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Nicole Steinmetz

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address9500 Gilman Drive #0448
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Protein/Polymer Devices for Slow-Release of Immunotherapies to Treat Ovarian Cancer
    NIH/NIBIB R21EB024874Sep 5, 2017 - Jun 30, 2019
    Role: Co-Principal Investigator
    Overcoming the immune-suppressive tumor microenvironment through in situ vaccination nanotechnology
    NIH/NCI U01CA218292Sep 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Dual-pronged nano-drug delivery using plant virus-like particles
    NIH/NCI R01CA224605Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    A theranostic approach for risk stratification and intervention of deep vein thrombosis
    NIH/NHLBI R01HL137674Jul 1, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Diagnosis and longitudinal monitoring of metastatic prostate cancer through molecular MR imaging
    NIH/NCI R01CA202814Feb 1, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Engineering 'Grapevine Virus A' filaments for nanomedical applications
    NIH/NIBIB R03EB020602Sep 14, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Detection of lethal prostate cancer with macromolecule-based, EGFL-7 targeted MR imaging approach
    NIH/NIBIB R21EB020946Jul 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Drug Delivery to Thrombotic Cardiovascular Disease
    NIH/NHLBI R21HL121130Nov 14, 2014 - Oct 31, 2016
    Role: Principal Investigator
    Viral nanoparticles as platforms for the design of novel targeted therapeutics
    NIH/NIBIB R00EB009105Aug 1, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Viral nanoparticles as platforms for the design of novel targeted therapeutics
    NIH/NIBIB K99EB009105Aug 1, 2009 - Jul 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lu ZR, Steinmetz NF, Zhu H. New Directions for Drug Delivery in Cancer Therapy. Mol Pharm. 2018 Sep 04; 15(9):3601-3602. PMID: 30176732.
      View in: PubMed
    2. Lin RD, Steinmetz NF. Tobacco mosaic virus delivery of mitoxantrone for cancer therapy. Nanoscale. 2018 Aug 30; 10(34):16307-16313. PMID: 30129956.
      View in: PubMed
    3. Pitek AS, Park J, Wang Y, Gao H, Hu H, Simon DI, Steinmetz NF. Delivery of thrombolytic therapy using rod-shaped plant viral nanoparticles decreases the risk of hemorrhage. Nanoscale. 2018 Aug 23. PMID: 30137088.
      View in: PubMed
    4. Murray AA, Wang C, Fiering S, Steinmetz NF. In Situ Vaccination with Cowpea vs Tobacco Mosaic Virus against Melanoma. Mol Pharm. 2018 May 25. PMID: 29798673.
      View in: PubMed
    5. Gulati NM, Stewart PL, Steinmetz NF. Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications. Mol Pharm. 2018 May 15. PMID: 29733602.
      View in: PubMed
    6. Hoopes PJ, Wagner RJ, Duval K, Kang K, Gladstone DJ, Moodie KL, Crary-Burney M, Ariaspulido H, Veliz FA, Steinmetz NF, Fiering SN. Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation. Mol Pharm. 2018 Apr 12. PMID: 29613803.
      View in: PubMed
    7. Patel R, Czapar AE, Fiering S, Oleinick NL, Steinmetz NF. Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression. ACS Omega. 2018 Apr 30; 3(4):3702-3707. PMID: 29732445.
      View in: PubMed
    8. Vernekar AA, Berger G, Czapar AE, Veliz FA, Wang DI, Steinmetz NF, Lippard SJ. Speciation of Phenanthriplatin and Its Analogs in the Core of Tobacco Mosaic Virus. J Am Chem Soc. 2018 03 28; 140(12):4279-4287. PMID: 29553267.
      View in: PubMed
    9. Czapar AE, Tiu BDB, Veliz FA, Pokorski JK, Steinmetz NF. Slow-Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer. Adv Sci (Weinh). 2018 May; 5(5):1700991. PMID: 29876220.
      View in: PubMed
    10. Pitek AS, Veliz FA, Jameson SA, Steinmetz NF. Interactions Between Plant Viral Nanoparticles (VNPs) and Blood Plasma Proteins, and Their Impact on the VNP In Vivo Fates. Methods Mol Biol. 2018; 1776:591-608. PMID: 29869268.
      View in: PubMed
    11. Bruckman MA, Czapar AE, Steinmetz NF. Drug-Loaded Plant-Virus Based Nanoparticles for Cancer Drug Delivery. Methods Mol Biol. 2018; 1776:425-436. PMID: 29869258.
      View in: PubMed
    12. Shukla S, Dickmeis C, Fischer R, Commandeur U, Steinmetz NF. In Planta Production of Fluorescent Filamentous Plant Virus-Based Nanoparticles. Methods Mol Biol. 2018; 1776:61-84. PMID: 29869235.
