Alan Saghatelian

Title(s)Adjunct Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An inner mitochondrial membrane microprotein from the SLC35A4 upstream ORF regulates cellular metabolism. J Mol Biol. 2024 Apr 03; 168559. Rocha AL, Pai V, Perkins G, Chang T, Ma J, Chu Q, Vaughan JM, Diedrich JK, Ellisman MH, Saghatelian A. PMID: 38580077.
      View in: PubMed   Mentions:    Fields:    
    2. Urocortin3 contributes to paracrine inhibition of islet alpha cells in mice. J Endocrinol. 2024 Apr 01. Noguchi GM, Castillo VC, Donaldson CJ, Flisher MR, Momen AT, Saghatelian A, Huising MO. PMID: 38593829.
      View in: PubMed   Mentions:
    3. A fast-acting lipid checkpoint in G1 prevents mitotic defects. Nat Commun. 2024 Mar 18; 15(1):2441. Köberlin MS, Fan Y, Liu C, Chung M, Pinto AFM, Jackson PK, Saghatelian A, Meyer T. PMID: 38499565; PMCID: PMC10948896.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids. bioRxiv. 2023 Nov 16. Riecan M, Domanska V, Lupu C, Patel M, Vondrackova M, Rossmeisl M, Saghatelian A, Lupu F, Kuda O. PMID: 38014093; PMCID: PMC10680750.
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    5. Biochemistry and Protein Interactions of the CYREN Microprotein. Biochemistry. 2023 11 07; 62(21):3050-3060. Xie L, Bowman ME, Louie GV, Zhang C, Ardejani MS, Huang X, Chu Q, Donaldson CJ, Vaughan JM, Shan H, Powers ET, Kelly JW, Lyumkis D, Noel JP, Saghatelian A. PMID: 37813856.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. The Integration of Proteogenomics and Ribosome Profiling Circumvents Key Limitations to Increase the Coverage and Confidence of Novel Microproteins. bioRxiv. 2023 Oct 02. de Souza EV, Bookout AL, Barnes CA, Miller B, Machado P, Basso LA, Bizarro CV, Saghatelian A. PMID: 37808637; PMCID: PMC10557729.
      View in: PubMed   Mentions:
    7. Proteomic discovery of chemical probes that perturb protein complexes in human cells. Mol Cell. 2023 05 18; 83(10):1725-1742.e12. Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. PMID: 37084731; PMCID: PMC10198961.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 Apr; 28(4):1827. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36658336.
      View in: PubMed   Mentions:    Fields:    
    9. The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma. Nat Commun. 2023 03 10; 14(1):1328. Morgado-Palacin L, Brown JA, Martinez TF, Garcia-Pedrero JM, Forouhar F, Quinn SA, Reglero C, Vaughan J, Heydary YH, Donaldson C, Rodriguez-Perales S, Allonca E, Granda-Diaz R, Fernandez AF, Fraga MF, Kim AL, Santos-Juanes J, Owens DM, Rodrigo JP, Saghatelian A, Ferrando AA. PMID: 36899004; PMCID: PMC10006087.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Profiling mouse brown and white adipocytes to identify metabolically relevant small ORFs and functional microproteins. Cell Metab. 2023 01 03; 35(1):166-183.e11. Martinez TF, Lyons-Abbott S, Bookout AL, De Souza EV, Donaldson C, Vaughan JM, Lau C, Abramov A, Baquero AF, Baquero K, Friedrich D, Huard J, Davis R, Kim B, Koch T, Mercer AJ, Misquith A, Murray SA, Perry S, Pino LK, Sanford C, Simon A, Zhang Y, Zipp G, Bizarro CV, Shokhirev MN, Whittle AJ, Searle BC, MacCoss MJ, Saghatelian A, Barnes CA. PMID: 36599300; PMCID: PMC9889109.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. A class of anti-inflammatory lipids decrease with aging in the central nervous system. Nat Chem Biol. 2023 02; 19(2):187-197. Tan D, Konduri S, Erikci Ertunc M, Zhang P, Wang J, Chang T, Pinto AFM, Rocha A, Donaldson CJ, Vaughan JM, Ludwig RG, Willey E, Iyer M, Gray PC, Maher P, Allen NJ, Zuchero JB, Dillin A, Mori MA, Kohama SG, Siegel D, Saghatelian A. PMID: 36266352; PMCID: PMC9898107.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 04; 28(4):1813-1826. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative*. PMID: 36127429; PMCID: PMC10027624.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    13. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature. 2022 09; 609(7928):846-853. Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. PMID: 35940205; PMCID: PMC9678024.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    14. Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes. Cell. 2022 08 18; 185(17):3263-3277.e15. Russell BJ, Brown SD, Siguenza N, Mai I, Saran AR, Lingaraju A, Maissy ES, Dantas Machado AC, Pinto AFM, Sanchez C, Rossitto LA, Miyamoto Y, Richter RA, Ho SB, Eckmann L, Hasty J, Gonzalez DJ, Saghatelian A, Knight R, Zarrinpar A. PMID: 35931082; PMCID: PMC9464905.