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    Jan Karlseder

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
    Phone858-453-4100
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Li JS, Miralles Fuste J, Simavorian T, Bartocci C, Tsai J, Karlseder J, Lazzerini Denchi E. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017 Jan 12. PMID: 28082411.
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      2. Rivera T, Haggblom C, Cosconati S, Karlseder J. A balance between elongation and trimming regulates telomere stability in stem cells. Nat Struct Mol Biol. 2016 Dec 05. PMID: 27918544.
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      3. Arnoult N, Karlseder J. Complex interactions between the DNA-damage response and mammalian telomeres. Nat Struct Mol Biol. 2015 Nov 4; 22(11):859-66. PMID: 26581520.
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      4. Hayashi MT, Cesare AJ, Rivera T, Karlseder J. Cell death during crisis is mediated by mitotic telomere deprotection. Nature. 2015 Jun 25; 522(7557):492-6. PMID: 26108857.
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      5. Arnoult N, Karlseder J. ALT Telomeres Borrow from Meiosis to Get Moving. Cell. 2014 Sep 25; 159(1):11-2. PMID: 25259914.
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      6. Karlseder J. Modern genome editing meets telomeres: the many functions of TPP1. Genes Dev. 2014 Sep 1; 28(17):1857-8. PMID: 25184673.
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      7. Lackner DH, Hayashi MT, Cesare AJ, Karlseder J. A genomics approach identifies senescence-specific gene expression regulation. Aging Cell. 2014 Oct; 13(5):946-50. PMID: 24863242.
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      8. O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014 Feb; 21(2):167-74. PMID: 24413054.
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      9. Cesare AJ, Hayashi MT, Crabbe L, Karlseder J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 2013 Jul 25; 51(2):141-55. PMID: 23850488.
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      10. Oganesian L, Karlseder J. 5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events. DNA Repair (Amst). 2013 Mar 1; 12(3):238-45. PMID: 23347616.
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      11. Hayashi MT, Karlseder J. DNA damage associated with mitosis and cytokinesis failure. Oncogene. 2013 Sep 26; 32(39):4593-601. PMID: 23318447.
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      12. Lackner DH, Karlseder J. C. elegans survivors without telomerase. Worm. 2013 Jan 1; 2(1):e21073. PMID: 24058854.
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      13. Crabbe L, Cesare AJ, Kasuboski JM, Fitzpatrick JA, Karlseder J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Rep. 2012 Dec 27; 2(6):1521-9. PMID: 23260663.
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      14. O'Sullivan RJ, Karlseder J. The great unravelling: chromatin as a modulator of the aging process. Trends Biochem Sci. 2012 Nov; 37(11):466-76. PMID: 22959736.
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      15. Cesare AJ, Karlseder J. A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Biol. 2012 Dec; 24(6):731-8. PMID: 22947495.
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      16. Barefield C, Karlseder J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. Nucleic Acids Res. 2012 Aug; 40(15):7358-67. PMID: 22576367.
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      17. Lackner DH, Raices M, Maruyama H, Haggblom C, Karlseder J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. EMBO J. 2012 Apr 18; 31(8):2024-33. PMID: 22425786.
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      18. Hayashi MT, Cesare AJ, Fitzpatrick JA, Lazzerini-Denchi E, Karlseder J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Biol. 2012 Apr; 19(4):387-94. PMID: 22407014.
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      19. Lackner DH, Durocher D, Karlseder J. A siRNA-based screen for genes involved in chromosome end protection. PLoS One. 2011; 6(6):e21407. PMID: 21760879.
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      20. Oganesian L, Karlseder J. Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. Mol Cell. 2011 Apr 22; 42(2):224-36. PMID: 21504833.
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      21. Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 2011 Mar 24; 471(7339):532-6. PMID: 21399625.
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      22. Corpet A, De Koning L, Toedling J, Savignoni A, Berger F, Lemaître C, O'Sullivan RJ, Karlseder J, Barillot E, Asselain B, Sastre-Garau X, Almouzni G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J. 2011 Feb 2; 30(3):480-93. PMID: 21179005.
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      23. Orazio NI, Naeger CM, Karlseder J, Weitzman MD. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J Virol. 2011 Feb; 85(4):1887-92. PMID: 21123383.
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      24. O'Sullivan RJ, Kubicek S, Schreiber SL, Karlseder J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol. 2010 Oct; 17(10):1218-25. PMID: 20890289.