      View in: PubMed
    13. Tiu BDB, Advincula RC, Steinmetz NF. Nanomanufacture of Free-Standing, Porous, Janus-Type Films of Polymer-Plant Virus Nanoparticle Arrays. Methods Mol Biol. 2018; 1776:143-157. PMID: 29869239.
      View in: PubMed
    14. Masarapu H, Patel BK, Chariou PL, Hu H, Gulati NM, Carpenter BL, Ghiladi RA, Shukla S, Steinmetz NF. Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs. Biomacromolecules. 2017 Dec 11; 18(12):4141-4153. PMID: 29144726.
      View in: PubMed
    15. Pitek AS, Wang Y, Gulati S, Gao H, Stewart PL, Simon DI, Steinmetz NF. Elongated Plant Virus-Based Nanoparticles for Enhanced Delivery of Thrombolytic Therapies. Mol Pharm. 2017 Nov 06; 14(11):3815-3823. PMID: 28881141.
      View in: PubMed
    16. Franke CE, Czapar AE, Patel RB, Steinmetz NF. Tobacco Mosaic Virus-Delivered Cisplatin Restores Efficacy in Platinum-Resistant Ovarian Cancer Cells. Mol Pharm. 2017 Sep 19. PMID: 28926265.
      View in: PubMed
    17. Lee PW, Shukla S, Wallat JD, Danda C, Steinmetz NF, Maia J, Pokorski JK. Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing. ACS Nano. 2017 Sep 26; 11(9):8777-8789. PMID: 28902491.
      View in: PubMed
    18. Hu H, Zhang Y, Shukla S, Gu Y, Yu X, Steinmetz NF. Dysprosium-Modified Tobacco Mosaic Virus Nanoparticles for Ultra-High-Field Magnetic Resonance and Near-Infrared Fluorescence Imaging of Prostate Cancer. ACS Nano. 2017 Sep 26; 11(9):9249-9258. PMID: 28858475.
      View in: PubMed
    19. Steinmetz N. Enter the Nanoman. Nat Nanotechnol. 2017 Sep 06; 12(9):928. PMID: 28875983.
      View in: PubMed
    20. Cho CF, Yu L, Nsiama TK, Kadam AN, Raturi A, Shukla S, Amadei GA, Steinmetz NF, Luyt LG, Lewis JD. Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature. Nanoscale. 2017 Aug 24; 9(33):12096-12109. PMID: 28799610.
      View in: PubMed
    21. Anderson CE, Donnola SB, Jiang Y, Batesole J, Darrah R, Drumm ML, Brady-Kalnay SM, Steinmetz NF, Yu X, Griswold MA, Flask CA. Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents. Sci Rep. 2017 Aug 16; 7(1):8431. PMID: 28814732.
      View in: PubMed
    22. Lam P, Steinmetz NF. Plant viral and bacteriophage delivery of nucleic acid therapeutics. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 01; 10(1). PMID: 28719102.
      View in: PubMed
    23. Kernan DL, Wen AM, Pitek AS, Steinmetz NF. Featured Article: Delivery of chemotherapeutic vcMMAE using tobacco mosaic virus nanoparticles. Exp Biol Med (Maywood). 2017 08; 242(14):1405-1411. PMID: 28675044.
      View in: PubMed
    24. Lee KL, Murray AA, Le DHT, Sheen MR, Shukla S, Commandeur U, Fiering S, Steinmetz NF. Combination of Plant Virus Nanoparticle-Based in Situ Vaccination with Chemotherapy Potentiates Antitumor Response. Nano Lett. 2017 Jul 12; 17(7):4019-4028. PMID: 28650644.
      View in: PubMed
    25. Poudel L, Twarock R, Steinmetz NF, Podgornik R, Ching WY. Impact of Hydrogen Bonding in the Binding Site between Capsid Protein and MS2 Bacteriophage ssRNA. J Phys Chem B. 2017 07 06; 121(26):6321-6330. PMID: 28581757.
      View in: PubMed
    26. Le DHT, Hu H, Commandeur U, Steinmetz NF. Chemical addressability of potato virus X for its applications in bio/nanotechnology. J Struct Biol. 2017 Dec; 200(3):360-368. PMID: 28647539.
      View in: PubMed
    27. Czapar AE, Steinmetz NF. Plant viruses and bacteriophages for drug delivery in medicine and biotechnology. Curr Opin Chem Biol. 2017 Jun; 38:108-116. PMID: 28426952.
      View in: PubMed
    28. Chariou PL, Steinmetz NF. Delivery of Pesticides to Plant Parasitic Nematodes Using Tobacco Mild Green Mosaic Virus as a Nanocarrier. ACS Nano. 2017 May 23; 11(5):4719-4730. PMID: 28345874.
