Erica Saphire

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Consortium for Immunotherapeutics against Emerging Viral Threats
    NIH U19AI142790May 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Rationally Designed Pan-Ebolavirus Vaccine
    NIH R01AI132204Jun 20, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Function and assembly of the Ebola virus nucleocapsid
    NIH R01AI118016Mar 1, 2016 - Aug 31, 2020
    Role: Principal Investigator
    Function and assembly of the Ebola virus nucleocapsid
    NIH R56AI118016Mar 1, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Interpreting a hard-won structure of the arenavirus prefusion glycoprotein
    NIH R21AI116112Dec 1, 2014 - Nov 30, 2017
    Role: Principal Investigator
    Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers
    NIH U19AI109762Mar 15, 2014 - Jun 28, 2019
    Role: Principal Investigator
    Analysis of immunotherapeutics to native Marburg virus epitopes
    NIH R01AI089498Jul 1, 2010 - Dec 31, 2015
    Role: Principal Investigator
    NIH R01AI081982Dec 15, 2009 - May 31, 2015
    Role: Principal Investigator
    Immunotherapeutics against Marburg: Development, structural &functional anaylsis
    NIH U01AI082156Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Immunotherapeutics vs Ebola Sudan: Development, Structural &Functional Analysis
    NIH U01AI070530Sep 15, 2006 - Aug 31, 2011
    Role: Principal Investigator
    NIH R01AI067927Jul 15, 2006 - Jun 30, 2014
    Role: Principal Investigator
    Structural Studies of Ebola Viral Pathogenesis
    NIH R21AI053423Sep 15, 2002 - Aug 31, 2004
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses. Res Sq. 2024 Mar 26. Bukreyev A, Meyer M, Gunn B, Pietzsch C, Subramani C, Saphire E, Crowe J, Alter G, Himansu S, Carfi A. PMID: 38585993; PMCID: PMC10996797.
      View in: PubMed   Mentions:
    2. Protein complex heterogeneity and topology revealed by electron capture charge reduction and surface induced dissociation. bioRxiv. 2024 Mar 09. Shaw J, Harvey S, Du C, Xu Z, Olmedillas E, Saphire EO, Wysocki VH. PMID: 38496594; PMCID: PMC10942452.
      View in: PubMed   Mentions:
    3. Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Res Sq. 2023 Dec 22. Saphire E, Salie ZL, Ke Z, Halfmann P, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel S, Hariharan C, Norris M, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook M, Doranz B, Crozier I, Hastie K, Kawaoka Y, Branco L, Kuhn J, Briggs J, Worwa G, Davis C, Ahmed R. PMID: 38196595; PMCID: PMC10775387.
      View in: PubMed   Mentions:
    4. Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation. bioRxiv. 2023 Dec 15. Olmedillas E, Rajamanickam RR, Avalos RD, Sosa FA, Zandonatti MA, Harkins SS, Shresta S, Hastie KM, Saphire EO. PMID: 38168261; PMCID: PMC10760097.
      View in: PubMed   Mentions:
    5. Identification of mouse CD4+ T cell epitopes in SARS-CoV-2 BA.1 spike and nucleocapsid for use in peptide:MHCII tetramers. bioRxiv. 2023 Nov 17. Moreno LB, de Albuquerque JB, Neary JM, Nguyen T, Hastie KM, Landeras-Bueno S, Hariharan C, Nathan A, Getz MA, Gayton AC, Khatri A, Gaiha GD, Saphire EO, Luster AD, Moon JJ. PMID: 38014059; PMCID: PMC10680761.
      View in: PubMed   Mentions:
    6. The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus. Cell Rep. 2023 11 28; 42(11):113366. Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO. PMID: 37938974.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology. Nat Commun. 2023 11 03; 14(1):7062. Streblow DN, Hirsch AJ, Stanton JJ, Lewis AD, Colgin L, Hessell AJ, Kreklywich CN, Smith JL, Sutton WF, Chauvin D, Woo J, Bimber BN, LeBlanc CN, Acharya SN, O'Roak BJ, Sardar H, Sajadi MM, Tehrani ZR, Walter MR, Martinez-Sobrido L, Kobie JJ, Reader RJ, Olstad KJ, Hobbs TR, Saphire EO, Schendel SL, Carnahan RH, Knoch J, Branco LM, Crowe JE, Van Rompay KKA, Lovalenti P, Forthal DN, Haigwood NL. PMID: 37923717; PMCID: PMC10624670.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. The Arenaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype Pathogens. J Infect Dis. 2023 10 18; 228(Suppl 6):S359-S375. Hastie KM, Melnik LI, Cross RW, Klitting RM, Andersen KG, Saphire EO, Garry RF. PMID: 37849403; PMCID: PMC10582522.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. The in situ Structural Approach to Reveal the Filovirus Budding Mechanism. Microsc Microanal. 2023 Jul 22; 29(29 Suppl 1):900-901. Watanabe R, Saphire EO. PMID: 37613812.
      View in: PubMed   Mentions:    Fields:    
    10. Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories. Nat Commun. 2023 07 13; 14(1):4159. Fang J, Castillon G, Phan S, McArdle S, Hariharan C, Adams A, Ellisman MH, Deniz AA, Saphire EO. PMID: 37443171; PMCID: PMC10345124.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications. Structure. 2023 09 07; 31(9):1038-1051.e7. Werner AD, Schauflinger M, Norris MJ, Klüver M, Trodler A, Herwig A, Brandstädter C, Dillenberger M, Klebe G, Heine A, Saphire EO, Becker K, Becker S. PMID: 37392738.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. B cell and antibody targeting of transplant alloantigen epitopes is supported by both self and allo-recognition. bioRxiv. 2023 Jun 24. Killian JT, King RG, Kizziah JL, Fucile CF, Diaz-Avalos R, Qiu S, Silva-Sanchez A, Mousseau BJ, Macon KJ, Callahan AR, Yang G, Hossain ME, Akther J, Houp JA, Rosenblum FD, Porrett PM, Ong SC, Kumar V, Saphire EO, Kearney JF, Randall TD, Rosenberg AF, Green TJ, Lund FE. PMID: 37034637; PMCID: PMC10081326.