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    15. Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. Cell Rep. 2022 07 05; 40(1):111008. Dantas Machado AC, Brown SD, Lingaraju A, Sivaganesh V, Martino C, Chaix A, Zhao P, Pinto AFM, Chang MW, Richter RA, Saghatelian A, Saltiel AR, Knight R, Panda S, Zarrinpar A. PMID: 35793637; PMCID: PMC9296000.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    16. Standardized annotation of translated open reading frames. Nat Biotechnol. 2022 07; 40(7):994-999. Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S. PMID: 35831657; PMCID: PMC9757701.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    17. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature. 2022 06; 606(7916):968-975. Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson AT, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn BB. PMID: 35676490; PMCID: PMC9242854.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    18. µProteInS-a proteogenomics pipeline for finding novel bacterial microproteins encoded by small ORFs. Bioinformatics. 2022 04 28; 38(9):2612-2614. de Souza EV, Dalberto PF, Machado VP, Canedo A, Saghatelian A, Machado P, Basso LA, Bizarro CV. PMID: 35188179.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    19. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 02 22; 7(4). Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. PMID: 35015730; PMCID: PMC8876453.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. FGF1 and insulin control lipolysis by convergent pathways. Cell Metab. 2022 01 04; 34(1):171-183.e6. Sancar G, Liu S, Gasser E, Alvarez JG, Moutos C, Kim K, van Zutphen T, Wang Y, Huddy TF, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM. PMID: 34986332; PMCID: PMC8863067.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    21. Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs). J Lipid Res. 2021; 62:100108. Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A, Kahn BB. PMID: 34418413; PMCID: PMC8479484.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 08 02; 220(8). Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. PMID: 34132745; PMCID: PMC8240855.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    23. A short ORF-encoded transcriptional regulator. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Koh M, Ahmad I, Ko Y, Zhang Y, Martinez TF, Diedrich JK, Chu Q, Moresco JJ, Erb MA, Saghatelian A, Schultz PG, Bollong MJ. PMID: 33468658; PMCID: PMC7848545.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    24. Elovl2 Is Required for Robust Visual Function in Zebrafish. Cells. 2020 12 02; 9(12). Dasyani M, Gao F, Xu Q, Van Fossan D, Zhang E, F M Pinto A, Saghatelian A, Skowronska-Krawczyk D, Chao DL. PMID: 33276584; PMCID: PMC7761535.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. J Cell Biol. 2020 10 05; 219(10). Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV. PMID: 32915949; PMCID: PMC7659722.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. Networking in Circulation: Lipoproteins, PM20D1, and N-acyl Amino Acid Bioactivity. Cell Chem Biol. 2020 09 17; 27(9):1112-1113. Saghatelian A. PMID: 32946756.
      View in: PubMed   Mentions: 1     Fields:    
    27. Serine restriction alters sphingolipid diversity to constrain tumour growth. Nature. 2020 10; 586(7831):790-795. Muthusamy T, Cordes T, Handzlik MK, You L, Lim EW, Gengatharan J, Pinto AFM, Badur MG, Kolar MJ, Wallace M, Saghatelian A, Metallo CM. PMID: 32788725; PMCID: PMC7606299.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    28. Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis. Nat Biotechnol. 2020 11; 38(11):1288-1297. Chen PB, Black AS, Sobel AL, Zhao Y, Mukherjee P, Molparia B, Moore NE, Aleman Muench GR, Wu J, Chen W, Pinto AFM, Maryanoff BE, Saghatelian A, Soroosh P, Torkamani A, Leman LJ, Ghadiri MR. PMID: 32541956; PMCID: PMC7641989.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    29. Antioxidant Effects of N-Acetylcysteine Prevent Programmed Metabolic Disease in Mice. Diabetes. 2020 08; 69(8):1650-1661. Charron MJ, Williams L, Seki Y, Du XQ, Chaurasia B, Saghatelian A, Summers SA, Katz EB, Vuguin PM, Reznik SE. PMID: 32444367; PMCID: PMC7372077.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    30. Insights into GLP-1 Receptor Activation with a Nonpeptide Agonist. Biochemistry. 2020 04 28; 59(16):1549-1550. Martinez TF, Vaughan J, Saghatelian A. PMID: 32297516.