      View in: PubMed
    29. Gulati NM, Pitek AS, Steinmetz NF, Stewart PL. Cryo-electron tomography investigation of serum albumin-camouflaged tobacco mosaic virus nanoparticles. Nanoscale. 2017 Mar 09; 9(10):3408-3415. PMID: 28112764.
      View in: PubMed
    30. Hoopes PJ, Moodie KL, Petryk AA, Petryk JD, Sechrist S, Gladstone DJ, Steinmetz NF, Veliz FA, Bursey AA, Wagner RJ, Rajan A, Dugat D, Crary-Burney M, Fiering SN. Hypo-fractionated Radiation, Magnetic Nanoparticle Hyperthermia and a Viral Immunotherapy Treatment of Spontaneous Canine Cancer. Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb; 10066. PMID: 29203951.
      View in: PubMed
    31. Hoopes PJ, Mazur CM, Osterberg B, Song A, Gladstone DJ, Steinmetz NF, Veliz FA, Bursey AA, Wagner RJ, Fiering SN. Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer. Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb; 10066. PMID: 29203952.
      View in: PubMed
    32. Le DH, Lee KL, Shukla S, Commandeur U, Steinmetz NF. Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy. Nanoscale. 2017 Feb 09; 9(6):2348-2357. PMID: 28144662.
      View in: PubMed
    33. Tiu BD, Kernan DL, Tiu SB, Wen AM, Zheng Y, Pokorski JK, Advincula RC, Steinmetz NF. Electrostatic layer-by-layer construction of fibrous TMV biofilms. Nanoscale. 2017 Jan 26; 9(4):1580-1590. PMID: 28070572.
      View in: PubMed
    34. Lee PW, Isarov SA, Wallat JD, Molugu SK, Shukla S, Sun JE, Zhang J, Zheng Y, Lucius Dougherty M, Konkolewicz D, Stewart PL, Steinmetz NF, Hore MJ, Pokorski JK. Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle-Polymer Conjugates. J Am Chem Soc. 2017 03 08; 139(9):3312-3315. PMID: 28121424.
      View in: PubMed
    35. Shukla S, Myers JT, Woods SE, Gong X, Czapar AE, Commandeur U, Huang AY, Levine AD, Steinmetz NF. Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers. Biomaterials. 2017 03; 121:15-27. PMID: 28063980.
      View in: PubMed
    36. Wallat JD, Czapar AE, Wang C, Wen AM, Wek KS, Yu X, Steinmetz NF, Pokorski JK. Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles. Biomacromolecules. 2017 01 09; 18(1):103-112. PMID: 27992176.
      View in: PubMed
    37. Bludau H, Czapar AE, Pitek AS, Shukla S, Jordan R, Steinmetz NF. POxylation as an alternative stealth coating for biomedical applications. Eur Polym J. 2017 Mar; 88:679-688. PMID: 28713172.
      View in: PubMed
    38. Poudel L, Steinmetz NF, French RH, Parsegian VA, Podgornik R, Ching WY. Implication of the solvent effect, metal ions and topology in the electronic structure and hydrogen bonding of human telomeric G-quadruplex DNA. Phys Chem Chem Phys. 2016 Aug 03; 18(31):21573-85. PMID: 27425864.
      View in: PubMed
    39. Sreekanth KV, Alapan Y, ElKabbash M, Wen AM, Ilker E, Hinczewski M, Gurkan UA, Steinmetz NF, Strangi G. Enhancing the Angular Sensitivity of Plasmonic Sensors Using Hyperbolic Metamaterials. Adv Opt Mater. 2016 Nov; 4(11):1767-1772. PMID: 28649484.
      View in: PubMed
    40. Wen AM, Steinmetz NF. Design of virus-based nanomaterials for medicine, biotechnology, and energy. Chem Soc Rev. 2016 07 25; 45(15):4074-126. PMID: 27152673.
      View in: PubMed
    41. Tiu BD, Tiu SB, Wen AM, Lam P, Steinmetz NF, Advincula RC. Free-Standing, Nanopatterned Janus Membranes of Conducting Polymer-Virus Nanoparticle Arrays. Langmuir. 2016 Jun 21; 32(24):6185-93. PMID: 27244119.
      View in: PubMed
    42. Yasar S, Schimelman JB, Aksoyoglu MA, Steinmetz NF, French RH, Parsegian VA, Podgornik R. X-ray characterization of mesophases of human telomeric G-quadruplexes and other DNA analogues. Sci Rep. 2016 06 02; 6:27079. PMID: 27249961.
      View in: PubMed
    43. Shukla S, Steinmetz NF. Emerging nanotechnologies for cancer immunotherapy. Exp Biol Med (Maywood). 2016 05; 241(10):1116-26. PMID: 27190253.
      View in: PubMed
    44. Wen AM, Lee KL, Cao P, Pangilinan K, Carpenter BL, Lam P, Veliz FA, Ghiladi RA, Advincula RC, Steinmetz NF. Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells. Bioconjug Chem. 2016 05 18; 27(5):1227-35. PMID: 27077475.
