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Kevin Corbett

Title(s)Associate Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Phone858-534-7267
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolPostdoctoral2011Biological Chemistry & Molecular Pharmacology
    University of California, BerkeleyPh.D.2005Molecular Cell Biology
    University of VirginiaB.S.2000Chemistry

    Collapse Overview 
    Collapse Overview
    Our lab is focused on the molecular mechanisms of chromosome segregation in meiosis. We use biochemistry, X-ray crystallography, and genetics in S. cerevisiae to probe the structure, function, and interactions between proteins involved in meiotic chromosome pairing, crossover initiation and maturation, and chromosome segregation. A new focus involves the structure and function of the first identified bacterial HORMA domain proteins, a family of signaling proteins previously thought to exist only in eukaryotes.

    Collapse Research 
    Collapse Research Activities and Funding
    Expanding the CRISPR/Cas toolbox for RNA modulation
    NIH/NIGMS R01GM128464May 21, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Molecular mechanisms of chromosome organization and recombination control by the meiotic chromosome axis
    NIH/NIGMS R01GM104141Dec 10, 2012 - Jan 31, 2022
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Xu H, Tong Z, Ye Q, Sun T, Hong Z, Zhang L, Bortnick A, Cho S, Beuzer P, Axelrod J, Hu Q, Wang M, Evans SM, Murre C, Lu LF, Sun S, Corbett KD, Cang H. Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy. Proc Natl Acad Sci U S A. 2019 Aug 23. PMID: 31444302.
      View in: PubMed
    2. Plowman R, Singh N, Tromer EC, Payan A, Duro E, Spanos C, Rappsilber J, Snel B, Kops GJPL, Corbett KD, Marston AL. The molecular basis of monopolin recruitment to the kinetochore. Chromosoma. 2019 Apr 30. PMID: 31037469.
      View in: PubMed
    3. Arora K, Corbett KD. The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. Nucleic Acids Res. 2019 Mar 18; 47(5):2365-2376. PMID: 30566683.
      View in: PubMed
    4. Patel L, Kang R, Rosenberg SC, Qiu Y, Raviram R, Chee S, Hu R, Ren B, Cole F, Corbett KD. Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Nat Struct Mol Biol. 2019 Mar; 26(3):164-174. PMID: 30778236.
      View in: PubMed
    5. West AM, Rosenberg SC, Ur SN, Lehmer MK, Ye Q, Hagemann G, Caballero I, Usón I, MacQueen AJ, Herzog F, Corbett KD. A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. Elife. 2019 Jan 18; 8. PMID: 30657449.
      View in: PubMed
    6. Singh N, Corbett KD. The budding-yeast RWD protein Csm1 scaffolds diverse protein complexes through a conserved structural mechanism. Protein Sci. 2018 Dec; 27(12):2094-2100. PMID: 30252178.
      View in: PubMed
    7. Kim DH, Han JS, Ly P, Ye Q, McMahon MA, Myung K, Corbett KD, Cleveland DW. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018 10 19; 9(1):4354. PMID: 30341343.
      View in: PubMed
    8. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Author Correction: Blocking Zika virus vertical transmission. Sci Rep. 2018 Jun 05; 8(1):8794. PMID: 29867187.
      View in: PubMed
    9. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Blocking Zika virus vertical transmission. Sci Rep. 2018 01 19; 8(1):1218. PMID: 29352135.
      View in: PubMed
    10. West AMV, Komives EA, Corbett KD. Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Res. 2018 Jan 09; 46(1):279-292. PMID: 29186573.
      View in: PubMed
    11. Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat Genet. 2018 Jan; 50(1):73-82. PMID: 29255264.
      View in: PubMed
    12. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. PMID: 28803727.
      View in: PubMed
    13. Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD. The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J. 2017 08 15; 36(16):2419-2434. PMID: 28659378.
      View in: PubMed
    14. Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett KD, Oegema K, Desai A. Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Dev Cell. 2017 05 22; 41(4):424-437.e4. PMID: 28535376.
      View in: PubMed
    15. Liang J, Singh N, Carlson CR, Albuquerque CP, Corbett KD, Zhou H. Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev. 2017 04 15; 31(8):802-815. PMID: 28487408.
      View in: PubMed
    16. Corbett KD. Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing. Prog Mol Subcell Biol. 2017; 56:429-455. PMID: 28840248.
      View in: PubMed
    17. Corbett KD, Harrison SC. Molecular Architecture of the Yeast Monopolin Complex. Cell Rep. 2016 10 11; 17(3):929. PMID: 27732865.
      View in: PubMed
    18. Ye Q, Ur SN, Su TY, Corbett KD. Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. EMBO J. 2016 10 04; 35(19):2139-2151. PMID: 27491543.
      View in: PubMed
    19. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
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    20. Albuquerque CP, Yeung E, Ma S, Fu T, Corbett KD, Zhou H. A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. PLoS One. 2015; 10(12):e0143810. PMID: 26633173; PMCID: PMC4669148.
    21. Rosenberg SC, Corbett KD. The multifaceted roles of the HORMA domain in cellular signaling. J Cell Biol. 2015 Nov 23; 211(4):745-55. PMID: 26598612; PMCID: PMC4657174.
    22. Nithianantham S, Le S, Seto E, Jia W, Leary J, Corbett KD, Moore JK, Al-Bassam J. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble aß-tubulin pool for microtubule dynamics. Elife. 2015 Jul 24; 4. PMID: 26208336; PMCID: PMC4574351.
    23. Ye Q, Rosenberg SC, Moeller A, Speir JA, Su TY, Corbett KD. TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. Elife. 2015 Apr 28; 4. PMID: 25918846.
      View in: PubMed
    24. Kim Y, Rosenberg SC, Kugel CL, Kostow N, Rog O, Davydov V, Su TY, Dernburg AF, Corbett KD. The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. Dev Cell. 2014 Nov 24; 31(4):487-502. PMID: 25446517; PMCID: PMC4254552.
