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Theo Kirkland

TitleSenate Emeritus
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0711
La Jolla CA 92093
Phone858-752-7989
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    MOLECULAR STRATEGIES TOWARDS A COCCIDIOIDOMYCOSIS VACCIN
    NIH/NIAID P01AI037232Jan 1, 1995 - Jul 31, 2005
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kirkland TN. Special Issue: Genomic Data in Pathogenic Fungi. J Fungi (Basel). 2018 Mar 20; 4(1). PMID: 29558447.
      View in: PubMed
    2. Kirkland TN, Muszewska A, Stajich JE. Analysis of Transposable Elements in Coccidioides Species. J Fungi (Basel). 2018 Jan 19; 4(1). PMID: 29371508.
      View in: PubMed
    3. Kirkland TN, Fierer J. Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity. Virulence. 2018; 9(1):1426-1435. PMID: 30179067.
      View in: PubMed
    4. Kirkland TN. The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas. J Fungi (Basel). 2016 Dec 16; 2(4). PMID: 29376949.
      View in: PubMed
    5. Kirkland TN. A few shared up-regulated genes may influence conidia to yeast transformation in dimorphic fungal pathogens. Med Mycol. 2016 Aug 01; 54(6):648-53. PMID: 27118798.
      View in: PubMed
    6. Viriyakosol S, Singhania A, Fierer J, Goldberg J, Kirkland TN, Woelk CH. Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature. BMC Microbiol. 2013 May 28; 13:121. PMID: 23714098; PMCID: PMC3693894.
    7. Woelk CH, Zhang JX, Walls L, Viriyakosol S, Singhania A, Kirkland TN, Fierer J. Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection. BMC Microbiol. 2012 Sep 24; 12:218. PMID: 23006927; PMCID: PMC3528620.
    8. Margolis DA, Viriyakosol S, Fierer J, Kirkland TN. The role of reactive oxygen intermediates in experimental coccidioidomycois in mice. BMC Microbiol. 2011 Apr 11; 11:71. PMID: 21481258; PMCID: PMC3088889.
    9. Neafsey DE, Barker BM, Sharpton TJ, Stajich JE, Park DJ, Whiston E, Hung CY, McMahan C, White J, Sykes S, Heiman D, Young S, Zeng Q, Abouelleil A, Aftuck L, Bessette D, Brown A, FitzGerald M, Lui A, Macdonald JP, Priest M, Orbach MJ, Galgiani JN, Kirkland TN, Cole GT, Birren BW, Henn MR, Taylor JW, Rounsley SD. Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control. Genome Res. 2010 Jul; 20(7):938-46. PMID: 20516208; PMCID: PMC2892095.
    10. Asolkar RN, Kirkland TN, Jensen PR, Fenical W. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J Antibiot (Tokyo). 2010 Jan; 63(1):37-9. PMID: 19927167; PMCID: PMC2825372.
    11. Sharpton TJ, Stajich JE, Rounsley SD, Gardner MJ, Wortman JR, Jordar VS, Maiti R, Kodira CD, Neafsey DE, Zeng Q, Hung CY, McMahan C, Muszewska A, Grynberg M, Mandel MA, Kellner EM, Barker BM, Galgiani JN, Orbach MJ, Kirkland TN, Cole GT, Henn MR, Birren BW, Taylor JW. Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives. Genome Res. 2009 Oct; 19(10):1722-31. PMID: 19717792; PMCID: PMC2765278.
    12. Viriyakosol S, McCray PB, Ashbaugh ME, Chu J, Jia HP, Weiss J, Kirkland TN. Characterization of monoclonal antibodies to human soluble MD-2 protein. Hybridoma (Larchmt). 2006 Dec; 25(6):349-57. PMID: 17203997.
      View in: PubMed
    13. Shubitz LF, Yu JJ, Hung CY, Kirkland TN, Peng T, Perrill R, Simons J, Xue J, Herr RA, Cole GT, Galgiani JN. Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein. Vaccine. 2006 Jul 26; 24(31-32):5904-11. PMID: 16759762.
      View in: PubMed
    14. Viriyakosol S, Tobias PS, Kirkland TN. Mutational analysis of membrane and soluble forms of human MD-2. J Biol Chem. 2006 Apr 28; 281(17):11955-64. PMID: 16467306.
      View in: PubMed
    15. Viriyakosol S, Matthias MA, Swancutt MA, Kirkland TN, Vinetz JM. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006 Feb; 74(2):887-95. PMID: 16428731; PMCID: PMC1360355.
    16. Kirkland TN, Raz E, Datta SK. Molecular and cellular mechanisms of protective immunity to coccidioidomycosis. Vaccine. 2006 Jan 23; 24(4):495-500. PMID: 16181709.
      View in: PubMed
    17. Viriyakosol S, Fierer J, Brown GD, Kirkland TN. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun. 2005 Mar; 73(3):1553-60. PMID: 15731053.
      View in: PubMed
    18. Thompson PA, Tobias PS, Viriyakosol S, Kirkland TN, Kitchens RL. Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS. J Biol Chem. 2003 Aug 01; 278(31):28367-71. PMID: 12754215.
      View in: PubMed
    19. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003 Jan 17; 278(3):1561-8. PMID: 12424240.
      View in: PubMed
    20. Fierer J, Kirkland T. Questioning CDC's "select agent" criteria. Science. 2002 Jan 04; 295(5552):43. PMID: 11780643.
      View in: PubMed
    21. Kirkland TN, Finley F, Orsborn KI, Galgiani JN. Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice. Infect Immun. 1998 Aug; 66(8):3519-22. PMID: 9673228; PMCID: PMC108381.
    22. Kirkland TN, Thomas PW, Finley F, Cole GT. Immunogenicity of a 48-kilodalton recombinant T-cell-reactive protein of Coccidioides immitis. Infect Immun. 1998 Feb; 66(2):424-31. PMID: 9453590; PMCID: PMC107922.
    23. Kirkland TN, Fierer J. Coccidioidomycosis: a reemerging infectious disease. Emerg Infect Dis. 1996 Jul-Sep; 2(3):192-9. PMID: 8903229; PMCID: PMC2626789.