      View in: PubMed
    45. Chariou PL, Lee KL, Pokorski JK, Saidel GM, Steinmetz NF. Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio. J Phys Chem B. 2016 07 07; 120(26):6120-9. PMID: 27045770.
      View in: PubMed
    46. Lam P, Gulati NM, Stewart PL, Keri RA, Steinmetz NF. Bioengineering of Tobacco Mosaic Virus to Create a Non-Infectious Positive Control for Ebola Diagnostic Assays. Sci Rep. 2016 Mar 31; 6:23803. PMID: 27030058; PMCID: PMC4814824.
    47. Shukla S, Dorand RD, Myers JT, Woods SE, Gulati NM, Stewart PL, Commandeur U, Huang AY, Steinmetz NF. Multiple Administrations of Viral Nanoparticles Alter in Vivo Behavior-Insights from Intravital Microscopy. ACS Biomater Sci Eng. 2016 May 09; 2(5):829-837. PMID: 28752131.
      View in: PubMed
    48. Czapar AE, Zheng YR, Riddell IA, Shukla S, Awuah SG, Lippard SJ, Steinmetz NF. Tobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy. ACS Nano. 2016 04 26; 10(4):4119-26. PMID: 26982250.
      View in: PubMed
    49. Ganguly R, Wen AM, Myer AB, Czech T, Sahu S, Steinmetz NF, Raman P. Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro. Nanoscale. 2016 Mar 28; 8(12):6542-54. PMID: 26935414.
      View in: PubMed
    50. Lee KL, Carpenter BL, Wen AM, Ghiladi RA, Steinmetz NF. High Aspect Ratio Nanotubes Formed by Tobacco Mosaic Virus for Delivery of Photodynamic Agents Targeting Melanoma. ACS Biomater Sci Eng. 2016 May 09; 2(5):838-844. PMID: 28713855.
      View in: PubMed
    51. Bruckman MA, Czapar AE, VanMeter A, Randolph LN, Steinmetz NF. Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer. J Control Release. 2016 06 10; 231:103-13. PMID: 26941034.
      View in: PubMed
    52. Pitek AS, Jameson SA, Veliz FA, Shukla S, Steinmetz NF. Serum albumin 'camouflage' of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics. Biomaterials. 2016 May; 89:89-97. PMID: 26950168.
      View in: PubMed
    53. Pitek AS, Wen AM, Shukla S, Steinmetz NF. The Protein Corona of Plant Virus Nanoparticles Influences their Dispersion Properties, Cellular Interactions, and In Vivo Fates. Small. 2016 Apr 06; 12(13):1758-69. PMID: 26853911.
      View in: PubMed
    54. Lee KL, Twyman RM, Fiering S, Steinmetz NF. Virus-based nanoparticles as platform technologies for modern vaccines. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 07; 8(4):554-78. PMID: 26782096.
      View in: PubMed
    55. Wen AM, Le N, Zhou X, Steinmetz NF, Popkin DL. Tropism of CPMV to Professional Antigen Presenting Cells Enables a Platform to Eliminate Chronic Infections. ACS Biomater Sci Eng. 2015 Nov 09; 1(11):1050-1054. PMID: 27280157.
      View in: PubMed
    56. Uhde-Holzem K, McBurney M, Tiu BD, Advincula RC, Fischer R, Commandeur U, Steinmetz NF. Production of Immunoabsorbent Nanoparticles by Displaying Single-Domain Protein A on Potato Virus X. Macromol Biosci. 2016 Feb; 16(2):231-41. PMID: 26440117.
      View in: PubMed
    57. Koudelka KJ, Pitek AS, Manchester M, Steinmetz NF. Virus-Based Nanoparticles as Versatile Nanomachines. Annu Rev Virol. 2015 Nov; 2(1):379-401. PMID: 26958921.
      View in: PubMed
    58. Au L, Meisch JP, Das LM, Binko AM, Boxer RS, Wen AM, Steinmetz NF, Lu KQ. Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol. 2015 Dec; 135(12):2971-2981. PMID: 26288355; PMCID: PMC4648631.
    59. Worden M, Bruckman MA, Kim MH, Steinmetz NF, Kikkawa JM, LaSpina C, Hegmann T. Aqueous synthesis of polyhedral "brick-like" iron oxide nanoparticles for hyperthermia and T2 MRI contrast enhancement. J Mater Chem B. 2015 Sep 15; 3(34):6877-6884. PMID: 26693011.
      View in: PubMed
    60. Bruckman MA, Randolph LN, Gulati NM, Stewart PL, Steinmetz NF. Silica-coated Gd(DOTA)-loaded protein nanoparticles enable magnetic resonance imaging of macrophages. J Mater Chem B. 2015 Oct 01; 3(38):7503-7510. PMID: 26659591.
