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    Patricia Thistlethwaite

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSurgery
    Address9300 Campus Point Drive #7892
    CA La Jolla 92037
    Phone858-657-7777
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      Collapse Overview 
      Collapse Overview
      Research

      Our lab focuses on understanding the molecular mechanism of pulmonary arterial hypertension and coronary vascular development. We are interested in how arteries and veins are specified and how vessels develop normal and pathologic smooth muscle cell investment.

      Research Topics

    • Angiogenesis

    • Cardiovascular Disease

    • Cell Biology

    • Development

    • Molecular Biology

    • Translational Research


    • Current Project Titles

    • The role of Notch3 signaling in pulmonary arterial hypertension

    • ERG-APJ signaling influences the development of pulmonary veno-occlusive disease in humans and mice

    • Molecular signals controlling coronary artery and venous development


    • Profile

      Dr. Patricia A. Thistlethwaite is a cardiothoracic surgeon and researcher who specializes in adult cardiac surgery and molecular biology. She performs the full range of cardiothoracic surgeries including heart and lung transplantation, coronary artery bypass surgery, valve repair and replacement, and general thoracic operations.

      Dr. Thistlethwaite is head of a molecular biology laboratory in the Division of Cardiothoracic Surgery. Her research focuses on molecular causes of pulmonary hypertension, mechanisms of coronary arterial and venous differentiation and angiogenesis, and the genetics of cardiac development. She leads a number of major investigations including several National Institutes of Health-funded studies and a Center for Medical Research and Education Fund (CMREF) project studying the causes, prevention, and treatment of pulmonary arterial hypertension.

      Dr. Thistlethwaite also collaborates with Dr. Jason Yuan of the Division of Pulmonary and Critical Care Medicine in the UC San Diego Department of Medicine in two NIH basic science studies, one on the genetic basis of idiopathic pulmonary arterial hypertension and one on the molecular biology of the lung. In addition, she collaborates with Dr. Paul Insel in the Department of Pharmacology in investigating caveolae expression in pulmonary vascular remodeling.

      As Program Director of the UC San Diego Cardiovascular and Thoracic Surgery Residency Program, Dr. Thistlethwaite is the first woman in the United States to be a cardiothoracic surgery program director. She was elected as a member of the American Association for Thoracic Surgery, the most prestigious society for cardiothoracic surgeons, in April 2006