      View in: PubMed   Mentions:
    13. ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19. Nat Immunol. 2023 07; 24(7):1161-1172. Kaplonek P, Cizmeci D, Kwatra G, Izu A, Lee JS, Bertera HL, Fischinger S, Mann C, Amanat F, Wang W, Koen AL, Fairlie L, Cutland CL, Ahmed K, Dheda K, Barnabas SL, Bhorat QE, Briner C, Krammer F, Saphire EO, Gilbert SC, Lambe T, Pollard AJ, Nunes M, Wuhrer M, Lauffenburger DA, Madhi SA, Alter G. PMID: 37322179; PMCID: PMC10307634.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    14. Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates. Cell Rep. 2023 04 25; 42(4):112402. Gunn BM, McNamara RP, Wood L, Taylor S, Devadhasan A, Guo W, Das J, Nilsson A, Shurtleff A, Dubey S, Eichberg M, Suscovich TJ, Saphire EO, Lauffenburger D, Coller BA, Simon JK, Alter G. PMID: 37061918; PMCID: PMC10576837.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep. 2023 05 30; 42(5):112421. Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Saphire EO. PMID: 37083327; PMCID: PMC10083196.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes. Cell Rep. 2023 04 25; 42(4):112370. Chen EC, Gilchuk P, Zost SJ, Ilinykh PA, Binshtein E, Huang K, Myers L, Bonissone S, Day S, Kona CR, Trivette A, Reidy JX, Sutton RE, Gainza C, Diaz S, Williams JK, Selverian CN, Davidson E, Saphire EO, Doranz BJ, Castellana N, Bukreyev A, Carnahan RH, Crowe JE. PMID: 37029928; PMCID: PMC10556194.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol. 2023 04 20; 30(4):403-411.e4. Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO. PMID: 36990092.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    18. SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse model. Antiviral Res. 2023 04; 212:105580. Alves RPDS, Wang YT, Mikulski Z, McArdle S, Shafee N, Valentine KM, Miller R, Verma SK, Batiz FAS, Maule E, Nguyen MN, Timis J, Mann C, Zandonatti M, Alarcon S, Rowe J, Kronenberg M, Weiskopf D, Sette A, Hastie K, Saphire EO, Festin S, Kim K, Shresta S. PMID: 36940916; PMCID: PMC10027296.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Coronavirus Immunotherapeutic Consortium Database. Database (Oxford). 2023 02 10; 2023. Mahita J, Ha B, Gambiez A, Schendel SL, Li H, Hastie KM, Dennison SM, Li K, Kuzmina N, Periasamy S, Bukreyev A, Munt JE, Osei-Twum M, Atyeo C, Overton JA, Vita R, Guzman-Orozco H, Mendes M, Kojima M, Halfmann PJ, Kawaoka Y, Alter G, Gagnon L, Baric RS, Tomaras GD, Germann T, Bedinger D, Greenbaum JA, Saphire EO, Peters B. PMID: 36763096; PMCID: PMC9913043.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Structure of the Inmazeb cocktail and resistance to Ebola virus escape. Cell Host Microbe. 2023 02 08; 31(2):260-272.e7. Rayaprolu V, Fulton BO, Rafique A, Arturo E, Williams D, Hariharan C, Callaway H, Parvate A, Schendel SL, Parekh D, Hui S, Shaffer K, Pascal KE, Wloga E, Giordano S, Negron N, Ni M, Copin R, Atwal GS, Franklin M, Boytz RM, Donahue C, Davey R, Baum A, Kyratsous CA, Saphire EO. PMID: 36708708; PMCID: PMC10375381.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium. Cell Rep. 2023 01 31; 42(1):112014. Callaway HM, Hastie KM, Schendel SL, Li H, Yu X, Shek J, Buck T, Hui S, Bedinger D, Troup C, Dennison SM, Li K, Alpert MD, Bailey CC, Benzeno S, Bonnevier JL, Chen JQ, Chen C, Cho H, Crompton PD, Dussupt V, Entzminger KC, Ezzyat Y, Fleming JK, Geukens N, Gilbert AE, Guan Y, Han X, Harvey CJ, Hatler JM, Howie B, Hu C, Huang A, Imbrechts M, Jin A, Kamachi N, Keitany G, Klinger M, Kolls JK, Krebs SJ, Li T, Luo F, Maruyama T, Meehl MA, Mendez-Rivera L, Musa A, Okumura CJ, Rubin BER, Sato AK, Shen M, Singh A, Song S, Tan J, Trimarchi JM, Upadhyay DP, Wang Y, Yu L, Yuan TZ, Yusko E, Peters B, Tomaras G, Saphire EO. PMID: 36681898; PMCID: PMC9834171.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Antibodies as drugs-a Keystone Symposia report. Ann N Y Acad Sci. 2023 01; 1519(1):153-166. Cable J, Saphire EO, Hayday AC, Wiltshire TD, Mousa JJ, Humphreys DP, Breij ECW, Bruhns P, Broketa M, Furuya G, Hauser BM, Mahévas M, Carfi A, Cantaert T, Kwong PD, Tripathi P, Davis JH, Brewis N, Keyt BA, Fennemann FL, Dussupt V, Sivasubramanian A, Kim PM, Rawi R, Richardson E, Leventhal D, Wolters RM, Geuijen CAW, Sleeman MA, Pengo N, Donnellan FR. PMID: 36382536; PMCID: PMC10103175.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey. Commun Biol. 2022 11 09; 5(1):1204. Worwa G, Cooper TK, Yeh S, Shantha JG, Hischak AMW, Klim SE, Byrum R, Kurtz JR, Anthony SM, Aiosa NM, Ragland D, Lee JH, Claire MS, Davis C, Ahmed R, Holbrook MR, Kuhn JH, Saphire EO, Crozier I. PMID: 36352100; PMCID: PMC9644391.