      View in: PubMed
    61. Wen AM, Wang Y, Jiang K, Hsu GC, Gao H, Lee KL, Yang AC, Yu X, Simon DI, Steinmetz NF. Shaping bio-inspired nanotechnologies to target thrombosis for dual optical-magnetic resonance imaging. J Mater Chem B. 2015 Aug 07; 3(29):6037-6045. PMID: 26509036.
      View in: PubMed
    62. Dryden DM, Hopkins JC, Denoyer LK, Poudel L, Steinmetz NF, Ching WY, Podgornik R, Parsegian A, French RH. van der Waals Interactions on the Mesoscale: Open-Science Implementation, Anisotropy, Retardation, and Solvent Effects. Langmuir. 2015 Sep 22; 31(37):10145-53. PMID: 25815562.
      View in: PubMed
    63. Shukla S, DiFranco NA, Wen AM, Commandeur U, Steinmetz NF. To Target or Not to Target: Active vs. Passive Tumor Homing of Filamentous Nanoparticles Based on Potato virus X. Cell Mol Bioeng. 2015; 8(3):433-444. PMID: 26316894.
      View in: PubMed
    64. Lee KL, Shukla S, Wu M, Ayat NR, El Sanadi CE, Wen AM, Edelbrock JF, Pokorski JK, Commandeur U, Dubyak GR, Steinmetz NF. Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X. Acta Biomater. 2015 Jun; 19:166-79. PMID: 25769228; PMCID: PMC4411193.
    65. Wen AM, Podgornik R, Strangi G, Steinmetz NF. Photonics and plasmonics go viral: self-assembly of hierarchical metamaterials. Rend Lincei Sci Fis Nat. 2015 Aug; 26(2 Suppl):129-141. PMID: 28713533.
      View in: PubMed
    66. Poudel L, Wen AM, French RH, Parsegian VA, Podgornik R, Steinmetz NF, Ching WY. Electronic structure and partial charge distribution of Doxorubicin in different molecular environments. Chemphyschem. 2015 May 18; 16(7):1451-60. PMID: 25728554.
      View in: PubMed
    67. Schimelman JB, Dryden DM, Poudel L, Krawiec KE, Ma Y, Podgornik R, Parsegian VA, Denoyer LK, Ching WY, Steinmetz NF, French RH. Optical properties and electronic transitions of DNA oligonucleotides as a function of composition and stacking sequence. Phys Chem Chem Phys. 2015 Feb 14; 17(6):4589-99. PMID: 25584920.
      View in: PubMed
    68. Shukla S, Steinmetz NF. Virus-based nanomaterials as positron emission tomography and magnetic resonance contrast agents: from technology development to translational medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Sep-Oct; 7(5):708-21. PMID: 25683790; PMCID: PMC4620044.
    69. Chariou PL, Lee KL, Wen AM, Gulati NM, Stewart PL, Steinmetz NF. Detection and imaging of aggressive cancer cells using an epidermal growth factor receptor (EGFR)-targeted filamentous plant virus-based nanoparticle. Bioconjug Chem. 2015 Feb 18; 26(2):262-269. PMID: 25611133; PMCID: PMC4859893.
    70. Shukla S, Eber FJ, Nagarajan AS, DiFranco NA, Schmidt N, Wen AM, Eiben S, Twyman RM, Wege C, Steinmetz NF. The Impact of Aspect Ratio on the Biodistribution and Tumor Homing of Rigid Soft-Matter Nanorods. Adv Healthc Mater. 2015 Apr 22; 4(6):874-82. PMID: 25641794; PMCID: PMC4934124.
    71. Wen AM, Infusino M, De Luca A, Kernan DL, Czapar AE, Strangi G, Steinmetz NF. Interface of physics and biology: engineering virus-based nanoparticles for biophotonics. Bioconjug Chem. 2015 Jan 21; 26(1):51-62. PMID: 25541212; PMCID: PMC4306514.
    72. Bruckman MA, VanMeter A, Steinmetz NF. Nanomanufacturing of Tobacco Mosaic Virus-Based Spherical Biomaterials Using a Continuous Flow Method. ACS Biomater Sci Eng. 2015 Jan 12; 1(1):13-18. PMID: 25984569.
      View in: PubMed
    73. Ma Y, Acosta DM, Whitney JR, Podgornik R, Steinmetz NF, French RH, Parsegian VA. Determination of the second virial coefficient of bovine serum albumin under varying pH and ionic strength by composition-gradient multi-angle static light scattering. J Biol Phys. 2015 Jan; 41(1):85-97. PMID: 25403822; PMCID: PMC4298003.