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    31. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. J Biol Chem. 2020 05 01; 295(18):5891-5905. Erikci Ertunc M, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AFM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, Saghatelian A. PMID: 32152231; PMCID: PMC7196635.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    32. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. Aging Cell. 2020 02; 19(2):e13100. Chen D, Chao DL, Rocha L, Kolar M, Nguyen Huu VA, Krawczyk M, Dasyani M, Wang T, Jafari M, Jabari M, Ross KD, Saghatelian A, Hamilton BA, Zhang K, Skowronska-Krawczyk D. PMID: 31943697; PMCID: PMC6996962.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    33. Accurate annotation of human protein-coding small open reading frames. Nat Chem Biol. 2020 04; 16(4):458-468. Martinez TF, Chu Q, Donaldson C, Tan D, Shokhirev MN, Saghatelian A. PMID: 31819274; PMCID: PMC7085969.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    34. Regulation of the ER stress response by a mitochondrial microprotein. Nat Commun. 2019 10 25; 10(1):4883. Chu Q, Martinez TF, Novak SW, Donaldson CJ, Tan D, Vaughan JM, Chang T, Diedrich JK, Andrade L, Kim A, Zhang T, Manor U, Saghatelian A. PMID: 31653868; PMCID: PMC6814811.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    35. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J Clin Invest. 2019 10 01; 129(10):4138-4150. Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB. PMID: 31449056; PMCID: PMC6763232.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    36. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Org Lett. 2019 10 04; 21(19):8080-8084. Wang H, Kolar MJ, Chang T, Rizo J, Konduri S, McNerlin C, Saghatelian A, Siegel D. PMID: 31545060.
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    37. PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice. J Clin Invest. 2019 08 05; 129(9):3717-3731. Syed I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. PMID: 31380811; PMCID: PMC6715391.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    38. Substrate-Selective Enzyme Inhibitors. Trends Pharmacol Sci. 2019 10; 40(10):716-718. Chu Q, Chang T, Saghatelian A. PMID: 31383375.
      View in: PubMed   Mentions: 2     Fields:    
    39. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. J Biol Chem. 2019 07 05; 294(27):10698-10707. Kolar MJ, Konduri S, Chang T, Wang H, McNerlin C, Ohlsson L, Härröd M, Siegel D, Saghatelian A. PMID: 31152059; PMCID: PMC6615670.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    40. Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation. J Am Chem Soc. 2019 06 05; 141(22):8798-8806. Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A. PMID: 31056915; PMCID: PMC6662584.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    41. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. J Antibiot (Tokyo). 2019 06; 72(6):498-506. Wang H, Chang T, Konduri S, Huang J, Saghatelian A, Siegel D. PMID: 30988370; PMCID: PMC6784544.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. Genes Dev. 2019 04 01; 33(7-8):418-435. Choi SH, Martinez TF, Kim S, Donaldson C, Shokhirev MN, Saghatelian A, Jones KA. PMID: 30819820; PMCID: PMC6446539.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    43. A Hidden ORF Reveals an Immune Protector. Biochemistry. 2019 02 26; 58(8):1022-1023. Chu Q, Saghatelian A. PMID: 30724555; PMCID: PMC6443401.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    44. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Rep. 2019 01 02; 26(1):192-208.e6. Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. PMID: 30605676; PMCID: PMC6344045.
      View in: PubMed   Mentions: 108     Fields:    Translation:Animals
    45. Small, but mighty? Searching for human microproteins and their potential for understanding health and disease. Expert Rev Proteomics. 2018 12; 15(12):963-965. Rathore A, Martinez TF, Chu Q, Saghatelian A. PMID: 30415582; PMCID: PMC6497149.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    46. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 10 02; 28(4):543-546. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. PMID: 30244974; PMCID: PMC6542592.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    47. MIEF1 Microprotein Regulates Mitochondrial Translation. Biochemistry. 2018 09 25; 57(38):5564-5575. Rathore A, Chu Q, Tan D, Martinez TF, Donaldson CJ, Diedrich JK, Yates JR, Saghatelian A. PMID: 30215512; PMCID: PMC6443411.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    48. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun. 2018 07 20; 9(1):2872. Zarrinpar A, Chaix A, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S. PMID: 30030441; PMCID: PMC6054678.