      Collapse Research 
      Collapse Research Activities and Funding
      Small Molecule NOTCH Inhibitors for the treatment of pulmonary hypertension
      NIH/NHLBI R01HL132225Jun 1, 2016 - Mar 31, 2020
      Role: Principal Investigator
      NOTCH3 Signaling in Pulmonary Hypertension
      NIH/NHLBI R01HL119543Sep 1, 2014 - May 31, 2019
      Role: Principal Investigator
      Molecular Mechanisms of Pulmonary Hypertension
      NIH/NHLBI R01HL070852Jul 1, 2002 - Jun 30, 2013
      Role: Principal Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Thistlethwaite P. Linking Vascular Remodeling and Inflammation in Pulmonary Arterial Hypertension: Is There a Common Root Cause? Am J Respir Cell Mol Biol. 2017 Jul; 57(1):15-17. PMID: 28665225.
        View in: PubMed
      2. Parker KL, Thistlethwaite P, Suliman AS, Reid C, Tenenhaus M, El Khoury Z, Golts EM. Staged Repair of an Aortic Pseudoaneurysm Secondary to Delayed Methylmethacrylate Plate Migration. Ann Thorac Surg. 2017 Feb; 103(2):e139-e141. PMID: 28109373.
        View in: PubMed
      3. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite P, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. PMID: 25569851.
        View in: PubMed
      4. Mumtaz S, Alkhuziem M, Chow J, Yen A, Lin G, Harrell JH, Thistlethwaite P. Multifocal Endobronchial Fibromas Presenting as Unilobar Emphysema. Ann Thorac Surg. 2015 Sep; 100(3):1109-11. PMID: 26354646.
        View in: PubMed
      5. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite P. Response to Letter Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". Circulation. 2015 Jul 14; 132(2):e17. PMID: 26169652.
        View in: PubMed
      6. Thistlethwaite P. Invited commentary. Ann Thorac Surg. 2015 Mar; 99(3):1038-9. PMID: 25742824.
        View in: PubMed
      7. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite P. ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease. Circulation. 2014 Sep 30; 130(14):1179-91. PMID: 25062690.
        View in: PubMed
      8. Thistlethwaite P. Invited commentary. Ann Thorac Surg. 2014 Jun; 97(6):2025-6. PMID: 24882285.
        View in: PubMed
      9. Yamamura H, Yamamura A, Ko EA, Pohl NM, Smith KA, Zeifman A, Powell FL, Thistlethwaite P, Yuan JX. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May; 306(9):C871-8. PMID: 24573085.
        View in: PubMed
      10. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite P, Harismendy O, Carson DA, Frazer KA. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. PMID: 23527012.
        View in: PubMed
      11. Thistlethwaite P. Invited commentary. Ann Thorac Surg. 2013 Mar; 95(3):1033-4. PMID: 23438530.
        View in: PubMed
      12. Thistlethwaite P, Jamieson SW. Invited commentary. Ann Thorac Surg. 2011 Apr; 91(4):1100. PMID: 21440130.
        View in: PubMed
      13. Thistlethwaite P. Invited commentary. Ann Thorac Surg. 2011 Apr; 91(4):1213. PMID: 21440147.
        View in: PubMed
      14. Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg N, Goldhaber SZ, Jenkins JS, Kline JA, Michaels AD, Thistlethwaite P, Vedantham S, White RJ, Zierler BK. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011 Apr 26; 123(16):1788-830. PMID: 21422387.
        View in: PubMed
      15. Thistlethwaite P, Renner J, Duhamel D, Makani S, Lin GY, Jamieson SW, Harrell J. Surgical management of endobronchial inflammatory myofibroblastic tumors. Ann Thorac Surg. 2011 Feb; 91(2):367-72. PMID: 21256271.
        View in: PubMed
      16. Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite P, Tuder RM, Erzurum SC, Geraci MW, Coldren CD. Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2010 Nov 1; 182(9):1153-60. PMID: 20581168.
        View in: PubMed
      17. Thistlethwaite P. Invited commentary. Ann Thorac Surg. 2010 Mar; 89(3):835-6. PMID: 20172139.
        View in: PubMed
      18. Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite P, Sussman MA, Gottlieb RA, Gustafsson AB. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation. 2010 Feb 9; 121(5):675-83. PMID: 20100968.
        View in: PubMed
      19. Thistlethwaite P, Li X, Zhang X. Notch signaling in pulmonary hypertension. Adv Exp Med Biol. 2010; 661:279-98. PMID: 20204737.
        View in: PubMed
      20. Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW, Thistlethwaite P. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med. 2009 Nov; 15(11):1289-97. PMID: 19855400.
        View in: PubMed
      21. Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite P, Yuan JX. Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L666-76. PMID: 19633069.
        View in: PubMed