    74. Rehor I, Lee KL, Chen K, Hajek M, Havlik J, Lokajova J, Masat M, Slegerova J, Shukla S, Heidari H, Bals S, Steinmetz NF, Cigler P. Plasmonic nanodiamonds: targeted core-shell type nanoparticles for cancer cell thermoablation. Adv Healthc Mater. 2015 Feb 18; 4(3):460-8. PMID: 25336437; PMCID: PMC4411186.
    75. Adhikari P, Wen AM, French RH, Parsegian VA, Steinmetz NF, Podgornik R, Ching WY. Electronic structure, dielectric response, and surface charge distribution of RGD (1FUV) peptide. Sci Rep. 2014 Jul 08; 4:5605. PMID: 25001596; PMCID: PMC4085632.
    76. Wen AM, Steinmetz NF. The aspect ratio of nanoparticle assemblies and the spatial arrangement of ligands can be optimized to enhance the targeting of cancer cells. Adv Healthc Mater. 2014 Nov; 3(11):1739-44. PMID: 24729309; PMCID: PMC4859891.
    77. Bruckman MA, Jiang K, Simpson EJ, Randolph LN, Luyt LG, Yu X, Steinmetz NF. Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus. Nano Lett. 2014 Mar 12; 14(3):1551-8. PMID: 24499194; PMCID: PMC4169141.
    78. Rehor I, Slegerova J, Kucka J, Proks V, Petrakova V, Adam MP, Treussart F, Turner S, Bals S, Sacha P, Ledvina M, Wen AM, Steinmetz NF, Cigler P. Fluorescent nanodiamonds embedded in biocompatible translucent shells. Small. 2014 Mar 26; 10(6):1106-15. PMID: 24500945.
      View in: PubMed
    79. Bruckman MA, Steinmetz NF. Chemical modification of the inner and outer surfaces of Tobacco Mosaic Virus (TMV). Methods Mol Biol. 2014; 1108:173-85. PMID: 24243249; PMCID: PMC4546836.
    80. Lee KL, Uhde-Holzem K, Fischer R, Commandeur U, Steinmetz NF. Genetic engineering and chemical conjugation of potato virus X. Methods Mol Biol. 2014; 1108:3-21. PMID: 24243237.
      View in: PubMed
    81. Cho CF, Shukla S, Simpson EJ, Steinmetz NF, Luyt LG, Lewis JD. Molecular targeted viral nanoparticles as tools for imaging cancer. Methods Mol Biol. 2014; 1108:211-30. PMID: 24243252; PMCID: PMC4546835.
    82. Bruckman MA, Randolph LN, VanMeter A, Hern S, Shoffstall AJ, Taurog RE, Steinmetz NF. Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice. Virology. 2014 Jan 20; 449:163-73. PMID: 24418549; PMCID: PMC3906584.
    83. Bruckman MA, Yu X, Steinmetz NF. Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via T(1) shortening. Nanotechnology. 2013 Nov 22; 24(46):462001. PMID: 24158750; PMCID: PMC3895399.
    84. Shukla S, Wen AM, Ayat NR, Commandeur U, Gopalkrishnan R, Broome AM, Lozada KW, Keri RA, Steinmetz NF. Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine (Lond). 2014 Feb; 9(2):221-35. PMID: 23834501; PMCID: PMC4169171.
    85. Lee KL, Hubbard LC, Hern S, Yildiz I, Gratzl M, Steinmetz NF. Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct. Biomater Sci. 2013 Jun; 1(6). PMID: 24244867.
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    86. Yildiz I, Lee KL, Chen K, Shukla S, Steinmetz NF. Infusion of imaging and therapeutic molecules into the plant virus-based carrier cowpea mosaic virus: cargo-loading and delivery. J Control Release. 2013 Dec 10; 172(2):568-78. PMID: 23665254; PMCID: PMC3815978.
    87. Wen AM, Rambhia PH, French RH, Steinmetz NF. Design rules for nanomedical engineering: from physical virology to the applications of virus-based materials in medicine. J Biol Phys. 2013 Mar; 39(2):301-25. PMID: 23860875; PMCID: PMC3662409.
    88. Bruckman MA, Hern S, Jiang K, Flask CA, Yu X, Steinmetz NF. Tobacco mosaic virus rods and spheres as supramolecular high-relaxivity MRI contrast agents. J Mater Chem B. 2013 Mar 14; 1(10):1482-1490. PMID: 23589767.
      View in: PubMed
    89. Steinmetz NF. Viral nanoparticles in drug delivery and imaging. Mol Pharm. 2013 Jan 07; 10(1):1-2. PMID: 23294244.
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    90. Wen AM, Lee KL, Yildiz I, Bruckman MA, Shukla S, Steinmetz NF. Viral nanoparticles for in vivo tumor imaging. J Vis Exp. 2012 Nov 16; (69):e4352. PMID: 23183850; PMCID: PMC3572551.