      View in: PubMed   Mentions: 183     Fields:    Translation:Animals
    49. Author Correction: Blocking Zika virus vertical transmission. Sci Rep. 2018 Jun 05; 8(1):8794. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. PMID: 29867187; PMCID: PMC5986756.
      View in: PubMed   Mentions: 3     Fields:    
    50. The influence of transcript assembly on the proteogenomics discovery of microproteins. PLoS One. 2018; 13(3):e0194518. Ma J, Saghatelian A, Shokhirev MN. PMID: 29584760; PMCID: PMC5870951.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    51. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem. 2018 04 17; 90(8):5358-5365. Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A. PMID: 29578702; PMCID: PMC5962352.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    52. How many human proteoforms are there? Nat Chem Biol. 2018 02 14; 14(3):206-214. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. PMID: 29443976; PMCID: PMC5837046.
      View in: PubMed   Mentions: 289     Fields:    Translation:HumansCells
    53. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 02 06; 27(2):419-427.e4. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. PMID: 29414687; PMCID: PMC5807007.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    54. The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis. J Biol Chem. 2018 03 16; 293(11):4071-4084. Muñoz SS, Li H, Ruberu K, Chu Q, Saghatelian A, Ooi L, Garner B. PMID: 29414786; PMCID: PMC5857987.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    55. Blocking Zika virus vertical transmission. Sci Rep. 2018 01 19; 8(1):1218. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. PMID: 29352135; PMCID: PMC5775359.
      View in: PubMed   Mentions: 24     Fields:    
    56. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018 01 18; 553(7688):351-355. Sulli G, Rommel A, Wang X, Kolar MJ, Puca F, Saghatelian A, Plikus MV, Verma IM, Panda S. PMID: 29320480; PMCID: PMC5924733.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    57. Novel Biology and Druggable Targets via Chemoproteomics. Biochemistry. 2017 12 19; 56(50):6515-6516. Saghatelian A. PMID: 29214804.
      View in: PubMed   Mentions:    Fields:    
    58. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796; PMCID: PMC5718507.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    59. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24; 21(4):1021-1035. Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. PMID: 29069585; PMCID: PMC5771491.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    60. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Nature. 2017 09 20; 549(7673):548-552. Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. PMID: 28959974; PMCID: PMC5624508.
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    61. Identification of Microprotein-Protein Interactions via APEX Tagging. Biochemistry. 2017 07 05; 56(26):3299-3306. Chu Q, Rathore A, Diedrich JK, Donaldson CJ, Yates JR, Saghatelian A. PMID: 28589727; PMCID: PMC5499098.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    62. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. PMID: 28350171; PMCID: PMC5568760.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    63. Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. Endocrinology. 2017 03 01; 158(3):477-489. Krzeszinski JY, Schwaid AG, Cheng WY, Jin Z, Gallegos ZR, Saghatelian A, Wan Y. PMID: 27967239; PMCID: PMC5460780.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    64. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 02 27; 7:43515. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. PMID: 28240264; PMCID: PMC5327486.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    65. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metab. 2017 02 07; 25(2):463-471. Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. PMID: 28089566; PMCID: PMC5299044.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    66. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):580-585. Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y. PMID: 28049847; PMCID: PMC5255630.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    67. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 2017 02 07; 25(2):412-427. Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. PMID: 28041958; PMCID: PMC5568699.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    68. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature. 2017 01 12; 541(7636):228-232. Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP. PMID: 28024296.
      View in: PubMed   Mentions: 260     Fields:    Translation:HumansAnimalsCells
    69. A human microprotein that interacts with the mRNA decapping complex. Nat Chem Biol. 2017 02; 13(2):174-180. D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. PMID: 27918561; PMCID: PMC5247292.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    70. Glucagon and Thyroid Hormone: A Championship Team. Cell. 2016 Oct 20; 167(3):604-605. Saghatelian A, Cravatt B. PMID: 27768884.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    71. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 10; 22(10):1108-1119. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. PMID: 27643638; PMCID: PMC5053891.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    72. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217. Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. PMID: 27573241; PMCID: PMC5064000.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    73. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 08 23; 55(33):4636-41. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. PMID: 27509211; PMCID: PMC5056623.
