Signaling in Pulmonary Hypertension
    NIH R01HL119543Sep 1, 2014 - May 31, 2020
    Role: Principal Investigator
    Molecular Mechanisms of Pulmonary Hypertension
    NIH R01HL070852Jul 1, 2002 - Jun 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension. Circulation. 2024 Apr 01. Shen H, Gao Y, Ge D, Tan M, Yin Q, Wei TW, He F, Lee TY, Li Z, Chen Y, Yang Q, Liu Z, Li X, Chen Z, Yang Y, Zhang Z, Thistlethwaite PA, Wang J, Malhotra A, Yuan JX, Shyy JY, Gong K. PMID: 38557054.
      View in: PubMed   Mentions:    Fields:    
    2. Surgical management of left bundle branch pacing lead causing septal and left ventricular perforation. HeartRhythm Case Rep. 2023 Aug; 9(8):520-523. Hernandez M, Puerta C, Thareja N, Zhang Y, Pollema T, Thistlethwaite P. PMID: 37614392; PMCID: PMC10444550.
      View in: PubMed   Mentions: 1  
    3. MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension. Circ Res. 2022 Oct 28; 131(10):828-841. Wang C, Xing Y, Zhang J, He M, Dong J, Chen S, Wu H, Huang HY, Chou CH, Bai L, He F, She J, Su A, Wang Y, Thistlethwaite PA, Huang HD, Yuan JX, Yuan ZY, Shyy JY. PMID: 36252121.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells. Am J Physiol Cell Physiol. 2022 Oct 01; 323(4):C959-C973. Zhao T, Parmisano S, Soroureddin Z, Zhao M, Yung L, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35968892; PMCID: PMC9485000.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Racial and ethnic variation in referral times for thoracic oncologic surgery in a major metropolitan area. J Thorac Cardiovasc Surg. 2022 Jun 08. Hernandez M, Winicki N, Kadivar A, Alvarez S, Zhang Y, Maguire S, Thareja N, Onaitis M, Boys J, Thistlethwaite PA. PMID: 35863965.
      View in: PubMed   Mentions: 1     Fields:    
    6. JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension. Sci Transl Med. 2022 05 04; 14(643):eabl5471. Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, Yuan JX, Shyy J, Thistlethwaite PA. PMID: 35507674.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    7. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2022 05 01; 322(5):L737-L760. Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 35318857; PMCID: PMC9076422.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 04 11; 57(7):839-853.e6. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. PMID: 35303432; PMCID: PMC9137452.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. In Vivo and Ex Vivo Experimental Approach for Studying Functional Role of Notch in Pulmonary Vascular Disease. Methods Mol Biol. 2022; 2472:209-220. Jain PP, Hosokawa S, Babicheva A, Zhao T, Chen J, Thistlethwaite PA, Makino A, Yuan JX. PMID: 35674903.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. TRPC6, a therapeutic target for pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1161-L1182. Jain PP, Lai N, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34704831; PMCID: PMC8715021.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C1010-C1027. Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 34669509; PMCID: PMC8714987.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. Iatrogenic intrathoracic encapsulated siliconoma from a ruptured breast implant. BMJ Case Rep. 2021 Sep 08; 14(9). Chopra CS, Thistlethwaite P, Herrera F, Suliman A. PMID: 34497056; PMCID: PMC8438724.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211041512. Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 34531976; PMCID: PMC8438952.
      View in: PubMed   Mentions: 4  
    14. Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19. Elife. 2021 08 13; 10. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar GD, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 34463615; PMCID: PMC8463074.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    15. Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells. Front Physiol. 2021; 12:714785. Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, Lai N, Zhao T, Hernandez M, Balistrieri A, Parmisano S, Simonson T, Breen E, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34408668; PMCID: PMC8364962.
      View in: PubMed   Mentions: 1  
    16. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 09; 178(17):3373-3394. Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19. bioRxiv. 2021 May 05. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar G, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 33106807; PMCID: PMC7587781.
