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Erica Saphire

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0912
La Jolla CA 92093
Phone000-000-NULL
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    Collapse Research 
    Collapse Research Activities and Funding
    Consortium for Immunotherapeutics against Emerging Viral Threats
    NIH/NIAID U19AI142790May 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Rationally Designed Pan-Ebolavirus Vaccine
    NIH/NIAID R01AI132204Jun 20, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Function and assembly of the Ebola virus nucleocapsid
    NIH/NIAID R01AI118016Mar 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Function and assembly of the Ebola virus nucleocapsid
    NIH/NIAID R56AI118016Mar 1, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Interpreting a hard-won structure of the arenavirus prefusion glycoprotein
    NIH/NIAID R21AI116112Dec 1, 2014 - Nov 30, 2016
    Role: Principal Investigator
    Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers
    NIH/NIAID U19AI109762Mar 15, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Analysis of immunotherapeutics to native Marburg virus epitopes
    NIH/NIAID R01AI089498Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator
    STRUCTURE DRIVEN ANALYSIS OF EBOLA VIRUS RECEPTOR BINDING SITE
    NIH/NIAID R01AI081982Dec 15, 2009 - Nov 30, 2014
    Role: Principal Investigator
    Immunotherapeutics against Marburg: Development, structural &functional anaylsis
    NIH/NIAID U01AI082156Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    EBOLA VIRAL GLYCOPROTEINS: STRUCTURAL ANALYSIS
    NIH/NIAID R01AI067927Jul 14, 2009 - Oct 31, 2009
    Role: Principal Investigator
    Immunotherapeutics vs Ebola Sudan: Development, Structural &Functional Analysis
    NIH/NIAID U01AI070530Sep 15, 2006 - Aug 31, 2011
    Role: Principal Investigator
    Structural Studies of Ebola Viral Pathogenesis
    NIH/NIAID R21AI053423Sep 15, 2002 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SnapShot: Enveloped Virus Entry. Cell. 2020 Aug 06; 182(3):786-786.e1. Mercer J, Lee JE, Saphire EO, Freeman SA. PMID: 32763187.
      View in: PubMed   Mentions:    Fields:    
    2. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell. 2020 Jul 03. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B, Hastie KM, Parker MD, Partridge DG, Evans CM, Freeman TM, de Silva TI, McDanal C, Perez LG, Tang H, Moon-Walker A, Whelan SP, LaBranche CC, Saphire EO, Montefiori DC. PMID: 32697968.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCellsPHPublic Health
    3. Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2. Trends Microbiol. 2020 08; 28(8):605-618. Wang YT, Landeras-Bueno S, Hsieh LE, Terada Y, Kim K, Ley K, Shresta S, Saphire EO, Regla-Nava JA. PMID: 32507543.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. Cell Host Microbe. 2020 06 10; 27(6):976-991.e11. Ilinykh PA, Huang K, Santos RI, Gilchuk P, Gunn BM, Karim MM, Liang J, Fouch ME, Davidson E, Parekh DV, Kimble JB, Pietzsch CA, Meyer M, Kuzmina NA, Zeitlin L, Saphire EO, Alter G, Crowe JE, Bukreyev A. PMID: 32320678.
      View in: PubMed   Mentions: 1     Fields:    
    5. Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization. Immunity. 2020 02 18; 52(2):388-403.e12. Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE. PMID: 32023489.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111. Viruses. 2020 01 15; 12(1). Lin AE, Diehl WE, Cai Y, Finch CL, Akusobi C, Kirchdoerfer RN, Bollinger L, Schaffner SF, Brown EA, Saphire EO, Andersen KG, Kuhn JH, Luban J, Sabeti PC. PMID: 31952352.
      View in: PubMed   Mentions:    Fields:    
    7. A glimpse into immune responses evolving against Ebola virus. Nat Med. 2019 10; 25(10):1470-1471. Saphire EO. PMID: 31591604.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Diverse Morphology and Structural Features of Old and New World Hantaviruses. Viruses. 2019 09 16; 11(9). Parvate A, Williams EP, Taylor MK, Chu YK, Lanman J, Saphire EO, Jonsson CB. PMID: 31527500.