    91. Wen AM, Shukla S, Saxena P, Aljabali AA, Yildiz I, Dey S, Mealy JE, Yang AC, Evans DJ, Lomonossoff GP, Steinmetz NF. Interior engineering of a viral nanoparticle and its tumor homing properties. Biomacromolecules. 2012 Dec 10; 13(12):3990-4001. PMID: 23121655; PMCID: PMC3525095.
    92. Aljabali AA, Barclay JE, Steinmetz NF, Lomonossoff GP, Evans DJ. Controlled immobilisation of active enzymes on the cowpea mosaic virus capsid. Nanoscale. 2012 Sep 21; 4(18):5640-5. PMID: 22865109.
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    93. Aljabali AA, Shukla S, Lomonossoff GP, Steinmetz NF, Evans DJ. CPMV-DOX delivers. Mol Pharm. 2013 Jan 07; 10(1):3-10. PMID: 22827473; PMCID: PMC3564650.
    94. Wen AM, Ryan MJ, Yang AC, Breitenkamp K, Pokorski JK, Steinmetz NF. Photodynamic activity of viral nanoparticles conjugated with C60. Chem Commun (Camb). 2012 Sep 18; 48(72):9044-6. PMID: 22858632; PMCID: PMC3470913.
    95. Shukla S, Ablack AL, Wen AM, Lee KL, Lewis JD, Steinmetz NF. Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle Potato virus X. Mol Pharm. 2013 Jan 07; 10(1):33-42. PMID: 22731633; PMCID: PMC3482416.
    96. Hovlid ML, Steinmetz NF, Laufer B, Lau JL, Kuzelka J, Wang Q, Hyypiä T, Nemerow GR, Kessler H, Manchester M, Finn MG. Guiding plant virus particles to integrin-displaying cells. Nanoscale. 2012 Jun 21; 4(12):3698-705. PMID: 22585108; PMCID: PMC3567620.
    97. Wu Z, Chen K, Yildiz I, Dirksen A, Fischer R, Dawson PE, Steinmetz NF. Development of viral nanoparticles for efficient intracellular delivery. Nanoscale. 2012 Jun 07; 4(11):3567-76. PMID: 22508503; PMCID: PMC3563001.
    98. Yildiz I, Tsvetkova I, Wen AM, Shukla S, Masarapu MH, Dragnea B, Steinmetz NF. Engineering of Brome mosaic virus for biomedical applications. RSC Adv. 2012 May 07; 2(9):3670-3677. PMID: 28018580.
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    99. Taghavian O, Mandal MK, Steinmetz NF, Rasche S, Spiegel H, Fischer R, Schillberg S. A potential nanobiotechnology platform based on infectious bursal disease subviral particles. RSC Adv. 2012 Mar 07; 2(5):1970-1978. PMID: 28638593.
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    100. Steinmetz NF, Maurer J, Sheng H, Bensussan A, Maricic I, Kumar V, Braciak TA. Two Domains of Vimentin Are Expressed on the Surface of Lymph Node, Bone and Brain Metastatic Prostate Cancer Lines along with the Putative Stem Cell Marker Proteins CD44 and CD133. Cancers (Basel). 2011 Jul 13; 3(3):2870-85. PMID: 24212937; PMCID: PMC3759176.
    101. Yildiz I, Shukla S, Steinmetz NF. Applications of viral nanoparticles in medicine. Curr Opin Biotechnol. 2011 Dec; 22(6):901-8. PMID: 21592772; PMCID: PMC3206135.
    102. Steinmetz NF, Ablack AL, Hickey JL, Ablack J, Manocha B, Mymryk JS, Luyt LG, Lewis JD. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small. 2011 Jun 20; 7(12):1664-72. PMID: 21520408; PMCID: PMC3163449.
    103. Steinmetz NF, Cho CF, Ablack A, Lewis JD, Manchester M. Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells. Nanomedicine (Lond). 2011 Feb; 6(2):351-64. PMID: 21385137; PMCID: PMC3436905.
    104. Huang RK, Steinmetz NF, Fu CY, Manchester M, Johnson JE. Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells. Nanomedicine (Lond). 2011 Jan; 6(1):55-68. PMID: 21182418; PMCID: PMC3091364.
    105. Pokorski JK, Steinmetz NF. The art of engineering viral nanoparticles. Mol Pharm. 2011 Feb 07; 8(1):29-43. PMID: 21047140; PMCID: PMC3156490.
    106. Hong V, Steinmetz NF, Manchester M, Finn MG. Labeling live cells by copper-catalyzed alkyne--azide click chemistry. Bioconjug Chem. 2010 Oct 20; 21(10):1912-6. PMID: 20886827; PMCID: PMC3014321.
    107. Leong HS, Steinmetz NF, Ablack A, Destito G, Zijlstra A, Stuhlmann H, Manchester M, Lewis JD. Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles. Nat Protoc. 2010 Aug; 5(8):1406-17. PMID: 20671724; PMCID: PMC3163450.