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    74. Revealing disease-associated pathways by network integration of untargeted metabolomics. Nat Methods. 2016 09; 13(9):770-6. Pirhaji L, Milani P, Leidl M, Curran T, Avila-Pacheco J, Clish CB, White FM, Saghatelian A, Fraenkel E. PMID: 27479327; PMCID: PMC5209295.
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    75. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. J Am Chem Soc. 2016 08 03; 138(30):9473-8. Chu Q, Diedrich JK, Vaughan JM, Donaldson CJ, Nunn MF, Lee KF, Saghatelian A. PMID: 27379525; PMCID: PMC5063305.
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    76. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes. 2016 07; 65(7):1808-15. Moraes-Vieira PM, Saghatelian A, Kahn BB. PMID: 27288004; PMCID: PMC4915575.
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    77. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May; 12(5):367-372. Parsons WH, Kolar MJ, Kamat SS, Cognetta AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. PMID: 27018888; PMCID: PMC4837090.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    78. Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. Anal Chem. 2016 Apr 05; 88(7):3967-75. Ma J, Diedrich JK, Jungreis I, Donaldson C, Vaughan J, Kellis M, Yates JR, Saghatelian A. PMID: 27010111; PMCID: PMC4939623.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    79. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. PMID: 26985573; PMCID: PMC4797065.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    80. Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects. Cell Metab. 2016 Mar 08; 23(3):479-91. Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, Saghatelian A, Wan Y. PMID: 26777690; PMCID: PMC4785078.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    81. Editorial overview: Omics: The maturation of chemical biology. Curr Opin Chem Biol. 2016 Feb; 30:v-vi. Saghatelian A, Nomura DK, Weerapana E. PMID: 26739665.
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    82. Discovery and characterization of smORF-encoded bioactive polypeptides. Nat Chem Biol. 2015 Dec; 11(12):909-16. Saghatelian A, Couso JP. PMID: 26575237; PMCID: PMC4956473.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimals
    83. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93. Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH. PMID: 26496605.
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    84. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. J Lipid Res. 2015 Aug; 56(8):1501-10. Zhang T, Barclay L, Walensky LD, Saghatelian A. PMID: 26059977; PMCID: PMC4513991.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    85. Defining the metabolome: size, flux, and regulation. Mol Cell. 2015 May 21; 58(4):699-706. Zamboni N, Saghatelian A, Patti GJ. PMID: 26000853; PMCID: PMC4831058.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    86. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. PMID: 25945737; PMCID: PMC5278765.
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    87. Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG). Biotechnol Prog. 2015 May-Jun; 31(3):840-8. Kim KJ, Kim YW, Kim YG, Park HM, Jin JM, Hwan Kim Y, Yang YH, Kyu Lee J, Chung J, Lee SG, Saghatelian A. PMID: 25832445.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    88. Identification and characterization of sORF-encoded polypeptides. Crit Rev Biochem Mol Biol. 2015 Mar-Apr; 50(2):134-41. Chu Q, Ma J, Saghatelian A. PMID: 25857697; PMCID: PMC4761265.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    89. A nonapoptotic role for BAX and BAK in eicosanoid metabolism. ACS Chem Biol. 2015 Jun 19; 10(6):1398-403. Zhang T, Walensky LD, Saghatelian A. PMID: 25815636; PMCID: PMC4599777.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    90. Maternal adiponectin controls milk composition to prevent neonatal inflammation. Endocrinology. 2015 Apr; 156(4):1504-13. Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A, Wan Y. PMID: 25590242; PMCID: PMC4399311.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    91. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. PMID: 25496053.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    92. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. PMID: 25303528; PMCID: PMC4260972.