      View in: PubMed   Mentions: 1     Fields:    
    9. Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization. Cell. 2019 08 08; 178(4):1004-1015.e14. Hastie KM, Cross RW, Harkins SS, Zandonatti MA, Koval AP, Heinrich ML, Rowland MM, Robinson JE, Geisbert TW, Garry RF, Branco LM, Saphire EO. PMID: 31398326.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment. mBio. 2019 07 23; 10(4). Landeras-Bueno S, Oda SI, Norris MJ, Li Salie Z, Guenaga J, Wyatt RT, Saphire EO. PMID: 31337716.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    11. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. 2019 05 30; 177(6):1566-1582.e17. Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. PMID: 31104840.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex. Acta Crystallogr F Struct Biol Commun. 2019 May 01; 75(Pt 5):340-347. Kirchdoerfer RN, Saphire EO, Ward AB. PMID: 31045563.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun. 2019 04 17; 10(1):1788. King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE, Saphire EO. PMID: 30996276.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection. J Virol. 2019 04 15; 93(8). Williamson LE, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz BJ, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE. PMID: 30728263.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Structural basis of broad ebolavirus neutralization by a human survivor antibody. Nat Struct Mol Biol. 2019 03; 26(3):204-212. West BR, Wec AZ, Moyer CL, Fusco ML, Ilinykh PA, Huang K, Wirchnianski AS, James RM, Herbert AS, Hui S, Goodwin E, Howell KA, Kailasan S, Aman MJ, Walker LM, Dye JM, Bukreyev A, Chandran K, Saphire EO. PMID: 30833785.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function. Structure. 2019 04 02; 27(4):660-668.e4. Bruhn JF, Hotard AL, Spiropoulou CF, Lo MK, Saphire EO. PMID: 30799076.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein. J Infect Dis. 2019 01 09; 219(3):415-419. Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO. PMID: 30203042.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model. Cell Rep. 2018 11 13; 25(7):1982-1993.e4. Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, Kobinger GP, He S, Qiu X, Kobasa D, Humeau L, Sardesai NY, Ahmed R, Weiner DB. PMID: 30428362.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Antibody-mediated protection against Ebola virus. Nat Immunol. 2018 11; 19(11):1169-1178. Saphire EO, Schendel SL, Gunn BM, Milligan JC, Alter G. PMID: 30333617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. mBio. 2018 09 11; 9(5). West BR, Moyer CL, King LB, Fusco ML, Milligan JC, Hui S, Saphire EO. PMID: 30206174.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors. Cell Rep. 2018 08 14; 24(7):1816-1829. Meyer M, Yoshida A, Ramanathan P, Saphire EO, Collins PL, Crowe JE, Samal S, Bukreyev A. PMID: 30110638.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell. 2018 08 09; 174(4):938-952.e13. Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe JE, Davis CW, Georgiou G, Krammer F, Kyratsous CA, Lai JR, Nykiforuk C, Pauly MH, Rijal P, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM. PMID: 30096313.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCellsPHPublic Health
    23. A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host Microbe. 2018 08 08; 24(2):221-233.e5. Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, Lai J, Chandran K, Zeitlin L, Crowe JE, Lauffenburger D, Kawaoka Y, Kobinger GP, Andersen KG, Dye JM, Saphire EO, Alter G. PMID: 30092199.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity. 2018 08 21; 49(2):363-374.e10. Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE. PMID: 30029854.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. The structural basis for filovirus neutralization by monoclonal antibodies. Curr Opin Immunol. 2018 08; 53:196-202. King LB, West BR, Schendel SL, Saphire EO. PMID: 29940415.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    26. Lassa virus glycoprotein: stopping a moving target. Curr Opin Virol. 2018 08; 31:52-58. Hastie KM, Saphire EO. PMID: 29843991.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region. Nat Microbiol. 2018 06; 3(6):670-677. Flyak AI, Kuzmina N, Murin CD, Bryan C, Davidson E, Gilchuk P, Gulka CP, Ilinykh PA, Shen X, Huang K, Ramanathan P, Turner H, Fusco ML, Lampley R, Kose N, King H, Sapparapu G, Doranz BJ, Ksiazek TG, Wright DW, Saphire EO, Ward AB, Bukreyev A, Crowe JE. PMID: 29736037.