      View in: PubMed   Mentions: 3  Translation:HumansAnimalsCells
    24. A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. Sci Transl Med. 2022 10 26; 14(668):eabq0991. Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO. PMID: 36288283; PMCID: PMC10084740.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern. Nat Commun. 2022 10 03; 13(1):5814. Chang MR, Tomasovic L, Kuzmina NA, Ronk AJ, Byrne PO, Johnson R, Storm N, Olmedillas E, Hou YJ, Schäfer A, Leist SR, Tse LV, Ke H, Coherd C, Nguyen K, Kamkaew M, Honko A, Zhu Q, Alter G, Saphire EO, McLellan JS, Griffiths A, Baric RS, Bukreyev A, Marasco WA. PMID: 36192374; PMCID: PMC9528872.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. Lessons from the pandemic: Responding to emerging zoonotic viral diseases-a Keystone Symposia report. Ann N Y Acad Sci. 2022 12; 1518(1):209-225. Cable J, Fauci A, Dowling WE, Günther S, Bente DA, Yadav PD, Madoff LC, Wang LF, Arora RK, Van Kerkhove M, Chu MC, Jaenisch T, Epstein JH, Frost SDW, Bausch DG, Hensley LE, Bergeron É, Sitaras I, Gunn MD, Geisbert TW, Muñoz-Fontela C, Krammer F, de Wit E, Nordenfelt P, Saphire EO, Gilbert SC, Corbett KS, Branco LM, Baize S, van Doremalen N, Krieger MA, Clemens SAC, Hesselink R, Hartman D. PMID: 36183296; PMCID: PMC9538336.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    27. Glycan shield of the ebolavirus envelope glycoprotein GP. Commun Biol. 2022 08 04; 5(1):785. Peng W, Rayaprolu V, Parvate AD, Pronker MF, Hui S, Parekh D, Shaffer K, Yu X, Saphire EO, Snijder J. PMID: 35927436; PMCID: PMC9352669.
      View in: PubMed   Mentions: 4  Translation:Cells
    28. Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization. Sci Adv. 2022 Jul 22; 8(29):eabn1440. Norris MJ, Husby ML, Kiosses WB, Yin J, Saxena R, Rennick LJ, Heiner A, Harkins SS, Pokhrel R, Schendel SL, Hastie KM, Landeras-Bueno S, Salie ZL, Lee B, Chapagain PP, Maisner A, Duprex WP, Stahelin RV, Saphire EO. PMID: 35857835; PMCID: PMC9299542.
      View in: PubMed   Mentions: 4     Fields:    
    29. Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2201208119. Fang J, Pietzsch C, Witwit H, Tsaprailis G, Crynen G, Cho KF, Ting AY, Bukreyev A, Saphire EO, de la Torre JC. PMID: 35858434; PMCID: PMC9340056.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera. Antiviral Res. 2022 08; 204:105370. Seephetdee C, Bhukhai K, Buasri N, Leelukkanaveera P, Lerdwattanasombat P, Manopwisedjaroen S, Phueakphud N, Kuhaudomlarp S, Olmedillas E, Saphire EO, Thitithanyanont A, Hongeng S, Wongtrakoongate P. PMID: 35772601; PMCID: PMC9235288.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Neutralizing Antibodies against Lassa Virus Lineage I. mBio. 2022 08 30; 13(4):e0127822. Buck TK, Enriquez AS, Schendel SL, Zandonatti MA, Harkins SS, Li H, Moon-Walker A, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM. PMID: 35730904; PMCID: PMC9426445.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Sci Adv. 2022 Jun 17; 8(24):eabp9151. Callaway HM, Zyla D, Larrous F, de Melo GD, Hastie KM, Avalos RD, Agarwal A, Corti D, Bourhy H, Saphire EO. PMID: 35714192; PMCID: PMC9205594.
      View in: PubMed   Mentions: 10     Fields:    
    33. Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies. Cell Rep. 2022 05 24; 39(8):110841. Enriquez AS, Buck TK, Li H, Norris MJ, Moon-Walker A, Zandonatti MA, Harkins SS, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM. PMID: 35613585; PMCID: PMC9258627.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Sci Transl Med. 2022 05 18; 14(645):eabm2311. Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G. PMID: 35348368; PMCID: PMC8995030.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCellsPHPublic Health
    35. Inducing broad-based immunity against viruses with pandemic potential. Immunity. 2022 05 10; 55(5):738-748. Sette A, Saphire EO. PMID: 35545026; PMCID: PMC10286218.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    36. Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication. Cell Rep. 2022 03 22; 38(12):110544. Fang J, Pietzsch C, Tsaprailis G, Crynen G, Cho KF, Ting AY, Bukreyev A, de la Torre JC, Saphire EO. PMID: 35320713; PMCID: PMC10496643.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. Development and Structural Analysis of Antibody Therapeutics for Filoviruses. Pathogens. 2022 Mar 18; 11(3). Yu X, Saphire EO. PMID: 35335698; PMCID: PMC8949092.
      View in: PubMed   Mentions: 4  
    38. Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses. Cell. 2022 03 17; 185(6):995-1007.e18. Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO. PMID: 35303429; PMCID: PMC10204903.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Stopping pandemics before they start: Lessons learned from SARS-CoV-2. Science. 2022 Mar 11; 375(6585):1133-1139. Edwards AM, Baric RS, Saphire EO, Ulmer JB. PMID: 35271333.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCellsPHPublic Health
    40. Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo. PLoS Negl Trop Dis. 2022 03; 16(3):e0010167. Shaffer KCL, Hui S, Bratcher A, King LB, Mutombe R, Kavira N, Kompany JP, Tambu M, Musene K, Mukadi P, Mbala P, Gadoth A, West BR, Ilunga BK, Kaba D, Muyembe-Tanfum JJ, Hoff NA, Rimoin AW, Saphire EO. PMID: 35255093; PMCID: PMC8929691.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    41. CD164 is a host factor for lymphocytic choriomeningitis virus entry. Proc Natl Acad Sci U S A. 2022 03 08; 119(10):e2119676119. Bakkers MJG, Moon-Walker A, Herlo R, Brusic V, Stubbs SH, Hastie KM, Saphire EO, Kirchhausen TL, Whelan SPJ. PMID: 35235462; PMCID: PMC8915965.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. A Manhattan Project against COVID. FASEB J. 2022 02; 36(2):e22117. Scolnick EM, Saphire EO. PMID: 35060642.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern. Immunity. 2022 02 08; 55(2):355-365.e4. Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC, Kang J, Burke JS, Shin SA, Dayal D, Martin P, Mann C, Amanat F, Julg B, Nilles EJ, Musk ER, Menon AS, Krammer F, Saphire EO, Alter G. PMID: 35090580; PMCID: PMC8733218.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsPHPublic Health
    44. Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries. MAbs. 2022 Jan-Dec; 14(1):2002236. Yuan TZ, Garg P, Wang L, Willis JR, Kwan E, Hernandez AGL, Tuscano E, Sever EN, Keane E, Soto C, Mucker EM, Fouch ME, Davidson E, Doranz BJ, Kailasan S, Aman MJ, Li H, Hooper JW, Saphire EO, Crowe JE, Liu Q, Axelrod F, Sato AK. PMID: 34967699; PMCID: PMC8726723.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Novel attempts launched toward universal Sarbecovirus vaccine. Cell Res. 2021 12; 31(12):1226-1227. Li H, Saphire EO. PMID: 34433899; PMCID: PMC8385477.