      View in: PubMed   Mentions:
    18. The Anterior Mediastinal Mass-the Challenging Management of Hypoxemia Despite Peripheral Cannulation for ECMO. J Cardiothorac Vasc Anesth. 2021 10; 35(10):3108-3117. Juan IC, Poorsattar SP, Banks DA, O'Brien EO, Fernando RJ, Addis D, Augoustides JG, Shah RM, Thistlethwaite PA. PMID: 33865684.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Imaging of pulmonary hypertension in adults: a position paper from the Fleischner Society. Eur Respir J. 2021 01; 57(1). Remy-Jardin M, Ryerson CJ, Schiebler ML, Leung ANC, Wild JM, Hoeper MM, Alderson PO, Goodman LR, Mayo J, Haramati LB, Ohno Y, Thistlethwaite P, van Beek EJR, Knight SL, Lynch DA, Rubin GD, Humbert M. PMID: 33402372.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    20. Imaging of Pulmonary Hypertension in Adults: A Position Paper from the Fleischner Society. Radiology. 2021 03; 298(3):531-549. Remy-Jardin M, Ryerson CJ, Schiebler ML, Leung ANC, Wild JM, Hoeper MM, Alderson PO, Goodman LR, Mayo J, Haramati LB, Ohno Y, Thistlethwaite P, van Beek EJR, Knight SL, Lynch DA, Rubin GD, Humbert M. PMID: 33399507.
      View in: PubMed   Mentions: 13     Fields:    
    21. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020956592. Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. PMID: 33282184; PMCID: PMC7691930.
      View in: PubMed   Mentions: 6  
    22. Bleomycin-induced lung injury treated with venovenous extracorporeal membrane oxygenation (ECMO) and ultra-protective ventilator settings. BMJ Case Rep. 2020 Nov 23; 13(11). Odish MF, McGuire WC, Thistlethwaite P, Crotty Alexander LE. PMID: 33229479; PMCID: PMC7684647.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep; 10(3):2045894020948470. Wu K, Tang H, Lin R, Carr SG, Wang Z, Babicheva A, Ayon RJ, Jain PP, Xiong M, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Valdez-Jasso D, Simonson TS, Desai AA, Garcia JGN, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 33294172; PMCID: PMC7707860.
      View in: PubMed   Mentions: 9  
    24. MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. 2020 09 22; 142(12):1190-1204. Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, Lei Y, Chen S, Yin Q, Thistlethwaite PA, Wang J, Gong K, Yuan ZY, Yuan JX, Shyy JY. PMID: 32755395; PMCID: PMC7497891.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    25. Multifocal Calcifying Fibrous Tumor at Seven Intrathoracic Sites in One Patient. Ann Thorac Surg. 2021 02; 111(2):e85-e88. Hernandez M, Lin G, Zhang Y, Rajabnejad A, Balistrieri F, Thistlethwaite P. PMID: 32682754; PMCID: PMC9362959.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. The sparkle of creativity. J Thorac Cardiovasc Surg. 2020 Sep; 160(3):740-752. Thistlethwaite PA. PMID: 32800264; PMCID: PMC8865752.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels. Am J Physiol Cell Physiol. 2020 05 01; 318(5):C954-C968. Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX. PMID: 32186932; PMCID: PMC7294324.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L10-L26. Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX. PMID: 31553627; PMCID: PMC6985878.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    29. AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 08 15; 198(4):509-520. Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang HY, Zhang J, Zhang Y, Kang J, Moya EA, Huang HD, Powell FL, Chen Z, Thistlethwaite PA, Yuan ZY, Shyy JY. PMID: 29570986; PMCID: PMC6118028.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    30. Needle localization of small pulmonary nodules: Lessons learned. J Thorac Cardiovasc Surg. 2018 05; 155(5):2140-2147. Thistlethwaite PA, Gower JR, Hernandez M, Zhang Y, Picel AC, Roberts AC. PMID: 29455962.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    31. Linking Vascular Remodeling and Inflammation in Pulmonary Arterial Hypertension: Is There a Common Root Cause? Am J Respir Cell Mol Biol. 2017 07; 57(1):15-17. Thistlethwaite PA. PMID: 28665225; PMCID: PMC5516285.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    32. Staged Repair of an Aortic Pseudoaneurysm Secondary to Delayed Methylmethacrylate Plate Migration. Ann Thorac Surg. 2017 Feb; 103(2):e139-e141. Parker KL, Thistlethwaite P, Suliman AS, Reid C, Tenenhaus M, El Khoury Z, Golts EM. PMID: 28109373.
