Kevin Corbett

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0660
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolPostdoctoral2011Biological Chemistry & Molecular Pharmacology
    University of California, BerkeleyPh.D.2005Molecular Cell Biology
    University of VirginiaB.S.2000Chemistry

    Collapse Overview 
    Collapse Overview
    Our lab is focused on the molecular mechanisms of chromosome segregation in meiosis. We use biochemistry, X-ray crystallography, and genetics in S. cerevisiae to probe the structure, function, and interactions between proteins involved in meiotic chromosome pairing, crossover initiation and maturation, and chromosome segregation.

    Research Focus Areas:

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett K, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Author Correction: Blocking Zika virus vertical transmission. Sci Rep. 2018 Jun 05; 8(1):8794. PMID: 29867187.
      View in: PubMed
    2. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett K, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Blocking Zika virus vertical transmission. Sci Rep. 2018 Jan 19; 8(1):1218. PMID: 29352135.
      View in: PubMed
    3. West AMV, Komives EA, Corbett K. Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Res. 2018 Jan 09; 46(1):279-292. PMID: 29186573.
      View in: PubMed
    4. Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett K, Wang D, Zhou H, Ren B. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat Genet. 2018 Jan; 50(1):73-82. PMID: 29255264.
      View in: PubMed
    5. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett K, Swanson MS, Yeo GW. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. PMID: 28803727.
      View in: PubMed
    6. Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett K. The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J. 2017 08 15; 36(16):2419-2434. PMID: 28659378.
      View in: PubMed
    7. Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett K, Oegema K, Desai A. Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Dev Cell. 2017 05 22; 41(4):424-437.e4. PMID: 28535376.
      View in: PubMed
    8. Liang J, Singh N, Carlson CR, Albuquerque CP, Corbett K, Zhou H. Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev. 2017 04 15; 31(8):802-815. PMID: 28487408.
      View in: PubMed
    9. Corbett K. Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing. Prog Mol Subcell Biol. 2017; 56:429-455. PMID: 28840248.
      View in: PubMed
    10. Corbett K, Harrison SC. Molecular Architecture of the Yeast Monopolin Complex. Cell Rep. 2016 10 11; 17(3):929. PMID: 27732865.
      View in: PubMed
    11. Ye Q, Ur SN, Su TY, Corbett K. Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. EMBO J. 2016 10 04; 35(19):2139-2151. PMID: 27491543.
      View in: PubMed
    12. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett K, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
      View in: PubMed
    13. Albuquerque CP, Yeung E, Ma S, Fu T, Corbett K, Zhou H. A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. PLoS One. 2015; 10(12):e0143810. PMID: 26633173; PMCID: PMC4669148.
    14. Rosenberg SC, Corbett K. The multifaceted roles of the HORMA domain in cellular signaling. J Cell Biol. 2015 Nov 23; 211(4):745-55. PMID: 26598612; PMCID: PMC4657174.
    15. Nithianantham S, Le S, Seto E, Jia W, Leary J, Corbett K, Moore JK, Al-Bassam J. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble aß-tubulin pool for microtubule dynamics. Elife. 2015 Jul 24; 4. PMID: 26208336; PMCID: PMC4574351.
    16. Ye Q, Rosenberg SC, Moeller A, Speir JA, Su TY, Corbett K. TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. Elife. 2015 Apr 28; 4. PMID: 25918846; PMCID: PMC4439613.
    17. Kim Y, Rosenberg SC, Kugel CL, Kostow N, Rog O, Davydov V, Su TY, Dernburg AF, Corbett K. The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. Dev Cell. 2014 Nov 24; 31(4):487-502. PMID: 25446517; PMCID: PMC4254552.