    108. Steinmetz NF. Viral nanoparticles as platforms for next-generation therapeutics and imaging devices. Nanomedicine. 2010 Oct; 6(5):634-41. PMID: 20433947; PMCID: PMC2948632.
    109. Brunel FM, Lewis JD, Destito G, Steinmetz NF, Manchester M, Stuhlmann H, Dawson PE. Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Lett. 2010 Mar 10; 10(3):1093-7. PMID: 20163184; PMCID: PMC3988696.
    110. Steinmetz NF, Mertens ME, Taurog RE, Johnson JE, Commandeur U, Fischer R, Manchester M. Potato virus X as a novel platform for potential biomedical applications. Nano Lett. 2010 Jan; 10(1):305-12. PMID: 20017489; PMCID: PMC2958517.
    111. Steinmetz NF, Hong V, Spoerke ED, Lu P, Breitenkamp K, Finn MG, Manchester M. Buckyballs meet viral nanoparticles: candidates for biomedicine. J Am Chem Soc. 2009 Dec 02; 131(47):17093-5. PMID: 19904938; PMCID: PMC2797550.
    112. Shah SN, Steinmetz NF, Aljabali AA, Lomonossoff GP, Evans DJ. Environmentally benign synthesis of virus-templated, monodisperse, iron-platinum nanoparticles. Dalton Trans. 2009 Oct 28; (40):8479-80. PMID: 19809720.
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    113. Tellechea E, Johannsmann D, Steinmetz NF, Richter RP, Reviakine I. Model-independent analysis of QCM data on colloidal particle adsorption. Langmuir. 2009 May 05; 25(9):5177-84. PMID: 19397357.
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    114. Steinmetz NF, Manchester M. PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo. Biomacromolecules. 2009 Apr 13; 10(4):784-92. PMID: 19281149; PMCID: PMC2849976.
    115. Steinmetz NF, Shah SN, Barclay JE, Rallapalli G, Lomonossoff GP, Evans DJ. Virus-templated silica nanoparticles. Small. 2009 Apr; 5(7):813-6. PMID: 19197969.
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    116. Manchester M, Steinmetz NF. Viruses and nanotechnology. Preface. Curr Top Microbiol Immunol. 2009; 327:v-vi. PMID: 19198567.
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    117. Bingen P, Wang G, Steinmetz NF, Rodahl M, Richter RP. Solvation effects in the quartz crystal microbalance with dissipation monitoring response to biomolecular adsorption. A phenomenological approach. Anal Chem. 2008 Dec 01; 80(23):8880-90. PMID: 19551969.
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    118. Steinmetz NF, Findlay KC, Noel TR, Parker R, Lomonossoff GP, Evans DJ. Layer-by-layer assembly of viral nanoparticles and polyelectrolytes: the film architecture is different for spheres versus rods. Chembiochem. 2008 Jul 02; 9(10):1662-70. PMID: 18536062.
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    119. Steinmetz NF, Bock E, Richter RP, Spatz JP, Lomonossoff GP, Evans DJ. Assembly of multilayer arrays of viral nanoparticles via biospecific recognition: a quartz crystal microbalance with dissipation monitoring study. Biomacromolecules. 2008 Feb; 9(2):456-62. PMID: 18197628.
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    120. Steinmetz NF, Evans DJ. Utilisation of plant viruses in bionanotechnology. Org Biomol Chem. 2007 Sep 21; 5(18):2891-902. PMID: 17728853.
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    121. Steinmetz NF, Evans DJ, Lomonossoff GP. Chemical introduction of reactive thiols into a viral nanoscaffold: a method that avoids virus aggregation. Chembiochem. 2007 Jul 09; 8(10):1131-6. PMID: 17526061.
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    122. Richter RP, Hock KK, Burkhartsmeyer J, Boehm H, Bingen P, Wang G, Steinmetz NF, Evans DJ, Spatz JP. Membrane-grafted hyaluronan films: a well-defined model system of glycoconjugate cell coats. J Am Chem Soc. 2007 May 02; 129(17):5306-7. PMID: 17408270.
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    123. Steinmetz NF, Calder G, Lomonossoff GP, Evans DJ. Plant viral capsids as nanobuilding blocks: construction of arrays on solid supports. Langmuir. 2006 Nov 21; 22(24):10032-7. PMID: 17106996.
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    124. Steinmetz NF, Lomonossoff GP, Evans DJ. Cowpea mosaic virus for material fabrication: addressable carboxylate groups on a programmable nanoscaffold. Langmuir. 2006 Apr 11; 22(8):3488-90. PMID: 16584217.
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    125. Steinmetz NF, Lomonossoff GP, Evans DJ. Decoration of cowpea mosaic virus with multiple, redox-active, organometallic complexes. Small. 2006 Apr; 2(4):530-3. PMID: 17193081.
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