      View in: PubMed   Mentions:    Fields:    
    33. Multifocal Endobronchial Fibromas Presenting as Unilobar Emphysema. Ann Thorac Surg. 2015 Sep; 100(3):1109-11. Mumtaz S, Alkhuziem M, Chow J, Yen A, Lin G, Harrell JH, Thistlethwaite PA. PMID: 26354646.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. PMID: 25569851; PMCID: PMC4566064.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    35. Response to Letter Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". Circulation. 2015 Jul 14; 132(2):e17. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. PMID: 26169652; PMCID: PMC4624330.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    36. Invited commentary. Ann Thorac Surg. 2015 Mar; 99(3):1038-9. Thistlethwaite PA. PMID: 25742824.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease. Circulation. 2014 Sep 30; 130(14):1179-91. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. PMID: 25062690; PMCID: PMC4182129.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    38. Invited commentary. Ann Thorac Surg. 2014 Jun; 97(6):2025-6. Thistlethwaite PA. PMID: 24882285.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C871-8. Yamamura H, Yamamura A, Ko EA, Pohl NM, Smith KA, Zeifman A, Powell FL, Thistlethwaite PA, Yuan JX. PMID: 24573085; PMCID: PMC4010807.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    40. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA. PMID: 23527012; PMCID: PMC3604164.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    41. Invited commentary. Ann Thorac Surg. 2013 Mar; 95(3):1033-4. Thistlethwaite PA. PMID: 23438530.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    42. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol. 2012 Feb; 9(1):016005. Wendel M, Bazhenova L, Boshuizen R, Kolatkar A, Honnatti M, Cho EH, Marrinucci D, Sandhu A, Perricone A, Thistlethwaite P, Bethel K, Nieva J, Heuvel Mv, Kuhn P. PMID: 22307026; PMCID: PMC3387995.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCellsCTClinical Trials
    43. Unfavourable consequences of chronic cardiac HIF-1α stabilization. Cardiovasc Res. 2012 Apr 01; 94(1):77-86. Hölscher M, Schäfer K, Krull S, Farhat K, Hesse A, Silter M, Lin Y, Pichler BJ, Thistlethwaite P, El-Armouche A, Maier LS, Katschinski DM, Zieseniss A. PMID: 22258630.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    44. Invited commentary. Ann Thorac Surg. 2011 Apr; 91(4):1100. Thistlethwaite PA, Jamieson SW. PMID: 21440130.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Invited commentary. Ann Thorac Surg. 2011 Apr; 91(4):1213. Thistlethwaite PA. PMID: 21440147.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011 Apr 26; 123(16):1788-830. Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg N, Goldhaber SZ, Jenkins JS, Kline JA, Michaels AD, Thistlethwaite P, Vedantham S, White RJ, Zierler BK, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitatio, American Heart Association Council on Peripheral Vascular Disease, American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology. PMID: 21422387.