    18. Sarangapani KK, Duro E, Deng Y, Alves Fde L, Ye Q, Opoku KN, Ceto S, Rappsilber J, Corbett K, Biggins S, Marston AL, Asbury CL. Sister kinetochores are mechanically fused during meiosis I in yeast. Science. 2014 Oct 10; 346(6206):248-51. PMID: 25213378.
      View in: PubMed
    19. Corbett K, Desai A. A new piece in the kinetochore jigsaw puzzle. J Cell Biol. 2014 Aug 18; 206(4):457-9. PMID: 25135931; PMCID: PMC4137055.
    20. Bhandari D, Zhang J, Menon S, Lord C, Chen S, Helm JR, Thorsen K, Corbett K, Hay JC, Ferro-Novick S. Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits. Mol Biol Cell. 2013 Sep; 24(17):2727-38. PMID: 23864707; PMCID: PMC3756924.
    21. Xu D, Young JH, Krahn JM, Song D, Corbett K, Chazin WJ, Pedersen LC, Esko JD. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013 Jul 19; 8(7):1611-20. PMID: 23679870; PMCID: PMC3806902.
    22. Al-Bassam J, Corbett K. a-Tubulin acetylation from the inside out. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19515-6. PMID: 23150594; PMCID: PMC3511746.
    23. Corbett K, Harrison SC. Molecular architecture of the yeast monopolin complex. Cell Rep. 2012 Jun 28; 1(6):583-9. PMID: 22813733; PMCID: PMC3494995.
    24. Maddox PS, Corbett K, Desai A. Structure, assembly and reading of centromeric chromatin. Curr Opin Genet Dev. 2012 Apr; 22(2):139-47. PMID: 22178421; PMCID: PMC3319190.
    25. Corbett K, Berger JM. Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins. 2010 Oct; 78(13):2738-44. PMID: 20635416; PMCID: PMC2927708.
    26. Corbett K, Yip CK, Ee LS, Walz T, Amon A, Harrison SC. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67. PMID: 20723757; PMCID: PMC2955198.
    27. Abraham J, Corbett K, Farzan M, Choe H, Harrison SC. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr; 17(4):438-44. PMID: 20208545; PMCID: PMC2920743.
    28. Stuchinskaya T, Mitchenall LA, Schoeffler AJ, Corbett K, Berger JM, Bates AD, Maxwell A. How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol. 2009 Feb 06; 385(5):1397-408. PMID: 19094994; PMCID: PMC4343537.
    29. Corbett K, Benedetti P, Berger JM. Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nat Struct Mol Biol. 2007 Jul; 14(7):611-9. PMID: 17603498.
      View in: PubMed
    30. Douglas AE, Corbett K, Berger JM, McFadden G, Handel TM. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 2007 Apr; 16(4):695-703. PMID: 17384234; PMCID: PMC2203349.
    31. Corbett K, Berger JM. Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Res. 2006; 34(15):4269-77. PMID: 16920739; PMCID: PMC1616964.
    32. Reynolds KA, Thomson JM, Corbett K, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM. Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem. 2006 Sep 08; 281(36):26745-53. PMID: 16809340.
      View in: PubMed
    33. Corbett K, Schoeffler AJ, Thomsen ND, Berger JM. The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol. 2005 Aug 19; 351(3):545-61. PMID: 16023670.
      View in: PubMed
    34. Corbett K, Berger JM. Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI. Structure. 2005 Jun; 13(6):873-82. PMID: 15939019.
      View in: PubMed
    35. Chow MA, McElroy KE, Corbett K, Berger JM, Kirsch JF. Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase. Biochemistry. 2004 Oct 12; 43(40):12780-7. PMID: 15461450.
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    36. Corbett K, Shultzaberger RK, Berger JM. The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7293-8. PMID: 15123801; PMCID: PMC409912.
    37. Corbett K, Berger JM. Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct. 2004; 33:95-118. PMID: 15139806.
      View in: PubMed
    38. Corbett K, Berger JM. Emerging roles for plant topoisomerase VI. Chem Biol. 2003 Feb; 10(2):107-11. PMID: 12618182.
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    39. Corbett K, Berger JM. Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J. 2003 Jan 02; 22(1):151-63. PMID: 12505993; PMCID: PMC140052.