Mary Lewinski

Title(s)Associate Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, San Diego, CAFellowship06/2013Infectious Diseases
    University of California, San Diego, San Diego, CAInternship / Residency06/2010Internal Medicine
    University of California, San Diego, La Jolla, CAM.D.06/2008Medicine
    University of California, San Diego, La Jolla, CAPh.D.09/2005Biomedical Sciences
    University of Southern California, Los Angeles, CAB.A. / B.A.05/2000Philosophy / Political Science

    Collapse Research 
    Collapse Research Activities and Funding
    RNA-based PROTACs Targeting HIV-1
    NIH/NIAID R03AI172489Aug 1, 2022 - Jul 31, 2024
    Role: Principal Investigator
    HIV-1 Modulation of the Ubiquitinome and Its Effects on Cell-to-Cell Transmission
    NIH K08AI112394Jan 1, 2015 - Dec 31, 2020
    Role: Principal Investigator
    Center for AIDS Research
    NIH P30AI036214Apr 1, 1994 - Mar 31, 2023
    Role: Director, Developmental Core

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HIV-1 latency is established preferentially in minimally activated and non-dividing cells during productive infection of primary CD4 T cells. PLoS One. 2022; 17(7):e0271674. Soto PC, Terry VH, Lewinski MK, Deshmukh S, Beliakova-Bethell N, Spina CA. PMID: 35895672; PMCID: PMC9328514.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    2. Comparative Analysis of T-Cell Spatial Proteomics and the Influence of HIV Expression. Mol Cell Proteomics. 2022 03; 21(3):100194. Oom AL, Stoneham CA, Lewinski MK, Richards A, Wozniak JM, Shams-Ud-Doha K, Gonzalez DJ, Krogan NJ, Guatelli J. PMID: 35017099; PMCID: PMC8956815.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity. PLoS Pathog. 2021 05; 17(5):e1009519. Park SH, Siddiqi H, Castro DV, De Angelis AA, Oom AL, Stoneham CA, Lewinski MK, Clark AE, Croker BA, Carlin AF, Guatelli J, Opella SJ. PMID: 34003853; PMCID: PMC8184013.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    4. Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell. 2021 06 17; 81(12):2656-2668.e8. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. PMID: 33930332; PMCID: PMC8043580.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    5. Functional Landscape of SARS-CoV-2 Cellular Restriction. bioRxiv. 2020 Sep 30. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Pratt D, Churas C, Rosenthal SB, Liu S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Oom AL, Miorin L, Rodriguez-Frandsen A, Urbanowski M, Shaw ML, Chang MW, Benner C, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. PMID: 33024967; PMCID: PMC7536870.
      View in: PubMed   Mentions:
    6. The C-Terminal End of HIV-1 Vpu Has a Clade-Specific Determinant That Antagonizes BST-2 and Facilitates Virion Release. J Virol. 2019 06 01; 93(11). Sharma S, Jafari M, Bangar A, William K, Guatelli J, Lewinski MK. PMID: 30867310; PMCID: PMC6532089.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. An N-Glycosylated Form of SERINC5 Is Specifically Incorporated into HIV-1 Virions. J Virol. 2018 11 15; 92(22). Sharma S, Lewinski MK, Guatelli J. PMID: 30158294; PMCID: PMC6206478.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    8. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. PMID: 28527342; PMCID: PMC5654527.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    9. Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr. Mol Cell Proteomics. 2017 08; 16(8):1447-1461. Lapek JD, Lewinski MK, Wozniak JM, Guatelli J, Gonzalez DJ. PMID: 28606917; PMCID: PMC5546197.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    10. Non-degradative Ubiquitination of Protein Kinases. PLoS Comput Biol. 2016 06; 12(6):e1004898. Ball KA, Johnson JR, Lewinski MK, Guatelli J, Verschueren E, Krogan NJ, Jacobson MP. PMID: 27253329; PMCID: PMC4890936.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    11. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015 Dec 16; 90(5):2486-502. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. PMID: 26676780; PMCID: PMC4810708.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly. J Biol Chem. 2015 Apr 24; 290(17):10919-33. Lewinski MK, Jafari M, Zhang H, Opella SJ, Guatelli J. PMID: 25759385; PMCID: PMC4409254.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    13. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife. 2014 Apr 29; 3:e02362. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J, Xiong Y. PMID: 24843023; PMCID: PMC4018625.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    14. Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release. J Virol. 2014 May; 88(9):5062-78. Jafari M, Guatelli J, Lewinski MK. PMID: 24574397; PMCID: PMC3993827.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    15. HIV latency and integration site placement in five cell-based models. Retrovirology. 2013 Aug 16; 10:90. Sherrill-Mix S, Lewinski MK, Famiglietti M, Bosque A, Malani N, Ocwieja KE, Berry CC, Looney D, Shan L, Agosto LM, Pace MJ, Siliciano RF, O'Doherty U, Guatelli J, Planelles V, Bushman FD. PMID: 23953889; PMCID: PMC3765678.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    16. Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog. 2006 Jun; 2(6):e60. Lewinski MK, Yamashita M, Emerman M, Ciuffi A, Marshall H, Crawford G, Collins F, Shinn P, Leipzig J, Hannenhalli S, Berry CC, Ecker JR, Bushman FD. PMID: 16789841; PMCID: PMC1480600.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansCells
    17. Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol. 2005 Nov; 3(11):848-58. Bushman F, Lewinski M, Ciuffi A, Barr S, Leipzig J, Hannenhalli S, Hoffmann C. PMID: 16175173.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    18. Molecular mechanisms of HIV-1 proviral latency. Expert Rev Anti Infect Ther. 2005 Oct; 3(5):805-14. Bisgrove D, Lewinski M, Bushman F, Verdin E. PMID: 16207172.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    19. Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol. 2005 Jun; 79(11):6610-9. Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, Hannenhalli S, Verdin E, Berry CC, Ecker JR, Bushman FD. PMID: 15890899; PMCID: PMC1112149.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    20. Retroviral DNA integration--mechanism and consequences. Adv Genet. 2005; 55:147-81. Lewinski MK, Bushman FD. PMID: 16291214.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
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