      View in: PubMed   Mentions:    Fields:    
    46. SARS-CoV-2 infection generates tissue-localized immunological memory in humans. Sci Immunol. 2021 Nov 19; 6(65):eabl9105. Poon MML, Rybkina K, Kato Y, Kubota M, Matsumoto R, Bloom NI, Zhang Z, Hastie KM, Grifoni A, Weiskopf D, Wells SB, Ural BB, Lam N, Szabo PA, Dogra P, Lee YS, Gray JI, Bradley MC, Brusko MA, Brusko TM, Saphire EO, Connors TJ, Sette A, Crotty S, Farber DL. PMID: 34618554; PMCID: PMC8626868.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
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    54. Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form. Cell Rep. 2021 04 13; 35(2):108986. Landeras-Bueno S, Wasserman H, Oliveira G, VanAernum ZL, Busch F, Salie ZL, Wysocki VH, Andersen K, Saphire EO. PMID: 33852858; PMCID: PMC8568338.
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    64. Lifted Up from Lockdown. Cell. 2020 10 01; 183(1):1-3. Arturo EC, Saphire EO. PMID: 33007260; PMCID: PMC7528821.
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    65. Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages. Sci Rep. 2020 09 29; 10(1):16030. Heinrich ML, Boisen ML, Nelson DKS, Bush DJ, Cross RW, Koval AP, Hoffmann AR, Beddingfield BJ, Hastie KM, Rowland MM, Aimukanova I, Koval S, Lathigra R, Borisevich V, Momoh M, Sandi JD, Goba A, Odia L, Baimba F, Aiyepada JO, Ebo B, Eromon P, Ugwu C, Folarin O, Olumade T, Onyechi MN, Etafo J, Adeyemi R, Ella EE, Aminu M, Gomerep SS, Eke MA, Ogunsanya O, Akpede GO, Asogun DO, Okogbenin SA, Okokhere PO, Holst J, Shaffer JG, Schieffelin JS, Geisbert TW, Saphire EO, Happi CT, Grant DS, Garry RF, Branco LM. PMID: 32994446; PMCID: PMC7525497.
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    66. SnapShot: Enveloped Virus Entry. Cell. 2020 08 06; 182(3):786-786.e1. Mercer J, Lee JE, Saphire EO, Freeman SA. PMID: 32763187; PMCID: PMC7409976.
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    67. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell. 2020 08 20; 182(4):812-827.e19. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B, Hastie KM, Parker MD, Partridge DG, Evans CM, Freeman TM, de Silva TI, Sheffield COVID-19 Genomics Group, McDanal C, Perez LG, Tang H, Moon-Walker A, Whelan SP, LaBranche CC, Saphire EO, Montefiori DC. PMID: 32697968; PMCID: PMC7332439.
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    69. Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. Cell Host Microbe. 2020 06 10; 27(6):976-991.e11. Ilinykh PA, Huang K, Santos RI, Gilchuk P, Gunn BM, Karim MM, Liang J, Fouch ME, Davidson E, Parekh DV, Kimble JB, Pietzsch CA, Meyer M, Kuzmina NA, Zeitlin L, Saphire EO, Alter G, Crowe JE, Bukreyev A. PMID: 32320678; PMCID: PMC7292764.
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    70. Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization. Immunity. 2020 02 18; 52(2):388-403.e12. Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE. PMID: 32023489; PMCID: PMC7111202.
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    71. Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111. Viruses. 2020 01 15; 12(1). Lin AE, Diehl WE, Cai Y, Finch CL, Akusobi C, Kirchdoerfer RN, Bollinger L, Schaffner SF, Brown EA, Saphire EO, Andersen KG, Kuhn JH, Luban J, Sabeti PC. PMID: 31952352; PMCID: PMC7019320.
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    72. A glimpse into immune responses evolving against Ebola virus. Nat Med. 2019 10; 25(10):1470-1471. Saphire EO. PMID: 31591604.
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    73. Diverse Morphology and Structural Features of Old and New World Hantaviruses. Viruses. 2019 09 16; 11(9). Parvate A, Williams EP, Taylor MK, Chu YK, Lanman J, Saphire EO, Jonsson CB. PMID: 31527500; PMCID: PMC6783877.
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    74. Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization. Cell. 2019 08 08; 178(4):1004-1015.e14. Hastie KM, Cross RW, Harkins SS, Zandonatti MA, Koval AP, Heinrich ML, Rowland MM, Robinson JE, Geisbert TW, Garry RF, Branco LM, Saphire EO. PMID: 31398326; PMCID: PMC6814208.
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    75. Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment. mBio. 2019 07 23; 10(4). Landeras-Bueno S, Oda SI, Norris MJ, Li Salie Z, Guenaga J, Wyatt RT, Saphire EO. PMID: 31337716; PMCID: PMC6650547.
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    76. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. 2019 05 30; 177(6):1566-1582.e17. Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. PMID: 31104840; PMCID: PMC6908968.
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    77. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex. Acta Crystallogr F Struct Biol Commun. 2019 May 01; 75(Pt 5):340-347. Kirchdoerfer RN, Saphire EO, Ward AB. PMID: 31045563; PMCID: PMC6497097.
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    78. Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun. 2019 04 17; 10(1):1788. King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE, Saphire EO. PMID: 30996276; PMCID: PMC6470140.
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    79. Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection. J Virol. 2019 04 15; 93(8). Williamson LE, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz BJ, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE. PMID: 30728263; PMCID: PMC6450119.
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    81. A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function. Structure. 2019 04 02; 27(4):660-668.e4. Bruhn JF, Hotard AL, Spiropoulou CF, Lo MK, Saphire EO. PMID: 30799076; PMCID: PMC6690496.
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    82. Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein. J Infect Dis. 2019 01 09; 219(3):415-419. Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO. PMID: 30203042; PMCID: PMC6325343.
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    83. In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model. Cell Rep. 2018 11 13; 25(7):1982-1993.e4. Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, Kobinger GP, He S, Qiu X, Kobasa D, Humeau L, Sardesai NY, Ahmed R, Weiner DB. PMID: 30428362; PMCID: PMC6319964.