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      25. Crabbe L, Karlseder J. Mammalian Rap1 widens its impact. Nat Cell Biol. 2010 Aug; 12(8):733-5. PMID: 20622867.
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      26. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. PMID: 20351400.
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      27. O'Sullivan RJ, Karlseder J. Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol. 2010 Mar; 11(3):171-81. PMID: 20125188.
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      28. Karlseder J. Chromosome end protection becomes even more complex. Nat Struct Mol Biol. 2009 Dec; 16(12):1205-6. PMID: 19956204.
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      29. Oganesian L, Karlseder J. Telomeric armor: the layers of end protection. J Cell Sci. 2009 Nov 15; 122(Pt 22):4013-25. PMID: 19910493.
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      30. Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 2009 Jul 10; 138(1):90-103. PMID: 19596237.
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      31. Begemann S, Galimi F, Karlseder J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. Aging (Albany NY). 2009 Jan; 1(1):122-130. PMID: 20046894.
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      32. Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell. 2008 Mar 7; 132(5):745-57. PMID: 18329362.
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      33. Verdun RE, Karlseder J. Replication and protection of telomeres. Nature. 2007 Jun 21; 447(7147):924-31. PMID: 17581575.
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      34. Karlseder J, Cooper JP. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. EMBO Rep. 2007 Jun; 8(6):542-6. PMID: 17510654.
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      35. Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2205-10. PMID: 17284601.
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      36. Verdun RE, Karlseder J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell. 2006 Nov 17; 127(4):709-20. PMID: 17110331.
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      37. Karlseder J. Telomeric proteins: clearing the way for the replication fork. Nat Struct Mol Biol. 2006 May; 13(5):386-7. PMID: 16738605.
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      38. Verdun RE, Crabbe L, Haggblom C, Karlseder J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell. 2005 Nov 23; 20(4):551-61. PMID: 16307919.
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      39. Raices M, Maruyama H, Dillin A, Karlseder J. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 2005 Sep; 1(3):e30. PMID: 16151516.
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      40. Crabbe L, Karlseder J. In the end, it's all structure. Curr Mol Med. 2005 Mar; 5(2):135-43. PMID: 15974866.
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      41. Crabbe L, Verdun RE, Haggblom CI, Karlseder J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science. 2004 Dec 10; 306(5703):1951-3. PMID: 15591207.
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      42. Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol. 2004 Aug; 2(8):E240. PMID: 15314656.
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      43. Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol. 2003 Sep; 23(18):6533-41. PMID: 12944479.
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      44. Karlseder J. Telomere repeat binding factors: keeping the ends in check. Cancer Lett. 2003 May 15; 194(2):189-97. PMID: 12757977.
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      45. Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol. 2002 Oct 1; 12(19):1635-44. PMID: 12361565.
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      46. Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science. 2002 Mar 29; 295(5564):2446-9. PMID: 11923537.
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      47. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 1999 Feb 26; 283(5406):1321-5. PMID: 10037601.
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      48. Wolschek MF, Narendja F, Karlseder J, Kubicek CP, Scazzocchio C, Strauss J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. Nucleic Acids Res. 1998 Aug 15; 26(16):3862-4. PMID: 9685506.
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      49. Orel L, Simon MM, Karlseder J, Bhardwaj R, Trautinger F, Schwarz T, Luger TA. alpha-Melanocyte stimulating hormone downregulates differentiation-driven heat shock protein 70 expression in keratinocytes. J Invest Dermatol. 1997 Apr; 108(4):401-5. PMID: 9077466.
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      50. Sliutz G, Karlseder J, Tempfer C, Orel L, Holzer G, Simon MM. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. Br J Cancer. 1996 Jul; 74(2):172-7. PMID: 8688318.
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      51. Sutterluety H, Bartl S, Karlseder J, Wintersberger E, Seiser C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. J Mol Biol. 1996 Jun 14; 259(3):383-92. PMID: 8676376.
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      52. Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996 Apr; 16(4):1659-67. PMID: 8657141.
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      53. Karlseder J, Wissing D, Holzer G, Orel L, Sliutz G, Auer H, Jäättelä M, Simon MM. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. Biochem Biophys Res Commun. 1996 Mar 7; 220(1):153-9. PMID: 8602836.
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      54. Karlseder J, Zeillinger R, Schneeberger C, Czerwenka K, Speiser P, Kubista E, Birnbaum D, Gaudray P, Theillet C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. Genes Chromosomes Cancer. 1994 Jan; 9(1):42-8. PMID: 7507699.
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