    25. Sarangapani KK, Duro E, Deng Y, Alves Fde L, Ye Q, Opoku KN, Ceto S, Rappsilber J, Corbett KD, Biggins S, Marston AL, Asbury CL. Sister kinetochores are mechanically fused during meiosis I in yeast. Science. 2014 Oct 10; 346(6206):248-51. PMID: 25213378.
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    26. Corbett KD, Desai A. A new piece in the kinetochore jigsaw puzzle. J Cell Biol. 2014 Aug 18; 206(4):457-9. PMID: 25135931; PMCID: PMC4137055.
    27. Bhandari D, Zhang J, Menon S, Lord C, Chen S, Helm JR, Thorsen K, Corbett KD, Hay JC, Ferro-Novick S. Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits. Mol Biol Cell. 2013 Sep; 24(17):2727-38. PMID: 23864707; PMCID: PMC3756924.
    28. Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013 Jul 19; 8(7):1611-20. PMID: 23679870; PMCID: PMC3806902.
    29. Al-Bassam J, Corbett KD. a-Tubulin acetylation from the inside out. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19515-6. PMID: 23150594; PMCID: PMC3511746.
    30. Corbett KD, Harrison SC. Molecular architecture of the yeast monopolin complex. Cell Rep. 2012 Jun 28; 1(6):583-9. PMID: 22813733; PMCID: PMC3494995.
    31. Maddox PS, Corbett KD, Desai A. Structure, assembly and reading of centromeric chromatin. Curr Opin Genet Dev. 2012 Apr; 22(2):139-47. PMID: 22178421; PMCID: PMC3319190.
    32. Cho US, Corbett KD, Al-Bassam J, Bellizzi JJ, De Wulf P, Espelin CW, Miranda JJ, Simons K, Wei RR, Sorger PK, Harrison SC. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401. PMID: 21467141.
      View in: PubMed
    33. Corbett KD, Berger JM. Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins. 2010 Oct; 78(13):2738-44. PMID: 20635416.
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    34. Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67. PMID: 20723757; PMCID: PMC2955198.
    35. Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr; 17(4):438-44. PMID: 20208545; PMCID: PMC2920743.
    36. Stuchinskaya T, Mitchenall LA, Schoeffler AJ, Corbett KD, Berger JM, Bates AD, Maxwell A. How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol. 2009 Feb 06; 385(5):1397-408. PMID: 19094994; PMCID: PMC4343537.
    37. Corbett KD, Benedetti P, Berger JM. Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nat Struct Mol Biol. 2007 Jul; 14(7):611-9. PMID: 17603498.
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    38. Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 2007 Apr; 16(4):695-703. PMID: 17384234.
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    39. Corbett KD, Berger JM. Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Res. 2006; 34(15):4269-77. PMID: 16920739; PMCID: PMC1616964.
    40. Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM. Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem. 2006 Sep 08; 281(36):26745-53. PMID: 16809340.
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    41. Corbett KD, Schoeffler AJ, Thomsen ND, Berger JM. The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol. 2005 Aug 19; 351(3):545-61. PMID: 16023670.
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    42. Corbett KD, Berger JM. Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI. Structure. 2005 Jun; 13(6):873-82. PMID: 15939019.
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    43. Hancock SM, Corbett K, Fordham-Skelton AP, Gatehouse JA, Davis BG. Developing promiscuous glycosidases for glycoside synthesis: residues W433 and E432 in Sulfolobus solfataricus beta-glycosidase are important glucoside- and galactoside-specificity determinants. Chembiochem. 2005 May; 6(5):866-75. PMID: 15846595.
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    44. Chow MA, McElroy KE, Corbett KD, Berger JM, Kirsch JF. Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase. Biochemistry. 2004 Oct 12; 43(40):12780-7. PMID: 15461450.
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    45. Corbett KD, Shultzaberger RK, Berger JM. The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7293-8. PMID: 15123801.
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    46. Corbett KD, Berger JM. Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct. 2004; 33:95-118. PMID: 15139806.
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    47. Corbett KD, Berger JM. Emerging roles for plant topoisomerase VI. Chem Biol. 2003 Feb; 10(2):107-11. PMID: 12618182.
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    48. Corbett KD, Berger JM. Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J. 2003 Jan 02; 22(1):151-63. PMID: 12505993.
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    49. Godbold GD, Corbett KD, Mann BJ. A Rho-like small GTPase of Entamoeba histolytica contains an unusual amino acid residue in a conserved GDP-stabilization region and is not a substrate for C3 exoenzyme. Exp Parasitol. 2002 Jun-Jul; 101(2-3):107-10. PMID: 12427464.
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    50. Corbett K, Fordham-Skelton AP, Gatehouse JA, Davis BG. Tailoring the substrate specificity of the beta-glycosidase from the thermophilic archaeon Sulfolobus solfataricus. FEBS Lett. 2001 Dec 14; 509(3):355-60. PMID: 11749955.
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    51. Corbett KD, Alber T. The many faces of Ras: recognition of small GTP-binding proteins. Trends Biochem Sci. 2001 Dec; 26(12):710-6. PMID: 11738594.
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    52. Greenblatt DJ, Wright CE, von Moltke LL, Harmatz JS, Ehrenberg BL, Harrel LM, Corbett K, Counihan M, Tobias S, Shader RI. Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences. Clin Pharmacol Ther. 1998 Sep; 64(3):237-47. PMID: 9757147.
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