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    85. Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. mBio. 2018 09 11; 9(5). West BR, Moyer CL, King LB, Fusco ML, Milligan JC, Hui S, Saphire EO. PMID: 30206174; PMCID: PMC6134094.
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    86. Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors. Cell Rep. 2018 08 14; 24(7):1816-1829. Meyer M, Yoshida A, Ramanathan P, Saphire EO, Collins PL, Crowe JE, Samal S, Bukreyev A. PMID: 30110638; PMCID: PMC6145141.
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    87. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell. 2018 08 09; 174(4):938-952.e13. Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe JE, Davis CW, Georgiou G, Krammer F, Kyratsous CA, Lai JR, Nykiforuk C, Pauly MH, Rijal P, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM, Viral Hemorrhagic Fever Immunotherapeutic Consortium. PMID: 30096313; PMCID: PMC6102396.
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    88. A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host Microbe. 2018 08 08; 24(2):221-233.e5. Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, Lai J, Chandran K, Zeitlin L, Crowe JE, Lauffenburger D, Kawaoka Y, Kobinger GP, Andersen KG, Dye JM, Saphire EO, Alter G. PMID: 30092199; PMCID: PMC6298217.
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    89. Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity. 2018 08 21; 49(2):363-374.e10. Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE. PMID: 30029854; PMCID: PMC6104738.
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    90. The structural basis for filovirus neutralization by monoclonal antibodies. Curr Opin Immunol. 2018 08; 53:196-202. King LB, West BR, Schendel SL, Saphire EO. PMID: 29940415; PMCID: PMC6141344.
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    91. Lassa virus glycoprotein: stopping a moving target. Curr Opin Virol. 2018 08; 31:52-58. Hastie KM, Saphire EO. PMID: 29843991; PMCID: PMC6193841.
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    92. Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region. Nat Microbiol. 2018 06; 3(6):670-677. Flyak AI, Kuzmina N, Murin CD, Bryan C, Davidson E, Gilchuk P, Gulka CP, Ilinykh PA, Shen X, Huang K, Ramanathan P, Turner H, Fusco ML, Lampley R, Kose N, King H, Sapparapu G, Doranz BJ, Ksiazek TG, Wright DW, Saphire EO, Ward AB, Bukreyev A, Crowe JE. PMID: 29736037; PMCID: PMC6030461.
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    93. Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever. Sci Rep. 2018 04 12; 8(1):5939. Boisen ML, Hartnett JN, Shaffer JG, Goba A, Momoh M, Sandi JD, Fullah M, Nelson DKS, Bush DJ, Rowland MM, Heinrich ML, Koval AP, Cross RW, Barnes KG, Lachenauer AE, Lin AE, Nekoui M, Kotliar D, Winnicki SM, Siddle KJ, Gbakie M, Fonnie M, Koroma VJ, Kanneh L, Kulakosky PC, Hastie KM, Wilson RB, Andersen KG, Folarin OO, Happi CT, Sabeti PC, Geisbert TW, Saphire EO, Khan SH, Grant DS, Schieffelin JS, Branco LM, Garry RF. PMID: 29651117; PMCID: PMC5897328.
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    94. A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine. J Biol Chem. 2018 03 02; 293(9):3335-3349. Del Vecchio K, Frick CT, Gc JB, Oda SI, Gerstman BS, Saphire EO, Chapagain PP, Stahelin RV. PMID: 29348171; PMCID: PMC5836117.
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    95. The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe. 2018 Jan 10; 23(1):101-109.e4. King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE, Saphire EO. PMID: 29324225; PMCID: PMC5772738.
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    96. Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure. 2017 12 05; 25(12):1820-1828.e2. Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE, Meiler J. PMID: 29153506; PMCID: PMC5718948.
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    97. Structural basis for antibody-mediated neutralization of Lassa virus. Science. 2017 06 02; 356(6341):923-928. Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO. PMID: 28572385; PMCID: PMC6007842.
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    98. How to turn competitors into collaborators. Nature. 2017 01 18; 541(7637):283-285. Saphire EO, Dye JM, Kobinger GP, Zeitlin L, Chandran K, Garry RF. PMID: 28102273.
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    99. Crystal Structure of the Marburg Virus VP35 Oligomerization Domain. J Virol. 2017 Jan 15; 91(2). Bruhn JF, Kirchdoerfer RN, Urata SM, Li S, Tickle IJ, Bricogne G, Saphire EO. PMID: 27847355; PMCID: PMC5215338.
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    100. Filovirus Structural Biology: The Molecules in the Machine. Curr Top Microbiol Immunol. 2017; 411:381-417. Kirchdoerfer RN, Wasserman H, Amarasinghe GK, Saphire EO. PMID: 28795188.
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    101. The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis. PLoS Pathog. 2016 Oct; 12(10):e1005937. Kirchdoerfer RN, Moyer CL, Abelson DM, Saphire EO. PMID: 27755595; PMCID: PMC5068707.
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    102. A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses. Science. 2016 10 21; 354(6310):350-354. Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K. PMID: 27608667; PMCID: PMC5647781.
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    103. Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection. J Infect Dis. 2016 10 15; 214(suppl 3):S210-S217. Cross RW, Boisen ML, Millett MM, Nelson DS, Oottamasathien D, Hartnett JN, Jones AB, Goba A, Momoh M, Fullah M, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Brown BL, Pham H, Rowland MM, Agans KN, Geisbert JB, Heinrich ML, Kulakosky PC, Shaffer JG, Schieffelin JS, Kargbo B, Gbetuwa M, Gevao SM, Wilson RB, Saphire EO, Pitts KR, Khan SH, Grant DS, Geisbert TW, Branco LM, Garry RF. PMID: 27587634; PMCID: PMC5050482.
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    104. Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. Nat Microbiol. 2016 Aug 08; 1(9):16128. Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB. PMID: 27562261; PMCID: PMC5003320.
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    105. More than Meets the Eye: Hidden Structures in the Proteome. Annu Rev Virol. 2016 09 29; 3(1):373-386. Wasserman H, Saphire EO. PMID: 27482901.
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    106. An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. J Infect Dis. 2016 10 15; 214(suppl 3):S110-S121. Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF, Viral Hemorrhagic Fever Consortium. PMID: 27402779; PMCID: PMC5050470.
