Theo Kirkland

Title(s)Senate Emeritus, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-7908-7302 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, Philadelphia, PAB.A.6/1/72Biology
    University of Alabama at Birmingham School of Medicine, Birmingham, ALM.D.6/1/75Medicine
    University of California, San Diego, San Diego, CA6/1/77Internal Medicine
    NIH, Bethesda, MD6/1/79Immunology Research
    University of California, San Diego, San Diego, CA6/1/80Chief Medical Resident
    University of California, San Diego, San Diego, CA6/1/82Infectious Diseases

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    NIH P01AI037232Jan 1, 1995 - Jul 31, 2005
    Role: Principal Investigator

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Coccidioides Species: A Review of Basic Research: 2022. J Fungi (Basel). 2022 Aug 16; 8(8). Kirkland TN, Stevens DA, Hung CY, Beyhan S, Taylor JW, Shubitz LF, Duttke SH, Heidari A, Johnson RH, Deresinski SC, Lauer A, Fierer J. PMID: 36012847; PMCID: PMC9409882.
      View in: PubMed   Mentions:
    2. Decoding Transcription Regulatory Mechanisms Associated with Coccidioides immitis Phase Transition Using Total RNA. mSystems. 2022 Feb 22; 7(1):e0140421. Duttke SH, Beyhan S, Singh R, Neal S, Viriyakosol S, Fierer J, Kirkland TN, Stajich JE, Benner C, Carlin AF. PMID: 35076277; PMCID: PMC8788335.
      View in: PubMed   Mentions:
    3. Transcriptional Analysis of Coccidioides immitis Mycelia and Spherules by RNA Sequencing. J Fungi (Basel). 2021 May 07; 7(5). Carlin AF, Beyhan S, Peña JF, Stajich JE, Viriyakosol S, Fierer J, Kirkland TN. PMID: 34067070; PMCID: PMC8150946.
      View in: PubMed   Mentions: 1  
    4. Innate Immune Receptors and Defense Against Primary Pathogenic Fungi. Vaccines (Basel). 2020 Jun 13; 8(2). Kirkland TN, Fierer J. PMID: 32545735; PMCID: PMC7350247.
      View in: PubMed   Mentions: 5  
    5. Special Issue: Genomic Data in Pathogenic Fungi. J Fungi (Basel). 2018 Mar 20; 4(1). Kirkland TN. PMID: 29558447; PMCID: PMC5872343.
      View in: PubMed   Mentions:
    6. Analysis of Transposable Elements in Coccidioides Species. J Fungi (Basel). 2018 Jan 19; 4(1). Kirkland TN, Muszewska A, Stajich JE. PMID: 29371508; PMCID: PMC5872316.
      View in: PubMed   Mentions: 7  
    7. Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity. Virulence. 2018; 9(1):1426-1435. Kirkland TN, Fierer J. PMID: 30179067; PMCID: PMC6141143.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    8. The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas. J Fungi (Basel). 2016 Dec 16; 2(4). Kirkland TN. PMID: 29376949; PMCID: PMC5715932.
      View in: PubMed   Mentions: 16  
    9. A few shared up-regulated genes may influence conidia to yeast transformation in dimorphic fungal pathogens. Med Mycol. 2016 Aug 01; 54(6):648-53. Kirkland TN. PMID: 27118798.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature. BMC Microbiol. 2013 May 28; 13:121. Viriyakosol S, Singhania A, Fierer J, Goldberg J, Kirkland TN, Woelk CH. PMID: 23714098; PMCID: PMC3693894.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    11. Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection. BMC Microbiol. 2012 Sep 24; 12:218. Woelk CH, Zhang JX, Walls L, Viriyakosol S, Singhania A, Kirkland TN, Fierer J. PMID: 23006927; PMCID: PMC3528620.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    12. The role of reactive oxygen intermediates in experimental coccidioidomycois in mice. BMC Microbiol. 2011 Apr 11; 11:71. Margolis DA, Viriyakosol S, Fierer J, Kirkland TN. PMID: 21481258; PMCID: PMC3088889.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    13. Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control. Genome Res. 2010 Jul; 20(7):938-46. Neafsey DE, Barker BM, Sharpton TJ, Stajich JE, Park DJ, Whiston E, Hung CY, McMahan C, White J, Sykes S, Heiman D, Young S, Zeng Q, Abouelleil A, Aftuck L, Bessette D, Brown A, FitzGerald M, Lui A, Macdonald JP, Priest M, Orbach MJ, Galgiani JN, Kirkland TN, Cole GT, Birren BW, Henn MR, Taylor JW, Rounsley SD. PMID: 20516208; PMCID: PMC2892095.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    14. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J Antibiot (Tokyo). 2010 Jan; 63(1):37-9. Asolkar RN, Kirkland TN, Jensen PR, Fenical W. PMID: 19927167; PMCID: PMC2825372.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    15. Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives. Genome Res. 2009 Oct; 19(10):1722-31. Sharpton TJ, Stajich JE, Rounsley SD, Gardner MJ, Wortman JR, Jordar VS, Maiti R, Kodira CD, Neafsey DE, Zeng Q, Hung CY, McMahan C, Muszewska A, Grynberg M, Mandel MA, Kellner EM, Barker BM, Galgiani JN, Orbach MJ, Kirkland TN, Cole GT, Henn MR, Birren BW, Taylor JW. PMID: 19717792; PMCID: PMC2765278.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimals
    16. Characterization of monoclonal antibodies to human soluble MD-2 protein. Hybridoma (Larchmt). 2006 Dec; 25(6):349-57. Viriyakosol S, McCray PB, Ashbaugh ME, Chu J, Jia HP, Weiss J, Kirkland TN. PMID: 17203997.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein. Vaccine. 2006 Jul 26; 24(31-32):5904-11. Shubitz LF, Yu JJ, Hung CY, Kirkland TN, Peng T, Perrill R, Simons J, Xue J, Herr RA, Cole GT, Galgiani JN. PMID: 16759762.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    18. Mutational analysis of membrane and soluble forms of human MD-2. J Biol Chem. 2006 Apr 28; 281(17):11955-64. Viriyakosol S, Tobias PS, Kirkland TN. PMID: 16467306.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006 Feb; 74(2):887-95. Viriyakosol S, Matthias MA, Swancutt MA, Kirkland TN, Vinetz JM. PMID: 16428731; PMCID: PMC1360355.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    20. Molecular and cellular mechanisms of protective immunity to coccidioidomycosis. Vaccine. 2006 Jan 23; 24(4):495-500. Kirkland TN, Raz E, Datta SK. PMID: 16181709.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    21. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun. 2005 Mar; 73(3):1553-60. Viriyakosol S, Fierer J, Brown GD, Kirkland TN. PMID: 15731053; PMCID: PMC1064940.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    22. Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS. J Biol Chem. 2003 Aug 01; 278(31):28367-71. Thompson PA, Tobias PS, Viriyakosol S, Kirkland TN, Kitchens RL. PMID: 12754215.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    23. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003 Jan 17; 278(3):1561-8. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. PMID: 12424240.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    24. Questioning CDC's "select agent" criteria. Science. 2002 Jan 04; 295(5552):43. Fierer J, Kirkland T. PMID: 11780643.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    25. Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice. Infect Immun. 1998 Aug; 66(8):3519-22. Kirkland TN, Finley F, Orsborn KI, Galgiani JN. PMID: 9673228; PMCID: PMC108381.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    26. Immunogenicity of a 48-kilodalton recombinant T-cell-reactive protein of Coccidioides immitis. Infect Immun. 1998 Feb; 66(2):424-31. Kirkland TN, Thomas PW, Finley F, Cole GT. PMID: 9453590; PMCID: PMC107922.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    27. Coccidioidomycosis: a reemerging infectious disease. Emerg Infect Dis. 1996 Jul-Sep; 2(3):192-9. Kirkland TN, Fierer J. PMID: 8903229; PMCID: PMC2626789.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsPHPublic Health
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