      22. Tuder RM, Abman SH, Braun T, Capron F, Stevens T, Thistlethwaite P, Haworth SG. Development and pathology of pulmonary hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S3-9. PMID: 19555856.
        View in: PubMed
      23. Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite P, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009 May 5; 119(17):2313-22. PMID: 19380626.
        View in: PubMed
      24. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite P, Jamieson SW, Rubin LJ, Yuan JX. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L870-8. PMID: 19286928.
        View in: PubMed
      25. Blanchard DG, Malouf PJ, Gurudevan SV, Auger WR, Madani MM, Thistlethwaite P, Waltman TJ, Daniels LB, Raisinghani AB, DeMaria AN. Utility of right ventricular Tei index in the noninvasive evaluation of chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. JACC Cardiovasc Imaging. 2009 Feb; 2(2):143-9. PMID: 19356547.
        View in: PubMed
      26. Thistlethwaite P, Yung G, Kemp A, Osbourne S, Jamieson SW, Channick C, Harrell J. Airway stenoses after lung transplantation: incidence, management, and outcome. J Thorac Cardiovasc Surg. 2008 Dec; 136(6):1569-75. PMID: 19114208.
        View in: PubMed
      27. Thistlethwaite P. Invited commentary. Ann Thorac Surg. 2008 Oct; 86(4):1320. PMID: 18805184.
        View in: PubMed
      28. Thistlethwaite P, Kaneko K, Madani MM, Jamieson SW. Technique and outcomes of pulmonary endarterectomy surgery. Ann Thorac Cardiovasc Surg. 2008 Oct; 14(5):274-82. PMID: 18989242.
        View in: PubMed
      29. Thistlethwaite P. Invited commentary. The apolipoprotein E epsilon4 allele. Ann Thorac Surg. 2008 Sep; 86(3):848. PMID: 18721572.
        View in: PubMed
      30. Kaneko K, Li X, Zhang X, Lamberti JJ, Jamieson SW, Thistlethwaite P. Endothelial expression of bone morphogenetic protein receptor type 1a is required for atrioventricular valve formation. Ann Thorac Surg. 2008 Jun; 85(6):2090-8. PMID: 18498827.
        View in: PubMed
      31. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite P, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. PMID: 17470567.
        View in: PubMed
      32. Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite P, Insel PA, Yuan JX. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10. PMID: 17189322.
        View in: PubMed
      33. Thistlethwaite P, Madani MM, Kemp AD, Hartley M, Auger WR, Jamieson SW. Venovenous extracorporeal life support after pulmonary endarterectomy: indications, techniques, and outcomes. Ann Thorac Surg. 2006 Dec; 82(6):2139-45. PMID: 17126125.
        View in: PubMed
      34. Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite P, Yuan JX, Insel PA. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303. PMID: 16980375.
        View in: PubMed
      35. Rose SC, Thistlethwaite P, Sewell PE, Vance RB. Lung cancer and radiofrequency ablation. J Vasc Interv Radiol. 2006 Jun; 17(6):927-51; quiz 951. PMID: 16778226.
        View in: PubMed
      36. Thistlethwaite P, Kemp A, Du L, Madani MM, Jamieson SW. Outcomes of pulmonary endarterectomy for treatment of extreme thromboembolic pulmonary hypertension. J Thorac Cardiovasc Surg. 2006 Feb; 131(2):307-13. PMID: 16434258.
        View in: PubMed
      37. Thistlethwaite P, Madani M, Jamieson SW. Outcomes of pulmonary endarterectomy surgery. Semin Thorac Cardiovasc Surg. 2006; 18(3):257-64. PMID: 17185189.
        View in: PubMed
      38. Sacks RS, Remillard CV, Agange N, Auger WR, Thistlethwaite P, Yuan JX. Molecular biology of chronic thromboembolic pulmonary hypertension. Semin Thorac Cardiovasc Surg. 2006; 18(3):265-76. PMID: 17185190.
        View in: PubMed
      39. Kido M, Du L, Sullivan CC, Li X, Deutsch R, Jamieson SW, Thistlethwaite P. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol. 2005 Dec 6; 46(11):2116-24. PMID: 16325051.
        View in: PubMed
      40. Kido M, Du L, Sullivan CC, Deutsch R, Jamieson SW, Thistlethwaite P. Gene transfer of a TIE2 receptor antagonist prevents pulmonary hypertension in rodents. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):268-76. PMID: 15678035.
        View in: PubMed
      41. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite P, Rubin LJ, Yuan JX. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13861-6. PMID: 15358862.
        View in: PubMed
      42. Du L, Kido M, Lee DV, Rabinowitz JE, Samulski RJ, Jamieson SW, Weitzman MD, Thistlethwaite P. Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol Ther. 2004 Sep; 10(3):604-8. PMID: 15336660.
        View in: PubMed
      43. Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite P, Rubin LJ, Yuan JX. Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1101-7. PMID: 15317671.
