Valentina Kouznetsova

Title(s)Emeritus Professor, CACSE
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Machine Learning and Functional Analysis of Placental DNA Methylation Signatures for Early-Onset Preeclampsia. Reprod Sci. 2026 Sep 10. Sharda R, Kouznetsova VL, Tsigelny IF. PMID: 42722973.
      View in: PubMed   Mentions:
    2. An AI-Assisted Workflow for Rapid Prioritization of FDA-Approved Drugs as HDAC3 Inhibitor Candidates for Drug Repurposing. Biology (Basel). 2026 Sep 08; 15(18). Kunimoto A, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 42792516.
      View in: PubMed   Mentions:
    3. Comparative Screening of Alzheimer's Disease, Lewy Body Dementia, and Frontotemporal Dementia Using miRNA and Machine Learning. Int J Neural Syst. 2027 Jan; 37(1):2750002. Luo B, Kouznetsova VL, Tsigelny IF. PMID: 42502242.
      View in: PubMed   Mentions:    Fields:    
    4. Metabolomics-Based Machine Learning Diagnostics of Post-Acute Sequelae of SARS-CoV-2 Infection. Metabolites. 2025 Dec 17; 15(12). Cai E, Kouznetsova VL, Tsigelny IF. PMID: 41441042; PMCID: PMC12734907.
      View in: PubMed   Mentions:
    5. Correction: Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern. PLoS Pathog. 2025 Nov; 21(11):e1013707. Almanza G, Clark AE, Kouznetsova V, Olmedillas E, Castro A, Tsigelny IF, Wu Y, Gao GF, Leibel SL, Bray W, Saphire EO, Carlin AF, Zanetti M. PMID: 41289198; PMCID: PMC12646426.
      View in: PubMed   Mentions:    Fields:    
    6. Epigenetic Regulation of OLIG2 in Glioblastoma: Mechanisms and Therapeutic Targets to Combat Treatment Resistance. J Mol Neurosci. 2025 Aug 31; 75(3):112. Kapoor S, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 40885881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Repurposing FDA-approved drugs for treatment of amyotrophic lateral sclerosis using machine learning. Amyotroph Lateral Scler Frontotemporal Degener. 2026 02; 27(1-2):198-206. Dogra S, Kouznetsova VL, Tsigelny IF. PMID: 40745959.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Electroencephalography-based diagnosis of schizophrenia using machine learning. Cereb Cortex. 2025 07 01; 35(7). Chien F, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 40650634.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Developing a novel medulloblastoma diagnostic with miRNA biomarkers and machine learning. Childs Nerv Syst. 2025 06 30; 41(1):221. Wang C, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 40583092.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. miRNA-Based Diagnosis of Schizophrenia Using Machine Learning. Int J Mol Sci. 2025 Mar 04; 26(5). Heda V, Dogra S, Kouznetsova VL, Kumar A, Kesari S, Tsigelny IF. PMID: 40076899; PMCID: PMC11900116.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Selective diagnostics of Amyotrophic Lateral Sclerosis, Alzheimer's and Parkinson's Diseases with machine learning and miRNA. Metab Brain Dis. 2025 01 02; 40(1):79. Lee J, Kouznetsova VL, Kesari S, Tsigelny I. PMID: 39747792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. miRNA in Machine-Learning-Based Diagnostics of Oral Cancer. Biomedicines. 2024 Oct 21; 12(10). Li X, Kouznetsova VL, Tsigelny IF. PMID: 39457716; PMCID: PMC11504892.
      View in: PubMed   Mentions: 1  
    13. Development of a Diagnostic Model for Pancreatic Ductal Adenocarcinoma Using Machine Learning and Blood-Based miRNAs. Oncology. 2025; 103(3):209-218. Tang JY, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 39231457.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Fibrin drives thromboinflammation and neuropathology in COVID-19. Nature. 2024 09; 633(8031):905-913. Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K. PMID: 39198643; PMCID: PMC11424477.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    15. Using Machine Learning and miRNA for the Diagnosis of Esophageal Cancer. J Appl Lab Med. 2024 07 01; 9(4):684-695. Aravind VA, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 38721901.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Colorectal Cancer Detection via Metabolites and Machine Learning. Curr Issues Mol Biol. 2024 Apr 30; 46(5):4133-4146. Yang R, Tsigelny IF, Kesari S, Kouznetsova VL. PMID: 38785522; PMCID: PMC11119033.
      View in: PubMed   Mentions: 4     Fields:    
    17. Laryngeal cancer diagnosis via miRNA-based decision tree model. Eur Arch Otorhinolaryngol. 2024 Mar; 281(3):1391-1399. Arora A, Tsigelny IF, Kouznetsova VL. PMID: 38147113.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Small molecular decoys in Alzheimer's disease. Neural Regen Res. 2024 Aug 01; 19(8):1658-1659. Oasa S, Kouznetsova VL, Tsigelny IF, Terenius L. PMID: 38103228; PMCID: PMC10960305.