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever. Sci Rep. 2018 04 12; 8(1):5939. Boisen ML, Hartnett JN, Shaffer JG, Goba A, Momoh M, Sandi JD, Fullah M, Nelson DKS, Bush DJ, Rowland MM, Heinrich ML, Koval AP, Cross RW, Barnes KG, Lachenauer AE, Lin AE, Nekoui M, Kotliar D, Winnicki SM, Siddle KJ, Gbakie M, Fonnie M, Koroma VJ, Kanneh L, Kulakosky PC, Hastie KM, Wilson RB, Andersen KG, Folarin OO, Happi CT, Sabeti PC, Geisbert TW, Saphire EO, Khan SH, Grant DS, Schieffelin JS, Branco LM, Garry RF. PMID: 29651117.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine. J Biol Chem. 2018 03 02; 293(9):3335-3349. Del Vecchio K, Frick CT, Gc JB, Oda SI, Gerstman BS, Saphire EO, Chapagain PP, Stahelin RV. PMID: 29348171.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe. 2018 Jan 10; 23(1):101-109.e4. King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE, Saphire EO. PMID: 29324225.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    31. Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure. 2017 12 05; 25(12):1820-1828.e2. Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE, Meiler J. PMID: 29153506.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    32. Structural basis for antibody-mediated neutralization of Lassa virus. Science. 2017 06 02; 356(6341):923-928. Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO. PMID: 28572385.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    33. How to turn competitors into collaborators. Nature. 2017 01 18; 541(7637):283-285. Saphire EO, Dye JM, Kobinger GP, Zeitlin L, Chandran K, Garry RF. PMID: 28102273.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Crystal Structure of the Marburg Virus VP35 Oligomerization Domain. J Virol. 2017 Jan 15; 91(2). Bruhn JF, Kirchdoerfer RN, Urata SM, Li S, Tickle IJ, Bricogne G, Saphire EO. PMID: 27847355.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    35. Filovirus Structural Biology: The Molecules in the Machine. Curr Top Microbiol Immunol. 2017; 411:381-417. Kirchdoerfer RN, Wasserman H, Amarasinghe GK, Saphire EO. PMID: 28795188.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    36. The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis. PLoS Pathog. 2016 Oct; 12(10):e1005937. Kirchdoerfer RN, Moyer CL, Abelson DM, Saphire EO. PMID: 27755595.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    37. A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses. Science. 2016 10 21; 354(6310):350-354. Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K. PMID: 27608667.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    38. Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection. J Infect Dis. 2016 10 15; 214(suppl 3):S210-S217. Cross RW, Boisen ML, Millett MM, Nelson DS, Oottamasathien D, Hartnett JN, Jones AB, Goba A, Momoh M, Fullah M, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Brown BL, Pham H, Rowland MM, Agans KN, Geisbert JB, Heinrich ML, Kulakosky PC, Shaffer JG, Schieffelin JS, Kargbo B, Gbetuwa M, Gevao SM, Wilson RB, Saphire EO, Pitts KR, Khan SH, Grant DS, Geisbert TW, Branco LM, Garry RF. PMID: 27587634.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. Nat Microbiol. 2016 Aug 08; 1(9):16128. Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB. PMID: 27562261.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    40. More than Meets the Eye: Hidden Structures in the Proteome. Annu Rev Virol. 2016 09 29; 3(1):373-386. Wasserman H, Saphire EO. PMID: 27482901.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    41. An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. J Infect Dis. 2016 10 15; 214(suppl 3):S110-S121. Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF. PMID: 27402779.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    42. Feverish Quest for Ebola Immunotherapy: Straight or Cocktail? Trends Microbiol. 2016 09; 24(9):684-686. Saphire EO, Aman MJ. PMID: 27338027.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. Nat Commun. 2016 05 10; 7:11544. Robinson JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H, Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, Rowland MM, Heinrich ML, Martínez-Sobrido L, Cheng B, de la Torre JC, Andersen KG, Goba A, Momoh M, Fullah M, Gbakie M, Kanneh L, Koroma VJ, Fonnie R, Jalloh SC, Kargbo B, Vandi MA, Gbetuwa M, Ikponmwosa O, Asogun DA, Okokhere PO, Follarin OA, Schieffelin JS, Pitts KR, Geisbert JB, Kulakoski PC, Wilson RB, Happi CT, Sabeti PC, Gevao SM, Khan SH, Grant DS, Geisbert TW, Saphire EO, Branco LM, Garry RF. PMID: 27161536.