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    107. Feverish Quest for Ebola Immunotherapy: Straight or Cocktail? Trends Microbiol. 2016 09; 24(9):684-686. Saphire EO, Aman MJ. PMID: 27338027.
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    108. Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. Nat Commun. 2016 05 10; 7:11544. Robinson JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H, Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, Rowland MM, Heinrich ML, Martínez-Sobrido L, Cheng B, de la Torre JC, Andersen KG, Goba A, Momoh M, Fullah M, Gbakie M, Kanneh L, Koroma VJ, Fonnie R, Jalloh SC, Kargbo B, Vandi MA, Gbetuwa M, Ikponmwosa O, Asogun DA, Okokhere PO, Follarin OA, Schieffelin JS, Pitts KR, Geisbert JB, Kulakoski PC, Wilson RB, Happi CT, Sabeti PC, Gevao SM, Khan SH, Grant DS, Geisbert TW, Saphire EO, Branco LM, Garry RF. PMID: 27161536; PMCID: PMC4866400.
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    109. Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site. Cell Rep. 2016 05 17; 15(7):1514-1526. Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, Kroeker A, Vu H, Herbert AS, Fusco ML, Nyakatura EK, Lai JR, Keck ZY, Foung SKH, Saphire EO, Zeitlin L, Ward AB, Chandran K, Doranz BJ, Kobinger GP, Dye JM, Aman MJ. PMID: 27160900; PMCID: PMC4871745.
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    110. Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV. Nat Struct Mol Biol. 2016 06; 23(6):513-521. Hastie KM, Igonet S, Sullivan BM, Legrand P, Zandonatti MA, Robinson JE, Garry RF, Rey FA, Oldstone MB, Saphire EO. PMID: 27111888; PMCID: PMC4945123.
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    111. Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z. J Virol. 2016 May; 90(9):4556-62. Hastie KM, Zandonatti M, Liu T, Li S, Woods VL, Saphire EO. PMID: 26912609; PMCID: PMC4836352.
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    112. Two-mAb cocktail protects macaques against the Makona variant of Ebola virus. Sci Transl Med. 2016 Mar 09; 8(329):329ra33. Qiu X, Audet J, Lv M, He S, Wong G, Wei H, Luo L, Fernando L, Kroeker A, Fausther Bovendo H, Bello A, Li F, Ye P, Jacobs M, Ippolito G, Saphire EO, Bi S, Shen B, Gao GF, Zeitlin L, Feng J, Zhang B, Kobinger GP. PMID: 26962157; PMCID: PMC5814125.
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    113. Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies. mBio. 2016 Feb 23; 7(1):e02154-15. Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EO. PMID: 26908579; PMCID: PMC4791852.
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    114. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. Science. 2016 Mar 04; 351(6277):1078-83. Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM. PMID: 26912366; PMCID: PMC4900763.
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    115. Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Cell. 2016 Jan 28; 164(3):392-405. Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE. PMID: 26806128; PMCID: PMC4733404.
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    116. Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression. J Virol. 2016 02 15; 90(4):1839-48. Oda S, Noda T, Wijesinghe KJ, Halfmann P, Bornholdt ZA, Abelson DM, Armbrust T, Stahelin RV, Kawaoka Y, Saphire EO. PMID: 26656687; PMCID: PMC4733994.
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    117. Potent Antibody Protection against an Emerging Alphavirus Threat. Cell. 2015 Nov 19; 163(5):1053-1054. Kielian M, Saphire EO. PMID: 26590413.
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    118. Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses. J Virol. 2016 01 01; 90(1):266-78. Holtsberg FW, Shulenin S, Vu H, Howell KA, Patel SJ, Gunn B, Karim M, Lai JR, Frei JC, Nyakatura EK, Zeitlin L, Douglas R, Fusco ML, Froude JW, Saphire EO, Herbert AS, Wirchnianski AS, Lear-Rooney CM, Alter G, Dye JM, Glass PJ, Warfield KL, Aman MJ. PMID: 26468533; PMCID: PMC4702560.
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    119. Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. PLoS Pathog. 2015 Oct; 11(10):e1005212. Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, Nykiforuk C, Aman MJ, Berry JD, Saphire EO. PMID: 26452225; PMCID: PMC4599913.
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    120. Swift antibodies to counter emerging viruses. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10082-3. Burton DR, Saphire EO. PMID: 26261336; PMCID: PMC4547222.
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    121. Development of Prototype Filovirus Recombinant Antigen Immunoassays. J Infect Dis. 2015 Oct 01; 212 Suppl 2:S359-67. Boisen ML, Oottamasathien D, Jones AB, Millett MM, Nelson DS, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Hartnett JN, Rowland MM, Heinrich ML, Akdag M, Goba A, Momoh M, Fullah M, Baimba F, Gbakie M, Safa S, Fonnie R, Kanneh L, Cross RW, Geisbert JB, Geisbert TW, Kulakosky PC, Grant DS, Shaffer JG, Schieffelin JS, Wilson RB, Saphire EO, Branco LM, Garry RF, Khan SH, Pitts KR, Viral Hemorrhagic Fever Consortium. PMID: 26232440; PMCID: PMC4564556.
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    122. Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. PLoS Pathog. 2015 Jun; 11(6):e1005016. Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, Nykiforuk C, Aman MJ, Berry JD, Berry J, Saphire EO. PMID: 26115029; PMCID: PMC4482612.
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    123. Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex. Cell Rep. 2015 Jul 07; 12(1):140-149. Kirchdoerfer RN, Abelson DM, Li S, Wood MR, Saphire EO. PMID: 26119732; PMCID: PMC4500542.
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    124. New Advances in the Effort against Ebola. Cell Host Microbe. 2015 May 13; 17(5):545-7. Saphire EO. PMID: 25974296.
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    125. High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus. J Infect Dis. 2015 Oct 01; 212 Suppl 2:S167-71. Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO. PMID: 25957961; PMCID: PMC4564533.
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    126. Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell. 2015 Feb 26; 160(5):904-912. Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO. PMID: 25723165; PMCID: PMC4344967.
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    127. Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 2015 Feb 26; 160(5):893-903. Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, Crowe JE. PMID: 25723164; PMCID: PMC4344968.