      View in: PubMed   Mentions:
    19. Synergism in actions of HBV with aflatoxin in cancer development. Toxicology. 2023 11; 499:153652. Jin J, Kouznetsova VL, Kesari S, Tsigelny IF. PMID: 37858775.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern. PLoS Pathog. 2022 07; 18(7):e1010686. Almanza G, Clark AE, Kouznetsova V, Olmedillas E, Castro A, Tsigelny IF, Wu Y, Gao GF, Leibel SL, Bray W, Ollmann Saphire EO, Carlin AF, Zanetti M. PMID: 35862442; PMCID: PMC9302722.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Deep-learning- and pharmacophore-based prediction of RAGE inhibitors. Phys Biol. 2020 03 16; 17(3):036003. Huang DZ, Kouznetsova VL, Tsigelny IF. PMID: 31905346.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly. J Biol Chem. 2019 09 27; 294(39):14454-14466. Hayward D, Kouznetsova VL, Pierson HE, Hasan NM, Guzman ER, Tsigelny IF, Lutsenko S. PMID: 31337707; PMCID: PMC6768640.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    23. Recognition of early and late stages of bladder cancer using metabolites and machine learning. Metabolomics. 2019 06 20; 15(7):94. Kouznetsova VL, Kim E, Romm EL, Zhu A, Tsigelny IF. PMID: 31222577.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    24. Polycomb repressive 2 complex-Molecular mechanisms of function. Protein Sci. 2019 08; 28(8):1387-1399. Kouznetsova VL, Tchekanov A, Li X, Yan X, Tsigelny IF. PMID: 31095801; PMCID: PMC6635771.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    25. Cripto stabilizes GRP78 on the cell membrane. Protein Sci. 2018 03; 27(3):653-661. Kouznetsova VL, Hu H, Teigen K, Zanetti M, Tsigelny IF. PMID: 29226519; PMCID: PMC5818753.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma. J Transl Med. 2017 10 18; 15(1):210. Yenugonda V, Nomura N, Kouznetsova V, Tsigelny I, Fogal V, Nurmemmedov E, Kesari S, Babic I. PMID: 29047383; PMCID: PMC5648515.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    27. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384. Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. PMID: 26517684; PMCID: PMC5410230.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481; PMCID: PMC5840882.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    29. Molecular mechanisms of OLIG2 transcription factor in brain cancer. Oncotarget. 2016 Aug 16; 7(33):53074-53101. Tsigelny IF, Kouznetsova VL, Lian N, Kesari S. PMID: 27447975; PMCID: PMC5288170.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma. Mol Biosyst. 2015 Apr; 11(4):1012-28. Tsigelny IF, Kouznetsova VL, Jiang P, Pingle SC, Kesari S. PMID: 25648506.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer. Oncotarget. 2015 Mar 20; 6(8):6029-39. Tsigelny IF, Wheler JJ, Greenberg JP, Kouznetsova VL, Stewart DJ, Bazhenova L, Kurzrock R. PMID: 25760241; PMCID: PMC4467419.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    32. Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023; PMCID: PMC4944825.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    33. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211; PMCID: PMC4290715.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184; PMCID: PMC4250372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. bHLH Transcription factors inhibitors for cancer therapy: general features for in silico drug design. Curr Med Chem. 2014; 21(28):3227-43. Tsigelny IF, Kouznetsova VL, Pingle SC, Kesari S. PMID: 24735358.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640; PMCID: PMC4449729.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    37. Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Bioorg Med Chem. 2013 Sep 15; 21(18):5855-69. Tsigelny IF, Kouznetsova VL, Biswas N, Mahata SK, O'Connor DT. PMID: 23916146.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327; PMCID: PMC3722616.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    39. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano. 2013 May 28; 7(5):4289-98. Chao Y, Karmali PP, Mukthavaram R, Kesari S, Kouznetsova VL, Tsigelny IF, Simberg D. PMID: 23614696.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    40. A hierarchical coherent-gene-group model for brain development. Genes Brain Behav. 2013 Mar; 12(2):147-65. Tsigelny IF, Kouznetsova VL, Baitaluk M, Changeux JP. PMID: 23173912.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    41. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One. 2012; 7(7):e40796. Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam SK. PMID: 22808265; PMCID: PMC3396597.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    42. An all-atom model of the structure of human copper transporter 1. Cell Biochem Biophys. 2012 Jul; 63(3):223-34. Tsigelny IF, Sharikov Y, Greenberg JP, Miller MA, Kouznetsova VL, Larson CA, Howell SB. PMID: 22569840; PMCID: PMC3590913.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    43. A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol. 2012 Apr 01; 364(1):11-21. Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush KT, Willert K, Farquhar MG, Nigam SK. PMID: 22290330; PMCID: PMC3310225.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    44. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. PMID: 21499753.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    45. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem. 2011 Jun 01; 19(11):3320-40. Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam SK. PMID: 21571536; PMCID: PMC3310230.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    46. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011 Jun 03; 10(6):2842-51. Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK. PMID: 21476605; PMCID: PMC3201759.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    47. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1330-41. Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam SK. PMID: 19726549; PMCID: PMC2781331.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    48. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008 Dec 09; 1(49):ra16. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam SK. PMID: 19066399; PMCID: PMC3016920.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    49. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol. 2008 Oct; 6(5):885-904. Tsigelny IF, Greenberg J, Kouznetsova V, Nigam SK. PMID: 18942157; PMCID: PMC2676871.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    50. MAPAS: a tool for predicting membrane-contacting protein surfaces. Nat Methods. 2008 Feb; 5(2):119. Sharikov Y, Walker RC, Greenberg J, Kouznetsova V, Nigam SK, Miller MA, Masliah E, Tsigelny IF. PMID: 18235431.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    51. Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response. IEEE Trans Med Imaging. 2000 Mar; 19(3):203-10. Hoover A, Kouznetsova V, Goldbaum M. PMID: 10875704.
      View in: PubMed   Mentions: 268     Fields:    Translation:Humans
    52. Locating blood vessels in retinal images by piece-wise threshold probing of a matched filter response. Proc AMIA Symp. 1998; 931-5. Hoover A, Kouznetsova V, Goldbaum M. PMID: 9929355; PMCID: PMC2232087.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
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