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    44. Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site. Cell Rep. 2016 05 17; 15(7):1514-1526. Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, Kroeker A, Vu H, Herbert AS, Fusco ML, Nyakatura EK, Lai JR, Keck ZY, Foung SKH, Saphire EO, Zeitlin L, Ward AB, Chandran K, Doranz BJ, Kobinger GP, Dye JM, Aman MJ. PMID: 27160900.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    45. Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV. Nat Struct Mol Biol. 2016 06; 23(6):513-521. Hastie KM, Igonet S, Sullivan BM, Legrand P, Zandonatti MA, Robinson JE, Garry RF, Rey FA, Oldstone MB, Saphire EO. PMID: 27111888.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    46. Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z. J Virol. 2016 May; 90(9):4556-62. Hastie KM, Zandonatti M, Liu T, Li S, Woods VL, Saphire EO. PMID: 26912609.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    47. Two-mAb cocktail protects macaques against the Makona variant of Ebola virus. Sci Transl Med. 2016 Mar 09; 8(329):329ra33. Qiu X, Audet J, Lv M, He S, Wong G, Wei H, Luo L, Fernando L, Kroeker A, Fausther Bovendo H, Bello A, Li F, Ye P, Jacobs M, Ippolito G, Saphire EO, Bi S, Shen B, Gao GF, Zeitlin L, Feng J, Zhang B, Kobinger GP. PMID: 26962157.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    48. Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies. mBio. 2016 Feb 23; 7(1):e02154-15. Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EO. PMID: 26908579.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    49. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. Science. 2016 Mar 04; 351(6277):1078-83. Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM. PMID: 26912366.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    50. Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Cell. 2016 Jan 28; 164(3):392-405. Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE. PMID: 26806128.
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    51. Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression. J Virol. 2016 02 15; 90(4):1839-48. Oda S, Noda T, Wijesinghe KJ, Halfmann P, Bornholdt ZA, Abelson DM, Armbrust T, Stahelin RV, Kawaoka Y, Saphire EO. PMID: 26656687.
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    52. Potent Antibody Protection against an Emerging Alphavirus Threat. Cell. 2015 Nov 19; 163(5):1053-1054. Kielian M, Saphire EO. PMID: 26590413.
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    53. Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses. J Virol. 2016 01 01; 90(1):266-78. Holtsberg FW, Shulenin S, Vu H, Howell KA, Patel SJ, Gunn B, Karim M, Lai JR, Frei JC, Nyakatura EK, Zeitlin L, Douglas R, Fusco ML, Froude JW, Saphire EO, Herbert AS, Wirchnianski AS, Lear-Rooney CM, Alter G, Dye JM, Glass PJ, Warfield KL, Aman MJ. PMID: 26468533.
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    54. Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. PLoS Pathog. 2015 Oct; 11(10):e1005212. Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, Nykiforuk C, Aman MJ, Berry JD, Saphire EO. PMID: 26452225.
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    55. Swift antibodies to counter emerging viruses. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10082-3. Burton DR, Saphire EO. PMID: 26261336.
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    56. Development of Prototype Filovirus Recombinant Antigen Immunoassays. J Infect Dis. 2015 Oct 01; 212 Suppl 2:S359-67. Boisen ML, Oottamasathien D, Jones AB, Millett MM, Nelson DS, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Hartnett JN, Rowland MM, Heinrich ML, Akdag M, Goba A, Momoh M, Fullah M, Baimba F, Gbakie M, Safa S, Fonnie R, Kanneh L, Cross RW, Geisbert JB, Geisbert TW, Kulakosky PC, Grant DS, Shaffer JG, Schieffelin JS, Wilson RB, Saphire EO, Branco LM, Garry RF, Khan SH, Pitts KR. PMID: 26232440.
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    57. Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. PLoS Pathog. 2015 Jun; 11(6):e1005016. Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, Nykiforuk C, Aman MJ, Berry JD, Berry J, Saphire EO. PMID: 26115029.
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    58. Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex. Cell Rep. 2015 Jul 07; 12(1):140-149. Kirchdoerfer RN, Abelson DM, Li S, Wood MR, Saphire EO. PMID: 26119732.