      View in: PubMed   Mentions: 334     Fields:    Translation:HumansAnimalsCells
    93. A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. J Am Chem Soc. 2014 Sep 17; 136(37):12848-51. Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, Gellman SH. PMID: 25191938; PMCID: PMC4183665.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    94. Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer. Mol Cell Proteomics. 2014 Nov; 13(11):3082-96. Nazarian A, Lawlor K, Yi SS, Philip J, Ghosh M, Yaneva M, Villanueva J, Saghatelian A, Assel M, Vickers AJ, Eastham JA, Scher HI, Carver BS, Lilja H, Tempst P. PMID: 25056937; PMCID: PMC4223493.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    95. Localization of anionic phospholipids in Escherichia coli cells. J Bacteriol. 2014 Oct; 196(19):3386-98. Oliver PM, Crooks JA, Leidl M, Yoon EJ, Saghatelian A, Weibel DB. PMID: 25002539; PMCID: PMC4187673.
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    96. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 2014 Jul 03; 511(7507):94-8. Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. PMID: 24847884; PMCID: PMC4142213.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    97. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. PMID: 24828042; PMCID: PMC4263271.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansAnimalsCells
    98. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. J Biol Chem. 2014 Apr 18; 289(16):10950-10957. Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A. PMID: 24610814; PMCID: PMC4036235.
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    99. Deletion of PREPl causes growth impairment and hypotonia in mice. PLoS One. 2014; 9(2):e89160. Lone AM, Leidl M, McFedries AK, Horner JW, Creemers J, Saghatelian A. PMID: 24586561; PMCID: PMC3938459.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    100. Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. J Proteome Res. 2014 Mar 07; 13(3):1757-65. Ma J, Ward CC, Jungreis I, Slavoff SA, Schwaid AG, Neveu J, Budnik BA, Kellis M, Saghatelian A. PMID: 24490786; PMCID: PMC3993966.
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    101. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science. 2014 Feb 14; 343(6172):1248636. Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF. PMID: 24407481; PMCID: PMC4107353.
      View in: PubMed   Mentions: 264     Fields:    Translation:AnimalsCells
    102. Chemoproteomic discovery of cysteine-containing human short open reading frames. J Am Chem Soc. 2013 Nov 13; 135(45):16750-3. Schwaid AG, Shannon DA, Ma J, Slavoff SA, Levin JZ, Weerapana E, Saghatelian A. PMID: 24152191; PMCID: PMC3868496.
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    103. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. PMID: 24153306; PMCID: PMC4141623.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    104. MAIT recognition of a stimulatory bacterial antigen bound to MR1. J Immunol. 2013 Nov 15; 191(10):5268-77. López-Sagaseta J, Dulberger CL, McFedries A, Cushman M, Saghatelian A, Adams EJ. PMID: 24108697; PMCID: PMC3819123.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    105. Analysis of the proteolysis of bioactive peptides using a peptidomics approach. Nat Protoc. 2013 Sep; 8(9):1730-42. Kim YG, Lone AM, Saghatelian A. PMID: 23949379; PMCID: PMC4170687.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    106. Proteolysis controls endogenous substance P levels. PLoS One. 2013; 8(7):e68638. Mitchell AJ, Lone AM, Tinoco AD, Saghatelian A. PMID: 23894327; PMCID: PMC3716696.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    107. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1788-94. Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. PMID: 23723371; PMCID: PMC3794714.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    108. Methods for the elucidation of protein-small molecule interactions. Chem Biol. 2013 May 23; 20(5):667-73. McFedries A, Schwaid A, Saghatelian A. PMID: 23706633.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    109. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. PMID: 23685806; PMCID: PMC3759823.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    110. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1771-8. López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. PMID: 23613577; PMCID: PMC3651419.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    111. Emerging roles of lipids in BCL-2 family-regulated apoptosis. Biochim Biophys Acta. 2013 Oct; 1831(10):1542-54. Zhang T, Saghatelian A. PMID: 23524027.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    112. Peptidomics methods for the identification of peptidase-substrate interactions. Curr Opin Chem Biol. 2013 Feb; 17(1):83-9. Lone AM, Kim YG, Saghatelian A. PMID: 23332665; PMCID: PMC3594040.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    113. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. PLoS Pathog. 2013 Jan; 9(1):e1003101. Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM. PMID: 23300454; PMCID: PMC3536714.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    114. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nat Chem Biol. 2013 Jan; 9(1):59-64. Slavoff SA, Mitchell AJ, Schwaid AG, Cabili MN, Ma J, Levin JZ, Karger AD, Budnik BA, Rinn JL, Saghatelian A. PMID: 23160002; PMCID: PMC3625679.