        View in: PubMed
      44. Mandegar M, Thistlethwaite P, Yuan JX. Molecular biology of primary pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):417-29, vi. PMID: 15302361.
        View in: PubMed
      45. Thistlethwaite P, Madani M, Jamieson SW. Pulmonary thromboendarterectomy surgery. Cardiol Clin. 2004 Aug; 22(3):467-78, vii. PMID: 15302365.
        View in: PubMed
      46. Thistlethwaite P, Jamieson SW. Pulmonary thromboendarterectomy. Ann Thorac Surg. 2004 Aug; 78(2):746-7. PMID: 15309813.
        View in: PubMed
      47. Ingersoll-Weng E, Manecke GR, Thistlethwaite P. Dexmedetomidine and cardiac arrest. Anesthesiology. 2004 Mar; 100(3):738-9. PMID: 15108994.
        View in: PubMed
      48. Chu D, Sullivan CC, Du L, Cho AJ, Kido M, Wolf PL, Weitzman MD, Jamieson SW, Thistlethwaite P. A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Ann Thorac Surg. 2004 Feb; 77(2):449-56; discussion 456-7. PMID: 14759414.
        View in: PubMed
      49. Chu D, Thistlethwaite P, Sullivan CC, Grifman MS, Weitzman MD. Gene delivery to the mammalian heart using AAV vectors. Methods Mol Biol. 2004; 246:213-24. PMID: 14970595.
        View in: PubMed
      50. Jamieson SW, Kapelanski DP, Sakakibara N, Manecke GR, Thistlethwaite P, Kerr KM, Channick RN, Fedullo PF, Auger WR. Pulmonary endarterectomy: experience and lessons learned in 1,500 cases. Ann Thorac Surg. 2003 Nov; 76(5):1457-62; discussion 1462-4. PMID: 14602267.
        View in: PubMed
      51. Sullivan CC, Du L, Chu D, Cho AJ, Kido M, Wolf PL, Jamieson SW, Thistlethwaite P. Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12331-6. PMID: 14512515.
        View in: PubMed
      52. Chu D, Sullivan CC, Weitzman MD, Du L, Wolf PL, Jamieson SW, Thistlethwaite P. Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors. J Thorac Cardiovasc Surg. 2003 Sep; 126(3):671-9. PMID: 14502138.
        View in: PubMed
      53. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite P, Kriett JM, Yung G, Rubin LJ, Yuan JX. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L740-54. PMID: 12740218.
        View in: PubMed
      54. Thistlethwaite P, Jamieson SW. Tricuspid valvular disease in the patient with chronic pulmonary thromboembolic disease. Curr Opin Cardiol. 2003 Mar; 18(2):111-6. PMID: 12652215.
        View in: PubMed
      55. Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethwaite P. Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med. 2003 Feb 6; 348(6):500-9. PMID: 12571257.
        View in: PubMed
      56. Thistlethwaite P, Mo M, Madani MM, Deutsch R, Blanchard D, Kapelanski DP, Jamieson SW. Operative classification of thromboembolic disease determines outcome after pulmonary endarterectomy. J Thorac Cardiovasc Surg. 2002 Dec; 124(6):1203-11. PMID: 12447188.
        View in: PubMed
      57. Sweeney M, McDaniel SS, Platoshyn O, Zhang S, Yu Y, Lapp BR, Zhao Y, Thistlethwaite P, Yuan JX. Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J Appl Physiol (1985). 2002 Apr; 92(4):1594-602. PMID: 11896026.
        View in: PubMed
      58. Tripathy U, Yung GL, Kriett JM, Thistlethwaite P, Kapelanski DP, Jamieson SW. Donor transfer of pulmonary coccidioidomycosis in lung transplantation. Ann Thorac Surg. 2002 Jan; 73(1):306-8. PMID: 11834038.
        View in: PubMed
      59. Thistlethwaite P, Lee SH, Du LL, Wolf PL, Sullivan C, Pradhan S, Deutsch R, Jamieson SW. Human angiopoietin gene expression is a marker for severity of pulmonary hypertension in patients undergoing pulmonary thromboendarterectomy. J Thorac Cardiovasc Surg. 2001 Jul; 122(1):65-73. PMID: 11436038.
        View in: PubMed
      60. Thistlethwaite P, Auger WR, Madani MM, Pradhan S, Kapelanski DP, Jamieson SW. Pulmonary thromboendarterectomy combined with other cardiac operations: indications, surgical approach, and outcome. Ann Thorac Surg. 2001 Jul; 72(1):13-7; discussion 17-9. PMID: 11465167.
        View in: PubMed
      61. Thistlethwaite P, Kriett JM, Madani MM, Jamieson SW. Acquired aortopulmonary fistula in acute dissection. J Thorac Cardiovasc Surg. 2001 Jun; 121(6):1213-5. PMID: 11385397.
        View in: PubMed
      62. Thistlethwaite P, Madani MM, Kriett JM, Milhoan K, Jamieson SW. Surgical management of congenital obstruction of the left main coronary artery with supravalvular aortic stenosis. J Thorac Cardiovasc Surg. 2000 Dec; 120(6):1040-6. PMID: 11088024.
        View in: PubMed
      63. Thistlethwaite P, Tarazi RY, Giordano FJ, Jamieson SW. Surgical management of spontaneous left main coronary artery dissection. Ann Thorac Surg. 1998 Jul; 66(1):258-60. PMID: 9692481.
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