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    59. New Advances in the Effort against Ebola. Cell Host Microbe. 2015 May 13; 17(5):545-7. Saphire EO. PMID: 25974296.
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    60. High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus. J Infect Dis. 2015 Oct 01; 212 Suppl 2:S167-71. Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO. PMID: 25957961.
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    61. Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell. 2015 Feb 26; 160(5):904-912. Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO. PMID: 25723165.
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    62. Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 2015 Feb 26; 160(5):893-903. Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, Crowe JE. PMID: 25723164.
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    63. Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak. Viral Immunol. 2015 Feb; 28(1):19-31. Boisen ML, Schieffelin JS, Goba A, Oottamasathien D, Jones AB, Shaffer JG, Hastie KM, Hartnett JN, Momoh M, Fullah M, Gabiki M, Safa S, Zandonatti M, Fusco M, Bornholdt Z, Abelson D, Gire SK, Andersen KG, Tariyal R, Stremlau M, Cross RW, Geisbert JB, Pitts KR, Geisbert TW, Kulakoski P, Wilson RB, Henderson L, Sabeti PC, Grant DS, Garry RF, Saphire EO, Branco LM, Khan SH. PMID: 25531344.
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    64. Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17182-7. Murin CD, Fusco ML, Bornholdt ZA, Qiu X, Olinger GG, Zeitlin L, Kobinger GP, Ward AB, Saphire EO. PMID: 25404321.
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    65. Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names. Viruses. 2014 Sep 26; 6(9):3663-82. Kuhn JH, Andersen KG, Bào Y, Bavari S, Becker S, Bennett RS, Bergman NH, Blinkova O, Bradfute S, Brister JR, Bukreyev A, Chandran K, Chepurnov AA, Davey RA, Dietzgen RG, Doggett NA, Dolnik O, Dye JM, Enterlein S, Fenimore PW, Formenty P, Freiberg AN, Garry RF, Garza NL, Gire SK, Gonzalez JP, Griffiths A, Happi CT, Hensley LE, Herbert AS, Hevey MC, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson JC, Johnson KM, Kindrachuk J, Klenk HD, Kobinger G, Kochel TJ, Lackemeyer MG, Lackner DF, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Omilabu SA, Palacios G, Panchal RG, Park DJ, Patterson JL, Paweska JT, Peters CJ, Pettitt J, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Sabeti PC, Sealfon R, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. PMID: 25256396.
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    66. Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallogr D Biol Crystallogr. 2014 Jun; 70(Pt 6):1764-9. West BR, Hastie KM, Saphire EO. PMID: 24914986.
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    67. Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013. Arch Virol. 2014 Apr; 159(4):821-30. Bukreyev AA, Chandran K, Dolnik O, Dye JM, Ebihara H, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Saphire EO, Smither SJ, Takada A, Towner JS, Volchkov VE, Warren TK, Kuhn JH. PMID: 24122154.
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    68. Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein. Nucleic Acids Res. 2014 May; 42(9):6025-37. Olal D, Dick A, Woods VL, Liu T, Li S, Devignot S, Weber F, Saphire EO, Daumke O. PMID: 24688060.
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    69. Structure of the Reston ebolavirus VP30 C-terminal domain. Acta Crystallogr F Struct Biol Commun. 2014 Apr; 70(Pt 4):457-60. Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO. PMID: 24699737.
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    70. Lassa fever in post-conflict sierra leone. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2748. Shaffer JG, Grant DS, Schieffelin JS, Boisen ML, Goba A, Hartnett JN, Levy DC, Yenni RE, Moses LM, Fullah M, Momoh M, Fonnie M, Fonnie R, Kanneh L, Koroma VJ, Kargbo K, Ottomassathien D, Muncy IJ, Jones AB, Illick MM, Kulakosky PC, Haislip AM, Bishop CM, Elliot DH, Brown BL, Zhu H, Hastie KM, Andersen KG, Gire SK, Tabrizi S, Tariyal R, Stremlau M, Matschiner A, Sampey DB, Spence JS, Cross RW, Geisbert JB, Folarin OA, Happi CT, Pitts KR, Geske FJ, Geisbert TW, Saphire EO, Robinson JE, Wilson RB, Sabeti PC, Henderson LA, Khan SH, Bausch DG, Branco LM, Garry RF. PMID: 24651047.