      View in: PubMed   Mentions: 293     Fields:    Translation:Humans
    115. Discovering ligand-receptor interactions. Nat Biotechnol. 2012 Oct; 30(10):959-61. Slavoff SA, Saghatelian A. PMID: 23051814.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    116. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes Dev. 2012 Jun 15; 26(12):1306-11. Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y. PMID: 22713870; PMCID: PMC3387658.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    117. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8523-7. Kim YG, Lone AM, Nolte WM, Saghatelian A. PMID: 22586115; PMCID: PMC3365226.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    118. Cytotoxicity of a Ti(IV) compound is independent of serum proteins. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5016-21. Tinoco AD, Thomas HR, Incarvito CD, Saghatelian A, Valentine AM. PMID: 22411801; PMCID: PMC3323991.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    119. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1637-42. Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. PMID: 22307623; PMCID: PMC3277167.
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    120. Functional analysis of protein targets by metabolomic approaches. Top Curr Chem. 2012; 324:137-62. Kim YG, Saghatelian A. PMID: 22083210.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    121. Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nat Commun. 2012; 3:1008. Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y. PMID: 22910354; PMCID: PMC3520613.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    122. Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. J Am Chem Soc. 2011 Nov 02; 133(43):17168-71. Vinayavekhin N, Saghatelian A. PMID: 21973308; PMCID: PMC4569094.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    123. Investigating endogenous peptides and peptidases using peptidomics. Biochemistry. 2011 Sep 06; 50(35):7447-61. Tinoco AD, Saghatelian A. PMID: 21786763; PMCID: PMC3418817.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    124. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J Am Chem Soc. 2011 Aug 03; 133(30):11665-74. Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. PMID: 21692504; PMCID: PMC3145007.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    125. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. PLoS One. 2011; 6(7):e21209. Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. PMID: 21750705; PMCID: PMC3130023.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    126. Monoalkylglycerol ether lipids promote adipogenesis. J Am Chem Soc. 2011 Apr 13; 133(14):5178-81. Homan EA, Kim YG, Cardia JP, Saghatelian A. PMID: 21428285; PMCID: PMC4761264.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    127. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry. 2011 Mar 29; 50(12):2213-22. Tinoco AD, Kim YG, Tagore DM, Wiwczar J, Lane WS, Danial NN, Saghatelian A. PMID: 21299233; PMCID: PMC3076939.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    128. A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands. Mol Biosyst. 2011 Apr; 7(4):1046-9. Kim YG, Lou AC, Saghatelian A. PMID: 21283866.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    129. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010 Dec 14; 33(6):853-62. Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ. PMID: 21167756; PMCID: PMC3010391.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    130. Peptidomics of the prolyl peptidases. AAPS J. 2010 Dec; 12(4):483-91. Lone AM, Nolte WM, Tinoco AD, Saghatelian A. PMID: 20552307; PMCID: PMC2976987.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    131. Untargeted metabolomics. Curr Protoc Mol Biol. 2010 Apr; Chapter 30:Unit 30.1.1-24. Vinayavekhin N, Saghatelian A. PMID: 20373502.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    132. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. J Am Chem Soc. 2010 Mar 24; 132(11):3819-30. Tinoco AD, Tagore DM, Saghatelian A. PMID: 20178363; PMCID: PMC2842575.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    133. Exploring disease through metabolomics. ACS Chem Biol. 2010 Jan 15; 5(1):91-103. Vinayavekhin N, Homan EA, Saghatelian A. PMID: 20020774.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    134. Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry. 2009 Dec 22; 48(50):11971-81. Nolte WM, Tagore DM, Lane WS, Saghatelian A. PMID: 19911840; PMCID: PMC2813186.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    135. The promise and challenge of '-omic' approaches. Curr Opin Chem Biol. 2009 Dec; 13(5-6):501-2. MacBeath G, Saghatelian A. PMID: 19853495.