      View in: PubMed   Mentions: 554     Fields:    Translation:Humans
    47. Surgical management of endobronchial inflammatory myofibroblastic tumors. Ann Thorac Surg. 2011 Feb; 91(2):367-72. Thistlethwaite PA, Renner J, Duhamel D, Makani S, Lin GY, Jamieson SW, Harrell J. PMID: 21256271.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    48. Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2010 Nov 01; 182(9):1153-60. Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite PA, Tuder RM, Erzurum SC, Geraci MW, Coldren CD. PMID: 20581168; PMCID: PMC3001257.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    49. Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice. Am J Pathol. 2010 Jul; 177(1):97-105. Xue W, Cai L, Tan Y, Thistlethwaite P, Kang YJ, Li X, Feng W. PMID: 20566749; PMCID: PMC2893654.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    50. Invited commentary. Ann Thorac Surg. 2010 Mar; 89(3):835-6. Thistlethwaite P. PMID: 20172139.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    51. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation. 2010 Feb 09; 121(5):675-83. Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB. PMID: 20100968; PMCID: PMC2834271.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    52. Notch signaling in pulmonary hypertension. Adv Exp Med Biol. 2010; 661:279-98. Thistlethwaite PA, Li X, Zhang X. PMID: 20204737.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    53. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med. 2009 Nov; 15(11):1289-97. Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW, Thistlethwaite PA. PMID: 19855400; PMCID: PMC2780347.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    54. Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):179-91. Ressmeyer AR, Bai Y, Delmotte P, Uy KF, Thistlethwaite P, Fraire A, Sato O, Ikebe M, Sanderson MJ. PMID: 19767449; PMCID: PMC2937231.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    55. Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L666-76. Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite PA, Yuan JX. PMID: 19633069; PMCID: PMC2770792.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    56. Development and pathology of pulmonary hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S3-S9. Tuder RM, Abman SH, Braun T, Capron F, Stevens T, Thistlethwaite PA, Haworth SG. PMID: 19555856.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    57. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S20-S31. Morrell NW, Adnot S, Archer SL, Dupuis J, Lloyd Jones P, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. PMID: 19555855; PMCID: PMC2790324.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansAnimalsCells
    58. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009 May 05; 119(17):2313-22. Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX. PMID: 19380626; PMCID: PMC2749566.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    59. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L870-8. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX. PMID: 19286928; PMCID: PMC2692803.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    60. Utility of right ventricular Tei index in the noninvasive evaluation of chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. JACC Cardiovasc Imaging. 2009 Feb; 2(2):143-9. Blanchard DG, Malouf PJ, Gurudevan SV, Auger WR, Madani MM, Thistlethwaite P, Waltman TJ, Daniels LB, Raisinghani AB, DeMaria AN. PMID: 19356547.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    61. Airway stenoses after lung transplantation: incidence, management, and outcome. J Thorac Cardiovasc Surg. 2008 Dec; 136(6):1569-75. Thistlethwaite PA, Yung G, Kemp A, Osbourne S, Jamieson SW, Channick C, Harrell J. PMID: 19114208.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    62. Invited commentary. Ann Thorac Surg. 2008 Oct; 86(4):1320. Thistlethwaite PA. PMID: 18805184.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    63. Technique and outcomes of pulmonary endarterectomy surgery. Ann Thorac Cardiovasc Surg. 2008 Oct; 14(5):274-82. Thistlethwaite PA, Kaneko K, Madani MM, Jamieson SW. PMID: 18989242.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    64. Invited commentary. The apolipoprotein E epsilon4 allele. Ann Thorac Surg. 2008 Sep; 86(3):848. Thistlethwaite PA. PMID: 18721572.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    65. Endothelial expression of bone morphogenetic protein receptor type 1a is required for atrioventricular valve formation. Ann Thorac Surg. 2008 Jun; 85(6):2090-8. Kaneko K, Li X, Zhang X, Lamberti JJ, Jamieson SW, Thistlethwaite PA. PMID: 18498827.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    66. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. PMID: 17470567.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    67. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10. Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. PMID: 17189322.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    68. Venovenous extracorporeal life support after pulmonary endarterectomy: indications, techniques, and outcomes. Ann Thorac Surg. 2006 Dec; 82(6):2139-45. Thistlethwaite PA, Madani MM, Kemp AD, Hartley M, Auger WR, Jamieson SW. PMID: 17126125.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    69. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303. Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. PMID: 16980375.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    70. Lung cancer and radiofrequency ablation. J Vasc Interv Radiol. 2006 Jun; 17(6):927-51; quiz 951. Rose SC, Thistlethwaite PA, Sewell PE, Vance RB. PMID: 16778226.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    71. Outcomes of pulmonary endarterectomy for treatment of extreme thromboembolic pulmonary hypertension. J Thorac Cardiovasc Surg. 2006 Feb; 131(2):307-13. Thistlethwaite PA, Kemp A, Du L, Madani MM, Jamieson SW. PMID: 16434258.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    72. Outcomes of pulmonary endarterectomy surgery. Semin Thorac Cardiovasc Surg. 2006; 18(3):257-64. Thistlethwaite PA, Madani M, Jamieson SW. PMID: 17185189.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    73. Molecular biology of chronic thromboembolic pulmonary hypertension. Semin Thorac Cardiovasc Surg. 2006; 18(3):265-76. Sacks RS, Remillard CV, Agange N, Auger WR, Thistlethwaite PA, Yuan JX. PMID: 17185190.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    74. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol. 2005 Dec 06; 46(11):2116-24. Kido M, Du L, Sullivan CC, Li X, Deutsch R, Jamieson SW, Thistlethwaite PA. PMID: 16325051.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    75. Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension. Exp Lung Res. 2005 Oct; 31(8):783-806. Fantozzi I, Huang W, Zhang J, Zhang S, Platoshyn O, Remillard CV, Thistlethwaite PA, Yuan JX. PMID: 16368652; PMCID: PMC1409757.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    76. Breaking the barriers to global gene delivery. Nat Biotechnol. 2005 Mar; 23(3):305-6. Weitzman MD, Thistlethwaite PA. PMID: 15765082.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    77. Gene transfer of a TIE2 receptor antagonist prevents pulmonary hypertension in rodents. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):268-76. Kido M, Du L, Sullivan CC, Deutsch R, Jamieson SW, Thistlethwaite PA. PMID: 15678035.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    78. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13861-6. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. PMID: 15358862; PMCID: PMC518765.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansCells
    79. Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol Ther. 2004 Sep; 10(3):604-8. Du L, Kido M, Lee DV, Rabinowitz JE, Samulski RJ, Jamieson SW, Weitzman MD, Thistlethwaite PA. PMID: 15336660.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    80. Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1101-7. Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite PA, Rubin LJ, Yuan JX. PMID: 15317671.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    81. Molecular biology of primary pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):417-29, vi. Mandegar M, Thistlethwaite PA, Yuan JX. PMID: 15302361.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    82. Pulmonary thromboendarterectomy surgery. Cardiol Clin. 2004 Aug; 22(3):467-78, vii. Thistlethwaite PA, Madani M, Jamieson SW. PMID: 15302365.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    83. Pulmonary thromboendarterectomy. Ann Thorac Surg. 2004 Aug; 78(2):746-7. Thistlethwaite PA, Jamieson SW. PMID: 15309813.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    84. Dexmedetomidine and cardiac arrest. Anesthesiology. 2004 Mar; 100(3):738-9. Ingersoll-Weng E, Manecke GR, Thistlethwaite PA. PMID: 15108994.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    85. A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Ann Thorac Surg. 2004 Feb; 77(2):449-56; discussion 456-7. Chu D, Sullivan CC, Du L, Cho AJ, Kido M, Wolf PL, Weitzman MD, Jamieson SW, Thistlethwaite PA. PMID: 14759414.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    86. Gene delivery to the mammalian heart using AAV vectors. Methods Mol Biol. 2004; 246:213-24. Chu D, Thistlethwaite PA, Sullivan CC, Grifman MS, Weitzman MD. PMID: 14970595.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    87. Pulmonary endarterectomy: experience and lessons learned in 1,500 cases. Ann Thorac Surg. 2003 Nov; 76(5):1457-62; discussion 1462-4. Jamieson SW, Kapelanski DP, Sakakibara N, Manecke GR, Thistlethwaite PA, Kerr KM, Channick RN, Fedullo PF, Auger WR. PMID: 14602267.