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    71. Complement is activated by IgG hexamers assembled at the cell surface. Science. 2014 Mar 14; 343(6176):1260-3. Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW. PMID: 24626930.
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    72. Crystal structure of Marburg virus VP24. J Virol. 2014 May; 88(10):5859-63. Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO. PMID: 24574400.
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    73. Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Arch Virol. 2014 May; 159(5):1229-37. Kuhn JH, Bào Y, Bavari S, Becker S, Bradfute S, Brauburger K, Rodney Brister J, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. PMID: 24190508.
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    74. An update on the use of antibodies against the filoviruses. Immunotherapy. 2013 Nov; 5(11):1221-33. Saphire EO. PMID: 24188676.
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    75. Crystal structure of the nipah virus phosphoprotein tetramerization domain. J Virol. 2014 Jan; 88(1):758-62. Bruhn JF, Barnett KC, Bibby J, Thomas JM, Keegan RM, Rigden DJ, Bornholdt ZA, Saphire EO. PMID: 24155387.
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    76. Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle. Cell. 2013 Aug 15; 154(4):763-74. Bornholdt ZA, Noda T, Abelson DM, Halfmann P, Wood MR, Kawaoka Y, Saphire EO. PMID: 23953110.
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    77. Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. J Virol. 2013 Sep; 87(18):10385-8. Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO. PMID: 23824825.
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    78. Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jun; 158(6):1425-32. Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Lofts LL, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. PMID: 23358612.
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    79. Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein. Chembiochem. 2012 Nov 26; 13(17):2549-57. Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR. PMID: 23111988.
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    80. Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jan; 158(1):301-11. Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Hensley LE, Honko AN, Jahrling PB, Johnson KM, Kobinger G, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Saphire EO, Smither SJ, Swanepoel R, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Weidmann M, Nichol ST. PMID: 23001720.
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    81. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. PLoS Pathog. 2012 Sep; 8(9):e1002916. Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO. PMID: 23028316.
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    82. Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease. PLoS One. 2012; 7(8):e44211. Hastie KM, King LB, Zandonatti MA, Saphire EO. PMID: 22937163.
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    83. The ebolavirus VP24 interferon antagonist: know your enemy. Virulence. 2012 Aug 15; 3(5):440-5. Zhang AP, Abelson DM, Bornholdt ZA, Liu T, Woods VL, Saphire EO. PMID: 23076242.
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    84. Structural basis for differential neutralization of ebolaviruses. Viruses. 2012 04; 4(4):447-70. Bale S, Dias JM, Fusco ML, Hashiguchi T, Wong AC, Liu T, Keuhne AI, Li S, Woods VL, Chandran K, Dye JM, Saphire EO. PMID: 22590681.
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    85. The variety of study in the field of emerging viruses. Curr Opin Virol. 2012 Apr; 2(2):157-9. Saphire EO, Feldmann H. PMID: 22482713.
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    86. The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog. 2012 Feb; 8(2):e1002550. Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL, Saphire EO. PMID: 22383882.
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    87. Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses. Curr Opin Virol. 2012 Apr; 2(2):151-6. Hastie KM, Bale S, Kimberlin CR, Saphire EO. PMID: 22482712.
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    88. Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus. J Virol. 2012 Mar; 86(5):2809-16. Olal D, Kuehne AI, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM, Saphire EO. PMID: 22171276.
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    89. A shared structural solution for neutralizing ebolaviruses. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1424-7. Dias JM, Kuehne AI, Abelson DM, Bale S, Wong AC, Halfmann P, Muhammad MA, Fusco ML, Zak SE, Kang E, Kawaoka Y, Chandran K, Dye JM, Saphire EO. PMID: 22101933.
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    90. Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion. PLoS Negl Trop Dis. 2011 Nov; 5(11):e1395. Bale S, Liu T, Li S, Wang Y, Abelson D, Fusco M, Woods VL, Saphire EO. PMID: 22102923.
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    91. Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19365-70. Hastie KM, Liu T, Li S, King LB, Ngo N, Zandonatti MA, Woods VL, de la Torre JC, Saphire EO. PMID: 22084115.
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    92. Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change. J Virol. 2012 Jan; 86(1):364-72. Brecher M, Schornberg KL, Delos SE, Fusco ML, Saphire EO, White JM. PMID: 22031933.