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    128. Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak. Viral Immunol. 2015 Feb; 28(1):19-31. Boisen ML, Schieffelin JS, Goba A, Oottamasathien D, Jones AB, Shaffer JG, Hastie KM, Hartnett JN, Momoh M, Fullah M, Gabiki M, Safa S, Zandonatti M, Fusco M, Bornholdt Z, Abelson D, Gire SK, Andersen KG, Tariyal R, Stremlau M, Cross RW, Geisbert JB, Pitts KR, Geisbert TW, Kulakoski P, Wilson RB, Henderson L, Sabeti PC, Grant DS, Garry RF, Saphire EO, Branco LM, Khan SH, Viral Hemorrhagic Fever Consortium. PMID: 25531344; PMCID: PMC4287116.
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    129. Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17182-7. Murin CD, Fusco ML, Bornholdt ZA, Qiu X, Olinger GG, Zeitlin L, Kobinger GP, Ward AB, Saphire EO. PMID: 25404321; PMCID: PMC4260551.
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    130. Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names. Viruses. 2014 Sep 26; 6(9):3663-82. Kuhn JH, Andersen KG, Bào Y, Bavari S, Becker S, Bennett RS, Bergman NH, Blinkova O, Bradfute S, Brister JR, Bukreyev A, Chandran K, Chepurnov AA, Davey RA, Dietzgen RG, Doggett NA, Dolnik O, Dye JM, Enterlein S, Fenimore PW, Formenty P, Freiberg AN, Garry RF, Garza NL, Gire SK, Gonzalez JP, Griffiths A, Happi CT, Hensley LE, Herbert AS, Hevey MC, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson JC, Johnson KM, Kindrachuk J, Klenk HD, Kobinger G, Kochel TJ, Lackemeyer MG, Lackner DF, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Omilabu SA, Palacios G, Panchal RG, Park DJ, Patterson JL, Paweska JT, Peters CJ, Pettitt J, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Sabeti PC, Sealfon R, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. PMID: 25256396; PMCID: PMC4189044.
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    131. Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallogr D Biol Crystallogr. 2014 Jun; 70(Pt 6):1764-9. West BR, Hastie KM, Saphire EO. PMID: 24914986; PMCID: PMC4051510.
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    132. Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013. Arch Virol. 2014 Apr; 159(4):821-30. Bukreyev AA, Chandran K, Dolnik O, Dye JM, Ebihara H, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Saphire EO, Smither SJ, Takada A, Towner JS, Volchkov VE, Warren TK, Kuhn JH. PMID: 24122154; PMCID: PMC3984924.
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    133. Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein. Nucleic Acids Res. 2014 May; 42(9):6025-37. Olal D, Dick A, Woods VL, Liu T, Li S, Devignot S, Weber F, Saphire EO, Daumke O. PMID: 24688060; PMCID: PMC4027202.
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    134. Structure of the Reston ebolavirus VP30 C-terminal domain. Acta Crystallogr F Struct Biol Commun. 2014 Apr; 70(Pt 4):457-60. Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO. PMID: 24699737; PMCID: PMC3976061.
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    135. Lassa fever in post-conflict sierra leone. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2748. Shaffer JG, Grant DS, Schieffelin JS, Boisen ML, Goba A, Hartnett JN, Levy DC, Yenni RE, Moses LM, Fullah M, Momoh M, Fonnie M, Fonnie R, Kanneh L, Koroma VJ, Kargbo K, Ottomassathien D, Muncy IJ, Jones AB, Illick MM, Kulakosky PC, Haislip AM, Bishop CM, Elliot DH, Brown BL, Zhu H, Hastie KM, Andersen KG, Gire SK, Tabrizi S, Tariyal R, Stremlau M, Matschiner A, Sampey DB, Spence JS, Cross RW, Geisbert JB, Folarin OA, Happi CT, Pitts KR, Geske FJ, Geisbert TW, Saphire EO, Robinson JE, Wilson RB, Sabeti PC, Henderson LA, Khan SH, Bausch DG, Branco LM, Garry RF, Viral Hemorrhagic Fever Consortium. PMID: 24651047; PMCID: PMC3961205.
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    136. Complement is activated by IgG hexamers assembled at the cell surface. Science. 2014 Mar 14; 343(6176):1260-3. Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW. PMID: 24626930; PMCID: PMC4250092.
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    137. Crystal structure of Marburg virus VP24. J Virol. 2014 May; 88(10):5859-63. Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO. PMID: 24574400; PMCID: PMC4019143.
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    138. Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Arch Virol. 2014 May; 159(5):1229-37. Kuhn JH, Bào Y, Bavari S, Becker S, Bradfute S, Brauburger K, Rodney Brister J, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. PMID: 24190508; PMCID: PMC4010566.
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    139. An update on the use of antibodies against the filoviruses. Immunotherapy. 2013 Nov; 5(11):1221-33. Saphire EO. PMID: 24188676; PMCID: PMC4465755.
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    140. Crystal structure of the nipah virus phosphoprotein tetramerization domain. J Virol. 2014 Jan; 88(1):758-62. Bruhn JF, Barnett KC, Bibby J, Thomas JM, Keegan RM, Rigden DJ, Bornholdt ZA, Saphire EO. PMID: 24155387; PMCID: PMC3911761.
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    141. Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle. Cell. 2013 Aug 15; 154(4):763-74. Bornholdt ZA, Noda T, Abelson DM, Halfmann P, Wood MR, Kawaoka Y, Saphire EO. PMID: 23953110; PMCID: PMC4138722.
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    142. Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. J Virol. 2013 Sep; 87(18):10385-8. Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO. PMID: 23824825; PMCID: PMC3753998.