      View in: PubMed   Mentions: 163     Fields:    Translation:Humans
    88. Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12331-6. Sullivan CC, Du L, Chu D, Cho AJ, Kido M, Wolf PL, Jamieson SW, Thistlethwaite PA. PMID: 14512515; PMCID: PMC218758.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    89. Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors. J Thorac Cardiovasc Surg. 2003 Sep; 126(3):671-9. Chu D, Sullivan CC, Weitzman MD, Du L, Wolf PL, Jamieson SW, Thistlethwaite PA. PMID: 14502138.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    90. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L740-54. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX. PMID: 12740218.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    91. Tricuspid valvular disease in the patient with chronic pulmonary thromboembolic disease. Curr Opin Cardiol. 2003 Mar; 18(2):111-6. Thistlethwaite PA, Jamieson SW. PMID: 12652215.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    92. Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med. 2003 Feb 06; 348(6):500-9. Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethwaite PA. PMID: 12571257.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    93. Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J Appl Physiol (1985). 2002 Apr; 92(4):1594-602. Sweeney M, McDaniel SS, Platoshyn O, Zhang S, Yu Y, Lapp BR, Zhao Y, Thistlethwaite PA, Yuan JX. PMID: 11896026.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    94. Human angiopoietin gene expression is a marker for severity of pulmonary hypertension in patients undergoing pulmonary thromboendarterectomy. J Thorac Cardiovasc Surg. 2001 Jul; 122(1):65-73. Thistlethwaite PA, Lee SH, Du LL, Wolf PL, Sullivan C, Pradhan S, Deutsch R, Jamieson SW. PMID: 11436038.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    95. Pulmonary thromboendarterectomy combined with other cardiac operations: indications, surgical approach, and outcome. Ann Thorac Surg. 2001 Jul; 72(1):13-7; discussion 17-9. Thistlethwaite PA, Auger WR, Madani MM, Pradhan S, Kapelanski DP, Jamieson SW. PMID: 11465167.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    96. Surgical management of congenital obstruction of the left main coronary artery with supravalvular aortic stenosis. J Thorac Cardiovasc Surg. 2000 Dec; 120(6):1040-6. Thistlethwaite PA, Madani MM, Kriett JM, Milhoan K, Jamieson SW. PMID: 11088024.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    97. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med. 2000 Mar 02; 342(9):626-33. Lee SH, Wolf PL, Escudero R, Deutsch R, Jamieson SW, Thistlethwaite PA. PMID: 10699162.
      View in: PubMed   Mentions: 193     Fields:    Translation:Humans
    98. Obliterative bronchiolitis: the Achilles heel of lung transplantation. Transplantation. 1999 Oct 15; 68(7):923-4. Thistlethwaite PA, Jamieson SW. PMID: 10532527.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    99. Ablation of persistent air leaks after thoracic procedures with fibrin sealant. Ann Thorac Surg. 1999 Feb; 67(2):575-7. Thistlethwaite PA, Luketich JD, Ferson PF, Keenan RJ, Jamieson SW. PMID: 10197706.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    100. Surgical management of spontaneous left main coronary artery dissection. Ann Thorac Surg. 1998 Jul; 66(1):258-60. Thistlethwaite PA, Tarazi RY, Giordano FJ, Jamieson SW. PMID: 9692481.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    101. Venous-right atrial bypass for superior vena cava thrombosis during orthotopic liver transplantation. Transplantation. 1997 Feb 15; 63(3):471-2. Pinna AD, Sugitani A, Thistlethwaite P, Kang Y, Marongiu L, Todo S, Starzl TE, Fung JJ. PMID: 9039942; PMCID: PMC2993323.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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