      View in: PubMed   Mentions: 2     Fields:    
    136. Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa. ACS Chem Biol. 2009 Aug 21; 4(8):617-23. Vinayavekhin N, Saghatelian A. PMID: 19621937.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    137. Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. J Am Chem Soc. 2009 Apr 15; 131(14):5030-1. Rodgers MA, Saghatelian A, Yang PL. PMID: 19301856; PMCID: PMC4166558.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    138. Peptidase substrates via global peptide profiling. Nat Chem Biol. 2009 Jan; 5(1):23-5. Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. PMID: 19011639; PMCID: PMC2730040.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    139. A global metabolite profiling approach to identify protein-metabolite interactions. J Am Chem Soc. 2008 Oct 29; 130(43):14111-3. Tagore R, Thomas HR, Homan EA, Munawar A, Saghatelian A. PMID: 18831549.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    140. Sequence-addressable DNA logic. Small. 2008 Apr; 4(4):427-31. Voelcker NH, Guckian KM, Saghatelian A, Ghadiri MR. PMID: 18350554.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    141. Identification of protein pheromones that promote aggressive behaviour. Nature. 2007 Dec 06; 450(7171):899-902. Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF, Stowers L. PMID: 18064011.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansAnimalsCells
    142. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev. 2007 Aug 01; 21(15):1895-908. Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. PMID: 17652179; PMCID: PMC1935028.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    143. Assessing enzyme activities using stable isotope labeling and mass spectrometry. Mol Cell Proteomics. 2007 Oct; 6(10):1771-7. Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. PMID: 17627935.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    144. A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chem Biol. 2007 Mar; 14(3):257-67. Ostash B, Saghatelian A, Walker S. PMID: 17379141; PMCID: PMC1936435.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    145. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol. 2006 Oct; 13(10):1041-50. Chiang KP, Niessen S, Saghatelian A, Cravatt BF. PMID: 17052608.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    146. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. 2006 Aug 01; 45(30):9007-15. Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF. PMID: 16866345.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    147. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 2006 Apr 18; 45(15):4720-6. Leung D, Saghatelian A, Simon GM, Cravatt BF. PMID: 16605240; PMCID: PMC1538545.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    148. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol. 2005 Oct; 23(10):1303-7. Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. PMID: 16200062.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    149. Discovery metabolite profiling--forging functional connections between the proteome and metabolome. Life Sci. 2005 Aug 19; 77(14):1759-66. Saghatelian A, Cravatt BF. PMID: 15964030.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    150. Assignment of protein function in the postgenomic era. Nat Chem Biol. 2005 Aug; 1(3):130-42. Saghatelian A, Cravatt BF. PMID: 16408016.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    151. Desorption/ionization on silicon nanowires. Anal Chem. 2005 Mar 15; 77(6):1641-6. Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, Sahi V, Dubrow R, Cravatt BF, Vertes A, Siuzdak G. PMID: 15762567.
      View in: PubMed   Mentions: 36     Fields:    
    152. Global strategies to integrate the proteome and metabolome. Curr Opin Chem Biol. 2005 Feb; 9(1):62-8. Saghatelian A, Cravatt BF. PMID: 15701455.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    153. Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry. 2004 Nov 16; 43(45):14332-9. Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, Cravatt BF. PMID: 15533037.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    154. Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10821-6. Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH. PMID: 15247426; PMCID: PMC490018.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    155. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther. 2004 Nov; 311(2):441-8. Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. PMID: 15229230.
      View in: PubMed   Mentions: 135     Fields:    Translation:Animals
    156. Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10000-5. Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. PMID: 15220480; PMCID: PMC454150.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    157. Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl. 2004 Jun 07; 43(23):3063-7. Sánchez-Quesada J, Saghatelian A, Cheley S, Bayley H, Ghadiri MR. PMID: 15188482; PMCID: PMC1866269.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    158. DNA detection and signal amplification via an engineered allosteric enzyme. J Am Chem Soc. 2003 Jan 15; 125(2):344-5. Saghatelian A, Guckian KM, Thayer DA, Ghadiri MR. PMID: 12517141; PMCID: PMC2453066.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    159. DNA-based photonic logic gates: AND, NAND, and INHIBIT. J Am Chem Soc. 2003 Jan 15; 125(2):346-7. Saghatelian A, Völcker NH, Guckian KM, Lin VS, Ghadiri MR. PMID: 12517142.
      View in: PubMed   Mentions: 23     Fields:    
    160. Total synthesis of the calphostins: application of fischer carbene complexes and thermodynamic control of atropisomers. J Org Chem. 2001 Feb 23; 66(4):1297-309. Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A, Mammen J. PMID: 11312960.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    161. A chiroselective peptide replicator. Nature. 2001 Feb 15; 409(6822):797-801. Saghatelian A, Yokobayashi Y, Soltani K, Ghadiri MR. PMID: 11236988.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    162. Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins. J Am Chem Soc. 2000 Apr 05; 122(13):3224-3225. Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A. PMID: 23335811; PMCID: PMC3548573.
      View in: PubMed   Mentions: 7     Fields:    
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