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    93. Measles virus fusion shifts into gear. Nat Struct Mol Biol. 2011 Feb; 18(2):115-6. Saphire EO, Oldstone MB. PMID: 21289649.
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    94. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2396-401. Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO. PMID: 21262835.
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    95. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):314-9. Kimberlin CR, Bornholdt ZA, Li S, Woods VL, MacRae IJ, Saphire EO. PMID: 20018665.
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    96. Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein. Acta Crystallogr D Biol Crystallogr. 2009 Nov; 65(Pt 11):1162-80. Lee JE, Fusco ML, Abelson DM, Hessell AJ, Burton DR, Saphire EO. PMID: 19923712.
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    97. Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it. Curr Opin Struct Biol. 2009 Aug; 19(4):408-17. Lee JE, Saphire EO. PMID: 19559599.
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    98. An efficient platform for screening expression and crystallization of glycoproteins produced in human cells. Nat Protoc. 2009; 4(4):592-604. Lee JE, Fusco ML, Saphire EO. PMID: 19373230.
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    99. Ebolavirus glycoprotein structure and mechanism of entry. Future Virol. 2009; 4(6):621-635. Lee JE, Saphire EO. PMID: 20198110.
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    100. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008 Jul 10; 454(7201):177-82. Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO. PMID: 18615077.
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    101. Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain. J Mol Biol. 2008 Jan 04; 375(1):202-16. Lee JE, Kuehne A, Abelson DM, Fusco ML, Hart MK, Saphire EO. PMID: 18005986.
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    102. Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. J Mol Biol. 2007 Jun 08; 369(3):696-709. Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. PMID: 17445828.
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    103. Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling. J Virol. 2006 Jun; 80(11):5168-78. Cárdenas WB, Loo YM, Gale M, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF. PMID: 16698997.
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    104. gp41: HIV's shy protein. Nat Med. 2004 Feb; 10(2):133-4. Zwick MB, Saphire EO, Burton DR. PMID: 14760422.
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    105. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. J Virol. 2003 May; 77(10):5863-76. Zwick MB, Parren PW, Saphire EO, Church S, Wang M, Scott JK, Dawson PE, Wilson IA, Burton DR. PMID: 12719580.
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    106. Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. Adv Exp Med Biol. 2003; 535:55-66. Saphire EO, Stanfield RL, Crispin MD, Morris G, Zwick MB, Pantophlet RA, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. PMID: 14714888.
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    107. The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12. Adv Exp Med Biol. 2003; 535:205-18. Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM. PMID: 14714897.
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    108. Structure-based drug design. IDrugs. 2002 Jul; 5(7):658-61. Saphire EO. PMID: 14686344.
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    109. Contrasting IgG structures reveal extreme asymmetry and flexibility. J Mol Biol. 2002 May 24; 319(1):9-18. Saphire EO, Stanfield RL, Crispin MD, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. PMID: 12051932.
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    110. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J Virol. 2001 Nov; 75(22):10892-905. Zwick MB, Labrijn AF, Wang M, Spenlehauer C, Saphire EO, Binley JM, Moore JP, Stiegler G, Katinger H, Burton DR, Parren PW. PMID: 11602729.
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    111. Listening for viral infection. Nat Biotechnol. 2001 Sep; 19(9):823-4. Saphire EO, Parren PW. PMID: 11533636.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    112. Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science. 2001 Aug 10; 293(5532):1155-9. Saphire EO, Parren PW, Pantophlet R, Zwick MB, Morris GM, Rudd PM, Dwek RA, Stanfield RL, Burton DR, Wilson IA. PMID: 11498595.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansCells
    113. Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. Acta Crystallogr D Biol Crystallogr. 2001 Jan; 57(Pt 1):168-71. Saphire EO, Parren PW, Barbas CF, Burton DR, Wilson IA. PMID: 11134947.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    114. gp120: Biologic aspects of structural features. Annu Rev Immunol. 2001; 19:253-74. Poignard P, Saphire EO, Parren PW, Burton DR. PMID: 11244037.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    115. A model for neutralization of viruses based on antibody coating of the virion surface. Curr Top Microbiol Immunol. 2001; 260:109-43. Burton DR, Saphire EO, Parren PW. PMID: 11443871.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
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