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    143. Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jun; 158(6):1425-32. Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Lofts LL, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. PMID: 23358612; PMCID: PMC3669655.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    144. Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein. Chembiochem. 2012 Nov 26; 13(17):2549-57. Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR. PMID: 23111988; PMCID: PMC3684266.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    145. Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jan; 158(1):301-11. Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Hensley LE, Honko AN, Jahrling PB, Johnson KM, Kobinger G, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Saphire EO, Smither SJ, Swanepoel R, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Weidmann M, Nichol ST. PMID: 23001720; PMCID: PMC3535543.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    146. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. PLoS Pathog. 2012 Sep; 8(9):e1002916. Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO. PMID: 23028316; PMCID: PMC3441732.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    147. Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease. PLoS One. 2012; 7(8):e44211. Hastie KM, King LB, Zandonatti MA, Saphire EO. PMID: 22937163; PMCID: PMC3429428.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    148. The ebolavirus VP24 interferon antagonist: know your enemy. Virulence. 2012 Aug 15; 3(5):440-5. Zhang AP, Abelson DM, Bornholdt ZA, Liu T, Woods VL, Saphire EO. PMID: 23076242; PMCID: PMC3485981.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    149. Structural basis for differential neutralization of ebolaviruses. Viruses. 2012 04; 4(4):447-70. Bale S, Dias JM, Fusco ML, Hashiguchi T, Wong AC, Liu T, Keuhne AI, Li S, Woods VL, Chandran K, Dye JM, Saphire EO. PMID: 22590681; PMCID: PMC3347318.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    150. The variety of study in the field of emerging viruses. Curr Opin Virol. 2012 Apr; 2(2):157-9. Saphire EO, Feldmann H. PMID: 22482713.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    151. The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog. 2012 Feb; 8(2):e1002550. Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL, Saphire EO. PMID: 22383882; PMCID: PMC3285596.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    152. Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses. Curr Opin Virol. 2012 Apr; 2(2):151-6. Hastie KM, Bale S, Kimberlin CR, Saphire EO. PMID: 22482712; PMCID: PMC3758253.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    153. Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus. J Virol. 2012 Mar; 86(5):2809-16. Olal D, Kuehne AI, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM, Saphire EO. PMID: 22171276; PMCID: PMC3302272.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    154. A shared structural solution for neutralizing ebolaviruses. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1424-7. Dias JM, Kuehne AI, Abelson DM, Bale S, Wong AC, Halfmann P, Muhammad MA, Fusco ML, Zak SE, Kang E, Kawaoka Y, Chandran K, Dye JM, Saphire EO. PMID: 22101933; PMCID: PMC3230659.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    155. Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion. PLoS Negl Trop Dis. 2011 Nov; 5(11):e1395. Bale S, Liu T, Li S, Wang Y, Abelson D, Fusco M, Woods VL, Saphire EO. PMID: 22102923; PMCID: PMC3216919.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    156. Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19365-70. Hastie KM, Liu T, Li S, King LB, Ngo N, Zandonatti MA, Woods VL, de la Torre JC, Saphire EO. PMID: 22084115; PMCID: PMC3228486.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    157. Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change. J Virol. 2012 Jan; 86(1):364-72. Brecher M, Schornberg KL, Delos SE, Fusco ML, Saphire EO, White JM. PMID: 22031933; PMCID: PMC3255896.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    158. Measles virus fusion shifts into gear. Nat Struct Mol Biol. 2011 Feb; 18(2):115-6. Saphire EO, Oldstone MB. PMID: 21289649.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    159. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2396-401. Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO. PMID: 21262835; PMCID: PMC3038715.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    160. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):314-9. Kimberlin CR, Bornholdt ZA, Li S, Woods VL, MacRae IJ, Saphire EO. PMID: 20018665; PMCID: PMC2806767.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    161. Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein. Acta Crystallogr D Biol Crystallogr. 2009 Nov; 65(Pt 11):1162-80. Lee JE, Fusco ML, Abelson DM, Hessell AJ, Burton DR, Saphire EO. PMID: 19923712; PMCID: PMC2777170.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    162. Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it. Curr Opin Struct Biol. 2009 Aug; 19(4):408-17. Lee JE, Saphire EO. PMID: 19559599; PMCID: PMC2759674.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    163. An efficient platform for screening expression and crystallization of glycoproteins produced in human cells. Nat Protoc. 2009; 4(4):592-604. Lee JE, Fusco ML, Saphire EO. PMID: 19373230; PMCID: PMC2911120.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    164. Ebolavirus glycoprotein structure and mechanism of entry. Future Virol. 2009; 4(6):621-635. Lee JE, Saphire EO. PMID: 20198110; PMCID: PMC2829775.
      View in: PubMed   Mentions: 135  
    165. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008 Jul 10; 454(7201):177-82. Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO. PMID: 18615077; PMCID: PMC2700032.
      View in: PubMed   Mentions: 412     Fields:    Translation:HumansAnimalsCells
    166. Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain. J Mol Biol. 2008 Jan 04; 375(1):202-16. Lee JE, Kuehne A, Abelson DM, Fusco ML, Hart MK, Saphire EO. PMID: 18005986; PMCID: PMC2173910.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    167. Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. J Mol Biol. 2007 Jun 08; 369(3):696-709. Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. PMID: 17445828; PMCID: PMC1995417.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    168. Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling. J Virol. 2006 Jun; 80(11):5168-78. Cárdenas WB, Loo YM, Gale M, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF. PMID: 16698997; PMCID: PMC1472134.
      View in: PubMed   Mentions: 253     Fields:    Translation:HumansAnimalsCells
    169. gp41: HIV's shy protein. Nat Med. 2004 Feb; 10(2):133-4. Zwick MB, Saphire EO, Burton DR. PMID: 14760422; PMCID: PMC7095992.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    170. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. J Virol. 2003 May; 77(10):5863-76. Zwick MB, Parren PW, Saphire EO, Church S, Wang M, Scott JK, Dawson PE, Wilson IA, Burton DR. PMID: 12719580; PMCID: PMC154005.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    171. Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. Adv Exp Med Biol. 2003; 535:55-66. Saphire EO, Stanfield RL, Crispin MD, Morris G, Zwick MB, Pantophlet RA, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. PMID: 14714888.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    172. The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12. Adv Exp Med Biol. 2003; 535:205-18. Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM. PMID: 14714897.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    173. Structure-based drug design. IDrugs. 2002 Jul; 5(7):658-61. Saphire EO. PMID: 14686344.
      View in: PubMed   Mentions:    Fields:    
    174. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J Virol. 2001 Nov; 75(22):10892-905. Zwick MB, Labrijn AF, Wang M, Spenlehauer C, Saphire EO, Binley JM, Moore JP, Stiegler G, Katinger H, Burton DR, Parren PW. PMID: 11602729; PMCID: PMC114669.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansCells
    175. Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. Acta Crystallogr D Biol Crystallogr. 2001 Jan; 57(Pt 1):168-71. Saphire EO, Parren PW, Barbas CF, Burton DR, Wilson IA. PMID: 11134947.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    176. gp120: Biologic aspects of structural features. Annu Rev Immunol. 2001; 19:253-74. Poignard P, Saphire EO, Parren PW, Burton DR. PMID: 11244037.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    177. A model for neutralization of viruses based on antibody coating of the virion surface. Curr Top Microbiol Immunol. 2001; 260:109-43. Burton DR, Saphire EO, Parren PW. PMID: 11443871.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
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